Digital Commons Network^™

The Prevalence Of Smoking And The Knowledge Of Smoking Hazards And Smoking Cessation Strategies Among Hiv Positive Patients In Johannesburg, South Africa, Peter Waweru, R. Anderson, H. Steel, Wdf. Venter, D. Murdoch, C. Feldman

Internal Medicine, East Africa

Background: While the detrimental effects of smoking among HIV positive patients have been well documented, there is a paucity of data regarding cigarette smoking prevalence among these patients in South Africa.

Objectives: To establish the frequency, demographics, and knowledge of harmful effects and of smoking cessation strategies among HIV-positive patients in Johannesburg, South Africa.

Methods: A prospective cross-sectional survey, using a structured questionnaire interview, of HIV-positive patients attending the HIV Clinic at the Charlotte Maxeke Johannesburg Academic Hospital between 1 July 2011 and 31 October 2011.

Results: Of 207 HIV positive patients attending an ARV roll-out clinic, 31 (15%) were …

Structured Genome-Scale Variant And Clinical Data Reporting For Meta-Analysis In An Era Of Genomic Medicine, Darrell L. Dinwiddie, Carol J. Saunders, Emily G. Farrow, Sarah E. Soden, Neil A. Miller, Stephen F. Kingsmore

Manuscripts, Articles, Book Chapters and Other Papers

The Journal of Genomes and Exomes is a new, peer-reviewed, open-access, online publication whose scope comprises reporting of high quality genome, exome, and gene panel sequences with attendant, detailed phenotypes. The intent of this journal is to facilitate comparisons between genome, exome and gene panel sequencing studies in order to assist significance testing of the genotypephenotype associations, particularly those in uncommon genetic diseases. While there is yet to be a consensus regarding these classifications, the definition of an empiric set is helpful in understanding error models. Herein we have suggested structured templates for submissions and the rationale for the data …

Exome Sequencing Reveals De Novo Germline Mutation Of The Mammalian Target Of Rapamycin (Mtor) In A Patient With Megalencephaly And Intractable Seizures, Laurie D. Smith, Carol J. Saunders, Darrell L. Dinwiddie, Andrea M. Atherton, Neil A. Miller, Sarah E. Soden, Emily G. Farrow, Ahmed T G Abdelmoity, Stephen F. Kingsmore

Manuscripts, Articles, Book Chapters and Other Papers

A de novo somatic mutation in the mammalian target of rapamycin (MTOR) has previously been described in one patient with hemimegalencephaly and epilepsy. Here, we present a case of a young girl with megalencephaly and intractable seizures who was found to have an MTOR mutation in multiple cell lineages (p.Cys1483Phe) and, therefore, presumed to be of germline origin. The mutation was detected in peripheral blood DNA by exome sequencing of the patient and her parents, substantiating the utility of this approach for detection of clinically relevant de novo variations.

Rational Use Of Antibiotics--A Quality Improvement Initiative In Hospital Setting, Sidrah Nausheen, Rabia Hammad, Ambreen Khan

Department of Obstetrics & Gynaecology

Objectives: To minimise irrational use of antibiotics by implementing guidelines for antibiotic usage in obstetrics and Gynaeocology.
Methods: The observational study was conducted from January to December 2010 at the maternity unit of Aga Khan Hospital for Women and children, Kharadar, a secondary care facility in Karachi, Pakistan. Data was collected from medical records related to the study period. Prophylactic antibiotics were given according to the American College of Obstetricians and Gynaecologists recommendation 2009. Surveillance was done by surgical site infection rates and infectious morbidity. Data was analysed on SPSS 13.
Results: Therapeutic antibiotic use was rationalized, reducing the use …

Insulin Resistance Impairs Response To Doxazosin Therapy In Men With Benign Prostatic Hyperplasia, Cevdet Serkan Gökkaya, Çeti̇n Volkan Özteki̇n, Cüneyt Özden, Emi̇n Öztürk, Bi̇nhan Kağan Aktaş, Ali̇ Memi̇ş

Turkish Journal of Medical Sciences

To evaluate the effects of insulin resistance (IR) on outcomes of doxazosin treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Materials and methods: This prospective study included 64 patients with LUTS due to BPH. LUTS were evaluated using the international prostate symptom score (IPSS) and maximum flow rate (Qmax) in uroflowmetry. Diagnosis of IR was achieved using homeostasis model assessment (HOMA) score and patients were grouped with respect to absence (group 1, n = 44) or presence (group 2, n = 20) of IR. Patients were evaluated before and after 3 months of daily doxazosin …

