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Articles 4051 - 4080 of 256548
Full-Text Articles in Entire DC Network
Winner's Curse Free Robust Mendelian Randomization With Summary Data, Zhongming Xie, Wanheng Zhang, Jingshen Wang, Chong Wu
Winner's Curse Free Robust Mendelian Randomization With Summary Data, Zhongming Xie, Wanheng Zhang, Jingshen Wang, Chong Wu
Faculty, Staff and Student Publications
In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR analyses, incorporating genetic variants as instrumental variables, are known for their robustness against reverse causation bias and unmeasured confounders. Nevertheless, classical MR analyses using summary data may still produce biased causal effect estimates due to the winner’s curse and pleiotropy issues. To address these two issues and establish valid causal conclusions, we propose a unified robust Mendelian Randomization framework with summary data, which systematically removes the winner’s curse and screens out invalid genetic instruments with pleiotropic effects. …
Electric Pressure Cookers: What You Need To Know, Callahan Adams, Emily Smith
Electric Pressure Cookers: What You Need To Know, Callahan Adams, Emily Smith
All Current Publications
Electric pressure cookers (EPCs) offer convenience, versatility, and efficiency in everyday cooking. EPCs offer multiple cooking functions beyond pressure cooking, including sautéing, slow cooking, steaming, cooking rice, and preparing yogurt. They are not suitable for pressure canning, as confirmed by multiple Extension research studies and national guidelines. When used properly, EPCs provide a safe and effective way to prepare meals quickly while saving counter and storage space.
Eepd1 Evolved A Unique Dna Clamping Dimer Protecting Reversed Replication Forks, Runze Shen, Altaf H Sarker, Yue Chen, Min Liu, Sunetra Roy, Andrew S Arvai, Albino Bacolla, Zamal Ahmed, Panagiotis Katsonis, Michal Hammel, Isao Kuraoka, Miaw-Sheue Tsai, Corydon Irie, Lukas Webb, Olivier Lichtarge, Chi-Lin Tsai, Susan E Tsutakawa, Katharina Schlacher, John A Tainer
Eepd1 Evolved A Unique Dna Clamping Dimer Protecting Reversed Replication Forks, Runze Shen, Altaf H Sarker, Yue Chen, Min Liu, Sunetra Roy, Andrew S Arvai, Albino Bacolla, Zamal Ahmed, Panagiotis Katsonis, Michal Hammel, Isao Kuraoka, Miaw-Sheue Tsai, Corydon Irie, Lukas Webb, Olivier Lichtarge, Chi-Lin Tsai, Susan E Tsutakawa, Katharina Schlacher, John A Tainer
Faculty, Staff and Student Publications
Exonuclease/endonuclease/phosphatase (EEP)-fold hydrolases are canonically monomeric phosphodiesterases exemplified by APE1, DNase I, and TDP2 nucleases. While EEP family domain containing protein 1 (EEPD1) acts in DNA stress responses, its proposed nuclease activities are enigmatic. Here, we integrate hybrid structural methods, evolution, biochemistry, cancer genomics, plus molecular and cell biology to define EEPD1 structure, assembly, and function at stalled DNA replication forks. Results imply EEPD1 surprisingly requires both unique EEP domain dimer and distinctive tandem Helix-hairpin-Helix [(HhH)2] domains to clamp double-stranded (ds) DNA at reversed DNA replication forks for fork protection. Small-angle X-ray Scattering (SAXS), crystal, and cryo-EM structures unveil an …
Reliability And Score Agreement Of A Modified Lower Quarter Y-Balance Test As Compared To The Lower Quarter Y-Balance Test In Healthy Adults, Braden L. Lawson, Jordan Morris, Alan Brubaker Rodriguez, Wendy Wheeler
Reliability And Score Agreement Of A Modified Lower Quarter Y-Balance Test As Compared To The Lower Quarter Y-Balance Test In Healthy Adults, Braden L. Lawson, Jordan Morris, Alan Brubaker Rodriguez, Wendy Wheeler
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction: The Y-Balance Test (YBT) is a dynamic balance test assessing range of motion, flexibility, neuromuscular control, and strength. The YBT is used to evaluate individuals for increased injury risk, deficiencies, and progress of rehabilitation. Due to the higher cost associated with materials in a YBT kit, a modified YBT (mYBT) was created using three cloth measuring tapes, and three blocks of wood to help mitigate financial barriers. In previous studies the mYBT has demonstrated adequate agreement of composite scores with the Upper Quarter Y-Balance Test (UQYBT). The purpose of this study was to determine the agreement of composite scores …
