Digital Commons Network^™

Thyroid Hemiagenesis In A Patient With Hypothyroidism*, Murat Acar, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Ramazan Albayrak

Turkish Journal of Medical Sciences

AR, Aylin YÜCEL, Bumin DEĞİRMENCİ, Ramazan ALBAYRAK Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyon - TURKEY

Association Of Invasive Breast Carcinoma And Glioblastoma Multiforme: A Case Report With Histological And Immunohistochemical Features, M. Şerefetti̇n Canda, Meri̇h Güray, R. Serhat Erbayraktar, Feri̇dun Acar, Tülay Canda

Turkish Journal of Medical Sciences

ettin CANDA^1, Merih GÜRAY^1, R. Serhat ERBAYRAKTAR^2, Feridun ACAR^2, Tülay CANDA ^1Department of Pathology, Faculty of Medicine, Dokuz Eylül University, İnciraltı, İzmir - TURKEY ^2Department of Neurosurgery, Faculty of Medicine Dokuz Eylül University, İnciraltı, İzmir - TURKEY

Reconstruction Of Localized Defects Of The Anterior Maxillary Ridge With Autogenous Bone Graft Before Insertion Of A Single Implant, Yilmaz Günaydin, Yavuz Si̇nan Aydintuğ, Keri̇m Ortakoğlu, Meti̇n Şençi̇men, Mehmet Dalkiz

Turkish Journal of Medical Sciences

ÜNAYDIN^1, Yavuz Sinan AYDINTUĞ^1, Kerim ORTAKOĞLU^1, Metin ŞENÇİMEN^1, Mehmet DALKIZ^2 ^1Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara - Turkey ^2Department of Prosthetic Dentistry, Gülhane Military Medical Academy, Ankara - Turkey

Reversible Posterior Leukoencephalopathy Syndrome Secondary To Acute Hepatic Failure, Hamza Karabi̇ber, Onur Kutlu, Alpay Alkan, İsa Üzüm, Cengi̇z Yakinci

Turkish Journal of Medical Sciences

RABİBER^1, Onur KUTLU^2, Alpay ALKAN^3, İsa ÜZÜM^2, Cengiz YAKINCI^2 ^1Department of Pediatrics, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş - TURKEY ^2Department of Pediatrics, Faculty of Medicine, İnönü University, Malatya - TURKEY ^3Department of Radiology, Faculty of Medicine, İnönü University, Malatya - TURKEY

Effect Of Vitamin E On Kidney Preservation Using Isolated Perfused Dog Kidney, Adnan Şahi̇n, Cem Algin, Çağatay Sezgi̇n, Enver İhti̇yar

Turkish Journal of Medical Sciences

Unsuccessful cadaveric kidney transplantation still remains as an important problem in organ transplantation. Cold storage solutions are not very efficient for kidney preservation. Vitamin E is an important dietary antioxidant, which may play a vital role in preventing free radical perfusion injury. We investigated the effect of vitamin E on kidney preservation with Euro-Collins (EC) solution using the isolated perfused dog kidney model. Recipients were randomly divided into 3 groups: group 1 (n = 6), immediately reperfused with EC solution, given laboratory pelleted diet and drinking water for 4 weeks; and group 2 (n = 6), flushed, and stored with …

Femoral Sulcus Angle Measurements: An Anatomical Study Of Magnetic Resonance Images And Dry Bones, Khalil Awadh Murshed, Aynur Emi̇ne Çi̇çekci̇başi, Taner Zi̇ylan, Aydin Karabacakoğlu

Turkish Journal of Medical Sciences

The sulcus angle of the femoral trochlea is particularly important for evaluating the patellofemoral joint. Our experimental study aimed to assess the osseous femoral sulcus angle radiologically in the right and left knees and osteologically in the right and left femurs in males and females. The osseous sulcus angle of 28 male right, 22 male left, 21 female right and 29 female left knees was measured on magnetic resonance images (MRIs) and by a goniometer; the angle was measured in 40 right and 40 left femurs. In MRIs, the mean sulcus angle in males and in females was 134° ± …

Soft Tissue Profile Changes In Anatolian Turkish Girls And Boys Following Orthodontic Treatment With And Without Extractions, Serpi̇l Hazar, Sercan Akyalçin, Hayal Boyacioğlu

