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The Effects Of Preventing Dephosphorylation Of Lqg1 On Cytokinesis, Jenna Mueller

Miners Solving for Tomorrow Research Conference

Iqg1 plays crucial roles in cytokinesis, including the assembly, contraction, and disassembly of the actomyosin ring, as well as the coordination of contraction and septation. Given that cytokinesis must occur post-mitosis, Iqg1 is regulated by the cell cycle. This study explores hypotheses regarding Iqg1 regulation: it’s binding to action is negatively influenced by the cyclin-dependent kinase (CDK) Cdc28 and positively influenced by dephosphorylation via Cdc14. Newly developed yeast degron tagged strains allow for rapid depletion of specific proteins. Iqg1 mutations that alter serine to threonine, which allows phosphorylation but not dephosphorylation, in the degron strain allow testing of mutant phenotypes. …

The Stability Study Of Dna-Polymer Hybrids For Nanotechnology Applications, Ethan Kuehn, Milan Jebaraj

Miners Solving for Tomorrow Research Conference

DNA nanostructures have garnered increasing interest in their application as drug delivery vehicles. However, DNA is susceptible to degradation under physiological conditions. To remedy this, we have devised a novel method to coat DNA nanostructures with the polysaccharide chitosan (a natural derivative of chitin). Chitosan binds to DNA electrostatically and inhibits nuclease activity that would normally degrade DNA in a physiological environment. We used both agarose gel electrophoresis (AGE) and atomic force microscopy (AFM) to determine the stability of DNA before and after immersion in a simulated biological environment. Physiological conditions were mimicked by incubating the DNA in cell culture …

Biosensors For Biomedicine, Drake O'Leary

Miners Solving for Tomorrow Research Conference

This project investigated the use of engineered bacterial reporter systems to detect cellular stress responses associated with antibiotic activity. While constructs were successfully introduced and tested against known antibiotics, the reporter consistently produced a blue signal across conditions, limiting the ability to distinguish specific stress responses. This suggests issues such as leaky expression, insufficient regulatory control, or lack of specificity in the reporter design. Although results were inconclusive, this work highlights key challenges in developing reliable biosensors and provides a foundation for future optimization. Improving signal specificity and reducing background expression will be critical for enabling accurate characterization of antibiotic …

Asphalt Pavement Rejuvenation Investigated By Nuclear Magnetic Resonance Relaxometry, Catherine Skaggs

Miners Solving for Tomorrow Research Conference

Asphalt is a relatively inexpensive material commonly used for road pavements; however, asphalt ages from exposure to oxygen and UV radiation, leading to loss of elasticity, which leads to cracks and potholes. To slow or reverse asphalt aging, pavement preservation treatments are in use. It’s unclear whether these treatments truly rejuvenate the pavement structure or merely offer a short-term benefit. Nuclear Magnetic Resonance (NMR) relaxometry is an analytical technique that uses the recovery of excited nuclear magnetization as a parameter to gain insights into molecular environments. Recovery-time distributions gathered from asphalt materials show differences between regular and rejuvenated asphalt samples, …

Antibiotics And You: A Comprehensive Guide, Brady Haas

Senior Theses

Antibiotic resistance is a rapidly emerging issue within public health. As resistance grows, the effectiveness of traditional antibiotic therapies diminishes while risk of treatment grows. Alongside novel therapies, public knowledge is a strong combatant of the resistance-related risks of antibiotic usage. Through a comprehensive review of current literature, this work serves as an accessible guide to the mechanisms of antibiotics, bacterial resistance, and the challenges related to current antibiotic usage. Additionally, the ability of current policy and emerging novel treatments, such as nanoparticles and bacteriophage therapy, to fight antibiotic resistance is evaluated. This analysis highlights the importance of improving public …

Heterogeneity Of Treatment Effects In Transcranial Direct Current Stimulation For Knee Osteoarthritis Pain And Symptoms, Chiyoung Lee, Xiaoxiao Sun, Juyoung Park, Chen X. Chen, Christine Pellegrini Ph.D., Nan-Kuei Chen, David O. Garcia, Heewon Kim, C. Kent Kwoh, Hyochol Ahn

Faculty Publications

Introduction: Although heterogeneity of treatment effects (HTEs) is commonly observed in clinical trials, it has received little attention in studies on transcranial direct current stimulation (tDCS).

