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Articles 43861 - 43890 of 45214
Full-Text Articles in Entire DC Network
The Effects Of Allopurinol On Stomach Mucosal Barrier Of Rats Subjected To Ischemia-Reperfusion, Abdurrahman Önen, Zeki̇ Kanay, Ci̇hat Güzel, Doğan Kurt, Kader Ceylan
The Effects Of Allopurinol On Stomach Mucosal Barrier Of Rats Subjected To Ischemia-Reperfusion, Abdurrahman Önen, Zeki̇ Kanay, Ci̇hat Güzel, Doğan Kurt, Kader Ceylan
Turkish Journal of Medical Sciences
The present experimental study was carried out on rats subjected to ischemia and reperfusion. The effects of allopurinol on mucus, an important component of the stomach mucosal barrier, were investigated. Twenty-one Swiss Albino rats, each weighing 200-250 g, were used. On the control group, no treatment was performed, while the sham operation group was subjected to 30 minutes of ischemia and 20 minutes of reperfusion. Then, stomachs were examined for ulcerative lesions, and ulcer scores were recorded. Mucus content was determined by the Corne method. In the sham group, the mucus decreased to a significant extent (p
Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar
Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar
Turkish Journal of Medical Sciences
The protective roles of low-dose dopamine and mannitol infusion in the renal function of patients undergoing cardiovascular surgery were compared in 36 patients by measuring urine N-acetyl-\beta-D- glucosaminidase activity, serum and urinary creatinine, blood urea nitrogen (BUN) levels and urine output. The patients were randomly selected and received a continuous infusion of dopamine, 3 µg/kg/min (Group I), mannitol, 1 mg/kg/h (Group II), no medication (Group III) before the induction of anaesthesia. Urine N- acetyl-\beta-D-glucosaminidase activities, serum and urinary creatinine and BUN were determined preoperatively after aortic cross- clamping, and on the first and second postoperative days. Changes in urine N-acetyl- …
Investigation Of Various Terminal Carbohydrate Structures In Apolipoproteins Of Human Serum Chylomicrons And Vldl, Tayfun Güldür, Tülay İleri̇ Büyükoğlu, Ramazan Yilmaz
Investigation Of Various Terminal Carbohydrate Structures In Apolipoproteins Of Human Serum Chylomicrons And Vldl, Tayfun Güldür, Tülay İleri̇ Büyükoğlu, Ramazan Yilmaz
Turkish Journal of Medical Sciences
The roles of terminal carbohydrate moieties of serum glycoproteins in their recognition and uptake by receptors and in their rapid removal from the circulation are well established. However, little is known about the detailed structure of the terminal glycan chains in apolipoproteins and their compatibility with the known ligand specificity of carbohydrate recognition systems. The carbohydrate moieties of apolipoproteins in human serum chylomicrons and VLDL were examined. Chylomicrons and VLDL were isolated from the serum by ultracentrifugation for 1.6x10 ^6 g.min and 5.5x10 ^7 g.min respectively. The top 1.5cm fraction containing chylomicrons or VLDL was recovered. Following delipidization, apolipoproteins were …
Effects Of Four Different Hormone Replacement Therapy Regimens On Certain Cardiovascular Risk Factors, Erdal Malatyalioğlu, Ari̇f Kökçü, Fi̇li̇z F. Yanik, Tayfun Alper
Effects Of Four Different Hormone Replacement Therapy Regimens On Certain Cardiovascular Risk Factors, Erdal Malatyalioğlu, Ari̇f Kökçü, Fi̇li̇z F. Yanik, Tayfun Alper
Turkish Journal of Medical Sciences
This study was performed to compare the effects of 4 different hormone replacement therapy (HRT) protocols on certain cardiovascular risk factors. Eighty- nine postmenopausal women were treated with oral conjugated estrogens, transdermal 17 beta-E2, cyclic oral E2-17- valerate+cyproterone acetate (E2-17-V+CA) or tibolone. Blood pressure (BP) measurements, fasting blood glucose (FBG), serum total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride levels at the 12th month were compared with the pretreatment values in each treatment group. There were no significant changes in the systolic BP, FBG, serum total and LDL-cholesterol levels in any group. Diastolic BP …