Turkish Journal of Medical Sciences

The choice of extraction is critical in treatment planning, and its impact on the final facial appearance can be quite dramatic. Evaluation of facial profile esthetics both before and after treatment should be made cautiously. An orthodontist should be conscious of changes brought about by treatment and by late adolescent growth as well as differences in the dentofacial structures of various ethnic groups. The purpose of this cephalometric investigation was to determine the changes in the soft tissue profile of Turkish children treated with and without extractions. An assessment of pre- and post-treatment faces, chosen from our clinical records by …

Identical Twins Presenting With Hydrocephalus, Ahmet Çolak, Murat Kutlay, Burak O. Boran, Nusret Demi̇rcan

Turkish Journal of Medical Sciences

LAK, Murat KUTLAY, Burak O. BORAN, Nusret DEMİRCAN Department of Neurosurgery, GATA Haydarpaşa Training Hospital, İstanbul - TURKEY

A Family With Chronic Progressive External Ophthalmoplegia, Ayşe Fi̇li̇z Koç, Suzan Zorludemi̇r, Hacer Bozdemi̇r

Turkish Journal of Medical Sciences

KOÇ^1, Suzan ZORLUDEMİR^2, Hacer BOZDEMİR^1 ^1Department of Neurology, Faculty of Medicine, Çukurova University, Adana - Turkey ^2Department of Pathology, Faculty of Medicine, Çukurova University, Adana - Turkey

Spinocerebellar Ataxia With A Novel Chromosomal Defect: Del 5q34 - A Case Report, Ayşe Fi̇li̇z Koç, Yakup Sarica, Di̇lara Süleymanova Karahan

Turkish Journal of Medical Sciences

KOÇ^1, Yakup SARICA^1, Dilara SÜLEYMANOVA KARAHAN^2 ^1Department of Neurology, Faculty of Medicine, Çukurova University, Adana - Turkey ^2Department of Molecular Biology, Faculty of Medicine, Çukurova University, Adana - Turkey

Recovery Of 1-Chloro-2,4-Dinitrobenzene Detoxification By N-Acetyl- L-Cysteine In Glutathione Predepleted Human Erythrocytes, Deni̇z Yildiz, C.Işil Kuran

Turkish Journal of Medical Sciences

Glutathione is an important thiol-containing compound involved in the detoxification process in erythrocytes. Its thiol group reacts with a variety of xenobiotics in a glutathione S-transferase catalyzed reaction to form conjugates that are effluxed from the erythrocytes by an ATP dependent transport mechanism. A well studied experimental system is the transport of the conjugate of glutathione and 1-chloro-2,4-dinitrobenzene. We investigated whether N-acetyl-L-cysteine protects the free-SH content and restores 1-chloro-2,4-dinitrobenzene detoxification in erythrocytes or replaces glutathione in detoxification process in glutathione predepleted erythrocytes. Our results indicate that N-acetyl-L-cysteine restores the intracellular free-SH content following depletion by 1-chloro-2,4-dinitrobenzene and N-ethylmaleimide. N-acetyl-L-cysteine (10 …

Dr. Thomas Willis’ Famous Eponym: The Circle Of Willis, Çağatay Üstün

Turkish Journal of Medical Sciences

No abstract provided.

Brucellosis Seroprevalence In Southeast Turkey (Diyarbakır), Selahatti̇n Atmaca, Tuncer Özeki̇nci̇, Nezahat Akpolat, Saffet Elçi̇, Adnan Suay, Eralp Arikan

Turkish Journal of Medical Sciences

This study was conducted to determine brucellosis seropositivity in patients suspected of having brucellosis who sought treatment at the Central Laboratory of Dicle University Medical Faculty Hospital in southeast Turkey (Diyarbakır). 20,663 serum samples were collected during the study (1 August 2001-31 December 2002), and 14,480 sera were tested in a 12-month period on a seasonal basis by Rose-Bengal slide agglutination (RBSA), and positive sera were titrated by standard tube agglutination (STA). Titration values of 1/160 and above were considered positive. Of the 20663 sera, 463 (2.2%) tested positive on RBSA. Of these 463 sera, 267 (57.6%) tested positive on …

