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Understanding Tobacco Use Among Bangladeshi Men: A Socio-Demographic Analysis Of Risk Factors, Md. Rashedus Salekin Sabbir, Helal Uddin, Md Shazid Hossain Shohan Oct 2025

Understanding Tobacco Use Among Bangladeshi Men: A Socio-Demographic Analysis Of Risk Factors, Md. Rashedus Salekin Sabbir, Helal Uddin, Md Shazid Hossain Shohan

Indonesian Journal of Public Health Nutrition (IJPHN)

Tobacco consumption remains a major public health concern in Bangladesh, where adult males represent the most affected group. Despite existing bans on public smoking, cultural norms, media influence, and limited awareness continue to sustain high prevalence. The objective of this study was to examine the socio-demographic determinants of tobacco use among Bangladeshi men, focusing on regional variation, education, media exposure, and family influence. A cross-sectional survey was conducted among 275 adult males in Dhaka Division using a structured questionnaire. Data was analyzed through descriptive statistics, chi-square tests, and binary logistic regression to identify significant predictors of tobacco consumption. Findings reveal …


Proportion Of Chronic Energy Deficiency In Relation To Macronutrient Intake And Other Determinants Among Pregnant Women In Selected Community Health Center Service Areas In Bogor 2025, Fathimah Afliansa, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Suparno Suparno Oct 2025

Proportion Of Chronic Energy Deficiency In Relation To Macronutrient Intake And Other Determinants Among Pregnant Women In Selected Community Health Center Service Areas In Bogor 2025, Fathimah Afliansa, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Suparno Suparno

Indonesian Journal of Public Health Nutrition (IJPHN)

The prevalence of chronic energy deficiency (CED) among pregnant women in Indonesia remains relatively high, ranging from 11.6% to 57.6%. This study aimed to examine the differences in the proportion of CED based on macronutrient intake and related factors. The study used a quantitative cross-sectional design with secondary data involving 124 pregnant women in selected areas served by community health centers in Bogor City and Regency. Data were analyzed using the chi-square test. CED prevalence was 11.3% in the overall areas, with 10.9% in Bogor City and 11.7% in Bogor Regency. Significant differences in the CED proportion were found based …


Safety And Efficacy Of Liver-Directed Radiotherapy After Chemoimmunotherapy For Advanced Cholangiocarcinoma: An Early Report From A Large Tertiary Cancer Center, Abdulmoiz Asif, Abdulmoid Asif, Michael K Rooney, Enoch Chang, Felicity Namayanja, Kimana Quentin, Sunyoung Lee, Ian Hu, Vincent Bernard, Prajnan Das, Emma B Holiday, Sonal Noticewala, Grace L Smith, Albert C Koong, Ethan B Ludmir, Milind Javle, Lianchun Xiao, Eugene J Koay Oct 2025

Safety And Efficacy Of Liver-Directed Radiotherapy After Chemoimmunotherapy For Advanced Cholangiocarcinoma: An Early Report From A Large Tertiary Cancer Center, Abdulmoiz Asif, Abdulmoid Asif, Michael K Rooney, Enoch Chang, Felicity Namayanja, Kimana Quentin, Sunyoung Lee, Ian Hu, Vincent Bernard, Prajnan Das, Emma B Holiday, Sonal Noticewala, Grace L Smith, Albert C Koong, Ethan B Ludmir, Milind Javle, Lianchun Xiao, Eugene J Koay

Faculty, Staff and Student Publications

BACKGROUND: Recent randomized controlled trials have established chemoimmunotherapy as the standard of care for patients with advanced biliary cancers with a median overall survival (OS) of about thirteen months. No data exist to demonstrate the safety and efficacy of liver-directed radiotherapy (RT) for extrahepatic and intrahepatic cholangiocarcinoma (CCA) in the era of chemoimmunotherapy. The purpose of this study is to report our early experience treating patients with CCA using RT and chemoimmunotherapy.

