Digital Commons Network^™

Stool Microbiome, Ph And Short/Branched Chain Fatty Acids In Infants Receiving Extensively Hydrolyzed Formula, Amino Acid Formula, Or Human Milk Through Two Months Of Age, Car Reen Kok, Bradford Brabec, Maciej Chichlowski, Cheryl L. Harris, Nancy Moore, Jennifer L. Wampler, Jon Vanderhoof, Devin Rose, Robert Hutkins

Food for Health: Publications

CRISPR–Cas is an anti-viral mechanism of prokaryotes that has been widely adopted for genome editing. To make CRISPR–Cas genome editing more controllable and safer to use, anti-CRISPR proteins have been recently exploited to prevent excessive/prolonged Cas nuclease cleavage. Anti-CRISPR (Acr) proteins are encoded by (pro)phages/(pro)viruses, and have the ability to inhibit their host’s CRISPR–Cas systems. We have built an online database AcrDB (http://bcb.unl.edu/AcrDB) by scanning ∼19 000 genomes of prokaryotes and viruses with AcrFinder, a recently developed AcrAca (Acr-associated regulator) operon prediction program. Proteins in Acr-Aca operons were further processed by two machine learning-based programs (AcRanker and PaCRISPR) to obtain …

Quality And Clinical Care Development In Spine Surgery-Connecting The Dots: An Expanded Clinical Narrative., Sarah Hopkins, Polly Brune, Jens R Chapman, Marc Horton, Rod J Oskouian, Akshal Patel, Marc D Moisi

Articles, Abstracts, and Reports

Our health care system is an evidenced-based quality-centric environment. Pursuit of quality is a process that encompasses knowledge development and care advancements through collaboration and expertise. Depicted here is the foundational knowledge, process, and contributions that hallmark successful clinical quality programs. Beginning with methodology, followed by process and form, we create the foundational knowledge and exemplars demonstrating framework and continuum of process in pursuit and attainment of successful clinical quality and care development for patients. Although our protocol has been devised for complex spine care, this could be implemented across all health care specialties to provide individualized and high-quality care …

Alkalinizing Agents: A Review Of Prescription, Over-The-Counter, And Medical Food Supplements., Karen L. Stern, Noah Canvasser, Michael Borofsky, Vanessa M. Gleason, Guido Kamphuis, Marawan M. El Tayeb, Ryan Hsi, Kymora B. Scotland

Jefferson Hospital Staff Papers and Presentations

Introduction

Kidney stones affect 1 in every 11 people in the United States each year. There is a significant high recurrence rate without a stone prevention protocol. Alkali citrate is beneficial in decreasing stone recurrence, but due to the cost and gastrointestinal side effects there is a low adherence rate. This study aims to serve as a review of some of the most commonly used alkalizing over‐ the‐ counter supplements that are advertised to prevent and treat kidney stones.

Methods

Data was gathered by a comprehensive online literature search and company inquiries for kidney stone prevention supplements. An additional informal …

Prophylaxis Of Food Allergen Sensitivity, Dustin Gottfeld

Physician Assistant Studies | Student Authored Articles

Food allergies can have a severe and drastic effect on a person’s lifestyle, while prevention of allergic disease can help to ensure others do not have to live with this burden. There are a variety of differing hypotheses that offer explanations for the early development of food allergies, particularly peanut allergies. Two of the foremost hypotheses are the Hygiene Hypothesis and the Dual-Allergen Hypothesis. The Hygiene Hypothesis claims that the diversity of a child’s microbiota creates a beneficial balance of microorganisms which can help prevent the development of allergic disease. Alternatively, the Dual-Allergen Hypothesis states that early environmental exposure to …

Larval Performance Of A Major Forest Pest On Novel Hosts And The Effect Of Stressors, Donnie Lee Peterson, Don Cipollini

