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Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1993), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1993 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: Hospitals’ Sale Signals New Beginnings
• DO/MBA Program: Higher Degrees of Health Care
• Commencement ‘93
• A Glimpse of the Cass of 1993
• Bulletin Board
• Class Acts
• Readership Survey
• Coming Events

Suppressive Effects Of Transforming Factor-Β And Interleukin-10 On The Cytolytic Activity Of Murine Macrophages And Reversal By Cytokines, Chin-Hung Lin

Loma Linda University Electronic Theses, Dissertations & Projects

In this study, the suppressive effects of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and peptone-activated macrophages was compared. The cytolytic activity for tumor cells of these effector cells was measured by percent lysis of ³H-thymidine labeled Herpes simplex virus type 2-transformed tumor cells (H238). After 18-24 hours of incubation with TGF-β or IL-10, the cytolytic activity of macro-medium alone. The immunosuppressive effect of TGF-β or IL-10 on non-activated macrophages was …

Regulation Of Human Lung Fibroblast Alpha 1(I) Procollagen Gene Expression By Tumor Necrosis Factor Alpha, Interleukin-1 Beta, And Prostaglandin E2., Arturo Diaz, Elena Munoz, Rosemary Johnston, Joseph H. Korn, Sergio A. Jimenez

Department of Medicine Faculty Papers

We investigated the participation of prostaglandin (PG) E2 in the regulation of the alpha 1(I) procollagen gene expression by tumor necrosis factor alpha (TNF alpha), and interleukin-1 beta (IL-1 beta) in normal adult human lung fibroblasts. TNF alpha (100 units/ml) and IL-1 beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent inhibition of up to 54 and 66%, respectively, of the production of type I procollagen. Preincubation of cultures with indomethacin partially reversed the inhibition of procollagen production induced by the cytokines. Cytokine-stimulated endogenous fibroblast PG accounted for 35 and 68% of the inhibition induced by TNF …

Ms211: Dbase For The Invitational Conference In Houston, Armin Weinberg

Works on Radiation Effects: 1990-2020

This appears to be the master database of the folks invited to our International Conference hosted by TMH, BCM, THMRF etc. in 1993? It is a treasure trove of those we initially invited from both Israel, Japan, former USSR (Russia, Ukraine, etc.) and of course USA! It has phone and institutional affiliations, flights, etc. See more at Armin Weinberg, PhD Papers and its finding aid.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1993), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1993 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following aritcles:

• President's Perspective
• Community Service the Osteopathic Way: Being a DO Means Caring about the Community
• Weaving Community Issues with Medical Practice
• Special Events Fundraising Begins at PCOM
• Campus Briefs
• PCOM in the News
• Microbiology Professors Receive Awards
• Commitment to Medicine and Education Take Alumni around the World
• Class Acts
• Just Published
• In Memoriam
• Coming Events

The Tight Skin Mouse: Demonstration Of Mutant Fibrillin-1 Production And Assembly Into Abnormal Microfibrils, Cay M. Kielty, Michael Raghunath, Linda D. Siracusa, Michael J. Sherratt, Reiner Peters, C. Adrian Shuttleworth, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

Mice carrying the Tight skin (Tsk) mutation harbor a genomic duplication within the fibrillin-1 (Fbn 1) gene that results in a larger than normal in-frame Fbn 1 transcript. In this study, the consequences of the Tsk mutation for fibrillin-containing microfibrils have been examined. Dermal fibroblasts from Tsk/+ mice synthesized and secreted both normal fibrillin (approximately 330 kD) and the mutant oversized Tsk fibrillin-1 (approximately 450 kD) in comparable amounts, and Tsk fibrillin-1 was stably incorporated into cell layers. Immunohistochemical and ultrastructural analyses of normal and Tsk/+ mouse skin highlighted differences in the gross organization and distribution of microfibrillar arrays. Rotary …

Effect Of Protein Kinase C Inhibitors And Activators On Corneal Re-Epithelialization In The Rat, A. Hirakata, A. G. Gupta, A. D. Proia

Osteopathic Medicine, Jerry M. Wallace School of

PURPOSE: To examine the ability of protein kinase C (PKC) inhibitors and activators to influence the rate of corneal re-epithelialization in the rat. METHOD: Rat corneas with 3 mm diameter central epithelial abrasions were organ-cultured in control medium or in medium with inhibitors or activators of PKC. RESULTS: In control corneas, the defect was completely re-epithelialized by 25 hr. In the presence of the PKC inhibitors staurosporine (100 nM), sphinganine (50 mumol/l), or H-7 (100 mumol/l) there were significantly larger epithelial defects than in controls after 5-25 hr of incubation. Re-epithelialization rates were similar to control corneas when the incubation …

