Digital Commons Network^™

Development And Survival Of Saratoga Spittlebug Nymphs On Alternate Host Plants, Louis F. Wilson, George C. Heaton, Patrick C. Kennedy

The Great Lakes Entomologist

\!hen abundant, the adult Saratoga spittlebug, Aphrophora smatogensis (Fitch), injures or kills young red pine, Pinus rerinovr Ait., and jack pine, P. banksiana Lamb. Its abundance depends greatly on the quantit). and quality of woody plants and forbs of the forest floor that senre a5 alternate hosts during the nymphal stages (Anderson, 1947; Ewan, 1961: Kennedy and Wilson, 1971; Secrest, 1944). Sweet-fern, Comptonia peregrina Coult., is the principal and most important alternate host (Kennedy and Wilson, 1971), but little is know-n about the value of other woody plants and forbs for supporting nymphal development. Therefore, \ve sought to examine the …

Parasites Of Lepidopterous Larvae In Alfalfa And Soybeans In Central Illinois, S. J. Roberts, W. K. Mellors, E. J. Armbrust

The Great Lakes Entomologist

During the 1971-72 soaing season sweep-net samples were taken to determine the major species of parasites and lepidopterous host larvae present in central Illinois soybeans and alfalfa. A trod of 27 primary Hymenoptera and Diptera parasites was collected from nine Lepidopterous species. Parasites were associated with all nine species of Ian-ae m alfalfa and soybeans. Apanteles flaviconchae Riley was responsible for over 87% of &e parasitism of Colias spp. larvae in both alfalfa and soybeans in 1971. The hyperparasites Mesochorus discitergus (Say) and M. arnericanus Cresson were recovered from fou~of dep rim= parasites Pathogens were found in six species of …

Temporomandibular Joint Osteoarthritis And Systemic Inflammation: A Cadaveric Study For Dental Insights, Nathan Kent Bs, David Patterson Bs, Alyssa Luu Bs, Samantha Pipkin Bs, Jason Ciccotelli Dpt, Phd, Jeremy James Dmd, Ms, Jessica Immonen Phd, Ms

The Journal of Integrative Physiology

The objective of this study was to determine if gross signs of cadaveric osteoarthritis (OA) have

a tendency to present systemically and if this presentation includes pathology found at the

temporomandibular joint (TMJ). Signs of OA were then correlated to gross alterations of the aorta and common carotid arteries seen with atherosclerotic cardiovascular disease. Ipsilateral synovial joints including the TMJ, knee joint, radiocarpal joint and trapeziometacarpal (TMC) joint were all assessed for signs of OA in 4 cadaveric donors (3 males; 72, 82 and 92 years-old / 1 female; 89 years-old) using a validated scale of disease severity. A Grade …

The Legal System For Influencers On Social Media Platforms: A Comparative Study, Ahmad Ibrahim Ballal, Najem Riyad Al-Rabadi, Ma’Moun Rashed Al-Huneiti

Middle East Journal of Communication Studies

This study explores the legal regulation of social media influencers through a comparative analysis between French and Jordanian legislation. The research problem lies in the absence of a clear and comprehensive legal framework regulating influencers' growing role in shaping public opinion. Using the comparative analytical method, the study examines relevant legal texts and regulatory approaches in both jurisdictions. The findings highlight significant differences, with France enacting a specific law to govern influencer activities, while Jordan still relies on general legal provisions. The study recommends drafting a dedicated Jordanian law that outlines influencers' legal responsibilities and balances freedom of expression with …

Representations Of The Other In Hamas's Media Discourse During The "Al-Aqsa Flood" Operation: A Rhetorical Analytical Study, Enad Mamdouh Al-Zaben, Sabah Al Harahsheh

Middle East Journal of Communication Studies

This study aimed to determine how the Hamas movement represented the "other" in its media discourse during the "Al-Aqsa Flood" operation. To achieve this goal, the study relied on the qualitative analytical approach, specifically rhetorical discourse analysis. The study sample included all Hamas's media spokesman speeches, between October 7, 2023, and January 1, 2024, numbering 11 speeches. The study results showed that Hamas's media discourse focused on portraying two main groups: "us" and "them." The "us" group included the Palestinian people in all their spectra. They were referred to using terms with positive connotations such as: "the steadfast," "the one …

Addressing Anxiety In The Pediatric Population: An Ot Perspective, Joshua D. Johnson, Mary Jan Greer, Wendy Tremaine, Justine Faghihifar

Summer 2025 OTD Capstone Symposium

This capstone develops and evaluates a trauma-informed training for RBTs and caregivers in outpatient ABA clinics serving children with ASD and anxiety. Grounded in MOHO, the seven-module program teaches trigger→support mapping, sensory strategies, visual tools, and brief co-regulation routines. Findings show improved knowledge and confidence, with recommendations to embed a fidelity rubric, booster sessions, and ready-to-use templates.