Preparation And Evaluation Of Ocular Inserts Containing Norfloxacin, M. Venkateshwar Rao, Somashekar Shyale

Turkish Journal of Medical Sciences

Norfloxacin is a poorly water soluble drug, and to improve its solubility it was complexed with b-cyclodextrin (BCD). Several ocular patches/inserts of norfloxacin-b-cyclodextrin were prepared in hydroxypropyl methyl cellulose (HPMC) matrix. The influence of rate controlling membranes made of ethyl cellulose (EC) alone and in combination with polyvinyl pyrrolidone K30 (PVP K30) in different proportions on drug release kinetics was studied. The data were subjected to regression analysis. Various physical characteristics of the films were evaluated. In vitro release studies were carried out in a fabricated flow through cell. All the films prepared were found to be uniform in thickness, …

Acute Hepatic Failure In A Case Of Acute Lymphoblastic Leukemia, Sali̇h Cesur, Pervi̇n Topçuoğlu, Ozan Aşik, Serhat Bi̇rengel, Muhi̇t Özcan

Turkish Journal of Medical Sciences

SUR^1, Pervin TOPÇUOĞLU^2, Ozan AŞIK^3, Serhat BİRENGEL^3 ,Muhit ÖZCAN^2 ^1Refik Saydam Hygiene Center Tuberculosis Reference Laboratory, Ankara – Turkey ^2 Department of Hematology, Faculty of Medicine, Ankara University, Ankara - Turkey ^3 Department of Infectious Diseases and Clinical Bacteriology, Faculty of Medicine, Ankara University, Ankara - Turkey

Effects Of Weight Loss Induced By Eight-Week Orlistat Therapy On Maximal Work Production Capacity In Obese Females, Oğuz Özçeli̇k, Hali̇l Doğan, Haluk Keleşti̇mur

Turkish Journal of Medical Sciences

The aim of this study was to examine the effects of weight loss induced by pharmacotherapy combined with a hypocaloric diet for a period of 8-weeks on maximal work (Wmax) production capacity and aerobic fitness in obese patients. Twelve obese females were put on an integrated energy restricted diet with orlistat supplement 3 x 120 mg/day. Each patient performed 3 incremental ramp exercise tests using an electromagnetically braked cycle ergometer: one at onset, one at the end of 4-weeks and one at the end of the 8-weeks to determine Wmax production capacity. The first 4-week therapy period resulted in a …

Sister Chromatid Exchange Frequency In Lymphocytes Cultured From Cotton Gin Workers, Münevver Atmaca, Hüseyi̇n Bağci, İbrahi̇m Açikbaş, Di̇li̇han Gümüş, Füsun Düzcan

Turkish Journal of Medical Sciences

Genetic biomonitoring of human populations exposed to potential mutagens/carcinogens can be performed using different genetic markers. Sister chromatid exchange (SCE) is one of the most extensively used markers of the early biological effects of DNA damaging agents. In order to assess the genotoxicity associated with exposure to cotton dust, we determined SCE frequency in peripheral blood lymphocytes cultured from 20 cotton gin workers and 20 controls. Student’s-t test indicated an increased frequency of SCE in lymphocytes of the workers (14.66 ± 4.18) compared to the controls (10.40 ± 1.37) (P < 0.0001). The Mann-Whitney U test indicated that the duration of exposure to cotton dust (10 years) and the work area were not related to the frequency of SCE (P > 0.05). The textile industry is rapidly expanding in Turkey, and …

Prevalence Of Listeria Species In Ice Creams Sold In The Cities Of Kahramanmaraş And Adana, Deni̇z Akman, Ni̇zami̇ Duran, Meti̇n Diğrak

Turkish Journal of Medical Sciences

In this study, the prevalence of Listeria spp. was investigated in the ice cream samples collected from the downtown stores of Kahramanmaras (28 samples) and Adana (30 samples). A total of 58 ice cream samples were analysed by the Food and Drug Administration (FDA) two-stage enrichment techniques. Growth of Listeria spp. was determined in 14 (24.1%) of the samples collected from Kahramanmaras and 10 (17.2%) samples from Adana. The results of the biochemical tests revealed that the bacterial growth in the samples from Kahramanmaras was Listeria grayi whereas 8 (13.8%) samples of Adana were Listeria grayi, the other two samples …

