Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (1837)
- University of Nebraska - Lincoln (651)
- TÜBİTAK (593)
- Dartmouth College (192)
- Thomas Jefferson University (172)
-
- Himmelfarb Health Sciences Library, The George Washington University (131)
- Touro College and University System (112)
- University of Kentucky (110)
- Chulalongkorn University (99)
- LSU Health New Orleans (93)
- University of Alabama at Birmingham (85)
- University of the Pacific (69)
- University of Nebraska Medical Center (55)
- Lehigh Valley Health Network (43)
- General Organization of Teaching Hospitals and Institutes (GOTHI) (35)
- University of Tennessee Health Science Center (35)
- University of Texas at El Paso (34)
- Zucker School of Medicine at Hofstra/Northwell (32)
- Marshall University (26)
- University of Louisville (26)
- Aga Khan University (25)
- Children's Mercy Kansas City (25)
- Otterbein University (25)
- City University of New York (CUNY) (22)
- Saudi Medical Journal (21)
- Munster Technological University (20)
- Wright State University (20)
- East Tennessee State University (18)
- University of South Carolina (18)
- Old Dominion University (17)
- Keyword
-
- Humans (1212)
- Female (445)
- Animals (397)
- COVID-19 (371)
- Male (355)
-
- Mice (280)
- Adult (238)
- Child (216)
- SARS-CoV-2 (211)
- Middle Aged (172)
- Immunotherapy (153)
- Infant (132)
- Aged (130)
- Anti-Bacterial Agents (125)
- United States (114)
- Adolescent (110)
- Antibodies (104)
- Retrospective Studies (101)
- Child, Preschool (96)
- Preschool (94)
- HIV (90)
- Inflammation (90)
- Bacterial (84)
- Doctor of Philosophy (PhD) Heersink School of Medicine (84)
- Immunology (82)
- HIV Infections (79)
- Vaccine (79)
- Vaccination (76)
- Microbiology (74)
- Neoplasms (73)
- Publication Year
- Publication
-
- Faculty, Staff and Students Publications (991)
- Faculty, Staff and Student Publications (735)
- Turkish Journal of Medical Sciences (593)
- School of Veterinary and Biomedical Sciences: Faculty Publications (329)
- Nebraska Center for Virology: Faculty Publications (264)
-
- Dartmouth Scholarship (191)
- Microbiology, Immunology, and Tropical Medicine Faculty Publications (112)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (93)
- All ETDs from UAB (85)
- InTouch (82)
- All Dugoni School of Dentistry Faculty Articles (69)
- Department of Microbiology and Immunology Faculty Papers (58)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (57)
- School of Medicine Faculty Publications (48)
- Department of Medicine (42)
- Journal of Medicine in Scientific Research (35)
- Theses and Dissertations (ETD) (35)
- Open Access Theses & Dissertations (33)
- Journal Articles (32)
- Center for Medical Ethics and Health Policy Staff Publications (31)
- Dissertations and Theses (Open Access) (30)
- Nursing Student Class Projects (Formerly MSN) (25)
- School of Graduate Studies Faculty Publications (25)
- Department of Medicine Faculty Papers (24)
- Electronic Theses and Dissertations (24)
- Saudi Medical Journal (21)
- Theses and Dissertations (20)
- Journal Articles: Pathology and Microbiology (19)
- Manuscripts, Articles, Book Chapters and Other Papers (19)
- Publications and Research (17)
- Publication Type
- File Type
Articles 3481 - 3510 of 5296
Full-Text Articles in Entire DC Network
Positive Effect Of Restrictions On Antibiotic Consumption, Oğuz Karabay, Gülsüm Kaya, Ertuğrul Güçlü, Azi̇z Öğütlü
Positive Effect Of Restrictions On Antibiotic Consumption, Oğuz Karabay, Gülsüm Kaya, Ertuğrul Güçlü, Azi̇z Öğütlü
Turkish Journal of Medical Sciences
Background/aim: This study aimed to examine the change in the etiology of hospital infections with restricting and releasing of group 2 carbapenems (G2C) (meropenem/imipenem/doripenem). Materials and methods: This study was planned in three periods. Study period 1 (SP-1): Carbapenems were prescribed without restriction by infectious disease specialists. SP-2: G2C prescription was restricted. SP-3: Carbapenem prescription was released. Results: In total, 4443 cases [1053 in SP-1 (23.7%), 1332 in SP-2 (29.9%), and 2085 in SP-3 (46.9%)] were included in the study. Infection rates were 11%, 6.5%, and 7.9% in SP-1, SP-2, and SP-3, respectively (P = 0.001). Acinetobacter spp.-related hospital infection …
