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Rh Subgroups And Kell Antigens In Patients With Thalassemia And In Donors In Turkey, Duran Canatan, Ni̇lgün Acar, Banu Kiliç Jan 1999

Rh Subgroups And Kell Antigens In Patients With Thalassemia And In Donors In Turkey, Duran Canatan, Ni̇lgün Acar, Banu Kiliç

Turkish Journal of Medical Sciences

Alloimmunization can be a significant complication of transfusion therapy in patients with thalassemia and hemoglobinopathies. The aim of this study was to investigate Rh and Kell antigens in patients with thalassemia major and in donors in Turkey. A total of 3061 donors and 155 thalassemic patients from three different blood donation centers in Turkey were the subjects of this study. Antigens of Rh and Kell were determined using the Diamed Gel Test. The results of Rh haplotype tests in the thalassemic patients were 40.0% R1, 35.8% r, 19.8% R2, 2.8% R0, 1.4% r'; and in the donors were 46.7% R1, …

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Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley Jan 1999

Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley

Selected Works Temporary Series

No abstract provided.

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Research Fundamentals: V. The Use Of Laboratory Animal Models In Research, Brian J. O'Neil, Jeffrey A. Kline, Keith Burkhart, John Younger Jan 1999

Research Fundamentals: V. The Use Of Laboratory Animal Models In Research, Brian J. O'Neil, Jeffrey A. Kline, Keith Burkhart, John Younger

Biomedicine and Animal Models in Research Collection

Animal research has provided important information about many aspects of the pathophysiology of human disease. Well-performed animal studies can determine the potential benefit of many proposed therapeutic interventions, and experimental results from animal studies have served as the basis for many landmark clinical trials. Many animal research models are described in the research literature, and choosing the appropriate model to answer a research question can be a daunting task. Even more challenging is developing a new model when none of the existing systems are relevant to the proposed question. This article was prepared by members of the SAEM Research Committee …

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Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley Jan 1999

Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley

Departmental Papers (Biology)

No abstract provided.

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Uwomj Volume 69, No 2, Spring 1999, Western University Jan 1999

Uwomj Volume 69, No 2, Spring 1999, Western University

University of Western Ontario Medical Journal

An interdisciplinary medical science publication; established 1930.

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Functionally Dissociating Aspects Of Event Memory: The Effects Of Combined Perirhinal And Postrhinal Cortex Lesions On Object And Place Memory In The Rat., T J Bussey, J L Muir, J P Aggleton Jan 1999

Functionally Dissociating Aspects Of Event Memory: The Effects Of Combined Perirhinal And Postrhinal Cortex Lesions On Object And Place Memory In The Rat., T J Bussey, J L Muir, J P Aggleton

Brain and Mind Institute Researchers' Publications

Reciprocal interactions between the hippocampus and the perirhinal and parahippocampal cortices form core components of a proposed temporal lobe memory system. For this reason, the involvement of the hippocampus in event memory is thought to depend on its connections with these cortical areas. Contrary to these predictions, we found that NMDA-induced lesions of the putative rat homologs of these cortical areas (perirhinal plus postrhinal cortices) did not impair performance on two allocentric spatial tasks highly sensitive to hippocampal dysfunction. Remarkably, for one of the tasks there was evidence of a facilitation of performance. The same cortical lesions did, however, disrupt …

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Status Of Trace Elements Level In Blood Samplesof Different Age Population Of Karachi (Pakistan), Majid Mumtaz, Azhar Siddique, Nadia Mukhtar, Tabassum Mehboob Jan 1999

Status Of Trace Elements Level In Blood Samplesof Different Age Population Of Karachi (Pakistan), Majid Mumtaz, Azhar Siddique, Nadia Mukhtar, Tabassum Mehboob

Turkish Journal of Medical Sciences

No abstract provided.