The Effects Of Asthma Education On Knowledge, Behavior And Morbidity In Asthmatic Patients, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This work was carried out to study the effect of asthma education on asthma knowledge, behavior and morbidity in asthmatic patients. A randomized double blind controlled study was conducted with 54 adults with asthma followed-up at the outpatient clinic of Chest Diseases and Tuberculosis at the Faculty of Medicine of Suleyman Demirel University. Patients were randomized to the verbal (n: 17), written (n: 19), and verbal-written (n: 18) education groups. Knowledge of asthma was measured at the baseline, and 2 months and 1 year after education. Compliance with treatment, correct inhaler skill and admisssons to hospital in the previous year …

Chromosomal Aberrations In Radiation Waste Repository Workers Detected By Fish Painting And Giemsa Staining, Petya Atanasova, Valeria Borisova Hadjidekova, Savina Agova, Milen Iovtchev

Turkish Journal of Medical Sciences

We aimed to assess chromosomal aberration frequency by means of FISH chromosome painting and conventional Giemsa staining in peripheral blood lymphocytes of workers at a nuclear waste repository. The results obtained from the exposed group were compared with those from a control group from the administrative staff of the company. Data on health and social status were collected using a questionnaire. Conventional chromosomal analysis after Giemsa staining did not indicate any significant difference between radiation exposed and control workers. Analysis after FISH chromosome painting revealed a 2-fold increased in genomic frequency of stable chromosomal translocations in the exposed group over …

Primary Thyroid Lymphoma Arising In The Setting Of Hashimoto’S Thyroiditis, Banu Doğan Gün, Mustafa Özkan Gün, Zi̇ya Karamanoğlu

Turkish Journal of Medical Sciences

AN GÜN^1, Mustafa Özkan GÜN^2, Ziya KARAMANOĞLU^3 ^1Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak - Turkey ^2Department of Pathology, Zonguldak SSK City Hospital, Zonguldak, Turkey ^3Department of General Surgery, Zonguldak SSK City Hospital, Zonguldak, Turkey

Editorial Message

Neurosciences

The Editors would like to thank the outgoing Editorial Board members who have now finished their term (Siema Bakheet, Saeed Bohlega and Abdelkarim Al-Qudah) and would also like to welcome Talat Al-Wazna, Yousef Comair and Hussein Malibary to the Advisory Board and Ibrahim Al-Orainy, Mahr Al-Jadid, Jun Kimura and Imad Najm to the Editorial Board. Our thanks also goes to the reviewers who have participated in the excellent review of manuscripts and books for the year 2003.

Nuovi Approcci Terapeutici Contro Il Cancro Del Colon, Giovanni Mario Pitari

Department of Pharmacology and Experimental Therapeutics Faculty Papers

This presentation was given in Augusta (Siracusa, Italy) for the 2004 Paul Harris Fellow Award, Rotary Foundation of Rotary International. The lecture discusses the clinical significance of the GC-C pathway and its potential as a therapeutic target for colon cancer and metastatic tumors. It underscores the importance of the dysregulation of the GC-C pathway in promoting colorectal tumorigenesis and of dietary calcium in the GC-C-mediated chemoprevention.

Questa e’ la presentazione per il Premio 2004 Paul Harris Fellow del Rotary International (Augusta, Siracusa, Italia). La dissertazione illustra l’importante significato clinico della via moleculare regulata da GC-C e dai suoi ligandi (guanilina, …

Analysis Of Expression Patterns Of Scl And Pax7 In The Mouse Brain For Potential Concomitant Function Within The Mesencephalon, Julie Stampalia

Theses : Honours

Investigation of the cascade of events that leads to brain formation during embryogenesis allows an understanding of the processes involved that may well be applicable to future neurodegenerative therapies. Two genes at work during embryonic neurogenesis in a brain region called the superior colliculus are Scl, a member of the basic helix-loop-helix factor transcription factor family and Pax7, a paired box transcription factor containing a homeobox dornain. The superior coiliculus forms part of the visual system in mammals and in sepmate studies both the Scl and Pax7 genes have been shown to be present in this region of the mouse …

Cd40-Associated Traf 6 Signaling Is Required For Disease Induction In A Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Cory L. Ahonen, W. James Cook, William R. Green

Dartmouth Scholarship

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.

