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Articles 43831 - 43860 of 45215
Full-Text Articles in Entire DC Network
Effects Of Glycation On Erythrocyte Carbonicanhydrase-I And Ii In Patients With Diabetesmellitus, Hasan Özdemi̇r, Ömer İrfan Küfrevi̇oğlu, Ramazan Çeti̇nkaya
Effects Of Glycation On Erythrocyte Carbonicanhydrase-I And Ii In Patients With Diabetesmellitus, Hasan Özdemi̇r, Ömer İrfan Küfrevi̇oğlu, Ramazan Çeti̇nkaya
Turkish Journal of Medical Sciences
In order to investigate the effect of high blood glucose levels of long duration on carbonic anhydrase, and to evaluate the relation of the enzyme to its inhibitors in uncontrolled Type 1 diabetic patients, erythrocyte CA -I and CA-II activities and their kinetic parameters were determined. The effects of glycation on erythrocyte carbonic anhydrase-I and II (CA-I and CA-II) in patients with Type-I diabetes mellitus (uncontrolled) were investigated using kinetic parameters. After blood glucose and hemolysate total esterase activity levels had been measured in both 10 control and 10 diabetic subjects, CA-I and CA-II in hemolysate were purified separately by …
The Importance Of Fibronectin, Haptoglobin,Ceruloplasmin And Transferrin In The Earlydiagnosis Of Neonatal Sepsis, Ayhan Gazi̇ Kalayci, Fazli Yilmazer, Bahatti̇n Adam, Recep Sancak, Şükrü Küçüködük
The Importance Of Fibronectin, Haptoglobin,Ceruloplasmin And Transferrin In The Earlydiagnosis Of Neonatal Sepsis, Ayhan Gazi̇ Kalayci, Fazli Yilmazer, Bahatti̇n Adam, Recep Sancak, Şükrü Küçüködük
Turkish Journal of Medical Sciences
Serum fibronectin, haptoglobin, ceruloplasmin, and transferrin concentrations were measured in 44 term neonates with culture proven sepsis and a control group of 37 normal neonates of similar age, sex and weight. The white blood cell count, total neutrophil count, and the ratio of band to neutrophils were also determined. While the serum fibronectin and haptoglobin concentrations were significantly different (P
Recovery Of Neuromuscular Block Aftertourniquet Inflation: Comparison Of Atracuriumand Vecuronium, S. Yildirim, A. C. Şenel, G. Aktürk, İ. Özen
Recovery Of Neuromuscular Block Aftertourniquet Inflation: Comparison Of Atracuriumand Vecuronium, S. Yildirim, A. C. Şenel, G. Aktürk, İ. Özen
Turkish Journal of Medical Sciences
To determine the influence of circulatory factors on recovery from neuromuscular block, we measured train of four (TOF) response in the arm with tourniquet inflated during TOF = 0.1 and compared this with data from a control arm in 40 patients under fentanyl-propofol-nitrous oxide-isoflurane anaesthesia. Patients were allocated randomly to receive either atracurium 0.5 mg/kg (n=20) or vecuronium 0.1 mg/kg (n=20). The TOF response of ulnar nerve in both arms was recorded in every 12 sec. When neuromuscular block was 90% (TOF = 0.1), the tourniquet was inflated to a pressure of 300 mmHg, and when a neuromuscular block recovery …
The Effects Of Exercise And Smoking On Serumlecithin: Cholesterol Acyltransferase Activity Inyoung Men, Cumhur Kilinç, Zübeyr Yağmur, Kurtuluş Yilmaz, Üçler Kisa
The Effects Of Exercise And Smoking On Serumlecithin: Cholesterol Acyltransferase Activity Inyoung Men, Cumhur Kilinç, Zübeyr Yağmur, Kurtuluş Yilmaz, Üçler Kisa
Turkish Journal of Medical Sciences
Lecithin: cholesterol acyltransferase (LCAT) is an enzyme responsible for the formation of most cholesteryl esters (CE) in human serum. In this study investigating the effects of exercise and smoking on LCAT acitvity, serum triglyceride (Tg), total cholesterol (C), HDL-C, HDL3-C and LCAT activity were measured in the sera of 29 nonsmoking and 36 smoking (at least one packet/day) young men before and after their 6-week military training period. LCAT activity was determined by measuring the amount of cholesterol esters produced in the incubation of serum and reconstituted HDL including [ 14 C]-cholesterol. Tg and C were measured with enzymatic-colorimetric methods. …
Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz
Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz
Turkish Journal of Medical Sciences
This study was conducted to examine the autonomic nervous system functions of obese people. The study group consisted of 30 healthy obese people (20 female, 10 male, age range 18-58, median 37.6±9.7 years of age) and the control group consisted of 30 healthy nonobese people (18 female, 12 male, age range 17- 56, median 34.4±7.5 years). Each function was tested by non-invasive applications (orthostatic test, isometric exercise test, Valsalva ratio test, 30/15 ratio test, heart rate change test by deep respiration). The results of the orthostatic test and isometric- exercise test yielded a statistically significant difference between the study and …
Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen
Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen
Turkish Journal of Medical Sciences
The purpose of this study was to determine normal liver and spleen size variations in school-age children by US. Sonographic measurements were taken with an age and sex stratified random sample of 358 healthy children (188 boys, 170 girls) between the ages of 7 and 12 years. The weight and height of the children were assessed and then the body surface area (BSA) of each child was calculated. The size of the liver was measured in two different planes: the subcostal sagittal (L1), and subcostal semiaxial (L2). Spleen size was measured through a coronal view that included the hilum (S1) …
Isoniazid Poisoning With Seizures, Shoulderdislocation, And Fracture Of The Greatertuberosity, Yüksel Gökel, Sali̇m Satar, Mehmet Duru, Zi̇kret Köseoğlu, Güven Kuvandik
Isoniazid Poisoning With Seizures, Shoulderdislocation, And Fracture Of The Greatertuberosity, Yüksel Gökel, Sali̇m Satar, Mehmet Duru, Zi̇kret Köseoğlu, Güven Kuvandik
Turkish Journal of Medical Sciences
No abstract provided.
Acute Dynamic Exercise Reduces Intraocularpressure, İbrahi̇m Koçer, Şenol Dane
Acute Dynamic Exercise Reduces Intraocularpressure, İbrahi̇m Koçer, Şenol Dane
Turkish Journal of Medical Sciences
No abstract provided.
The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin
The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin
Turkish Journal of Medical Sciences
Human cells that live in biological harmony can become cancerous. As they do so, they engage in anaerobic respiration, undergo rapid cell growth and division according to nonmitotic rules, and important changes take place in their metabolism. We conducted several investigations in an effort to block or change the metabolic characteristics of cancer cells using a typical cancerous cell line. Specifically,we investigated the effects of sodium selenite (Na_2 SeO_ 3 ) on antioxidant enzyme activities and reduced glutathione levels in Hepatoma G_ 2 cells, cells that show rapid glutamine uptake and metabolism. A Hepatoma G_ 2 cell line was cultured …
Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan
Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan
Turkish Journal of Medical Sciences
Bacterial translocation is an important etiologic factor in multisystem organ failure and sepsis, which have a high mortality rate. To determine the effects of growth hormone on bacterial translocation, an experimental study was performed. Twenty pathogen-free rabbits were divided into two groups each containing 10 rabbits. After loop obstruction was performed, the rabbits in the control group were given saline solution whereas the rabbits in the study group received growth hormone. Relaparotomy was performed after 24 hours, and tissue and blood samples were collected for histopathologic and microbiologic examinations. Bacterial translocation rates were higher in the control group than in …
Nimodipine Aggravates Systemic Kainic Acid Toxicity In Retinal Ganglion Cells Of Intact Mice, Akçahan Gepdi̇remen, Murat Kaya, İbrahi̇m Koçer, Cemal Gündoğdu
