Digital Commons Network^™

What's Happening: July 23, 1998, Maine Medical Center

What's Happening

No abstract provided.

2,4-Disulfo Phenyl Butyl Nitrone, Its Salt And Their Use As Pharmaceuticals, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.

What's Happening: July 8, 1998, Maine Medical Center

What's Happening

No abstract provided.

Dentalgram - Vol. 12, No. 07, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• MS degree for dentistry grand students
• Photo gallery
• Kasischke named assistant dean
• Department news
• Inter-American Dental Conference
• Student news

Jefferson Alumni Bulletin – Volume Xlvii, Number 3, July 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 3, July 1998

Drug Development and Clinical Trials, Page 4

Thomas Jefferson university Hospital is Ranked One of the Top 100 in the Country, Page 8

The W.W. Smith Charitable Trust Gives $1.5 Million, Page 9

First GI Text from an Endoscopic Perspective, Page 9

Brucker Lecture on Refocusing of Managed Care, Page 10

Gene Therapy for Canavan’s Disease, Page 11

Decorin May Be a Natural Cancer Fighter in Cells, Page 13

Clue to How a Protein Works to Suppress Tumors, Page 13

Francis Elected to ACP Board of Regents, Page 23

Gap Analysis Of The Vegetation Of The Intermountain Semi-Desert Ecoregion, David M. Stoms, Frank W. Davis, Kenneth L. Driese, Kelly M. Cassidy, Michael P. Murray

Great Basin Naturalist

A conservation gap analysis was conducted for the Intermountain Semi-Desert ecoregion to assess the representation of land-cover types within areas managed primarily for biodiversity objectives. Mapped distributions of plant communities were summarized by land-management status categories. The total amount of land permanently protected in the ecoregion is

Winter Macroinvertebrate Communities In Two Montane Wyoming Streams, Christopher M. Pennuto, Frank Denoyelles Jr., Mark A. Conrad, Frank A. Vertucci, Sharon L. Dewey

Great Basin Naturalist

Macroinvertebrate communities were examined on 4 winter dates over a 4-yr period in 2 high-altitude Rocky Mountain streams to document overwintering assemblages potentially experiencing spring acid pulses. Taxa richness values were comparable to other published lists for alpine and montane stream systems despite the fact that most literature reflected summer collections. Mean benthic density ranged from 1406 to 19,734 organisms/m², and drift rates ranged from 0 to 1740 organisms/100 m³. Benthic collections showed higher taxa richness than drift collections while the Ephemeroptera and Plecoptera occurred in greater proportions in drift than in benthos. The Nemouridae (Plecoptera), …

Update - July 1998, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Christianity and Human Cloning - A Seventh-day Adventist Declaration of Ethical Principles
-- Cloning: Dolly's Mother is Her Sister!?
-- Hello, Dolly! Dolly! Dolly!

Mouse Embryo Development In The Presence Of Capsaicin, Carlos Santiago Villar-Gosalvez

Theses and Dissertations in Biomedical Sciences

Capsaicin is the pungent agent found in hot peppers of the Capsicum genus. It is a potent neurotoxin that stimulates the degranulation and degeneration of C-afferent neurons. Capsaicin is widely used as a food condiment and medicine. Human exposure of capsaicin can exceed levels shown to be neurotoxic in laboratory animals. Additionally, capsaicin can cross the blood/placenta barrier and affect an embryo in utero. In order to assay the potential for toxicity to human embryos, mouse embryos were exposed to capsaicin and the effect of the capsaicin on embryo development was measured. Embryos were co-cultured in Krebs medium with 1% …

Efficacy Of AllowashTm Solution In Solubilization Of Bone Marrow, Alyce Marie Linthurst

Biological Sciences Theses & Dissertations

LifeNet currently cleans allograft bone utilizing Allowash^TM Technology, which encompasses the use of a closed continuous circulation chamber to remove bone marrow by flushing it with Allowash^TM Solution for a prescribed time and temperature after which, it is rinsed with various solutions to remove residual detergent that could be toxic to the recipient. A portion of this process employs Allowash^TM Solution to improve the solubilization and removal of protein and cellular elements in the red bone marrow. This study examines the effectiveness of Allowash^TM Solution in comparison to its component detergents Nonidet P40, Nonoxynol 9 and …

Leukemia Inhibitory Factor (Lif): Murine Preimplantation Embryo Development, Implantation Rates, And Skeletal Development, Michael Hayes Mitchell

Theses and Dissertations in Biomedical Sciences

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine which demonstrates perplexing physiological effects. It has been demonstrated that LIF is essential for implantation in mice. Little is known relating to the manner by which LIF effects pre-implantation and post-implantation development. The objectives of this project were to determine the effects LIF on pre-implantation development, to determine the effects that it may have on implantation rates, successful pregnancy rates, and resorption rates, and to determine the effects that LIF has on the skeletal development of mice. For the embryo transfer experiments, embryos were exposed to test compounds in the transfer medium …

Department Of Radiology-Annual Report-July 1, 1997 To June 30, 1998, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Executive Summary Report, July 1, 1997 to June 30, 1998. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 103 pages.