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Effects Of Nerve Growth Factor On Acetylcholinesterase Activity Of Injured Spinal Cord, Süleyman Baykal, Savaş Ceylan, Haydar Usul, Yüksel Ali̇yazicioğlu, Hasan Efe, Kayhan Kuzeyli̇, Soner Duru, Fadil Aktürk Jan 1999

Effects Of Nerve Growth Factor On Acetylcholinesterase Activity Of Injured Spinal Cord, Süleyman Baykal, Savaş Ceylan, Haydar Usul, Yüksel Ali̇yazicioğlu, Hasan Efe, Kayhan Kuzeyli̇, Soner Duru, Fadil Aktürk

Turkish Journal of Medical Sciences

Fourteen rats were examined and divided into two groups of 7: the control (Group a) and NGF-treated animals (Group B). All animals received a 50 g clip-compression injury to tthe spinal cord at the T9 level. In the NGF-treated animals, NGF (0.1 mg/kg NGF) was injected subcutaneously for seven days. After spinal cord injury, the mean AChE activity was 41.47±1.7122 activated substrate min/ml/gr. wet tissue and 47.52±1.471 in NGF-treated animals. The difference between Groups A and B was statistically significant (p

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A Review Of The Anticoagulant Pesticide Pindone, Laurie E. Twigg, Tim J. Lowe, Gary R. Martin, Garry S. Gray Jan 1999

A Review Of The Anticoagulant Pesticide Pindone, Laurie E. Twigg, Tim J. Lowe, Gary R. Martin, Garry S. Gray

Books & book chapters

A review of the use of pindone for rabbit control in Western Australia is timely due to increased public concern over the use of this toxin, and because non-target deaths of some native Australian animals have been known to occur following its use. Pindone is one of the first generation indandione anticoagulant rodenticides which were developed in the late 1940' s. The toxicity of anticoagulants arises from their inhibition of vitamin K-dependent clotting factors in the blood. Thus therapeutic administration of vitamin K provides a reliable antidote against anticoagulant poisoning. Pindone is slow acting and works best with repeated small …

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Cardiovascular Disease Risk Factors In Women Working In A Tobacco Plant, Bahatti̇n Adam, Abdulkeri̇m Bedi̇r, Cumhur Kilinç, Şennur Arslan, Muhli̇se Alvur Jan 1999

Cardiovascular Disease Risk Factors In Women Working In A Tobacco Plant, Bahatti̇n Adam, Abdulkeri̇m Bedi̇r, Cumhur Kilinç, Şennur Arslan, Muhli̇se Alvur

Turkish Journal of Medical Sciences

To estimate the effect of exposure to tobacco dust on lipid parameters that increase the incidence of cardiovascular disease (CVD), 70 female workers were selected from the tobacco processing section of a tobacco plant, and 55 women were selected from the administration selection as the controls. The subjects were homogeneous in terms of primary and secondary risk factors such as age, alcohol intake, menstrual status, physical activity, diet, familial hyperlipidemia and heart disease. They were divided into two subgroups, smokers and nonsmokers. Venous blood and morning urine samples were simultaneously taken from workers after a 12-14 h period without food …

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Is The Serum Ca125 Level Originating Fromendometrum Influenced By Exogenous Estrogenadministration?, Neşe Ilgin Karabacak, Onur Karabacak, Bülent Tiraş, Rifat Gürsoy, Özdemi̇r Himmetoğlu, Sehri̇ Elbeg Jan 1999

Is The Serum Ca125 Level Originating Fromendometrum Influenced By Exogenous Estrogenadministration?, Neşe Ilgin Karabacak, Onur Karabacak, Bülent Tiraş, Rifat Gürsoy, Özdemi̇r Himmetoğlu, Sehri̇ Elbeg

Turkish Journal of Medical Sciences

Objectives: To assess the endometrial contribution of serum CA125 and its influence from estrogen administration in menopausal women. Desing: A randomised, controlled, prospective study. Materials and Methods: Twenty menopausal women with intact uterus and ovaries (study group) and ten cases with total hysterectomy were selected through a random table among the referred menopause patients for hormone replacement therapy. Mean ages and menopause lengths of the study and control groups were similar. Ten cases and five controls had 15 days of transdermal 100 µm/d estradiol (TE) (group 2), and similarly the other cases with five controls had estradiol were measured at …

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Osteopoikilosis: Report Of A Familial Case, Ercan Tunç, Serpi̇l Savaş Jan 1999

Osteopoikilosis: Report Of A Familial Case, Ercan Tunç, Serpi̇l Savaş

Turkish Journal of Medical Sciences

No abstract provided.