Molecular Characterization Of Acanthamoeba Isolated From Kayseri Well Water, Sali̇h Kuk, Süleyman Yazar, Süheyla Doğan, Ülfet Çeti̇nkaya, Çağri Şakalar

Turkish Journal of Medical Sciences

Potentially pathogenic free-living amoebae have a cosmopolitan distribution in soil, dust, air, and water. Generally, environmental free-living amoebae do not threaten human health. This study aimed to investigate the presence of Acanthamoeba in well waters drawn from different locations in Kayseri, Turkey, which are mainly used for drinking or irrigation by the residents in the region. Materials and methods: Twenty-nine samples, including 26 well water sediment samples and 3 tap water samples as the control, were collected from 3 different locations. Melting snow feeds 5, rain water 18, and tap water 3 of these wells. Results: Five of 26 well …

Right Ventricular Function And Its Relation With Timi Frame Count In The Coronary Slow Flow Phenomenon, Mustafa Yilmaz, Fatma Özlem Arican Özlük, Tezcan Peker, Adem Bekler, Kemal Karaağaç

Turkish Journal of Medical Sciences

To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P …

The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk

Turkish Journal of Medical Sciences

To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group …

The Effects Of Valsartan Treatment On Visfatin Levels And Lipid Profiles In Newly Diagnosed Hypertensives, İsmai̇l Atacan, Adem Parlak, Ümi̇t Aydoğan, Oktay Sari, Deni̇z Engi̇n Gök, Tuncer Çayci, Kenan Sağlam

Turkish Journal of Medical Sciences

In this study, the curative effect of valsartan on hypertension based on its effect on visfatin levels and lipid profiles was investigated. Materials and methods: Forty patients aged 38-60 with hypertension were included in the study. In order to determine initial visfatin levels and lipid profiles, blood samples were taken from the patients and all were started on 80-mg valsartan tablets. All patients were monitored for 12 weeks. Results: By using multivariate regression analysis, it was determined that visfatin levels affected systolic blood pressure (SBP) (P = 0.012, beta; -0.43, 95% CI: -0.092 to -0.012). After the patients received the …

Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün

Turkish Journal of Medical Sciences

We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS …

Effect Of Hepatic Steatosis On Virological Response To Nucleos(T)Ide Analogs Therapy In Patients With Chronic Hepatitis B, Ahmet Karaman, Şebnem Gürsoy, Işin Soyuer, Hati̇ce Karaman, Muhammet Edi̇p Torun, Mustafa Alper Yurci̇, Mevlüt Başkol, Kadri̇ Güven, Ömer Özbakir, Mehmet Yücesoy

Turkish Journal of Medical Sciences

To evaluate the impact of hepatic steatosis on the outcome of treatment in patients with chronic hepatitis B infection treated with oral antiviral therapy. Materials and methods: The study was designed in Erciyes University Medical Faculty Department of Gastroenterology. Patients who received oral antiviral therapy because of chronic hepatitis B were included in the study. Liver biopsy specimens were re-evaluated and classified according to Brunt’s steatosis classification. Virological response to oral antiviral therapy was compared between patients with and without steatosis. Results: One hundred and nineteen patients were included in the study, of which 36.1% had hepatic steatosis. Virological response …

Mmp-2, Timp-2, And Mmp-2/Timp-2 Complex Levels In Epidermoid Lung Cancer, Müfi̇de Öncel, Mehmet Aköz, Murat Öncel, Aysel Kiyici, Burhan Api̇li̇oğullari

Turkish Journal of Medical Sciences

To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls …

Neurocognitive Functioning In Young High-Risk Offspring Having A Parent With Bipolar I Disorder, Erdem Deveci̇, Erol Ozan, İsmet Kirpinar, Meltem Oral, Ali̇ Gökhan Daloğlu, Nazan Aydin, Ahmet Öztürk

Turkish Journal of Medical Sciences

To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO). Materials and methods: Thirty symptom-free BD1O and 37 CO were recruited. The groups (both all participants and those >=11 years of age) were well-matched for age, sex, IQ, and years of education. The neurocognitive battery included the Rey Auditory Verbal Learning and Memory Test, Controlled Word Association Test, Digit Span Test, Trail Making Test, Auditory Consonant Trigram Test, Wisconsin Card Sorting Test, Stroop Test, and Test of Variables of Attention. Results: The BD1O …

Assessment Of Left-Ventricular Diastolic Function In Diabetic Patients: The Role Of Cardiac Mr Imaging, İhsan Yüce, İbrahi̇m Hali̇l Tanboğa, Ümmügülsüm Bayraktutan, Enbi̇ya Aksakal, Hayri̇ Oğul, Ahmet Yalçin, Yeşi̇m Kizrak, Abdulmeci̇t Kantarci