Biological Sciences Faculty Publications

Novel hosts lacking a coevolutionary history with herbivores can often support improved larval performance over historic hosts; e.g., emerald ash borer [Agrilus planipennis (Fairmaire) Coleoptera: Buprestidae] on North American ash (Fraxinus spp.) trees. Whether trees are novel or ancestral, stress on plants increases emerald ash borer preference and performance. White fringetree [Chionanthus virginicus (L.) Lamiales: Oleaceae] and olive [Olea europaea (L.) Lamiales: Oleaceae] are closely related non-ash hosts that support development of emerald ash borer to adulthood, but their relative suitability as hosts and the impact of plant stress on larval success has not been well …

การเปรียบเทียบองค์ประกอบของร่างกายในผู้ป่วยโรคอ้วนหลังเข้ารับการผ่าตัดกระเพาะเพื่อลดน้ำหนักกับองค์ประกอบของร่างกายในผู้ที่ไม่เคยได้รับการผ่าตัดกระเพาะเพื่อลดน้ำหนักมาก่อน, ศิรินรัตน์ ตั้งจิตตรง

Chulalongkorn University Theses and Dissertations (Chula ETD)

วัตถุประสงค์ เพื่อศึกษาการเปลี่ยนแปลงองค์ประกอบของร่างกายในผู้ป่วยโรคอ้วนหลังการผ่าตัดกระเพาะเพื่อลดน้ำหนัก ที่ระยะเวลา 12 เดือน และเปรียบเทียบกับกลุ่มผู้ที่ไม่เคยได้รับการผ่าตัดกระเพาะเพื่อลดน้ำหนักมาก่อน ที่มี อายุ เพศ และค่าดัชนีมวลกายใกล้เคียงกัน วิธีการวิจัย เป็นการวิจัยโดยการสังเกตเชิงวิเคราะห์โดยใช้ข้อมูลผู้ป่วยโรคอ้วนที่ได้รับการผ่าตัดกระเพาะเพื่อลดน้ำหนักด้วยวิธี Laparoscopic Roux-en-Y gastric bypass(LRYGB) หรือ Laparoscopic sleeve gastrectomy(LSG) ในโรงพยาบาลจุฬาลงกรณ์ ช่วงปี พ.ศ.2558-2562 ที่หลังผ่าตัดที่ 12 เดือน มีค่าดัชนีมวลกาย น้อยกว่า 30 กิโลกรัม/เมตร2 กลุ่มควบคุมคือกลุ่มผู้ที่ไม่เคยได้รับการผ่าตัดกระเพาะที่มี อายุ เพศ และค่าดัชนีมวลกายใกล้เคียงกัน และไม่มีโรคประจำตัว วิเคราะห์องค์ประกอบของร่างกายด้วยเครื่อง Inbody 770 ที่คลินิกอายุรกรรมโรคอ้วน โรงพยาบาลจุฬาลงกรณ์ ผลการศึกษา ผู้เข้าร่วมวิจัยทั้งหมด 60 คน แบ่งเป็นกลุ่มผู้ป่วยโรคอ้วนที่ได้รับการผ่าตัดกระเพาะเพื่อลดน้ำหนัก 30 คน กลุ่มควบคุม 30 คน จากการศึกษาพบว่าเมื่อเปรียบเทียบกับกลุ่มควบคุม กลุ่มผู้ป่วยมีค่าสัดส่วนเอวต่อสะโพก (waist-hip ratio)(0.83 และ 0.9, P-value <0.001) ร้อยละของไขมันในร่างกาย (percentage of body fat)(ร้อยละ 30.6 และ ร้อยละ 35.9, P-value 0.001) มวลไขมันบริเวณลำตัว (trunk fat mass)(10.3 กิโลกรัม และ 12.4 กิโลกรัม , P-value 0.04) และ มวลรวมกล้ามเนื้อและอวัยวะบริเวณแขนขา (appendicular lean mass)(9 กิโลกรัม และ 16.9 กิโลกรัม, P-value <0.001) น้อยกว่ากลุ่มควบคุม โดยมีค่ามวลรวมกล้ามเนื้อและอวัยวะทั้งร่างกาย (soft lean mass)(47.7 กิโลกรัม และ 39.9 กิโลกรัม, P-value 0.001) มวลรวมกล้ามเนื้อและอวัยวะบริเวณลำตัว (trunk lean mass)(21.2 กิโลกรัม และ 19 กิโลกรัม, P-value 0.02) มวลกล้ามเนื้อลาย (skeletal muscle mass)(27.5 กิโลกรัม และ 23 กิโลกรัม, P-value 0.003) และ มวลกายไร้ไขมัน (fat free mass)(51.1 กิโลกรัม และ 42.3 กิโลกรัม, P-value 0.001) มากกว่ากลุ่มควบคุมอย่างมีนัยสำคัญ และพบว่าหลังผ่าตัดกระเพาะเพื่อลดน้ำหนัก ที่ระยะเวลา 6 เดือน และ 12 เดือน ค่าตัวแปรองค์ประกอบของร่างกายลดลงทั้งหมด โดยเห็นผลลดลงมากสุดที่ระยะเวลา 12 เดือนหลังเข้ารับผ่าตัด สรุปการศึกษา แสดงให้เห็นว่า ในกลุ่มผู้ป่วยโรคอ้วนที่ได้รับการผ่าตัดกระเพาะเพื่อลดน้ำหนัก แม้ค่าตัวแปรองค์ประกอบของร่างกาย เช่น มวลไขมัน มวลกายไร้ไขมัน มวลกล้ามเนื้อ ลดลงทั้งหมดในช่วงตลอดระยะเวลา12 เดือน หลังเข้ารับการผ่าตัด แต่ มวลกล้ามเนื้อ และมวลกายไร้ไขมันในกลุ่มผู้ป่วยนั้น ยังคงสูงกว่าในกลุ่มควบคุมที่อายุ เพศ และค่าดัชนีมวลกายใกล้เคียงกัน