Role Of End-Tidal Co_2 Monitoring In Patients Intubated And Resuscitated In The Emergency Department, Özgür Karcioğlu, Yasemi̇n Karcioğlu
Role Of End-Tidal Co_2 Monitoring In Patients Intubated And Resuscitated In The Emergency Department, Özgür Karcioğlu, Yasemi̇n Karcioğlu
Turkish Journal of Medical Sciences
Objective: We examined the reliability of end-tidal CO_2 (ETCO_2 ) level in predicting mortality after endotracheal intubation in emergency situations. Methods: In this prospective study, the reliability of ETCO_2 monitoring in the emergency setting as a useful predictor of outcome was investigated in 36 adult patients with pending cardiopulmonary collapse. The cardiopulmonary resuscitation (CPR) procedure was performed as usual and the cardiac rhythm, arterial O_2 saturation, non- invasive blood pressure and ETCO_2 levels were continuously monitored in all the patients. Results: Patients with an ETCO_2 concentration below 0.5% had significantly lower rates of survival. The sensitivity and specificity values of …
Auditory Brain Stem Response Screening For Hearing Loss In High Risk Neonates, Hülya Bi̇lgen, İpek Akman, Eren Özek, Sezer Külekçi̇, Rahmi̇ Örs, Kürşat Carman, Ferda Akdaş
Auditory Brain Stem Response Screening For Hearing Loss In High Risk Neonates, Hülya Bi̇lgen, İpek Akman, Eren Özek, Sezer Külekçi̇, Rahmi̇ Örs, Kürşat Carman, Ferda Akdaş
Turkish Journal of Medical Sciences
Hearing screening of neonates is the key to preventing the most severe consequences of congenital hearing loss. In this paper, the auditory brain stem responses (ABR) of neonates at high risk for hearing impairment at Marmara University Hospital Neonatal Intensive Care Unit are reported. One hundred fifty-four high-risk neonates underwent screening by ABR carried out according to the US Joint Committee on Hearing 1994 Position Statement. One hundred and fourteen of them passed the first ABR test while 40 patients failed. The number of patients with sensorineural and conductive hearing deficit was 5 and 35, respectively. Fifteen of the infants …
Clinical Efficacy Of Topical Clindamycin Phosphate And Azelaic Acid On Acne Vulgaris And Emergence Of Resistant Coagulase-Negative Staphylococci, Meti̇n Özkan, Gül Durmaz, İlham Sabuncu, Nurhan Saraçoğlu, Yurdanur Akgün, Seli̇m Murat Ürer
Clinical Efficacy Of Topical Clindamycin Phosphate And Azelaic Acid On Acne Vulgaris And Emergence Of Resistant Coagulase-Negative Staphylococci, Meti̇n Özkan, Gül Durmaz, İlham Sabuncu, Nurhan Saraçoğlu, Yurdanur Akgün, Seli̇m Murat Ürer
Turkish Journal of Medical Sciences
In this study, the uses of topical clindamycin phosphate and azelaic acid were compared from point of clinical efficacy and emergence of resistant coagulase-negative staphylococci (CNS). Each group contained 20 patients. Pre- and post-treatment acne grades and comparison of two groups were evaluated by using the Wilcoxon and Spearman statistical techniques. The sensitivity of CNS to azelaic acid and to clindamycin phosphate were searched by microbroth dilution technique. Azelaic acid was found more effective in reducing acne grade. Eleven CNS strains were found resistant to clindamycin phosphate before treatment. After 8 weeks of therapy with topical clindamycin phosphate 18 of …
Lamotrigine Treatment In Childhood Drug-Resistant Epilepsy, Nedret Uran, Gül Serdaroğlu, Şebnem Çalkavur, Erki̇n Serdaroğlu
Lamotrigine Treatment In Childhood Drug-Resistant Epilepsy, Nedret Uran, Gül Serdaroğlu, Şebnem Çalkavur, Erki̇n Serdaroğlu
Turkish Journal of Medical Sciences