Turkish Journal of Medical Sciences

To evaluate the reliability of cardiac magnetic resonance (CMR) imaging in diabetic patients with clinically suspected cardiomyopathy and to compare the consistency of CMR imaging with 2-dimensional echocardiography (2DE). Materials and methods: Twenty-one diabetic patients with clinically suspected cardiomyopathy were evaluated with CMR imaging and 2DE. Two observers for each modality performed the evaluation. Quantitative data (the ejection fraction, end-systolic volume, end-diastolic volume, left-ventricular mass index, and left-atrial volume index) were acquired from both observers. The data were compared for statistical agreement using the Bland-Altman test between the modalities. Results: The CMR examination and 2DE results were consistent with each …

Effects Of Obstructive Sleep Apnea Syndrome On Temperament And Character, Fatma Fi̇dan, Ömer Özbulut, Apdullah Ayçi̇çek, Ahmet Hakki Aşik, Mehmet Ünlü

Turkish Journal of Medical Sciences

There are few studies that have evaluated personality characteristics in patients with obstructive sleep apnea syndrome (OSAS). We aimed to evaluate 2 groups, OSAS patients and controls, using a temperament and character inventory (TCI) questionnaire. Materials and methods: Patients with OSAS symptoms and who underwent polysomnography in the sleep laboratory were included in the study. A TCI questionnaire was given to 52 patients. Those whose apnea-hypoapnea index (AHI) was >=10 were included as the OSAS group and those whose score was

Can Plasma-Free Dna Concentration Be A Diagnostic Tool In Critically Ill Septic Patients?, Başak Ceyda Meço, Fatma Handan Cuhruk, Melek Tulunay, Mehmet Oral, Mustafa Necmetti̇n Ünal

Turkish Journal of Medical Sciences

To investigate the diagnostic value of plasma-free DNA concentration (PF-DNA) in septic patients compared to nonseptic patients and to correlate it with clinical outcome. Materials and methods: Forty-two mechanically ventilated consecutive patients (11 septic, 31 nonseptic) admitted to the intensive care unit (ICU) were recruited. On admission, besides PF-DNA concentration, APACHE II and SOFA scores and serum C-reactive protein (CRP), procalcitonin (PCT), and serum lipid concentrations, together with clinical outcome, were assessed. Plasma samples from 11 volunteers were also collected. Appropriate statistics were used for analysis. Results: Median PF-DNA concentrations on admission were significantly higher in septic patients compared to …

The Effects Of An Adaptive Directional Beam Microphone On The Mismatch Negativity Responses Of Cochlear Implant Users In Noise, Asuman Erdoğan, Ferda Akdaş

Turkish Journal of Medical Sciences

To investigate the effects of noise on mismatch negativity (MMN) responses and the possible benefits of an adaptive directional BEAM microphone in noise during MMN recordings, and to compare the cochlear implant-evoked potential results with normal hearing subjects. Materials and methods: /da/ and /di/ speech stimuli were used to elicit MMN responses in 11 Freedom cochlear implant users and in 11 normal hearing subjects. Speech noise was delivered at 80 dB sound pressure level (-10 dB signal-to-noise ratio). All subjects were tested in quiet and noisy conditions. To compare the microphone effects, MMN responses for the cochlear implant group were …

Rehabilitation Idea Begins At Sumers, Yusuf Kemal Kemaloğlu, Pinar Yaprak Kemaloğlu, Güven Mengü

Turkish Journal of Medical Sciences

No abstract provided.

The Dose-Dependent Effect Of Grayanotoxin On The Cardiovascular System, Süha Türkmen, Ülkü Karagöz, Abdülkadi̇r Gündüz, Süleyman Türedi̇, Metehan Akça, Mehmet Yildirim

Turkish Journal of Medical Sciences

Mad honey (grayanotoxin, GTX) poisoning is caused by a toxin binding to the sodium channels of a cell membrane. This study investigates the dose-dependent effect of GTX on the cardiovascular system. Materials and methods: Twenty-four male Sprague Dawley rats were divided into 4 equal groups. Group 1 was the control group and was administered only saline. GTX-III was administered in doses of 200, 400, and 800 µg/kg for Groups 2, 3, and 4, respectively. After GTX-III injection, blood pressure and heart rate were recorded using an electrophysiological data acquisition system. Results: After 200 µg/kg GTX-III injection, at 31-60 min, the …

Prediction Of Neurological Outcome Using Bispectral Index In Patients With Severe Acute Brain Injury, Wang Xifeng, Zhang Lianshuang, Wu Dawei

