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The Role Of The Microbiome In Gynecological Cancers: Implications For Diagnosis And Treatment, Precious Adeoye Oyedokun, Bobola Timothy Oyeleke, Onigbinde Oluwanisola Akanji, Abraham Ololade Oyelaran, Kehinde Philip O, Grace Bosede Akanbi, Philip Olagbede Oyedokun, Marvelous Dasola Oyedokun, Chikezie Chinelo Naomi, Oyeniran Oluwatosin Imoleayo, Roland Eghoghosoa Akhigbe Apr 2026

The Role Of The Microbiome In Gynecological Cancers: Implications For Diagnosis And Treatment, Precious Adeoye Oyedokun, Bobola Timothy Oyeleke, Onigbinde Oluwanisola Akanji, Abraham Ololade Oyelaran, Kehinde Philip O, Grace Bosede Akanbi, Philip Olagbede Oyedokun, Marvelous Dasola Oyedokun, Chikezie Chinelo Naomi, Oyeniran Oluwatosin Imoleayo, Roland Eghoghosoa Akhigbe

Michigan Tech Publications

Gynecological malignancies such as cancer of the cervix, ovary, endometrium, vulva, and vagina pose a severe global health burden. Although conventionally attributed to genetic mutation, hormonal imbalance, and chronic viral infection, including high-risk human papillomavirus, recent evidence suggests that the human microbiome plays a central role in their pathogenesis and development. This review summarizes existing evidence that microbial dysbiosis, specifically the depletion of beneficial Lactobacillus species and overrepresentation of anaerobic organisms such as Fusobacterium, Atopobium, and Sneathia, is implicated in carcinogenesis pathways. These include chronic inflammation, immune modulation, loss of epithelial barrier integrity, microbial metabolite toxicity, and estrogen metabolism by …


Scientific Research In Cuba: A General Analysis With A Special Focus On Energy, Agriculture And Technology, Henri Dou, Pierre Fournie Apr 2026

Scientific Research In Cuba: A General Analysis With A Special Focus On Energy, Agriculture And Technology, Henri Dou, Pierre Fournie

International Journal of Islands Research

An analysis of science in Cuba is carried out using data from the OpenAlex database. Examples are developed: agriculture, rice, technology in relation to the current situation: national food supply, energy and medicine. The predominance of research in biology and medicine and the low commitment in the fields of agriculture, energy, medicinal plants and technology are highlighted. Various development schemes are proposed. The conclusion is that research must be directed towards strategic areas: food and energy, must be less dispersed and that technology must be better taken into account. Three proposals are made: the development of a chemical analysis platform …


​Spectrophotometric Detection Of Food Additives And Pesticides By Magnetite Cross-Linked Tyrosinase Aggregates (Mcltas)​, İlker Polatoğlu Apr 2026

​Spectrophotometric Detection Of Food Additives And Pesticides By Magnetite Cross-Linked Tyrosinase Aggregates (Mcltas)​, İlker Polatoğlu

Turkish Journal of Agriculture and Forestry

In this study, tyrosinase enzyme was cross-linked with glutaraldehyde to form aggregates on the surface of activated magnetite nanoparticles, without the need for a separate support matrix. For the first time, this novel aggregate was employed for the spectroscopic detection of ascorbic acid (AA) and diazinon, as model food additives and pesticides, respectively. This technique, developed as an alternative to optical sensors, not only eliminates their drawbacks but also facilitates the recovery of cross-linked enzyme aggregates (CLEA) from the reaction medium using the incorporated magnetite nanoparticles. A spectrophotometric technique was used to measure the enzyme activity of the aggregates to …


Effect Of Some Organic Fertilizers On Yield And Quality Of Olive Oil In Semiarid Conditions, İshak Bayyi̇ği̇t, Ebru Sakar Apr 2026

Effect Of Some Organic Fertilizers On Yield And Quality Of Olive Oil In Semiarid Conditions, İshak Bayyi̇ği̇t, Ebru Sakar

Turkish Journal of Agriculture and Forestry

This two-year field experiment evaluated the effects of different organic fertilizers on olive oil quality of the Gemlik cultivar grown under semiarid conditions in Mardin, Türkiye. Treatments of olive pomace (P1: 4, P2: 8, P3: 12 kg tree⁻¹), leonardite (L1: 1.5, L2: 3.0, L3: 4.5 kg tree⁻¹), and vermicompost (SG1: 3, SG2: 6, SG3: 9 kg tree⁻¹) were applied in a randomized complete block design with three replicates. Oils were analyzed for free acidity (FA), peroxide value, and phenolic profile using high-pressure liquid chromatography. FA ranged from 0.27% to 0.42% (as oleic acid), remaining well below the International Olive Council …


Biomechanical Effects Of Bilateral Torsion And Skeletal Fusion: A Case Study, Linnéa Forbes Apr 2026

Biomechanical Effects Of Bilateral Torsion And Skeletal Fusion: A Case Study, Linnéa Forbes

