Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 3211 - 3240 of 256532

Full-Text Articles in Entire DC Network

Anti-Inflammatory And Insulin-Modulating Effects Of Tithonia-Curcuma-Moringa (Tcm) Formulation In Type 2 Diabetes: An Experimental Study In Mice, Rif’Atul Hawani Burhan, Nabila Shafa Yumna Salsabila, Devita Zulfa Pratama, La Tazkia Aulia Wibowo, Yulian Ervin Maulana, Moh Dliyauddin, Noviana Dwi Lestari, Agung Pramana Warih Marhendra, Aris Soewondo, Hideo Tsuboi, Muhaimin Rifa’I Apr 2026

Anti-Inflammatory And Insulin-Modulating Effects Of Tithonia-Curcuma-Moringa (Tcm) Formulation In Type 2 Diabetes: An Experimental Study In Mice, Rif’Atul Hawani Burhan, Nabila Shafa Yumna Salsabila, Devita Zulfa Pratama, La Tazkia Aulia Wibowo, Yulian Ervin Maulana, Moh Dliyauddin, Noviana Dwi Lestari, Agung Pramana Warih Marhendra, Aris Soewondo, Hideo Tsuboi, Muhaimin Rifa’I

Karbala International Journal of Modern Science

Type 2 diabetes is a chronic metabolic disorder characterized by hyperglycemia and chronic inflammation. This study investigated the anti-inflammatory and insulin-modulating effects of Tithonia-Curcuma-Moringa (TCM) formulation in type 2 diabetes model. Male BALB/c mice were divided into six groups: normal control, type 2 diabetes control, metformin treatment, and three TCM formulation treatment groups with three different dose combinations. Type 2 diabetes was induced using a high-fat diet combined with streptozotocin injection, supported by sucrose administration. After 21 days of treatment, the spleen and pancreas were isolated for flow cytometry analysis. The results showed that the expression levels of …

Go to article

Literature Review Of Local Culture-Based Mathematics E-Module With Islamic Values In Probability, Maya Puspita Sari, Surya Sari Faradiba Apr 2026

Literature Review Of Local Culture-Based Mathematics E-Module With Islamic Values In Probability, Maya Puspita Sari, Surya Sari Faradiba

Jurnal Pendidikan Sains

This study is grounded in the need to address the limitations of probability learning that is often procedural, decontextualized, and disconnected from students’ cultural and religious values. It aims to develop a comprehensive understanding of how local cultural contexts and Islamic values can be systematically integrated into mathematics e-modules, particularly for probability learning, and to formulate structured design principles and quality indicators for their development. This paper adopts a Systematic Literature Review (SLR) approach by analyzing empirical studies published between 2020 and 2025, using a structured selection process involving identification, screening, eligibility, and inclusion stages. A total of 11 high-quality …

Go to article

The Effect Of Virtual Laboratories On Students Interest And Learning Outcomes In Spermatophyta At Sma Negeri 1 Sojol, Ismawati Ismawati, Sutrisnawati Sutrisnawati, Manap Trianto, Masrianih Masrianih, Abd Rauf, Musdalifah Nurdin Apr 2026

The Effect Of Virtual Laboratories On Students Interest And Learning Outcomes In Spermatophyta At Sma Negeri 1 Sojol, Ismawati Ismawati, Sutrisnawati Sutrisnawati, Manap Trianto, Masrianih Masrianih, Abd Rauf, Musdalifah Nurdin

Jurnal Pendidikan Sains

Limited access to physical laboratory facilities and the abstract nature of Spermatophyta material reduce students’ learning interest and outcomes, necessitating the use of innovative digital learning media such as virtual laboratories. This study aims to analyze the effect of Virtual Laboratory (V-Lab) implementation on students’ learning interest and cognitive learning outcomes in Spermatophyta material at the senior high school level. A quantitative quasi-experimental design with a posttest-only control group was employed involving 66 eleventh-grade students divided into experimental and control classes; data were collected using a learning interest questionnaire and a multiple-choice test, and analyzed using independent samples t-test after …

Go to article

Reading Literacy Research Trends In Science Learning (2015–2025), Siwi Handayani, Siswanto Siswanto, Rina Rahayu Apr 2026

Reading Literacy Research Trends In Science Learning (2015–2025), Siwi Handayani, Siswanto Siswanto, Rina Rahayu