The Effect Of Vitamin D Supplementation On Serum 25(Oh)D And Its Association With Stress Fractures In High-Risk, Physically Active Adults: A Critically Appraised Topic, Connor Lewis, Martha Yost, Aric J. Warren
The Effect Of Vitamin D Supplementation On Serum 25(Oh)D And Its Association With Stress Fractures In High-Risk, Physically Active Adults: A Critically Appraised Topic, Connor Lewis, Martha Yost, Aric J. Warren
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Clinical Scenario: In collegiate athletic and military populations alike, the repetitive and intense training increase the risk of experiencing a stress fracture, representing a significant time loss and financial cost. Research suggests the use of supplemental vitamin D to prevent the occurrence of stress fractures in high-risk adults. Clinical Question: In high risk, physically active adults, does the effect of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentration effect the occurrence of stress fractures? Clinical Bottom Line: The findings suggest that clinicians should consider the use of supplemental vitamin D as a protective measure against the occurrence of stress …
A Comparison Of Novel Treatment Interventions To Improve Hamstring Range Of Motion, Sadie Buboltz-Dubs, Brittney Dejong, William S. Gear
A Comparison Of Novel Treatment Interventions To Improve Hamstring Range Of Motion, Sadie Buboltz-Dubs, Brittney Dejong, William S. Gear
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Purpose: Perceived hamstring tightness is a prevalent condition caused by multiple factors, including anterior pelvic tilt and neural tension. Traditional treatments, such as static stretching, do not address these underlying conditions. This study aimed to determine the short-term effectiveness of two neuromuscular treatment techniques for increasing hamstring flexibility compared with a traditional static stretching technique. Methods: Hamstring range of motion was measured using PSLR and AKE pre-and post-intervention for two treatment sessions and again as a single discharge measurement one week after the first treatment session. Three treatments were studied: Primal Reflex Release Technique, Neurodynamic Sliding Technique, Static Stretching, …
Effects Of Functional Ankle Instability On Muscle Activation Latency In Ice Hockey Athletes: A Pilot Study, Nicolas Gonzalez, Tyler A. Wood, Nicholas E. Grahovec
Effects Of Functional Ankle Instability On Muscle Activation Latency In Ice Hockey Athletes: A Pilot Study, Nicolas Gonzalez, Tyler A. Wood, Nicholas E. Grahovec
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
This study examined lower extremity muscle activation latency during the push-off phase in ice hockey athletes with and without functional ankle instability (FAI). Ten athletes participated, divided into FAI and control groups based on the Identification of Functional Ankle Instability scale. Participants completed three push-off trials while wearing electromyography sensors on the tibialis anterior, fibularis longus, medial gastrocnemius, and gluteus medius. The FAI group demonstrated a significant increase in muscle activation latency across all muscles tested (p
Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar
Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar
Turkish Journal of Biology
Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …
Population Satisfaction Indicators Of The Quality-Of-Life Standards During The Work Trip (A Case Study Of The Cities Of Minia And New Minia), Shimaa Mohammed Hamdy Derbala, Amna Waz Amgad Ali
Population Satisfaction Indicators Of The Quality-Of-Life Standards During The Work Trip (A Case Study Of The Cities Of Minia And New Minia), Shimaa Mohammed Hamdy Derbala, Amna Waz Amgad Ali