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Radioisotopic Evaluation Of Malignant Lung Tumors: A Technetium-99m-Methoxy-Isobutylisonitrile Study, Murathan Şahi̇n, Ayşenaz Özcan, İrem Bernay, Tarik Başoğlu, Ari̇f Engi̇n Demi̇rçali, Oğuz Uzun, Levent Erkan Jan 1999

Radioisotopic Evaluation Of Malignant Lung Tumors: A Technetium-99m-Methoxy-Isobutylisonitrile Study, Murathan Şahi̇n, Ayşenaz Özcan, İrem Bernay, Tarik Başoğlu, Ari̇f Engi̇n Demi̇rçali, Oğuz Uzun, Levent Erkan

Turkish Journal of Medical Sciences

Tumor imaging with myocardial perfusion agents has been a focal point for researchers. A kinetic study with 99m Technetium- methoxyisobutylisonitrile ( 99m Tc-MIBI) was performed to evaluate the tumor uptake of this radiopharmaceutical in lung cancer. Thirty-five patients with lung cancer were studied. In 21 (60%) patients, there were regions of high uptake of 99m Tc-MIBI in the lesions. Heart/tumor (H/T), heart/lung (H/L) and tumor/lung (T/L) ratios were obtained. H/T and H/L ratios were 1.66±0.22 and 2.10±0.28 in 2-3 min, and 1.69±0.25 and 2.14±0.27 in 29-30 min respectively. The T/L ratio was 1.28±0.10 in 2-3 min and 1.29±0.14 in 29-30 …

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Lupus Anticoagulant And Anticardiolipinantibodies In Unexplained Fetal Losses, Güli̇nnaz Alper, Ege Nazan Tavmergen, Yasemi̇n Kabasakal, Taner Onat Jan 1999

Lupus Anticoagulant And Anticardiolipinantibodies In Unexplained Fetal Losses, Güli̇nnaz Alper, Ege Nazan Tavmergen, Yasemi̇n Kabasakal, Taner Onat

Turkish Journal of Medical Sciences

Lupus anticoagulant (LA) and anti-cardiolipin antibodies (ACAs) are acquired antiphospholipid antibodies (APAs), which are considered to be important markers for pregnancy losses and intrauterine fetal demise. LA and ACAs have anticoagulant effects in vitro and thrombotic effects in vivo and are considered to be the cause of recur-rent pregnancy losses (RPLs), resulting from placental vascular thrombosis and infarction. The aim of this study was to identify the most sensitive and specific method of deter-mining APA positivity and to evaluate the prevalence of APA in patients with unex-plained RPL. The experiment consisted of 25 women with unexplained RPL, the patient group, …

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Psychosocial Influence Of Iddm On Children And Young Patients, Şükrü Hatun, Burhanetti̇n Kaya, Temel Yilmaz, Serpi̇l Salman, Zuhal Sağlam, Mehmet Sargin, Ahmet Şengül, Fati̇h Salman, Yücel Yilmaz Jan 1999

Psychosocial Influence Of Iddm On Children And Young Patients, Şükrü Hatun, Burhanetti̇n Kaya, Temel Yilmaz, Serpi̇l Salman, Zuhal Sağlam, Mehmet Sargin, Ahmet Şengül, Fati̇h Salman, Yücel Yilmaz

Turkish Journal of Medical Sciences

In this study, we evaluated 39 patients, who had been followed up in various centers, in order to determine the psychosocial effects of IDDM on children and young patients. The mean age of the patients was 15.58±2.29 years and the mean duration of diabetes was 4.41±3 years. We measured the depression and self-esteem scores in all patients using a standardized questionnaire for Turkish children. Depression was found in four patients (10.3%), and the self-esteem scores of all patients were within the normal range. There was no correlation betwenn depression or self-esteem scores and age, sex, puberty, duration of diabetes or …

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The Effect Of Acute Exercise On Skin Potential In Trained Athletes, Uğur Tarik Turaçlar, Sena Erdal, Abdullah Arslan, Ahmet Yildiz Jan 1999

The Effect Of Acute Exercise On Skin Potential In Trained Athletes, Uğur Tarik Turaçlar, Sena Erdal, Abdullah Arslan, Ahmet Yildiz

