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Total And Lipid-Bound Sialic Acid Levels Inactinic Keratosis And Basal Cell Carcinoma, Pervi̇n Vural, Mukaddes Canbaz, Di̇lek Selçuki̇ Jan 1999

Total And Lipid-Bound Sialic Acid Levels Inactinic Keratosis And Basal Cell Carcinoma, Pervi̇n Vural, Mukaddes Canbaz, Di̇lek Selçuki̇

Turkish Journal of Medical Sciences

Malignant cells have more sialic acid in their cell membrane than normal cells. Many studies have shown that mean values of total sialic acid (TSA) or lipid-bound sialic acid (LSA) were higher in patients with cancer than in normal subjects. Sialic acid levels correlate with stage of disease, tumor burden, degree of metastasis and recurrence of disease. The aim of the present study was to determine the plasma TSA, LSA, total protein (TP) and TSA/TP values in basal cell carcinoma (BCC) and evaluate if they are sensitive markers for malignancy. Plasma TSA and LSA were measured according to the method …

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The Effects Of Insulin On Serum Levels Of Apo A-I Containing Lipoprotein Particles In Syndrome X Patients With Coronary Heart Disease, Meti̇n Yildirimkaya, Cumhur Kilinç, Mustafa Özkan, Kurtuluş Yilmaz, Yavuz Nari̇n Jan 1999

The Effects Of Insulin On Serum Levels Of Apo A-I Containing Lipoprotein Particles In Syndrome X Patients With Coronary Heart Disease, Meti̇n Yildirimkaya, Cumhur Kilinç, Mustafa Özkan, Kurtuluş Yilmaz, Yavuz Nari̇n

Turkish Journal of Medical Sciences

Syndrome X consists of low serum high density lipoprotein-cholesterol (HDL-C), raised serum triglyceride, glucose intolerance, increased blood pressure, abdominal obesity and insulin resistance which is associated with increased risk of coronary heart disease (CHD). Apolipoprotein (apo) A-I containing lipoprotein particles, lipoprotein A-I (Lp A-I) and lipoprotein A-I:A-II (Lp A-I:A-II.) may have different metabolic functions. The purpose of this study was to evaluate the relationship between insulin and apo A-I containing lipoproteins in syndrome X patients with or without CHD. We selected 38 male patients with syndrome X and divided into two groups: The one with CHD (n=21) and the other …

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Troponin T In The Evaluation Of Prognosis Inpatients With Unstable Angina, Ali̇ Ekeci̇k, Ali̇ Ergi̇n, Kutay Taşdemi̇r, Meral Aşçioğlu Jan 1999

Troponin T In The Evaluation Of Prognosis Inpatients With Unstable Angina, Ali̇ Ekeci̇k, Ali̇ Ergi̇n, Kutay Taşdemi̇r, Meral Aşçioğlu

Turkish Journal of Medical Sciences

Cardiac troponin T (TnT) is a regulatory contractile protein not normally found in blood. Minor elevations of TnT in patients with unstable angina have been associated with an increased risk of subsequent death or Acute Myocardial Infarction (AMI). We used a neewly developed enzyme immunoassay for TnT to determine whether its presence in the serum of patients with unstable angina was a prognostic indicator. We screened 105 hatients with unstable angina (23 with accelerated or subacute angina and, 82 with acute angina at rest) for TnT every eight hours for two days after admission to the hospital. The outcomes of …

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Meta-Analysis Of Quality Of Life Constructs In Antihypertansive Drug Theraphies, Mehtap Akçi̇l, Ergun Karaağaoğlu Jan 1999

Meta-Analysis Of Quality Of Life Constructs In Antihypertansive Drug Theraphies, Mehtap Akçi̇l, Ergun Karaağaoğlu

Turkish Journal of Medical Sciences

Objectives : It is usually accepted that some of the treatments affect not only the survival times but as well the quality of life of patients. The aim of study is to reach more reliable conclusions by using the meta-analysis method on published studies which deal with the effects of antihypertansive theraphies on the quality of life of patients. Material and Methods : Meta-analysis is used to combine the results of different experiments or studies examining the same question. Meta-analysis is a systematic reviewing strategy for adressing research question that is especially useful when results from several studies disagree with …