METHODS: Twenty-eight patients with CCA who received chemoimmunotherapy sequentially and/or concurrently with RT were retrospectively analyzed. The median biologic equivalent dose (BED) of RT was 84.0 [interquartile range …


Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness, Emanuele Vitale, Mila Gugnoni, Veronica Manicardi, Silvia Muccioli, Federica Torricelli, Benedetta Donati, Simonetta Piana, Gloria Manzotti, Elisa Salviato, Francesca Reggiani, Cristian Ascione, Rebecca Vezzani, Moira Ragazzi, Mattia Forcato, Oriana Romano, Silvio Bicciato, Aaron Goldman, Marco Tigano, Alessia Ciarrocchi Oct 2025

Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness, Emanuele Vitale, Mila Gugnoni, Veronica Manicardi, Silvia Muccioli, Federica Torricelli, Benedetta Donati, Simonetta Piana, Gloria Manzotti, Elisa Salviato, Francesca Reggiani, Cristian Ascione, Rebecca Vezzani, Moira Ragazzi, Mattia Forcato, Oriana Romano, Silvio Bicciato, Aaron Goldman, Marco Tigano, Alessia Ciarrocchi

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Embryonic Transcription Factors (TFs) are often reactivated in cancer, driving developmental gene programs that support phenotypic plasticity. Metabolic adaptation fuels this plasticity by supplying energy and molecular building blocks for growth. RUNX2, the master regulator of bone morphogenesis, is ectopically expressed in epithelial cancer, promoting metastasis through trans-differentiation processes like Epithelial-to-Mesenchymal Transition (EMT) and osteomimicry. By combining omics data with functional validation, we demonstrated that RUNX2 drives cancer cell metabolic rewiring by repressing mitochondrial respiration while promoting anabolic processes. We showed that RUNX2 upregulates key genes of lipid biosynthesis by regulating and cooperating with SREBP1. In vivo expression analysis in …


Detection Of Sweet Potato Feathery Mottle Virus Infection Via Remote Hyperspectral Imaging, Clayton Blake Oct 2025

Detection Of Sweet Potato Feathery Mottle Virus Infection Via Remote Hyperspectral Imaging, Clayton Blake

LSU Master's Theses

In sweetpotato, global production exceeds 90 million tons annually, yet yields are threatened by numerous pathogens, including the potyvirus sweet potato feathery mottle virus (SPFMV). Virus infections can reduce yields by 25–40%, but surveillance is hampered by asymptomatic infections and the labor-intensive nature of detection. Hyperspectral imaging (HSI), combined with machine learning (ML), offers a promising pathway to scalable, non-destructive detection; however, studies focused on virus infection in sweetpotato remain limited.

This study demonstrates the feasibility of ML-enabled HSI for SPFMV detection under greenhouse conditions via a curated spectral library of two commercial cultivars, 'Beauregard' and 'Orleans', and the biological …


Phenological Shifts In Nesting Behavior Of Leatherback Sea Turtles, Dermochelys Coriacea, Along Central And Southeastern Florida Beaches, Frank Jesse Dejohn Oct 2025

Phenological Shifts In Nesting Behavior Of Leatherback Sea Turtles, Dermochelys Coriacea, Along Central And Southeastern Florida Beaches, Frank Jesse Dejohn

USF Tampa Graduate Theses and Dissertations

Climate change is altering environmental conditions worldwide, affecting the timing and success of critical life-history events in many species. The timing of leatherback sea turtle (Dermochelys coriacea) nesting behavior is closely linked to seasonal and local environmental conditions, yet multi-decadal shifts in nesting phenology associated with climate change remain poorly understood. Using long-term leatherback nesting and saturation tagging data (2000––2025), I first examined patterns in emergence dates, emergence times per night, and the number of nesting leatherbacks per night over this 26-year period. Moreover, I examined the impact of environmental covariates including day length, water temperature, precipitation, wind speed, barometric …


The Key To Acquiring The Language Of Law, Science, And Technology In The Esl College Classroom, Patricia George-Hunter Oct 2025

The Key To Acquiring The Language Of Law, Science, And Technology In The Esl College Classroom, Patricia George-Hunter

Journal of English Learner Education

Since vocabulary plays a significant role in second language acquisition, expansive vocabulary targets should be set and pursued. This paper explores the results of introducing affixes to develop vocabulary and increase motivation for beginner to intermediate-level English language learners (ELLs) pursuing academic disciplines in law, science, and technology at a New York City community college. Participants included 23 ELLs with diverse linguistic, educational, and sociocultural backgrounds enrolled in an online synchronous Integrative Language Seminar (ILS) designed to develop all areas of English language proficiency. Pre‑, post‑, delayed tests, questionnaires, and post‑intervention interviews were conducted and analyzed to establish the language …


Exploring Stem Cell Therapies For Chronic Diseases, Ashley Thompson Oct 2025

Exploring Stem Cell Therapies For Chronic Diseases, Ashley Thompson

Trick to the Treat of Internships and Research

No abstract provided.


