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The Role Of Social Support Networks In The Independent Functioning Of Elderly Persons, Maree Gabbedy

Theses : Honours

There is conclusive evidence which highlights the importance of physical and mental health in the ability of elderly persons to function within society, and elderly persons who require services to maintain their independence, are assumed to have lower levels of functioning than persons who do not apply for, or require assistance. Individuals, however, are rarely totally independent, as most people are involved in social networks, where the reciprocal exchange of money, emotional support, goods and services are exchanged with friends family and neighbours. This study, examined the role of social support networks in the independent functioning of the elderly, in …

Stimulation Of Alpha 1(I) Procollagen Gene Expression In Nih-3t3 Cells By The Human T Cell Leukemia Virus Type 1 (Htlv-1) Tax Gene., E. Munoz, D. Suri, S. Amini, K. Khalili, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

The mechanisms that regulate the expression of genes encoding extracellular matrix proteins in fibroblasts and other mesenchymal cells have remained elusive. Studies from several laboratories have indicated that Tax, a trans-regulatory protein from the human T cell leukemia virus type I not only augments viral gene expression but also triggers the expression of various cellular genes. Here, we examined the hypothesis that the expression of collagen genes may also be modulated by Tax. NIH-3T3 cells were simultaneously transfected with a Tax expressor plasmid and a chimeric construct containing regulatory sequences (-804 to +42 bp) of the alpha 1(I) procollagen gene …

Biochemical And Molecular Characterization Of The Prostate-Specific Membrane Antigen (Psma), John Karl Troyer

Theses and Dissertations in Biomedical Sciences

Prostate cancer is the most common malignancy and the second leading cause of cancer death in males in the United States. Additionally, the number of deaths attributed to prostate cancer is increasing at a rate of approximately 8% a year. Development of new diagnostic and therapy strategies are needed in order to improve the life expectancy of patients with this disease. One tool which may allow for improvements in prostate cancer diagnosis and therapy is the monoclonal antibody (MAb) 7E11-C5.3 which was first described in 1987. Since then, the antigen recognized by MAb 7E11-C5.3 has been named the prostate specific …

Expression Of Genes Encoding Antioxidant Enzymes In Preimplantation Mouse And Cow Embryos And Primary Bovine Oviduct Cultures Employed For Embryo Coculture., M B Harvey, M Y Arcellana-Panlilio, X Zhang, G A Schultz, A J Watson

Obstetrics & Gynaecology Publications

Preimplantation embryos from a variety of mammalian species contrast markedly in their response to culture in vitro. Murine preimplantation embryos display a wider tolerance than other mammalian species to culture environments, and this has contributed to the development of several effective defined culture media. Embryo coculture on somatic cells remains the most effective method of supporting reasonable rates of bovine preimplantation development in vitro. The patterns of gene expression for several antioxidant enzymes during preimplantation murine and bovine development were examined by use of the reverse transcription-polymerase chain reaction technique to determine whether the differential developmental capacity of mammalian preimplantation …

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1995), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1995 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Commencement ‘95
• Awards and Kudos
• Graduation Snapshots
• College Board Profile
• Alumni Board Profile
• Alumni Making News
• Capital Campaign Developments
• Student Focus
• PCOM Bookstore Mail Order Catalog
• Campus Update
• Just Published
• Class Acts
• Coming Events

Identification And Characterization Of Mitochondrial Dna Variants In Alzheimer's Disease, Natasha Singh Hamblet

Theses and Dissertations in Biomedical Sciences

Alzheimer's Disease (AD) is a complex neurodegenerative disorder that affects a significant portion of the human population regardless of ethnicity or gender. A mitochondrial hypothesis of AD has been proposed based on a number of studies which establish altered oxidative phosphorylation (OXPHOS) and ATP synthesis in AD tissue. ATP demand is most prevalent in the brain; damage to OXPHOS could severely impair brain metabolism, thereby leading to a decline in cognitive function. Four out of five complexes in the OXPHOS pathway are partly encoded by mitochondrial DNA (mtDNA); thus, this may be a crucial site of lesions that alter brain …

Predicting Intentions Of Physical Therapy Students To Practice Primary Prevention, Sharon Potter Anderson