Implantable Controlled Release Device To Deliver Drugs Directly To An Internal Portion Of The Body, Paul Ashton, Paul A. Pearson

Ophthalmology and Visual Science Faculty Patents

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed.

An Addition To The History Of Psychoanalysis: An Encounter Between Z.V. Togan And S. Freud, Ibpp Editor

International Bulletin of Political Psychology

This article was submitted to IBPP by Dr. H.B. Paksoy concerning the historian Z. V. Togan. It is taken--with appropriate permission--from Z. V. Togan's Hatiralar (Memoirs) as translated by Dr. Paksoy and published in Paksoy's Central Asia Reader: The rediscovery of history. (NY/London: M.E. Sharpe, 1994). (Ed.). ISBN 1-56324-201-X (hardcover)/ISBN 1-56324-202-8 (paperback). Dr. Paksoy's translation was developed to preserve Togan's syntax. What follows is brief introductory material about Dr. Paksoy and Z.V. Togan, then the article entitled A Poem of Mother's and Freud, and finally a brief commentary by IBPP.

Expression Of Constitutively Active Raf-1 In The Mitochondria Restores Antiapoptotic And Leukemogenic Potential Of A Transformation-Deficient Bcr/Abl Mutant., P Salomoni, M A Wasik, R F Riedel, K Reiss, J K Choi, T Skorski, B Calabretta

Department of Microbiology and Immunology Faculty Papers

The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176-426 in the BCR domain (p185DeltaBCR) failed to protect interleukin 3-deprived 32Dcl3 myeloid precursor cells from apoptosis, although it possessed tyrosine kinase activity and was capable of activating the Ras-Raf-MAP kinase pathway. Compared to p185 wild-type transfectants, p185DeltaBCR-transfected cells showed markedly reduced levels of Bcl-2 and expressed the hypophosphorylated, proapoptotic form of BAD. Bcl-2 expression in the mitochondrial fraction of p185DeltaBCR cells was also markedly diminished and mitochondrial RAF was undetectable. In p185DeltaBCR …

Ethics And Uncertainty: In Vitro Fertilization And Risks To Women's Health, Inmaculada De Melo-Martin

RISK: Health, Safety & Environment (1990-2002)

Dr. de Melo-Martin examines the risks, uncertainties and public policies surrounding in vitro fertilization and women's health issues.

Fmri Of Monkey Visual Cortex, Lisa Stefanacci, Paul Reber, Jennifer Costanza, Eric Wong, Richard Buxton, Stuart Zola, Larry R. Squire, Thomas D. Albright

Neurology Collection

While functional magnetic resonance imaging (fMRI) is now used widely for demonstrating neural activity-related signals associated with perceptual, motor, and cognitive processes in humans, to date this technique has not been developed for use with nonhuman primates. fMRI in monkeys offers a potentially valuable experimental approach for investigating brain function, which will complement and aid existing techniques such as electrophysiology and the behavioral analysis of the effects of brain lesions. There are, however, a number of significant technical challenges involved in using fMRI with monkeys. Here, we describe the procedures by which we have overcome these challenges to …

Developmental Expression Of Rat Target Of The Antiproliferative Antibody (Rtapa) Protein In The Brain, Clyde Dale Sullivan

Theses and Dissertations (ETD)

The present study defines the expression pattern of rTAPA (CD81) in the developing rat brain. rTAPA is a member of the tetramembrane spanning family of proteins, and like other members of this family, appears to be associated with the stabilization of cellular contacts. On immunoblots of the brain, rTAPA is present in higher levels than any other tissue examined: muscle, tendon, peripheral nerve, cartilage, liver, kidney, skin, and testicle. Immunohistochemical methods were used to define the distribution of rTAPA in the brain. This protein is expressed by ependyma, choroid plexus, astrocytes, and oligodendrocytes, and rTAPA is dramatically upregulated at the …