Research Assistant At The University Of Minnesota Advanced Research And Diagnostics Laboratory, Vishnu Vundamati Oct 2025

Research Assistant At The University Of Minnesota Advanced Research And Diagnostics Laboratory, Vishnu Vundamati

Trick to the Treat of Internships and Research

No abstract provided.


Biol 3400 Microbiology/Lab (Tiny Earth) With Dr. Garcia, Noura Naami Oct 2025

Biol 3400 Microbiology/Lab (Tiny Earth) With Dr. Garcia, Noura Naami

Trick to the Treat of Internships and Research

No abstract provided.


Mentored Structural Biology Of Human Pathogens (Msbio-Path) Summer Program, Harani Athwale Oct 2025

Mentored Structural Biology Of Human Pathogens (Msbio-Path) Summer Program, Harani Athwale

Trick to the Treat of Internships and Research

No abstract provided.


Biol 1000/1001 Introduction To Biology Research I/Ii (Sea Phages), George Vasilakis Oct 2025

Biol 1000/1001 Introduction To Biology Research I/Ii (Sea Phages), George Vasilakis

Trick to the Treat of Internships and Research

No abstract provided.


Radiofrequency Ablation Research At Worcester Polytechnic Institute, Maanya Chitrapu Oct 2025

Radiofrequency Ablation Research At Worcester Polytechnic Institute, Maanya Chitrapu

Trick to the Treat of Internships and Research

No abstract provided.


Student Athletes Abroad - Pre-Health Costa Rica, Bridget Mcgrath Oct 2025

Student Athletes Abroad - Pre-Health Costa Rica, Bridget Mcgrath

Trick to the Treat of Internships and Research

No abstract provided.


Science Alive - Stem Education Outreach, Brianna Bourke, Maggie Luo, Amaan Khan Oct 2025

Science Alive - Stem Education Outreach, Brianna Bourke, Maggie Luo, Amaan Khan

Trick to the Treat of Internships and Research

No abstract provided.


Md Anderson University Outreach, Sanjana Ananthula, Tulsi Desai Oct 2025

Md Anderson University Outreach, Sanjana Ananthula, Tulsi Desai

Trick to the Treat of Internships and Research

No abstract provided.


Summer 2025 Surgical Internship At The Medical University Of Graz, Caroline Rodriguez Chang, Rochelle Avezki, Irene Murathe Oct 2025

Summer 2025 Surgical Internship At The Medical University Of Graz, Caroline Rodriguez Chang, Rochelle Avezki, Irene Murathe

Trick to the Treat of Internships and Research

No abstract provided.


Discover Eden Ecology Internship, South Africa, Daphne De Sedas, Gabriella Flora, Reagan Spahr Oct 2025

Discover Eden Ecology Internship, South Africa, Daphne De Sedas, Gabriella Flora, Reagan Spahr

Trick to the Treat of Internships and Research

No abstract provided.


Analyzing The Implications Of Artificial Intelligence (Ai) For Active Learning And Assessment Globally In Healthcare And Stem, Vinay Munlapudi, Santanu De Oct 2025

Analyzing The Implications Of Artificial Intelligence (Ai) For Active Learning And Assessment Globally In Healthcare And Stem, Vinay Munlapudi, Santanu De

Trick to the Treat of Internships and Research

No abstract provided.


Optometric Internship For Biol4950: Eyes On Southern, Ella Weinlick Oct 2025

Optometric Internship For Biol4950: Eyes On Southern, Ella Weinlick

Trick to the Treat of Internships and Research

No abstract provided.