Rationale: In this study the efficacy of Lamotrigine was evaluated in children with medically intractable epilepsy. Methods: 22 epileptic children, ranging between 4.2 years and 15 years of age (mean 9.3 years) were included in this study. Twelve (54.5%) were male and 10 (45.5%) were female. The seizure types were classified according to the International League Against Epilepsy criteria: simple partial seizures (8 cases), infantile spasms (4 cases), generalized tonic-clonic seizures (2 cases), tonic seizures (2 cases), complex partial seizure (2 cases), typical absence seizures (2 cases), myoclonic astatic seizures (1 case) and atypical absence seizures (1 case). The neurological …
High-Dose Intravenous Immunoglobulin Treatment In Intractable Childhood Epilepsy, Nedret Uran, Gül Serdaroğlu, Erki̇n Serdaroğlu, Sema Kalkan, Tuğrul Özcan
High-Dose Intravenous Immunoglobulin Treatment In Intractable Childhood Epilepsy, Nedret Uran, Gül Serdaroğlu, Erki̇n Serdaroğlu, Sema Kalkan, Tuğrul Özcan
Turkish Journal of Medical Sciences
Rationale: Intractable childhood epilepsy is characterised by convulsions, which are resistant to treatment with adequate dosage, combination and duration of appropriate anticonvulsant drugs. Many clinical and experimental studies support the role of the immune mechanism in the pathogenesis of childhood epilepsy. The purpose of the present study is to ascertain the possible efficacy of intravenous immunoglobulin in the treatment of intractable childhood epilepsy. Methods: The children aged 4-8 years suffering from intractable childhood epilepsy were treated with high-dose intravenous immunoglobulin (400 mg/kg) 5 times in the first week, on the 15th and 30th days. The treatments were repeated every 4 …
Leukocytosis As A Parameter In Management Of Organophosphate Intoxication, Muhammet Güven, Ayhan Doğukan, Hülya Taşkapan, Mustafa Çeti̇n
Leukocytosis As A Parameter In Management Of Organophosphate Intoxication, Muhammet Güven, Ayhan Doğukan, Hülya Taşkapan, Mustafa Çeti̇n
Turkish Journal of Medical Sciences
No abstract provided.
Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas
Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas
Turkish Journal of Medical Sciences
No abstract provided.
Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan
Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan
Turkish Journal of Medical Sciences
No abstract provided.
Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz
Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz
Turkish Journal of Medical Sciences
In preeclampsia, alterations in renal function, electrolyte and water metabolism are common findings. Recent studies have suggested that preeclampsia is associated with hypocalciuria. A total of 59 women were included in the present study, 15 of whom were nonpregnant (NP) healthy women, 20 normotensive pregnant women (NTP), and 24 pregnant women with severe preeclampsia (PEP). We compared the three groups in terms of calcium and phosphate excretion, and some parameters of renal function such as serum urea, creatinine and creatinine clearance. Urinary calcium and phosphate levels in the PEP group were significantly lower than in the NP group (p< 0.001 and p< 0.01, respectively) and NTP group (p< 0.001 and p< 0.01, respectively). The serum urea levels were higher in the PEP group than in the NP and NTP (p< 0.001) groups. The same pattern of increase in the PEP group was valid for serum creatinine concentrations as compared with the NP (p< 0.01) and NTP (p< 0.001) levels. The glomerular filtration rate measured by creatinine clearance was lower in preeclamptic women than in normotensive pregnant women (p< 0.01). Patients with preeclampsia had significantly lower (p< 0.001) excretion of calcium than the NP and NTP groups (p< 0.001). Likewise, the phosphate levels were lower in women with preeclampsia than in the NP and NTP groups (p< 0.01). There was no correlation between parameters of renal function and calcium or phosphate excretion. Hypocalciuria and hypophosphateuria were found to be important features of severe preeclampsia and probably indirectly are related to the altered renal function seen in toxemia of pregnancy.
