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Articles 15151 - 15180 of 24832
Full-Text Articles in Entire DC Network
Prevalence Of Comorbidities And Associated Factors In Acromegaly Patients In The Turkishpopulation, Mustafa Can, Muhammet Kocabaş, İlker Çordan, Hati̇ce Çalişkan Burgucu, Meli̇a Karaköse, Mustafa Kulaksizoğlu, Feridun Karakurt
Prevalence Of Comorbidities And Associated Factors In Acromegaly Patients In The Turkishpopulation, Mustafa Can, Muhammet Kocabaş, İlker Çordan, Hati̇ce Çalişkan Burgucu, Meli̇a Karaköse, Mustafa Kulaksizoğlu, Feridun Karakurt
Turkish Journal of Medical Sciences
Background/aim: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acromegaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly. Materials and methods: In the study, 96 patients who were followed up with the diagnosis of acromegaly were included. Clinical, laboratory and imaging features, and accompanying comorbidities of the patients were recorded from the patient files. Results: Of the patients included in the study, 63 (65.6%) were female and 33 …
Severe Chronic Periodontitis Is Not Common In Acromegaly: Potential Protective Role Ofgingival Bmp-2, Si̇bel Başçil, Özlem Turhan İyi̇di̇r, Ni̇lüfer Bayraktar, Melek Eda Ertörer, Nesli̇han Başçil Tütüncü
Severe Chronic Periodontitis Is Not Common In Acromegaly: Potential Protective Role Ofgingival Bmp-2, Si̇bel Başçil, Özlem Turhan İyi̇di̇r, Ni̇lüfer Bayraktar, Melek Eda Ertörer, Nesli̇han Başçil Tütüncü
Turkish Journal of Medical Sciences
Background/aim : Advanced chronic periodontitis is observed rarely in acromegaly. Periodontal tissue including the alveolar bone is seemed to be spared from the systemic metabolic derangements of bone in this patient population. Chronic elevation of growth hormone, IGF-1, and bone morphogenetic proteins may play a role in periodontal tissue regeneration in acromegalics. In this study, we aimed to evaluate the potential roles of local gingival bone morphogenetic proteins (BMP) in periodontal tissue pathology in acromegaly. Materials and methods: Thirty-five patients with acromegaly and 22 healthy subjects were recruited. All the participants were examined by the same periodontologist for the diagnosis …
The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel
The Role Of Lateralisation And Sex On Insular Cortex: 3d Volumetric Analysis, Fatma Öz, Ni̇yazi̇ Acer, Ni̇han Katayifçi, Güneş Aytaç, Kami̇l Karaali̇, Muzaffer Si̇ndel
Turkish Journal of Medical Sciences
Background/aim: The insula has attracted the attention of many neuroimaging studies because of its key role between brain structures. However, the number of studies investigating the effect of sex and laterality on insular volume is insufficient. The aim of this study was to investigate the differences in insular volume between sexes and hemispheres. Materials and methods: A total of 47 healthy participants [24 males (20.08 ± 1.44 years) and 23 females (19.57 ± 0.90 years)] underwent magnetic resonance imaging (MRI). Imaging was performed using the 3T MRI scanner. The insular volume was measured using the Individual Brain Atlases using Statistical …
Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven
Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven
Turkish Journal of Medical Sciences
Introduction: There are few studies that compare the cadaver dissections with the medical simulators in means of talent improvement. Therefore, the aim of this study is to find out if using cadaver dissections is still the golden standard for surgical training or using the medical simulators in surgery could replace cadaver dissections. Materials and methods: The study is conducted during the European Orthopaedics & Traumatology Education Platform accredited Shoulder Club International Cadaver Course including a number of 34 orthopedics trainees. The participants were randomly divided into two groups to be trained with the simulator (Group 1) and on cadavers (Group …
Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l
Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l
Turkish Journal of Medical Sciences
Background/aim: Gastrointestinal (GI) system cancers are frequent among older adults and it is still difficult to predict which are at increased risk for postoperative complications. Frailty and sarcopenia are increasing problems of older population and may be associated with adverse outcomes. In this study we aimed to examine the effect of sarcopenia and frailty on postoperative complications in older patients undergoing surgery for GI cancers. Materials and methods: Forty-nine patients admitted to general surgery clinic with the diagnosis of gastrointestinal system cancers were included in this cross-sectional study. Frailty status was assessed using the Edmonton Frail Scale (EFS). Sarcopenia was …
Comparison Of Frozen-Thawed Embryo Transfer Protocols In Patients With Previouscycle Cancellation Due To Uterine Peristalsis: A Pilot Study, İlknur Selvi̇, Mehmet Erdem, Erhan Demi̇rdağ, Müni̇re Funda Cevher Akdulum, Cengi̇z Karakaya, Ahmet Erdem