Turkish Journal of Medical Sciences

To predict consciousness recovery and outcome of patients with severe acute brain injury using the bispectral index (BIS). Materials and methods: A prospective study of 189 brain-injured patients was made when they were without sedatives for at least 24 h. BIS, 95% spectral edge frequency (SEF), burst suppression ratio (SR), total power (TP), spontaneous electromyographic activity (EMG), and signal quality index (SQI) were recorded continuously for 30 min. Neurologic conditions were measured with the Glasgow Coma Score (GCSBIS) when recording BIS. Patients were followed for 30 days after injury to assess consciousness recovery and outcome. Results: There were statistically significant …

Ankaferd Blood Stopper: Does It Have A Role In Fracture Healing?, Murat Günay, Ramazan Amanvermez, Gökhan Keleş

Turkish Journal of Medical Sciences

To examine the effect of Ankaferd Blood Stopper (ABS) on bone healing using a rat femur fracture model. Materials and methods: Eight rats were used as a control group (group 1), which was not subjected to fractures. The remaining 48 rats were divided into 6 groups of 8 each. The femoral shaft fractures were produced by cutting with bone scissors. One milliliter of ABS was applied to the fracture region of groups 3 (day 7), 5 (day 21), and 7 (day 45), or rats treated with saline instead of ABS on the fracture region in groups 2 (day 7), 4 …

Influence Of Alpha Lipoic Acid On Epithelial Apoptosis In Experimental Periodontitis, Adem Kara, Sümeyra Akman, Tevfi̇k Demi̇rci̇, Taner Arabaci, Varol Çanakçi, Bünyami̇ Ünal

Turkish Journal of Medical Sciences

Alpha lipoic acid (ALA) is a powerful antioxidant. Its antiinflammatory effects and apoptotic mechanism have recently been studied in many diseases. This study aimed to investigate the effects of ALA on apoptotic activity in the treatment of periodontitis. Materials and methods: Thirty male Wistar rats were randomly divided into 3 groups: control (without ligature), PED (ligature + placebo, saline; oral gavage), and ALA+PED (ligature + alpha lipoic acid at 50 mg/kg/day in saline; oral gavage). Histological and biochemical analyses were performed on the mandibular first molars of sacrificed rats. Results: Biochemical myeloperoxidase activity in gingivo-mucosal tissue was measured. For immunohistochemical …

One Single-Tube Pcr Assay To Detect Both Cd17 (A>T) And Ivs-Ii Nt-654 (C>T) Homozygous Mutations Of \Beta-Thalassemia, Qi Liu, Jun-Li Wang, Guo-Can Yang, Xue-Jun Dong, Zong-Xin Wang, Guo-Xing Ge, Xiao-Feng Gu

Turkish Journal of Medical Sciences

Several methods can be used to detect gene mutations associated with \beta-thalassemia, but it is difficult to achieve reliable and reproducible results. In this study, we introduce a new method, a single-tube multiplex polymerase chain reaction (PCR) assay, to detect both CD17 (A>T) and IVS-II nt-654 (C>T) homozygous mutations. Materials and methods: This new method designs specific primers to diagnose homozygous mutations and normal controls. Results: After PCR amplification, homozygous mutations produce different fragments from normal controls. Conclusion: This study represents an important step towards the development of a novel protocol to diagnose \beta-thalassemia and other diseases that …

Prevalence Of Type 1 Diabetes Mellitus In School Children 6–18 Years Old In Diyarbakır, Southeastern Anatolian Region Of Turkey, Hüseyi̇n Demi̇rbi̇lek, Mehmet Nuri̇ Özbek

Turkish Journal of Medical Sciences

The frequency of type 1 diabetes mellitus (T1DM) differs according to factors like geographical location, ethnicity, sex, and age. There are few studies investigating T1DM prevalence in the children of Turkey or of the Southeastern Anatolian Region. We aimed to define T1DM prevalence and to investigate geographic and sociodemographic features in school children 6-18 years old living in Diyarbakır. Materials and methods: The number of children with T1DM and the total number of children at the schools were defined in cooperation with the Diyarbakır Provincial Education Directorate. T1DM prevalence was calculated with the obtained data. Results: The number of school …

The Effect Of Chloroquine Treatment In Malignant Astrocytomas On Prognosis, Turgay Bulut, Mehmet Ali̇ Eki̇ci̇, Bülent Tucer, Seyi̇t Kağan Başarslan, Kağan Kamaşak, Ali̇ Kurtsoy