Experimentally Developed Secondaryechinococcosis In Pleural And Peritoneal Cavitiesand The Utility Of Serological Tests During Thefollow Up, Kadi̇r Kazez, Mustafa Şahi̇n, Celaletti̇n Vatansev, Yücel Aritaş, Faruk Aksoy, Hüsametti̇n Vatansev
Experimentally Developed Secondaryechinococcosis In Pleural And Peritoneal Cavitiesand The Utility Of Serological Tests During Thefollow Up, Kadi̇r Kazez, Mustafa Şahi̇n, Celaletti̇n Vatansev, Yücel Aritaş, Faruk Aksoy, Hüsametti̇n Vatansev
Turkish Journal of Medical Sciences
Secondary echinococcosis is an important complication of hydatid disease and is not rare in the peritoneal cavity. However, the frequency of secondary hydatidosis in the pleural cavity is not very well known. This study was planned to elicit the frequency of secondary cyst development in the pleural cavity, and to compare this with secondary peritoneal hydatidosis. It was also intended to follow up cyst development by serological tests. Twelve white female Island rabbits were used. The mean weight of the rabbits was 2450±420 g. Cystic fluid containing protoscolex, hydatid sand and germinative membrane homogenate was injected via an 18 F …
The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin
The Isolation Rate And Antibiotic Resistantpattern Of Helicobacter Pylori In Dyspepticpatients, Esra Ağel, Bengül Durmaz, Mehmet Refi̇k Tevfi̇k, Nergi̇s Aşgin
Turkish Journal of Medical Sciences
In order to determine the isolation rates of Helicobacter pylori in dyspeptic patients, 167 biopsy specimens were examined using different methods, including culturing, microscopy and the rapid urease test. Resistance to commonly used antimicrobials was investigated using the disk diffusion method. Of the 167 specimens, 82(49.1%) were found to be positive for Helicobacter pylori in culture and 72(43 %) were positive in the urease biopsy test. Using Gram staining, Helicobacter pylori were observed in 43 (25.7 %) of the specimens. The resistance rate of the isolates was 53 % for metronidazol, 8% for both clarithromycin and ciprofloxacin, and 4% for …
Effect Of Actinomycin D And Cycloheximide On Ischemic Preconditioning-Induced Delayed Cardioprotective Effect In Rats, Devinder Singh, Ajay Sharma, Manjeet Singh
Effect Of Actinomycin D And Cycloheximide On Ischemic Preconditioning-Induced Delayed Cardioprotective Effect In Rats, Devinder Singh, Ajay Sharma, Manjeet Singh
Pharmacy Faculty Articles and Research
The present study was designed to investigate the effect of actinomycin D, a transcription inhibitor, and cycloheximide, a translation inhibitor, on the delayed cardioprotective effect of ischemic preconditioning. Left thoracotomy was performed in anaesthetized rats at 4th/5th intercostal space and polypropylene suture (5-0) was employed to occlude left common coronary artery. Ischemic preconditioning was produced by four episodes of 5 min of coronary artery occlusion followed by 5 min of reperfusion and thoracic cavity was sutured. Left thoracotomy was performed again after 24 hr of ischemic preconditioning and left coronary artery was occluded for 30 min followed by reperfusion for …
The Relationship Between Functional And Histological Changes In Muscle Following Eccentric Exercise In Mice, Michael John Newton
The Relationship Between Functional And Histological Changes In Muscle Following Eccentric Exercise In Mice, Michael John Newton
Theses: Doctorates and Masters
Exercise-induced muscle damage (EIMD) is known to be produced by novel or unaccustomed exercise, especially high force eccentric contractions. Histological myofibre disruption, force loss and muscle soreness are associated with EIMD and have implications for sporting performance. Traditional practices of assessing the extent of disruption to the myofibres is by performing needle biopsies and subsequently analysing the histology of the fibres. Recently there has been interest in investigating whether changes in force production and contractile properties of muscle following damaging exercise correlate strongly with the magnitude of disruption to the myofibres. The main aim of this study was to investigate …
A Linkage Study Of Autism Using Multipoint Sib-Pair Analysis, Tamara Rogers
A Linkage Study Of Autism Using Multipoint Sib-Pair Analysis, Tamara Rogers
Theses: Doctorates and Masters
Autism is a severe developmental disorder that was first described by Kanner in 1943. It is characterised by four major criteria: marked social deficits, delay in language development, a restricted range of stereotyped repetitive behaviours and onset of the disease within the first three years of life. The last decade of research has provided support for a strong genetic basis in the aetiology of autism. Firstly, a number of genetic conditions, such as fragile X syndrome, chromosome 15 anomalies and tuberous sclerosis, have been associated with autism. Secondly, family studies have demonstrated that the recurrence risk for autism among siblings …
Molecular Investigations In The Role Of The Galk1 Gene In Galactokinase Deficiency, Michael L. Hunter
