Digital Commons Network^™

Changes In The Serum, Liver, And Renal Cortical Lipids And Electrolytesin Rabbits With Cisplatin-Induced Nephrotoxicity, Abdelgayoum Ahmed Abdel-Gayoum, Mohamed Hamza Sulaiman Ahmida

Turkish Journal of Medical Sciences

Background/aim: Cisplatin is an anticancer drug that can induce nephrotoxicity. Its toxicity is associated with dyslipidemia and disturbed electrolyte balance. In the present study we investigated the changes in serum lipid profile and electrolyte levels and their contents in kidney and liver tissues of rabbits treated with cisplatin. Materials and methods: Twenty-eight adult male New Zealand White rabbits were used in the experiment. Animals of groups C, P1, and P2 were injected with saline, cisplatin (4.0 mg/kg bw), and cisplatin (6.5 mg/kg bw), respectively, and killed 3 days after the injections. Animals of group R were given cisplatin (6.5 mg/kg …

Antiinflammatory And Antioxidant Effects Of Gemcitabinein Collagen-Induced Arthritis Model, Adi̇le Ferda Dağli, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Meti̇n Özgen, Kazi̇m Şahi̇n, Süleyman Serdar Koca

Turkish Journal of Medical Sciences

Background/aim: Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). Materials and methods: Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into albino Wistar rats. Doses of 5 and 20 mg/kg GEM were administered twice a week after the 14th day, which marked the onset the arthritis. Serum IL-17, TNF-α, malondialdehyde, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels and tissue heme oxygenase-1 (HO-1) and nuclear factor …

Risk Factors For Recurrent Central Line-Associated Bloodstream Infections In Apediatric Intensive Care Unit, Rana İşgüder, İlker Devri̇m, Gökhan Ceylan, Ahu Kara, Gamze Gülfi̇dan, Hasan Ağin

Turkish Journal of Medical Sciences

Background/aim: It is recommended that a central venous catheter (CVC) be removed if central line-associated bloodstream infection (CLABSI) has been diagnosed. The objective of this retrospective study was to evaluate the risk factors for recurrent CLABSI in reinserted catheters in a pediatric intensive care unit. Materials and methods: Patients with recurrent and nonrecurrent CLABSI were compared in terms of the catheter exchange interval, the interval between negative blood culture and reinsertion of the CVC, and the pre-/reinsertion treatment duration. Results: Thirty-one patients with initial CLABSI had reinserted CVCs, and 12 (38.7%) of these patients were diagnosed with recurrent CLABSI. In …

The Prevalence Of Abdominal Obesity Is Remarkable For Underweightand Normal Weight Adolescent Girls, Ni̇lüfer Tek, Nevi̇n Şanlier, Duygu Türközü

Turkish Journal of Medical Sciences

Background/aim: Obesity is a global public health challenge. This study was carried out in order to determine the prevalence of obesity and abdominal obesity in Turkish adolescent girls. Materials and methods: A cross-sectional study was conducted in a total of 1111 adolescent girls aged 12?18 years. The subjects were classified into four groups: underweight, normal, overweight, and obese. Abdominal obesity was defined according to waist circumference (WC) $\geq$ 90th percentile for Turkish adolescent population references (12-17 years) and waist-to-height ratio (WHtR) $\geq$ 0.5. Results: The prevalence of underweight was 17.4%, normal weight 68.5%, overweight 12.1%, and obese 2.0%. A total …

Application Of Hemoperfusion In Severe Acute Organophosphorus Pesticide Poisoning, Zhenhe Li, Guixia Wang, Guodong Zhen, Yuliang Zhang, Jiaqiang Liu, Shanmei Liu

Turkish Journal of Medical Sciences

Background/aim: The aim of this research is to investigate the clinical efficacy of hemoperfusion in the treatment of severe acute organophosphorus pesticide poisoning (AOPP). Materials and methods: Patients meeting the inclusion criteria were divided into Groups 1 and 2 according to whether hemoperfusion was applied or not. Group 2 was observed as the control group. Conventional therapy for AOPP was given to Groups 1 and 2. Besides conventional treatment, patients in Group 1 were also treated with hemoperfusion therapy. Cholinesterase activity and blood glucose concentration were tested before hemoperfusion and for the first 3 days afterwards. The recovery time of …