Examining Associations Between Street Vegetation And Child Firearm Violence At Microgeographic Locations In 3 Us Cities: A Case-Control Study, Zihan Lin, Gregory A. Wellenius, Jonathan Jay

Biological, Geological, and Environmental Faculty Publications

Background: Firearm violence is a leading cause of death among U.S. children under age 18. Urban vegetation, a vital component of the living environment, has been found to influence firearm violence, yet the relationship between different types of street vegetation and firearm violence with children as the victim at the microgeographic scale remains unclear.

Methods: We analyzed 2316 child firearm assault incidents from Los Angeles, New York City, and Philadelphia from 2015 to 2021. Using a spatial case-control approach, we matched assault locations with control locations within 1-km. For each location, we applied deep learning algorithms to Google Street View …

Global Erk/Mapk Activation Determines Oncogenic Fitness In Kras-Mutant Pancreatic Ductal Adenocarcinoma, Rachel A. Burge

MUSC Theses and Dissertations

In pancreatic ductal adenocarcinoma (PDAC), ~95% of cases harbor an activating KRAS mutation. The most common KRAS mutations in PDAC are KRAS^G12D (42%), KRAS^G12V (31%), and KRAS^G12R (15%). Patients harboring KRAS^G12R mutations have increased overall survival compared to those with KRAS^G12D/V-mutations. While KRAS^G12D/Vare common in all KRAS-mutant cancers, KRAS^G12Ris only common in PDAC.

KRAS^G12R is unable to activate the lipid kinase PIK3CA, a KRAS effector that is important for tumorigenesis in murine models. To investigate the tumorigenic potential of KRAS^G12R and the mechanisms that enable this mutation …

Preventing Injuries In Cdl Drivers: An Occupational Therapy Approach, Jerika Eumecha Arnsworth, Cassandra Nelson, Lee Ann Hoffman

Summer 2025 OTD Capstone Symposium

Commercial drivers are at heightened risk for musculoskeletal disorders (MSDs) due to prolonged sitting, inadequate ergonomic environments, and limited access to health education. This doctoral capstone project aimed to address these challenges through the development, implementation, and evaluation of a five-week educational program focused on improving ergonomic awareness and occupational health among CDL drivers. Grounded in the Person-Environment-Occupation (PEO) model, the program was implemented in collaboration with a small commercial logging company in Texas and featured weekly modules on hydration, preparatory movements, assistive technology, seating posture, and mental health.

A needs assessment revealed limited ergonomic knowledge among participants and a …

First Report Of Fibropapillomatosis And Critical Habitat Use In Green Sea Turtles In Curaçao, M. Tripepi, I. J. R. Van Veghel, A. D. Vreugdenhil, E. Brunelli

College of Life Sciences Faculty Papers

Fibropapillomatosis, a disease affecting green sea turtles (Chelonia mydas), has been documented in many regions of the world, including the Caribbean, but has not been scientifically reported in Curaçao until now. The present study utilized VHF telemetry in Caracas Bay, Curaçao, to track green sea turtles, both healthy and affected by fibropapillomatosis, with the objective of ascertaining their foraging locations. VHF telemetry proved to be a pivotal method for assessing habitat use in areas characterized by limited visibility and high boat traffic, conditions that present significant challenges for divers and snorkellers attempting to access the area. The results …

Developing Site-Specific Water Response Functions Using Historical Soil Moisture Data, Gifty Lad Ayela

Theses and Dissertations

Variable rate irrigation (VRI) systems offer a promising solution by optimizing water application based on site-specific needs in different areas within a crop field. While accurate crop water production functions (CWPFs) are essential for VRI systems, developing CWPFs has been hindered by challenges in data collection and the complexities of modeling water’s impact on yields. This study attempts to develop site-specific CWPFs using farmers’ historical soil moisture data, collected using soil water tension (SWT) as a proxy, and yield maps. The spatial variability of the crop-water response functions was modeled using Geographically Weighted Regression (GWR) and the results from this …

