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Exenatide As Chronopharmacotherapy For T2dm Associated Complications: Targeting Nondipping Blood Pressure And Sleep Insufficiency, Aaron Chacon

Theses and Dissertations--Pharmacology and Nutritional Sciences

Although largely impacted by age, race and ethnicity, and socioeconomic factors, Type 2 Diabetes Mellitus (T2DM) is primarily driven by obesity, currently affecting ~30 million in the U.S and ~463 million globally. T2DM carries numerous complications, including high prevalence of hypertension and nondipping blood pressure (BP), sleep insufficiency and fragmentation. Nondipping BP is an inadequate drop in BP (≤ 10%) during sleeping hours compared with waking hours. Lending to this, sleep disturbance acts as both precursor and consequence of metabolic dysregulation, greatly impacting circadian rhythmicity. To model these conditions, we utilized diabetic (db/db) mice. These mice carry a point mutation …

Nutrient Profile Assessment Of A Meal Program Impact On Older Adults' Diet Quality And Food Security Status, Millicent Yaa Gyasiwaa Ms

Theses and Dissertations--Nutrition and Food Systems

The rise in food insecurity globally has ignited institutions and organizations to implement policies and programs to reduce the burden on vulnerable people including older adults and people living in underserved areas. Though programs such as congregate, home-delivered meals, and pantries have been initiated to contribute to reducing food insecurity the nutrient content of these meals including recovered meals and their effect on food security status, food quality, and health has not been widely studied. The current study, Meals on Wings (MOW), assessed the nutrient profile of the free meals offered 4 times per week for 3 months, from May …

Role Of Social Determinants Of Health And The Renin- Angiotensin Aldosterone System In Risk For Hypertensive Disorders Of Pregnancy And Related Adverse Outcomes., Esther Letushila Ndashaala

Theses and Dissertations--Nutrition and Food Systems

Background: Hypertensive disorders of pregnancy (HDP) represent a significant public health issue, contributing to maternal and fetal morbidity and mortality. Women from lower socioeconomic backgrounds or marginalized racial and ethnic groups face higher risks of HDP, which have been incompletely described. In addition, risk for HDP may be linked to a reduction in the normal activity of the renin-angiotensin-aldosterone system (RAAS). This study investigates the role of socioeconomic factors and RAAS components in the risk for HDP and adverse maternal and neonatal outcomes. Methods: This study is a secondary analysis of data from 180 pregnant individuals from a high-risk maternal-fetal …

Addressing Healthcare Disparities Faced By Aging Down Syndrome Populations, Rhea Mistry

Pitzer Senior Theses

Down syndrome (DS) is a chromosomal genetic condition that impacts the development of the body and brain. The life expectancy of individuals with DS has drastically improved over the decades, increasing from 9 years in 1929 to 25 years in 1983 and further reaching 60 years by 2002. Individuals with DS face a variety of prominent co-occurring health conditions that are subject to change over time, including cognitive, visual, and hearing impairments, sleep apnea, cardiovascular defects, Down syndrome regression disorder, and dementia. Despite this increase in life span, DS is still most familiar to pediatric care providers, resulting in healthcare …

The Role Of Primary Care Providers In Maintaining Weight Loss By Preventing Behavioral Relapse, Hayden R. Blanchard

Capstone Showcase

Supporting patients in optimizing health by treating obesity remains a relevant goal for primary care providers. While weight loss is frequently achieved with behavioral modification, maintaining weight loss by avoiding behavioral relapse is much more difficult. Patient may lose weight by reducing overall energy intake, incorporating intensive behavior change programs, utilizing pharmacotherapy as needed and, in certain cases, undergoing bariatric surgery. With a focus on behavior change and maintenance, primary care providers can support patients by planning more frequent follow up appointments, at least every one to three months. In these visits, PCPs can: focus on reenforcing lifestyle change principles …

Impact Of The Use Of Nutrition Information On Glycemic Control In Adults With Diabetes, Katelyn Richardson

All Master's Theses

The purpose of this study is to examine the association between glycemic control in adults with diabetes and the use of nutrition information (NI). A cross-sectional design evaluated adults with diabetes from the 2009-2010 and 2017-2020 NHANES databases. Use of NI was quantified based on the subject’s use of the Nutrition Facts Label, use of calorie information at restaurants, and use of either the USDA Food Guide Pyramid or My Plate. Glycemic control was established if the subject’s hemoglobin A1C concentration was 7.0% or lower. SAS Software (v. 9.4) was used for all statistical analysis. Differences between prevalences were established …