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Accuracy Of Sphygmomanometers, Okay Başak, Şebnem Karazeybek Jan 1999

Accuracy Of Sphygmomanometers, Okay Başak, Şebnem Karazeybek

Turkish Journal of Medical Sciences

One of the factors affecting the accuracy of readings of blood pressure is the equipment used. Defects or inaccuracy of aneroid sphygmomanometers may be source of error in blood pressure measurement. We inspected 100 sphygmomanometers for physical defects and assessed their accuracy against a standard mercury manometer at four different pressure points. 46 of the 100 sphygmomanometers were determined to be intolerant (deviation from the mercury manometer by greater than±3 mm Hg at two or more of the test points). There were faults in the inflation-deflation system of 34 sphygmomanometers. The most common physical defects were: defective pump bulb, defective …

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Very Late Relapse In Hodgkin's Disease, İmdat Di̇lek, Günhan Gürman, Işinsu Kuzu, Seli̇m Erekul Jan 1999

Very Late Relapse In Hodgkin's Disease, İmdat Di̇lek, Günhan Gürman, Işinsu Kuzu, Seli̇m Erekul

Turkish Journal of Medical Sciences

No abstract provided.

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Transfection Of Human Kidney Epithelial 293cells With Bacterial Cytosine-5-Methyltransferasem. Msp1 And The Sv40 Nuclear Localisationsequence Of Vp1, Öztürk Özdemi̇r Jan 1999

Transfection Of Human Kidney Epithelial 293cells With Bacterial Cytosine-5-Methyltransferasem. Msp1 And The Sv40 Nuclear Localisationsequence Of Vp1, Öztürk Özdemi̇r

Turkish Journal of Medical Sciences

The aim of this study was to con-struct a plasmid that would direct the expres-sion of a bacterial DNA methyltransferase in cultured mammalian cells. It was carried out with a PCR-based strategy for introducing three components' coding sequences into the transfection vector pcDNA 3 (Invitrogen). The gene encoding the bacterial cytosine specific DNA methyltransferase M. Msp1 was first introduced into the general cloning vector pMTL23. Then, the coding sequence for glu-tathione- S-transferase was added into the upstream of human viral nuclear localisation sequences SV40 VPI of the prepared con-struct using the PCR technique. The complete synthetic fusion protein gene was …

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Characterization Of Catalytic Phenotype Of \Beta-Galactosidasefrom Laci Mutant, E. Coli Csh-36,As A Tool For The Management Of Lactoseintolerance, Ayşegül Ayyildiz Jan 1999

Characterization Of Catalytic Phenotype Of \Beta-Galactosidasefrom Laci Mutant, E. Coli Csh-36,As A Tool For The Management Of Lactoseintolerance, Ayşegül Ayyildiz

Turkish Journal of Medical Sciences

Objectives: Lactose intolerance is a common public health problem with 5-100% prevalance among different populations of the world. Use of \beta-galactosidase to reduce the lactose content in food or consumption of special products of milk or exogeneous lactase enzyme are among the approaches taken to manage lactose intolerance. Recombinant \beta -galactosidase as well as \beta -galactosidase derived from different sources have variances in their bioefficiency. Thermodynamic properties of \beta -galactosidase determines the industrial efficiency. In this \beta -galactosidase from E. coli CSH-36, a constitutive expressor of enzyme was investigated for enzyme biofunctionality. Methods: The enzyme was purified by cell lysis, …

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The Intracellular Concentration Of Components Ofthe Ubiquitin System In A549 Culture Cellsduring Uv Treatment, İbrahi̇m Pi̇ri̇m Jan 1999

The Intracellular Concentration Of Components Ofthe Ubiquitin System In A549 Culture Cellsduring Uv Treatment, İbrahi̇m Pi̇ri̇m

