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Articles 15181 - 15210 of 24832
Full-Text Articles in Entire DC Network
Nephrological Factors May Cause Kidney Dysfunction In Patients With Common Variableimmunodeficiency, Gökhan Ayteki̇n, İsmai̇l Baloğlu, Fati̇h Çölkesen, Eray Yildiz, Şevket Arslan, Külti̇gi̇n Türkmen
Nephrological Factors May Cause Kidney Dysfunction In Patients With Common Variableimmunodeficiency, Gökhan Ayteki̇n, İsmai̇l Baloğlu, Fati̇h Çölkesen, Eray Yildiz, Şevket Arslan, Külti̇gi̇n Türkmen
Turkish Journal of Medical Sciences
Background/aim: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, an increased risk of autoimmune disease, malignancy, and chronic inflammation. Proteinuria is one of the most important prognostic factors causing progression in kidney disease. Proteinuria causes tubulotoxicity, activates inflammatory markers that cause fibrosis, and consequently nephropathy progression. The data is scant in the literature regarding the inflammation and nephropathy in CVID. Hence, in the present study, we aimed to investigate the relationship between tubular dysfunction, proteinuria, and inflammation in patients with CVID. Materials and methods: This was a cross-sectional study involving 27 patients with CVID …
Effectiveness Of Mepolizumab Therapy On Symptoms, Asthma Exacerbations, Steroiddependence, And Small Airways In Patients With Severe Eosinophilic Asthma, İnsu Yilmaz, Saki̇ne Nazi̇k Bahçeci̇oğlu, Murat Türk, Nuri̇ Tutar, Gülden Paçaci Çeti̇n, Bahar Arslan
Effectiveness Of Mepolizumab Therapy On Symptoms, Asthma Exacerbations, Steroiddependence, And Small Airways In Patients With Severe Eosinophilic Asthma, İnsu Yilmaz, Saki̇ne Nazi̇k Bahçeci̇oğlu, Murat Türk, Nuri̇ Tutar, Gülden Paçaci Çeti̇n, Bahar Arslan
Turkish Journal of Medical Sciences
Background/aim: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence, and small airways in a real-life cohort of patients with SEA. Materials and methods: We retrospectively analyzed patients with SEA who were receiving fixed-dose mepolizumab. The effects of mepolizumab on clinical, laboratory, functional parameters were evaluated at 12th, 24th, and 52nd …
Tendon Of Flexor Carpi Radialis In Carpal Tunnel: A Radiologic And Cadaveric Study, Burcu Erçakmak Güneş, Alper Vatansever, Mehmet Deni̇z Demi̇ryürek, Kadri̇ye Mi̇ne Ergun, Mehmet Hakan Özsoy
Tendon Of Flexor Carpi Radialis In Carpal Tunnel: A Radiologic And Cadaveric Study, Burcu Erçakmak Güneş, Alper Vatansever, Mehmet Deni̇z Demi̇ryürek, Kadri̇ye Mi̇ne Ergun, Mehmet Hakan Özsoy
Turkish Journal of Medical Sciences
Background/aim: Carpal tunnel is an important anatomical passage that carries the flexor tendons into the hand. As there is still no consensus about its contents among the anatomy textbooks, the main purpose of this study was to identify the relations of the flexor carpi radialis tendon in the carpal tunnel. Materials and methods: This retrospective study was completed in April 2018 at authors' university's hospital. Seventy-four female and 44 male patients' wrists without any pathology were examined by using magnetic resonance images. The series of axial sections where the pisiform exist were evaluated by using T1 sequence and the structures …
Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu
Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu
Turkish Journal of Medical Sciences
Background/aim: The negative impact of oxidative stress on oocytes obtained from in vitro fertilization (IVF) patients is a challenge for the optimization of live birth rates. In this study, it is aimed to investigate whether oxidant/antioxidant parameters have a predictive value in terms of determining the count and quality of oocytes. Materials and methods: Catalase (CAT), glutathione-S-transferase (GST), arylesterase (ARE) enzyme activities, and malondialdehyde (MDA) levels were analysed in cumulus cells of poor responder (n = 28, oocyte count ≤ 4), normo responder (n = 48, 5 ≤ oocyte count ≤ 14), and high responder (n = 26, oocyte count …