Do The Anatomical And Physiological Properties Of A Muscle Determine Its Adaptive Response To Different Loading Protocols?, Brad J. Schoenfeld, Andrew D. Vigotsky, Jozo Grgic, Cody Haun, Bret Contreras, Kenneth Delcastillo, Aston Francis, Gilda Cote, Andrew Alto

Publications and Research

It has been proposed that superior muscle hypertrophy may be obtained by training muscles predominant in type I fibers with lighter loads and those predominant in type II fibers with heavier loads.

Purpose: To evaluate longitudinal changes in muscle strength and hypertrophy of the soleus (a predominantly slow-twitch muscle) and gastrocnemius (muscle with a similar composition of slow and fast-twitch fibers) when subjected to light (20–30 repetition maximum) and heavy (6–10 repetition maximum) load plantarflexion exercise.

Methods: The study employed a within-subject design whereby 26 untrained young men had their lower limbs randomized to perform plantarflexion with a low-load (LIGHT) …

Role Of Chondrocyte Antigen Presentation In Osteoarthritis, Panjana Sengprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is an inflammatory disorder characterized by degeneration of joint components, especially the cartilage. Chondrocytes are found in articular cartilage and play a role in cartilage production and degradation. Several studies found that chondrocytes not only control the cartilage metabolism, but also play a role in immune responses. However, the role of chondrocytes in the pathogenesis of OA is still unclear. In this study, we investigated the responses of OA chondrocytes after stimulating with IFN-γ and proteoglycan aggrecan and also determined antigen presentation function of chondrocytes to present proteoglycan aggrecan peptide to T cells. We found that OA chondrocyte …

Determining The Role Of Satellite Cells During Skeletal Muscle Adaptation, Davis A. Englund