Oncolog, Volume 38, Number 01, January-March 1993, Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Texas Outreach Program offers neuroblastoma screening in infant
• Cryosurgery for prostate cancer shows promise in pilot study
• Clinicians' ability to predict cancer risk may lie in new assay

Oncolog, Volume 38, Number 03, July-September 1993, Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Liposomal cisplatin analogue is less toxic and more effective than cisplatin
• Physicians can help allay fear by helping patients understand cancer risk
• The physician's role in smoking cessation

The Role Of Sn-1,2-Diacylglycerol In Insulin-Stimulated Glucose Transport In Rat Skeletal Muscle, Kevin Paul Boggs

MUSC Theses and Dissertations

Insulin stimulates glucose transport into skeletal muscle upon binding to its cell surface receptor. The signals which stimulate transport are unknown. Studies of insulin's effects on muscle cell lines and adipocytes suggest that increases in sn-l,2-diacyglycerol (DAG) content may mediate insulin-stimulated glucose transport. To test this, the effect of insulin on muscle DAG content was measured. DAG increased in diaphragm and soleus muscles exposed to insulin in vitro and in diaphragm in vivo. However, the supraphysiologic insulin dose (60 nM) and incubation time required (10 min) are not consistent with a role for DAG as a mediator of insulin stimulated …

Good Grief! Coping With Death And Dying In A Hospice Situation, Pegg Warnick

Masters Theses

The purpose of this qualitative study is to discover and examine the coping strategies concerning death and dying from the perspectives of hospice patients and hospice volunteers. A review of applicable literature, informal but structured interviews and participant observation are procedures for the study. The focus of the study lies in three areas: what are the internal attributes used to cope?; what are the external support systems used to cope? and, what are the adjustments in personal goals? Research for this study was patterned after Hegge's study (1991) who surveyed the coping strategies of the recently widowed elderly. The instruments …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1992), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1992 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: PCOM Gains Momentum for Future Challenges
• Postgraduate Program Continues to Grow
• $1 Million Gift Sets Pace for New Fundraising Campaign
• Leonard H. Finkelstein, '59, Receives ACOS 'Distinguished Surgeon Award'
• Exhibits and Poster Sessions
• PCOM Wishes its Best to an Outgoing Dean
• Classic Wisely
• From Colleagues and Co-Workers
• Orchestrating a Life of Music and Medicine
• Rockwell Collector Turns Museum Owner
• Just Published
• Class Acts
• In Memoriam
• Coming Events

Role Of Insulin-Like Growth Factor-I In The Autocrine Regulation Of Cell Growth In Tt Human Medullary Thyroid Carcinoma Cells, Kuo-Pao P. Yang, Naguib A. Samaan, Yi-Fan Liang, Socorro G. Castillo

Henry Ford Hospital Medical Journal

Since the TT human medullary thyroid carcinoma cell line required fewer exogenous growth factors (serum), we investigated whether this line has an autocrine mechanism by examining the effects of antibodies directed toward insulin-like growth factor I (IGF-I) and its receptor on TT cell growth in serum-free conditions. Treating cells with anti-IGF-I antibody for four days reduced the cell number by more than 50% compared with a nonimmune IgG control. Furthermore, a monoclonal antibody to the IGF-I receptor suppressed DNA synthesis when determined by a [³H]thymidine incorporation assay. Exogenous IGF-I (20 ng/mL) stimulated [³H]thymidine incorporation in serum-free …

Alternative Splicing Of Human Prostaglandin G/H Synthase Mrna And Evidence Of Differential Regulation Of The Resulting Transcripts By Transforming Growth Factor Beta 1, Interleukin 1 Beta, And Tumor Necrosis Factor Alpha., Arturo Diaz, Anthony M. Reginato, Sergio A. Jimenez

Department of Medicine Faculty Papers

Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of this clone showed that (a) it contained the entire translated region of PGG/HS and (b) it displayed an in-frame splicing of the last 111 base pairs encoded by exon 9, which resulted in the elimination of the N-glycosylation site at residue 409. Polymerase chain reaction amplification with specific oligonucleotides of reverse-transcribed mRNA from diverse human tissues and cultured cells yielded …

Urban Health And The Social Contract: Poverty, Race, And Death, H. Jack Geiger

Henry Ford Hospital Medical Journal

No abstract provided.

