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Incremental Genetic K-Means Algorithm And Its Application In Gene Expression Data Analysis, Yi Lu, Shiyong Lu, Farshad Fotouhi, Youping Deng, Susan J. Brown

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In recent years, clustering algorithms have been effectively applied in molecular biology for gene expression data analysis. With the help of clustering algorithms such as K-means, hierarchical clustering, SOM, etc, genes are partitioned into groups based on the similarity between their expression profiles. In this way, functionally related genes are identified. As the amount of laboratory data in molecular biology grows exponentially each year due to advanced technologies such as Microarray, new efficient and effective methods for clustering must be developed to process this growing amount of biological data.

Results

In this paper, we propose a new clustering …

Do Recent Data From The Seychelles Islands Alter The Conclusions Of The Nrc Report On The Toxicological Effects Of Methylmercury?, Alan H. Stern, Joseph L. Jacobson, Louise Ryan, Thomas A. Burke

Wayne State University Associated BioMed Central Scholarship

Abstract

In 2000, the National Research Council (NRC), an arm of the National Academy of Sciences, released a report entitled, "Toxicological Effects of Methylmercury." The overall conclusion of that report was that, at levels of exposure in some fish- and marine mammal-consuming communities (including those in the Faroe Islands and New Zealand), subtle but significant adverse effects on neuropsychological development were occurring as a result of in utero exposure. Since the release of that report, there has been continuing discussion of the public health relevance of current levels of exposure to Methylmercury. Much of this discussion has been linked to …

The Pharmacokinetics Of Nebulized Nanocrystal Budesonide Suspension In Healthy Volunteers., Walter Kraft, Barry Steiger, Don Beussink, John N. Quiring, Nancy Fitzgerald, Howard E. Greenberg, Scott A. Waldman

Department of Medicine Faculty Papers

Nanocrystal budesonide (nanobudesonide) is a suspension for nebulization in patients with steroid-responsive pulmonary diseases such as asthma. The pharmacokinetics and safety of the product were compared to those of Pulmicort Respules. Sixteen healthy volunteers were administered nanobudesonide 0.5 and 1.0 mg, Pulmicort Respules 0.5 mg, and placebo in a four-way, randomized crossover design. All nebulized formulations were well tolerated, with no evidence of bronchospasm. Nebulization times were significantly shorter for nanobudesonide compared to Pulmicort Respules. Because of a low oral bioavailability, plasma concentration of budesonide is a good marker of lung-delivered dose. The pharmacokinetics of nanobudesonide 0.5 and 1.0 mg …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

President's Message, David J. Stroup

Journal of the South Carolina Academy of Science

No abstract provided.

Scas Officers And Council Members 2004 - 2005

Journal of the South Carolina Academy of Science

No abstract provided.

Bioinformatics: An Undergraduate Research/Teaching Tool., Abhishek Agrawal, Valgene L. Dunham

Journal of the South Carolina Academy of Science

No abstract provided.

Building New Culture Media For Assisted Reproductive Technology., Mary N. Egbuniwe, H. Lee Higdon Iii, William R. Boone

Journal of the South Carolina Academy of Science

No abstract provided.

An Investigation Of The Acetabulum, The Femoral Head And The Ligament Of Femoral Head In Human Fetuses, İsmi̇han İlknur Uysal, Ahmet Salbacak, Mustafa İsmai̇l Sefa Kapicioğlu, Mustafa Büyükmumcu, Muzaffer Şeker, Aynur Emi̇ne Çi̇çekci̇başi

Turkish Journal of Medical Sciences

We investigated the morphometric characteristics of the acetabulum, the ligament of the femoral head (LFH) and the femoral head, and the relationships among them in 30 spontaneously aborted human fetuses. The maximum length and width of the LFH, the transverse and vertical diameters of the femoral head and the acetabulum, the height of the femoral head and the depth of the acetabulum were measured and the existence of any relationship among them was assessed statistically. The acetabulum was circular in 58.4% of cases and oval in 41.6%. The diameter of the femoral head was less than that of the acetabulum …

The Assessment Of A Family With Myotonic Dystrophy, Ayşe Fi̇li̇z Koç, Suzan Zorludemi̇r, Yakup Sarica

