Digital Commons Network^™

Real-World Anti-Amyloid Therapy Beyond Traditional Symptomatic Populations: A Longitudinal Case Series, Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham

Mathematics & Statistics Faculty Publications

Introduction: Anti-amyloid monoclonal antibodies are approved as disease-modifying therapies for early Alzheimer’s disease (AD), but real-world evidence remains limited, particularly among individuals treated during preclinical or minimally symptomatic stages. This study characterized clinical and biomarker trajectories among anti-amyloid therapy recipients across disease stages.

Method: We conducted a longitudinal retrospective case series of three biomarker-positive individuals from the Alzheimer’s Disease Neuroimaging Initiative who received lecanemab or donanemab. Clinical, cognitive, cerebrospinal fluid, plasma biomarker, and amyloid PET data were examined.

Results: In all three cases, most of the observation period preceded anti-amyloid therapy initiation. Clinical trajectories varied by biomarker profile and treatment …

Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Dextrorphan is a Phase I equine metabolite of dextromethorphan, a widely used anti-tussive / cough suppressant medication marketed and available in numerous over-the-counter formulations in the United States. Dextromethorphan is an Association of Racing Commissioners International (ARCI) drug class 4 penalty class B substance and a Horseracing Integrity and Welfare Authority (HIWU) CONTROLLED S7 B substance and is regulated as such in horse racing. In horses, dextromethorphan is metabolized to its Phase I metabolite, dextrorphan, which is next glucuronidated and the resultant dextrorphan-glucuronide conjugate then excreted at remarkably high concentrations in equine urine. Dextrorphan is therefore at times identified in …

Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige

Epidemiology and Environmental Health Faculty Publications

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …

Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey

Bioelectrics Publications

Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …

Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova

Bioelectrics Publications

Background/Objectives: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis and limited treatment options, highlighting the need for reliable preclinical models for translational research. Although xenograft models are widely used in cancer biology, systematic characterization of subcutaneous ESCC models under defined implantation conditions remains limited. The objective of this study was to systematically compare implantation conditions and define histopathological and growth-related parameters that enable reproducible tumor establishment while maintaining a practical experimental window for therapeutic studies. Methods: We established and characterized a subcutaneous ESCC xenograft model using human ESCC cell line KYSE-30 implanted into immunodeficient J:NU mice. …

Targeting Ptp4a3 And Kvx-053 Mitigates Alcohol-Amplified Sars-Cov-2 Spike Protein-Induced Acute Lung Injury, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Elizabeth R. Sharlow, John S. Lazo, John D. Catavas

Bioelectrics Publications

Introduction: Chronic alcohol exposure is associated with increased vulnerability to acute respiratory distress syndrome (ARDS), and emerging evidence suggests that this susceptibility extends to the severe respiratory manifestations of COVID- 19. The SARS-CoV-2 Spike Protein S1 subunit (S1SP) can independently trigger robust inflammatory and vascular injury responses in the lung, and our prior work demonstrated that chronic alcohol consumption markedly intensifies these effects in mice. PTP4A3 phosphatase is a key regulator of inflammation and endothelial barrier function. In this study, we investigated whether the PTP4A3 inhibitor KVX-053 can counteract alcohol-enhanced S1SP-induced lung injury in K18-hACE2 mice.

Methods: Animals were maintained …

Synergistic Sensitization Of Pancreatic Cancer Cells By Nanosecond Pulsed Electric Fields And Cold Atmospheric Plasma Via Amplifying Ros And Apoptotic Signaling, Zobia Minhas, Edwin A. Oshin, Lifang Yang, Chunqi Jiang, Siqi Guo

Bioelectrics Publications

Pancreatic cancer remains a highly lethal malignancy, with standard therapies offering limited benefits in advanced stages; thus, novel strategies that exploit specific cancer cell vulnerabilities are urgently needed. Building on our previous findings that nanosecond pulsed electric fields (nsPEF) combined with cold atmospheric plasma (CAP) produce enhanced cytotoxicity, this study investigates the molecular mechanisms underlying this synergy. Pan02 pancreatic cancer cells were subjected to nsPEF, CAP, or a combination of both. We assessed cell viability, reactive oxygen species (ROS) production, and mitochondrial integrity using metabolic assays, flow cytometry, and fluorescence microscopy. Apoptotic markers were evaluated via Western blotting and caspase …

Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo

Bioelectrics Publications

Nanosecond electric pulses (nsEPs) are an emerging pulsed-power technology with unique bioelectric characteristics distinct from conventional long-pulse electroporation. As a tunable physical modality, nsEPs can modulate intracellular structures, membrane dynamics, and signaling pathways. Increasing evidence supports nsEPs as a promising non-thermal tumor ablation approach due to their high spatial precision, preservation of critical tissue structures, and minimal adverse effects. One of the most significant discoveries associated with nsEP tumor ablation is the induction of potent systemic antitumor immunity, particularly in situ vaccination (ISV) effects and, in some cases, abscopal effects against distant untreated tumors. Substantial evidence demonstrates that nsEPs can …

Cxcr6+ Natural Killer Cell Immunotherapy Preserves Cd4+ T Helper Cells In Humanized Mice, Naushad Khan, Kayla Frank, Silke Paust

Faculty Research 2026

Human immunodeficiency virus (HIV) persists despite antiretroviral therapy because long-lived viral reservoirs are not eliminated, and ongoing or rebound infection contributes to progressive loss of CD4⁺ T helper cells. Natural killer (NK) cells can acquire adaptive, antigen-experienced functions, including recall responses to HIV envelope protein, suggesting that defined NK-cell subsets may be therapeutically useful against HIV. Because HIV-responsive adaptive NK-cell activity is enriched among CXC chemokine receptor 6-positive (CXCR6⁺) NK cells, we tested whether CXCR6⁺ NK cells provide enhanced antiviral activity and CD4⁺ T-cell protection compared with CXCR6⁻ NK cells. In co-cultures with HIV-infected …

Legislating Infrastructure: A State-Level Model To Accelerate Endometriosis Research And Women's Health Equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, D E Luciano

Faculty Research 2026

Impact statement: A legislatively mandated, statewide endometriosis biorepository integrated within a multidisciplinary endometriosis focused program demonstrates how policy-driven infrastructure can integrate education, clinical care, harmonized biobanking, and translational research to address persistent gaps in women's health in the long term. The Connecticut Endometriosis Working Group (EWG), a group of legislators, researchers, patients, health care providers, and advocates, was established in 2021. The EWG met monthly to discuss strategies to address endometriosis and propose endometriosis specific legislation which has been a turning point. Public Acts 22-33 and 23-67 directed the establishment, governance, and annual reporting of a coordinated endometriosis data and …

Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney

Faculty Research 2026

The combined effects of thousands of genetic polymorphisms account for Alzheimer's disease (AD) genetic risk. Most AD polymorphisms affect gene expression. Thus, the transcriptome, the set of all gene expression levels for every gene in the genome, is a major mediator between the genotype to phenotype. This study uses genotypes, transcriptomes, and clinical phenotypes to identify the transcriptomic signature that mediates the causal effect of genotype on AD. By utilizing a causal inference method known as high dimensional mediation analysis (HDMA) on the Religious Orders Study/Memory and Aging Project (ROSMAP) longitudinal cohort, the genotype, transcriptome, and phenotype data were reduced …

Can Angiotensin Ii Affect The Inflammatory Response Of Human Dental Pulp Cells In Vitro?, Bella Luna Colombini-Ishikiriama, Thiago José Dionisio, Thais Francini Garbieri, Rafaela Alves Da Silva, Sandra Helena Penha Oliveira, Vanessa Soares Lara, Andrew S Greene, Carlos Ferreira Dos Santos

Faculty Research 2026

OBJECTIVE: This study aimed to evaluate the capacity of fibroblasts from permanent and deciduous dental pulp to express inflammatory mediators when exposed to bacterial and inflammatory antigens. It also sought to assess the presence of components of the renin-angiotensin system (RAS) and the potential modulatory role of ANG-II in this response.