Investigating The Impacts Of Microplastics On Bacterial Community Dynamics In Mangrove Sediments, Al Maha Sulaiman Alshamsi Oct 2025

Investigating The Impacts Of Microplastics On Bacterial Community Dynamics In Mangrove Sediments, Al Maha Sulaiman Alshamsi

Thesis/ Dissertation Defenses

Microplastic (MP) pollution poses a growing threat to global ecosystems, particularly in coastal habitats like mangroves, which serve as vital carbon sinks. This study investigates the specific impacts of polypropylene (PP), polyethylene terephthalate (PET), and adipic acid (AA) on microbial community assembly in mangrove sediments, with a focus on sequential arrival of different MPs. Based on MP identity, early arrival of specific MP before others can significantly impact microbial community composition and their functioning. However, the impacts of the sequential arrival of MPs on microbial communities have never been studied. This research fills this important knowledge gap by using novel …


Major Drivers Of Consumer Choice Of Dairy Milk And Plant-Based Milk Alternatives In Coffee, Uyen Thuy Xuan Phan, Luu Hoang, Keith Weber, Anuradha Prakash Oct 2025

Major Drivers Of Consumer Choice Of Dairy Milk And Plant-Based Milk Alternatives In Coffee, Uyen Thuy Xuan Phan, Luu Hoang, Keith Weber, Anuradha Prakash

Food Science Faculty Articles and Research

Coffee shops in the United States typically offer several options of dairy milk and plant-based milk alternatives (PBMA) for espresso-based beverages. Although previous studies have explored consumer preferences for dairy or PBMA in general, none have examined what drives their milk or PBMA choices specifically in the context of coffee shops. This study aimed to identify key decision drivers for the choice of milks in coffee, assess the role of lactose-free preferences, and explore whether offering lactose-free cow milk would increase coffee shop visits. Following a preliminary study using in-depth interviews, an online survey was used to collect data from …


Effective Control Of Tomato Leaf Miner, Tuta Absoluta (Meyrick) (Lepidoptera: Gelechiidae) Using The Entomopathogenic Fungus, Beauveria Pseudobassiana Rehner & Humber In Commercial High-Arched Plastic Tunnels, Aya Fardoun, Nour Ezzeddine, Hagop S. Atamian, Hana Sobh, Houssam Shaib, Yusuf Abou Jawdah Oct 2025

Effective Control Of Tomato Leaf Miner, Tuta Absoluta (Meyrick) (Lepidoptera: Gelechiidae) Using The Entomopathogenic Fungus, Beauveria Pseudobassiana Rehner & Humber In Commercial High-Arched Plastic Tunnels, Aya Fardoun, Nour Ezzeddine, Hagop S. Atamian, Hana Sobh, Houssam Shaib, Yusuf Abou Jawdah

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background

The tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is a highly invasive pest that causes significant damages to tomato crops globally. Its resistance to commonly used chemical insecticides has made management increasingly difficult, prompting the need for sustainable, effective alternatives. This study investigated the efficacy of a Lebanese isolate of Beauveria pseudobassiana as a biological control agent against T. absoluta, compared its performance to Bacillus thuringiensis and conventional pesticide mixtures under both controlled, commercial production conditions

Results

Three preliminary cage experiments were conducted under controlled infestation conditions using larvae reared from field-collected adults. Conidial suspensions of B. pseudobassiana …


Understanding The Effects Of Real-Time Head Position Feedback On Postural Sway In Terms Of Changes In Underlying Deterministic And Stochastic Dynamical Processes, Steven J. Harrison, Benjamin De Bari, Ryan Poutre, Jeffrey M. Kinsella-Shaw Oct 2025

Understanding The Effects Of Real-Time Head Position Feedback On Postural Sway In Terms Of Changes In Underlying Deterministic And Stochastic Dynamical Processes, Steven J. Harrison, Benjamin De Bari, Ryan Poutre, Jeffrey M. Kinsella-Shaw

College of Humanities and Sciences Faculty Papers

Our perceptual systems detect information about how our body is moving relative to the surrounding environment. Such information is essential to our ability to maintain upright standing balance. Real-time postural feedback systems are technologies that appear to enhance our ability to detect information about the movements of our body, and as a consequence improve our capacity to control the posture of our body. Here we examine a system in which real-time measurements of head position were "felt" as changes in the intensity of vibration of tactors in a headband. Using this system, participants were able to stabilize their body posture, …