Loma Linda University Electronic Theses, Dissertations & Projects

Physical therapy (PT) has traditionally been a hands-on, tertiary-care field. Although the American Physical Therapy Association has mandated a broader perspective, little primary prevention is yet being reported in the U. S. An attitude change toward prevention must occur if physical therapists can be expected to become involved in preventive physical therapy. The purpose of this project was to determine predictors of physical therapy student intention to perform primary prevention with a questionnaire based on Ajzen's Theory of Planned Behavior. The theory uses attitude, subjective norm and perceived control to predict intention based on beliefs and strength of beliefs in …

Uhs-Communicator: May/June/July 1995, University Of Health Sciences College Of Osteopathic Medicine, Uhs-Com Alumni Association

Communicator (1991-2012)

Contents: 1995 Commencement -- UHS Foundation Contributors -- Mary Lou Butterworth, D.O. Accepts Position as Acting UHS Foundation President -- Oklahoma City Bombing -- One Graduate's Success: Mary Sue Kendrick, D.O. -- News -- Alumni Association's Corner of the World.

Moraxella (Branhamella) Catarrhalis: A Molecular Epidemiology Study, Lyndell R. Gill

Electronic Theses and Dissertations

Moraxella (Branhamella) catarrhalis is the third-most-frequently isolated microorganism associated with acute exacerbations of chronic bronchitis in patients during their stay at the Mountain Home VA Medical Center (MHVAMC). In order to develop a practical, epidemiologically-meaningful typing method for M. (B.) catarrhalis, we tested two methods based on analysis of chromosomal DNA for typeability, reproducibility, and ability to differentiate between unrelated strains (discriminatory power, D). M. (B.) catarrhalis isolants from MHVAMC from 7/1/87-6/30/88 were grown overnight in broth and embedded in agarose. DNA was isolated by standard methods. The DNA was subjected to: (1) restriction endonuclease digestion (with either Bgl II …

Ms211: First Trip To Kazakhstan Executive Summary, Armin Weinberg

Works on Radiation Effects: 1990-2020

This Executive Summary report gives a synopsis of our FIRST trip from February 12-21, to the city of Semipalatinsk, Kazakhstan that established the AIHA, TMH, BCM partnership. Great first impressions and orientation to what follows. A lot of prep went into this including getting letters from key Texas players including one from Governor George W. Bush, Texas to Governor Galimzhan B. Jakianov. ee more at Armin Weinberg, PhD Papers and its finding aid.

Ms211: Working Notes From First Trip To Kazakhstan, Armin Weinberg

Works on Radiation Effects: 1990-2020

Includes great material & notes eg, "ADW and CL returned to Semipalatinsk with BT’s car and driver. Unfortunately while returning they hit a patch of ice and ended up in a snowy ditch. Fortunately this occurred near one of the few villages along the way and a passing truck was able to pull them out. The good reflexes and driving skills of the driver kept them from overturning. ML and MR hired a car and driver from Kuchartov and returned later after completing the hospital survey" I (ADW) gave the drive $100 for pulling us out it was below zero …

Some Observations On The Structure Of Encrusting Biofilms Of Proteus Mirabilis On Urethral Catheters, C. Winters, D. J. Stickler, N. S. Howe, T. J. Williams, N. Wilkinson, C. J. Buckley

Cells and Materials

A physical model of the bladder has been used to study the process of urinary catheter encrustation. Techniques have been devised for the preparation of sections through these encrustations in situ on the luminal surfaces of catheters and for mapping the distribution of calcium and magnesium in the biofilms. Transmission electron microscopy on these sections showed struvite-like crystals lying in the matrix and in direct contact with the catheter surface. Calcium phosphate ("bioapatite") was distributed throughout the film and many of these amorphous particles appear to have cells at their cores. Freeze-substituted sections of biofilms also showed electron dense materials …

Ms211: News Clips Re Nuclear Waste Mid-1990s, Armin Weinberg

Works on Radiation Effects: 1990-2020

Early on and still today what and how to deal with nuclear waste of various types remains unsettled. Yet we continue to rely on nuclear sources for medical, societal, energy and military applications. See more at Armin Weinberg, PhD Papers and its finding aid.

