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Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1978), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1978 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• We've Come a Long Way, Baby!
• A Working Formula for Learning
• Meet the Chairman of the Board
• The Class of 1982
• Open House
• Faculty Notes
• News from the College
• News from the Hospital and Health Care Centers
• Rugby
• Alumni News Briefs
• From the Alumni Office
• In Memoriam

Vital Signs, October, 1978, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

A Comparison Of Kidney Preservation Methods By Oxidative Phosphorylation Studies, Devprakash Samuel, Stanley G. Dienst

Henry Ford Hospital Medical Journal

An oxygen consumption assay using adenosine diphosphonucleotide (ADP) was performed on canine kidneys to measure the efficiency of oxidative phosphorylation. The purpose of the assay was to establish a respiratory control index (RCI) that could be used to evaluate kidneys preserved by different methods. Of the four methods tested, perfusion yielded the best results after 24-hour preservation. Additionally, four pairs of human cadaver kidneys were evaluated with the same assay. Some correlation existed between the RCI values of the nontransplanted kidney in each pair and the clinical viability of its transplanted mate.

Effect Of Donor Pretreatment On The Graft Survival Of Human Cadaver Kidneys, Stanley G. Dienst, Krishna D. Valjee, Luis H. Toledo-Pereyra

Henry Ford Hospital Medical Journal

The effect of donor pretreatment on perfused cadaver kidney allografts was evaluated in 40 recipients at Henry Ford Hospital over a two-year period. Ofthe 40,23 received kidneys from donors pretreated with 40 mg/K each of cyclophosphamide and methylprednisolone during the first year of the study and up to 70 mg/K during the second year. Our results indicated that donor pretreatment for five to eight hours did not consistently improve survival rates in pretreated perfused cadaver kidneys following transplantation. The use of cyclophosphamide for donor pretreatment does not prevent the use of continuous perfusion to preserve human kidneys. Dosages up to …

Radionuclide Evaluation Of Renal Transplant Patients, Daniel S. Marks

Henry Ford Hospital Medical Journal

Radionuclide examinations provide considerable information in evaluating patients who have received renal transplants. In the uncomplicated case, baseline data should be obtained so that subsequent changes in renal function can be better documented. In the complicated case, rapid delineation of the problem may result in more effective therapy. Serial examinations with several radiopharmaceuticals represent the best nuclear approach to the transplant patient. This paper describes the application and performance of these tests as currently performed at Henry Ford Hospital.

Treatment Of Uremic Diabetic Patients: Hemodialysis Or Transplantation?, Godofredo Santiago, Cosme Cruz, Francis Dumler, Pedro Cortes, Stanley Dienst, Sandra Parnell, Maxine Uniewski, Nathan W. Levin

Henry Ford Hospital Medical Journal

Eighty-one patients with chronic renal failure associated with or secondary to diabetic nephropathy were treated with dialysis and/or transplant. Twenty-five had juvenile diabetes and 56 had adult onset diabetes. Juvenile diabetics did poorly on hemodialysis with 13 patients having a 19% four-year survival rate, whereas those who had cadaveric transplantation did well with a four-year patient and graft survival rate of 56% in nine patients. The three juvenile diabetics who received related kidney grafts are presently alive with good function. Patients with adult onset diabetes did well on hemodialysis with a four-year survival rate of 63% in 45 patients. In …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Common Sense And Surgical Research, Melvin A. Block

Henry Ford Hospital Medical Journal

No abstract provided.

Effect Of Acute Posttransplant Renal Failure On The Survival Of Perfused Cadaver Kidneys, Krishna D. Valjee, Luis H. Toledo-Pereyra, Stanley G. Dienst, Heung K. Oh, Daniel S. Marks, Pedro Cortes, Cosme Cruz, Godofredo Santiago, Nathan W. Levin

Henry Ford Hospital Medical Journal

Between 7973 and 7977 we encountered 22 cases of acute renal failure after transplantation in 70 patients who received perfused cadaver kidneys. Nearly two-thirds of 76 nonfunctioning grafts were lost due to subsequent superimposed rejection, often undetected and, hence, untreated. Thirty-one percent of the 76 recovered function. The recovery rate, we believe, can be improved by earlier diagnosis and treatment of rejection and by avoiding invasive diagnostic procedures in the early postoperative period. If the oliguric period extends beyond two weeks, a closed percutaneous renal biopsy is justified. The diagnosis of rejection and/or other abnormality as well as subsequent treatment …

Histocompatibility Testing In Renal Transplantation, Hajime Hayashi, Jay B. Hunter

Henry Ford Hospital Medical Journal

The effect of HLA matching and other aspects of histocompatibility on renal graft survival were analyzed in 144 patients who received renal transplants at Henry Ford Hospital during the past ten years. Living related transplants with one haplotype match or better demonstrated a higher graft survival rate (at least 88%) at one year than the better matched cadaveric transplant. In cadaveric transplants, the group with fewer than two mismatched antigens appeared to have a higher graft survival rate than those with more than two. The patient population was not large enough to determine the effect of preformed antibodies, ABO grouping, …

Urological Complications In Renal Transplantation, Riad N. Farah, Richard Klugo, Thomas Mertz, Joseph C. Cerny

Henry Ford Hospital Medical Journal

There were 116 renal transplants performed on 108 patients over a five-year period at Henry Ford Hospital with three major urological complications. The rate of 2.6% compares favorably with that reported in other series. Careful preoperative urological evaluation together with technically precise ureteroneocystostomy are factors that minimize the incidence of urological complications.