Erratum To <[Transplant Cell Ther 2023 Jul;29(7):438e1-438e16 Epub 2023 Mar 9]>, Melissa R Hines, Tristan E Knight, Kevin O Mcnerney, Mark B Leick, Tania Jain, Sairah Ahmed, Matthew J Frigault, Joshua A Hill, Michael D Jain, William T Johnson, Yi Lin, Kris M Mahadeo, Gabriela M Maron, Rebecca A Marsh, Sattva S Neelapu, Sarah Nikiforow, Amanda K Ombrello, Nirav N Shah, Aimee C Talleur, David Turicek, Anant Vatsayan, Sandy W Wong, Marcela V Maus, Krishna V Komanduri, Nancy Berliner, Jan-Inge Henter, Miguel-Angel Perales, Noelle V Frey, David T Teachey, Matthew J Frank, Nirali N Shah Oct 2025

Erratum To <[Transplant Cell Ther 2023 Jul;29(7):438e1-438e16 Epub 2023 Mar 9]>, Melissa R Hines, Tristan E Knight, Kevin O Mcnerney, Mark B Leick, Tania Jain, Sairah Ahmed, Matthew J Frigault, Joshua A Hill, Michael D Jain, William T Johnson, Yi Lin, Kris M Mahadeo, Gabriela M Maron, Rebecca A Marsh, Sattva S Neelapu, Sarah Nikiforow, Amanda K Ombrello, Nirav N Shah, Aimee C Talleur, David Turicek, Anant Vatsayan, Sandy W Wong, Marcela V Maus, Krishna V Komanduri, Nancy Berliner, Jan-Inge Henter, Miguel-Angel Perales, Noelle V Frey, David T Teachey, Matthew J Frank, Nirali N Shah

Faculty, Staff and Student Publications

No abstract provided.


Final Analysis Of The Resonate-2 Study: Up To 10 Years Of Follow-Up Of First-Line Ibrutinib Treatment For Cll/Sll, Jan A Burger, Paul M Barr, Tadeusz Robak, Carolyn Owen, Alessandra Tedeschi, Anita Sarma, Piers E M Patten, Sebastian Grosicki, Helen Mccarthy, Fritz Offner, Edith Szafer-Glusman, Cathy Zhou, Anita Szoke, Lynne Neumayr, James P Dean, Paolo Ghia, Thomas J Kipps Oct 2025

Final Analysis Of The Resonate-2 Study: Up To 10 Years Of Follow-Up Of First-Line Ibrutinib Treatment For Cll/Sll, Jan A Burger, Paul M Barr, Tadeusz Robak, Carolyn Owen, Alessandra Tedeschi, Anita Sarma, Piers E M Patten, Sebastian Grosicki, Helen Mccarthy, Fritz Offner, Edith Szafer-Glusman, Cathy Zhou, Anita Szoke, Lynne Neumayr, James P Dean, Paolo Ghia, Thomas J Kipps

Faculty, Staff and Student Publications

With up to 10 years of follow-up, we report results from the final analysis of RESONATE- 2, a phase 3 study of first-line ibrutinib vs chlorambucil for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Patients aged ≥65 years with previously untreated CLL/SLL without del(17p) were randomly assigned to receive either single-agent ibrutinib (420 mg/d; n = 136) or chlorambucil (0.5-0.8 mg/kg; ≤12 cycles; n = 133). With a median follow-up of 9.6 years in the ibrutinib arm, the median progression-free survival (PFS) was 8.9 years (95% confidence interval [CI], 7.0 to not estimable [NE]) vs 1.3 years (95% …


Nmr Spectroscopy-Derived Index For The Nutritional Assessment Of Extra Virgin Olive Oils Based On Fatty Acids Profiling, Charlotte E. Rowley, Zora Singh, Andrea Steck, Birk Schuetz, Manfred Spraul, Henry Brockman, Yimin Wang, Catherine Itsiopoulos, Jeremy K. Nicholson, Samantha Lodge, Elaine Holmes, Gary Frost, Andres Bernal, Ruey Leng Loo Oct 2025

Nmr Spectroscopy-Derived Index For The Nutritional Assessment Of Extra Virgin Olive Oils Based On Fatty Acids Profiling, Charlotte E. Rowley, Zora Singh, Andrea Steck, Birk Schuetz, Manfred Spraul, Henry Brockman, Yimin Wang, Catherine Itsiopoulos, Jeremy K. Nicholson, Samantha Lodge, Elaine Holmes, Gary Frost, Andres Bernal, Ruey Leng Loo