Evaluation Of Urinary Incontinence And Quality Of Life In Marriedwomen Aged Between 20 And 49 Years (Sakarya, Turkey), Kevser İlçi̇oğlu, Sevi̇l Şahi̇n, Nebahat Özerdoğan, Alaetti̇n Ünsal
Evaluation Of Urinary Incontinence And Quality Of Life In Marriedwomen Aged Between 20 And 49 Years (Sakarya, Turkey), Kevser İlçi̇oğlu, Sevi̇l Şahi̇n, Nebahat Özerdoğan, Alaetti̇n Ünsal
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the prevalence of urinary incontinence and to evaluate the relationship between urinary incontinence and quality of life in married women. Materials and methods: This is a cross-sectional study conducted among married women aged 20-49 years living in the vicinity of the Çökekler Community Clinic (Family Health Center) in Sakarya, Turkey, from 1 November 2011 to 15 April 2012. The study group consisted of 1161 women. Results: The frequency of urinary incontinence was 71.5% (n = 830). Out of a total of 830 patients with symptoms of urinary incontinence, mixed was the most frequently determined …
Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu
Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu
Turkish Journal of Medical Sciences
Background/aim: Tuberculous peritonitis may be di cult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: irty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: e mean age was 34.1 years (17?79 years), and 146 (98.6%) of the patients were female and 17 (10.4%) were male. e most common complaints of these patients were abdominal pain (77.4%) and abdominal distention (73.5%). Ascites in the …
Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu
Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu
Turkish Journal of Medical Sciences
Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D de ciency and nosocomial infections among intensive care unit (ICU) patients. Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbid conditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h a er admission to the ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes. Infections were evaluated for 28 days, and for the entire duration of ICU stay independently. Multiple logistic regression analysis was performed …
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P. aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined by measuring plasma levels of …
Evaluation Of Two Commercial Assays For The Rapid Confirmation Of Oxa-48 Likecarbapenemases Produced By Klebsiella Pneumoniae, Pi̇nar Zarakolu, Abdullah Tarik Aslan, John Perry
Evaluation Of Two Commercial Assays For The Rapid Confirmation Of Oxa-48 Likecarbapenemases Produced By Klebsiella Pneumoniae, Pi̇nar Zarakolu, Abdullah Tarik Aslan, John Perry
Turkish Journal of Medical Sciences
No abstract provided.
Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu
Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu
Turkish Journal of Medical Sciences
Background/aim: This study was undertaken to identify subjects with human immunodeficiency virus and tuberculosis (HIV/TB) coinfection in a group of HIV-positive patients followed at five different healthcare centers, and to determine the demographic and clinical characteristics of these subjects as well as the predictors of mortality. Materials and methods: A database search for subjects with TB coinfection was performed among 1475 HIV-positive adult patients and a total of 66 individuals were identified with HIV/TB coinfection. Results: There were 66 patients (4.5%) with TB coinfection. Twenty-one percent (n = 14) of the patients with TB coinfection died during the study period …
Complete Genome Sequence Of Moraxella Bovis Strain Epp-63 (300), An Etiologic Agent Of Infectious Bovine Keratoconjunctivitis, John Dustin Loy, Aaron M. Dickey, Michael L. Clawson
Complete Genome Sequence Of Moraxella Bovis Strain Epp-63 (300), An Etiologic Agent Of Infectious Bovine Keratoconjunctivitis, John Dustin Loy, Aaron M. Dickey, Michael L. Clawson
School of Veterinary and Biomedical Sciences: Faculty Publications
We report here the complete closed genome sequence of Moraxella bovis strain Epp-63 (300) (Epp63). This strain was isolated from an infectious bovine keratoconjunctivitis (IBK) case in 1963. Since then, Epp63 has been used extensively for IBK research. Consequently, the genome sequence of Epp63 should help elucidate IBK host-pathogen interactions.