Turkish Journal of Medical Sciences

To investigate the adjuvant role of the antimutagenic agent chloroquine in the treatment of patients with malignant astrocytomas (MAs). Materials and methods: Clinical research was conducted at the Neurosurgery Clinic of the Erciyes University School of Medicine, from September 2003 to April 2007, on 37 patients diagnosed with MA after tumor resection subsequent to craniotomy. Chloroquine treatment was started on a daily dose of 150 mg, additional to the patients' radiotherapy and chemotherapy protocol, and was continued throughout the 43-month surveillance period. A control group was formed of 81 patients with MA after the craniotomy. Results: While the mean survival …

Determination Of Mitochondrial Fragmentation And Autophagosome Formation In C2c12 Skeletal Muscle Cells, Saadet Türkseven, Antonio Zorzano

Turkish Journal of Medical Sciences

To investigate the effect of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on mitochondrial elimination in C2C12 skeletal muscle cells. Materials and methods: C2C12 muscle cells stably expressing Mito-DsRed were treated with DMSO or CCCP at the doses of 10, 20, and 30 µM for 3, 6, and 24 h. After specific treatments, cells were fixed in 4% paraformaldehyde and immunocytochemistry assays were performed using appropriate antibodies to evaluate mitochondrial morphology and autophagosome formation. Total cell lysates were used for western blot assays. Results: CCCP induces mitochondrial fragmentation in C2C12 cells. In response to a mitochondrial uncoupler, endogenous autophagosome formation is significantly increased …

Association Between Maternal Ghrelin Levels And Hyperemesis Gravidarum, İkbal Kaygusuz, İlknur İnegöl Gümüş, Melahat Yildirim, Hüsametti̇n Erdamar, Aysel Uysal, Serap Aynur Si̇mavli, Abdullah Ayyildiz, Muhammet Ramazan Yi̇ği̇toğlu

Turkish Journal of Medical Sciences

To investigate serum levels of ghrelin in pregnant women as a potential early marker for hyperemesis gravidarum (HG). Materials and methods: A cross-sectional study was carried out at Fatih University Hospital. Included in the study were 35 women with HG and 31 pregnant women without HG as a control group. The groups were compared in terms of age, gravidity, body mass index (BMI), and fasting serum thyroid-stimulating hormone (TSH) and ghrelin levels. Results: Ghrelin levels of the patients with HG were found to be significantly lower than those in the control group (P = 0.03). No intergroup differences could be …

Prognostic Factors In Patients With Glioblastoma Multiforme (Clinical Research), Mehmet Ali̇ Eki̇ci̇, Turgay Bulut, Bülent Tucer, Seyi̇t Kağan Başarslan, Ali̇ Kurtsoy

Turkish Journal of Medical Sciences

To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM). Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006. A total of 98 patients were diagnosed with GBM after tumor resections. Patients' demographic, neurological, radiological, surgical, and clinical features and adjunct therapies were analyzed retrospectively. Results: Of the 98 patients, 36 (36.7%) were female and 62 (65.4%) were male. There were 15 patients (15.3%) still alive. The median survival time (MST) of the gross total resection and subtotal resection …

The Effects Of Thyroid Hormones On Uroflowmetry Parameters In Asymptomatic Women, Ersi̇n Çi̇mentepe, Mehmet Erol Yildirim, İlkay Beki̇r İncebay, Ayşe Çarlioğlu, Ömer Faruk Karataş, Doğan Ünal

Turkish Journal of Medical Sciences

To investigate whether there is any association between uroflowmetry parameters and blood levels of thyroid hormones in asymptomatic women. Materials and methods: Included in the study were 110 consecutive female patients with no urinary complaints who had thyroid function tests performed in an endocrinology clinic. Uroflowmetric measurements were performed for each patient in a sitting position. The patients were divided into 3 groups, hypo-, hyper-, and euthyroidism, and were investigated for statistical difference among them regarding maximum flow rate (Qmax), average flow rate (Qave), voided volume (VV), and voiding time (VT). Results: The mean Qmax and Qave values of hypo-, …

Serum Leptin Levels And Their Proportional Relationship With Pro- And Antiinflammatory Mediators In Aggressive Periodontitis: Preliminary Report, Zuhal Yetki̇n Ay, Recep Sütcü, Havva Koçak, Fatma Yeşi̇m Kirzioğlu

Turkish Journal of Medical Sciences

To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients. Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC). The fasting venous serum samples were used to determine the OB and the cytokines/mediators belonging to the Th1/Th2/Th17 cells. The correlations among the OB and cytokines/mediators in the serum and clinical periodontal parameters were also investigated. Results: The AP group presented significantly higher serum TGF-\beta1 and IL-2 concentrations (pg/mL) and lower IL-4, IL-5, IL-12, IL-13, and IL-17A concentrations than the …