Research outputs 2022 to 2026

The nutritional benefits of Extra Virgin Olive Oils (EVOOs) depend on their chemical composition. Currently, there is no simple way to compare the health benefits of different EVOOs based on their fat profiles. Samples from Australia and four Mediterranean countries (N = 423) were analyzed using proton nuclear magnetic resonance spectroscopy to screen for six quality parameters (free acidity, peroxides, K270, K232, Delta K, wax) and to measure fat compositions. These fat compositions were compared against healthy eating guidelines to produce five binary descriptors, which were weighted by evidence to create an accessible Fatty Acid based Nutrition Index (FNI). EVOOs …


Cohesin Haploinsufficiency Is Tolerated In Cbfb::Myh11-Driven Murine Acute Myeloid Leukemia, Shannon E Conneely, Alexis Quezada, Kristen J Kurtz, Nenggang Zhang, Josephine De La Fuente, Nesa Mercer, Jason H Rogers, Rogelio Aguilar, Geraldo Medrano, Margaret A Goodell, Paul P Liu, Debananda Pati, Rachel E Rau Oct 2025

Cohesin Haploinsufficiency Is Tolerated In Cbfb::Myh11-Driven Murine Acute Myeloid Leukemia, Shannon E Conneely, Alexis Quezada, Kristen J Kurtz, Nenggang Zhang, Josephine De La Fuente, Nesa Mercer, Jason H Rogers, Rogelio Aguilar, Geraldo Medrano, Margaret A Goodell, Paul P Liu, Debananda Pati, Rachel E Rau

Faculty, Staff and Students Publications

Cohesin gene mutations occur in many malignancies, including acute myeloid leukemia (AML). Loss-of-function mutations in the four major cohesin complex genes (RAD21, SMC3, SMC1a, and STAG2) occur across most major genetic subtypes of AML but are notably absent in AML harboring CBFB::MYH11, suggesting that cohesin mutations yield distinct biological outcomes dependent on the genetic AML driver. We hypothesized that CBFB::MYH11-expressing leukemias would be dependent on intact cohesin genes given their near-mutual exclusivity. To investigate this, we combined either germline or inducible heterozygous deletions in cohesin genes Smc3 or Rad21, respectively, with an inducible murine model of Cbfb::MYH11 AML. This approach …


Integrating Microbial Communities With Above- And Below-Ground Carbon And Multispectral Satellite Data In Mangrove Forests, Huda Ahmed Alshalan Oct 2025

Integrating Microbial Communities With Above- And Below-Ground Carbon And Multispectral Satellite Data In Mangrove Forests, Huda Ahmed Alshalan

Thesis/ Dissertation Defenses

Mangrove ecosystems are vital blue carbon sinks increasingly threatened by human activities and climate change, especially in arid, hypersaline regions. This study examines Avicennia marina, the dominant UAE mangrove species, recognized for its significant carbon retention capability0. Its biomass and stability are influenced by sediment chemistry, and bacterial diversity and community structure which drive nutrient cycling and organic matter decomposition—key processes sustaining soil fertility and carbon sequestration. Remote sensing enables large-scale assessment of mangrove distribution and density, but single spectral indices often miss ecological variability in the fragmented UAE mangrove habitats. Combining multiple spectral indices with field data improves detection, …


Rebound Bursting Selectively Enables Fast Dynamics In Dopamine Midbrain Neurons Projecting To The Dorsolateral Striatum, Strahinja Stojanovic, Christopher J. Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin, Stephan Lammel, Carmen C. Canavier, Jochen Roeper Oct 2025

Rebound Bursting Selectively Enables Fast Dynamics In Dopamine Midbrain Neurons Projecting To The Dorsolateral Striatum, Strahinja Stojanovic, Christopher J. Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin, Stephan Lammel, Carmen C. Canavier, Jochen Roeper

School of Graduate Studies Faculty Publications

Dopamine (DA) midbrain neurons are involved in a wide array of key brain functions including movement control and reward-based learning. They are also critical for major brain disorders such as Parkinson's disease or schizophrenia. DA neurons projecting to distinct striatal territories are diverse with regard to their molecular makeup and cellular physiology, which are likely to contribute to the observed differences in temporal DA dynamics. Among these regions, the dorsolateral striatum (DLS) displays the fastest DA dynamics, which might control the moment-to-moment vigor and variability of voluntary movements. However, the underlying mechanisms for these DLS-specific fast DA fluctuations are unresolved. …