METHODOLOGY: Fibroblasts were cultured from the pulp of permanent and deciduous teeth obtained from three adult and four pediatric donors with informed consent. Cells were stimulated with Porphyromonas gingivalis and Escherichia coli lipopolysaccharides (LPS) either alone or in combination with ANG-II and, in some cases, with IL-1β. Gene expression …

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

Race And Racism In Canada’S Immigration Detention System, Efrat Arbel, Prasanna Balasundaram, Hanna Gros, Nana Yanful

All Faculty Publications

Race and Racism in Canada's Immigration Detention System is the first comprehensive, independent study to examine race and racism in Canada's immigration detention system. Grounded in rigorous legal analysis and qualitative research, the study draws on interviews with 50 participants, including people with lived experience of immigration detention, as well as lawyers, paralegals, and service providers who work in immigration detention. The research was guided by an advisory board of people with lived-experience in immigration detention and co-led by a collaborative research team.

Call Off The Dogs: Rethinking Sniffer Dog Searches In Canadian Criminal Law, Sara Gordon

All Faculty Publications

The Supreme Court of Canada has repeatedly held that police sniffer dog searches are Charter-compliant based on a low standard of reasonable suspicion because they are minimally intrusive, narrowly targeted, and can be highly accurate. Since the Court last considered their constitutionality, however, extensive empirical research has fundamentally challenged assumptions about the reliability and accuracy of police sniffer dogs, as well as the harm to individuals subjected to these searches. Moreover, the phenomenon of handler cueing can operate to transmit a police officer’s unconscious biases—even those they would consciously reject—to their dogs, further reducing accuracy and leading to false alerts …

Bloodstain Pattern Analysis And The Gatekeeping Role Of Canadian Courts, Sara Gordon

All Faculty Publications

Despite its long history of admission throughout North America, there appears to be no published Canadian case subjecting bloodstain pattern analysis to the special scrutiny Canadian law demands for novel or contested scientific evidence. Instead, courts have admitted the evidence based largely on the training and experience of forensic examiners, taking it for granted that the field is sufficiently reliable. However, the application of the White Burgess framework reveals that there are serious and severe concerns about the underlying scientific validity of the technique which should render it generally inadmissible. At Stage One of White Burgess, bloodstain pattern analysis fails …

Model Law? Template Legal Culture And The Global Production Of Environmental Law, Natasha Affolder

All Faculty Publications

Lawyers build from templates. Accounts of how law is made rarely mention them. New legislation tends to present itself as original. It is almost never made from scratch. This article makes the hidden process visible. It does so through a study of the near-global spread of environmental impact assessment (EIA) legislation since 1969, using computer-assisted textual similarity analysis to trace what I expected to be identifiable model laws and clear lines of legal inheritance. The search yielded instead a transnational repertoire of legal fragments, repeatedly recombined into new legislative forms across different legal traditions, languages and decades. EIA's legislative spread …

Maine Law Magazine - Issue No. 100, University Of Maine School Of Law

Maine Law Magazine

Features

• Maine Law’s Privacy Program Continues to Innovate
  How Maine Law’s privacy and innovation programs are preparing students for emerging legal challenges.

• New Business & Law Clinic
  Strengthening Maine’s economy one startup at a time.

• Global Experiential Learning
  From the Arctic Circle to U.N. climate negotiations, students engage with environmental law where it happens.

• Rural Access to Justice
  The Rural Practice Clinic’s impact on Maine’s growing justice gap.

• Law & Conservation Efforts
  How Maine Law alumni steward change and safeguard the future through environmental advocacy.