Turkish Journal of Medical Sciences

Endosomatic electrodermal activity (skin potential level, skin potential response and latency) as an indirect indicator of sympathetic nervous system activity was measured in 22 trained athletes during resting and after acute exercise. The aim of this study was to investigate the difference in skin potential parameters in trained atheletes before and after acute exercise on a bicycle ergometer. Skin potential level (SPL) increased (p

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The Report Of 59 Patients With Renalamyloidosis, Sai̇me Paydaş Jan 1999

The Report Of 59 Patients With Renalamyloidosis, Sai̇me Paydaş

Turkish Journal of Medical Sciences

We studied a group of 59 cases with renal amyloidosis. Mean age (45 male, 14 female) was 33.05±13.04 years. All of the cases had secondary amyloidosis. The causes of secondary amyloidosis were as follows: familial mediterranean fever (FMF) 18(30.5%), pulmonary tuberculosis 12(20.33%), chronic osteomyelitis 8(13.55), bronchiectasia 9(15.25%) rheumatic diseases 4(6.4%), Castleman's disease 1(1.6%), unknown etiology 7(11.86%) Hypertension was detected in 15.3% of the cases. In patients with less than 20 ml/min creatinine clearance (Ccr) hypertension was 20%. Hypotension was detected in 6 patients, all of these cases had severe hypoalbuminemia (3.5 g/day) was found in 75% of cases. Daily proteinuria …

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Hemangioma Of The Lumbar Sympatheticganglion, Fahri̇ Yilmaz, Ali̇ Kemal Uzunlar, Mehmet Yaldiz, Adem Arslan, Cemal Özçeli̇k Jan 1999

Hemangioma Of The Lumbar Sympatheticganglion, Fahri̇ Yilmaz, Ali̇ Kemal Uzunlar, Mehmet Yaldiz, Adem Arslan, Cemal Özçeli̇k

Turkish Journal of Medical Sciences

No abstract provided.

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The Anti-Inflammatory Effects Of N^G-Nitrol-Arginine (L-Name) And Steroid In Concanavalina-Induced Uveitis, Hamdi̇ Er, Erhan Üzmez, Naki̇ Doğan, Tongabay Cumhurcu Jan 1999

The Anti-Inflammatory Effects Of N^G-Nitrol-Arginine (L-Name) And Steroid In Concanavalina-Induced Uveitis, Hamdi̇ Er, Erhan Üzmez, Naki̇ Doğan, Tongabay Cumhurcu

Turkish Journal of Medical Sciences

The objective of this study was to compare the anti-inflammatory effects of NG -nitro L-arginine (L-NAME) and corticosteroid in Concanavalin A-induced uveitis in rats. Sixteen male Wistar rats were used. After general anesthesia, intravitreal 0.1 ml Concanavalin A (100mg/ml) was injected into the left eyes of the rats. The animals were divided into 3 groups: group 1 (6 animals) received intraperitoneal 0.2 ml L-NAME (200 mg/kg) 1 hour before, 1 day and 3 days after Concanavalin A injection, group 2 (6 animals) received tropical 1% prednisolone acetate four times a day for 3 weeks, group 3 (4 animals) received an …

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Rate Of Carriage, Serotype Distribution And Penicilin Resistance Of Streptococcus Pneumoniae In Healty Children, Burçi̇n Şener, Sevtap Arikan, M. Alper Ergi̇n, Ayfer Günalp Jan 1999

Rate Of Carriage, Serotype Distribution And Penicilin Resistance Of Streptococcus Pneumoniae In Healty Children, Burçi̇n Şener, Sevtap Arikan, M. Alper Ergi̇n, Ayfer Günalp

Turkish Journal of Medical Sciences

The purpose of this study was to define carriage rates for Streptococcus pneumoniae in a given population in Ankara and also to determine the sertypes and penicilin resistance of these strains. Oropharyngeal swabs were taken from a total of 661 children between 1 and 11 years of age living in a province of Ankara between January 1995 and January 1997. Serotyping was performed by detection of the Quellung reaction. Penicilin susceptibilities of the isolates were screened by agar dilution method according to the guidlines of the National Committe for Clinical Laboratory Standards (NCCLS). The total rate of pneumococcal carriage in …