Media Components Influence Viral Gene Expression Assays In Human Fetal Astrocyte Cultures, Micheline Mccarthy, Charles Wood, Larisa Fedoseyeva, Scott R. Whittemore

Nebraska Center for Virology: Faculty Publications

In vitro neurovirological studies of viral infectivity or viral gene expression may be confounded by the mulHple neural cell types and/or fibrob last contamination present in early passage cultures prepared from dissociated human central nervous system (eNS) tissue. We have developed highly enriched astrocyte cultures for neurovirological study by culturing in a serum-free defined medium, 816, supplemented with basic fibroblast growth factor (FGF-2). Subculture in this medium selects against fibroblast proliferation and favors sustained proliferation of a highly enriched glial fibrillary acidic protein (GFAP)-positive cell population. These astrocytes support productive replication of cytomegalovirus (CMV) and transient expression of transfected CMVand …

Oncolog, Volume 40, Number 03, July-September 1995, Kathryn L. Hale, Vickie` J. Williams, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• M. D. Anderson leads the fight against bone pain from metastatic cancer
• New computer program enhances the surgeon-patient consultation
• Bladder cancer: molecular markers may guide treatment

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1995), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 1995 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective
• Joining a Distinguished Few: Lester Eisenberg, DO, ‘38
• Alumni Association Certificate of Honor Recipients
• Founders Day is Another ''Classy" Reunion!
• Spirits Ride High at 99th Annual AOA Convention
• Students Make PCOM Proud
• PCOM Profile: James H. Black, DO
• Campus Update
• Just Published
• Class Acts
• In Memoriam
• Coming Events
• Phi Sig Fraternity Inducts Honorary Members

Randomized Trial Of Erythromycin And Azithromycin For Treatment Of Chlamydial Infection In Pregnancy., M F Rosenn, G A Macones, N S Silverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The purpose of this study was to compare erythromycin and azithromycin in the treatment of chlamydial cervicitis during pregnancy with regard to efficacy, side effects, and compliance.

METHODS: In a prospective manner, 48 pregnant patients with cervical chlamydial infections diagnosed by routine screening tests were randomly assigned to receive either erythromycin, 500 mg q.i.d. for 7 days (N = 24), or azithromycin, 1 g as a one-time dose (N = 24). All sexual partners were given prescriptions for doxycycline, 100 mg b.i.d. for 7 days. The treatment efficacy was assessed by follow-up chlamydia testing 3 weeks after the therapy …

Perceptions Of Control And Satisfaction With Hospital Birth Experiences For First-Time Mothers, Clelia Tedeschi

Theses : Honours

Satisfaction with childbirth is associated with women's future emotional wellbeing. This study examined whether first- time mother's antenatal expectations, postnatal evaluations of control during labour and delivery, and the discrepancy between expectations and evaluations were significant predictors of women's satisfaction with their childbirth experiences. The effect of medical interventions (e.g., obstetrical interventions and pain relief medication) on women's perceptions of control and satisfaction was also examined. The purposive sample of eighty first-time mothers, mean age 26 years (excluding women who had caesareans) delivered at the public hospital where they attended antenatal classes. During their fourth antenatal class women completed a …

Long Term Restoration Of Peak Torque, Endurance And Muscle Activation Post Anterior Cruciate Ligament Reconstruction, Darryl Alan Turner

Theses : Honours

In recent years, Accelerated Rehabilitation (A.R.) protocols have been used following Anterior Cruciate Ligament (A.C.L.) reconstructions, the longer term effects of these programs are seldom analysed. This study examined musculoskeletal mechanisms that might affect long term functional restoration, the control subjects (n = 19) of mixed age and gender, had no previous knee deficiencies and were recreationally fit. The experimental subjects (n = 17) had undergone intra-articular A.C.L reconstruction, using bone patellar-tendon bone grafts performed by the same surgeon and had also participated in the A.R. protocol, similar to that described by Shelbourne and Nitz (1990). The experimental group attended …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1994), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1994 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• ABC’s of Medical Education
• New Curriculum: Making Students Better Doctors
• First OMM Fellowship Recipients Named
• Herbert Lotman: Chairman of the Board
• PCOM Profile: Alexander E. Rodi, DO
• PCOM Annual Report 1994: Building for the Future
• Academic Update
• The PCOM Mission
• Master Facilities Plan
• PCOM Financial Review
• Officers of the College
• PCOM Board of Trustees
• PCOM Alumni Recognized at ACOS Convention
• PCOM Celebrates National Primary Care Day
• PCOM Golf Classic
• PCOM Appoints Senior Vice President
• Evening of Art Raises Funds for PCOM Health …