Mansoura Engineering Journal
The research examined the indicators of population satisfaction with the quality of life during work trips in the cities of Minia and New Minia, in relation to the problem of low urban communication between the two cities and the continued dependence of debtors on each other to provide employment opportunities. The research examined previous studies linking the quality of life of work trips to the environmental, social and psychological aspects of the movement and economy, A questionnaire was designed for a sample of the population (388 individuals) to assess the residents' impression of the quality of life during their work …
Role Of Piezo1 Channels Expressed In Pvn In Regulating Sympathetic Nerve Activity And Arterial Blood Pressure In Rats, Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory Miodonski, Enshe Jiang, Qing Hui Chen, Yi Yang, Renjun Wang
Role Of Piezo1 Channels Expressed In Pvn In Regulating Sympathetic Nerve Activity And Arterial Blood Pressure In Rats, Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory Miodonski, Enshe Jiang, Qing Hui Chen, Yi Yang, Renjun Wang
Michigan Tech Publications
Mechanosensitive Piezo1 channels participate in regulating pain sensitivity, insulin secretion, and vascular tension; however, their expression in the autonomic paraventricular nucleus (PVN) and role in modulating sympathetic outflow and cardiovascular function remain unstudied. In this study, unilateral PVN microinjection of the Piezo1 channel blocker Dooku1 (0.1, 1, 10, 100, and 200 pmol) administered to anesthetized male rats increased renal sympathetic nerve activity (RSNA) and mean artery pressure (MAP) in a dose-dependent manner, with maximum increases of 93 ± 30% (p < 0.0001) and 21 ± 5 mmHg (p < 0.0001), respectively, elicited by Dooku1 at 100 pmol. Similarly, PVN microinjection of the peptide Piezo1 channel blocker GsMTx4 (1 nmol) significantly increased RSNA (p < 0.001) and MAP (p < 0.0001). Conversely, PVN-microinjected Piezo1 channel activators Yoda1 (5 nmol) and Jedi2 (5 nmol) did not significantly alter RSNA or MAP. Western blot and qRT-PCR analyses of the hypothalamic PVN showed abundant Piezo1 mRNA and protein expression. Immunofluorescence detection showed that Piezo1 was expressed in pre-sympathetic PVN neurons with axons projecting to the rostral ventrolateral medulla. We conclude that Piezo1 channels expressed in the autonomic PVN neurons play an important role in regulating sympathetic outflow and cardiovascular function.
Isolated Bacillus Licheniformis Sp01 From Daqing Oilfield In Reducing Chromium(Iii) Crosslinked Polymer Residue And Enhancing Oil Recovery, Xiao Hui
Student Works (2020-2029)
After polymer gel formation, the residual partially hydrolyzed polyacrylamide (HPAM) and the crosslinker (Cr3+) caused plugging and decreased oil recovery. Microorganisms can degrade HPAM to address the issues, but Cr³⁺ inhibits the process and reduces oil recovery. This study explores the underexamined biodegradation of HPAM and improved oil recovery in the presence of Cr³⁺, offering new perspectives for microbial enhanced oil recovery (MEOR) after polymer gel formation. HPAM and crude oil were innovatively used as the sole nitrogen(N) and carbon(C) sources to isolate the best-growing strain from Daqing Oilfield produced water, identified as Bacillus licheniformis SP01. The oil displacement potential …
Innovative Approaches For Lung Cancer Screening And Interception, Jianjun Zhang, Matthew D Park, Tej Pandya, Elaine Shum, Jia Wu, Simon Heeke, Ramin Salehi-Rad, Thomas U Marron, Zhubo Wei, Hui Li, Torsten G Blum, John V Heymach, Steven M Dubinett, Pan-Chyr Yang, Charles Swanton, Miriam Merad
Innovative Approaches For Lung Cancer Screening And Interception, Jianjun Zhang, Matthew D Park, Tej Pandya, Elaine Shum, Jia Wu, Simon Heeke, Ramin Salehi-Rad, Thomas U Marron, Zhubo Wei, Hui Li, Torsten G Blum, John V Heymach, Steven M Dubinett, Pan-Chyr Yang, Charles Swanton, Miriam Merad
Faculty, Staff and Student Publications