Objectives: This study identified the presence of HTE in tDCS treatment among participants with symptomatic knee osteoarthritis (KOA) and explored participant characteristics associated with this heterogeneity.

Methods: This secondary analysis of a randomized clinical trial included 120 participants with symptomatic KOA who received 15 daily sessions of home-based 2-mA active or sham tDCS over 3 weeks. We used a multitrajectory analysis to identify distinct subgroups based on the longitudinal trajectories of KOA pain and …

Heterogeneity Of Treatment Effects In Transcranial Direct Current Stimulation For Knee Osteoarthritis Pain And Symptoms, Chiyoung Lee, Xiaoxiao Sun, Juyoung Park, Chen X. Chen, Christine Pellegrini, Nan-Kuei Chen, David O. Garcia, Haewon Kim, C. Kent Kwoh, Hyochoi Ahn

Faculty Publications

Introduction: Although heterogeneity of treatment effects (HTEs) is commonly observed in clinical trials, it has received little attention in studies on transcranial direct current stimulation (tDCS).

Objectives: This study identified the presence of HTE in tDCS treatment among participants with symptomatic knee osteoarthritis (KOA) and explored participant characteristics associated with this heterogeneity.

Methods: This secondary analysis of a randomized clinical trial included 120 participants with symptomatic KOA who received 15 daily sessions of home-based 2-mA active or sham tDCS over 3 weeks. We used a multitrajectory analysis to identify distinct subgroups based on the longitudinal trajectories of KOA pain and …

Cellular And Molecular Characterization Of Ube3a Function In Cic-Dux4 Sarcoma, Jesse D. Walker

Theses

CIC-DUX4 sarcoma (CDS) is a rare and extremely aggressive soft tissue sarcoma that primarily affects children and young adults. CDS is characterized by an oncogenic chromosomal translocation. Current treatments for CDS are similar to those in other sarcomas like surgery, chemotherapy, and radiation. Treatments, however show that CDS responds poorly compared to other sarcomas, due to relapses of localized disease at high rates and short duration response of treatment, proving the importance of understanding CIC-DUX4’s complex role on how it regulates overall gene expression in CDS cells from a molecular approach.

UBE3A is a ubiquitin protein ligase that plays a …

Burnout Sentinel: An Early Warning System For Student Burnout Using Workload And Recovery Indicators, Minh Duy Do

Expo Student Presentations

2026 Spring Expo Video Essay Presentation

• Biological & Life Sciences
• Health Sciences & Health Professions
• Physical & Applied Sciences
• Service-Learning
• Social & Behavioral Sciences

Remove To Recruit: The Short-Term Efficacy Of Invasive Shrub Removal In A Minnesota Floodplain Forest, Claire S. Wiley

Biology Honors Projects

Within Midwest floodplain forests, there is a lack of long-term studies focusing on native tree recruitment post invasive shrub removal. With interacting threats such as emerald ash borer (Agrilus planipennis), invasive earthworms, and white-tailed deer (Odocoileus virginianus), land managers need particular information about these ecosystems in order to better understand how to protect them. This study aims to explore the efficacy of the removal of Rhamnus cathartica and Lonicera spp. in promoting native tree recruitment within a Minnesota floodplain forest along the Mississippi River. Results revealed that post removal ash (Fraxinus spp.) seedling abundance …

Research Day 2026 Program, Western Michigan University Homer Stryker M.D. School Of Medicine

Research Day

No abstract provided.

Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges, Rosemary Westphal, Ms

Student Papers, Posters & Projects

Glioblastoma multiforme is the most common adult primary tumor with a grim median survival time of 14.6 months. It is characterized by rapid progression, diffuse infiltration, and rather poor clinical outcomes. The WHO classifies GBM as a grade 4 diffuse astrocytic tumor with distinctive histopathological features including high mitotic activity, marked cellular atypia, microvascular proliferation, and necrosis. Advances in molecular diagnostics have further classified GMB into IDH-wild type and IDH-mutant subtypes, with important therapeutic and prognostic implications. Key genetic alterations, such as EGFR amplification, PTEN loss, TP53 mutations, TERT promoter mutations, and MGMT methylations, have been identified as contributing to …

Ecovoltaic Solar Energy Development Creates Novel Microclimate, Temperature, And Soil Moisture Patterns Under Solar Panels In A Warm Desert, Juan Pinos, Seth M. Munson, Claire C. Karban, Matthew D. Petrie

Life Sciences Faculty Research

Background As solar energy development expands in desert regions, new installation practices and solar technologies seek to balance ecosystem conservation and energy generation (ecovoltaics). The Gemini Solar Project, a large ecovoltaic facility located in the northeastern Mojave Desert, employed low impact installation methods to reduce disturbance of the desert ecosystem within arrays of bifacial panels mounted on solar tracking systems. We evaluated microclimate and environmental conditions across five locations: four within-facility microsites (underneath solar panels, east and west panel driplines, and interspaces between panel rows) and one in the undisturbed desert outside the facility. Results Under panel microsites experienced lower …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Quantifying The Antifungal Properties Of Bacteria Using Cotton Strips, Lily Lofton

Honors Theses

Many bacteria have been known to have antifungal properties. Research has begun to determine how these bacteria can be used to protect cotton and other cellulose-rich textiles. In the present study, standardized cotton strips were inoculated with two different bacterial consortia that have exhibited anti-fungal properties. These strips were then inoculated with the melanized cellulolytic fungi, Chaetomium globosum and Rhinocladiella similis. Similarly, some cotton strips were also inoculated with a non-melanized fungus, Rhodotorula toruloides, which is also thought to be cellulolytic. The tensile strength of cotton strips was measured along with the ergosterol concentrations (fungal biomass) for each cotton strip …

Developing A Range Prediction For The Imperiled Florida Harvester Ant (Pogonomyrmex Badius) Using Species Distribution Modeling, Noah Williamson

Honors Theses

The Florida Harvester Ant (Pogonomyrmex badius) was once widespread and commonplace throughout the sandhills of the Southeastern United States, providing key ecosystem services, such as seed dispersal and soil aeration. Over recent decades, however, Florida Harvester Ant populations have declined in some areas. Current literature postulates that Red Imported Fire Ants (RIFA), and the insecticides used to manage them, as well as further human encroachment onto their habitat, all likely contributed to Florida Harvester Ant population declines. Thus, to better protect these organisms, pursue data-driven conservation efforts, and guide management practices, more information about their nest site selection, as well …

Increased Backbone Rigidity Of Artificial Transcription Factors, Jasmine Glover, Emma Otey, Joanna K. Kwao, Nicholas Truex

Senior Theses

Programming DNA-binding proteins is an effective strategy for developing therapeutics that regulate gene expression. These proteins can directly bind to DNA to activate or repress transcription of specific genes. Zinc finger proteins are a class of DNA-binding proteins commonly found in eukaryotic organisms. Their DNA-binding function is derived from unique amino acid sequences within each domain that recognizes specific nucleotides, allowing each finger to selectively recognize three DNA base pairs. Adjoining of multiple domains in tandem allows recognition of a specific DNA sequence. Artificial transcription factors can be made of multiple zinc finger domains arranged in tandem and engineered to …

Testing The Intermediate Disturbance Hypothesis On Anthropogenic Pressure In Central Alabama, Gavin Terrell

Theses

Biodiversity is fundamental to maintaining ecosystem structure and function globally. Prior to the late 20th century, ecological theory generally predicted that biodiversity would be highest in systems experiencing minimal disturbance. However, Joseph H. Connell challenged this view with the Intermediate Disturbance Hypothesis (IDH), which posits that species diversity peaks at intermediate levels of disturbance and declines under conditions of both low and high disturbance. Although widely cited, the applicability of the IDH to natural systems remains debated, particularly in the context of anthropogenic disturbances and when diversity is measured beyond species richness alone.