Evaluation Of The General Characteristics Of Patients Aged 85 Years And Above Admitted To A University Hospital Emergency Department, Ahmet Demi̇rcan, Şahender Gülbi̇n Aygencel Bikmaz, Gülteki̇n Kadi, Ayfer Keleş, Fi̇kret Bi̇ldi̇k, Begüm Öktem, Onur Çakmak

Turkish Journal of Medical Sciences

Background/aim: The number of elderly people ($\ge$65 years old) is increasing both in Turkey and internationally due to improved living conditions and decreased mortality rates. Knowing the characteristics of elderly patients admitted to emergency departments can provide guidance for diagnosis and treatment approaches. In this study, we analyzed the characteristics of very old patients (4$\ge$85 years old) admitted to the emergency department and put together data for use in forward planning in healthcare services.Materials and methods: This retrospective study included all patients aged $\ge$85 years admitted to the Adult Emergency Department of Gazi University Medical Faculty Hospital between 01.01.2014 and …

Effect Of Treatment Of Iron Deficiency Anemia Onhemoglobin A1c In Type 2 Diabetic Patients, Ensieh Nasli-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodsi Ghasemabadi, Rezvan Razmandeh

Turkish Journal of Medical Sciences

Background/aim: Iron deficiency anemia (IDA) affects hemoglobin A1c (HbA1c) levels. This study aimed to evaluate the effect of treatment of iron deficiency anemia on hemoglobin A1c in type 2 diabetic patients.Materials and methods: Ninety type 2 diabetes mellitus (T2DM) patients with IDA were included in a randomized, placebo-controlled, single-blind clinical trial. The intervention group (n = 45) received 200 mg/day oral iron for 3 months and the control group (n = 45) received an oral placebo for the same period. Fasting blood sugar, complete blood count, and HbA1c were measured for all subjects at the beginning and the end of …

Combined Oral Supplementation Of Chromium Picolinate, Docosahexaenoic Acid, And Boron Enhances Neuroprotection In Rats Fed A High-Fat Diet, Cemal Orhan, Nurhan Şahi̇n, Zeynep Tuzcu, James R. Komorowski, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the …

An Examination Of Healthcare-Associated Infections In Elderly Patients, Serap İskender, Gürdal Yilmaz, İftahar Köksal

Turkish Journal of Medical Sciences

Background/aim: Healthcare-associated infections (HCAIs) are increasing due to the growing numbers of elderly people requiring long-term care and immunosuppressive therapies. The purpose of this study was to examine HCAIs occurring in elderly inpatients in our hospital.Materials and methods: This study prospectively investigated HCAIs developing in all patients hospitalized over a 1-year period. Diagnosis was based on Centers for Disease Control criteria. The results were subjected to statistical analysis between patients aged over and under 65.Results: A total of 24,692 patients were evaluated and 894 HCAIs were identified. Of these infections, 214 were seen in patients aged 65 or over. The …

Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu

Turkish Journal of Medical Sciences

Background/aim: The DAWN2 (Diabetes Attitudes, Wishes, and Needs) study was conducted in order to ascertain the wishes, needs, and attitudes of diabetes patients, their relatives, and healthcare professionals. The study was conducted across 17 countries, including Turkey, and its objective was to introduce policies that could successfully meet these requirements. In this article, the needs, wishes, and attitudes of diabetes patients and their relatives in Turkey are compared with those from other countries. Materials and methods: Eighty patients with type 1 diabetes, 426 patients with type 2 diabetes, and 126 relatives of patients with diabetes were included in the study. …

An 8-Week Thoracic Spine Stabilization Exercise Program Improves Postural Back Pain,Spine Alignment, Postural Sway, And Core Endurance In University Students:A Randomized Controlled Study, Şeyda Toprak Çelenay, Derya Özer Kaya

Turkish Journal of Medical Sciences

Background/aim: To investigate the effects of an 8-week thoracic stabilization exercise program on back pain, spinal alignment, postural sway, and core endurance in university students. Materials and methods: University students were randomly allocated into exercise (n: 28) and control (n: 25) groups. The exercise program was carried out 3 days a week for 8 weeks. Postural pain, spinal alignment, postural sway, and core endurance were assessed via visual analogue scale, Spinal Mouse, Biodex Balance System, and McGill?s trunk muscle endurance tests at the baseline and after 8 weeks of training. Results: Differences were observed for postural pain, thoracic and lumbar …