Jurnal Pendidikan Sains

This study aims to analyze research trends in reading literacy within science learning from 2015 to 2025 through a Systematic Literature Review (SLR) following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework. The initial screening of 150 articles from the WoS Core Collection and SINTA databases yielded 29 articles that met the inclusion criteria. The analysis focused on publication dynamics, contributing countries, participant characteristics, research variables, and the science subjects investigated. The findings indicate that research on reading literacy in science learning remains limited and shows fluctuating development. Most publications originate from national journals indexed by SINTA, …

Go to article

Exposure To Manganese During Juvenile Development Increases Microglial Activation In The Hippocampus Following Systemic Infection With A/California/04/2009 Influenza A H1n1 Virus, Megan Hager, Adam Schuller, Omar Yanouri, Collin Bantle, Richard Smeyne, Ronald Tjalkens Apr 2026

Exposure To Manganese During Juvenile Development Increases Microglial Activation In The Hippocampus Following Systemic Infection With A/California/04/2009 Influenza A H1n1 Virus, Megan Hager, Adam Schuller, Omar Yanouri, Collin Bantle, Richard Smeyne, Ronald Tjalkens

Farber Institute for Neuroscience Faculty Papers

Up to 80% of patients with Parkinson’s Disease (PD) develop dementia within 20 years of diagnosis. Although the etiology of PD and related neurodegenerative disorders is poorly understood, risk factors including environmental toxicants and viral infections are linked to disease onset and progression. Exposure to high doses of the essential element, manganese (Mn), causes neurotoxicity associated with parkinsonian symptoms and cognitive impairment in humans. Additionally, epidemiologic studies indicate that viral infections increase risk of developing PD. Previously, our lab demonstrated that mice exposed to Mn during juvenile development showed greater neuroinflammatory changes in microglia within the substantia nigra following systemic …

Go to article

Breaking Barriers: Advancement Toward Practical Nursing Licensure For Certified Medication Assistants In Long-Term Care--A Descriptive Study, Aleshia L. Maxwell Apr 2026

Breaking Barriers: Advancement Toward Practical Nursing Licensure For Certified Medication Assistants In Long-Term Care--A Descriptive Study, Aleshia L. Maxwell

ATU Theses and Dissertations 2021 - Present

The persistent nursing shortage across the United States, particularly in Long-Term Care (LTC) settings, has complicated the healthcare system’s ability to meet the needs of an aging population. While existing research often examines progression from Licensed Practical Nurse (LPN) to Registered Nurse (RN), limited research explores factors influencing progression from entry-level LTC healthcare workers to Practical Nursing (PN) licensure. This quantitative descriptive study examined the barriers and supporting factors influencing advancement toward PN licensure for Medication Assistants-Certified (MA-Cs) in Arkansas LTC facilities. A convenience sample of N=100 participated in the study. Results indicated that financial and structural barriers often …

Go to article

Florence State Prepares For Jet Age Needs With New, Expanded Facilities, Tommy Hill Apr 2026

Florence State Prepares For Jet Age Needs With New, Expanded Facilities, Tommy Hill

Documents

News article from The Birmingham News about the expanded facilities at Florence State College

Go to article

Construction Projects Picking Up At Una Again, Jennifer Edwards Apr 2026

Construction Projects Picking Up At Una Again, Jennifer Edwards

Documents

Demolition of Floyd Hall and other talk of new construction for The University of North Alabama

Go to article

Location Set For Una Science Building, Bernie Delinski Apr 2026

Location Set For Una Science Building, Bernie Delinski

Documents

Talk on new Science building at The University of North Alabama

Go to article

Scientist Floyd Retires At Florence State, Jack Bridges Apr 2026

Scientist Floyd Retires At Florence State, Jack Bridges

Documents

Dr. Homer H. Floyd's retirement from Florence State College

Go to article

Understanding Local Ecological Context Through Historic And Contemporary Vegetation Maps, Ray L. Brunner Apr 2026

Understanding Local Ecological Context Through Historic And Contemporary Vegetation Maps, Ray L. Brunner

Institute for Natural Resources Publications

Oregon's historic vegetation map represents patterns of vegetation prior to widespread EuroAmerican settlement and subsequent land use changes. This map is based on General Land Office surveys from 1851 – 1910 and 1930s timber mapping and serves as a valuable resource to help understand historical context and potential vegetation. Over the past few hundred years, the vegetation composition and land cover of the Oregon and the Willamette Valley have been significantly altered, with wholesale conversion of prairies and riparian woodlands to agriculture and development and encroachment of woody vegetation in the absence of fire. Presented at the 2026 LIVE conference …