Incidence, Risk Factors, And Outcome Of Anti-Tuberculosis Drug-Induced Hepatotoxicity In People With And Without Hiv In Thailand And The Philippines, Ryan Christopher Atuel

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Anti-tuberculosis drug-induced hepatotoxicity (DIH) is a common complication among people living with HIV (PLWH), potentially leading to treatment interruptions. Objective: To determine the incidence of DIH and identify risk factors in Thai and Filipino PLWH on tuberculosis (TB) treatment, compared with those with TB mono-infection. Materials and Methods: We conducted a cohort study of Thai and Filipino adults with active TB using retrospective data from Thailand (2000–2024) and prospective data from the Philippines (2024). Eligible participants had AST/ALT results at TB treatment initiation and follow-up. DIH was defined as AST or ALT ≥3 times the upper limit of normal. …

Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr

Journal of Medicine in Scientific Research

Objective: In this article, garden cress and ozone were evaluated for their potential therapeutic properties of PDL and resorption of alveolar bone in the periodontal tissues based on rats' experimental periodontitis and to assess the clinical effectiveness of local application of garden cress and ozone for treatment and management of periodontitis patients using scaling and root planing. Methodology: Thirty mature Wistar male albino rats. Three groups of rats were formed; periodontitis without treatment, periodontitis with garden cress, and periodontitis plus ozone therapy. The present study also included thirty periodontitis Patients were randomly allocated to one of three groups of ten …

Oral And Dental Health In Systemic Sclerosis: Is It A Window To Other Systemic Affections?, Omnia A Abubakr, Taghreed F M M Mostafa, Mohamed A Hamdy

Journal of Medicine in Scientific Research

Background: Oral and periodontal manifestations are common in systemic sclerosis (SSc) which may result in poor nutritional status and significant morbidity. Better understanding of these manifestations is crucial for better patient outcomes. We aimed to evaluate dental and oral manifestations in patients with SSc in comparison to healthy control and to study the relationship between these findings and systemic sclerosis disease activity index, skin thickness, other systemic affection, as well as the oral health-related quality of life in these patients Patients and Methods: 50 patients with SSc were included in this case-control study (Group A) and 50 apparently healthy controls …

The Rage Gene Crucial Function In The Etiology And Consequences Of Type I Diabetes, Amal A. Mohamed, Mohamed O. Mahmoud, Gamil M. Abdallah, Nada S. Ali, Mona Abdelmotaleb Abdelfatah Hussein, Ibrahim T. Ibrahim

Journal of Medicine in Scientific Research

Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It is an auto-immune illness brought on by an association of environmental and genetic variables. that cause T lymphocytes to destroy insulin-producing β-cells. Its prevalence continues to rise by 3-4% annually worldwide, enhancing the risk of mortality. So, the idea of diabetic kidney disease (DKD) is widely established, and systemic treatment is essential. RAGEs are linked to inflammatory disorders that exist in a variety of TID-related cells; especially T cells. Variations in circulating RAGE concentrations have been linked to a …

Oral Collagen Supplementation In 2nd Degree Burn And Chronic Pressure Ulcers, Wesam Ibrahem Homouda, Helmy Ahmed Soliman, Esayed Hussien Elmokadem

Journal of Medicine in Scientific Research

Background: Healing of wounds requires adequate intake of protein, iron, Vitamin-C and zinc. In case of deficiency in the dietary intake, supplements may be prescribed. Collagen-peptide supplements can enhance skin hydration, elasticity, and reduce wrinkles. Burns, caused by various agents, severely damage skin layers. Pressure ulcers occur when prolonged pressure on the skin leads to tissue ischaemia, disrupting nutrition and oxygen supply, resulting in tissue necrosis. Systematic reviews show that oral collagen, either intact or hydrolyzed, effectively improves skin health.