Modeling Diameter Distribution Of Loblolly Pine Plantations In Response To Mid-Rotation Thinning Treatments And Assing The Economic Returns In Western Gulf Coastal Plain, Pragya Rijal, Yuhui Weng, Anusha Shrestha, Jason Grogan

Electronic Theses and Dissertations

The influence of thinning regimes incorporating row thinning on diameter distribution and timber product allocation is of considerable importance in the management of loblolly pine (Pinus taeda) plantations within the Western Gulf Coastal Plain. This study utilized data from a thinning study plots established by the East Texas Pine Plantation Research Project across East Texas and Western Louisiana. A two-parameter Weibull distribution was used to model diameter distributions under varying thinning intensities, with parameter estimation conducted using both parameter prediction (PPM) and percentile-based (PRM) methods. The PRM approach demonstrated excellent model performance, with coefficients of determination (R²) ranging …

Enumerating Escherichia Coli (E. Coli) Concentrations And Evaluating Optical Brighteners As A Potential Indicator Of Human Wastewater Contamination In La Nana Bayou, Banita Creek, And Their Tributaries, Nacogdoches, Texas, Swastika Acharya, Matthew Mcbroom, Yuhui Weng, Yanli Zhang

Electronic Theses and Dissertations

La Nana Bayou was added to the Texas 303(d) list in 2000 after it failed to meet water quality standards set by the Texas Commission on Environmental Quality (TCEQ) for primary contact recreation due to elevated Escherichia coli (E. coli) levels. E. coli is a bacterial species commonly found in the intestines of humans and warm-blooded animals. It serves as an indicator of fecal contamination in freshwater, though its presence alone cannot identify the contamination source. Optical brighteners (OBs), chemicals found in laundry detergents, cleaning agents, toilet papers, and clothing, are unique to human wastewater. This study aimed …

Transcription Fidelity In The Face Of Oxidative Damage, Eastilan Gyiwah Appiah

Theses and Dissertations

It is very important that the process of transcription is correctly carried out in the cell for the faithful expression of the genetic code. However, should mistakes happen, they can result in transcription errors which interfere with the protein-making machinery of the cell. This will result in accumulation of proteins and dysfunctional proteins that have the potential of causing diseases like Alzheimer’s. Oxidative damage caused by hydrogen peroxide is known to cause transcription errors in organisms like yeast. It is therefore important to investigate the extent to which hydrogen peroxide can damage cells.

Influence Of Diverse Forage Environments On Honey Bee Colony Health, Angus Catchot Iii

Theses and Dissertations

Honey bees are important pollinators that face a multitude of stressors in their environment such as pathogens, parasite pressure, forage availability and pesticide exposure. This study examined how the makeup of different environments and the stressors related to those environments are affecting honey bee health in Mississippi. A field experiment was conducted during the first year of the study across four distinct landscapes ranging from intensively cultivated cropland to predominantly natural forage habitats to assess the impact of landscape availability on varying honey bee colony health parameters. Locations that had cultivated crops within foraging range produced more honey and brood …

Effects Of Psychological Arousal And Relaxation On Muscle Performance, Activation, And Heart Rate Variability During Maximal Muscle Strength And Precision Tasks, Allison Ann Brown

Theses and Dissertations

Psychological arousal plays a vital role in athletic performance, with the optimal point of arousal and performance level varying by task complexity. A common manipulator of arousal is music, which can produce multiple physiological effects. This study investigated whether unfamiliar arousing or relaxing music influences heart rate variability, muscle activation, maximal muscle strength, and muscle precision. Theoretically, if participants are found to have differing muscle performance responses as a result of differing music selections, this would further support the notion that the optimal point of arousal and performance is dependent upon the complexity of the task at hand. Thus, coaches …

Strategic Use Of Exogenous Feed Enzymes And Sodium Bisulfate To Optimize Broiler Production, Spencer Thomas Karn

