Digital Commons Network^™

Bax Activation Through The N-Terminal Bh3-Like Domains Of Vdac1 And Vdac2, Autumn A. Peters

Honors Theses

Voltage-dependent anion channels (VDACs) are central to mitochondrial function by mediating metabolite diffusion across the mitochondrial outer membrane (MOM). Two isoforms­­­­­­­­­­­,­­­­­­­­­­­­­­­­­­­­­­­­­­­­ VDACs 1 and 2, are also implicated in apoptosis based on interactions with Bcl-2 family proteins that control this process, including Bax and Bcl-xL. Activation of the pro-apoptotic protein Bax by interaction with ‘BH3-only’ proteins, such as Bim or Bid, induces MOM permeabilization to signal apoptosis, yet accumulating evidence indicates VDACs 1 and 2 may also affect Bax. We discovered that the VDAC N-terminal domains contain high sequence similarity to the conserved BH3 domains within Bcl-2 family members that …

A Survey Of Lichen Native To Three Of Mississippi’S National Forests, William S. Granberry Iii

Honors Theses

Lichens are a major part of the environment for telling the air quality and the impact humans have on the environment. These signs go into how many species of lichen are present in a general area, and there has been a lack of a list of lichens that call Mississippi their home. The goal of this research is to help create this list through a survey of lichen in three of Mississippi’s National Forests: DeSoto, Homochitto, and Holly Springs. These three forests are ideal because they cover differing ecosystems and are in different parts of the state, heightening the chance …

Mechanisms Underlying Diversity In Bacterial Biofilms, Jacob David Holt

Dartmouth College Ph.D Dissertations

Bacteria commonly exist in natural environments as communities of multiple strains and species attached to surfaces and encased in an extracellular matrix of DNA, protein, and polysaccharides–termed biofilms. These biofilms contribute to diverse functions, from ocean carbon cycling via chitin degradation to pathogenic processes such as wound or implant colonization. The molecular mechanisms governing biofilm formation and composition have been well characterized in model pathogenic organisms, yet the extent to which aspects of biofilm formation contribute to the assembly and maintenance of diverse communities remains less well understood. Using microfluidics, confocal microscopy, and model biofilm-forming bacteria, this thesis details how …

Windows Of Developmental Susceptibility To Tetrahydrocannabivarin (Thcv) Reveal Stage-Dependent Morphological And Biological Effects, Mirielle Clayton

Honors Theses

Tetrahydrocannabivarin (THCV), a minor cannabinoid found in Cannabis sativa, is gaining attention for its potential therapeutic applications, yet its effects on early development remain poorly understood. This study investigated how the timing of THCV exposure influences morphological, behavioral, and bioaccumulation outcomes in zebrafish (Danio rerio) embryos. Embryos were exposed to 2 μM THCV during discrete developmental windows (6–30, 30–54, 54–78, 78–102) and continuous 6–102 hours post-fertilization (hpf), designed to model early stages of human gestation. Behavioral analysis using a larval photomotor response assay revealed significant reductions in locomotor activity during dark phases, with the strongest hypoactivity observed …

Evolution Of Nematode Prey Chemotaxis Behavior Across Different Environments, Hailey R. Smith

Honors Theses

Climatic conditions in the near future are projected to be warmer, with more frequent and intense weather events. This will substantially alter the environments in which organisms must integrate specific information to find essential resources. Many organisms rely upon chemical signals to orient towards attractive resources through a mechanism called chemotaxis. How different environmental conditions, like temperature, impact this process will be important to understand as environments change. I conducted a laboratory evolution experiment with the model nematode Caenorhabditis elegans to see how success in chemotaxis assays changes over time when selected under different temperature regimes (normal laboratory temperature, increased …

The Genus Nebo Simon, 1878 (Scorpiones: Diplocentridae) In Oman, Graeme Lowe

Euscorpius

No abstract provided.

In The Garden's Grasp, Lacey Anderson

The Cicadian

This piece pairs a close-up photograph with reflective creative writing to explore a fleeting moment in a backyard garden ecosystem. Among vivid dahlias and winding vines, a grasshopper emerges, captured both in image and in story. Together, the photograph and prose invite readers to witness how tending, noticing, and lingering can transform an ordinary patio into a world alive with quiet, electric life.