Theses and Dissertations--Rehabilitation Sciences

Physical inactivity, advancing age, limb immobilization, degenerative diseases and various systemic diseases (many cancers, sepsis, HIV, COPD, kidney disease) all lead to skeletal muscle wasting. The loss of muscle mass is of major clinical importance because it leads to an increased risk for morbidity, disability, and the loss of independence; collectively contributing to a substantive increase in healthcare utilization and cost. The prevalence of cachexia (disease-induced muscle wasting) can reach as high as 80% in certain patient populations and the average cost per hospital stay is $4,641 more than in non-cachectic patients. Direct healthcare costs attributable to sarcopenia were estimated …

A Short Remark On Multipurpose Laser Therapy “Helios” In Ukraine And Its Potential Application For Treatment Of Neurology Disorders, Florentin Smarandache, Volodymyr Krasnoholovets, Victor Christianto, Rizha Vitania, The Houw Liong

Branch Mathematics and Statistics Faculty and Staff Publications

However, a truly multipurpose laser therapy method is very rarely available. Here we introduce a multipurpose laser therapy device in Ukraine, which is capable to take care a multitude of diseases. It is called “Helios”, by one of us (VK). We also give a case where a patient who suffered from Covid-19 has been treated successfully until he is recovered to healthy condition. In the last section we also discuss potential future application of Helios for other fields; i.e. neurology disorders.

Continuous Venovenous Hemodiafiltration In The Treatment Of Newborns With An Inborn Metabolic Disease: A Single Center Experience, Hasan Akduman, Emel Okulu, Fatma Tuba Emi̇noğlu, Tanil Kendi̇rli̇, Gaffari̇ Tunç, Ebru Azapağasi, Oktay Perk, Ömer Erdeve, Begum Atasay, Saadet Arsan

Turkish Journal of Medical Sciences

Background/aim: Most inborn metabolic diseases are diagnosed during the neonatal period. The accumulation of toxic metabolites may cause acute metabolic crisis with long-term neurological dysfunction and death. Renal replacement therapy (RRT) modalities allow the efficient removal of toxic metabolites. In this study, we reviewed our experience with continuous venovenous hemodiafiltration (CVVHDF) as RRT for newborns with an inborn metabolic disease.Materials and methods: Patients diagnosed with an inborn metabolic disease and who received CVVHDF treatment at our neonatal intensive care unit between January 2014 and December 2017 were included in this study. Their demographic and clinical data were collected, and the …

Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi

Turkish Journal of Medical Sciences

Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …

The Use Of Prealbumin As A Predictor Of Malnutrition In Cirrhotic Patients And The Effectof Nutritional Support In Patients With Low Prealbumin Levels, Zuhal Dağ, Hüseyi̇n Köseoğlu, Murat Keki̇lli̇

Turkish Journal of Medical Sciences

Background/aim: Malnutrition is an important and commonly seen prognostic factor in patients with cirrhosis. The diagnosis of malnutrition in cirrhosis patients may be challenging, and an easily measured and widely usable marker is lacking. Prealbumin, however, is an easily measured marker. In the current study we measured prealbumin levels in cirrhotic patients with no clinically apparent malnutrition and used it as a malnutrition marker. Another aim of this study was to evaluate the effect of nutritional support on patient with low prealbumin levels. Materials and methods: Fifty-two patients with Child A and Child B cirrhosis were selected for the study. …

Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar

Turkish Journal of Medical Sciences

Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The …

The Validity And Reliability Of The Turkish Version Of The Body Esteem Scale Foradolescents And Adults (Besaa) For Children, Umut Ece Arslan, Lütfi̇ye Hi̇lal Özcebe, Hande Konşuk Ünlü, Sarp Üner, Mahmut Saadi̇ Yardim, Ozgur Araz, Terry T-K Huang