Go to article

Designing Life Science Assessments In The Era Of Generative Artificial Intelligence, Andrew C. Kwong, Christopher Magnano, Christine Goglia, Joseph J. Loparo, John J. Peters Apr 2026

Designing Life Science Assessments In The Era Of Generative Artificial Intelligence, Andrew C. Kwong, Christopher Magnano, Christine Goglia, Joseph J. Loparo, John J. Peters

Biology Faculty Publications

Generative artificial intelligence (GAI) algorithms have the potential to reshape education. Though GAI may help democratize access to education, it also presents many challenges for educators. Already, the ease of use of GAI has made it easier for students to bypass learning gains by prompting GAI for answers to assignments. Here, we assessed how ChatGPT performed on take-home assignments in a doctoral-level molecular biology course designed to train students in experimental design. Using Bloom’s taxonomy as a framework, we hypothesized that ChatGPT would perform similarly to doctoral students on lower cognitive levels involving memorization and underperform at higher levels that …

Go to article

Screening Biostimulants To Enhance Early Growth Of Tomato (Solanum Lycopersicum L.) Under Water-Limited Conditions, Claudia Garrido-Ruiz, James Frisby, Amita Kaundal, Youping Sun, Milena Maria Tomaz De Oliveira Apr 2026

Screening Biostimulants To Enhance Early Growth Of Tomato (Solanum Lycopersicum L.) Under Water-Limited Conditions, Claudia Garrido-Ruiz, James Frisby, Amita Kaundal, Youping Sun, Milena Maria Tomaz De Oliveira

Plants, Soils, and Climate Faculty Publications

Biostimulants offer a sustainable strategy to improve plant growth and stress resilience, particularly under limited water availability. We evaluated seven biostimulant treatments, including beneficial bacteria, mycorrhizal fungi, seaweed extract with humic acid, and their combinations, on early growth and physiological responses of tomato (Solanum lycopersicum L.) under well–watered and drought-stressed conditions. Plants were assessed before and after a seven-day controlled drought period using a range of morphological and physiological traits, including height, effective quantum yield of PSII (ΦPSII), stomatal conductance (gs), and leaf pigment profile. Results showed that microbial treatments that included Bacteria + …

Go to article

Cytokinesis And Dbf2, Katharine Gray Apr 2026

Cytokinesis And Dbf2, Katharine Gray

Miners Solving for Tomorrow Research Conference

The Mitotic Exit Network (MEN) is a signaling pathway that allows a dividing cell to exit cytokinesis. Dbf2 is a MEN protein kinase in yeast, which provides a simplified model for studying this pathway. By altering Dbf2’s activity through phosphorylation mutants, its effect on cytokinesis can be studied. Transformed cells with a mutant and degron Dbf2 allele are prompted to destroy the degron Dbf2 protein, leaving only mutated Dbf2 behind. This allows for clear analysis of the effect of the phosphorylation mutant on division. Fluorescence microscopy can be used to visualise this degradation, and the impact on actin ring formation …

Go to article

The Stability Study Of Dna-Polymer Hybrids For Nanotechnology Applications, Ethan Kuehn, Milan Jebaraj Apr 2026

The Stability Study Of Dna-Polymer Hybrids For Nanotechnology Applications, Ethan Kuehn, Milan Jebaraj

Miners Solving for Tomorrow Research Conference

DNA nanostructures have garnered increasing interest in their application as drug delivery vehicles. However, DNA is susceptible to degradation under physiological conditions. To remedy this, we have devised a novel method to coat DNA nanostructures with the polysaccharide chitosan (a natural derivative of chitin). Chitosan binds to DNA electrostatically and inhibits nuclease activity that would normally degrade DNA in a physiological environment. We used both agarose gel electrophoresis (AGE) and atomic force microscopy (AFM) to determine the stability of DNA before and after immersion in a simulated biological environment. Physiological conditions were mimicked by incubating the DNA in cell culture …

Go to article

The Effects Of Preventing Dephosphorylation Of Lqg1 On Cytokinesis, Jenna Mueller Apr 2026

The Effects Of Preventing Dephosphorylation Of Lqg1 On Cytokinesis, Jenna Mueller