Green Infrastructure As A Strategy For Revitalizing Old Residential Neighborhoods: Evaluation Of Carbon Footprint And Energy Performance - Case Study Of Heliopolis, Cairo, Ahmad Abouisaadat, Eman Gameel, Shoroq Adel

Mansoura Engineering Journal

This study aims to address the challenge of reducing energy consumption and greenhouse gas (GHG) emissions in urban areas, particularly in aging residential neighborhoods. Despite the benefits of Urban Green Infrastructure (UGI) and residential retrofitting, current research often examines these strategies separately, leaving a gap in understanding their combined impact at the district scale. The research proposes a methodology that integrates GIS-based spatial analysis, Urban Building Energy Modeling (UBEM), and Life Cycle Assessment (LCA) to evaluate the effects of UGI (e.g., green roofs, urban trees) and retrofitting strategies on energy use, CO2 reduction, and urban microclimates. The study will provide …

A Doubly Stochastic Model Of Government Interventions To Preserve Ecosystems Services In The Context Of Large-Scale Industrial Agriculture, Karma Brame, Wendy Calderon, Kaylee Clark, Josh Hiller, Natalia Negrete

Spora: A Journal of Biomathematics

Deforestation, driven by industrial agriculture and cattle farming, has significantly impacted communities and ecosystems across the globe. In this paper, we develop a discrete-time Markov model to evaluate the effectiveness of market-based interventions, such as payments for ecosystem services (PES) and taxes, in addressing forest loss within the context of large-scale agriculture. Specifically, we focus on how commodity price variability influences deforestation decisions. To model these price fluctuations, we represent agricultural prices as geometric Brownian motion (GBM). By linking commodity price dynamics to land use transitions, our model aims to provide insight into how financial mechanisms can slow or stop …

Challenges And Innovations In Tennis Coach Development: International Insights From Practitioners Across Continents, Miguel Crespo, Rafael Martinez-Gallego, Christine Nash

Journal of Coach Development

Tennis is a global sport with effective coaches being essential to the continued appeal, therefore the work of the coach developers within the International Tennis Federation (ITF) is crucial. This research examined the work and aspirations of coach developers in tennis using in-depth interviews with 10 ITF coach developers. Subsequently, we developed detailed pen portraits of two ITF coach developers at different levels of experience and engagement in order to highlight any differences in work, objectives or ambition. Findings from coach developers revealed three themes: support from ITF; barriers to learning; making learning less traditional. The pen portraits added further …

Skeletal Muscle Characteristics Long-Living Dwarf Mice In Response To High Fat Diet, Landon Schumacher, Matthew Johnston, Jaspreet Osan, Holly Brown-Borg

Arts & Sciences Undergraduate Showcase

Introduction: The effects of high fat diet (HFD; 60% kcal: fat) on skeletal muscle in mice with postnatal growth hormone deficiency is relatively unknown. We compared the tibialis anterior (TA) muscle from middle aged female Ames Dwarf and Wildtype mice fed HFD for 16 weeks and standard diet (STD; 10%: fat) to see the impacts of a HFD on inflammation and fibrotic formation in the musculature.   Methodology: Mice were euthanized after diet duration (age 10-12 months), and TAs were collected and frozen in OCT for cross-sectional cryosection. Ten um thick muscle was fixed to slides and stained with Oil Red-O …

From Sunshine To Sight Lost: Amd In North Dakota, Sidney J. Leciejewski, Diane Darland

Arts & Sciences Undergraduate Showcase

Age-related macular degeneration (AMD) is a progressive eye disease that directly harms the macula, which could eventually cause vision loss. The macula is an area on the back of the eye that contains cone cells, which allow for our color vision. Its location also allows us to have our central vision. There are two kinds: the dry and wet form, where the wet form is more extreme. The disease, itself, is highly prevalent in North Dakota, which is why it is important to note its causes and prevention methods. Some causes of AMD include genetic risks,  health risks, and metabolic …

The Ccu Disease Hunters: Putting Undergraduate Research To Work To Improve Community Health And Training The Next Generation Of Doctors, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Reptiles Of The Northeastern Piedmont Of South Carolina, Steven E. Fields

Journal of the South Carolina Academy of Science

No abstract provided.

Clethra Alnifolia: A Fact Sheet For Seed Transfer Considerations, Taylor Houggy

Plant Science Articles

Clethra alnifolia is a highly prized fragrant deciduous shrub, often found in many home gardens across Eastern North America. Despite its popularity in the landscape industry, there is little research comparing C. alnifolia's natural habits in the wild to its habits as a landscaped cultivar. Information such as flowering phenology, genetic diversity, and growth habits have the potential to change considerably depending on C. alnifolia's location. Because of this, it is important that landscape growers as well as forest conservationists have access to ecological fact sheets in order to make informed decisions when transferring seed to different areas. In this …

Great Graminoids! Quantifying Vegetation On Roan’S Western Balds Over The Last 80 Years (1936, 1956, 2016), James T. Donaldson

Faculty Open Access Works

PowerPoint originally presented at Friends of Roan Mountain Winter Naturalists' Rally 11 Feb. 2017.