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: Volume and T2 relaxation time measurements of the skeletal muscle provide quantitative information. We aimed to evaluate the interobserver reliability and the intraobserver reproducibility of measurements of volumes and T2 relaxation times of the quadriceps femoris and the hamstring muscles. Materials and methods: A cross-sectional reliability study was conducted on ten recreational athletes. The images of the quadriceps and the hamstring muscles of both limbs were obtained using a 3.0 Tesla magnetic resonance imaging (MRI) scanner. Two sports medicine specialists measured muscle volumes from a total of 2560 images and T2 relaxation times from a total of 40 images, …
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …
The Study Of Tau And Phospho Tau Protein Levels In Attention Deficit And Hyperactivity, Hati̇ce Saraçoğlu, Eser Kiliç, Esra Demi̇rci̇
The Study Of Tau And Phospho Tau Protein Levels In Attention Deficit And Hyperactivity, Hati̇ce Saraçoğlu, Eser Kiliç, Esra Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Attention deficit and hyperactivity disorder (ADHD) is a widespread neurodevelopmental disorder that begins in childhood and has negative consequences throughout adult life. The etiology and pathogenesis of ADHD are still unclear. Tau protein is a soluble microtubule-related protein expressed by neurons and localized in the cytoplasm as well as axons. Tau protein provides stability of microtubule in two ways: phosphorylation and isoforms. The excessive phosphorylation of Tau separates the protein from the microtubule, thus making it unstable. In this study, we aimed to investigate whether there is a relationship between serum Tau protein and phospho Tau (p-Tau181) levels and …
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methods: Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid …
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p
The Role Of Anakinra In The Modulation Of Intestinal Cell Apoptosis And Inflammatoryresponse During Ischemia/Reperfusion, Muhammed Kandemi̇r, Necdet Fati̇h Yaşar, Mete Özkurt, Rumeysa Özyurt, Nuri̇ye Ezgi̇ Bektur, Ni̇lüfer Erkasap
The Role Of Anakinra In The Modulation Of Intestinal Cell Apoptosis And Inflammatoryresponse During Ischemia/Reperfusion, Muhammed Kandemi̇r, Necdet Fati̇h Yaşar, Mete Özkurt, Rumeysa Özyurt, Nuri̇ye Ezgi̇ Bektur, Ni̇lüfer Erkasap
Turkish Journal of Medical Sciences
Background/aim: Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, on the I/R induced intestinal injury. Materials and methods: The rat model of intestinal ischemia-reperfusion was induced. Rats were randomized into 4 groups: (group 1) control group, (group 2) I/R group, (group 3 and 4) treatment groups (50 mg/kg and 100 mg/kg, respectively). Gene expressions of caspase-3, TNF-∝, IL-1∝, IL-6, and apoptotic cells in tissue samples were evaluated by PCR and TUNEL methods, respectively. Plasma levels …
Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer
Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer
Turkish Journal of Medical Sciences
Background/aim: Physical exercise is a state of physiological stress that requires adaptation of the organism to physical activity. Glycogen is an important and essential energy source for muscle contraction. Skeletal muscle and liver are two important glycogen stores, and the energy required to maintain exercise in rodents are provided by destruction of this glycogen depot. In this study, the effects of endogenous opioid peptide antagonism at the central nervous system level on tissue glycogen content after exhaustive exercise were investigated. Materials and methods: Rats had intracerebroventricularly (icv) received nonspecific opioid peptide receptor antagonist, naloxone (50 μ/10 μL in saline) and …
Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari
Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received ısole hydrolyzed whey protein (IHWP) at different doses regularly and rats fed with only standard feed. Material & methods: Total 24 rats were randomly divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Second group were given standard feed + daily 0.3 g/kg IHWP and rats in the third group standard feed + 0.5 g/kg IHWP for 12 weeks. Blood samples were collected from …
Possible Antiapoptotic And Neuroprotective Effects Of Magnesium Sulphate On Retina In Apreterm Hypoxic-Ischemic Rat Model, Serhat İmamoğlu, Ebru Yalin İmamoğlu, Serkan Erdenöz, Alev Cumbul, Ünal Uslu, Şami̇l Aktaş, Hüsnü Fahri̇ Ovali
Possible Antiapoptotic And Neuroprotective Effects Of Magnesium Sulphate On Retina In Apreterm Hypoxic-Ischemic Rat Model, Serhat İmamoğlu, Ebru Yalin İmamoğlu, Serkan Erdenöz, Alev Cumbul, Ünal Uslu, Şami̇l Aktaş, Hüsnü Fahri̇ Ovali
Turkish Journal of Medical Sciences
Background/aim: The effects of systemic magnesium sulfate (MgSO4 ) on retina in preterm hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model. Materials and methods: Fifteen, postnatal day (PND) 7 rat pups were divided into 3 groups: 1. Sham-operated group, 2. HI group, and 3. MgSO4 -treated HI group. The second and third groups underwent ischemia followed by exposure to hypoxia for …
Comparison Of The Effect Of Bipolar Coagulation And Fibrillar Structured Oxidizedcellulose On Formation Epidural Fibrosis In Rats, Eyüp Çeti̇n, Burak Eren, Feyza Karagöz Güzey, Azmi̇ Tufan, Abdurrahi̇m Taş, Mustafa Örnek, Bülent Uyanik, Tuğçe Çay
Comparison Of The Effect Of Bipolar Coagulation And Fibrillar Structured Oxidizedcellulose On Formation Epidural Fibrosis In Rats, Eyüp Çeti̇n, Burak Eren, Feyza Karagöz Güzey, Azmi̇ Tufan, Abdurrahi̇m Taş, Mustafa Örnek, Bülent Uyanik, Tuğçe Çay
Turkish Journal of Medical Sciences
Background/aim: Epidural fibrosis (EF) is a common cause of failed back surgery syndrome seen after spinal surgeries. The most frequent reason for the formation of EF is accumulated blood and its products in the operation zone. On the development of EF, the effect of bipolar coagulation and fibrillar oxidized cellulose, which are used frequently to control bleeding, was investigated. Materials and methods: In the study, 45 male Sprague Dawley rats were divided into three groups (control, fibrillar, and bipolar). Lumbar laminectomy was applied to all rats under sterile conditions. In the control group, the epidural area was washed with saline …
The Effect Of Carbon Monoxide Releasing Molecule-2 (Corm-2) On Healing Of Ischemiccolon Anastomosis In Rats, Ali̇ Kemal Kayapinar, Meti̇n Ercan, Kadi̇r Koray Baş, Seda Yamak, Uğur Erçi̇n, Mehmet Aki̇f Türkoğlu, Erdal Bi̇rol Bostanci
The Effect Of Carbon Monoxide Releasing Molecule-2 (Corm-2) On Healing Of Ischemiccolon Anastomosis In Rats, Ali̇ Kemal Kayapinar, Meti̇n Ercan, Kadi̇r Koray Baş, Seda Yamak, Uğur Erçi̇n, Mehmet Aki̇f Türkoğlu, Erdal Bi̇rol Bostanci
Turkish Journal of Medical Sciences
Background/aim: Ischemia on the colon wall negatively affects healing of anastomosis. We were aimed to evaluate the effects of carbon monoxide releasing molecule-2 (CORM-2) on the healing of anastomosis in a rat model of the ischemic colon. Materials and methods: In this prospective study a total of 60 rats were randomly divided into three groups as colon transection and end-to-end anastomosis (Group I), colon transection, and end-to-end anastomosis following the induction of ischemia (Group II), and colon transection and end-to-end anastomosis following the induction of ischemia and treated with daily intraperitoneal administration of CORM-2 (Group III). Each group was also …
Is Cervical Swab An Efficient Method For Developing A New Noninvasive Prenatal Diagnostictest For Numerical And Structural Chromosome Anomalies?, Erkan Yurtcu, Deni̇z Karçaaltincaba, Hasan Hüseyi̇n Kazan, Hali̇s Özdemi̇r, Meral Yi̇rmi̇beş Karaoğuz, Pinar Tokdemi̇r Çaliş, Gülsüm Kayhan, Sezen Günteki̇n Ergün, Ferda Emri̇ye Perçi̇n, Meri̇h Bayram, Mustafa Necmi̇ İlhan, Gamze Bi̇lgi̇li̇ Dedeoğlu, Tuğrul Kaymak, Mehmet Ali̇ Ergün