Turkish Journal of Medical Sciences

This study attempts to determine a link between the intracellular components of the ubiquitin (Ub) system and the process of DNA repair in eukaryotes. It is possible to investigate this link in two ways: i. studying the concentration of mRNA for specific Ub components in DNA damaged and controlled cells. ii. studying the concentration of proteins of the Ub system in both DNA damaged and control cells. The specific aim of this study was to try to establish such a link between repair and Ub, by studying and making a quantitative analysis of the intracellular concentrations of both the Ub …

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The Protective Effect Of Vitaminse And C On The Gastric Mucosal Barrier In Ratsirradiated With X-Rays, Ci̇hat Güzel, Cemi̇l Sert, Zeki̇ Kanay, Doğan Kurt Jan 1999

The Protective Effect Of Vitaminse And C On The Gastric Mucosal Barrier In Ratsirradiated With X-Rays, Ci̇hat Güzel, Cemi̇l Sert, Zeki̇ Kanay, Doğan Kurt

Turkish Journal of Medical Sciences

The protective effect of vitamins E and C on the gastric mucosal barrier in rats irradiated with X-rays was investigated. Thirty-two male Wistar Albino rats were used. The animals were divided into four groups and arranged of follows: the first group (n=8) was the sham group; the second group (n=8) was the control group which was irradiated with X-rays, the third group (n=8) to which vitamin C was administered and the fourth group (n=8) to which vitamin E was given. The animals in the groups except the sham group wereirradiated with 8.9 Gy X-rays. Twenty-four hours later, the animals were …

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A Combined Variation In The Gluteal Region, Zeli̇ha Kurtoğlu, M. Haluk Uluutku Jan 1999

A Combined Variation In The Gluteal Region, Zeli̇ha Kurtoğlu, M. Haluk Uluutku

Turkish Journal of Medical Sciences

No abstract provided.

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Marfan Syndrome With Bicuspid Aortic Valvediagnosed By Transesophageal Echocardiography, Fati̇h Yalçin, İrfan Sabah Jan 1999

Marfan Syndrome With Bicuspid Aortic Valvediagnosed By Transesophageal Echocardiography, Fati̇h Yalçin, İrfan Sabah

Turkish Journal of Medical Sciences

No abstract provided.

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Hepatic Macronodular Tuberculosis, İlgi̇nç Yorulmaz, Hakan Uncu, Yalçin Aker, Aslan Sakarya, Aydin Isisag Jan 1999

Hepatic Macronodular Tuberculosis, İlgi̇nç Yorulmaz, Hakan Uncu, Yalçin Aker, Aslan Sakarya, Aydin Isisag

Turkish Journal of Medical Sciences

No abstract provided.

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Vancomycin-Induced Lupus Erythematosuslikereaction, İfti̇har Köksal, Kemaletti̇n Aydin, Rahmet Çaylan, Sevi̇m Aydin, Yavuz Özoran, Abdülkadi̇r Rei̇s, Gülseren Çi̇mşi̇t Jan 1999

Vancomycin-Induced Lupus Erythematosuslikereaction, İfti̇har Köksal, Kemaletti̇n Aydin, Rahmet Çaylan, Sevi̇m Aydin, Yavuz Özoran, Abdülkadi̇r Rei̇s, Gülseren Çi̇mşi̇t

Turkish Journal of Medical Sciences

No abstract provided.

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Proximal Rectal Stenosis, Mehmet Demi̇rcan, M. Harun Gürsoy, Sema Uğuralp, Mustafa Aydinç, Murat Mutuş Jan 1999

Proximal Rectal Stenosis, Mehmet Demi̇rcan, M. Harun Gürsoy, Sema Uğuralp, Mustafa Aydinç, Murat Mutuş

Turkish Journal of Medical Sciences

No abstract provided.

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Non-Gestational Impetigo Herpetiformis, Teoman Erdem, Ali̇ Karakuzu, Muammer Parlak, Necmetti̇n Akdeni̇z Jan 1999

Non-Gestational Impetigo Herpetiformis, Teoman Erdem, Ali̇ Karakuzu, Muammer Parlak, Necmetti̇n Akdeni̇z

Turkish Journal of Medical Sciences

No abstract provided.