Lung cancer remains the leading cause of cancer-related deaths worldwide, partly because many patients are diagnosed at late stages, highlighting the urgent need for effective early detection and intervention strategies. Low-dose computed tomography (LDCT)-based screening reduces lung cancer mortality in high-risk populations defined by age and smoking history; however, the uptake of LDCT remains low among eligible individuals. Compounding this issue, modelling studies estimate that nearly half of lung cancers occur in individuals who do not meet eligibility criteria for LDCT-based lung cancer screening under current guidelines. Moreover, LDCT-based screening has inherent limitations, including a high rate of false-positive results …
Supt16h-Associated Neurodevelopmental Disorder And Neurocristopathy: Genetic And Phenotypic Spectrum, Eunhye Lee, Seungmin Sim, Hee-Jung Choi, Eugene Y Liang, Carolyn Le, Roya Bina, Ryan Cohen, Elizabeth George, Soo Yeon Kim, Gifty Bhat, Erin Falsey, Richard Sidlow, Kristin Clinard, Shay Ben-Shachar, Eleina England, Beatriz Menendez, Isabella Herman, Shelly Nielsen, Jaya Punetha, Priya Bhola, J Austin Hamm, Megan A Keeney, Nike Sitzman, Sara Berger, Lakshmi Mehta, Alison J Conn, Lilian Downie, Myla Ashfaq, Hope Northrup, Ange-Line Bruel, Sylvie Odent, Justin O Szot, Noelia Nunez Martinez, Sunju Park, Julie Refkin, Jean-Marc Good, Fabienne Maurer, Cédric Le Caignec, David J Coman, Erin Anderson, Linda J Richards, Ryan J Dean, Caleb Yang, Chulwon Choi, Byung Joon Hwang, Jin Sook Lee, William B Dobyns, Murim Choi, Elliott H Sherr, Jong-Hee Chae, Yun Kee, Emanuela Argilli
Supt16h-Associated Neurodevelopmental Disorder And Neurocristopathy: Genetic And Phenotypic Spectrum, Eunhye Lee, Seungmin Sim, Hee-Jung Choi, Eugene Y Liang, Carolyn Le, Roya Bina, Ryan Cohen, Elizabeth George, Soo Yeon Kim, Gifty Bhat, Erin Falsey, Richard Sidlow, Kristin Clinard, Shay Ben-Shachar, Eleina England, Beatriz Menendez, Isabella Herman, Shelly Nielsen, Jaya Punetha, Priya Bhola, J Austin Hamm, Megan A Keeney, Nike Sitzman, Sara Berger, Lakshmi Mehta, Alison J Conn, Lilian Downie, Myla Ashfaq, Hope Northrup, Ange-Line Bruel, Sylvie Odent, Justin O Szot, Noelia Nunez Martinez, Sunju Park, Julie Refkin, Jean-Marc Good, Fabienne Maurer, Cédric Le Caignec, David J Coman, Erin Anderson, Linda J Richards, Ryan J Dean, Caleb Yang, Chulwon Choi, Byung Joon Hwang, Jin Sook Lee, William B Dobyns, Murim Choi, Elliott H Sherr, Jong-Hee Chae, Yun Kee, Emanuela Argilli
Faculty, Staff and Student Publications
SUPT16H encodes a subunit of the FACT (FAcilitates Chromatin Transcription) complex, a histone chaperone essential for maintaining chromatin integrity during transcription, replication, and DNA repair. Pathogenic de novo SUPT16H missense variants have previously been linked to neurodevelopmental disorders in eight individuals. Here, we expand the genotypic and phenotypic spectrum by identifying 24 additional individuals harboring ultrarare heterozygous missense or truncating variants, who share overlapping clinical features including intellectual disability, autism spectrum disorder, hypotonia, and characteristic craniofacial dysmorphism. To elucidate the underlying mechanisms, we generated a supt16h knockout zebrafish model using CRISPR/Cas9. The supt16h loss-of-function (LOF) model recapitulated key patient phenotypes …
Vines In The Landscape: Goldflame Honeysuckle, Saroj Burlakoti, Youping Sun, Shital Poudyal
Vines In The Landscape: Goldflame Honeysuckle, Saroj Burlakoti, Youping Sun, Shital Poudyal
All Current Publications
Goldflame honeysuckle is a moderately growing vine with a mature height of 10–15 feet and can spread around 3–6 feet in a single growing season. It grows well on fences, arbors, and trellises; however, canopy coverage is usually sparse and may not be suitable as a privacy screen. The vine grows well in full sun and well-drained soil, attracting hummingbirds and butterflies throughout the blooming season. It is hardy in USDA zones 5–9. Unlike Japanese honeysuckle (L. japonica), Goldflame honeysuckle is non-invasive and does not aggressively spread by runners.