Theses and Dissertations

Poultry producers must continually evaluate nutritional strategies to enhance broiler performance and sustainability. Chapter II assessed sodium bisulfate (SB) applied to litter, feed, and water across a 42-day grow-out. Applying SB to litter reduced pH, while 0.3% and 0.4% dietary SB improved feed conversion ratio (FCR). Water acidification with SB during the final week did not impair performance, supporting its use as a preharvest intervention. Chapter III evaluated phytase at 500, 1500, and 2000 FTU/kg, with or without protease, in reduced amino acid diets over 56 days. Birds fed a nutrient-adequate diet with 1500 FTU/kg phytase outperformed all reduced-amino acid …

From Gametes To Genes: Genetic Quality Assessment Of Anuran Cryopreserved Spermatozoa And Derived Embryos, Trinity Isabella Kassuhn

Theses and Dissertations

Sperm cryopreservation is an important tool within the suite of assisted reproductive technologies (ART) as it enables long-term storage of genetically valuable gametes. However, knowledge of the diagnostic criteria for assessing sperm quality and the genetic consequences of using cryopreserved sperm in amphibians is limited. This gap has raised concerns in captive breeding and reintroduction programs regarding the potential impact that cryopreserved sperm and the derived embryos may have on a population. The thesis aims to investigate how sperm cryopreservation affects the genetic material in both sperm and resulting embryos, with implications for in situ and ex situ amphibian populations. …

Understanding Pollinator-Forb Interactions And Evaluating Trapping Methods For Pollinator Monitoring In Lawns Of The Southeastern United States, Sara Rose Kirby

Theses and Dissertations

Urban turfgrass landscapes are widespread across the southeastern United States but offer limited ecological value under conventional management. This thesis evaluates the pollinator support potential of ten forb species commonly found in low-maintenance lawns and assesses the effectiveness of two insect sampling methods, sweep netting and pan trapping. Over two years of field surveys, native forbs such as Symphyotrichum divaricatum and Claytonia virginica supported significantly greater insect abundance and diversity than introduced species. Network and modularity analyses revealed that native plants facilitated more specialized pollinator interactions, including those involving oligolectic bee species. In a complementary study, pan traps effectively sampled …

Sweetpotato Insect Pests: Virus Vector Management And Rearing, Rachel Emily Morrison

Theses and Dissertations

Sweetpotatoes (Ipomoea batatas) are vegetatively propagated through slips, making them prone to viral buildup. Aphids are insect pests known for transmitting viruses to crops, which reduces yield. This study examined different options for aphid management to reduce the spread of potyviruses: crop borders, crop oils, and insecticides. However, the results of this research showed that treatments were not successful at reducing the spread of the four potyviruses tested. An additional objective was to establish a colony of banded cucumber beetles (Diabrotica balteata) in the laboratory. These beetles are a leaf-feeding and root-feeding pest of sweet potatoes. Two colonies of banded …

Evaluation Of Soil Steaming, Cover Crops, And Allelopathy: An Integrated And Sustainable Weed Management Strategy In Sweetpotatoes, Alaina Marie Richardson

Theses and Dissertations

Yellow nutsedge (Cyperus esculentus L.) is a persistent weed in sweetpotato and vegetable cropping systems caused by its aggressive growth habit and limited control options. The present study assessed two alternative, chemical-free methods: steaming the soil and the use of allelopathic cover crops. Greenhouse and field experiments showed that steaming suppressed the germination of yellow nutsedge effectively and that treatments for 45 min provided the highest control of all the soil depths tested (100%). A leachate experiment examined the allelopathy of five cover crops against yellow nutsedge and showed that buckwheat and cereal rye had the largest reductions in shoot …

Feed-Based Strategies To Improve Poultry Production Efficiency, Anna Kathryn Riggs

Theses and Dissertations

The poultry industry continues to make significant strides in efficiency and innovation, particularly through advancements in nutrition. This thesis explores two key areas within broiler nutrition that are essential to supporting sustainable, cost-effective poultry production. First, the potential of a next-generation exogenous carbohydrase enzyme blend containing beta-mannanase and endo-glucanase is investigated when supplemented into reduced-energy, all-vegetable diets based on corn, soybean meal, and corn distillers dried grains with solubles in male broilers over a 42-day grow-out period, including processing (Chapter II). Second, the thesis examines the use of modeling strategies such as cubic, quadratic, kernel and smoothing spline to predict …