Non-Naturally Occurring Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) And Methods Of Using, Hiep Lai Xuan Vu, Fernando Osorio, William W. Laegreid, Asit K. Pattnaik, Fangrui Ma
Non-Naturally Occurring Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) And Methods Of Using, Hiep Lai Xuan Vu, Fernando Osorio, William W. Laegreid, Asit K. Pattnaik, Fangrui Ma
Nebraska Center for Virology: Faculty Publications
A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 …
Investigation Of The Effect Of Ss-Lactam Antibiotics And Serum On Growth And Gene Expression In Escherichiacoli Strain Jj1886, Eli̇f Bozçal Dağdevi̇ren
Investigation Of The Effect Of Ss-Lactam Antibiotics And Serum On Growth And Gene Expression In Escherichiacoli Strain Jj1886, Eli̇f Bozçal Dağdevi̇ren
Turkish Journal of Medical Sciences
Background/aim: ß-Lactamase-producing Escherichia coli strain JJ1886 is an epidemic clone with high virulence properties. Because this strain can survive in the bloodstream, we aimed here to understand how ß-lactam antibiotics and human serum affect the growth and gene expression of this bacterium. Materials and methods: We report the time-dependent growth effect of normal human serum and heat-inactivated serum, together with ß-lactam antibiotics (including cefotaxime, ceftazidime, and carbenicillin), for E. coli strain JJ1886. Relative gene expression of ß-lactamase-related genes (encoding the ß-lactamase regulator, CTX-M-15, and peptidoglycan glycosyltransferase) and serum survival- associated genes (encoding lipoprotein NlpI, murein lipoprotein, lipopolysaccharide core heptose (I) …
The Use Of Rapid Antigen Testing And Matrix-Assisted Laser Desorption/Ionization-Timeof Flight Mass Spectrometry In The Diagnosis Of Group A Beta-Hemolytic Streptococci Inthroat Swab Samples, Ridvan Deni̇z, Eli̇f Aktaş Sepetci̇, Ayşe Bariş, Banu Bayraktar
The Use Of Rapid Antigen Testing And Matrix-Assisted Laser Desorption/Ionization-Timeof Flight Mass Spectrometry In The Diagnosis Of Group A Beta-Hemolytic Streptococci Inthroat Swab Samples, Ridvan Deni̇z, Eli̇f Aktaş Sepetci̇, Ayşe Bariş, Banu Bayraktar
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the efficacy of a rapid antigen test in detecting group A beta-hemolytic streptococci (GAS) in throat samples in comparison with the culture method and to compare the efficiency of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and traditional methods in identifying GAS in cultures. Materials and methods: A total of 3668 throat samples from patients with a prediagnosis of tonsillopharyngitis were assessed by the QuickVue+Strep A antigen test and culture. For GAS identification from cultures, bacitracin sensitivity, PYR, and latex agglutination tests and MALDI-TOF MS were used. Results: A total of 567 (15.5%) …
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess expression changes of serum sPD-1 levels in HBeAg-positive chronic hepatitis B patients with entecavir treatment and explore the correlation with the curative effect. Materials and methods: A total of 220 HBeAg-positive CHB patients and 207 healthy individuals were included. sPD-1 levels and virological and biochemical responses were assessed at baseline and at 12, 24, and 48 weeks in CHB patients a er antiviral therapy. Results: sPD-1 levels in HBeAg-positive CHB patients before treatment were signi cantly lower than those of healthy controls. After entecavir treatment, sPD-1 levels increased gradually over time. At 48 weeks …
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Turkish Journal of Medical Sciences
Background/aim: Nocardia is an opportunistic pathogen that mostly a ects hosts with immune de ciencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is di cult to con rm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. us, further knowledge on the clinical characteristics of Nocardia infection is required. Hence, this study aimed to review the demographics, comorbidities, clinical presentation, microbiology, treatment, and outcomes of Nocardia infections in Yantai. Materials and …
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Turkish Journal of Medical Sciences
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method. Results: At 10% ABS successfully inhibited the biofilm formation of the tested microorganisms. Enzyme inhibition analysis revealed that …