Nimodipine Aggravates Systemic Kainic Acid Toxicity In Retinal Ganglion Cells Of Intact Mice, Akçahan Gepdi̇remen, Murat Kaya, İbrahi̇m Koçer, Cemal Gündoğdu
Turkish Journal of Medical Sciences
The aim of the present study was to investigate the role of the L-type voltage dependent Ca^2^+ channel blocker, nimodipine, in kainate induced toxicity in retinal ganglion cells of mice. Kainate in 10mg/kg was administered intraperitoneally following the vehicle or nimodipine. Nimodipine, 45 minutes prior to kainate in 10, 15, 25, 50, 100 and 250 mg/kg doses was administered intraperitoneally. Surprisingly, nimodipine potentiated the ganglional cell death induced by kainate, with respect to the control and kainate+vehicle treated group. In accordance with our results, blockage of L-type calcium channels by nimodipine may worsen the prognosis and survival of retinal neurons …
Quantitation Of Neuronal Loss Induced By Status Epilepticus And The Effects Of Nitric Oxide, Güldal Güleç, Behzat Noyan
Quantitation Of Neuronal Loss Induced By Status Epilepticus And The Effects Of Nitric Oxide, Güldal Güleç, Behzat Noyan
Turkish Journal of Medical Sciences
Neuronal loss in the hippocampal CA1 and CA3 fields due to lithium-pilocarpine- induced status epilepticus (SE) and the effects of a nitric oxide (NO) substrate, L-Arginine and a NO synthase inhibitor, N_w -nitro-L-Arginine methyl ester (L-NAME) on SE-induced brain damage were determined using the neuron counting procedure in rats. Rats were implanted with four chronic, epidural screw electrodes in order to obtain electrocortical recordings. SE was determined from the electrocortical recordings. After decapitation, the brains were removed, and the hippocampal sections were obtained and stained with hematoxylin and eosin. An analysis of variance (ANOVA) and Student's t- test were used …
Biomimetic Preparation Of Ha Powders At 37°C In Urea-And Enzyme Urease-Containing Synthetic Body Fluids, Defne Bayraktar, A. Cüneyt Taş
Biomimetic Preparation Of Ha Powders At 37°C In Urea-And Enzyme Urease-Containing Synthetic Body Fluids, Defne Bayraktar, A. Cüneyt Taş
Turkish Journal of Medical Sciences
An important inorganic phase of synthetic bone applications, calcium hydroxyapatite (HA, Ca_10 (PO_ 4 ) 6_(OH_2 ), was prepared as a single-phase and sub-micron bioceramic powder. Carbonated HA powders were synthesized from calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate salts dissolved in synthetic body fluid (SBF) solutions, containing urea (H_2 NCONH_2 ) and enzyme urease, under the biomimetic conditions of 37°C and pH 7.4, with a novel chemical precipitation technique. These powders were also found to contain trace amounts of Na and Mg ions in them, intentionally incorporated by using SBF solutions, instead of pure water, during their synthesis. The …
The Use Of A Nonradioactive Digoxigenin Labeled Probe For Detection Of Apo(A) Gene Size, Yeşi̇m İlçöl, Bülent İlçöl, Yavuz Taga
The Use Of A Nonradioactive Digoxigenin Labeled Probe For Detection Of Apo(A) Gene Size, Yeşi̇m İlçöl, Bülent İlçöl, Yavuz Taga
Turkish Journal of Medical Sciences
Elevated lipoprotein(a) [Lp(a)] concentrations are associated with premature coronary heart disease and early myocardial infarction. In the general human population the sizes of apolipoprotein [apo(a)] isoforms are inversely associated with lipoprotein(a) levels. Large isoforms are associated with low Lp (a) and small isoforms with high Lp(a) in the plasma. The size of the polymophism is directly correlated with the number of kringle-4 domains in apo(a). It has been shown by quantitative Southern blotting, and more recently by pulsed-field gel electrophoresis, that polymophism is the result of differences in the number of tandem kringle-4 repeats in the apo(a) gene. In our …
Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak
Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak
Turkish Journal of Medical Sciences
Fragile-X syndrome is a hereditary dynamic mutation disorder, predominantly caused by a large expansion of CGG trinucleotide repeats in the FMR 1 gene leading to methylation and down regulation of transcription of the gene. For the molecular diagnosis of the disease, the repeat locus in FMR 1 gene is primarily detected by Southern blotting with radioactively labeled probes. Unusually GC rich composition of the expanded region caused technical difficulties during PCR based testing and therefore is not performed by most diagnostic laboratories. We established a Southern blot method and a novel PCR protocol which enables the amplification of normal, premutated …
Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel
Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel
Turkish Journal of Medical Sciences
This is a preliminary study carried out on the adult population of the Sivas region. The aim was to determine the incidence of Cavum Septum Pellucidum (CSP), Cavum Vergae (CV) and Cavum Velum Interpositi (CVI) and to compare the results with the data of previous studies and the relevant literature. A total of 442 computed tomography (CT) scans (302 males, 140 females), in axial plane, from the archive of the Department of Neurosurgery at Cumhuriyet University were examined to find out the brain midline cavities. Among the 442 CT scans, 69 (15.61%) had these brain midline cavities. Out of these …
The Role Of Immunological Factors In Wound Infections (A Prospective Clinical Study), Nusret Akyürek, Mustafa Kerek, Osman Yüksel, Türkan Patiroğlu
The Role Of Immunological Factors In Wound Infections (A Prospective Clinical Study), Nusret Akyürek, Mustafa Kerek, Osman Yüksel, Türkan Patiroğlu
Turkish Journal of Medical Sciences
Wound infections are among the major problems complicating surgical procedures. The aim of this study was to investigate the relationship between the immunological status of the patient and wound infections. Wounds were classified as clean, clean-contaminated, contaminated and dirty. T-lymphocyte(CD3+), B-lymphocyte (CD19+) and total lymphocyte(CD45+) counts, and IgG, IgM, IgA levels were measured at the beginning of treatment, and on the fifth and tenth days. The levels of CD3+, CD19+, CD45+, IgGM, IgA were not different in the groups, while in the dirty group, IgG levels were lower than in the other groups, at the beginning of treatment (P0.05). There …
Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu
Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu
Turkish Journal of Medical Sciences
Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p
Prevalence Of Goitre And Its Relationship With Iodine Deficiency In School Children In Kocaeli, Turkey, Şükrü Hatun, Sidika Beykal, Yenal Dündar, Olcay Evli̇yaoğlu
Prevalence Of Goitre And Its Relationship With Iodine Deficiency In School Children In Kocaeli, Turkey, Şükrü Hatun, Sidika Beykal, Yenal Dündar, Olcay Evli̇yaoğlu
Turkish Journal of Medical Sciences
Prevalence of Goitre and Its Relationship with Iodine Deficiency in School Children in Kocaeli, Turkey 5564 primary school children living in Kocaeli, Turkey, were clinically assessed for thyroid gland enlargement. Goitre was graded according to the WHO 1994 classification. 792 children showed various grades of goitre, giving a prevalence of overall goitre of 14.23%. The median urinary iodine values were found to be greater than 10mg/dl in each group of 20 students, who were selected randomly from those in whom Grade I and Grade II goitre had been detected and from those in whom goitre had not been detected. These …
Serum Antiotensin Converting Enzyme Activity In Streptozotocin-Induced Diabetic Rats, Mustafa Vakur Bor, Esra Seval Elmali, Ni̇lgün Altan
Serum Antiotensin Converting Enzyme Activity In Streptozotocin-Induced Diabetic Rats, Mustafa Vakur Bor, Esra Seval Elmali, Ni̇lgün Altan
Turkish Journal of Medical Sciences
No abstract provided.