Miners Solving for Tomorrow Research Conference

Iqg1 plays crucial roles in cytokinesis, including the assembly, contraction, and disassembly of the actomyosin ring, as well as the coordination of contraction and septation. Given that cytokinesis must occur post-mitosis, Iqg1 is regulated by the cell cycle. This study explores hypotheses regarding Iqg1 regulation: it’s binding to action is negatively influenced by the cyclin-dependent kinase (CDK) Cdc28 and positively influenced by dephosphorylation via Cdc14. Newly developed yeast degron tagged strains allow for rapid depletion of specific proteins. Iqg1 mutations that alter serine to threonine, which allows phosphorylation but not dephosphorylation, in the degron strain allow testing of mutant phenotypes. …

Go to article

Biosensors For Biomedicine, Drake O'Leary Apr 2026

Biosensors For Biomedicine, Drake O'Leary

Miners Solving for Tomorrow Research Conference

This project investigated the use of engineered bacterial reporter systems to detect cellular stress responses associated with antibiotic activity. While constructs were successfully introduced and tested against known antibiotics, the reporter consistently produced a blue signal across conditions, limiting the ability to distinguish specific stress responses. This suggests issues such as leaky expression, insufficient regulatory control, or lack of specificity in the reporter design. Although results were inconclusive, this work highlights key challenges in developing reliable biosensors and provides a foundation for future optimization. Improving signal specificity and reducing background expression will be critical for enabling accurate characterization of antibiotic …

Go to article

Optimizing Duckweeds Harvesting Strategies To Maximize Nutrient Recovery And Its Role As A Phytosensor In Different Water Sources While Maximizing Sustainable Biomass Growth, Basma Ghannam Apr 2026

Optimizing Duckweeds Harvesting Strategies To Maximize Nutrient Recovery And Its Role As A Phytosensor In Different Water Sources While Maximizing Sustainable Biomass Growth, Basma Ghannam

Thesis/ Dissertation Defenses

This thesis is concerned with determining the optimal water treatment and harvesting strategy for Lemna minor duckweed plants. The main objective of this thesis is to examine how duckweed plants grow in terms of biomass, photosynthetic activity, leaf morphology, chlorophyll and carotenoid content, and their efficiency in nutrient removal from different water sources. The methodology of the study included assessing duckweed in three water samples including tap water, saline water, and greywater and three harvesting strategies, including low, medium, and high harvesting intensities to determine their growth and nutrient removal efficiency. The results of the study showed that L.minor grown …

Go to article

Asphalt Pavement Rejuvenation Investigated By Nuclear Magnetic Resonance Relaxometry, Catherine Skaggs Apr 2026

Asphalt Pavement Rejuvenation Investigated By Nuclear Magnetic Resonance Relaxometry, Catherine Skaggs

Miners Solving for Tomorrow Research Conference

Asphalt is a relatively inexpensive material commonly used for road pavements; however, asphalt ages from exposure to oxygen and UV radiation, leading to loss of elasticity, which leads to cracks and potholes. To slow or reverse asphalt aging, pavement preservation treatments are in use. It’s unclear whether these treatments truly rejuvenate the pavement structure or merely offer a short-term benefit. Nuclear Magnetic Resonance (NMR) relaxometry is an analytical technique that uses the recovery of excited nuclear magnetization as a parameter to gain insights into molecular environments. Recovery-time distributions gathered from asphalt materials show differences between regular and rejuvenated asphalt samples, …

Go to article

Validating Endosomal Antibodies For Use In Immunofluorescence Assays In A Cell-Based Model Of Prader Willi Syndrome, Hayden O'Dell Apr 2026

Validating Endosomal Antibodies For Use In Immunofluorescence Assays In A Cell-Based Model Of Prader Willi Syndrome, Hayden O'Dell

Miners Solving for Tomorrow Research Conference

Prader-Willi syndrome (PWS) is a rare progressive metabolic disease characterized by a wide range of behavioral and cognitive defects, most notably severe hyperphagia. The disorder is caused by the complete loss of some paternally inherited genes on chromosome 15q11-q13, resulting in endocrine dysfunction and a loss of control over feeding behaviors. Among the deleted genes within this region is MAGEL2. Our lab recently characterized a paternally deficient MAGEL2 rat model of PWS, discovering a defect in pituitary secretory capacity that is consistent with the impaired vesicular trafficking and secretion observed in PWS patients. To further characterize the defects in vesicular …