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the effect of biologic drugs on the tuberculin skin test in patients with juvenile idiopathic arthritis. Materials and methods: A total of 234 biologic drug-using juvenile idiopathic arthritis patients and 45 healthy controls were enrolled in the study. The tuberculin skin test results of the patients, which had been routinely provided during follow-up, were obtained from the patient files. Tuberculin skin test values of ≥ 5 mm were considered to be positive. Results: The mean diameter of tuberculin skin test induration was 4.99 ± 6.84 mm (IQR: 0-10 mm) and 7.83 …
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Materials and methods: This prospective study enrolled all consecutive patients from two tertiary hospitals who underwent diagnostic or therapeutic thoracentesis. In a cohort of 149 subjects with pleural effusion, including transudates and malignant (MPE), tuberculous (TPE), and parapneumonic effusion (PPE), serum and pleural effusion PTX-3 concentration measurements were performed using ELISA. Serum and pleural effusion protein, lactate dehydrogenase, C-reactive protein …
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
Turkish Journal of Medical Sciences
Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study's aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease. Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information, laboratory and imaging test parameters, Ranson's criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), …
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Turkish Journal of Medical Sciences
Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats. Materials and methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Whole blood, liver, and lung samples were obtained from rats of 3 groups (n = 10 for each group, n total = 30: control as a wild-type group, laparotomy group (LAP), and CLP). Gene expression of MPO and CD177 in targeted …
Evaluation Of The Performance Of Maldi-Tof Ms And Dna Sequence Analysis In The Identification Of Mycobacteria Species, Işin Akyar, Cengi̇z Çavuşoğlu, Meltem Ayaş, Süheyla Sürücüoğlu, Zeynep Arzu İlki̇, Deni̇z Ece Kaya, Yeşi̇m Beşli̇
Evaluation Of The Performance Of Maldi-Tof Ms And Dna Sequence Analysis In The Identification Of Mycobacteria Species, Işin Akyar, Cengi̇z Çavuşoğlu, Meltem Ayaş, Süheyla Sürücüoğlu, Zeynep Arzu İlki̇, Deni̇z Ece Kaya, Yeşi̇m Beşli̇
Turkish Journal of Medical Sciences
Background/aim: Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is an alternative way of identifying mycobacteria via the analysis of biomolecules. It is being increasingly used in routine microbiology practice since it permits early, rapid, and cost-effective identification of pathogens of clinical importance. In this study, we aimed to evaluate the efficacy of phenotypic identification of mycobacteria by the MALDI-TOF MS MBT Mycobacteria Library (ML) 4.0 (Bruker, Daltonics) compared to standard sequence analysis. Materials and methods: A total of 155 Mycobacterium clinical and external quality control isolates, comprising nontuberculous mycobacteria (NTM) (n = 95) and the Mycobacterium tuberculosis complex (MTC) (n …
The Role Of Neurokinin Receptors And Satellite Glial Cells In Herpes Simplex Virus 1 Latency, Andrew Jerome
The Role Of Neurokinin Receptors And Satellite Glial Cells In Herpes Simplex Virus 1 Latency, Andrew Jerome
Wayne State University Dissertations
The ability of herpes simplex virus 1 (HSV-1) to establish a lifelong infection in neurons of the trigeminal ganglion (TG) make it a constant public health threat. Viral reactivation from its latent state is currently the leading cause of viral induced blindness in the United State, as well as the leading cause of herpes simplex encephalitis. Unfortunately, how the virus is able to both establish and maintain its latent state in the TG is not well understood. The purpose of this work was to better understand how neuropeptide signaling through neurokinin receptors, as well as how satellite glial cells (SGCs) …
Optimisation Of Ion Exchange Chromatography Purification Protocols For A Staphylococcal Peptidoglycan Degrading Hydrolase Enzyme, Fiona Maher
Theses