Grant funding from Friends of Roan Mountain for resampling historic transects from Carvers Gap to Grassy Ridge. Revised 2021, 2022, & 2023 (technical features and diversity); edited for clarity 2026 (for written rather than oral presentation & added references slide).

From Stranger To Self: The Role Of Familiarity In Modulating The N170 And N250 Erp Components, Tabish Gul

Dissertations

This study investigated how varying levels of face familiarity modulate the N170 and N250 event-related potential (ERP) components, two neural markers of face perception and recognition. While the N250 is widely considered familiarity-sensitive, the N170 has traditionally been linked to the structural encoding stage of face perception. However, recent research suggests that face familiarity may also influence N170 amplitude and latency. While most previous studies have compared up to three familiarity levels, the present study examined five levels of familiarity: own face, friend’s face, famous face, experimentally familiar face, and unfamiliar face. Twenty-six participants viewed face images while completing a …

Brachial Macroparasite Loads In Estuarine Young-Of-Year Striped Mullet (Mugil Cephalus), Triston Rice

Honors Theses

Climate change is a growing threat to marine habitats globally. One ecological impact that warming water temperatures poses is the increased metabolic rate of many parasite species. Their promoted reproductive and feeding rates could pose a threat to the stability of many host populations. Parasites of the gills, or brachial parasites, are especially concerning to fish populations globally. As parasitism is not limited to a specific taxon and comprises a large diversity of ecomorphs and behaviors, geographically distinct areas may be differentially affected by the changing prevalence of parasites. This study aimed to survey current brachial parasite abundance and prevalence …

Oregon State Rank Assessment For Bedstraw Broomrape (Aphyllon Epigalium Ssp. Epigalium), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Bedstraw broomrape (Aphyllon epigalium ssp. epigalium) using NatureServe methodology, 2026.

Neuroprotective Effects Of Estradiol And Genistein And Interactions With Aromatase Inhibitions Post Cerebellar Lesion In Male Zebra Finches, Grace E. Thompson, Anthony P. Irovic

Honors Theses

Across vertebrates, peripheral and brain-derived estradiol (E₂) promotes neuroplasticity. After injury, E₂ can be derived locally from testosterone via aromatase (AROM), an enzyme that is upregulated in glia at the site of neural injury. E₂disrupts testicular function and elevates cancer and stroke risk, primarily via binding to estrogen receptor alpha (ER α). Genistein (GEN), a phytoestrogen, is similar to E₂ but binds preferentially to estrogen receptor beta (ER β). It may offer neuroprotection without adverse effects of E₂. We used adult male zebra finches (ZF) to model neuroprotective effects of E_{2 …}

Ectomycorrhizal Fungal Identity Strongly Influences Soil Properties Relative To Pine Presence And Soil History In A Pine–Eucalyptus System, Braedan Watters

Honors Theses

Invasive Pinus radiata has increasingly spread into native ecosystems in the Southern Hemisphere, including Eucalyptus forests in Australia, where it forms novel hybrid forest systems in which invasive and native tree species coexist. The success of these invasions is closely tied to ectomycorrhizal fungi (EMF) such as Rhizopogon spp., yet the relative roles of pines versus their fungal symbionts in altering soil properties remain poorly understood. This study investigated the independent and interactive effects of soil history (Pinus or Eucalyptus), EMF identity, and pine presence on soil properties using a controlled factorial experiment. Soil from beneath either Pinus …

Beyond The Bug: How The Covid-19 Pandemic Exposed Longstanding Systemic Failures In The United States Workforce And Economy, Abbey M. Markley

Honors Theses

The purpose of this thesis is to investigate and discuss how longstanding systemic failures in the United States exacerbated the effects the COVID-19 pandemic had on the American economy, essential healthcare workers, and overall public trust in institutions. A review of the existing literature surrounding this topic and the subsequent results of various studies were used to compose this thesis. The United States has a painful lack of worker protections and tends to view members of its workforce as expendable, even in times such as pandemic when they are deemed essential. Healthcare workers in particular faced increasing threats to their …

Biochemical Characterization Of Luciferase In Omphalotus Olearius, James H. Martin

Honors Theses

The overall goal of this thesis was to investigate the genetic basis of bioluminescence in Omphalotus olearius, a bioluminescent mushroom. The project initially focused on growing fungal cultures under controlled laboratory conditions and using molecular techniques such as DNA extraction, PCR, and gel electrophoresis to identify the organism and isolate the gene responsible for light production. The main objective was to insert this gene into a bacterial system to confirm its function through observable bioluminescence. However, repeated difficulties in maintaining viable fungal cultures and errors in molecular procedures resulted in inconclusive results, preventing successful gene identification. Due to these …

Antibiotic Resistance Patterns In Bacterial Isolates From Mississippi Gulf Coastal Environments, Lawler F. Horn