Intravenous Methylprednisolone For Kidney Transplantation, Krishna D. Valjee, Luis H. Toledo-Pereyra

Henry Ford Hospital Medical Journal

The effect of different dosage levels (0-100 mg/k/day x 3)of intravenous methylprednisolone was tested in canine kidney autografts undergoing immediate contralateral nephrectomy. Intravenous methylprednisolone was safely administered in doses up to 40 mg/k/day for three days after kidney transplantation. Higher doses ( 40 mg/k/day x 3) were functionally and structurally harmful to canine kidney autografts.

Prolonging Kidney Graft Survival With Concanavalin A: Effects Of Temperature, Perfusate Composition, Ph, And Different Manufacturing Lots, Luis H. Toledo-Pereyra, Richard L. Simmons

Henry Ford Hospital Medical Journal

This study analyzes the effect of temperature, perfusate composition, pH, and variable manufacturing lots in prolonging kidney allograft survival with Concanavalin A (Con A). Cold temperature (4°C), crystalloid composition of the perfusates, and neutral or mildly alkaline pH were important factors in the effect of Con A on prolonging allograft survival. Also, different lots of Con A from the same manufacturer produced variable results in prolonging survival. Thus, multiple factors should be considered if Con A is to be used to prolong kidney allograft survival.

Reevaluation Of A New Colloid Hyperosmolar Solution For Hypothermic Storage Of Ischemic Canine Kidneys, Manuel Chee, Luis H. Toledo-Pereyra, Richard M. Condie

Henry Ford Hospital Medical Journal

This paper describes the results of experiments designed to test the effectiveness of a new colloid hyperosmolar solution (Toledo-Pereyra) for renal hypothermic storage. Three experimental conditions were employed: 60 minutes of warm ischemia (37 C), 24 hours of hypothermic storage, and a combination of warm ischemia and hypothermic storage. Canine kidneys tolerated either one of the first two procedures when flushed with the colloid hyperosmolar solution before storage or transplantation. If warm ischemia was applied before 24 hours of hypothermic storage, four of six dogs survived more than 20 days after transplantation, while the other two died of uremia. Thus, …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Vital Signs, September, 1978, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

New Mexico Location List Of Alumni And Former Housestaff, Unm Medical School Alumni Office

University of New Mexico School of Medicine Location Report

This report relates the locations of UNM School of Medicine Alumni and Housestaff as well as other information about School of Medicine graduates.

Newsletter, Volume 23, Number 05, September - October 1978, Naguib A. Samaan Md, Phd, M. Khalil Ali Md, Phd, Charles K. Tashima Md

Newsletter: A Report to Physicians of Texas Archives

• Dr LeMaistre Assumes Presidency
• Hypopituitarism After Irradiation, Naguib A. Samaan, MD, PhD
• Dear Texas Physician, Dr. Charles A LeMaistre, MD
• To Refer a Patient
• CIS Adds Bilingual Program
• Nurses Receive B&PW Funds
• Respiratory Failure in Cancer Patients, M. Khalil Ali, MD, PhD
• In Memoriam: Olga Keith Wiess
• Cancer Rehabilitation and the Medical Oncologist, Charles K. Tashima, MD

Nutritional Aspects In The Care Of The Child With Cleft Lip And Palate, Mary E. Keitel

Henry Ford Hospital Medical Journal

Proper nutrition is essential in the care of the infant with cleft lip or palate, as these infants are often plagued with feeding difficulties from birth. This paper reviews recent literature on the many feeding practices in use today and discusses the current trend toward a multidisciplinary approach to treatment for the cleft lip/palate child. It also presents a brief review of experimental animal studies which have implicated nutritional deficiences in the causation of cleft lip/palate.