Is Cervical Swab An Efficient Method For Developing A New Noninvasive Prenatal Diagnostictest For Numerical And Structural Chromosome Anomalies?, Erkan Yurtcu, Deni̇z Karçaaltincaba, Hasan Hüseyi̇n Kazan, Hali̇s Özdemi̇r, Meral Yi̇rmi̇beş Karaoğuz, Pinar Tokdemi̇r Çaliş, Gülsüm Kayhan, Sezen Günteki̇n Ergün, Ferda Emri̇ye Perçi̇n, Meri̇h Bayram, Mustafa Necmi̇ İlhan, Gamze Bi̇lgi̇li̇ Dedeoğlu, Tuğrul Kaymak, Mehmet Ali̇ Ergün
Turkish Journal of Medical Sciences
Background/aim: Prenatal diagnosis is vital to obtain healthy generation for risky pregnancies. There have been several approaches, some of which are routinely applied in clinics to evaluate the possible prenatal deficiencies and/or diseases. In the present study, we aimed to isolate the fetal cells from endocervical samples and try to identify possible anomalies which were proved by Amniocentesis (AS) and chorionic villus sampling (CVS) methods. Materials and methods: Endoservical specimens were collected from 100 pregnant women. Cells were separated in parallel by fluorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) using human leukocyte antigen (HLA) G233 and placental alkaline …
Peripheral Blood Soluble Elastin And Elastase As Auxiliary Diagnostic Indicators Forcoronary Artery Ectasia, Ruifeng Liu, Qianqian Sheng, Siwen Liang, Huiqiang Zhao
Peripheral Blood Soluble Elastin And Elastase As Auxiliary Diagnostic Indicators Forcoronary Artery Ectasia, Ruifeng Liu, Qianqian Sheng, Siwen Liang, Huiqiang Zhao
Turkish Journal of Medical Sciences
Background/aim: Damage to elastin fibres in coronary media might lead to coronary artery ectasia (CAE). This study evaluated whether CAE can be distinguished by detecting circulating soluble elastin (s-elastin), which is a degradation product of elastin fibres, and elastase, which is the main enzyme of elastin fibres. Materials and methods: Fifty-eight patients with CAE, 58 with coronary heart disease (CHD) and 61 with relatively normal coronary arteries, were included. Circulating s-elastin and elastase were measured, and receiver operating characteristic curves were used to demonstrate their respective optimal cut-off values for predicting CAE. Results: The concentrations of s-elastin and elastase were …
Current Community Transmission And Future Perspectives On The Covid-19 Process, Seyhan Türk, Can Türk, Ümi̇t Yavuz Malkan, Eli̇f Sena Temi̇rci̇, Mustafa Çağri Peker, İbrahi̇m Celaletti̇n Haznedaroğlu
Current Community Transmission And Future Perspectives On The Covid-19 Process, Seyhan Türk, Can Türk, Ümi̇t Yavuz Malkan, Eli̇f Sena Temi̇rci̇, Mustafa Çağri Peker, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim: COVID-19 syndrome due to the SARS-CoV-2 virus is a currently challenging situation ongoing worldwide. Since the current pandemic of the SARS-CoV-2 virus is a great concern for everybody in the World, the frequently asked question is how and when the COVID-19 process will be concluded. The aim of this paper is to propose hypotheses in order to answer this essential question. As recently demonstrated, SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome. Our main hypothesis is that the ultimate aim of the SARS-CoV-2 virus is the incorporation to human genome and being an element of the …
Point-Of-Care Ultrasound Assessment Of The Inferior Vena Cava Distensibility Index Inmechanically Ventilated Children In The Operating Room, Riza Di̇nçer Yildizdaş, Özden Özgür Horoz, Ahmet Yöntem, Faruk Eki̇nci̇, Vahi̇de Nagehan Aslan, Demet Lafli Tunay, Murat Türkeün Ilginel
Point-Of-Care Ultrasound Assessment Of The Inferior Vena Cava Distensibility Index Inmechanically Ventilated Children In The Operating Room, Riza Di̇nçer Yildizdaş, Özden Özgür Horoz, Ahmet Yöntem, Faruk Eki̇nci̇, Vahi̇de Nagehan Aslan, Demet Lafli Tunay, Murat Türkeün Ilginel
Turkish Journal of Medical Sciences