Disruption Of The Discriminative Stimulus Effects Of (+)-3, 4-Methylenedioxymethamphetamine (Mdma) By (± )-Mdma Neurotoxicity: Protection By Fluoxetine, Thomas B. Virden Iii

Dissertations

It is well established that repeated, high doses of 3, 4-methylenedioxymethamphetamine (MDMA) result in the long-term depletion of serotonin levels and destruction of serotonergic terminals in various locations in the brains of a variety of species. Further, it is also well known that concomitant injections of the serotonin reuptake inhibitor, fluoxetine, prevents this deterioration. It has recently been noted that such MDMA neurotoxicity disrupts stimulus control in rats trained to discriminate MDMA from saline in a drug discrimination procedure (Schechter, 1991a).

In order to extend Schechter's findings to the optical isomers of MDMA and to explore the potential of fluoxetine …

The Relation Of Weight Loss And Improved Fitness To Survival In Healthy Males, Joanna Lynn Bokovoy

Loma Linda University Electronic Theses, Dissertations & Projects

Obesity is a critical public health problem because of its prevalence, medical and psychosocial effects, and resistance to intervention. Weight loss in overweight individuals has been encouraged by the United States Public Health Service and by the medical community as a means for improving health. However, recent studies have suggested either positive or negative effects of weight loss on survival. It is possible that physical fitness may have a confounding effect, or be an effect modifier on survival in weight loss studies.

This study used Cox Regression analysis to address the separate and combined association of weight loss and improved …

Causation In Occupational Disease: Balancing Epidemiology, Law And Manufacturer Conduct, Richard M. Lynch, Mary S. Henifin

RISK: Health, Safety & Environment (1990-2002)

Drs. Lynch & Henefin examine evolution of disease causation theory and its impact on public health, as well as how these relate to the courtroom admissibility of expert opinion evidence.

Effect Of Postmenopausal Hormone Replacement Therapy On Heart Rate Variability, Diane Todd Pace

Theses and Dissertations (ETD)

Minimal research has addressed effects of postmenopausal hormone replacement therapy (HRT) on heart rate variability (HRV), a measure of cardiovascular autonomic balance and a predictor of cardiac morbidity/mortality. Using an exploratory, pre-test/post-test design to describe HRV in postmenopausal women (PMW) before/after six weeks of HRT, twenty-four Black (n=15) and White (n=9) women, (mean age=55±4 years), were recruited from two primary care clinics (n=20) and one church population (n=4) in a large urban midsouth community. Cardiovascular risk factors for the sample included chronic illnesses of DM (n=8), HRT (n=11), both DM and HRT (n=4), smoking (n=9), non-exercise (n=11), and obesity quantified …

Regeneration In Periodontal Defects With Rhbmp-2 : A Dosage Study, Paola Guglielmoni

Loma Linda University Electronic Theses, Dissertations & Projects

Bone morphogenetic proteins (BMPs) have been shown to induce bone formation in ectopic and orthotopic sites. This inductive capability has led to their evaluation as possible adjuncts in periodontal reconstructive therapy. Indeed, studies have reported periodontal regeneration following surgical implantation of recombinant human BMP-2. This study evaluated regeneration of alveolar bone and cementum following periodontal reconstructive surgery including implantation of a construct consisting of sterile lyophilized rhBMP-2 in buffer adsorbed onto an absorbable collagen sponge. Critical size mandibular supra-alveolar periodontal defects were surgically created, and an incomplete block design was used to evaluate the regenerative potential of rhBMP-2 at 0.05, …

A Model Using Radiation And Pws4-Htnf-Α Gene Therapy For Treatment Of Glioblastomas, Angelo G. Baher

Loma Linda University Electronic Theses, Dissertations & Projects

The efficacy of radiotherapy for cancer is limited by the dose that can be safely delivered to the tumor without causing debilitating side effects. In addition, successful treatment of highly malignant tumors such as glioblastomas is likely to require adjunctive therapies to enhance tumor response to radiation. Previous studies have shown immunomodulation and a synergestic reduction in tumor volume of malignant tumors when tumor necrosis factor-α (TNF-α) protein is administered prior to radiation. The major goal of the present investigation was to evaluate the efficacy of pWS4-human TNF-α (pWS4-hTNF-α), a new plasmid construct that expresses human TNF-α protein, together with …

The Effects Of Reminiscence Therapy On The Elderly Client's Satisfaction With Nursing Care, Nancy Strong

Masters Theses

This study tested if reminiscence therapy would improve client satisfaction with nursing care. An experimental post test only design was used on 39 clients in a moderate sized home care agency in the Midwest. Ages ranged from 65 to 98. A single, one-on-one reminiscence session was done with 22 subjects in their homes after a routine nursing visit. The control group subjects did not receive the reminiscence intervention. The groups were homogeneous except for the number of hospitalizations experienced in the past year. The control group had a significantly higher number.