Inactivation Of A Bacterial Virulence Pheromone By Phagocyte-Derived Oxidants: New Role For The Nadph Oxidase In Host Defense, Jacob M. Rothfork, Graham S. Timmins, Michael N. Harris, Xian Chen, Aldons J. Lusis, Michael Otto, Ambrose L. Cheung, Hattie D. Gresham

Dartmouth Scholarship

Quorum sensing triggers virulence factor expression in medically important bacterial pathogens in response to a density-dependent increase in one or more autoinducing pheromones. Here, we show that phagocyte-derived oxidants target these autoinducers for inactivation as an innate defense mechanism of the host. In a skin infection model, expression of phagocyte NADPH oxidase, myeloperoxidase, or inducible nitric oxide synthase was critical for defense against a quorum-sensing pathogen, Staphylococcus aureus, but not for defense against a quorum sensing-deficient mutant. A virulence-inducing peptide of S. aureus was inactivated in vitro and in vivo by reactive oxygen and nitrogen intermediates, including HOCl and ONOO(-). …

Creation Of Non-Human Primate Neurogenetic Disease Models By Gene Targeting And Nuclear Transfer, Robert B. Norgren

Journal Articles: Genetics, Cell Biology & Anatomy

Genetically modified rhesus macaques are necessary because mouse models are not suitable for a number of important neurogenetic disorders; for example, Kallmann's syndrome, Lesch-Nyhan's disease and Ataxia-Telangiectasia. Mouse models may not be suitable because there may be no mouse ortholog of the human gene of interest, as is the case for Kallmann's syndrome, or because mutant mice do not exhibit the same phenotype observed in humans, as is the the case for Lesch-Nyhan's disease and Ataxia-Telangiectasia. Non-human primate models of neurogenetic diseases are expected to more closely resemble human diseases than existing mouse models. Genetically modified rhesus macaques can be …

Cd46-Mediated Transduction Of A Species D Adenovirus Vaccine Improves Mucosal Vaccine Efficacy, Zenaido T. Camacho, Mallory A. Turner, Michael A. Barry, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. Low seroprevalent alternative viral vectors may be less impacted by preexisting immunity, but they may also have significantly different phenotypes from that of Ad5. In this study we compare species D Ads (26, 28, and 48) to the species C Ad5. In vitro transduction studies show striking differences between the species C and D viruses. Most notably, Ad26 transduced human dendritic cells much more effectively than Ad5. In vivo imaging studies showed strikingly different transgene expression profiles. The …

Phylogenetic Analyses Of Texas Isolates Indicate An Evolving Subtype Of The Clade B Feline Immunodeficiency Viruses, Eric A. Weaver, Ellen W. Collisson, Margaret Slater, Guan Zhu

Nebraska Center for Virology: Faculty Publications

Rigorous phylogenetic analyses were used to compare the nucleotide sequences of feline immunodeficiency virus strains isolated from Texas and throughout the world. The envelope V3-V4 sequences and capsid gene of the Texas isolates formed a cluster between subtypes B and E. Statistical comparisons with other published sequences confirmed that the Texas group is a unique cluster, possibly a new subtype, arising from subtype B.

The Effect Of Hyperbaric Oxygen Therapy (Hbo) When Used Postoperatively In Skin Grafting Over Radiated Tissue In The Rat, Burçak Tümerdem, Ufuk Emekli̇, Burcu Çelet Özden, Şami̇l Aktaş, Mi̇sten Demi̇ryont, Gönül Kemi̇kler

Turkish Journal of Medical Sciences

Under conditions that may risk the success of flap surgery, free skin grafting may be an option for the reconstruction of the irradiated area. Clinical observations reveal that skin grafts applied to irradiated area undergo ulceration, resulting in chronic open wounds. The role of hyperbaric oxygen therapy (HBO) in problem wounds is to increase the tissue oxygen tension to optimize fibroblast proliferation and collagen synthesis, to enhance the oxidative killing capacity of the white blood cells and to stimulate angiogenesis. HBO has also been shown to stimulate angiogenesis in radiation-damaged tissue. In view of this data, an animal model is …