Molecular Investigations In The Role Of The Galk1 Gene In Galactokinase Deficiency, Michael L. Hunter
Theses : Honours
Galactokinase deficiency is an autosomal-recessive inborn error of galactose metabolism whose major clinical manifestation is the development of cataracts during the first months of life. This metabolic disorder is caused by defects in the first enzyme of the Leloir pathway, galactokinase, encoded by the gene GALK1 on chromosome 17q24. Despite the identification of a number of conserved domains in GALK1, understanding of the functional significance of these regions and the molecular basis of the disorder is limited. This is largely due to the rarity of the disease and the fact that the small number of GALK1 mutations identified to-date are …
Isovolumic Regulation In Nervous Tissue: A Novel Mechanism Of Cell Volume Regulation, O. Quesada, R. Franco, K. Hernandez-Fonseca, K. Tuz
Isovolumic Regulation In Nervous Tissue: A Novel Mechanism Of Cell Volume Regulation, O. Quesada, R. Franco, K. Hernandez-Fonseca, K. Tuz
School of Veterinary and Biomedical Sciences: Faculty Publications
Cell volume regulation is a property present in most animal cell lineages that allows them to recover their original volume after events of swelling or shrinkage. Such events can be caused by changes in external osmolarity or to osmotic gradients generated during normal cell functioning.4,6 The mechanism of cell volume regulation involves transmembrane fluxes of osmotically active solutes in the necessary direction to counteract the net gain or loss of intracellular water.9 The process through which cells recover their normal volume after swelling is named Regulatory Volume Decrease (RVD). This consists of the efflux of inorganic osmolytes, such as K …
A Cultivated Taste For Yeast., C Brenner
A Cultivated Taste For Yeast., C Brenner
Kimmel Cancer Center Faculty Papers
The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.
Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci
Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci
Turkish Journal of Medical Sciences
Chitosan, a derivative of the natural polysaccharide chitin, is known for its biocompatibility and metal-binding capacity. The aim of this study was to combine these two properties of chitosan and investigate its potential as a new iron (III) ion (ferric ion) adsorbing agent. The development of a safe and orally active iron chelating agent is especially important for the treatment of thalassemics. In this study, the physicochemical parameters affecting the ability of chitosan flakes to adsorb iron (III) ions were studied by complexometric titration. The results showed that the iron (III) adsorption capacity of chitosan increases with the amount of …
Infective Panniculitis In A Child With Juvenile Rheumatoid Arthritis And Iga Deficiency, Ayça Törel Ergür, Meli̇h Akyol, Esi̇n Yildiz
Infective Panniculitis In A Child With Juvenile Rheumatoid Arthritis And Iga Deficiency, Ayça Törel Ergür, Meli̇h Akyol, Esi̇n Yildiz
Turkish Journal of Medical Sciences
No abstract provided.
Biosynthesis Of Polyhydroxybutyrate And Its Copolymers And Their Use In Controlled Drug Release, Füsun Türesi̇n, Zeynep Gümüşyazici, Fatma N. Kök, İhsan Gürsel, N. Gürdal Alaeddi̇noğlu, Vasif Hasirci
Biosynthesis Of Polyhydroxybutyrate And Its Copolymers And Their Use In Controlled Drug Release, Füsun Türesi̇n, Zeynep Gümüşyazici, Fatma N. Kök, İhsan Gürsel, N. Gürdal Alaeddi̇noğlu, Vasif Hasirci
Turkish Journal of Medical Sciences
Our aim was to prepare antibiotic loaded rods with biotechnologically produced biodegradable polymers and use them in the treatment of osteomyelitis by providing a high local dose of antibiotic at the infected site. For that purpose, first the production of PHB and its copolymers (P(3HB- co-3HV) and P(3HB- co-4HB)) by Alcaligenes latus and Alcaligenes eutrophusin the shake-flask cultures and in a fed-batch fermenter and their purification and characterization were performed. The polymers were then used in the preparation of the sulbactam-cefoperazone loaded rods. To predict the in vivo behavior of the controlled release system, the in vitro release kinetics of …
Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat
Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat
Turkish Journal of Medical Sciences
Most current hypotheses regarding the pathophysiologic mechanisms of pregnancy-induced hypertention point to early placental abnormalities. Therefore, we attempted to determine whether serum human chorionic gonadotropin (hCG) levels reflect a different trophoblastic secretory response of preeclampsia. Thirteen pregnant women with severe preeclampsia were matched with twenty-one normotensive pregnant women with singleton pregnancies in the third trimester. Serum b-hCG levels were found to be significantly higher in severe preeclampsia, compared with controls (p
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Turkish Journal of Medical Sciences
No abstract provided.