Objectives: This article aim to evaluate the effect of oral collagen intake as a healing promoting supplementation in management of …

Relationship Between Thyroid-Stimulating Hormone (Tsh) Levels And The Presence Of Non-Alcoholic Fatty Liver Disease (Nafld) Among Asymptomatic Individuals, Mohamed Ramzy Alawy, Shimaa M W Kalama, Rania T H Gebba, Samah Mohammed Abdelmonem Abu Sholaa, Asmaa M Soliman

Journal of Medicine in Scientific Research

Background: Thyroid gland and its hormones have a crucial effect in body weight regulation, metabolism of lipid, and insulin sensitivity, which all of them play an important and significant effect in the process of non-alcoholic fatty liver disease (NAFLD) development. Aim: This study aimed to evaluate the potential risk of occurrence of metabolic syndrome in euthyroid persons with NAFLD . Subjects and Methods: - This cross-sectional study was carried out on outpatient cases in the Department of Internal Medicine at Shebin El-Kom Teaching Hospital. Conducted between February 2024 and August 2024, our study included 96 participants recruited from outpatient clinic. …

Serum Procalcitonin As An Early Marker Of Diabetic Foot Sepsis In Shebin Elkom Teaching Hospital, Asmaa M Soliman, Shimaa M W Kalama, Rania T H Gebba, Randa I. Ahmed Elshiha, Samah Mohammed Abdelmonem Abu Sholaa, Elham T Awwad, Mohamed Ramzy Alawy, Mohamed Abdel Samie Abdelkhalek Elbahat

Journal of Medicine in Scientific Research

Background Diabetic foot infections are a serious consequence of diabetes mellitus, frequently resulting in major health problems such as amputation. Traditional diagnostic markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have limitations, spurring more research into procalcitonin (PCT) as a possibly more reliable predictor of infection severity and consequences. Objectives To compare the efficacy of (PCT) to standard inflammatory indicators (ESR and CRP) in predicting outcomes of acute diabetic foot infections (DFI) and to determine its potential benefits in clinical settings. Patient and Methods A cross-sectional study was undertaken at Shebin Elkom Teaching Hospital between December 2023 …

Short Term Effects Of Bariatric Surgeries On Renal And Hepatic Functions On Obese Morbid Patients, Naglaa F. Al-Mihy, Esayed Elmokadem, Atteyat Aboelmaged Semeya

Journal of Medicine in Scientific Research

Background: Bariatric surgery has emerged as a well-established treatment for achieving long-lasting and successful weight reduction. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are currently the most frequently done operations. The aim of this research was to investigate the hepatic and renal alterations following bariatric procedures, with a particular focus on SG.

Methods: This observational prospective cohort research was performed on 100 morbidly obese individuals with BMI ≥40 kg/m² who underwent SG. All patients were evaluated before surgery clinically and all laboratory investigations were done before operation as baseline, 3 months, 6 months after surgery, and after one …

Telemedicine And Physical Visits: A Dynamic Duo In Obesity Management Among Adolescents, Egypt, Enas Sayed Abbas, Safaa Al Hussein Tawfik, Gehan Fouad Ahmad, Lamiaa Ibrahim Haroon, Taghreed K. M. Elhady, Amira Said Nassar

Journal of Medicine in Scientific Research

Childhood obesity, a serious global issue, leads to various health problems like diabetes, high blood pressure, high cholesterol, and psychological issues. In Egypt, inconsistent data shows a significant prevalence of obesity among adolescents, influenced by factors like gender, age, and lifestyle. The study aims to explore the effectiveness of telemedicine, in conjunction with physical visits, for managing obesity among adolescents in Egypt. Telemedicine, a cost-effective and engaging alternative to in-person visits, can help patients lose weight and provide a safe, remote alternative, expanding treatment access to hard-to-reach populations. The study is a controlled clinical trial on overweight or obese adolescents …

Factors Affecting Non-Compliance With Treatment Among Diabetic Students At Sohag University, Rasha Gamal-El-Din Abu-El-Goud, Samah Wagdy Elkhayat, Ahmed Fathy Hamed, Seham Ahmed Abokresha

Journal of Medicine in Scientific Research

Background and objectives: Diabetes mellitus (DM) is a metabolic disease characterized by insufficient insulin synthesis, action, or both. Its prevalence is estimated to be alarmingly increasing. The aim of the study was studying factors influencing the non-compliance of diabetic students at Sohag University with treatment. Methods: Cross-sectional study at Sohag University for 7 months. Total number of diabetic students involved in the study was 153 students chosen from medical reports of administration of medical affairs in the university from May to November 2022; the participants who were studying in a scientific faculty were 51 (33.3%), and in Literary faculty were …