Raspberry Cultivar Evaluation Trial In Mississippi, Apphia Santy

Theses and Dissertations

Raspberries (Rubus idaeus) are valued for their flavor, appearance, and nutritional quality. This study evaluated 26 raspberry cultivars over two seasons (2023 and 2024) in Mississippi under a 50% shade-covered system, using organic and conventional fertilization in 7-gallon containers. Cultivars included floricane- and primocane-fruiting types. Data collected included harvest timing, yield, berry weight, soluble solids content (°Brix), titratable acidity, total phenolic content (TPC), and total flavonoid content (TFC). Results showed cultivar differences in yield, berry quality, and antioxidant levels. In 2023, conventionally fertilized plants produced higher yields; in 2024, fertilizer had no impact. Late-season harvests had elevated phytochemicals. ‘Prelude,’ ‘Nova,’ …

Integrated Analysis Of Untargeted Liver, Serum Metabolome And Gut Microbiome Following Selenium Deficiency Diet In Selenoh Knockout And Wildtype Mice, Richard Eugene Baird

Theses and Dissertations

Selenoprotein H (SELENOH) is an oxidoreductase located in the nucleolus, and its biochemical levels decrease with selenium (Se) deficiency, as reported in mammalian research. This current investigation aimed to understand the impact of nutritional Se deficiency on gut microbial composition and metabolomic profiles. The Firmicutes/Bacteroidota (F/B) ratio, linked to various health conditions, was balanced for wildtype (WT) mice (1.06). In contrast, selenoh knockout (KO) mice associated with dietary Se deprivation had a significantly (p < 0.002) lower ratio (0.56), suggesting dysbiosis. It is believed that SELENOH levels decreased due to the Se deficient diet, and the selenoh KO mice exhibited alterations in microbial community composition and metabolite profiles, as supported by correlative analyses. With respect to the bacterial communities, significant differences between diets occurred for three taxa, including Akkemansia mucinphila, Bacteroides caecimuris, and Parabacteroides goldsteinii. Candida tropicalis, Malassezia restricta, and Cyberlindnera jadinii were three abundant fungal yeasts. Only Cyberlindnera jadinii exhibited significantly greater relative abundance between genotypes and was more abundant in the selenoh KO versus WT mice. Correlation analyses between bacterial and fungal taxa revealed both positive and negative relationships, but no specific trends were observed. The liver and serum metabolomic data contained similar amino acids, lipids, proteins, and carbohydrates. Using NMR spectroscopy, 112 liver metabolites were detected, while GC-TOF-MS analysis of the serum revealed the presence of 172, comprising both polar and nonpolar compounds. The metabolite levels varied significantly when analyzed using multivariate models such as PCA and PLS-DA (VIP scores), particularly for glucose, taurine, lactate, and UDP-glucose, which are associated with energy production and cellular health. Overall, the Se deficient diet had the most significant impact on the microbial community structure and the concentration of key metabolites within liver tissues and serum. Correlation analyses conducted across studies revealed significant linear relationships between metabolites and the microbiome. However, these differences were associated with bacterial and fungal taxa containing low relative abundances. Based on these findings, further investigation into the impact of SELENOH homeostasis on microbial and metabolite profiles should be conducted using selenoh KO mice under various nutritional Se dietary levels.

Impact Of Buffered Dry Vinegar And Fermented Onion Juice On The Quality And Shelf-Life Of Fresh Pork Breakfast Sausage, Emily M. Little

Theses and Dissertations

The demand for clean-label meat products has increased interest in natural alternatives to synthetic antioxidants and antimicrobials. This study evaluated the effects of buffered dry vinegar (BDV), fermented onion juice (FOJ), and their combination (CMB) on microbial stability and sensory quality of pork sausage during 9 days of refrigerated storage. Sausages were assigned to control, FOJ (0.5%), BDV (0.5%), or CMB (0.25% each) treatments. BDV and CMB significantly reduced aerobic and psychrotrophic counts by days 7-9, while yeast increased across all treatments over time, reaching ~7 Log CFU/g by day 9. Sensory analysis revealed lower oxidation and off-note intensity in …

Frontline Acalabrutinib, Lenalidomide And Rituximab For Advanced Stage Follicular Lymphoma With High Tumor Burden: Phase Ii Trial, Paolo Strati, Lei Feng, Jason R Westin, Ranjit Nair, Luis E Fayad, Maria A Rodriguez, Dai Chihara, Luis Malpica, Jared Henderson, Mariana Gallardo, Marissa Rivera, Iris Wang, Anastasiia Bolshakova, Anastasia Radko, David Kurtz, Stefan K Alig, Christopher R Flowers, Ash A Alizadeh, Sattva S Neelapu