Training The Urban Health Care Provider: One Department's First Steps, James Schindler

Henry Ford Hospital Medical Journal

As our country faces a national crisis in health care, few have outlined plans to improve the shortage of primary care physicians. This is especially critical in urban areas where sociocultural impacts on health are large. The Department of Family Practice and Community Medicine at the University of Texas School of Medicine in Houston has begun development of a division of Urban Family Medicine to address the special training needs of the urban family practitioner. Subdivisions that have been formed focus on undergraduate curriculum, graduate educational strategies, service, and research and policy to further develop the training model.

Moving From Health Care Research To Action, Claudia R. Baquet, Katherine Marconi, George Alexander

Henry Ford Hospital Medical Journal

Although the United States spends more on health care than any country in the world, access to that care is becoming increasingly difficult. The National Cancer Institute and other federal agencies are sponsoring innovative research for delivering effective medical services, particularly to underserved populations. Models of successful collaboration between private and public sectors concerned with health care can be adapted and implemented at the national, state, and local levels. However, other measures are needed to ensure access to adequate health care for all Americans. Minimal but effective regulations are needed to ensure quality control, reduce duplication of services, and minimize …

The Urban Hospital: Rediscovering Abandoned Values, Thomas W. Chapman

Henry Ford Hospital Medical Journal

No abstract provided.

The Emerging Role Of Htlv-I/Ii And Hiv-1 Among Intravenous Drug Users In Detroit, Anthony F. Ognjan, Chris A. Lewandowski, Bradley T. Belian, John Burczak, Norman Markowitz, Helen Lee, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

During 1987-1988, a seroprevalence study of the human immunodeficiency virus (HIV-1) and the human T-cell lymphoma/leukemia virus (HTLV-l/II) was performed among Detroit intravenous drug users unaffiliated with substance abuse programs. Seroprevalence data along with patient demographic information were compared to a similar study performed in 1985-1986. In the earlier study, 12 (12.5%) of 96 individuals tested positive for HIV-1. Of the 74 available negative samples retested in 1987-1988 for retroviruses, 7 (9.5%) tested positive for HTLV-I/II. Thus, the overall retroviral (HIV-1, HTLV-I/II) seropositive rate for 1985-1986 was 22%. In 1987-1988, 11 (15.7%) of 70 individuals tested positive for HIV-1 and …

Presentation And Evaluation Of Patients With Epidermoid Head And Neck Cancers, Michael S. Benninger

Henry Ford Hospital Medical Journal

Epidermoid cancer of the head and neck occurs most frequently in individuals with predisposing factors for neoplastic development. Primarily these include exposure to smoking and alcohol, although other predisposing factors may he present. Site-speciflc symptoms along with a history of predisposing environmental exposure can direct physicians to suspect head and neck cancer. Endoscopy and ancillary testing are performed for tumor staging and subsequent treatment planning.

Oncolog, Volume 37, Issue 03, July-September 1992, Scott M. Lippman Md, Mark A. Schusterman M.D., Eva Singletary Md, Merrick I. Ross M.D., Daryl Ogden Ms

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Retinoic acid/interferon combination shows promising response rates
• Cross-matching test helps find donors for patients in dire need of platelets
• Silicone gel-filled implants: Women should have the option to choose

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter - January 1992), Philadelphia College Of Osteopathic Medicine

Digest

The Winter - January 1992 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Vision and Values: President’s Perspective
• 1991·92 Annual Fund: A Tradition of Support
• Founders Day 1992
• Emanuel Fliegelman, '42: A Born Teacher with Doctors and Patients
• United Again: Not Getting Older – Getting Better
• HPCOM Brings Health Awareness to the Community
• New Department Created as HPCOM Continues its Mission of Delivering Quality Care
• On Campus
• Just Published
• Class Acts
• In Memoriam
• Coming Events

The Measurement Of Knowledge, Attitudes And Knowledge-Seeking Behaviours Of Women In Relation To The Menopause And Health Related Issues, Amanda Devine

Theses : Honours

Research suggests that women are not well informed about the health related issues which are associated with the menopause. The purpose of this study was to determine women's: current knowledge of the menopause and of the disease osteoporosis; attitudes to estrogen replacement therapy (ERT); frequency of menopausal symptoms; knowledge-seeking behaviours In relation to the menopause; and, open-ended responses to menopausal issues. This study surveyed 70 women who responded to an advertisement in Community Newspapers. Data were collected using a "Knowledge and attitudes to the menopause and health related issues" (KAMHRI) questionnaire. The KAMHRI questionnaire was developed by the researcher and …