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S-Aroylmethyl N, N-Disubstituteddithiocarbamates With Antiparkinson Activity, Rahi̇me Şi̇mşek, Ci̇hat Şafak, Kevser Erol, Kami̇l Vural Jan 1999

S-Aroylmethyl N, N-Disubstituteddithiocarbamates With Antiparkinson Activity, Rahi̇me Şi̇mşek, Ci̇hat Şafak, Kevser Erol, Kami̇l Vural

Turkish Journal of Medical Sciences

Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

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An Immunohistochemical Study Of Gastricneuroendocrine Tumors: Expression Ofproliferating Cell Nuclear Antigen Andp53 Oncoprotein, Gülen Doğusoy, Süha Göksel, Işil Paki̇ş, Haydar Durak, Gökhan Ersoy, Selda Göçener Jan 1999

An Immunohistochemical Study Of Gastricneuroendocrine Tumors: Expression Ofproliferating Cell Nuclear Antigen Andp53 Oncoprotein, Gülen Doğusoy, Süha Göksel, Işil Paki̇ş, Haydar Durak, Gökhan Ersoy, Selda Göçener

Turkish Journal of Medical Sciences

The aim of this study is to examine expression of Proliferating cell nuclear antigen (PCNA) and p53 oncoprotein in gastric neuroendocrine tumors. 35 gastric neuroendocrine tumors were analyzed for first histopathologic features and then, immunohistochemical study was done to detect labeling index of PCNA and accumulation of p53 protein by using monoclonal antibodies and the Labeled strepavidin-biotin method. PCNA labeling index and p53 protein expression were compared with histopatholoic features in statistical methods of Fisher's exact, chi square and logistic regression tests. No significant correlation was found between them except PCNA score and depth of invasion. In conclusion, our findings …

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Effect Of Etidronate On Urinary Calcium/Creatinin Ratio In Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study, Şenol Küçük, Remzi̇ Gökdeni̇z, Ruşen Atmaca, İsmai̇l Uryan, Ali̇ Buhur, Ömür Taşkin Jan 1999

Effect Of Etidronate On Urinary Calcium/Creatinin Ratio In Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study, Şenol Küçük, Remzi̇ Gökdeni̇z, Ruşen Atmaca, İsmai̇l Uryan, Ali̇ Buhur, Ömür Taşkin

Turkish Journal of Medical Sciences

There are both histomorphometric and nonhistomorphometric studies confirming that etidronate reduces bone resorption. In this study, we have examined urinary Calcium/Creatinine ratio (uCA/Cr) as a biochemical marker of bone turnover to show the effectiveness of etidronate and whether it could be used as a follow-up parameter of treatment. Eighty-one postmenopausal women aged 40 to 65 included into the study to investigate the effects of etidronate on uCa/Cr in a prospective, randomised, placebo controlled clinical trial. All necessary criteria matched 81 women were divided into 3 groups at random, each group consisted of 27 patients. Prior to treatment, uCa/Cr was calculated …

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Urinary Serotonin And 5-Hydroxyindolacetic Acid Levels In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz, Alkan Yildirim Jan 1999

Urinary Serotonin And 5-Hydroxyindolacetic Acid Levels In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz, Alkan Yildirim

Turkish Journal of Medical Sciences

The role of serotonin in the pathogenesis of hypertension which is one of the main symptoms of preeclampsia is of growing importance. The levels of serotonin (5-Hydroxytryptamin or 5-HT) and its metabolite, 5-Hydroxyindolacetic acid (5-HIAA) in twenty-four hour urine samples taken from severe preeclamptic and normotensive pregnant women were determined by colon chromotography and spectrophotometry. In preeclamptic pregnant women there was a significant increase in 5-HT levels (P

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The Dermatophytic Flora Ratio Of Dermatophytes, Hüseyi̇n Taniş, Gürbüz Aksoy, Zülal Aşçi Jan 1999

The Dermatophytic Flora Ratio Of Dermatophytes, Hüseyi̇n Taniş, Gürbüz Aksoy, Zülal Aşçi

