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Pathophysiology Of Male Hypogonadism Associated With Endogenous Hyperestrogenism — Evidence For Dual Defects In The Gonadal Axis, Johannes D. Veldhuis, James R. Sower, Alan D. Rogol, Frederick A. Klein, Norman Miller, Maria L. Dufau

Surgery Publications

FEMINIZING tumors of the adrenal cortex are associated with symptoms that presumably reflect the combined effects of estrogen excess and androgen deficiency — gynecomastia, diminished libido, attenuated potency, and testicular and prostatic atrophy.1 2 3 4 5 Although such tumors are extremely rare, they provide a unique opportunity to appraise the nature of endogenous estrogen action on the gonadal axis in men. In principle, the pathophysiologic effects of estrogen hypersecretion could be expressed at the level of either the Leydig cell or the hypothalamic–pituitary axis (or both), with consequent suppression of androgen production. In the present studies, we investigated …

Computer Model Of Anterior Communicating Artery Aneurysm And Vasospasm, G. Austin

The Dr. George M. Austin Neurology Research Collection

Computer Model of Anterior Communicating Artery Aneurysm and Vasospasm. G. Austin and R. Gaskell. Typed manuscript, 3 p. plus 4 pages of handwritten notes. See additional file. Poster boards used in the presentation are also held in the Department of Archives and Special Collections at Loma Linda University. Presentation date unknown.

Anterior Communicating Artery Aneurysm And Vasospasm - A Computer Model, G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model. G. Austin, R. Gaskell. Poster presentation. Annual Meeting of American Association of Neurological Surgeons, Atlanta, CA. 1985. 8 pg

Anterior Communicating Artery Aneurysm And Vasospasm – A Computer Model., G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model. G. Austin, R. Gaskell. Poster presentation. Annual Meeting of American Association of Neurological Surgeons, Atlanta, CA. 1985. 8 pg.

Oncolog, Volume 30, Number 01, January-March 1985, Jordan U. Gutterman Md, Edwin C. Murphy, Jr. Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Investigators Explore Role of Oncogenes in Normal Growth and Carcinogenesis
• Lung Cancer Surpasses Breast Cancer as Mortality Risk to Texas Women
• New NCI Data Base Offers Physicians Up-to-Date Cancer Treatment Information

Oncolog, Volume 30, Number 03, July-September 1985, Fernando F. Cabanillas Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Natural Killer Cells: Research Shows They Are Early Destroyers of Malignancy
• Better Classification and New Drug Regimens Have Advanced Treatment for Lymphoid Cancer
• Rural Science Park is Laboratory for Basic Work on Carcinogenesis
• New Book: Candidiasis

Oncolog, Volume 30, Number 04, October-December 1985, Oncolog Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Endocrine Therapy for Prostatic Cancer Can Replace Orchiectomy and Estrogens

Oncolog, Volume 30, Number 02, April-June 1985, Karel A. Dicke Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Ultraviolet Radiation Perturbs Immune System, Makes Mice More Susceptible to Tumor Growth
• Bone Marrow Transplantation Makes High-Dose Cytoreductive Regimens, Remissions Possible
• Psychological and Social Cures Next for Children Who Recover from Cancer

The Immunology Of Transplantation, J. R. Serie

Journal of the Minnesota Academy of Science

A number of life-threatening diseases, such as kidney failure, diabetes, and certain kinds of coronary heart disease, can be cured by organ transplantation. However, despite decades of research, graft rejection remains a very real threat to the organ transplant recipient. In attempting to develop methods that interfere with the graft rejection process, scientists have uncovered a remarkably complex system of cellular interactions that allows the total destruction of a transplanted organ while leaving the recipient's own organs untouched. This ability to distinguish self from non-self is achieved through intercellular communication involving cell-to-cell contact and the release of a number of …

Sulfite Residues In Maraschino Cherries, Julie A. Nordlee, Laura B. Martin, Steve L. Taylor

Department of Food Science and Technology: Faculty Publications

A survey of 53 samples of maraschino cherries from 14 different processors revealed that total sulfite residues averaged 52.3 ± 44.7 ppm. However, 58.5% of the samples had less than 40 ppm total SO₂, while only 7.6% had greater than 120 ppm total SO₂ indicating that the distribution was skewed in the direction of lower residue levels. Free sulfite residues in the 53 samples were considerably lower, averaging 14.2 ± 7.1 ppm. With free SO₂ levels, 35.8% of the samples had less than 10 ppm free SO₂, while only 5.7% had greater than 30 …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1929-1985) T1701-T1800, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1701. TRANSLATION FROM RUSSIAN, OVEZMUKHAMMEDOV, A. and SAF'YANOVA, V. M. (1983), Occurrence of amastigotes of Leishmania gymnodactyli in the peripheral blood of Gymnodactylus caspius and Agama caucasica. Parazitologiya, Leningrad. 17(3):185-188.

T1702. TRANSLATION FROM RUSSIAN. YASTREBOV, V. K. and YURLOV, K. T. (1978). Possible arbovirus dissemination in western Siberia in connection with data on migrations and overwinterings of west Siberian birds. Dokl. Simp. Transkont. Svyazi Pereletn. Ptits Rol' v Rasp. Arbovirus. (Novosibirsk, July-August, 1976), pp. 167-172.