Turkish Journal of Medical Sciences

Background/aim: Body esteem (BE) is defined as the self-evaluation of one's own body or appearance. The Body Esteem Scale for Adolescents and Adults (BESAA) consists of three subscales: BE-appearance, BE-weight, and BE-attribution. Though initially developed for adolescents and adults, the use of the scale has recently increased in health-related research on children. This study aimed to assess the validity and reliability of the Turkish version of the BESAA for children. Materials and methods: The participants in the study were 4th grade children (aged 9-10 years) in Ankara, Turkey. The validity of the scale was evaluated through exploratory and confirmatory factor …

The Effect Of Vitamin D Status On Different Neuromuscular Blocker Agents Reverse Time, İlknur Sui̇di̇ye Yorulmaz, Yavuz Demi̇raran, Onur Özlü, Burhan Dost

Turkish Journal of Medical Sciences

Background/aim: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times. Material and methods: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was …

Baicalein Nanofiber Scaffold Containing Hyaluronic Acid And Polyvinyl Alcohol: Preparation And Evaluation, Kamel Bachimam, Ezgi̇ Emül, Necdet Sağlam, Feza Korkusuz

Turkish Journal of Medical Sciences

Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue. Materials and methods: Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic …

Posthepatectomy Liver Failure, İlhan Ocak, Serdar Topaloğlu, Koray Acarli

Turkish Journal of Medical Sciences

Liver surgery is one of the most complex surgical interventions with high risk and potential for complications. Posthepatectomy liver failure (PHLF) is a serious complication of liver surgery that occurs in about 10% of patients undergoing major liver surgery. It is the main source of morbidity and mortality. Appropriate surgical techniques and intensive care management are important in preventing PHLF. Early start of the liver support systems is very important for the PHLF patient to recover, survive, or be ready for a liver transplant. Nonbiological and biological liver support systems should be used in PHLF to prepare for treatment or …

Relationship Between Malnutrition And Coronary Microvascular Dysfunction In Patientswith Nonischemic Dilated Cardiomyopathy, Şeref Kul, Tolga Si̇nan Güvenç, Mustafa Çalişkan

Turkish Journal of Medical Sciences

Background/ aim: Malnutrition is common in patients with nonischemic dilated cardiomyopathy (DCM), especially in the end stages of the disease where heart failure symptoms predominate. Malnutrition has been associated with atherosclerosis in patients with chronic kidney disease, but it is unknown whether a similar relationship exists between malnutrition and coronary microvascular dysfunction (CMD). In the present study, we aimed to analyse whether indices of malnutrition were associated with coronary flow reserve (CFR) in patients with DCM. Materials and methods: A total of 33 cases who were prospectively followed up with by institutional DCM registry were found eligible for inclusion. Coronary …

Gut Microbiota And Therapeutic Approaches For Dysbiosis In Irritable Bowel Syndrome:Recent Developments And Future Perspectives, Hanna Fjeldheim Dale, Gülen Arslan Lied

Turkish Journal of Medical Sciences

Increased knowledge regarding the implications of gut microbiota in irritable bowel syndrome (IBS) suggests that a disturbed intestinal microenvironment (dysbiosis) might promote the development and maintenance of IBS symptoms and affects several pathways in the pathology of this multifactorial disease. Accordingly, manipulation of the gut microbiota in order to improve IBS symptoms has evolved as a novel treatment strategy in the last decade. Several different approaches have been investigated in order to improve the gut microbiota composition. Dietary modifications including supplementation with fibers, prebiotics, and probiotics are shown to improve symptoms and composition of gut microbiota in IBS; however, the …

The Role Of Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9 In Enhanced Aggressiveness Of Hexavalent Chromium Transformed Bronchial Epithelial Cells, Peter Van Wie

Theses and Dissertations--Toxicology and Cancer Biology

Hexavalent chromium (Cr(VI)) is classified as a confirmed human carcinogen by the International Agency for Research and Cancer (IARC) and by the U.S. Environmental Protection Agency (EPA). Chronic exposure to (Cr(VI)) causes malignant cell transformation in human bronchial epithelial BEAS-2B cells. These Cr(VI)-transformed cells exhibit a highly aggressive phenotype including increased migration, invasion, and angiogenesis. The Cas family protein neuronal precursor developmentally down regulated protein 9 (NEDD9/Cas-L/HEF1) was dramatically overexpressed in Cr(VI)-transformed cells compared to normal BEAS-2B cells. Knockdown of NEDD9 by its shRNA reduced migration and invasion in vitro measured by migration and invasion assays. shNEDD9 reduced tumor formation …