Faculty, Staff and Student Publications

This phase II trial aims to determine the efficacy and safety of frontline acalabrutinib, lenalidomide and rituximab for patients with advanced stage follicular lymphoma (FL) and high tumor burden. The primary endpoint was best complete response (CR) rate; the secondary endpoints were overall response rate (ORR), duration of response measured as CR at 30 months (CR30), progression of disease at 24 months (POD24) rate, progression-free survival (PFS), overall survival and safety. Twenty-four patients with previously untreated FL were included in this phase 2 single arm study (NCT04404088). The most common grade 3-4 adverse events were neutropenia (58%) and …

Histologic And Immune Characterization Of Cutaneous Immune-Related Adverse Events Induced By Immune Checkpoint Inhibitors, Omar Pacha, Anisha B Patel, Jonathan L Curry, Cara L Haymaker, Nejla Ozirmak Lermi, Dzifa Yawa Duose, Ken Chen, Joud Hajjar, Aung Naing

Faculty, Staff and Student Publications

Background: Although immune checkpoint inhibitors (ICIs) are efficacious, they often cause immune-related adverse events (irAEs), most commonly cutaneous irAEs (CirAEs). The mechanisms underlying CirAEs remain unclear.

Methods: Attempting to better understand their mechanisms and histology we conducted a prospective study of 15 patients with advanced cancers treated with ICIs who developed grade 2 or higher CirAEs. Clinical and histologic characterization of biopsy specimens of CirAEs was performed. Histologic analysis of patient biopsy specimens were subdivided by epidermal reaction patterns that included spongiotic, lichenoid, and interface dermatitis patterns. A targeted RNA expression assay was used to identify immune markers in CirAE …

Acute Toxicity Of Arsenate And Arsenite In Two Scleractinian Coral Species: Acropora Cervicornis And Orbicella Faveolata, Cailey Dorman

All HCAS Student Capstones, Theses, and Dissertations

Inorganic arsenic (As), specifically arsenate (As(V)) and arsenite (As(III)) are well-documented toxicants to a range of marine organisms. However, their specific impacts on coral reef species remain largely unstudied. This study is the first to assess the acute and subacute toxicity of inorganic arsenic on two threatened scleractinian coral species, Acropora cervicornis and Orbicella faveolata. Corals were exposed for 96 hours to five analytically verified concentrations and a negative control of either arsenate or arsenite. Toxicity was evaluated through three endpoints: mortality (LC50), coral condition (EC50), and photosynthetic efficiency (IC50). The lethal concentrations to result in 50% mortality (LC50) …

The Trophic Ecology Of The Snipe Eel Avocettina Infans (Anguilliformes: Nemichthyidae) In The Deep-Pelagic Gulf Of Mexico, Emma N. Schindler

All HCAS Student Capstones, Theses, and Dissertations

The Nemichthyidae (snipe eels) are ubiquitous in the deep-pelagic waters of tropical and temperate latitudes, and in some ecosystems are among the dominant fishes. In the deep waters of the Gulf of Mexico, the nemichthyid species Avocettina infans is one of the dominant large predators. This prompted the current study, where an extensive sample set was utilized to characterize the abundance of the family in total, and the vertical distribution and trophic ecology of A. infans specifically. The nemichthyid abundance from 0 – 1500 m was estimated at 1,106.58 individuals per billion cubic meters, the largest portion of which was …

Lysosomes As Gatekeepers: How Lic1-Mediated Trafficking Regulates Angiogenesis And Vascular Morphogenesis, Dymonn Johnson

Arts & Sciences Graduate Student Theses and Dissertations

Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex that plays a critical role in cytoplasmic cargo trafficking, including Rab-mediated endosomal recycling and lysosomal degradation. LIC1 interacts with various cargo adaptors, such as RILPL1 and RILPL2, to regulate these processes, and defects in this gene are predicted to impair dynein motor function, Rab binding, and lysosomal trafficking. Here, we identified a dync1li1 zebrafish mutant with a premature stop codon at the exon 12/13 splice acceptor site, that exhibits increased angiogenesis. In vitro, LIC1-deficient human endothelial cells show elevated cell surface levels …