Go to article

Community Dynamics In Urban Ponds Could Be Influenced By Artificial Habitats, Keagan Miller, Uma Adrianna Misra Apr 2026

Community Dynamics In Urban Ponds Could Be Influenced By Artificial Habitats, Keagan Miller, Uma Adrianna Misra

Miners Solving for Tomorrow Research Conference

Urban ponds are subject to nutrient influxes from stormwater runoff, and blooms of harmful algae can develop in response. One management strategy includes deployment of Floating Treatment Wetlands (FTWs) or floating mats of aquatic plants designed to maximize uptake of nutrients to plant biomass. An understudied component of these artificial systems is their potential to provide microhabitat for aquatic biota. This study focused on the intersection of aquatic insect communities and fish presence between natural and artificial habitat types. Insect communities were found to be weakly dissimilar between habitat types (ANOSIM: R=0.254, p=0.048). Specifically, Anisoptera and Zygoptera were absent or …

Go to article

An Overview Of Herpetofauna Surveys At Fort Leavenworth Military Reserve., Zane Smith, Sandra Guzman-Duran Apr 2026

An Overview Of Herpetofauna Surveys At Fort Leavenworth Military Reserve., Zane Smith, Sandra Guzman-Duran

SACAD: Scholarly Activities

Herpetofauna surveys focused on Crayfish Frog, Spring Peeper, Eastern Tiger Salamander, Red-Bellied Snake, and Smooth Earth Snake were conducted concurrently with Bush Honeysuckle removal projects on the Fort Leavenworth Military Reservation.  Survey techniques included coverboard arrays, adaptive hunt drift fences, traditional pit fall traps and visual encounter surveys and were conducted between May and August in 2024 and 2025. The survey effort resulted in the detection of one of the target species, the Smooth Earth Snake. Based on our survey results we are confident that the Crayfish frog and Spring Peeper do not occur on Fort Leavenworth Military Reserve, but …

Go to article

Investigating The Role Of Sk-3 Interval I401 In Gene Drive By Neurospora Spore Killer-3, Alexandra Spriggs Apr 2026

Investigating The Role Of Sk-3 Interval I401 In Gene Drive By Neurospora Spore Killer-3, Alexandra Spriggs

Senior Theses – Biological Sciences

Neurospora crassa is a fungus that has been used to study genetics, more specifically, meiotic gene drive through its spore killing abilities. Meiotic drive describes a process in which selfish genetic elements bias Mendelian genetics to increase transmission to their offspring, eliminating any alleles that are sensitive. The spore killing mechanism of Neurospora’s Spore killer-3 (Sk-3) is an example of how meiotic drive works through a poison-antidote model. The Sk-3 genetic element consists of both a killing (poison) gene and a resistance (antidote) gene. The location of the resistance gene has been identified while the killing gene has not. To …

Go to article

Investigating The Role Of Interval I402 On Sk-3-Based Spore Killing And Gene Drive In Neurospora Crassa, Ellana Tobin Apr 2026

Investigating The Role Of Interval I402 On Sk-3-Based Spore Killing And Gene Drive In Neurospora Crassa, Ellana Tobin

Senior Theses – Biological Sciences

Neurospora crassa is a useful model organism for genetic research due to its haploid life cycle and its ability to produce large numbers of sexual spores called ascospores. The haploid ascospores form within asci, which typically contain eight ascospores at maturity. However, selfish genetic elements known as meiotic gene drivers have been discovered in Neurospora fungi, and some of these alter the number of viable ascospores that form in each ascus. There are two known meiotic gene drivers in N. crassa: Spore killer-2 (Sk-2) and Spore killer-3 (Sk-3). Spore killing occurs when a killer strain mates with a sensitive …

Go to article

Structural Changes In Western Australia's Sheep Industry: Regional Patterns And Producer Adaptations, Tafesse Estifanos, Kate Pritchett, Kevin Foster, Amir Abadi Abadi Ghadim, Ross Kingwell Apr 2026

Structural Changes In Western Australia's Sheep Industry: Regional Patterns And Producer Adaptations, Tafesse Estifanos, Kate Pritchett, Kevin Foster, Amir Abadi Abadi Ghadim, Ross Kingwell

Animal production and livestock published reports

Western Australia's (WA) sheep industry has undergone substantial structural transformation since the 1990s, with a 67% reduction in the flock, from 38.4 million in 1989-90 to 12.7 million in 2020-21. This transformation process followed the collapse of the Reserve Price Scheme for wool in 1991. This report examines the spatial and temporal changes in flock size, composition, and producer adaptation strategies from 2010-11 to 2020-21, drawing on Australian Bureau of Statistics (ABS) census data and Meat and Livestock Australia (MLA) and Australian Wool Innovation (AWI) producer surveys data.