Functional Impact Of Angiotensinogen Specific Domains On Angiotensin Ii-Mediated Functions, Chia-Hua Wu

Theses and Dissertations--Pharmacology and Nutritional Sciences

Angiotensinogen (AGT) is the only substrate for all angiotensin peptides in the renin angiotensin system (RAS). Cleavage of AGT by renin is a rate-limiting step of angiotensin peptides productions in the RAS and regulates angiotensin peptides-associated pathophysiological functions. Only ten N-terminal residues are cleaved by renin and the functions of remaining part of AGT protein, which is called des(angiotensin I)AGT, remain unclear. Despite of pivotal roles of AGT in the RAS, studies related to how AGT is metabolized and how des(angiotensin I)AGT regulates AGT functions or AngII-mediated functions are limited.

Renin cleavage of AGT shows species specificity. It has been …

Apoe As A Metabolic Regulator In Humans, Mice, And Astrocytes, Brandon C. Farmer

Theses and Dissertations--Physiology

Altered metabolic pathways appear to play central roles in the pathophysiology of late-onset Alzheimer’s disease (AD). Carrier status of the E4 allele of the APOE gene is the strongest genetic risk factor for late-onset AD, and increasing evidence suggests that E4 carriers may be at an increased risk for neurodegeneration based on inherent metabolic impairments. A new appreciation is forming for the role of APOE in cerebral metabolism, and how nutritional factors may impact this role. In chapter 1, the literature on nutritional interventions in E4 carriers aimed at mitigating disease risk is reviewed. Studies investigating the mechanism by which …

Circadian Clock And Lipid Metabolism Disruption In Fatty Liver Disease, Jennifer Valcin

All ETDs from UAB

Hepatic Steatosis, characterized by the accumulation of triglyceride (TG) in the liver is the first stage of Alcoholic Liver Disease (ALD) and Nonalcoholic Fatty Liver Disease (NAFLD). Many metabolic pathways, including lipid metabolism, are regulated by the molecular circadian clock. Importantly, alcohol consumption and obesity induce circadian clock disruption, a risk factor for many diseases, including liver disease. In our first study, we investigated the combined effect of clock disruption and alcohol feeding on liver pathology, and diurnal rhythms in the liver molecular clock and lipid metabolism. Male liver-specific Bmal1 knockout (LKO) mice and control littermates were fed a control …

Genomic-Based Identification Of Environmental And Clinical Listeria Monocytogenes Strains Associated With An Abortion Outbreak In Beef Heifers, Katherine J. Whitman, James L. Bono, Michael L. Clawson, John D. Loy, Joseph M. Bosilevac, Terrance M. Arthur, Jeff D. Ondrak

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: In a beef cattle facility an outbreak of abortions occurred over a 36-day period and included samples from two aborted (non-viable) fetuses and 21 post-abortion clinical cases. There are numerous etiologies, including clinical listeriosis. At the species level, Listeria monocytogenes is ubiquitous in cattle production environments, including soil, feed, and occasionally water sources, and is a common enteric resident of cattle and other mammals. There are four genetically distinct lineages of L. monocytogenes (I-IV), with most lineage III and IV isolates obtained from ruminants. Definitive diagnosis of L. monocytogenes as a causative agent in disease outbreaks relies upon case …