Molecular Characteristics And Antibiotic Resistance Of Acinetobacter Baumanniibeta-Lactamase-Producing Isolates, A Predominance Of Intrinsic Blaoxa-51, And Detection Oftem And Ctx-M Genes, Amir Ibrahimagic, Farah Kamberovic, Selma Uzunovic, Branka Bedenic, Emina Idrizovic

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine the molecular characteristics and antibiotic resistance of 13 (10 inpatient and three outpatient) Acinetobacter baumannii beta-lactamase-producing isolates collected in Bosnia and Herzegovina between December 2009 and May 2010. Materials and methods: Susceptibility testing was performed by disk diffusion and broth microdilution methods. The modified Hodge and combined disk test with EDTA/phenylboronic acid was used to screen for carbapenemase production. Production of extended spectrum beta-lactamases (ESBLs) was determined by double-disk synergy test. PCR was used to detect blaESBL/blacarb genes. Results: Ten (22.2%) inpatient and three (13.6%) outpatient isolates produced beta-lactamases, ESBLs, or …

Maternal Inflammation At Mid-Gestation In Pregnant Rats Impairs Fetal Muscle Growth And Development At Term, C. N. Cadaret, K. A. Beede, E. M. Merrick, T. L. Barnes, J. D. Loy, D. T. Yates

School of Veterinary and Biomedical Sciences: Faculty Publications

Intrauterine growth restriction (IUGR) is a leading cause of perinatal morbidity and mortality. Low birth weight resulting from preterm birth and/or IUGR is an underlying factor in 60–80% of perinatal death worldwide, and is particularly common in developing countries (UNICEF, 2008). Furthermore, studies have linked IUGR and the associated fetal malnutrition to increased incidence of metabolic syndrome in adult life (Barker et al., 1993; Godfrey and Barker, 2000). The “thrifty phenotype hypothesis” developed by David Barker (Hales et al., 1991) states that IUGR-associated fetal malnutrition forces the fetus to spare nutrients by altering tissue-specific metabolism in order to survive. In …

Sports Cardiology: Core Curriculum For Providing Cardiovascular Care To Competitive Athletes And Highly Active People., Aaron L. Baggish Md, Robert W. Battle Md, James G. Beckerman Md, Alfred A. Bove Md, Phd, Rachel J. Lampert Md, Benjamin D. Levine Md, Mark S. Link Md, Matthew W. Martinez Md, Silvana M. Molossi Md, Phd, Jack Salerno Md, Meagan M. Wasfy Md, Rory B. Weiner Md, Michael S. Emery Md

Department of Medicine

The last few decades have seen substantial growth in the populations of competitive athletes and highly active people (CAHAP). Although vigorous physical exercise is an effective way to reduce the risk of cardiovascular (CV) disease, CAHAP remain susceptible to inherited and acquired CV disease, and may be most at risk for adverse CV outcomes during intense physical activity. Traditionally, multidisciplinary teams comprising athletic trainers, physical therapists, primary care sports medicine physicians, and orthopedic surgeons have provided clinical care for CAHAP. However, there is increasing recognition that a care team including qualified CV specialists optimizes care delivery for CAHAP. In recognition …

Evaluation Of Major And Minor Lower Extremity Amputation In Diabetic Foot Patients, Firat Ozan, Kaan Gürbüz, İlhami̇ Çeli̇k, Zehra Beştepe Dursun, Erdal Uzun

Turkish Journal of Medical Sciences

Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. On clinical evaluation, the type of surgery performed, smoking history, comorbidities, duration of diabetes mellitus (DM) diagnosis, duration of DFU presence, peripheral neuropathy, peripheral arterial disease, results of deep tissue culture, length of hospitalization, and blood …

Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z

Turkish Journal of Medical Sciences

Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay. DNA was extracted from fecal samples of about 200 mg using the QIAamp Fast DNA Stool Mini Kit (QIAGEN, Hilden, …

Relation Of Unsupported And Unsupervised Exercise With Anthropometric And Biochemical Indices Among Type 2 Diabetic Patients, Prince Chikwere, Kwabena Nsiah, Marina Tandoh