T1703. TRANSLATION FROM GERMAN. MOSKVIN, I. A. (1929). On the role of the tick Ornithodoros papillipes Bir. (Ixodoidea) in transmitting relapsing fever in Turkestan. Z. …

The Effects Of Needle Play On Pre-School Children's Anxiety Concerning Injections, Michelle Anne Belyea

Theses and Dissertations

The purpose of this study was to determine the effects of needle play in reducing pre-school children's anxiety concerning injections. The Pre-school Observational Scale of Anxiety was used to measure the degree of anxiety experienced by the children. The hypothesis stated that there would be a significant decrease in anxiety of pre-school children who participated in needle play as compared with the anxiety scores of pre-school children who did not participate in needle play.The sample consisted of 20 pre-school children who were receiving routine health care and injections for immunizations or PPDs (purified protein derivative) at a county health department …

Low Toxicity Radiation Sensitizer, Barton L. Bergquist, James C. Chang

Patents (University of Northern Iowa)

Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.

Correspondence, Loring M. Thompson To William Bergen, D.O., 1984 December 22, Loring M. Thompson

William F. Bergen, D.O. Collection

Letter from Loring M. Thompson to William Bergen, D.O. recording his memories from the creation of the University of New England College of Osteopathic Medicine.

Correspondence, Robert R. Brown, D.O. To William Bergen, D.O., 1984 December 21, Robert Russell Brown D.O.

William F. Bergen, D.O. Collection

Letter form Robert Brown, D.O. to William Bergen, D.O. including a "History of Osteopathic Education in New England."

Correspondence, Edward P. Crowell, D.O. To William Bergen, D.O., 1984 December 11, Edward P. Crowell D.O.

William F. Bergen, D.O. Collection

Letter from Edward P. Crowell, D.O. to William Bergen, D.O. relating his experiences in the founding of the University of New England College of Osteopathic Medicine.

Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner

Henry Ford Hospital Medical Journal

A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large …

The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson

Henry Ford Hospital Medical Journal

No abstract provided.

Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander

Henry Ford Hospital Medical Journal

We evaluated the effects of screening for multiple endocrine neoplasia type 2A (MEN-2A) in 12 families. Genealogical studies going back to 1730 show a common ancestry for seven Swedish families and one American family. The total number of patients included 105 individuals, 68 of whom were diagnosed by our screening program. Our screening methods for medullary carcinoma of the thyroid (MTC) had an optimal sensitivity and specificity. The frequency of gene carriers detected in MEN-2A families was 55%. Screening will lead to early diagnosis and early therapy, which in turn, will significantly decrease morbidity, incidence of surgical complications, and mortality …

Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten

Henry Ford Hospital Medical Journal

No abstract provided.

Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson

Henry Ford Hospital Medical Journal

In 19 patients from nine MEN-2A families, high-resolution C-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.

Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill

Henry Ford Hospital Medical Journal

Progress in understanding the single gene, cytogenetic, and multifactorial traits that predispose to human cancer suggests possible new directions for research in the multiple endocrine neoplasia (MEN) syndromes. Among the other 200 or so monogenic disorders associated with human neoplasia, advances have come from further delineation of syndromes by various clinical specialists, the recognition of subtypes of syndromes previously thought to be homogeneous, the search for in vitro manifestations of the mutant gene in fibroblasts, and the establishment of cell, tissue and patient registries and of voluntary lay organizations to serve as advocates for the disease. With regard to cytogenetics, …

Book Review: Medical Meanings, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple

Henry Ford Hospital Medical Journal

No abstract provided.

The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin

Henry Ford Hospital Medical Journal

No abstract provided.

Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder

Henry Ford Hospital Medical Journal

A collaborative group for the study of multiple endocrine neoplasia type 2 (MEN-2) syndromes comprised of clinicians and laboratory scientists has been set up in the United Kingdom. Its aims are 1) to provide a basis for collaborative work on MEN-2; 2) to establish a register of patients; 3) and specifically to conduct studies aimed at defining the best policy for screening the families of apparently sporadic patients, to establish radioimmunoassays for family screening, and to identify large kindreds for genetic linkage studies using DNA polymorphisms.

Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen

Henry Ford Hospital Medical Journal

Screening of first-degree relatives of patients with medullary thyroid cancer (MTC) gave normal values of pentagastrin-stimulated serum calcitonin and 24-hour urinary catecholamine levels in the relatives of 18 of 22 patients. This result is considered to be valid evidence for sporadic MTC. Absence of C-cell hyperplasia maybe another indication of sporadic MTC. Four hereditary MTCs were represented by one fully expressed MEN-2B patient without affected relatives, one fully expressed MEN-2A case in one family, and two first cousins with MTC as the only MEN-2A lesion in another family. Fourteen relatives of the MEN-2A patients had elevated serum calcitonin levels, and …

Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara

Henry Ford Hospital Medical Journal

Through nationwide surveys, we collected and analyzed 242 patients of medullary thyroid carcinoma (MTC). Included were 40 patients with multiple endocrine neoplasia type 2A (MEN-2A), six patients with MEN-2B, and 36 patients with only MTC having a positive family history (82 total patients in the hereditary group). Ten-year survival rates were 81.5% for all cases, and 97.5% and 76.1% for the hereditary and the sporadic group, respectively. Epinephrine/norepinephrine ratio in the urine was found to be a good indicator of the adrenomedullary hyperfunction in patients with hereditary MTC. At least one patient in each family with hereditary MTC had overt …