Background and aim: Point-of-care ultrasound imaging of the inferior vena cava distensibility index is a potential indicator for determining fluid overload and dehydration in the mechanically ventilated patients. Data on inferior vena cava distensibility index and inferior vena cava distensibility variability are limited in mechanically ventilated pediatric patients. That is why our aim in this study was to measure inferior vena cava distensibility index and to obtain mean values in pediatric patients, ventilated in the operating room before the ambulatory surgical procedure started. Materials and methods: This crosssectional study was performed between February 2019 and February 2020. Ultrasonographic measurements were …
Lycopene Sensitizes The Cervical Cancer Cells To Cisplatin Via Targeting Nuclear Factorkappab (Nf-��B) Pathway, Oktay Hali̇t Aktepe, Taha Koray Şahi̇n, Gürkan Güner, Zafer Arik, Şuayi̇b Yalçin
Lycopene Sensitizes The Cervical Cancer Cells To Cisplatin Via Targeting Nuclear Factorkappab (Nf-��B) Pathway, Oktay Hali̇t Aktepe, Taha Koray Şahi̇n, Gürkan Güner, Zafer Arik, Şuayi̇b Yalçin
Turkish Journal of Medical Sciences
Background/aim: Lycopene is associated with anticancer effects in various tumor types. However, the exact underlying mechanisms of action of lycopene in human cervical cancer remain to be determined. This study aimed to determine anticancer efficacy and mechanism of lycopene in human cervical carcinoma (HeLa) cells. Materials and methods: HeLa cells were treated with cisplatin (1 μM) alone, lycopene (10 μM) alone, and in combination for 72 h. The cell viability of HeLa cells was assessed via MTS assay. Western blot was used to analyze the expression levels of the nuclear factor-kappa B (NF-ΚB), B-cell-associated X protein (Bax), nuclear factor erythroid …
Turkish Reliability And Validity Study Of The Medical Outcomes Study (Mos) Sleep Scale Inpatients With Obstructive Sleep Apnea, Bülent Devri̇m Akçay, Duygu Akçay, Si̇nan Yetki̇n
Turkish Reliability And Validity Study Of The Medical Outcomes Study (Mos) Sleep Scale Inpatients With Obstructive Sleep Apnea, Bülent Devri̇m Akçay, Duygu Akçay, Si̇nan Yetki̇n
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to evaluate the Turkish reliability and validity of the medical outcomes study (MOS) sleep scale in patients who have obstructive sleep apnea. Materials and methods: The data of the study were collected from 120 adult patients with obstructive sleep apnea and from 90 healthy individuals between March 04 and May 31, 2019. Results: The Cronbach's α internal consistency reliability coefficient of the MOS sleep scale was found as 0.82. The test-retest reliability was acceptable (r = 0.76-0.94). Six factors were identified by the factor analysis. These were the same as those in …
Muc1 And Muc5ac Implication In Tunisian Colorectal Cancer Patients, Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui
Muc1 And Muc5ac Implication In Tunisian Colorectal Cancer Patients, Meriam Hazgui, Marwa Weslati, Rahma Boughriba, Donia Ounissi, Dhouha Bacha, Saadia Bouraoui
Turkish Journal of Medical Sciences
Background/aim: Mucins, such as MUC1 and MUC5AC, are known for their protective and moisturizing role in intestinal epithelium. Their expression is tightly controlled given their essential role in normal tissue homeostasis, whereas their deregulation leads to chronic inflammation, and even cancer. This study aimed to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis. Materials and methods: A retrospective study of 202 patients who underwent colorectal cancer (CRC) surgery was conducted. The expression of MUC1 and MUC5AC was investigated by immunohistochemistry and reverse-transcription polymerase chain reaction (RT-PCR). Statistical analysis of mucin expression pattern, as well …
Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu
Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials and methods: We analyzed all patients registered in the HURBİO database who received at least 1 dose of tofacitinib. Patients who received at least one dose were included in retention analysis; patients with at least 1 control visit were included in efficacy and safety analysis. Factors predicting good response at the last follow-up visit were analyzed by logistic regression analysis. Drug retention rates were calculated using the Kaplan-Meier method and predictors of drug retention were determined by Cox proportional hazard model. …
Exenatide Improves Cardiovascular Risk Factors In Obese Patients With Type 2 Diabetesmellitus: A Prospective Study, Derya Köseoğlu, Sali̇h Süha Koparal, Özden Özdemi̇r Başer, Di̇lek Berker
Exenatide Improves Cardiovascular Risk Factors In Obese Patients With Type 2 Diabetesmellitus: A Prospective Study, Derya Köseoğlu, Sali̇h Süha Koparal, Özden Özdemi̇r Başer, Di̇lek Berker
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate the effects of a 6-month treatment regimen with exenatide on the lipid profile, high-sensitivity C-reactive protein (hsCRP), carotid intima media thickness (CIMT), visceral adiposity, and nonalcoholic fatty liver disease (NAFLD), all of which are important cardiovascular risk factors. Materials and methods: This study included 45 obese patients with type 2 diabetes mellitus (T2DM). Baseline clinical findings, laboratory parameters, and ultrasonography findings were recorded. An exenatide recipe was given twice daily to the patients and, after 6 months of therapy, the same variables were compared. The compared parameters were lipid profiles, hsCRP, …
The Evaluation Of Intracellular Energy Metabolism In Prediabetic Patients And Patientsnewly Diagnosed With Type 2 Diabetes Mellitus, Erkan Dulkadi̇roğlu, Hüseyi̇n Özden, Hüseyi̇n Demi̇rci̇
The Evaluation Of Intracellular Energy Metabolism In Prediabetic Patients And Patientsnewly Diagnosed With Type 2 Diabetes Mellitus, Erkan Dulkadi̇roğlu, Hüseyi̇n Özden, Hüseyi̇n Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Increased susceptibility to infections is a serious problem in diabetics. Impairment in the energy metabolism of the immune system is the main source of the problem. Early diagnosis of the impairment in energy metabolism is crucial. Our study aimed to investigate the energy metabolism in leukocytes in patient groups such as prediabetics and patients newly diagnosed with type 2 diabetes mellitus. Materials and methods: Our study included 21 newly diagnosed type 2 diabetic patients (NDDP), 30 prediabetic patients, and 22 adult volunteers. 75 g oral glucose tolerance test (OGTT) was applied to all patients included in the study. Blood …
Clinicopathological Characteristics And Mutational Profile Of Kras And Nras Intunisian Patients With Sporadic Colorectal Cancer, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui
Clinicopathological Characteristics And Mutational Profile Of Kras And Nras Intunisian Patients With Sporadic Colorectal Cancer, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Meriam Hazgui, Saadia Bouraoui
Turkish Journal of Medical Sciences
Background/aim: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia due to its increasing rate of incidence. KRAS and NRAS mutations have become a pivotal part of CRC diagnosis, given their association to treatment resistance with antiepidermal growth factor receptor (EGFR) monoclonal antibodies. In this study, we aimed to screen for mutations in KRAS and NRAS genes in Tunisian patients with CRC and explore their correlations with clinicopathological features. Materials and methods: AmoyDx KRAS and NRAS mutation real-time PCR kits were used to screen for mutations in KRAS (exon 2) and NRAS (exons 2, 3, and …
Ige-Mediated Food Allergy Throughout Life, Ebru Çelebi̇oğlu, Ayşegül Akarsu, Ümi̇t Murat Şahi̇ner
Ige-Mediated Food Allergy Throughout Life, Ebru Çelebi̇oğlu, Ayşegül Akarsu, Ümi̇t Murat Şahi̇ner
Turkish Journal of Medical Sciences
No abstract provided.