The Forbes Patient Satisfaction Questionnaire, modified for the home …

Wild Primate Populations In Emerging Infectious Disease Research: The Missing Link?, Nathan D. Wolfe, Ananias A. Escalante, William B. Karesh, Annelisa Kilbourn, Andrew Spielman, Altaf A. Lal

Harold W. Manter Laboratory of Parasitology: Library Materials

Wild primate populations, an unexplored source of information regarding emerging infectious disease, may hold valuable clues to the origins and evolution of some important pathogens. Primates can act as reservoirs for human pathogens. As members of biologically diverse habitats, they serve as sentinels for surveillance of emerging pathogens and provide models for basic research on natural transmission dynamics. Since emerging infectious diseases also pose serious threats to endangered and threatened primate species, studies of these diseases in primate populations can benefit conservation efforts and may provide the missing link between laboratory studies and the well-recognized needs of early disease detection, …

Rescuing Rover: A First Aid And Disaster Guide For Dog Owners, Sebastian E. Heath

Purdue University Press Books

Whether you're hiking with your canine friend in a remote area or work with a dog on a search-and-rescue team or police force, you need to be prepared for emergencies when veterinary service is not available. Rescuing Rover: A First Aid and Disaster Guide for Dog Owners provides dog owners, handlers, and emergency physicians with an understandable guide for safe treatment until the dog can be transported to a veterinarian. Although a number of books describe some techniques for the emergency care of dogs, there is no single illustrated summary that is as practical. With its concise, easy-to-read instructions, detailed …

A Field Evaluation Of Ivomec-F For The Treatment Of Naturally Acquired Fasciola Gigantica And Other Gastrointestinal Nematode Infections In Cattle And Buffaloes, Tasanee Chompoochan, Suwannee Nithiuthai, Piyanoot Prasittirat

The Thai Journal of Veterinary Medicine

The efficacy of Ivomec-F was evaluated in 60 cattle and 14 buffaloes that had a naturally acquired infection of Fasciola gigantica. Some animals were also concurrently infected with gastrointestinal nematodes. The animals were divided equally into treatment and control groups. Treatment group 1 which consisted of 30 cattle, were administered a single subcutaneous dose of Ivomec-F (1% ivermectin /10% clorsulon) 1 ml/ 50 kg body weight. Control group 2 which consisted of 30 untreated cattle, were given the same volume of physiological saline. Groups 3 and 4 (7 treated and 7 control buffaloes) were treated in a similar manner as …

An Evaluation Of Root End Filling Materials Using Endotoxin, Hong-Ming Tang

Loma Linda University Electronic Theses, Dissertations & Projects

Mineral Trioxide Aggregates (MTA) was recently developed at Loma Linda University. It has been shown to possess good sealing ability when tested with dye, bacteria, and a fluid filtration technique.

Endotoxin is a component of the cell wall of Gram negative bacteria. It has been proposed that it may play a role in the pathogenesis of periradicular lesions. Previous studies have demonstrated that MTA can prevent the leakage of bacteria. However, the bacterial products were not tested during these studies.

This study used endotoxin to compare the sealing ability of SuperEBA, IRM, amalgam, and MTA.

The results showed that MTA …

Analysis Of Serotonin And Postural Instability In Parkinson’S Disease, Sandra Kuniyoshi

Loma Linda University Electronic Theses, Dissertations & Projects

Postural instability is one of the most debilitating symptoms of Parkinson’s disease and the best clinical prognostic indicator of progressive disease. Significant differences in neuropathology, neurochemistry, response to L-dopa therapy and stereotactic surgery as well as prognosis have been identified in subtypes when patients with predominant postural instability and gait difficulty (PIGD)/Type B were differentiated from those with predominant symptoms of tremor and rigidity/Type A. Postural instability is resistant to the therapeutic effects of L-dopa, despite its continued efficacy on other Parkinson’s symptomatology, implicating the nondopaminergic mechanism of postural instability in Parkinson’s disease. Patients with significant postural instability and gait …