Psychosocial Determinants Of Age-Appropriate Immunizations Of Infants In Norfolk, Virginia, Hoda Youssef Atta

Health Services Research Dissertations

This study represents an investigation of psychosocial factors affecting age-appropriate immunizations of infants in Norfolk, Virginia. A household survey was conducted in Norfolk, Virginia, from 4/93-8/93, to assess immunization coverage of children 12-30 months of age. This survey included a total of 389 children in the target age range. A subset of 201 mothers were randomly selected and reinterviewed to assess their knowledge and attitudes and the relationships of these factors to age-appropriate immunizations at 12 months of age. Sixty-two percent of children were not age-appropriately immunized at 12 months of age. Almost all mothers (99%) considered vaccines to be …

An Assessment Of Personal Characteristics, Job Satisfaction And Semantic Descriptors Of Virginia Acute And Tertiary Care Hospitals' Chief Executive Officers, Justin C. Matus

Health Services Research Dissertations

The purpose of the study was to identify the determinants of job satisfaction of Virginia Hospital CEO's and to identify those descriptors that best characterize the role of the hospital CEO as defined by the CEO's themselves. The study sample consisted of all hospital CEO's in Virginia as listed by the Virginia Hospital Association. The study employed a four part survey instrument that investigated four major areas: (1) personal and hospital demographics; (2) self rated performance; (3) a semantic scale measuring the concept of Hospital CEO; and (4) The Minnesota Satisfaction Questionnaire. A survey was mailed to 119 CEO's. The …

Polyclonal Infections Due To Mycobacterium Avium Complex In Patients With Aids Detected By Pulsed-Field Gel Electrophoresis Of Sequential Clinical Isolates., Alexander M. Slutsky, Robert D. Arbeit, Thomas W. Barber, Josiah Rich, C Fordham Von Reyn

Dartmouth Scholarship

Invasive infection with organisms of the Mycobacterium avium complex (MAC) is common among patients with advanced human immunodeficiency virus infection. In previous studies, we analyzed multiple individual colonies of MAC isolated from specimens obtained at the same time and observed that 14 to 20% of patients are simultaneously infected with more than one strain. In this study, we examined sequential isolates from 12 patients with AIDS who had two or more MAC isolates available from clinical specimens collected more than 1 week apart; the intervals between the first and last specimens ranged from 8 to 192 (median, 46) days. For …

Functional Analysis Of Human Alpha 1(I) Procollagen Gene Promoter. Differential Activity In Collagen-Producing And -Nonproducing Cells And Response To Transforming Growth Factor Beta 1., Sergio A. Jimenez, John A. Varga, Anne Olsen, Liye Li, Arturo Diaz, Janet Herhal, Julie Koch

Department of Medicine Faculty Papers

To gain a further understanding of the regulation of human type I collagen gene expression under physiologic and pathologic conditions, we characterized 5.3 kilobase pairs (kb) of the human alpha 1(I) procollagen gene promoter. A series of deletion constructs containing portions of the alpha 1(I) procollagen 5'-flanking region (with end points from -5.3 kb to -84 base pairs (bp)) ligated to the chloramphenicol acetyltransferase (CAT) reporter gene were transiently transfected into NIH/3T3 cells. Maximal CAT activity was observed with constructs having 5' end points from -804 to -174 bp. A further 5' deletion to -84 bp caused a marked reduction …

Preimplantation Development Of In Vitro-Matured And In Vitro-Fertilized Ovine Zygotes: Comparison Between Coculture On Oviduct Epithelial Cell Monolayers And Culture Under Low Oxygen Atmosphere., A J Watson, P H Watson, D Warnes, S K Walker, D T Armstrong, R F Seamark