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
Turkish Journal of Medical Sciences
The effects of repeated halothane anaesthesia on 6-10 week old male, Mus musculus albino mice weighing 29-32 g were studied. Halothane, a widely used anaesthetic, is known to be metabolised in the liver to toxic intermediates through cytochrome P4502E1 (CYP2E1). During the first week of repeated dosage, glucose-6- phosphate dehydrogenase (G6PDH) activity decreased in both erythrocytes and liver cells, and during this time, livers increased significantly in weight and suffered histopathological damage, the damage increasing with the dosage of halothane, in the range 0.25-1.0 ml twice daily. When repeated anaesthesia was continued for a second week, G6PDH activity increased significantly …
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Turkish Journal of Medical Sciences
The aim of this study was to determine PCNA (Proliferating Cell Nuclear Antigen) and Ki-67 expression of various soft tissue sarcomas (STS) immunohisto-chemically and to correlate with the histologic grade of these tumors. Retrospectively 185 cases of STS were re-examined. Of the 185 cases, 35 primary STS cases which were localized in the extremities and trunk wall were included in this study. Anti-PCNA and Anti-Ki-67 monoclonal antibodies were applied to the paraffin sections of tumor tissues immunohistochemically. A semiquantitative score was employed to assess the percentage of cells that were positively stained. The comparison of the positively stained tumor cell …
The Global Carbon Metabolism Regulator Crc Is A Component Of A Signal Transduction Pathway Required For Biofilm Development By Pseudomonas Aeruginosa, George A. O'Toole, Karine A. Gibbs, Paul W. Hager, Paul V. Phibbs, Roberto Kolter
The Global Carbon Metabolism Regulator Crc Is A Component Of A Signal Transduction Pathway Required For Biofilm Development By Pseudomonas Aeruginosa, George A. O'Toole, Karine A. Gibbs, Paul W. Hager, Paul V. Phibbs, Roberto Kolter
Dartmouth Scholarship
The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite repression control (Crc) protein, which plays a role in the regulation of carbon metabolism, is necessary for biofilm formation in Pseudomonas aeruginosa. Using phase-contrast microscopy, we found that a crc mutant only makes a dispersed monolayer of cells on a plastic surface but does not develop the dense monolayer punctuated by microcolonies typical of the wild-type strain. This is a phenotype identical to that observed in mutants …
Auto-Inhibition Of Ets-1 Is Counteracted By Dna Binding Cooperativity With Core-Binding Factor Α2, Tamara L. Goetz, Ting-Lei Gu, Nancy A. Speck, Barbara J. Graves
Auto-Inhibition Of Ets-1 Is Counteracted By Dna Binding Cooperativity With Core-Binding Factor Α2, Tamara L. Goetz, Ting-Lei Gu, Nancy A. Speck, Barbara J. Graves
Dartmouth Scholarship
Auto-inhibition is a common transcriptional control mechanism that is well characterized in the regulatory transcription factor Ets-1. Autoinhibition of Ets-1 DNA binding works through an inhibitory module that exists in two conformations. DNA binding requires a change in the inhibitory module from the packed to disrupted conformation. This structural switch provides a mechanism to tightly regulate Ets-1 DNA binding. We report that the Ets-1 partner protein core-binding factor α2 (CBFα2; also known as AML1 or PEBP2) stimulates Ets-1 DNA binding and counteracts auto-inhibition. Support for this conclusion came from three observations. First, the level of cooperative DNA binding (10-fold) was …