Comparison Of Frozen-Thawed Embryo Transfer Protocols In Patients With Previouscycle Cancellation Due To Uterine Peristalsis: A Pilot Study, İlknur Selvi̇, Mehmet Erdem, Erhan Demi̇rdağ, Müni̇re Funda Cevher Akdulum, Cengi̇z Karakaya, Ahmet Erdem
Turkish Journal of Medical Sciences
Background/aim: To investigate the optimal protocol for frozen-thawed embryo transfer (FET) cycles in patients who previously had a cycle cancellation due to uterine peristalsis (UP). Materials and methods: Thirty-four patients with previous embryo transfer (ET) cancellation due to UP during artificial cycle (AC) were included retrospectively. In the proceeding cycle, endometrium was prepared with AC (n: 23) in AC-FET group or with stimulated cycle that contains letrozole (L) (n: 11) in L-FET group. Intravenous bolus dose of 6.75 mg atosiban (Tractocile; Ferring Pharmaceuticals, Switzerland) injection was performed to all patients of AC-FET group due to UP ≥ 4/min on the …
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Turkish Journal of Medical Sciences
Background/aim: Magnetic resonance (MR) images, signal intensity ratios calculated using region of interests (ROI) in T2W images by proportioning the dominant myoma to iliac muscle can aid patient selection and, thus, in achieving better outcomes with the uterine artery embolization (UAE) procedure. The present study investigates the association between the success of UAE treatment with signal intensity (SI) ratio of the dominant myoma to the iliac muscle in MR imaging performed prior to the procedure. Materials and methods: This is a retrospective study and included 30 patients who admitted to our clinic between February 2017 and July 2019 due to …
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in …
Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz
Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz
Turkish Journal of Medical Sciences
Background/aim: To evaluate the clinical and histopathological effects of fetal brain tissue derived mesenchymal stem cells (FBTMSC) and fibrin glue (FG) on the facial nerve (FN) regeneration in rats with traumatic FN injury. Materials and methods: Twenty-eight Sprague Dawley rats were included in the study and divided into 4 groups. Traumatic FN injury (FP) was created by a surgical clamp compression to the main trunk of left FN in all groups. In the control group (group 1) no treatment was applied, in group 2 (FBTMSC group) 2 × 106 FBTMSC was injected, in group 3 (FG group) only FG was …
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Turkish Journal of Medical Sciences
Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In GroupII, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and endto-end anastomosis was performed. In Group-IV, …
Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari
Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari
Turkish Journal of Medical Sciences
Backround/aim: Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2 S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2 S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats. Material and methods: Rats were divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg, NaHS50 μmol/kg, and NaHS100 μmol/ kg. After treatment for 7 days intraperitoneally (ip), a single ip …
Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay
Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay
Turkish Journal of Medical Sciences
Background/aim: Sleep deprivation disrupts prepulse inhibition of acoustic startle reflex and can be used to mimic psychosis in experimental animals. On the other hand, it is also a model for other disorders of sensory processing, including migraine. This study aims to assess the effects of sodium valproate, a drug that is used in a variety of neuropsychiatric disorders, on normal and disrupted sensorimotor gating in rats. Materials and methods: Sixty-two Wistar albino rats were randomly distributed into 8 groups. Subchronic and intraperitoneal sodium valproate were administrated to the sleep-deprived and nonsleep-deprived rats by either 50-100 or 200 mg/kg/day. Prepulse inhibition …
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Turkish Journal of Medical Sciences
Aim: The aim of this study is to determine the effects of different concentrations of albendazole and lansoprazole, which were benzimidazole derivatives, on endocrinologic and biochemical parameters in experimental type 2 diabetic (T2D) rats. Materials and methods: In this study, 46 male Wistar Albino rats were used. Animals were divided as healthy control (0.1 mL/rat/day saline, s.c, n = 6), diabetes control (0.1 mL/rat/day saline, s.c, n = 8), diabetes+low-dose albendazole (5 mg/kg, oral, n = 8), diabetes+highdose albendazole (10 mg/kg, oral n = 8), diabetes+low-dose lansoprazole (15 mg/kg, subcutaneous, n = 8), and diabetes+high-dose lansoprazole (30 mg/kg, subcutaneous, n …
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
Turkish Journal of Medical Sciences
Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …
Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman
Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman
Turkish Journal of Medical Sciences
Background/aim: Hyperbaric oxygen therapy (HBOT) causes insulin sensitivity, but the reason for this is not known yet. The aim of the present study was to investigate the effect of HBOT on insulin sensitivity via resistin, plasminogen activator inhibitor-I (PAI-I), and adiponectin. Materials and methods: The study was designed using HBOT and control groups, with eight rats in each group. After 20 days of HBOT under 2.5 atmospheres for 90 min, the fasting insulin (FI), resistin, PAI-I, homeostatic model assessment of insulin resistance scores (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), triglyceride, and high-density lipoprotein cholesterol (HDL-C) …
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Turkish Journal of Medical Sciences
Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of …
Impact Of Covid-19 On Serum Melatonin Levels And Sleep Parameters In Children, Özlem Yayici Köken, Pembe Gültutan, Merve Si̇bel Güngören, Gülsüm İclal Bayhan, Deni̇z Yilmaz, Esra Gürkaş, Hami̇t Özyürek, Ayşegül Neşe Çitak Kurt
Impact Of Covid-19 On Serum Melatonin Levels And Sleep Parameters In Children, Özlem Yayici Köken, Pembe Gültutan, Merve Si̇bel Güngören, Gülsüm İclal Bayhan, Deni̇z Yilmaz, Esra Gürkaş, Hami̇t Özyürek, Ayşegül Neşe Çitak Kurt
Turkish Journal of Medical Sciences
Background/aim: This study aimed to analyze the serum melatonin levels and changes in sleep patterns in pediatric patients with coronavirus disease 2019 (COVID-19). Materials and methods: This study was designed as a descriptive, cross-sectional study. Serum melatonin levels and sleep parameters of children with the diagnosis of COVID-19 who had mild and moderate disease (i.e., COVID-19 group) were compared with those of children admitted with non-COVID-19 nonspecific upper respiratory tract infection (i.e., control group). The sleep disturbance scale for children (SDSC) questionnaire was applied to the participants' primary caregivers to analyze their sleep patterns at present and six months before …
Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇
Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the nonHLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory …
Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel
Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel
Turkish Journal of Medical Sciences
Background and aim: This study aimed to determine the frequency of relapse, the risk factors for relapse, and the correlation of relapse with immunosuppressive regimens in patients with granulomatosis polyangiitis (GPA). Materials and methods: The demographic characteristics, the clinical, laboratory, and radiological findings, the immunosuppressive treatment regimens, and the remission and relapse rates of 50 patients with GPA were obtained retrospectively from medical records. Results: The mean relapse-free survival rates at years 1, 3, and 5 were 82%, 60%, and 50%, respectively. Increased relapse rates were observed in patients who had cavitary lung lesions (52.2% vs. 22.2%, p = 0.04) …
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
Turkish Journal of Medical Sciences
Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for ≥3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (≥2 SDS), advanced bone age, serum 17-OH progesterone 0.05]. …
Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇
Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇
Turkish Journal of Medical Sciences
Background/aim: The present study aimed to determine the association between attention-deficit hyperactivity disorder (ADHD) symptoms severity, fibromyalgia (FM) severity, and QoL. Materials and methods: While the FM group consisted of 113 (74%) patients, the control group consisted of 40 (26%) individuals. FM symptom severity, ADHD symptom severity, and QoL were evaluated using the fibromyalgia impact questionnaire (FIQ), adult ADHD self-report scale (ASRS), and World Health Organization quality of life scale-brief version (WHOQOL-BREF), respectively. Results: It was found that the FM group had significantly higher scores on the ASRS than the control group (p < 0.05). There was a significant difference in FIQ scores and three WHOQOL-BREF domain scores between the FM alone and comorbid FM/high probability of ADHD groups (p < 0.05). We found a negative correlation between ASRS total scores and all other scale scores (except for the social relationships domain score of the WHOQOL-BREF) and a positive correlation between ASRS total scores and FIQ scores in FM patients. ADHD scores would mediate the relationship between depression severity and QoL. Conclusions: Our findings indicated that the presence of ADHD symptoms was related to greater FM symptom severity and poorer QoL. Also, ADHD scores would mediate the relationship between depression severity and QoL.
Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş
Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş
Turkish Journal of Medical Sciences
Background/aim: MicroRNAs (miRNAs) are known up-to-date candidate biomarkers for several diseases. In addition, obtaining miRNA from different body fluids such as serum, plasma, saliva, and urine is relatively easy to handle. Herein we aimed to detect miRNAs as biomarkers for early stage prostate cancer (PC). For this purpose, we used urine and serum samples to detect any significant differences in miRNA profiles between patients and healthy controls. Materials and methods: Total ribonucleic acid (RNA) in urine and serum samples were isolated from eight untreated PC patients, thirty healthy individuals were screened for miRNA profile, and candidate miRNAs were validated. Whole …
20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu
20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu
Turkish Journal of Medical Sciences
Background/aim: Although cutting edge procedures such as cell-free fetal DNA isolation from maternal blood are now available, invasive prenatal tests are still being used extensively for prenatal diagnosis. The study aims to evaluate the demographic data, indications, and cytogenetic results of 9297 results of patients who underwent prenatal invasive testing for genetic analysis that were referred for the last 20 years in a University Medical Genetics Center. Materials and methods: The records of 8363 amniocenteses, 626 chorionic villus, and 308 cordocenteses samples were retrospectively evaluated and analyzed regarding referral reasons, indications and their cytogenetic results. The total numbers and the …
Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz
Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz
Turkish Journal of Medical Sciences
Background/aim: To determine the seroprevalence and evaluate clinical findings and laboratory results of patients prediagnosed with Crimean-Congo hemorrhagic fever (CCHF) in Gümüşhane. Materials and methods: Included in the cross-sectional study were 362 patients (162 female, 200 male) between 0 and 94 years of age, who were followed up after receiving a preliminary diagnosis of CCHF between January 2011 and December 2019. Anamnesis, age, sex, clinical findings, laboratory results, epidemiological and clinical evaluations, severity criteria, risk factor reviews, and a comparison of the suspected negative cases with positive cases were analyzed retrospectively. Patients included in the study were evaluated as RNApositive …
Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n
Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n
Turkish Journal of Medical Sciences
Background/aim: Microsatellite instability tests and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) in the immune checkpoint pathway are the tests that determine who will benefit from immune checkpoint inhibitor therapy. We aimed to show the expression of DNA mismatch repair proteins and PD-1/PD-L1 molecules that inhibit immune checkpoints, to explain the relationship between them, and to demonstrate their predictive role in recurrent and nonrecurrent glioblastoma. Materials and methods: We analyzed 27 recurrent and 47 nonrecurrent cases at our archive. We performed immunohistochemical analysis to determine expressions of PD-1, PD-L1, and mismatch repair proteins in glioblastoma. We evaluated the relationship …
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Turkish Journal of Medical Sciences
Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed …
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Turkish Journal of Medical Sciences
Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (
Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun
Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun
Turkish Journal of Medical Sciences
Background/aim: Tuberculosis is a public health problem that still remains significant. For prevention, diagnosis, and treatment of tuberculosis more effective novel biomarkers are needed. MicroRNAs can regulate innate and adaptive immune responses, alter host-pathogen interactions, and affect progression of diseases. The relationship between microRNA expression and active pulmonary tuberculosis (APT) has not yet been investigated in the Turkish population. We aimed to test the potential diagnostic value of some microRNAs whose levels were previously reported to be altered in APT patients. Materials and methods: Using two different references (U6 and miR-93), we compared the expression levels of potentially important microRNAs …