Turkish Journal of Medical Sciences

KOÇ^1, Suzan ZORLUDEMİR^2, Yakup SARICA^1 ^1Department of Neurology, Faculty of Medicine, Çukurova University Adana - Turkey ^2Department of Pathology, Faculty of Medicine, Çukurova University Adana - Turkey

Serum Adenosine Deaminase Levels In Patients With Brucellosis And In Healthy Subjects, Sali̇h Cesur, Kadi̇rhan Sunguroğlu, Kamruddi̇n Ahmed, Deni̇z Tezeren, Nagehan Oran Keseci̇, Sebahat Aksaray

Turkish Journal of Medical Sciences

The aim of this study was to determine the serum adenosine deaminase ( ADA ) levels in patients with brucellosis and compare them with the results of healthy individuals. Forty- eight subject were enrolled in this study : 34 patients with brucellosis and 14 healthy individuals. Serum ADA activity was assessed by spectrophotometer in patients with brucellosis and statistically compared with that of healthy individuals. A normal range of serum ADA was considered 5-35 IU/l. Serum ADA levels were also compared with Brucella agglutinations titers and serum C reactive protein (CRP). Serum ADA levels were found to be significantly higher …

Persistent Müllerian Duct Syndrome With Transverse Testicular Ectopia: A Case Report With Literature Review, Mustafa Fuat Açikalin, Özgül Paşaoğlu, Baran Tokar, Di̇lek İlgi̇ci̇, Hüseyi̇n İlhan

Turkish Journal of Medical Sciences

Fuat AÇIKALIN^1, Özgül PAŞAOĞLU^1, Baran TOKAR^2, Dilek İLGİCİ^1, Hüseyin İLHAN^2 ^1Department of Pathology, Faculty of Medicine, Osmangazi University, Eskişehir - Turkey ^2Department of Pediatric Surgery, Faculty of Medicine, Osmangazi University, Eskişehir - Turkey

Common Anorectal Conditions, Pravin J. Gupta

Turkish Journal of Medical Sciences

No abstract provided.

Leiomyoma Of The Ureter In A Child (The Youngest Reported Case) (Case Report), Bengü Çobanoğlu, İbrahi̇m H. Özercan, Orhan Yalçin, Ertürk Ergi̇n

Turkish Journal of Medical Sciences

BANOĞLU^1, İbrahim H. ÖZERCAN^1, Orhan YALÇIN^2, Ertürk ERGİN^2 ^1Department of Pathology, Faculty of Medicine, University of Fırat, Elazığ - Turkey ^2Department of Urology, Faculty of Medicine, University of Fırat, Elazığ - Turkey

Intravenous Dexmedetomidine Sedation For Spinal Anesthesia In The Prone Knee-Chest Position For Lumbar Laminectomy Surgery, Berri̇n Günaydin, Zerri̇n Özköse, Belde Tarhan

Turkish Journal of Medical Sciences

ÜNAYDIN^{1,2}, Zerrin ÖZKÖSE^1, Belde TARHAN^3 ^1Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey ^2Department of Pharmacology, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey ^3Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Beşevler, 06500, Ankara - Turkey

Pituitary Abscess Simulating Macroadenoma, Gülgün Yilmaz Ovali, Serdar Tarhan, Hüseyi̇n Şentürk, Petek Bayindir, Yüksel Pabuşçu

Turkish Journal of Medical Sciences

ILMAZ OVALI , Serdar TARHAN, Hüseyin ŞENTÜRK, Petek BAYINDIR, Yüksel PABUŞÇU Department of Radiology, Faculty of Medicine, Celal Bayar University, Manisa - Turkey

What The Hittites’ Tablets Tell Us? A Short Historical View Of Deafness On The Basic Of Genetics, Berna Arda, Murat Aksu

Turkish Journal of Medical Sciences

No abstract provided.