Turkish Journal of Medical Sciences

This paper describes the mycological examination of patients admitted to the department of dermatology of Kahramanmaras State Hospital. One hundred and seventy samples of finger nails, hairs and skin were collected from patients suspected of having fungal diseases and were examined under a light microscope after being treated with 15-20% KOH solution. It was observed that 68 of the 170 samples contained fungal hyphae and arthrospores, while 62 samples were free of these. Forty samples were observed to have Malasezia furfur. The samples containing M. furfur were not subjected to a culture medium. Of the 130 cultured samples, 68 had …

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Focal Dermal Hypoplasia (Goltz Syndrome) In Amale Infant, Hülya Bi̇lgen, Eren Özek, Cengi̇z Canpolat, Oya Gürbüz, Müyesser Tuncer Jan 1999

Focal Dermal Hypoplasia (Goltz Syndrome) In Amale Infant, Hülya Bi̇lgen, Eren Özek, Cengi̇z Canpolat, Oya Gürbüz, Müyesser Tuncer

Turkish Journal of Medical Sciences

No abstract provided.

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Prevalence Of Diabetic Nephropathy In Turkish Children With Insulin-Dependent Diabetes Mellitus, Ayşenur Ökten, Gülay Kaya, Gülay Karagüzel, Yusuf Gedi̇k, Muhterem Özdemi̇r Jan 1999

Prevalence Of Diabetic Nephropathy In Turkish Children With Insulin-Dependent Diabetes Mellitus, Ayşenur Ökten, Gülay Kaya, Gülay Karagüzel, Yusuf Gedi̇k, Muhterem Özdemi̇r

Turkish Journal of Medical Sciences

This study was involved with determining the prevalence of diabetic nephropathy in 72 Turkish children with insulin-Dependent diabetes mellitus. Diabetic nephropathy was diagnosed with blood pressure levels, glomerular filtration rate, albumin excretion rate, ?-2 microglobulinuria and kidney length. There wereo significant differences between laboratory data for boys and girls, but adolescent patients had significantly higher albumin excretion rates than preadolescent patients (p

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Effects Of Surgical Trauma On Articular Cartilage, Di̇lek Taşkiran, Emi̇n Taşkiran, Hakan Özsoy, Veli̇ Lök Jan 1999

Effects Of Surgical Trauma On Articular Cartilage, Di̇lek Taşkiran, Emi̇n Taşkiran, Hakan Özsoy, Veli̇ Lök

Turkish Journal of Medical Sciences

This study was designed to evaulate the effects of reconstruction of anterior cruciate ligament on cartilage collagen and proteoglycan metabolism. Proteoglycan fragments (PF) and matrix metalloproteinase-1 (MMP-1) levels were assessed in synovial fluids aspirated from 17 patients preoperatively and at 1 st month postoperatively. Synovial fluids of 10 healthy knee served as controls. Both MMP-1 and proteoglycan fragments were found significantly elevated in pathological knees preoperatively with compare to control. The postoperative levels of MMP-1 and proteoglycans were also significantly higher than preoperative and control values. These findings suggest that surgical trauma may have detrimental effects on cartilage matrix metabolism …

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Diurnal Variation Of Methotrexatepharmacokinetics In Adults With Osteosarcoma, Necdet Soykan, Mehtap Çinar, Cenk Can, Banu Çiçek Bi̇lkay Jan 1999

Diurnal Variation Of Methotrexatepharmacokinetics In Adults With Osteosarcoma, Necdet Soykan, Mehtap Çinar, Cenk Can, Banu Çiçek Bi̇lkay

Turkish Journal of Medical Sciences

The daytime and nighttime dispositions of high dose (12 g/m 2 ) methotrexate were examined in 8 osteosarcoma patients. The plasma and renal clearances, urine pH values and area under the curves were compared. The plasma clearance of methotrexate tended to fall after it was administered at (from 1.74±0.06 ml/min/kg to 0.47±0.01 ml/min/kg, p

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Interictal Spect With Tc 99m-Hm Pao In Migrainepatients, Meral Mi̇rza, Ahmet Tutuş, Füsun Erdogan, Mustafa Kula, Ali Tomar, Güler Silov, Emel Köseoğlu Jan 1999