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Nonlinear Approach To Characterization Oftemporomandibular Joint Vibrations, Murat Pehli̇van, Ahmet Saraçoğlu, Yeşi̇m Şahi̇n, Alexander Andrushchenko, Gürbüz Çelebi̇, Bi̇rgül Özpinar, Simin Hepguler, Berran Öztürk Jan 1999

Nonlinear Approach To Characterization Oftemporomandibular Joint Vibrations, Murat Pehli̇van, Ahmet Saraçoğlu, Yeşi̇m Şahi̇n, Alexander Andrushchenko, Gürbüz Çelebi̇, Bi̇rgül Özpinar, Simin Hepguler, Berran Öztürk

Turkish Journal of Medical Sciences

A new approach is proposed to characterize and discriminate temporomandi-bular joint vibrations. It consists of three steps. First, signals recorded during each cycle of mandibular movement are unified into a single time series. Second, this time series is embedded in some multidimensional space. Third, nonlinear analysis methods are applied to extract the pertinent signal characteristics. In this way two groups of signals have been characterized; those in the first group were recorded from patients whose post-treatment results werebad and the ones in the second group were recorded from patients whose post-treatment results were good. But patients in both groups had …

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Frequency And Distribution Of Risk Factors Forcoronary Heart Disease In The Adult Populationof Rural District Of Elazığ, Turkey, Yasemi̇n Açik, R. Erol Sezer, Hafi̇ze Sezer Jan 1999

Frequency And Distribution Of Risk Factors Forcoronary Heart Disease In The Adult Populationof Rural District Of Elazığ, Turkey, Yasemi̇n Açik, R. Erol Sezer, Hafi̇ze Sezer

Turkish Journal of Medical Sciences

Objectives: This study was performed to determine the frequency and distribution of risk factors for coronary heart disease in people living in the Baskil district of Elazığ. Methods: From a population of 905 individuals aged 35 years and over, 388 were randomly selected. Selection of subjects was done with official records of the Baskil Health Care Center. Although repeated invitations were made, 32 individuals (29 men and 3 women) did not participate. Thus, 356 subjects were enrolled. Blood cholesterol and blood pressure levels, body height and weight were measured in all study subjects. In addition, a questionnaire was applied. Results: …

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The Effect Of Hepatic Plexus Vagectomy On Thesphincter Of Oddi In Hummans, Osman Güler, Meti̇n Aydin, Muammer Karaayvaz, Osman Nuri̇ Di̇lek Jan 1999

The Effect Of Hepatic Plexus Vagectomy On Thesphincter Of Oddi In Hummans, Osman Güler, Meti̇n Aydin, Muammer Karaayvaz, Osman Nuri̇ Di̇lek

Turkish Journal of Medical Sciences

Right upper quadrant billary type pain is classified in three types. Biliary group lll patients have only biliary type pain that is due to sphincter of Oddi dyskinesia and without any abnormalities. In these patients, endoscopic sphincterotomy is a current treatment method that is performed to decrease the choledochal pressure and to facilitate bile flow into the duodenum. In this prospective study, the effect of hepatic plexus vagectomy as an adjunct to cholecystectomy on the sphincter of Oddi was investigated in biliary group lll patients who were potential sufferers of postcholecystectomy syndrome. Common bile duct pressures in 62 cholelithiasis patients …

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Testicular Ultrasound And Biopsy Findings Incases Of Acute Lymphoblastic Leukemia, Ertan Kayseri̇li̇, Pami̇r Gülez, Sertaç Sözer Arslanoğlu, Canan Vergi̇n, Füsun Atlihan, Ragip Ortaç, Nazahat Argon, İrfan Karaca Jan 1999

Testicular Ultrasound And Biopsy Findings Incases Of Acute Lymphoblastic Leukemia, Ertan Kayseri̇li̇, Pami̇r Gülez, Sertaç Sözer Arslanoğlu, Canan Vergi̇n, Füsun Atlihan, Ragip Ortaç, Nazahat Argon, İrfan Karaca

Turkish Journal of Medical Sciences

No abstract provided.