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Turkish Journal of Medical Sciences
Sulphydryl-containing captopril (CPR) appears to act as a scavanger of oxygen derived free radicals. This is not present in other angiotensin-converting enzymes such as enalapril (EPR). The hepatotoxic effect of carbon tetrachloride (CCl4) may result from induction of reactive oxygen free radicals. The aim of this study was to analyse the effects of CPR and non- sulphydryl-containing enalapril (EPR) in healthy rats and in rats with CCL4-induced toxic hepatitis. The rats were divided into two major groups. The first group consisted of healthy rats, and the second group consisted of rats with CCl4- induced toxic hepatitis. Each major group was …
Lineage-Restricted Function Of Nuclear Factor Kappab-Inducing Kinase (Nik) In Transducing Signals Via Cd40., Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuko Honjo, Randolph J. Noelle
Lineage-Restricted Function Of Nuclear Factor Kappab-Inducing Kinase (Nik) In Transducing Signals Via Cd40., Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuko Honjo, Randolph J. Noelle
Dartmouth Scholarship
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Turkish Journal of Medical Sciences
We have analyzed telomeres in four hamster cell lines to investigate how telomeres look in cells grown past the Hayflick limit. In all four cell lines telomeric signals were seen after detection with two different sensitive in situ methods (FISH with PNA probes and PRINS). The telomeric signals were not very strong, suggesting that the repeats are very short, but were nevertheless clearly visible. With the PRINS technique, it was further possible to probe also for the presence of variant telomeric repeats at the chromosome ends. With some of the variant repeat probes, a difference was seen between probes for …
Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin
Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin
Turkish Journal of Medical Sciences
Identification of 78 Candida isolates was carried out by a commercial Fungichrom test kit, the reliability of which was further confirmed by conventional biochemical tests and the API 20C kit. Differentiation between different Candida species was also observed when sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of whole cell proteins was used. The most frequently isolated species of yeast from vaginal swabs obtained from patients was Candida albicans, which accounted for 39 of 78 (50.00%) of the isolates from women in Ankara. The next most frequent Candida species were Candida glabrata ( Torulopsis glabrata) and Candida krusei, which were isolated …
A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n
A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n
Turkish Journal of Medical Sciences
No abstract provided.
Hvj-Liposome-Mediated Gene Transfer To Healing Rat Meniscal Tissue, İlhan Özkan, Norimasa Nakamura, Konsei Shino, Takashi Natsu-Ume, Tetsuya Tomita, Yasufumi Kaneda, Takahiro Ochi
Hvj-Liposome-Mediated Gene Transfer To Healing Rat Meniscal Tissue, İlhan Özkan, Norimasa Nakamura, Konsei Shino, Takashi Natsu-Ume, Tetsuya Tomita, Yasufumi Kaneda, Takahiro Ochi
Turkish Journal of Medical Sciences
The success rate of a repaired torn meniscus is not more than 70%. Gene transfer to healing soft tissues appears to be a feasible method for manipulating the healing process. In an attempt to evaluate the feasibility of gene transfer to meniscal tissue we tried to transfer a reporter gene ( Echerichia coli, b-galactosidase gene) by using HVJ-liposome mediated gene transfer. After performing complete radial tear on the medial meniscus of fifty 14-week-old male Wistar rats, HVJ-liposomes with DNA were injected into the femoral artery of 15 rats and into the knee joint of the other 15 rats. HVJ- liposomes …
Production And Characterization Of Monoclonal Anti-Ovalbumin Antibodies, Mehmet Zi̇ya Doymaz, Hakan Bulut, Aykut Özdarendeli̇, Yusuf Bolat