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes is a lifestyle-related condition. Lifestyle modification in the management of type 2 diabetes incorporates exercise. The aim of this study was to find out how unsupported and unsupervised exercise relates to anthropometric indices and biochemical indices in type 2 diabetes patients. Materials and methods: In the cross-sectional study, a structured questionnaire was used to access data on the exercise history of patients. Subjects were classified according to exercise intensity. The dietary intake of patients was obtained by 24-h recall. Standard measurements were taken of waist circumference and blood pressure. Blood samples were also collected to measure …

Association Of B7-H4 Gene Polymorphisms In Urothelial Bladder Cancer, Asuman Özgöz, Murat Şamli, Deni̇z Di̇nçel, Ahmet Şahi̇n, Ümi̇t İnce, Yeşi̇m Sağlican, Faruk Balci, Hale Şamli

Turkish Journal of Medical Sciences

Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.

Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç

Turkish Journal of Medical Sciences

Background/aim: Central line-associated bloodstream infections (CLABSIs) are associated with substantial morbidity and mortality and the infection rates vary in a wide range (high: 62.5%; low: 20%) in developing countries. We aimed to investigate the characteristics and the risk factors for mortality in patients with CLABSIs in intensive care units (ICUs) and provide the relevant data. Materials and methods: The electronic medical records database and file records obtained through active surveillance by an infection control committee of a hospital were screened to identify patients with CLABSIs hospitalized from January 2008 through July 2013. Results: A total of 166 CLABSI episodes in …

Modifications Of Mice Gut Microflora Following Oral Consumption Oflactobacillus Acidophilus And Bifidobacterium Bifidum Probiotics, Hossein Khavari-Daneshvar, Maryam Mosavi, Hamid Khodayari, Ebrahim Rahimi, Peyman Ranji, Amir Hossein Mohseni, Reyhaneh Mahmudian, Farzad Shidfar, Shahram Agah, Ali Mohammad Alizadeh

Turkish Journal of Medical Sciences

Background/aim: Thirty male BALB/c mice were equally divided into three groups: control, L. acidophilus, and B. bifidum for the assessment of the probiotics' stability in the gut microflora. Materials and methods: First, the gut microflora of the mice was checked every 3 days (days 3, 6, 9, and 12) without probiotic consumption, and then the mice were daily given orally 1.5 g of probiotics in 30 cc of drinking water. The consumption of probiotics was then stopped for recovery and then the consumption continued for 5 months. Results: On day 9 after the consumption of the probiotics, L. acidophilus and …

Antioxidants Status In Type 2 Diabetic Patients In Morocco, Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi

Turkish Journal of Medical Sciences

Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se). Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly …

Possible Triggering Factors And Comorbidities In Newlydiagnosed Autoimmune Bullous Diseases, Sevgi̇ Akarsu, Özlem Özbağçivan, Necla Dolaş, Şebnem Aktan

Turkish Journal of Medical Sciences

Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods: In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, …

Effects Of Artcure Diffusional Patch Application On Pain And Functional Status In Lumbar Disc Herniation Patients: A Prospective Randomized Controlled Study, Mahmut Uğurlu, Mehmet Atif Erol Akseki̇li̇, Berat Meryem Alkan, Hali̇l Kara, Ceyhun Çağlar

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to assess the efficacy of the Artcure Diffusional Patch, which contains a mixture of 6 herbal oils (oleum thymi, oleum limonis, oleum nigra, oleum rosmarini, oleum chamomilla, oleum lauriexpressum) and has a hypoosmolar lipid structure, in the conservative treatment of lumbar disc herniation patients and to show the advantages and/or possibility of using this as an alternative method to surgery. Materials and methods: Of the 120 patients enrolled, 79 clinically diagnosed patients were included in the study. Clinical evaluations were performed on patients who had findings of protrusion or extrusion in their magnetic …

A Comparison Of Culture And Pcr Methods For Identifying Propionibacterium Acnes In Lesions Isolated From Patients With Acne, Negin Naghdi, Masood Ghane

Turkish Journal of Medical Sciences

Background/aim: One of the factors that affect the occurrence of acne is the presence of Propionibacterium acnes. The present study was conducted to compare the culture and polymerase chain reaction (PCR) methods for identifying P. acnes in lesions isolated from patients with acne. Materials and methods: To examine the presence of P. acnes, 70 samples of acne lesions were collected. Microbial culture and the PCR molecular technique were used to identify P. acnes. Results: Of the total of 70 samples, 14 cases (20%) were identified as P. acnes positive using microbial culture and 58 cases (82.85%) using PCR. The results …