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Infantile Galactosialidosis Associated Withvitamin D Deficiency Rickets, Koray Boduroğlu, Ergül Tunçbi̇lek, Turgay Coşkun, Canan Uçar Jan 1999

Infantile Galactosialidosis Associated Withvitamin D Deficiency Rickets, Koray Boduroğlu, Ergül Tunçbi̇lek, Turgay Coşkun, Canan Uçar

Turkish Journal of Medical Sciences

Galactosialidosis is an autosomal recessive disease with combined deficiency of two lysosomal enzymes due to the lack of a protective protein. We report on a boy with infantile galactosialidosis who has an intermediate phenotype and vitamin D deficiency rickets. Due to the possible role of vitamin D deficiency in the pathogenesis of dysostosis multiplex we recommend that patients with lysosomal storage disease should be supplemented with vitamin D.

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Chromosomal Aberrations In Peripherallymphocytes Of A High-Voltage Power Linemanexposed To Electromagnetic Fields, M. Emi̇n Erdal, Nurten Erdal, Si̇bel Oğuzkan Jan 1999

Chromosomal Aberrations In Peripherallymphocytes Of A High-Voltage Power Linemanexposed To Electromagnetic Fields, M. Emi̇n Erdal, Nurten Erdal, Si̇bel Oğuzkan

Turkish Journal of Medical Sciences

No abstract provided.

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Autosomal Dominant Osteopetrosis Type Ii, Kazim Şenel, Si̇nan Sönmez, Lale Cerrahoğlu, Mahi̇r Uğur, Selami̇ Suma Jan 1999

Autosomal Dominant Osteopetrosis Type Ii, Kazim Şenel, Si̇nan Sönmez, Lale Cerrahoğlu, Mahi̇r Uğur, Selami̇ Suma

Turkish Journal of Medical Sciences

No abstract provided.

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Arginine Hydrolysis By Mycoplasma Fermentansisregulated By Glucose, Sema Aşkin Özcan Jan 1999

Arginine Hydrolysis By Mycoplasma Fermentansisregulated By Glucose, Sema Aşkin Özcan

Turkish Journal of Medical Sciences

Arginine metabolism by mycoplasmas has been reported to be correlated with pathogenicity. Since a clinically important mycoplasma; M. fermentans hydrolyses arginine as an energy source, the arginine metabolism amongst M. fermentans strains belonging to different isolation sites was investigated. Arginine hydrolysis was detected by the increase in NH 4+ concentration, measured using an NH 4+ -sensitive electrode. The method proved simple to use and gave reproducible results. In broth medium, arginine and glucose were both shown to act as energy sources for growth. It was also shown that, in contrast to previous work, glucose inhibited arginine hydrolysis during growth. There …

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In Vitro Effects Of Some Anthelminthics On Themalate Dehydrogenase And Lactate Dehydrogenaseenzyme Activities Of Taenia Saginata, A. Yasemi̇n Öztop, Gülendame Saygi, H. Nursevi̇n Öztop Jan 1999

In Vitro Effects Of Some Anthelminthics On Themalate Dehydrogenase And Lactate Dehydrogenaseenzyme Activities Of Taenia Saginata, A. Yasemi̇n Öztop, Gülendame Saygi, H. Nursevi̇n Öztop

Turkish Journal of Medical Sciences

Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 \mumol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p

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Hodgkin's Disease And Eptein-Barr Virus Infection: Phenotypical Features, Sülen Sarioğlu, Alp Kiliçalp, Aydanur Kargi Jan 1999

Hodgkin's Disease And Eptein-Barr Virus Infection: Phenotypical Features, Sülen Sarioğlu, Alp Kiliçalp, Aydanur Kargi

Turkish Journal of Medical Sciences

The purpose of this study is to investigate the presence of Epstein-Barr Virus (EBV) infection, phenotypical features and proliferative activity in Hodgkin's Disease (HD) for both the reactive and neoplastic cell populations. Sections from 4 lymphocyte predominance (LP), 13 nodular sclerosis (NS), 10 mixed cellularity (MC), total 27 HD tissue blocks were stained by avidin biotin complex method using primary antibodies against latent membrane protein-I (LMP-I), epithelial membran antigen (EMA), leukocyte common antigen (LCA), CD20, CD43, UCHL-1, S100, proliferating cell nuclear antigen (PCNA) and diaminobenzidine (DAB) was used as chromogen. Also double immunostaining was performed in 5 cases using avidin-biotin …

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