• Supporting Maine’s Vulnerable
  The Refugee & Human Rights Clinic expands access to justice across Maine. …

Early Icu Physiological Subtyping From Time-Series Data: A Comparative Study Of Feature Complexity, Predictive Performance, And Model Interpretability, Rojeena Khadka

College of Graduate Studies: Theses & Dissertations

Intensive Care Unit (ICU) patients do not follow a single uniform physiological pattern. Patients admitted with the same diagnosis show different clinical trajectories over time making standardized classification and treatment approaches insufficient. The increasing availability of large-scale electronic health records in MIMIC-IV makes it possible to investigate such heterogeneity through data-driven approach that captures how physiology evolves during the early phase of ICU admission. This thesis compares two analytical pipelines designed to identify physiological subtypes from the first 48 hours of ICU time series data. This study then assesses how well these subtypes predict in-hospital mortality. The first approach, referred …

Effects Of The Menstrual Cycle Phase On Rpe, And Symptom Characteristics In Pre-Professional Female Soccer Players, Emily Potts

College of Graduate Studies: Theses & Dissertations

Hormonal fluctuations across the distinct phases of the menstrual cycle have been shown to influence physiological and psychological responses to exercise, with some evidence suggesting phase-dependent changes in symptom presentation and ratings of perceived exertion (RPE); however, findings remain inconsistent, and few studies have examined these relationships across an entire competitive season in female soccer players. The purpose of this study was to examine changes in RPE and menstrual symptoms across cycle phases, as well as the relationships between RPE and symptom reporting in pre-professional female soccer players. A total of 22 female soccer players (age 22± 1.85) were recruited …

Disrupting Ableist And Heteronormative Narratives Through The Other-Abled Body In Octavia E. Butler's "The Evening And The Morning And The Night", Morayo Joy Akingbelue

College of Graduate Studies: Theses & Dissertations

Ableist discourse has historically positioned disabled people as ‘unfit,’ resulting in their marginalization within society. This marginalization is not only manifested in terms of their physical performance but sometimes in the way disability intersects with race, gender, and sexuality, reinforcing the construction of disabled individuals as ‘other.’ While prominent feminist and disability scholars have challenged deficit based narratives of disability, Rosemarie Garland-Thomson’s concept of the misfit, Sami Schalk’s Defamiliarization, John Swain and Sally French’s Affirmative Theory, and Moya Bailey and Izetta Autumn Mobley’s A Black Feminist Disability Framework, Black women’s speculative fiction, offers a critical intervention by defamiliarizing dominant narratives …

Revised Microbiology Core Knowledge Objectives For Modern Undergraduate Medical Education, Timothy J. Bauler, Cindy G. Arvidson, Samina Akbar, Dennis N. Arvidson, Margaret E. Bauer, Dwayne M. Baxa, Rebecca J. Greenblatt, Kerstin Honer Zu Bentrup, Yingguang Liu, Inaia Phoenix, Julie A. Kerry

Department of Biomedical and Translational Sciences Faculty Publications

Defining the core content for each scientific discipline in a modern preclinical medical education curriculum is critical to ensure optimal student learning and application of foundational knowledge for clinical practice. Attendees of the Association of Medical School Microbiology and Immunology Chairs (AMSMIC) Educational Strategies Workshop recently highlighted the need for updated medical microbiology learning objectives, given the shift in medical education toward less time for preclinical coursework and more integrated learning. Herein, we describe the process of developing a comprehensive, educator-driven set of knowledge objectives for medical microbiology. These objectives emphasize common pathogens, as well as pathogens associated with severe …

Evaluating Source Material And Seed Propagation Techniques For Spartina Alterniflora To Enhance Salt Marsh Restoration In Coastal Georgia, Maygan Palacios

College of Graduate Studies: Theses & Dissertations

Salt marshes provide critical ecosystem services, including carbon sequestration, flood attenuation, and habitat for diverse aquatic and terrestrial species. Despite their ecological importance, these habitats are increasingly threatened by anthropogenic activities and rising sea levels. To protect and restore salt marshes and their ecosystem services, restoration efforts using living shorelines (LS) have become more common. Along the Eastern and Gulf coasts of the United States, the native grass Spartina alterniflora is commonly used in LS installations for its key role in salt marsh food webs, resilience to abiotic stress, and ability to stabilize and build sediment. Previous studies have documented …

Short Term Trends In Benthic Macroinvertebrate Communities Downstream Of Iron Gate Dam Before And During Klamath Dam Removal, Rosa Cox