Investigation Of The Behavioral And Neurochemical Effects Of Monosodium Glutamate On Neonatal Rats, Ayşen Çetin Kardeşler, Eyup Başkale

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period. Materials and methods: In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method. Results: Considering the …

Evaluation Of Risk Factors For The Recurrence Of Colorectal Polyps And Colorectal Cancer, Öztürk Ateş, Bülent Si̇vri̇, Saadetti̇n Kiliçkap

Turkish Journal of Medical Sciences

Background/aim: Colorectal adenomatous polyps are precursors of colorectal cancer (CRC), which can be prevented with surveillance colonoscopy. This study aimed to assess risk factors for the recurrence of colorectal polyps and CRC following polypectomy. Materials and methods: In this single-center trial, a total of 510 patients who applied to the endoscopy unit of Hacettepe University Hospital for various reasons and who were diagnosed with at least one colorectal adenomatous polyp between 2000 and 2010 were retrospectively analyzed. Patients with colorectal adenomatous polyps or CRC recurrences were examined in terms of clinical and histological risk factors. Results: A total of 190 …

Effects Of Valproic Acid On Sympathetic Activity And Left Ventricularmyocardial Remodelling In Rats During Pressure Overload, Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu

Turkish Journal of Medical Sciences

Background/aim: Pressure overload induces cardiac remodelling and results in heart failure. Enhanced sympathetic outflow participates in the development of cardiac remodelling for the duration of pressure overload as an independent factor. Valproic acid has recently been shown to reduce neuronal injury and have antiinflammatory and antiapoptotic effects as a histone deacetylase inhibitor. We speculate that the drug plays a specific role in alleviating cardiac remodelling by inhibiting sympathetic activity. Materials and methods: Surgery of partial abdominal aortic constriction was performed on male Sprague-Dawley rats. After 4 weeks, animal models of pressure overload were validated and then valproic acid (300 mg/kg) …

Do Preoperative Oral Carbohydrates Improve Postoperative Outcomesin Patients Undergoing Coronary Artery Bypass Grafts?, Ömer Faruk Şavluk, Mehmet Ali̇ Kuşcu, Füsun Güzelmeri̇ç, Mustafa Emre Gürcü, Atakan Erkilinç, Deni̇z Çevi̇rme, Hali̇de Oğuş, Tuncer Koçak

Turkish Journal of Medical Sciences

Background/aim: The aim of this prospective study was to determine whether the preoperative oral intake of carbohydrate-rich drinks by patients undergoing a coronary artery bypass graft attenuates postoperative insulin requirements, improves postoperative patient discomfort, provides inotropic support, shortens the length of the ICU stay, and shortens the duration of postoperative mechanical ventilation. Materials and methods: This randomized prospective clinical study included 152 patients with coronary artery disease who were divided into 4 groups. Carbohydrates were administered to 3 groups at different hours and doses before operation. The fourth group had an 8-h preoperative fasting period. The inotropic and vasopressor requirements, …

Associations Of Apgar Score And Size At Birth With Lipoprotein Subclasses In Juvenile Obesity, Osama Bekhet, Jelena Vekic, Aleksandra Zeljkovic, Dusan Paripovic, Tamara Gojkovic, Jelena Janac, Vesna Spasojevic-Kalimanovska, Amira Peco-Antic, Gordana Milosevski-Lomic, Zorana Jelic-Ivanovic, Aleksandra Stefanovic

Turkish Journal of Medical Sciences

Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions.Materials and methods: We included 42 obese children, aged 14.2 ± 2.1 years. LDL and HDL subfractions were separated by gradient …

Telomerase Reverse Transcriptase In Atherosclerosis, Hua Qing

Theses and Dissertations--Pharmacology and Nutritional Sciences

Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase and the limiting factor for the enzyme activity. The expression of TERT and telomerase activity is increased in atherosclerotic plaques. However, the role of TERT dysregulation during atherosclerosis formation remains unknown.

The work herein first identified a multi-tiered regulation of TERT expression in smooth muscle cells (SMC) through histone deacetylase (HDAC) inhibition. HDAC inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein abundance through enhanced degradation, which decreases telomerase activity and induces senescence. Furthermore, during vascular remodeling in vivo, TERT protein …