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1978), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1978 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Commencement
• Commencement Speaker
• Some 1978 Graduates
• Commencement Dinner
• Awards
• Excerpts from Commencement Speech
• Annual Fund Report
• Promotions
• New Appointments
• From the Alumni Office
• News from the College
• News from the Hospital and Health Care Centers
• Alumni News Briefs
• Board of Trustees News Briefs
• Class of 1978
• In Memoriam

Vital Signs, July, 1978, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Newsletter, Volume 23, Number 04, July - August 1978, Steven J. Culbert Md, Chiu-Nan Lai Phd, Joseph Sinkovics Md, Carl Plager Md

Newsletter: A Report to Physicians of Texas Archives

• Dr Clark Retires
• Nuclear Fallout Effects in the Marshall Islands, Steven J. Culbert, MD
• Newsletter Mailing List Conversion
• Metabolic Activation of Carcinogens Inhibited by Wheat Extracts, Chiu-Nan Lai, PhD
• Upton Speaks at Science Park Dedication
• Solid Tumor Service Activities
• Distinguished Service Awards
• Chemotherapy-Induced Stomatitis and Periodontal Disease

Length Of Perfusion Time In Cadaver Kidney Transplantation, Krishna D. Valjee, Luis H. Toledo-Pereyra, Stanley G. Dienst, Cosme Cruz, Pedro Cortes, Godofredo Santiago, Nathan W. Levin, Riad Farah, Joseph C. Cerny

Henry Ford Hospital Medical Journal

The results of transplantation survival for 70 consecutive cadaver kidneys preserved under hypothermic pulsatile perfusion at Henry Ford Hospital are reviewed. Pulsatile perfusion for up to 30 hours did not adversely alter the survival rate following transplantation. Thus, kidneys perfused for prolonged periods of time (> 20 hours) can be used for transplantation, if the basic rules for organ retrieval and preservation have been followed. Hypothermic pulsatile perfusion of cadaver kidneys has been demonstrated to be an adequate system for ex-vivo preservation for transplantation.

Intracardiac Phonocardiography In Subaortic Stenosis, Paul D. Stein, Hani N. Sabbah, Daniel T. Anbe, Fareed Khaja, Gordon M. Folger Jr.

Henry Ford Hospital Medical Journal

The purpose of this study is to explore the value of intracardiac sound recordings for the verification of subaortic stenosis. Intracardiac sound was measured in ten patients with subaortic obstructions. Seven had idiopathic hypertrophic subaortic stenosis, two had a subvalvular membrane, and one had a subvalvular tunnel. In each patient, a systolic murmur was recorded within the left ventricle distal to the obstruction. The murmur was of lower amplitude distal to the aortic valve, and it was of even lower amplitude or absent proximal to the obstruction. In the presence of entrapment, no intraventricular murmur occurred although an apparent subvalvular …

Clinical Notes: Bacteremia Associated With Colonoscopy, A. Suarez, B. Schuman, E. Quinn, T. Neblett

Henry Ford Hospital Medical Journal

Twenty-eight patients had a total of 168 blood cultures before and at regular intervals during colonoscopy. No bacteremia was found. Based on our results and other reports, we recommend antibiotic prophylaxis during colonoscopy only for those patients with prosthetic heart valves and for those with valvular heart disease who also have advanced liver disease.

Emergency Transvenous Cardiac Pacing, Carl E. Bartecchi

Henry Ford Hospital Medical Journal

A single pacemaker electrode catheter placement procedure, using the subclavian route and a semi-floating pacemaker catheter, was utilized in 120 consecutive patients who required emergency cardiac pacing. Stable pacing was achieved in a high percentage with few complications.

Noninvasive Techniques In The Evaluation Of Arterial Disease, J. Dennis Baker

Henry Ford Hospital Medical Journal

This paper reviews noninvasive technology currently being applied in clinical peripheral vascular laboratories for the evaluation of obstructive arterial disease in the lower extremities and in the cerebral circulation. Lower extremity, arterial insufficiency can be assessed by pressures measured with a Doppler flowmeter or by oscillometric tracings obtained with a Pulse Volume Recorder. Carotid artery stenosis is studied by: 1) ocular pneumoplethysmography, which indirectly measures ophthalmic artery pressure; 2) oculoplethysmography, which compares pulse arrival time at the two eyes; and 3) the Doppler ophthalmic test, which detects the flow pattern in the ophthalmic artery. The main uses of the tests …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Distant Metastasis Of Locally Controlled Supraglottic Laryngeal Carcinoma: A Report Of Two Cases, Charles N. Ford, William W. Finch, Roger W. Kwong

Henry Ford Hospital Medical Journal

Two cases of supraglottic laryngeal carcinoma are presented in which distant metastasis occurred after adequate local control had been established. The metastasizing tendency of this lesion is discussed, and the efficacy of combined therapeutic approaches in treating these cases is questioned. Submitted

What's New In Crohn's Disease Treatment, Francis J. Owens

Henry Ford Hospital Medical Journal

Progress in the management of Crohn's disease is limited by our inability to compare different patients. Two methods of evaluating the severity of disease have recently been published. Of these, the National Cooperative Crohn's Disease Study (NCCDS) method has been utilized in a study reported on at several national meetings but still in progress. Antibiotics in intensive prolonged dosage, e.g. ampicillin, 500 mg qid for several months, have recently been reported to benefit greater than 90% of patients not responding to conventional therapy. Metronidazole and dapsone continue to be mentioned in letters to journals. Sulfasalazine has been found useful in …