Cal Poly Humboldt theses and projects

Dam removals are increasingly being used to restore connectivity and ecological function to rivers degraded by impoundments, yet the short-term ecological impacts of large-scale dam removals remain poorly understood. In 2023-2024, four hydroelectric dams were removed from the Klamath River in Northern California and southern Oregon, mobilizing large volumes of fine sediments stored in reservoirs.  This study evaluated short-term trends in benthic macroinvertebrate (BMI) communities within the first ~90 km downstream of the Klamath dam removal project reach by comparing benthic kick net, invertebrate drift, and juvenile salmonid diet samples before (2022-2023) and during (2024) dam removal at paired mainstem …

Geographic Variation In Proteomic Responses To Ocean Acidification In A Cold-Water Coral (Balanophyllia Elegans), Keana A. Richmond

Cal Poly Humboldt theses and projects

In the face of a rapidly changing climate, assessing organismal responses to future stressors in the context of current, natural exposure to stress could provide key insights to understanding marine ecosystem resilience. I used Balanophyllia elegans, a cold-water, solitary, azooxanthellate coral as a model to better understand how varying oceanographic conditions across its geographic range have shaped its ability to tolerate and potentially adapt to current and future ocean acidification conditions. I collected B. elegans individuals from four sites across 2,500km of their range and subjected them to two pH treatments to investigate site-specific protein expression in response to …

Early Successional Response To Stream Daylighting In Redwood National And State Parks, Orick, California, Rylee Rawson

Cal Poly Humboldt theses and projects

In-channel stream restoration projects can act as both disturbance and recovery mechanisms, disrupting existing conditions to reestablish the hydrologic and ecological processes that sustain stream ecosystems. These interventions initiate successional trajectories in which channel form and biological communities reorganize over time. In Redwood National and State Parks (California, USA), the Redwoods Rising initiative restores buried headwater channels by recontouring legacy logging roads and daylighting streams buried by Humboldt crossings. Using the National Park Service Klamath Network wadable stream monitoring protocol, I evaluated nine restored reaches spanning one to five years post-restoration, alongside old-growth reference reaches and available pre-treatment data. I …

Nourishing Roots: Supporting Indigenous Food Education In School Gardens, Tatiana Marina Patino Madriaga

Cal Poly Humboldt theses and projects

This project asked: How can a school garden at Hoopa Valley Elementary support Indigenous food education, student well-being, and relational learning? To explore this question, I designed and implemented a garden classroom and facilitated hands-on garden and culinary workshops with students.

The garden was planned in September, built in October, and had plants in the ground by November. Over the course of the project, I facilitated four workshops, one Earth Day community event, and weekly garden classes. Approximately 350 students participated in the garden in some capacity, reflecting broad, school-wide engagement.

Methods included participant observation, documentation of student engagement, and …

Ectomycorrhizal Fungi Associated With Pinus Species Of California's Northwestern Coast, Monika Audrey Richardson

Cal Poly Humboldt theses and projects

Ectomycorrhizal (ECM) fungi are vital for increasing host plant uptake of nutrients and stress tolerance within ECM forest ecosystems. The species assemblage of ECM fungi can vary locally in response to numerous biotic and abiotic environmental factors. In California’s northwestern coast the occurrence of three Pinus species, along with a disjunction between populations of Pinus muricata in Mendocino and Humboldt Counties, offer a unique opportunity to investigate the spatial and host effects on pine-associated ECM fungi. Ectomycorrhizal fungal community structure was quantified from host tree roots and sequenced sporocarps occurring at the same sites to create a project specific ITS …

Pretend Play Effects On Autistic Children's Theory Of Mind & Social Skills, Joelle Lok

Cal Poly Humboldt theses and projects

Autistic individuals often struggle with basic social skills due to deficits in Theory of Mind (ToM), perspective taking, reciprocity difficulties, etc. Early interventions that target these skills, specifically metarepresentation skills, could be essential to an individual’s social success and overall well-being. Further, pretend play shares an important relationship with ToM and social skills, due to their shared use of putting oneself in others’ shoes. Thus, a pretend play intervention could be beneficial in not only improving children’s overall play interactions, but also through a domino effect on their ToM and social skills. The directionality of the relationship between pretend play, …