Production And Characterization Of Monoclonal Anti-Ovalbumin Antibodies, Mehmet Zi̇ya Doymaz, Hakan Bulut, Aykut Özdarendeli̇, Yusuf Bolat
Turkish Journal of Medical Sciences
In this study, the results of anti- ovalbumin (OVA) monoclonal antibody production and characterization are reported. Splenocytes from OVA-hyperimmune Balb/C mouse were fused with F0 myeloma cells and resulting hybridoma cells were selected in hypoxanthine-aminopterine-thymidine containing medium. A total of 37 HAT resistant hybridomas were obtained. Upon testing the hybridoma supernatants in OVA and mouse immunoglobulin G specific enzyme-linked immunosorbent assays, we observed that two of the hybridomas secreted OVA specific antibodies. The hybridomas produced IgG class antibodies. The hybridomas were grown and the supernatants from the cultures were also tested in a Western Blot assay. The results of ELISA …
The Radioprotective Effect Of Vitamins C, E And Vitamin E + Glutathione On The Small Intestine And The Thyroid Gland In Rats Irradiated With X- Rays, Cemi̇l Sert, M. Sali̇h Çeli̇k, Zülküf Akdağ, M. Aydin Ketani̇, Yusuf Nergi̇z
The Radioprotective Effect Of Vitamins C, E And Vitamin E + Glutathione On The Small Intestine And The Thyroid Gland In Rats Irradiated With X- Rays, Cemi̇l Sert, M. Sali̇h Çeli̇k, Zülküf Akdağ, M. Aydin Ketani̇, Yusuf Nergi̇z
Turkish Journal of Medical Sciences
This investigation was carried out in order to determine the protective effects of long term administration at supraphysiologi- cal doses of vitamin E, vitamin C and a compound of vitamin E + glutathione against damage induced by free radicals produced by ionizing radiation. Five groups of 8-10-week-old Wistar albino rats were used in the study. Group I was the sham group and Group II was the radiation group (i.e. radiation alone). The rats in Group III were given a daily dose of 400 mg/kg of vit. C for one month. The rats in Group IV were given a daily dose …
Antioxidant And Hepatoprotective Activity Of Vitamin E And Egb 761 In Experimental Endotoxemic Rats, Ömer Coşkun, Bi̇rkan Yakan, Emi̇n Öztaş, Şaban Sezen, Ali̇ A. Günaydin
Antioxidant And Hepatoprotective Activity Of Vitamin E And Egb 761 In Experimental Endotoxemic Rats, Ömer Coşkun, Bi̇rkan Yakan, Emi̇n Öztaş, Şaban Sezen, Ali̇ A. Günaydin
Turkish Journal of Medical Sciences
In this experimental study, we investigated whether vitamin E and EGb 761 have any influence on endotoxemic rats and liver histopathology. Forty rats were divided into four groups of 10 animals in each group. The control rats were untreated and comprised group 1. Two ml serum was applied to the rats intraperitoneally (i.p.) in group 2, and then 0.5 ml endotoxin solution ( E. Coli 0:157:H7, 10 9 bacteria/ml) was given to the same group two hours later. Not only endotoxin solution but also vitamin E (600 mg/kg) was given to the rats in group 3. Endotoxin solution and EGb …
Contralateral White Noise-Induced Enhancement In The Guinea Pigõs Mlr: A Possible Link To Direc- Tional Hearing, Cüneyt Göksoy, Rezzan Utkuçal
Contralateral White Noise-Induced Enhancement In The Guinea Pigõs Mlr: A Possible Link To Direc- Tional Hearing, Cüneyt Göksoy, Rezzan Utkuçal
Turkish Journal of Medical Sciences
The evoked potential components in a time window of 10-50 ms following an acoustic stimulus are called middle latency responses (MLRs). It is known that an amplitude enlargement occurs in guinea pig MLRs to monaural clicks when continuous white noise is applied to the other ear. This study was undertaken to see whether this enlargement is due simply to an overall, generalised effect of contralateral white noise (WN), or whether it may have some connection to directional hearing. Recordings were made from chronic guinea pig preparations with epidural electrodes in the temporal regions. Parallel to the results in the literature, …