Role Of Developmental Plasticity In Tethered Flight Performance Of The Oriental Fruit Fly, Bactrocera Dorsalis (Hendel) (Diptera: Tephritidae), Thabang P. Moropa, Steve B.S. Baleba, Christopher W. Weldon
Role Of Developmental Plasticity In Tethered Flight Performance Of The Oriental Fruit Fly, Bactrocera Dorsalis (Hendel) (Diptera: Tephritidae), Thabang P. Moropa, Steve B.S. Baleba, Christopher W. Weldon
All Peer-Reviewed Publications
This study investigated the effect of nutrition on development of wings and adult body condition of Bactrocera dorsalis (Hendel), an exotic pest of Asian origin and a species of economic importance in South Africa. Six host fruit types were used to rear B. dorsalis: mango, guava, orange, grapefruit, papaya and apple. One day after emergence, adults were used for tethered flight assessments using computerised flight mills. Additional flies were assessed in terms of wing morphology using geometric morphometrics, flight muscle mass, and lipid content. There were significant differences in the larval and pupal developmental time as well as larval and …
Strategies For Sustainable And Inclusive Outdoor Wayfinding In Healthcare Facilities: An Approach To Enhance User Experience At Kafr Alsheikh University Hospital, Egypt, Rania Abd Allateef Ghanam, Ahmed Salah El-Deep
Strategies For Sustainable And Inclusive Outdoor Wayfinding In Healthcare Facilities: An Approach To Enhance User Experience At Kafr Alsheikh University Hospital, Egypt, Rania Abd Allateef Ghanam, Ahmed Salah El-Deep
Mansoura Engineering Journal
Outdoor wayfinding plays a critical role in shaping user experience in healthcare environments, where inadequate navigation can heighten stress and hinder timely access to care. Despite the presence of wayfinding systems in many hospitals, outdoor navigation remains underexamined and inconsistently addressed in design guidelines. This study fills this gap by investigating architectural strategies to enhance outdoor wayfinding and reduce user stress. The research focuses on Kafrelsheikh University Hospital in Egypt and applies a twophase methodology: (1) a comprehensive literature review to identify current principles, guidelines, and best practices in outdoor wayfinding, and (2) an on-site case study to assess existing …
The Impact Of Integrating Social Benefit Requirements For Urban Green Infrastructure And Place Identity Attributes To Enhance The Sense Of Place - Case Study Of Central Park, Madinaty, New Cairo City, Egypt, Ibrahim Magdi Mohammed, Rehab Abdelfatah Abdel Aziz Mahmoud
The Impact Of Integrating Social Benefit Requirements For Urban Green Infrastructure And Place Identity Attributes To Enhance The Sense Of Place - Case Study Of Central Park, Madinaty, New Cairo City, Egypt, Ibrahim Magdi Mohammed, Rehab Abdelfatah Abdel Aziz Mahmoud
Mansoura Engineering Journal
This research develops an integrated model that links the social benefit requirements of Urban Green Infrastructure (UGI) with the non-physical attributes of Place Identity (PI) to enhance the Sense of Place (SOP) in contemporary urban environments. The need for this integration arises from limitations in current planning frameworks, which often prioritize ecological performance while overlooking cultural, perceptual, and behavioral dimensions that shape user attachment and belonging. The study adopts an inductive and synthesis-based approach to identify key UGI indicators across environmental, social, economic, and spatial dimensions, alongside PI attributes related to places’ legibility, uniqueness, publicness and territoriality, place’s identification. To …
Enhancing Thermal Energy Storage Efficiency Using Optimized Concrete Materials: A Review, Ahmed Mohamed Abbass, Ahmed M. El-Khayatt, Khaled A. Eltawil
Enhancing Thermal Energy Storage Efficiency Using Optimized Concrete Materials: A Review, Ahmed Mohamed Abbass, Ahmed M. El-Khayatt, Khaled A. Eltawil
Mansoura Engineering Journal