Feasible Diet And Circadian Interventions Reduce In Vivo Progression Of Flt3-Itd-Positive Acute Myeloid Leukemia, Megan Rodriguez, Baharan Fekry, Brianna Murphy, Mary Figueroa, Tiewei Cheng, Margaret Raber, Lisa Wartenberg, Donna Bell, Lisa Triche, Karla Crawford, Huaxian Ma, Kendra Allton, Ruwaida Ahmed, Jaime Tran, Christine Ranieri, Marina Konopleva, Michelle Barton, Cesar Nunez, Kristin Eckel-Mahan, Joya Chandra

Faculty, Staff and Student Publications

BACKGROUND: Acute myeloid leukemia (AML) with an internal tandem duplication in the fms-like tyrosine kinase receptor 3 gene (FLT3-ITD) is associated with poor survival, and few studies have examined the impact of modifiable behaviors, such as nutrient quality and timing, in this subset of acute leukemia.

METHODS: The influence of diet composition (low-sucrose and/or low-fat diets) and timing of diet were tested in tandem with anthracycline treatment in orthotopic xenograft mouse models. A pilot clinical study to test receptivity of pediatric leukemia patients to macronutrient matched foods was conducted. A role for the circadian protein, BMAL1 (brain and muscle ARNT-like …

New-Onset Diabetes Is A Predictive Risk Factor For Pancreatic Lesions In High-Risk Individuals: An Observational Cohort Study, Seyda Baydogan, Chirayu Mohindroo, Merve Hasanov, Maria F Montiel, Pompeyo Quesada, Irina M Cazacu, Adrianna A Luzuriaga Chavez, Maureen E Mork, Wenli Dong, Lei Feng, Y Nancy You, Banu Arun, Eduardo Vilar, Powel Brown, Matthew H G Katz, Suresh T Chari, Anirban Maitra, Eric P Tamm, Michael P Kim, Manoop S Bhutani, Florencia Mcallister

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Pancreatic cancer (PC) is the third cause of cancer-related deaths. Early detection and interception of premalignant pancreatic lesions represent a promising strategy to improve outcomes. We evaluated risk factors of focal pancreatic lesions (FPLs) in asymptomatic individuals at hereditary high risk for PC.

METHODS: This is an observational single-institution cohort study conducted over a period of 5 years. Surveillance was performed through imaging studies (EUS or magnetic resonance imaging/magnetic resonance cholangiopancreatography) and serum biomarkers. We collected demographic characteristics and used univariate and multivariate logistic regression models to evaluate associations between potential risk factors and odd ratios (ORs) …

Linking Artificial Sweetener Intake With Kidney Function: Insights From Nhanes 2003-2006 And Findings From Mendelian Randomization Research, Zhuoling Ran, Yuxuan Zheng, Lin Yu, Yuxian Zhang, Zhenjiang Zhang, Huijie Li, Xuhan Li, Jing Song, Li Zhang, Ran Zhang, Chang Lu, Yang Gong, Jian Gong

Faculty, Staff and Student Publications

BACKGROUND: The current investigation examines the association between artificial sweetener (AS) consumption and the likelihood of developing chronic kidney disease (CKD), along with its impact on kidney function.

METHODS: We utilized data from the National Health and Nutrition Examination Survey from 2003-2006 to conduct covariance analysis and weighted adjusted logistic regression, aiming to assess the association between artificial sweetener intake and CKD risk, as well as kidney function indicators. Subsequently, we employed Mendelian randomization methods to validate the causal relationship between the intake of artificial sweeteners, CKD risk, and kidney function indicators. Instrumental variable analysis using inverse-variance weighting and Robust …

Secondhand Tobacco Smoke Exposure In Homes And Vehicles In Youth: Disparities Among Racial, And Sexual And Gender Minorities, Rajesh Talluri, Sahil S Shete, Surendra S Shastri, Sanjay Shete

Faculty, Staff and Student Publications

BACKGROUND: Secondhand smoke exposure (SHSe) among youth is a serious public health concern, leading to an increased risk of conditions such as asthma and respiratory infections. However, there is little research on SHSe among vulnerable populations, such as racial and sexual minorities. Understanding the factors associated with youth SHSe in homes and vehicles is crucial to developing better protective policies.