Go to article

The Effects Of Climate Change On Competition And Recovery From Disturbance In An Iconic Marine Community, Lauren Tibbits Apr 2026

The Effects Of Climate Change On Competition And Recovery From Disturbance In An Iconic Marine Community, Lauren Tibbits

Senior Theses

This paper explores how the recovery of populations of Semibalanus balanoides is affected by climate variation. In intertidal marine ecosystems, larval recruitment is important in shaping all ecological processes. S. balanoides is a cold-water barnacle species that is competitively dominant over Chthamalus montagui and C. stellatus, two warm-water species. This competitive interaction is well studied, though it is not understood how that competition influences the recovery of S. balanoides after a disturbance nor how this process varies over a temperature gradient. 19 sites were studied across the United Kingdom, spanning from northern Scotland to southwestern England. At each site, a …

Go to article

Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake Apr 2026

Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake

Senior Theses

Protein-protein interactions are important targets in cancer biology as they can make historically “undruggable” proteins viable drug targets. However, the current approach to targeting protein-protein interactions relies on the use of small molecule drugs, which have low efficiencies as they must cover a large surface area of the interaction. Further, traditional drug therapies often lead to off-target toxicity, limiting therapeutic specificity. The objective of this project is to develop a selection system in yeast to identify short peptide sequences that can disrupt protein-protein interactions specific to cancer cells. Following proof of principle and development of the AH109 yeast strain having …

Go to article

Exploring Synthesized Cbd Derivatives: Implications Of Therapeutic Strategies For Neuroinflammation, Josephine Mosser Apr 2026

Exploring Synthesized Cbd Derivatives: Implications Of Therapeutic Strategies For Neuroinflammation, Josephine Mosser

Senior Theses

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid derived from Cannabis Sativa with well-documented antioxidant and anti-inflammatory properties, yet its clinical utility is limited by moderate receptor selectivity, rapid hepatic metabolism, and broad pharmacological activity on the central nervous system (CNS). This thesis describes the design and partial execution of a multi-step synthetic route aimed at generating CBD/CBD-derived chalcone intermediates for potential therapeutic applications for neuroinflammation. The steps encompass an O-methylation, O-acetylation, and a Fries rearrangement. The first three steps were completed successfully and reproducibly shown through 1H-NMR and 12C-NMR; however, purification of the fourth step was not successful within the available …

Go to article

Antibiotics And You: A Comprehensive Guide, Brady Haas Apr 2026

Antibiotics And You: A Comprehensive Guide, Brady Haas

Senior Theses

Antibiotic resistance is a rapidly emerging issue within public health. As resistance grows, the effectiveness of traditional antibiotic therapies diminishes while risk of treatment grows. Alongside novel therapies, public knowledge is a strong combatant of the resistance-related risks of antibiotic usage. Through a comprehensive review of current literature, this work serves as an accessible guide to the mechanisms of antibiotics, bacterial resistance, and the challenges related to current antibiotic usage. Additionally, the ability of current policy and emerging novel treatments, such as nanoparticles and bacteriophage therapy, to fight antibiotic resistance is evaluated. This analysis highlights the importance of improving public …

Go to article

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin Apr 2026

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin

Senior Theses

Hypertension is the leading global risk factor for mortality and is closely associated with vascular inflammation and dysfunction. Damaged mitochondria release cell-free mitochondrial DNA (cf-mtDNA), which activates toll-like receptor 9 (TLR9). The binding of TLR9 to mtDNA activates the NLRP3 inflammasome pathway, promoting the release of pro-inflammatory cytokines via gasdermin D (GSDMD), therefore worsening inflammation. However, the mechanisms linking mitochondrial injury to inflammation-induced vascular dysfunction remain unclear. We hypothesize that cf-mtDNA triggers TLR9-dependent NLRP3 inflammasome activation contributing to vascular and endothelial dysfunction. To assess that, adult male C57BL/6 were exposed to 28 consecutive days of chronic unpredictable stress (CUS) or …

Go to article

First Prev Next Last