The increasing global energy demand and the environmental impact of fossil fuels necessitate the development of sustainable energy solutions. Solar energy is a promising alternative, but its intermittency and inefficiency limit its widespread adoption. This study explores the role of advanced concrete-based thermal energy storage systems in addressing these challenges. Key aspects examined include packing density optimization, high-temperature performance, and hydrothermal durability of concrete. The research highlights the importance of granulometric optimization, binder selection, and hydration mechanisms in enhancing concrete properties. Additionally, the effects of heat exposure on concrete durability, permeability, and mechanical strength are analyzed, with a focus on …
Optimized Thermal Management Of Cylindrical Lithium-Ion Batteries Using Circular Fins And Forced Air-Cooling, Mohamed M. Donia, Ahmed A. Hegazi, Mohamed A. Aziz, Osama Abdelrehim
Optimized Thermal Management Of Cylindrical Lithium-Ion Batteries Using Circular Fins And Forced Air-Cooling, Mohamed M. Donia, Ahmed A. Hegazi, Mohamed A. Aziz, Osama Abdelrehim
Mansoura Engineering Journal
The Battery Thermal Management System (BTMS) is vital for maintaining the optimal performance, safety, and longevity of electric vehicle batteries by keeping their temperature within a desired range. This study proposes an optimized cooling solution for BTMS based on both experimental and numerical investigations. Experimental tests were performed on a single battery cell under discharging rates of 1C, 2C, 3C, and 4C using an electronic load, with thermal performance evaluated under natural convection. Numerical models simulating both forced and natural convection were developed using ANSYS 19.3, and a combined Computational Fluid Dynamics (CFD) and Response Surface Methodology (RSM) approach was …
Verification Of Offline Signature Based On A Hybrid Dense-Attention-Residual-Cnn Structure Optimized By Grey Wolf Algorithm, Zeyad T. Salim, Mahmoud M. Saafan, Eman M. El-Gendy
Verification Of Offline Signature Based On A Hybrid Dense-Attention-Residual-Cnn Structure Optimized By Grey Wolf Algorithm, Zeyad T. Salim, Mahmoud M. Saafan, Eman M. El-Gendy
Mansoura Engineering Journal
Signature verification is a necessary vision task with prevalent use in securing realworld applications. Offline signature is a popular type that needs to efficacious approach to be checked due to the depending on the paper time and the written tool. The progress in intelligent algorithms participates in supporting simple way authentication-based signatures. In this research work, an offline signature verification (OSV) based on an optimized and costumed convolutional neural network(CNN) infrastructure is suggested. The CNN is costumed by integrating residual, dense, and attention mechanisms, then optimized by applying a grey wolf optimization(GWO) algorithm. The system is trained and tested with …
The Impact Of The Podcast "Climate, What's The Story?" On The Jordanian Public's Awareness Of Climate Change, Amnaa Abushammaleh
The Impact Of The Podcast "Climate, What's The Story?" On The Jordanian Public's Awareness Of Climate Change, Amnaa Abushammaleh
Middle East Journal of Communication Studies
The study aimed to identify the extent to which the Jordanian public follows climate change through the podcast "Climate, What's Its Story?" and the reasons for this follow-up, in addition to revealing the extent of their confidence in the information presented about climate change in the podcast "Climate, What's Its Story?" and the reasons for this confidence. It also aimed to identify the level of awareness of the Jordanian public about climate change after listening to the studied podcast, in addition to measuring the extent of the Jordanian public's interaction with the information presented in it, the forms of this …
The Role Of Motion Graphics In Enhancing The Effectiveness Of Infographics Design, Hussein Mohammad Al-Omari
The Role Of Motion Graphics In Enhancing The Effectiveness Of Infographics Design, Hussein Mohammad Al-Omari