Can Urinary Biomarkers Predict Acute Kidney Injury In Newborns With Critical Congenitalheart Disease?, Özgün Uygur, Özge Altun Köroğlu, Reşi̇t Ertürk Levent, Eser Sözmen, Firat Ergi̇n, Yüksel Atay, Mehmet Yalaz, Mete Akisü, Ni̇lgün Kültürsay
Can Urinary Biomarkers Predict Acute Kidney Injury In Newborns With Critical Congenitalheart Disease?, Özgün Uygur, Özge Altun Köroğlu, Reşi̇t Ertürk Levent, Eser Sözmen, Firat Ergi̇n, Yüksel Atay, Mehmet Yalaz, Mete Akisü, Ni̇lgün Kültürsay
Turkish Journal of Medical Sciences
Background/aim: Congenital heart disease (CHD) is the most common congenital malformation group and is the leading cause of newborn mortality in developed countries. Most of the infants with CHD develop preoperative or postoperative acute kidney injury (AKI). Acute kidney injury may develop before the serum creatinine rise and oliguria. Urinary biomarkers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, and cystatin C may predict AKI in patients with critical CHD (CCHD) before the serum creatinine rise. In this study, we aimed to determine the AKI incidence among newborn patients with CCHD and investigate the predictivity of …
The Importance Of Histological Patterns On Pd-L1 Staining Heterogeneity: Should Weuse Pattern-Based Approach For Selecting Tumor Samples For Pd-L1 Testing In Lungadenocarcinomas?, Pinar Bulutay, Pinar Firat, Emi̇ne Handan Zeren, Suat Erus, Serhan Tanju, Mustafa Şükrü Di̇lege
The Importance Of Histological Patterns On Pd-L1 Staining Heterogeneity: Should Weuse Pattern-Based Approach For Selecting Tumor Samples For Pd-L1 Testing In Lungadenocarcinomas?, Pinar Bulutay, Pinar Firat, Emi̇ne Handan Zeren, Suat Erus, Serhan Tanju, Mustafa Şükrü Di̇lege
Turkish Journal of Medical Sciences
Background/aim: Programmed death ligand-1 (PD-L1) is a predictive marker for immunotherapeutic agents. However, heterogeneous staining of PD-L1 can cause false-negative results. The aim of this study is to evaluate the importance of histological patterns on PD-L1 staining heterogeneity in lung adenocarcinomas (LAC). Materials and methods: PD-L1 immunohistochemistry (IHC) stain was performed to two different tissue cores of 128 LAC cases, and cut-off values are given for grouping the cases according to the percentage of staining (1%-10%, 11%-49%, 50%-100%). Staining rates between cores were compared and analyzed by their histological patterns. Also, the relation of the PD-L1 expression with the clinicopathological …
A Novel Dimensionality Reduction Approach To Improve Microarray Data Classification, Mohammed Hasim, Ismail El Mouden, Mounir Ouzir, Hicham Moutachaouik, Mustapha Hain
A Novel Dimensionality Reduction Approach To Improve Microarray Data Classification, Mohammed Hasim, Ismail El Mouden, Mounir Ouzir, Hicham Moutachaouik, Mustapha Hain
Department of Medicine Faculty Publications
Cancer tumor prediction and diagnosis at an early stage has become a necessity in cancer research, as it provides an increase in the treatment success chances. Recently, DNA microarray technology became a powerful tool for cancer identification, that can analyze the expression level of a different and huge number of genes simultaneously. In microarray data, the large genes number versus a few records may affect the prediction performance. In order to handle this "curse of dimensionality” constraint of microarray dataset while improving the cancer identification performance, a dimensional reduction phase is necessary. In this paper, we proposed a framework that …