Regulation Of Transforming Growth Factor-Beta 1 Gene Expression By Glucocorticoids In Normal Human T Lymphocytes., O. Ayanlarbatuman, A. P. Ferrero, Arturo Diaz, Sergio A. Jimenez

Department of Medicine Faculty Papers

Glucocorticoids (GC) modulate immune function in a number of ways, including suppression of T cell proliferation and other IL-2-mediated T cell functions. These inhibitory effects are similar to those induced by transforming growth factor-beta 1 (TGF-beta 1), a cytokine with potent T cell inhibiting activities. We examined the hypothesis that GC effects may be at least partially achieved through modulation of the expression of the TGF-beta 1 gene in activated T cells. Normal T cells were cultured with or without purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) in the presence or absence of the synthetic GC, dexamethasone (100-200 …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Renovations and New Construction Continue
• PCOM Fundraising Goes Back to Basics
• Curriculum Changes
• President's Perspective
• Geriatric Care to be Stressed Early, Often
• PCOM Hosts Conference in Osteopathic Hospitals and Medical Education
• Unique DO-MBA Program Teaches the Business of Medicine
• PCOM Students Go Far for Rural Clinical Experience
• Where are Our 111 Residents?
• On Campus
• A "3-D" View of the Future
• Class Acts
• In Memoriam
• Coming Events

Prehospital Care Of Acute Myocardial Infarction: A Review, Asit R. Gokli, Jay L. Kovar, Terry Kowalenko, Richard M. Nowak

Henry Ford Hospital Medical Journal

Each year more than 1 million people in the United States suffer from acute myocardial infarction (Ml) with most of the deaths occurring within hours of symptom onset. Over the last 25 years, different prehospital systems have evolved throughout the world which allow early cardiac monitoring and treatment of acute Ml patients. Thrombolytic therapy in acute Ml has been shown to decrease mortality and preserve left ventricular function when administered early after onset of symptoms. The potential role of Emergency Medical Services or Mobile Coronary Care Units in achieving early thrombolysis is under investigation. Several studies of prehospital interventions to …

Expression Of A Human Cartilage Procollagen Gene (Col2a1) In Mouse 3t3 Cells., Leena Ala-Kokko, James Hyland, Carol Smith, Kari I. Kivirikko, Sergio A. Jimenez, Darwin J. Prockop

Department of Medicine Faculty Papers

Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes. Here, two DNA constructs were designed so that the promoter region of the gene for the pro-alpha 1(I) chain of human type I procollagen drove expression of the human type II procollagen gene in mouse NIH 3T3 cells, a culture line that normally synthesizes type I procollagen but not any cartilage-specific protein such as type II procollagen. Both constructs were expressed as both mRNA and protein. In clones expressing the construct at high levels, …

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1991), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Two Highest Ranking Medical Officers Receive Honorary Degrees - Brig. Gen. Ronald R. Blanck & Rear Admiral Hugh P. Scott
• Second Career Dos are among PCOM's Outstanding Graduates
• Bright Future on the Horizon as Master Facility Plan Begins
• Tackling Tough Issues
• Osteopathic Medicine + Research = Challenging Career Path
• On Campus
• New Appointments
• Just Published
• Class Acts
• In Memoriam
• Coming Events

Assessment Of Methylprednisolone Purging Efficacy On Daudi Burkitt Lymphoma Cells From Normal Bone Marrow, Nalini Janakiraman, Loreen M. Niewenhuis

Henry Ford Hospital Medical Journal

Studies on normal bone marrow and Daudi Burkitt lymphoma cells were performed to determine the efficacy of selective, in vitro chemopurging with methylprednisolone (MP). We found that MP reduces the numher of lymphoma cells without significant damage to bone marrow cells. This information is important because we need to improve the existing in vitro purging regimens used to cleanse autologous marrows of metastatic disease before transplantation into cancer patients who have received high-dose chemotherapy. Normal human bone marrow (NBM) and Daudi lymphoma cells were trealed in parallel with various purging regimens. NBM death was evaluated using soft-agar culture, while Daudi …

Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs

Dartmouth Scholarship

Concentrations of Mycobacterium avium-M. intracellulare ranging from 10(-1) to 10(3) CFU/ml were added to blood, placed in Isolator tubes, and held at room temperature for intervals ranging from 4 h to 56 days before being processed (centrifugation and culture on Middlebrook 7H10 agar). At all concentrations tested, M. avium-M. intracellulare was recovered after hold times ranging from 4 h to 7 days; the number of final CFU actually increased progressively for hold times of 8 h or more. Hold times of up to 7 days did not increase the time from processing to the first appearance of visible colonies. At …