Lafora Body Disease: Clinical, Electrophysiological And Histopathological Findings, Ayşe Fi̇li̇z Koç, Hacer Bozdemi̇r, Suzan Zorludemi̇r, Gamze Almak, Ali̇ Özeren

Turkish Journal of Medical Sciences

iz KOÇ^1, Hacer BOZDEMİR^1, Suzan ZORLUDEMİR^2, Gamze ALMAK^1, Ali ÖZEREN^1 ^1Department of Neurology, Faculty of Medicine, Çukurova University, Adana - Turkey ^2Department of Pathology, Faculty of Medicine, Çukurova University, Adana - Turkey

Acute Motor Axonal Neuropathy Developing During Helicobacter Pylori Infection, Ahmet Gödekmerdan, A. Neşe Çitak Kurt, Abdullah Kurt, Ni̇met Kabakuş

Turkish Journal of Medical Sciences

No abstract provided.

Buccal Corticotomy For Closure Of Oroantral Openings: Case Report, Bedretti̇n Cem Şener, Hasan Gari̇p, Faysal Uğurlu, Kami̇l Göker

Turkish Journal of Medical Sciences

n Cem ŞENER, Hasan GARİP, Faysal UĞURLU, Kamil GÖKER Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, 80220 Nişantaşı, İstanbul - Turkey

Extensive Carotid Fibromuscular Dysplasia With Dissections And Aneurysm Of The Ascending Aorta, Zafer Koç, A. Muhteşem Ağildere, Ayşe Fi̇li̇z Koç, Osman Kizilkiliç, Özlem Yalçin

Turkish Journal of Medical Sciences

Ç^1, A. Muhteşem AĞILDERE^2, Filiz KOÇ^3, Osman KIZILKILIÇ^1, Özlem YALÇIN^1 ^1Department of Radiology, Faculty of Medicine, Adana Teaching and Medical Research Center, Başkent University, Adana - Turkey ^2Department of Radiology, Faculty of Medicine, Başkent University, Ankara - Turkey ^3Department of Neurology, Faculty of Medicine, Cukurova University, Adana – Turkey

Alternative Testing Methods - Reproductive Toxicity, Srinivasa Jayachandra, Maxim Pinto, Urban J.A.D'Souza

Turkish Journal of Medical Sciences

No abstract provided.

The Efficacy Of Intermittant Low-Dose Systemic Corticosteroid In The Treatment Of Alopecia Areata, Ahu Bi̇rol, Emel Erkek, Fatma Tuncez, Gülcan Saylam Kurti̇pek, Yeter Bağci, Mukadder Koçak

Turkish Journal of Medical Sciences

Alopecia areata (AA) is a common cause of non-scarring alopecia characterized by patchy hair loss. AA is difficult to treat because of its chronic and inflammatory nature. The aim of the present study was to investigate the effect of low-dose systemic corticosteroids in the treatment of AA. Fifteen patients with AA were included in this study. Systemic prednisolone 10-15 mg/day on 2 consecutive days per week for 6 months was administered. Fourteen patients (93.3%) had patchy alopecia areata. One patient (6.3%) had alopecia universalis. Seven (46.7%) patients showed complete healing, 5 (33.3%) showed partial response and 3 (20%) did not …

Body Fat Distribution And Plasma Lipid Profiles Of Patients With Multiple Sclerosis, Selçuk Çomoğlu, Serdar Yardimci, Zeki̇ Okçu

Turkish Journal of Medical Sciences

This study was performed to determine the body fat percentage, fat distribution and plasma lipid-cholesterol levels of patients with multiple sclerosis (MS). We compared the body fat percentage, distribution and lipid profile in 22 patients with definitive diagnosis of MS and age and height matched 16 healthy control subjects on normal diets. Poser criteria was used to determine the MS diagnosis. Body fat percentage and distribution were evaluated anthropometrically by measuring skin fold thickness from 7 different reference points of the body. The parameters of the body composition were obtained by using the equations of Durning, Womersly and Siri. Body …

Mechanisms Of Glybenclamide-Mediated Anti-Arrhythmia And Ischemic Conditionining In A Rat Model Of Myocardial Infarction: Role Of Yohimbine Treatment, Ömer Bozdoğan, Ersöz Gonca, Eylem Suveren Ti̇ryaki̇, Fati̇h Gökçe