Middle East Journal of Communication Studies
An infographic's primary objective is to satisfy the demands and expectations of its audience by presenting information in a logical and intelligible way. Recent developments in graphic design techniques have made several intricate techniques approachable by artists and designers, elevating the design process to a sophisticated profession that transcends media boundaries. Static infographics and animated infographics feature the same material; however, animated infographics have the benefit of displaying information via continuous motion and animated sequences rather than in static components or separate stages, and that’s because of the special features of animation, which attract a wider audience. They are also …
Selenium-Thioredoxin Axis Contributes To Ferroptosis Resistance In Pancreatic Cancer Cells, Arslan Amer, Micah Olamide Idowu, Aqsa Ahsan, Alyssa A. Abbas, Tahiyat Alothaim, Xiaohu Tang
Selenium-Thioredoxin Axis Contributes To Ferroptosis Resistance In Pancreatic Cancer Cells, Arslan Amer, Micah Olamide Idowu, Aqsa Ahsan, Alyssa A. Abbas, Tahiyat Alothaim, Xiaohu Tang
Michigan Tech Publications
Pancreatic ductal adenocarcinoma (PDAC) shows substantial heterogeneity in cysteine dependence and ferroptosis sensitivity. We identify two PDAC subtypes distinguished by EMT status: mesenchymal-like cells are highly cysteine-dependent and rapidly undergo ferroptosis upon cystine deprivation or system xc− inhibition, whereas epithelial-type cells are ferroptosis-resistant. Selenium supplementation protects cells from erastin-induced ferroptosis, and this protection persists even when intracellular glutathione (GSH) is depleted, supporting an additional GPX4-independent protective mechanism. Sepp1 knockdown does not alter sensitivity, indicating that selenium’s protective effect is independent of Sepp1. Instead, epithelial-type cells rely on both cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) to maintain ferroptosis …
Effect Of Feeding Levels With High Micronutrients On The Reproductive Performance And Plasma Progesterone Concentration In Early Gestation Sows, Kewalin Kongngern, Liang-Chou Hsia, Shu-Ping Su, Wantamas Jantasin, Jai-Wei Lee
Effect Of Feeding Levels With High Micronutrients On The Reproductive Performance And Plasma Progesterone Concentration In Early Gestation Sows, Kewalin Kongngern, Liang-Chou Hsia, Shu-Ping Su, Wantamas Jantasin, Jai-Wei Lee
The Thai Journal of Veterinary Medicine
This experiment investigated the effect of feeding levels with high micronutrients on the reproductive performance and plasma progesterone concentration in early gestation sows. Thirty-six first-parity sows (Landrace × Yorkshire × Duroc), with an initial average body weight of 160.85 kg, were randomly allocated to four dietary treatments during early gestation: Treatment 1) fed 1.5 kg/day (days 1-30), Treatment 2) fed 1.5 kg/day with 1.7 times the vitamins and minerals (total vitamin E 150 IU) (days 1-15) and fed 1.5 kg/day (days 16-30), Treatment 3) fed 1.5 kg/day with 1.7 times the vitamins and minerals (total vitamin E 150 IU) (days …
From Waste To Sustainability: Exploring Consumer Purchase Intentions Of Milk Enriched With Upcycled Peanut Skins, Peng Lu, Fan Xu, Jennifer Waldeck, Keith Weber, Hualu Zhou
From Waste To Sustainability: Exploring Consumer Purchase Intentions Of Milk Enriched With Upcycled Peanut Skins, Peng Lu, Fan Xu, Jennifer Waldeck, Keith Weber, Hualu Zhou
Communication Faculty Articles and Research
Highlights
- National survey investigated consumer acceptance of milk enriched with upcycled peanut skins.
- Developed a conceptual model based on Technology Acceptance Model.
- Identified that consumer attitudes and emotions are essential in the purchase intentions of upcycled foods.
- Identified social influence as a determinator of consumers' attitudes and purchase intentions.
- Inform and advance research, practice, and policy that promotes upcycled food products.