METHODS: This study utilized 2020 data from the National Youth Tobacco Survey, a representative sample of middle- and high-school students in the US. The primary outcomes were youth SHSe at home and while riding in a vehicle. Multinomial regression models …

Higher Il-6 And Il-4 Plasma Levels In Depressed Elderly Women Are Influenced By Diabetes Mellitus, Natália S Dias, Antônio L Teixeira, Breno S Diniz, Erica L Vieira, Bernardo De M Viana, Izabela G Barbosa

Faculty, Staff and Student Publications

OBJECTIVE: This study aimed at investigating a set of peripheral cytokines in elderly female patients with MDD, comparing them to controls, and assessing the potential influence of clinical comorbidities on inflammatory markers.

METHODS: Twenty-five elderly female patients diagnosed with MDD and 19 age-matched female controls were enrolled on this study. Plasma levels of interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were evaluated with commercially-available assays.

RESULTS: Elderly female patients with MDD exhibited higher plasma IL-6 and IL-4 levels when compared to controls. In a logistic regression model taking cytokine levels, comorbidities, and age into account, only …

Toxicity In The Era Of Immune Checkpoint Inhibitor Therapy, Synat Keam, Naimah Turner, Fernanda G Kugeratski, Rene Rico, Jocelynn Colunga-Minutti, Rayansh Poojary, Sayan Alekseev, Anisha B Patel, Yuanteng Jeff Li, Ajay Sheshadri, Monica E Loghin, Karin Woodman, Ashley E Aaroe, Sarah Hamidi, Priyanka Chandrasekhar Iyer, Nicolas L Palaskas, Yinghong Wang, Roza Nurieva

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) reinvigorate anti-tumor immune responses by disrupting co-inhibitory immune checkpoint molecules such as programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4). Although ICIs have had unprecedented success and have become the standard of care for many cancers, they are often accompanied by off-target inflammation that can occur in any organ system. These immune related adverse events (irAEs) often require steroid use and/or cessation of ICI therapy, which can both lead to cancer progression. Although irAEs are common, the detailed molecular and immune mechanisms underlying their development are still elusive. To further our understanding …

Predictors Of Obesity In Hypothyroid Patients Under Treatment, Mohamed Zakarya Nooh, Moustafa Mohammed Gaballah Elnagar, Mohammed Abd El-Raouf Korany, Raghda Samy Ahmed El-Meligy Matard, Moustafa Bakrey Hamed Ata

Journal of Medicine in Scientific Research

Objectives: to evaluate obesity and insulin resistance relation in treated hypothyroid patients attending Menoufia university hospital.

Background: Hypothyroidism is a common endocrine disorder resulting from deficient secretion of thyroid hormone. Africa has the highest prevalence (14.2%) while Asia has the lowest prevalence (5.8%). “obesity” is a disease where body fat and body-fat distribution exceed the level considered healthy. Through the production of adipokines adipose tissue affects the activity of the Hypothalamic–pituitary–thyroid (HPT) axis system. Insulin resistance and autoimmune thyroid disease have shown to influence each other.

Patient and methods: Our study included 254 Egyptian hypothyroid patients under treatment …

Silent Signs: The Hidden Impact Of Aseptic Pyuria In Chronic Kidney Disease, Egypt, Ghadir Mohamed Elsawy, Basma Aref Altaweel

Journal of Medicine in Scientific Research

Introduction: This study, Element Type, reflects the prevalence of and clinical significance of aseptic pyuria among CKD patients in Egypt, addressing the vital knowledge gap that exists in understanding what implications this condition presents to the patient. More than 10% of the world's population suffers from chronic kidney disease that is characterized by progressive loss of renal function and requires monitoring of various clinical parameters, including pyuria and white blood cells present in urine. Aseptic pyuria is commonly misunderstood as a UTI and thereby mistreated with unnecessary antibiotic courses due to the presence of white blood cells with no bacterial …

Evaluation Of Iron, Zinc And Vitamin D Deficiencies In Children With Autism Spectrum Disorder At The Hearing And Speech Institute, In Egypt, Azza Samy, Iman Elrouby, Eman S. Eldin, Eman S. Abd El-Ghaffar

Journal of Medicine in Scientific Research

Background Autism spectrum disorder (ASD) is a complex neurodevelopment disorder with a multifactorial etiology. Each iron, zinc and vitamin D are essential for cognitive, behavioral and motor development. Deficiency of any of these micronutrients may affect ASD symptoms.