This study evaluated the predictions of the …

Agronomic Practices For Climate-Resilient Okra Production In Agroecological Systems: A Review, Samuel Mathu Ndungu, Lokeshwar Kesamreddy, Mathieu A.T. Ayenan, Stephen Othim, Siyabusa Mkuhlani, Yu Hsiang Liu, Amha Besufkad, Wubetu Bihon Legesse, Eric C. Legba, Judith Honfoga, Lukas Pawera

All Peer-Reviewed Publications

Okra is increasingly recognized as a climate-resilient crop within diversified agroecological systems; however, an integrated synthesis of its biophysical, agronomic, and socioeconomic dimensions is lacking. This review consolidates the current knowledge on okra physiology, production ecology, and value chains, with a focus on climate resilience under heat, drought, salinity, pest, and disease pressures. Evidence across regions demonstrates that agroecological practices such as crop diversification, mulching, conservation tillage, integrated pest management, and the use of organic and biological inputs consistently improve soil health, stabilize yields under climatic stress, and reduce dependence on external inputs, although with trade-offs in labor demand and …

Music Listening While Studying And Academic Performance Among College Students With Attention Deficit And Hyperactivity Disorder, Raihan K. Khan, Md Towfiqul Alam, Madalynn Nofplot, Sojib Bin Zaman, Catherine L. Zaman

Faculty Scholarship

Evidence on whether music listening supports academic performance, particularly among students with attention deficit and hyperactivity disorder (ADHD), remains mixed. We explored associations between music listening while studying and academic performance (GPA: grade point average) among college students, and to evaluate whether the associations differed by ADHD status. We analyzed cross-sectional survey data from college students and conducted linear regression models with self-reported GPA as the dependent variable. Models were adjusted for sex, academic level, college affiliation, primary study location, weekly study hours, and preferred genre of music. A total of 541 students participated. Most of the students were at …

An Insight Into The Venom Gland Proteome Of The Two-Spined Trap-Jaw Ant, Odontomachus Haematodus, Aaron Morgan

Honors Theses

Ants are ecologically important and highly abundant organisms, playing key roles in many ecosystems. One recently introduced species in the southeastern United States is Odontomachus haematodus (the two-spined trap-jaw ant), a South American native that has often been misidentified, contributing to limited research on its biology and venom composition. This study aimed to provide the first detailed characterization of the venom apparatus and proteome of O. haematodus. Specimens were collected and dissected, and venom-related proteins were extracted and analyzed using SDS-PAGE and tandem mass spectrometry (MS/MS-ESI). Confocal microscopy was also used to visualize the sting apparatus, including F-actin filaments and …

Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Wednesday, April 1, 2026, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on April 1, 2026.

Evolution As Spatial Projection, Charles H. Smith, Ngoc Nguyen

Faculty/Staff Personal Papers

A theory combining explanations for the nature of three-dimensional systems and evolutionary processes is advanced, set to a geometric simulation, and then discussed in the context of several empirical studies bearing on its validity. The concept “evolution” is first discussed, then related to Baruch de Spinoza’s ideas on natural philosophy, including his concept of the conatus. These ideas are then extended by posing the possible existence of a general form of natural systems subsystemization leading to the extended space condition. A geometrical/topological simulation study projecting spatial relations among subsystem structures interpretable through entropy maximization and multidimensional scaling methods is presented, …

Ellie - Exteroceptive Light Locomotion In Eukaryote-Fungi, Brandon Etwarroo

Doctoral Dissertations and Master's Theses

Over the past decade, fungal research and its technological applications have expanded across multiple disciplines, including the emerging field of biohybrid systems. This thesis develops and evaluates a wireless, untethered mobile robot controlled by the action potential-like activity generated by Pleurotus ostreatus sporocarps under red, green, and blue optical stimulation. Light is applied to the sporocarps, the resulting electrical responses are recorded, and these signals are transmitted wirelessly to actuate the mobile robot. Both the action potential-like activity patterns and the robot’s movement trajectories were analyzed. The results demonstrate that wireless robotic control mediated by fungal electrophysiology is feasible. Overall, …

First High-Quality Genome Assembly Of Umbelopsis Nana Isolated From Forest Soil, Ryuka Iizuka, Tomohiro Suzuki, Nozomu Watanabe, Javier F. Tabima, David Hibbett, Yoko Katayama, Makoto Yoshida