Increased Neuronal Activity Restores Circadian Function In Drosophila Models Of C9orf72-Als/Ftd, Sho Inami, Benjamin P. Jenny, Oghenerukevwe Akpoghiran, Sara I. Gallagher, Alexandra K. Strich, Ayako Tonoki, Davide Trotti, Aaron R. Haeusler, Kyunghee Koh
Increased Neuronal Activity Restores Circadian Function In Drosophila Models Of C9orf72-Als/Ftd, Sho Inami, Benjamin P. Jenny, Oghenerukevwe Akpoghiran, Sara I. Gallagher, Alexandra K. Strich, Ayako Tonoki, Davide Trotti, Aaron R. Haeusler, Kyunghee Koh
Farber Institute for Neuroscience Faculty Papers
Circadian rhythm disruptions are common across neurodegenerative diseases, but their link to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. The C9orf72 hexanucleotide repeat expansion is the most prevalent genetic cause of ALS/FTD. Here, we used Drosophila models expressing pathogenic arginine-rich dipeptides (PR or GR) or GGGGCC hexanucleotide repeats to investigate circadian deficits in C9orf72-ALS/FTD. We found that circadian rhythmicity and period length were altered in a repeat number-, dosage-, expression pattern-, and age-dependent manner. Additionally, we observed lower levels of the neuropeptide PDF, a key regulator of free-running circadian rhythms, as well as decreased projection complexity and …
Identification Of Berbamine Hydrochloride As A Novel Coagulation Factor Vii Inhibitor By Natural Product Library Screening Using Zebrafish As A Model, Jyotheeswaran Panapakam, Jillian Via, Ambarish Kumar, Ritu Adhikary, Edgar M. Elizondo, Jabila Mary, Rajeev Azad, Art Groven, Pubur Jagadeeswaran
Identification Of Berbamine Hydrochloride As A Novel Coagulation Factor Vii Inhibitor By Natural Product Library Screening Using Zebrafish As A Model, Jyotheeswaran Panapakam, Jillian Via, Ambarish Kumar, Ritu Adhikary, Edgar M. Elizondo, Jabila Mary, Rajeev Azad, Art Groven, Pubur Jagadeeswaran
Faculty Publications - Biological Sciences
Current antithrombotic drugs cause gastrointestinal and intracranial hemorrhage and interact with dietary components and other medications. Thus, there is a need for alternative antithrombotic drugs that have fewer side effects. We screened 547 natural products (NPs) for lethality and found 321 NPs were non-lethal to zebrafish larvae. Laser-induced venous thrombosis on larvae incubated with 321 NPs identified 76 NPs with prolonged time to occlusion of the vessel (TTO). Out of these, 43 were already identified platelet inhibitors and the remaining 33 NPs were tested using laser-induced arterial, ferric chloride-induced, and phenylhydrazine-induced thrombosis assays. Of the 33 NPs tested, 4 prolonged …
Social Support And Mental Toughness As Predictors Of Perceived Stress Among College Kinesiology Students, Jianmin Guan, Wan Xiang Yao, Xiaofen D. Hamilton, Gaofeng Lu
Social Support And Mental Toughness As Predictors Of Perceived Stress Among College Kinesiology Students, Jianmin Guan, Wan Xiang Yao, Xiaofen D. Hamilton, Gaofeng Lu
International Journal of Physical Activity and Health
Drawing on Lazarus and Folkman’s transactional theory of stress and coping, this study examined the associations of age, gender, three types of social support (family, friends, and significant others), and mental toughness with two dimensions of perceived stress (helplessness and coping inefficacy) among 666 college students majoring in Kinesiology. Hierarchical multiple regression analysis revealed that male college students, as well as those with higher levels of mental toughness and family support, reported significantly lower levels of helplessness and coping inefficacy in managing stress. Additionally, greater support from friends was significantly associated with lower levels of coping inefficacy, while younger students …
Gender Differences In College Students’ Physical Activity Self-Efficacy, Social Comparison Beliefs, And External Frames Of Reference, Ken Murfay, Sarah Pyszczynski, Sarah Collins
Gender Differences In College Students’ Physical Activity Self-Efficacy, Social Comparison Beliefs, And External Frames Of Reference, Ken Murfay, Sarah Pyszczynski, Sarah Collins
International Journal of Physical Activity and Health
This study examined whom college-aged individuals believe observing would more likely increase their physical activity self-efficacy (PASE) for a physical skill, whom they are more likely to compare their abilities to within a physical education (PE) class, how often they compare themselves to others in PE, and what students’ PASE scores were. Based on the mean scores for each question, students were more likely to compare themselves to a student than a teacher, friend than a non-friend, and similar or higher skilled peer than a lower skilled peer. To increase students’ confidence for a physical skill, students had higher levels …