Bacteriophage (phage) are the most abundant biological entities on earth and were first discovered by d’Herelle in 1917. They are found wherever their hosts live and, like all viruses they do not have the ability to make their own protein. Therefore, in order to reproduce, phage must invade and infect bacterial cells. This project focused on the optimisation of Ion Exchange Chromatography purification protocols for a staphylococcal peptidoglycan degrading hydrolase enzyme (CHAPk). The project objective was to obtain the greatest yield of enzyme from the growth of the E.coU XL 1-Blue expression system into which the vector pQE60 was previously …
Gene Knockout Of Prfa And The Arginine Deiminase Pathway In Listeria Monocytogenes, Kearstin Edmonds
Gene Knockout Of Prfa And The Arginine Deiminase Pathway In Listeria Monocytogenes, Kearstin Edmonds
Online Theses and Dissertations
Listeria monocytogenes is a Gram-positive facultative intracellular pathogen. This species is a common cause of food-borne illness outbreaks with high fatality rates. L. monocytogenes is known to produce a number of virulence factors, including enzymes and toxins, which are involved in the disease process. The arginine deiminase pathway has the ability to regulate acidic environments by converting arginine to ammonia, ornithine, and ATP. With the help of a membrane-bound antiporter, the ornithine is transported out of the cell while the ammonia is converted to ammonium. The ATP by-product can also be used with the F0F1-ATPase system to help maintain homeostasis. …
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV). Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 …
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections (DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes. Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospital with a diagnosis of DFI (PEDIS classification 3-4) during 2005-2016 were analyzed according to the presence of PAD. Results: Of 112 patients who were included in this study, 86 (76.8%) had PAD. Patients with PAD were older and had higher amputation rates (P < 0.05). A microbiological profile of patients revealed a predominance of gram-positive bacteria (57.1%). Staphylococcus aureus and Streptococcus spp. were the most frequently encountered bacteria. Incidence of Pseudomonas spp. infection was higher in the PAD group (P < 0.05). Of all patients, 24.1% had multidrug-resistant (MDR) microorganisms in their wound cultures. Presence of MDR bacteria in patients with PAD was 4.9-fold higher than that in patients without PAD (P < 0.05). Conclusion: This retrospective study indicates that PAD has a significant role, especially in elderly patients with DFIs. Patients should be promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord …
Onchocerca Volvulus: The Road From Basic Biology To A Vaccine., Sara Lustigman, Benjamin L. Makepeace, Thomas R. Klei, Simon A. Babayan, Peter Hotez, David Abraham, Maria Elena Bottazzi
Onchocerca Volvulus: The Road From Basic Biology To A Vaccine., Sara Lustigman, Benjamin L. Makepeace, Thomas R. Klei, Simon A. Babayan, Peter Hotez, David Abraham, Maria Elena Bottazzi
Department of Microbiology and Immunology Faculty Papers
Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into …
Brain Is A Potential Sanctuary For Subtype C Hiv-1 Irrespective Of Art Treatment Outcome, For Yue Tso, Guobin Kang, Eun Hee Kwon, Peter Julius, Qingsheng Li, John T. West, Charles Wood
Brain Is A Potential Sanctuary For Subtype C Hiv-1 Irrespective Of Art Treatment Outcome, For Yue Tso, Guobin Kang, Eun Hee Kwon, Peter Julius, Qingsheng Li, John T. West, Charles Wood
Nebraska Center for Virology: Faculty Publications
Subtype C HIV-1 is responsible for the largest proportion of people living with HIV-1 infection. However, there is limited information about the roles of the brain and its cell types as a potential sanctuary for this subtype and how the sanctuary may be affected by the administration of anti-retroviral therapy (ART). To address this issue, we collected postmortem brain tissues from ART treated HIV-1 infected Zambian individuals who experienced complete viral suppression and those who did not. Tissues from various brain compartments were collected from each individual as frozen and formalin-fixed paraffin embedded brain specimens, for detection and quantification of …