Obese Zucker Rats As A Reverse Translational Model Of Human Left Ventricular Hypertrophy, Mackenzie Shelby Newman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heart failure is a lifelong disability that for over half of those affected leads to mortality within five years after initial diagnosis. Left ventricular hypertrophy (LVH) is one of the most reliable independent predictors of heart failure. Pathological LVH is irreversible, but early diagnosis is often missed due to its asymptomatic nature. Obese Zucker rats (OZR), which develop obesity due to dysfunctional leptin signaling, naturally exhibit a LVH that mimics the obese human condition. Animal models are necessary because human donor tissue is scarce. The central hypothesis is that genes and proteins that are differentially expressed during development of LVH, …

Oral Contraceptives As Possible Acl Injury Prevention Method, Haley Schweizer

Capstone Showcase

ABSTRACT

Introduction: Anterior Cruciate Ligament (ACL) injuries are an upsetting setback for many athletes that require a long and costly recovery process. The injury rates are four times greater in women than men. Preventative measures that help to prevent ACL injuries are limited to stretching and strengthening. Therefore, this review aims to investigate if oral contraceptive [I] usage provides a possible new avenue for prevention of ACL injury [O] in young female athletes (ages 18-30) [P] compared to those that do not take oral contraceptives [C].

Methods: A literature review was performed though PubMed, Google Scholar, SCOPUS Database, and ClinicalKey …

Data-Driven Identification Of Chemopreventive Agents For Breast Cancer, Deni̇z Can Güven, Cemal Orhan, Kazi̇m Şahi̇n, Fatih Mehmet Uçkun

Turkish Journal of Medical Sciences

Preclinical animal models of breast cancer provide the opportunity to identify chemopreventive drugs with single-agent activity as well as effective multi-modality regimens for primary as well as secondary prevention in high-risk persons. Our group has used the 7,12-dimethylbenz(a)anthracene (DMBA) mouse model of carcinogen-induced breast cancer to explore the clinical potential of two tyrosine kinase inhibitors and a nucleoside analog as chemopreventive agents. All three agents exhibited promising preclinical activity both as monotherapy and as components of combination therapy with the standard chemotherapy drug paclitaxel. The tumors developing despite chemoprevention were not only small and grew slowly, but they also displayed …

Effects Of Oral/Enteral Nutrition Alone Versus Plus Pantoprazole On Gastrointestinalbleeding In Critically Ill Patients With Low Risk Factor: A Multicenter, Randomizedcontrolled Trial, Kürşat Gündoğan, Emre Karakoc, Turgut Teke, Avşar Zerman, Ali̇ye Esmaoglu, Şahi̇n Temel, Muhammet Güven, Murat Sungur

Turkish Journal of Medical Sciences

Background/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage. Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleeding in low risk critically ill patients. Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU) patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group (received oral/EN plus pantoprazole) and control group (received only oral/EN). Results: A total of 300 patients (intervention group: 152, control group: 148) participated …

Posterior Fossa Horns; A New Calvarial Finding Of Mucopolysaccharidoses With Well-Known Cranial Mri Features, Çağri Damar, Betül Emi̇ne Deri̇nkuyu, Muazzez Asburçe Bi̇ke Olgaç Kiliçkaya, Mehmet Öztürk, Çi̇ğdem Öztunali, Ayşe Gül Alimli, Öznur Leman Boyunaga, Murat Uçar, Fati̇h Süheyl Ezgü, Leyla Tümer, Alp Özgün Börcek, Ahmet Siğirci

Turkish Journal of Medical Sciences

Background/aim: Mucopolysaccharidoses (MPS) are a group of hereditary metabolic diseases. The aim of this study was to share the previously unreported calvarial finding of internal hypertrophy of the occipitomastoid sutures (IHOMS) together with some other well- known cranial MRI findings in this patient series. Materials and methods: A retrospective evaluation was conducted of 80 cranial MRIs of patients who had been diagnosed and followed up with MPS from 2008 to 2019 in our center. Of these patients, 11 had Hurler, 14 had Hunter, 24 had Sanfilippo, 15 had Morquio, 14 had Maroteaux-Lamy, and 2 had Sly disease. The cranial MRIs …