Obstetrics & Gynaecology Publications

The roles of medium composition, serum source, embryo coculture, and culture under low O2 conditions on the development of in vitro-matured and in vitro-fertilized (IVMF) ovine zygotes were investigated in three separate experiments. In the first experiment, the proportion of cocultured IVMF zygotes developing to the blastocyst stage was significantly higher (38.0% vs. 3.5%; p < 0.05) than that of non-cocultured zygotes treated within three embryo culture media (TCM-199 + 10% fetal bovine serum [FBS]; bicarbonate-buffered, glucose-free synthetic oviduct fluid medium [mod-SOFM] + 10% FBS; and bicarbonate-buffered BSA-free Tyrode's salt solution [mod-TALP] + 10% FBS) under a 5% CO2 atmosphere in air. In a second experiment, a significantly higher (p < 0.05) proportion of cocultured zygotes placed in TCM-199 medium survived to the blastocyst stage (37.4% blastocysts vs. 23.4% in mod-SOFM). No significant effect of serum (FBS vs. human serum [HS]) was observed on embryonic development, but coculture was confirmed to exert a significant influence on development to the blastocyst stage. In the final experiment, survival of the embryo under a reduced oxygen (5% CO2:5% O2:90% N2) atmosphere was investigated. In contrast to results in the initial experiments, embryonic survival was significantly higher (p < 0.05) in the non-cocultured treatment groups (21.9% blastocysts vs. 0.4% for cocultured zygotes). Serum source also had a significant (p < 0.05) influence upon the development of non-cocultured zygotes: 32.3% of zygotes cultured with HS progressed to the blastocyst stage vs. 11.5% of zygotes cultured in FBS-supplemented medium. These results have characterized two distinct culture environments, each capable of supporting the development of high frequencies of unselected IVMF zygotes to the blastocyst stage in vitro.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1994), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1994 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: The Osteopathic Education Model
• Health Care Reform: PCOM Retools For The Big Picture
• Changing the Face of Medical Education
• Other Views on Health Care Reform
• Doctor’s Visit Minus Fear = Happy Children
• Founders Day Honorees: A'weekend in the Spotlight
• Clinical Learning Lab Gets Rave Reviews
• Faculty Profile
• Rugby Madness
• Just Published
• Class Acts
• Obituaries
• Coming Events

A View Of Hiv--Infection In Karachi, Naila Kayani, Aamir Sheikh, Asif Khan, Chhotoobhai Mithani, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

A prospective study on the prevalence of HIV-l infection in Karachi, Pakistan was conducted over a period of six years (1986-1992). Over 15,000 individualsamples and more than 32,000 donor units of individuals residing in Karachi at the time of sample co llection were tested for HIV-I infection by our screening test EIA which revealed a positivity rate of 0.23% and 0.003% in individual and donor units respectively by Western Blot. We divided patients into four groups A,B,C and D based on the most plausible cause of transmission. The largest number of positive patients belonged to group B, who were of …

The Prevalence Of Behavioural Risk Factors Associated With Sudden Infant Death Syndrome, Ann M. Callaghan

Theses : Honours

Sudden Infant Death syndrome (SIDS) is a major cause of death in the first year of life. In Western Australia (WA), two infants in every thousand live births die from SIDS each year. The aim of this study was to ascertain the prevalence in WA of three risk factors which have been associated with SIDS, namely prone lying, maternal smoking and lack of breast feeding. In addition the study sought to determine the significant influences that encourage change in infant care practices by parents. The study obtained information from child health nurses and midwives regarding the advice they provide on …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1993), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1993 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Perspective: PCOM’s Mission: Nation’s Priority
• Renovations and Innovations Highlight Beginning of Academic Year: Doctors From Day One: Learning More than Lectures and Labs
• PCOM Launches Graduate Biomedical Sciences Program
• Campus News
• Letters to the Editor
• Primary Care and Plastination Topics for Recent Grants
• First Golf Outing a Classic!
• Just Published
• Class Acts
• In Memoriam
• Coming Events

The Effect Of The Cooper Wellness Program In Promoting Long- Term Lifestyle Behavior Changes, Ernesto P. S. Medina Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Most research on health behavior change programs examines their effectiveness in producing initial behavior changes, but fails to evaluate long-term maintenance of those changes. This study examined the effectiveness of the Cooper Wellness Program (CWP) in Dallas, Texas, in promoting maintenance of lifestyle behavior changes for one year or longer in the areas of diet, exercise, and stress management.

The CWP offers an intensive live-in lifestyle behavior modification program in four-, seven-, or 13-day formats. Data were collected from 223 individuals who attended the CWP between January, 1989, to February, 1992. The study addressed the following areas: 1) long-term maintenance …