Interictal Spect With Tc 99m-Hm Pao In Migrainepatients, Meral Mi̇rza, Ahmet Tutuş, Füsun Erdogan, Mustafa Kula, Ali Tomar, Güler Silov, Emel Köseoğlu

Turkish Journal of Medical Sciences

Migraine is considered to be a functional neurological disorder. For several years cerebral blood flow studies have been fueling the controversy surrounding the pathophysiology of migraine headache. Tc 99m-HM PAO SPECT brain imaging was performed during the headache-free period of 29 migraine sufferers (24 without aura, 5 with aura). The findings were compared with those of an age-and sex-matched control group of 17 people. The SPECT images revealed clear interhemispheric asymmetry in the right frontal, temporal and occipital lobes of the brain in the study group. Slight hypoperfusion was observed in patients who had interictal EEG abnormalities.

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Effect Of Psychological Stress On Nasal Immunity, Erdal Seren, Abdülcemal Ümit Işik, Mehmet İmamoglu, Osman Bahadir, Mehmet Arif Köroğlu, Yavuz Tekeli̇oğlu Jan 1999

Effect Of Psychological Stress On Nasal Immunity, Erdal Seren, Abdülcemal Ümit Işik, Mehmet İmamoglu, Osman Bahadir, Mehmet Arif Köroğlu, Yavuz Tekeli̇oğlu

Turkish Journal of Medical Sciences

Stress activates the hypotalamic-pituitary- adrenal axis, increases circulating glucocorticoids, and is associated with alterations in immune functions. Nasal mucosa is richly innervated by sympathetic nerve fiber and nasal patency changes in response to various sympathetic stimuli. These fibres form close neuroeffector junctions with lymphocytes and macrophages. Nasal lavage and peripheral blood samples were collected from healthy medical students one hour before their exams and a week later, after the declaration of results of the exams were announced. We determined and compared the distribution of T lymphocyte subsets in students under psychological stress The T cell: natural killer cell, T helper …

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The Assessment Of Anthropometrical Measurements Of Newborns And The Incidence Of Fetal Malnutrition In Erzurum Region, Zerrin Orbak, Hüseyin Tan, Nevin Sağsöz, Fatih Zor Jan 1999

The Assessment Of Anthropometrical Measurements Of Newborns And The Incidence Of Fetal Malnutrition In Erzurum Region, Zerrin Orbak, Hüseyin Tan, Nevin Sağsöz, Fatih Zor

Turkish Journal of Medical Sciences

We included in this study 1100 newborns whose gestational ages were between 26 and 42 weeks. Of these infants, 323(29.4%) were preterm. The others 777(70.6%) were term infants. In term newborns, the mean weight, length, head circumference and ponderal indexes of males were significantly higher than those of females (p

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Nosocomial Urinary Tract Infections In Children, Ayse Balat, L. Leighton Hill Jan 1999

Nosocomial Urinary Tract Infections In Children, Ayse Balat, L. Leighton Hill

Turkish Journal of Medical Sciences

Nosocomial infections are a major cause of morbidity and mortality in hospitalized children, and the urinary tract is one of the most common sites of these infections. We retrospectively reviewed the charts of 1,221 children discharged with a diagnosis of urinary tract infection (UTI) from July 1, 1991 to June 30, 1994. Of the 1,221 UTIs, there were 137 (11.2%) cases of nosocomial UTI (NUTI) in 136 patients. NUTI accounted for 0.28% of all discharges (48, 382 patients) at a single institution over the 3-year period studied. There were 75 girls and 61 boys. The mean age was 4.4 years …

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Conjugated Bilirubin Measurement Re-Examined: A New 'Approach'., Aidan Kelleher Jan 1999

Conjugated Bilirubin Measurement Re-Examined: A New 'Approach'., Aidan Kelleher

Theses

Conjugated bilirubin is an important but difficult metabolite to measure accurately, elevated levels of conjugated bilirubin in the serum are indicative of obstructive jaundice and therefore can be used to discriminate this disorder from other forms of unconjugated hyper bilirubinaemia.

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