Biology

Species of the genus Umbelopsis are ubiquitous soil saprotrophic fungi known for their role in ecological nutrient cycling and biotechnological potential in lipid production. Here, we present the genome assembly of Umbelopsis sp. strain THIF13, which is characterized by its capability to produce carbonyl sulfide. Using PacBio Sequel long-read data, a high-quality genome assembly was generated comprising 18 contigs totaling 27.2 Mb, which is larger than other Umbelopsis genomes, with an N50 of 1.77 Mb. Notably, 16 contigs were flanked by telomeric repeats at both ends. The assembly showed high completeness, with 98.1% complete Benchmarking Universal Single-Copy Orthologs and 11.15% …

Abundance Of Microplastics In The Water And Stream Fish Of Big Walnut Creek, David J. Hartman

Undergraduate Honors Thesis Projects

Microplastics are a major threat to both ecosystem and human health. In this study, I investigated the abundance of microplastics at five sites along Big Walnut Creek, Ohio including sites upstream, downstream, and within urban development. Samples were taken from the stream surface water and fish at each site. Microplastics were detected in the surface water and fish at all five sites with a total of 383 microplastic particles found in the 157 fish collected for this study. The mean concentration for all sites was 80.8 particles/m3 in the surface water and 2.4 particles per fish. Microplastics were almost entirely …

"I Need Help!": Can Ashwagandha Reduce Inflammation-Driven Oxidative Stress Without Inducing Cytotoxicity In Macrophages?, Caitlyn Pinaga

Posters - 2026

Ashwagandha has been shown to reduce inflammation in humans by lowering pro-inflammatory cytokines and oxidative stress markers, helping regulate immune responses. It is commonly used to support conditions linked to chronic inflammation, such as stress-related disorders, arthritis, and metabolic imbalance. THP-1 macrophages are a part of the body's immune response to inflammation. While they produce a lot of different responses to inflammation, one of them is the production of Reactive Oxygen Species (ROS). N-acetylcysteine (NAC) is established to be a powerful antioxidant and is used as a positive control. My study aims to understand how ashwagandha, a popular supplement, affects …

Detecting Cancer Genes Using Graph Neural Networks, Marvin Masabo Nkaka

Posters - 2026

• Cancer survival prediction is challenging due to the complexity of genomic data and limited samples especially for rarer cancer types. • To address this challenge, we developed an Artificial Neural Network (ANN) model for survival analysis using RNA-sequencing gene expression data from The Cancer Genome Atlas (TCGA). • Moreover, a key concept we investigate was how transfer learning enhanced our model’s performance especially for rarer cancer types difficult to perform accurate survival analysis due to their limited samples.

Evaluation Of Prosthetic And Orthotic Technologies Using Ai Technology, Iris Reyna, Samerial Brown, Gary Guerra, Ed Khu

Posters - 2026

Individuals with lower limb prosthetics have amputations and abnormal limb motions, which poses a high risk of injury when doing everyday activities. In this field, evaluation of individuals' prosthetics are done through biomechanical analysis and gait analysis. This analysis is used to study human movement and evaluate the mobility and quality of life of amputee patients as well as determining the modifications, positioning, and alignment needed to ensure stability with prosthetic and orthotic technologies (Kumar & Bhowmik, 2024). Trunk flexion has importance to the study because of its impact on lower limb kinetics, kinematics, the increase of ground reaction forces, …

Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang

Chemistry Faculty Research & Creative Works

Cataract is a leading cause of vision impairment worldwide and are primarily caused by oxidative stress that damages and aggregates lens proteins, leading to lens opacification. However, the eye's anatomical barriers limit the penetration and bioavailability of antioxidant therapies. To address this challenge, a dendrimer-based nanogel with a built-in reactive oxygen species (ROS)-scavenging capability developed by us was employed to deliver the antioxidant N-acetylcysteine (NAC) to the lens. NAC was loaded into a generation-5 PEGylated poly(amidoamine) dendrimer (G5-PEG-TK, termed the GPT) nanogel. The resulting NAC-GPT was characterized for its ROS-scavenging activity, bioavailability, and corneal permeability. The efficacy of NAC-GPT was …