Honors Theses

Coastal environments host diverse microbial communities that play essential ecological roles but may also serve as reservoirs for antibiotic-resistant bacteria. This study investigated patterns of antibiotic resistance in microbial isolates collected from public beaches along the Mississippi Gulf Coast. A total of 143 bacterial isolates exhibited growth and were included in antibiotic susceptibility screening. High levels of antibiotic resistance were observed, with 137 of 143 isolates showing growth on vancomycin, 124 on amoxicillin, and 102 on erythromycin. Resistance to kanamycin (19/143 isolates) and tetracycline (33/143) was less common. Multidrug resistance was widespread, with 101 isolates (70.6%) resistant to three or …

Functionalized Nanodiamonds As Binding Platforms For Single-Stranded Dna, Mallory A. Chapman

Honors Theses

Nanodiamonds (NDs) offer a promising platform for biomolecular applications due to their stability, biocompatibility, and three-dimensional structure. This study focused on developing a nanodiamond–DNA complex in which streptavidin-functionalized NDs would form a protective shell around biotinylated single-stranded DNA (ssDNA), creating a core–shell system like an “M&M” candy with DNA at the center and a protective coating on the outside. DNA has many uses in nanotechnology, including DNA origami, nanomachines, and drug delivery systems, but its degradation limits its practical use, making protective strategies essential.

ND–DNA conjugates were prepared using biotin–streptavidin interactions and analyzed using gel electrophoresis. Initial separation on agarose …

Community Composition Of Antibiotic-Resistant Bacteria On The Mississippi Gulf Coast, Marisa Martin, Colin Jackson

Honors Theses

The Mississippi Gulf Coast is an important resource for transportation, economic development, and recreation. Given its economic and cultural importance, it is crucial to maintain clean and safe conditions along the coast for public health, but other than routine beach monitoring, few studies have examined microbial contamination of coastal waters in this region. This study aimed to determine the quantity, composition, and distribution of bacteria resistant to six different antibiotics (Vancomycin, Kanamycin, Tetracycline, Ciprofloxacin, Erythromycin, or Amoxicillin) in seawater at seven public beaches along the Mississippi Gulf Coast. No bacteria resistant to Ciprofloxacin were detected, and bacteria resistant to Kanamycin …

Life History, Stock Status, And Movement Ecology Of Narrow-Barred Spanish Mackerel, Scomberomorus Commerson (Lacépède, 1800) In The Southern Arabian Gulf, Mohamed Abdulla Almusallami

Thesis/ Dissertation Defenses

The narrow-barred Spanish mackerel, Scomberomorus commerson, is the most commercially valuable pelagic fish species in the Arabian Gulf. This thesis integrated three studies to comprehensively assess the life history, stock status, and movement ecology of this species in Abu Dhabi waters. Life history traits were characterized from data collected during a 15-month monitoring program (January 2019–May 2020). Fork length ranged from 30.5 to 132 cm. Growth parameters were k = 0.14–0.15 year⁻¹ and L∞ = 128.9–135.4 cm for males and females, respectively. Size-at-maturity (Lm₅₀) was 78.7 cm FL for females and 69.7 cm FL for males. The spawning season occurred …

Invasive Macrofungi In The United States: A Mushrooming Crisis, Emily Torres

Student Theses 2015-Present

Globalization has accelerated the spread of invasive species, making them one of the largest contributors to biodiversity loss worldwide. While invasive macrofungi remain largely absent from scientific discourse on invasive species, they represent a growing ecological concern throughout the United States. Invasive macrofungi disrupt forest ecosystems, alter soil communities, and displace native fungi. Beyond these ecological impacts, their presence and establishment profoundly affect human-nature relationships, most notably mushroom foraging and cultivation practices. This paper adopts a multidisciplinary approach to examine the ecological, economic, and anthropogenic impacts of invasive macrofungi in the United States. Chapter 1 provides a quantitative overview of …

Atomoxetine Enhances Specific Dimensions Of Cognitive Performance In A Rodent Strategy Shifting Assay, Jessica Ivanov

Rowan-Virtua Research Day

Title: Atomoxetine enhances specific dimensions of cognitive performance in a rodent strategy shifting assay

Authors: Jessica Ivanov, Christopher P. Knapp, Barry D. Waterhouse, Rachel L. Navarra

Objective: Cognitive flexibility, a domain of executive function, supports adaptive shifts in behavior in response to changing environmental demands and task contingencies. Deficits in this capacity are common to neuropsychiatric disorders such as Attention Deficit Hyperactivity Disorder (ADHD), where improper regulation of the catecholamine transmitters dopamine (DA) and norepinephrine (NE) within the prefrontal cortex (PFC) has been implicated. Atomoxetine (ATX), a selective NE transporter (NET) inhibitor, elevates levels of NE and DA in the …