Objective The aim of this study is to evaluate and compare the level of iron, zinc and vitamin D levels in children with autism spectrum disorder (ASD) with normal children and to associate between the deficiency of these nutrient elements and the severity of ASD symptoms, in order to help in improvement of ASD symptoms by supplying the deficient elements.

Patients and …

Age-Associated Temporal Decline In Butyrate-Producing Bacteria Plays A Key Pathogenic Role In The Onset And Progression Of Neuropathology And Memory Deficits In 3×Tg-Ad Mice, Paula M Chilton, Smita S Ghare, Benjamin T Charpentier, Scott A Myers, Aakarsha V Rao, Joseph F Petrosino, Kristi L Hoffman, John C Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J Sloan, Jingwen Zhang, Christopher B Shields, Gregory E Cooper, Leila Gobejishvili, Scott R Whittemore, Craig J Mcclain, Shirish S Barve

Faculty, Staff and Students Publications

Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer's disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology in AD progression remain largely undetermined. The present work investigated the causal role of age-associated temporal decline in butyrate-producing bacteria and butyrate in the etiopathogenesis of AD. Longitudinal metagenomics, neuropathological, and memory analyses were performed in the 3×Tg-AD mouse model. Metataxonomic analyses showed a significant temporal decline in the alpha diversity marked by a decrease in butyrate-producing bacterial communities and a concurrent reduction in cecal butyrate production. Inferred metagenomics analysis …

Role Of Apolipoprotein B In The Clinical Management Of Cardiovascular Risk In Adults: An Expert Clinical Consensus From The National Lipid Association, Daniel E Soffer, Nicholas A Marston, Kevin C Maki, Terry A Jacobson, Vera A Bittner, Jessica M Peña, George Thanassoulis, Seth S Martin, Carol F Kirkpatrick, Salim S Virani, Dave L Dixon, Christie M Ballantyne, Alan T Remaley

Faculty, Staff and Students Publications

This National Lipid Association (NLA) Expert Clinical Consensus provides an overview of the physiologic and clinical considerations regarding the role of apolipoprotein B (apoB) measurement to guide clinical care based on the available scientific evidence and expert opinion. ApoB represents the total concentration of atherogenic lipoprotein particles in the circulation and more accurately reflects the atherogenic burden of lipoproteins when compared to low-density lipoprotein cholesterol (LDL-C). ApoB is a validated clinical measurement that augments the information found in a standard lipoprotein lipid panel; therefore, there is clinical value in using apoB in conjunction with a standard lipoprotein lipid profile when …

Trpv4 Affects Visual Signals In Photoreceptors And Rod Bipolar Cells, Ye Long, Maxim Kozhemyakin, Samuel M Wu, Ji-Jie Pang

Faculty, Staff and Students Publications

INTRODUCTION: Mechanical sensitive channels expressed in mammalian retinas are effectors of elevated pressure stresses, but it is unclear how their activation affects visual function in pressure-related retinal disorders.

METHODS: This study investigated the role of the transient potential channel vanilloid TRPV4 in photoreceptors and rod bipolar cells (RBCs) with immunohistochemistry, confocal microscopy, electroretinography (ERG), and patch-clamp techniques.

RESULTS: TRPV4 immunoreactivity (IR) was found in the outer segments of photoreceptors, dendrites and somas of PKCα-positive RBCs and other BCs, plexiform layers, and retinal ganglion cells (RGCs) in wild-type mice. TRPV4-IR was largely diminished in the retinas of homozygous TRPV4 transgenic mice. …

Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut

Turkish Journal of Medical Sciences

Background/aim: This study aims to compare the Greulich–Pyle (GP) and Tanner–Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.Materials and methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0–15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was …

The Validity And Reliability Of Ultrasound As A Tool For Assessing Skeletal Muscle Characteristics In The Pediatric Population, Elizabeth Seewer

Theses and Dissertations (ETD)

Annually, around 5 million people in the U.S. are admitted to Intensive Care Units (ICU) due to critical conditions, with pediatric patients comprising 21% of these admissions. Approximately 40% of pediatric ICU (PICU) patients require mechanical ventilation and extended stays, and about 6% result in death. Survivors often face long-term disabilities, including loss of skeletal muscle mass (SMM), a risk factor for morbidity and mortality. Abdominal computed tomography (CT) scans, often performed during PICU admissions, can assess muscle mass but pose risks of increased cost and radiation exposure. While CT and Magnetic Resonance Imaging (MRI) are gold standards for muscle …