Turkish Journal of Medical Sciences

Glibenclamide (Glyburide), a widely used second-generation sulfonylurea hypoglycemic agent, is a known specific blocker of adenosine triphosphate (ATP) sensitive potassium (K+) channels. Although the blockage of the ATP dependent potassium channel reduces arrhythmia, it increases enfarct size. Yohimbine is an alpha-2 blocker that reduces infarct size as suggested by several studies. We hypothesized that a combination of yohimbine and glibenclamide may be more effective in reducing the arrhythmia following ligation. The arteria descendence (LAD) branch of the left coronary artery in conscious rats was ligated and arrhythmia was recorded during the 15 min following coronary ligation. Sixteen hours after coronary …

Neurilemmoma Originating From The Hypoglossal Nerve In The Floor Of The Mouth, Çağri Deli̇lbaşi, Hiroshi Kohara, Kana Takao, Seiji Iida, Mikihiko Kogo

Turkish Journal of Medical Sciences

LİLBAŞI, Hiroshi KOHARA, Kana TAKAO, Seiji IIDA, Mikihiko KOGO Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry Osaka University, Osaka-Japan

Asymmetric Maxillary First Molar Distalization With The Transpalatal Arch, Serhat Eyüboğlu, Ali̇ Osman Bengi̇, Ari̇f Ümi̇t Gürton, Erol Akin

Turkish Journal of Medical Sciences

The purpose of this study was to determine the dentoalveolar and skeletal effects of a Goshgarian transpalatal arch (TPA) in unilateral maxillary first molar distalization. The treatment group consisted of 15 patients (6 females and 9 males) between 10.8 and 12.1 years of age. The maxillary first molars, which were in a dental Class I relationship (anchorage molars), were the anchorage units, while the molars in Class II relationship (distalized molars) were distalized using a TPA with 150 g. of force. Lateral head films, study models and clinical photographs of all the patients were taken before and after distalization. The …

Insulin Sensitivity, B Cell Function And Serum Lipid Levels In Helicobacter Pylori Positive, Non-Obese, Young Adult Males, Mehmet Dursun, Mi̇that Bahceci̇, Alpaslan Tuzcu, Şeri̇f Yilmaz, Fi̇kri̇ Canoruç

Turkish Journal of Medical Sciences

It is not clear whether Helicobacter pylori (Hp) infection affects insulin levels and insulin sensitivity. We aimed to determine insulin sensitivity and beta cell function, and to evaluate serum lipids in subjects with and without Hp infection. Eighty non-obese young adult males, 40 of whom were Hp positive and 40 were negative, were included in the study. Two endoscopic biopsy specimens were obtained from each subject. Height, weight and waist-hip circumference were measured, and body mass index (BMI) was calculated. Serum glucose, total, HDL, LDL and VLDL-cholesterol and triglyceride levels were determined. Body fat mass and percentage were determined by …

Point Of Entry To The Health Care System A Community Based Study In Edirne, Turkey*, Erkan Meli̇h Şahi̇n, Özlem Öztürk Şahi̇n

Turkish Journal of Medical Sciences

Being the first contact point in the health system is one of the main features of primary health care. Our aim is to identify whether the primary care institutions in Edirne are used as a first contact point for health services. A survey prepared for this study was carried out by face-to-face interviews with 407 families, a representative sample of the Edirne municipality region. The 1,008 adults and adolescents in these families were asked to answer the questions "to which health care institutions do you apply first when you seek health care?" and "to which health care institution do you …

Investigation Of The Bactericidal Effects Of Vancomycin And Quinupristin/Dalfopristin On Staphylococcus Aureus Isolates, Mi̇ne Hoşgör Li̇moncu, Şafak Ermertcan, Güner Coşar

Turkish Journal of Medical Sciences

The present study aimed to determine the correlation between the bactericidal activity of vancomycin and quinupristin/dalfopristin (Q/D) on Staphylococcus aureus isolates and their minimal inhibition concentrations. The in-vitro susceptibilities of the 99 S. aureus isolates to vancomycin and Q/D were investigated by agar dilution. Thirty methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA) vancomycin and Q/D susceptible isolates were involved in time-kill studies. While both MRSA and MSSA isolates were susceptible to vancomycin, 96% of both isolates were determined as susceptible to Q/D. In the time-kill test, after 6 h of incubation vancomycin exhibited a bactericidal activity of …