Honors Projects

As part of both a personal endeavor and an academic project, I have investigated the aetiology and treatment of seemingly idiopathic and debilitating leg pain in a patient over the past 10 years. Via collaboration with medical professionals at Cincinnati Children’s Hospital, Cincinnati Premier Physical Therapy, and Cincinnati Women’s TriHealth, I have identified sources of pain at the anatomical level. The combination of internal femoral torsion, external tibial torsion, pes planus, and bony fusions appear to be major perpetuators of the pain. An effective treatment continues to be evasive. To date, I have attempted to find answers through genetic approaches, …


Investigating The Cost And Efficiency Of Two Chemical Pathways To Produce The Plant-Based Coagulants, Taylor Nixon Apr 2026

Investigating The Cost And Efficiency Of Two Chemical Pathways To Produce The Plant-Based Coagulants, Taylor Nixon

Honors Theses

Plant-based coagulants are promising sustainable alternatives for water treatment due to their biodegradability, low toxicity, and reduced risk of secondary pollution. Unlike conventional inorganic coagulants, they generate less sludge and avoid secondary contamination in the environment. This project examines two chemical modification strategies for producing cationic cellulose coagulants. The first involves direct amination of cellulose using CHPTAC, while the second employs periodate-oxidized dialdehyde cellulose, which enables reductive amination through reactive aldehyde groups. These approaches are expected to yield materials with differing charges, surface functionalities, and structural properties that may influence coagulation performance. The study evaluates the technical and economic feasibility …


Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r Apr 2026

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …


On The Transport Of Chloroplast Lipids, Cailin Smith Apr 2026

On The Transport Of Chloroplast Lipids, Cailin Smith

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Chloroplasts are green, photosynthetically active organelles ubiquitous to the plant kingdom. Owing to their cyanobacterial origin, chloroplasts consist of three membranes: the outer envelope, the inner envelope, and the thylakoid, the latter of which is the site of the light-dependent reactions of photosynthesis. Not only do the lipids that make up these membranes delineate aqueous compartments, but they also respond dynamically to developmental and environmental cues, constitute the matrix that scaffolds protein machinery, and even serve as functional components of some proteinaceous complexes. However, while lipids are of vital importance to the structure and function of the chloroplast, the mechanisms …


Quantifying Sleep Wake Rhythms In The Hospital Environment With Digital Technologies, Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks, Antonijo Mrčela, Nicholas F. Lahens, Makayla Cordoza, Sean Sarles, Amarachi Mbadugha, Dineth R. Karunamuni, Shikhar Gupta, Charles J. Bae, Amita Sehgal, Thomas P. Cappola, Jacob T. Gutsche, Pavan Atluri, Nimesh D. Desai, Michael A. Acker, Gregory R. Grant, Richard J. Schwab, Ilene M. Rosen, Garret A. Fitzgerald Apr 2026

Quantifying Sleep Wake Rhythms In The Hospital Environment With Digital Technologies, Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks, Antonijo Mrčela, Nicholas F. Lahens, Makayla Cordoza, Sean Sarles, Amarachi Mbadugha, Dineth R. Karunamuni, Shikhar Gupta, Charles J. Bae, Amita Sehgal, Thomas P. Cappola, Jacob T. Gutsche, Pavan Atluri, Nimesh D. Desai, Michael A. Acker, Gregory R. Grant, Richard J. Schwab, Ilene M. Rosen, Garret A. Fitzgerald

Division of Cardiology Faculty Papers

Postoperative clinical care is prone to circadian desynchronization that may influence health outcomes. In an exploratory, feasibility-oriented and signal-exploration effort, we collected 1.8 million data points using 11 remote sensors during preoperative, in-hospital and post-discharge settings in 13 elective cardiac surgery patients (5.2% enrolled from 252 screened). We found that room traffic continued during nighttime with ≥1 visit/h. Sound levels exceeded the recommended 45 dBA threshold (51.9 ± 3.3 vs. 48.3 ± 4.2 dBA during nighttime). Brightness dropped at night (89.9 ± 87.7 to 3.7 ± 9.8 lux), but bright light exposures occurred. Ambient room temperature lacked sleep-inducing diurnal variability. …


Inc3vits Model: A Hybrid Architecture To Accelerate And Reduce Complexity For The Deepvariant Model For Variant Calling, Mustafa Al-Saffar, Sura Z. Al Rashid Apr 2026

Inc3vits Model: A Hybrid Architecture To Accelerate And Reduce Complexity For The Deepvariant Model For Variant Calling, Mustafa Al-Saffar, Sura Z. Al Rashid

Karbala International Journal of Modern Science

Deep learning has revolutionized genomic variant calling, yet the computational cost of current systems continues to limit scalability. We present a controlled efficiency study of DeepVariant-style pileup architectures under identical training and inference conditions, comparing architectural downsizing with a hybrid CNN–local attention design. Inc3ViTs pairs a streamlined InceptionV3 stem with a lightweight local attention head based on patch tokenization and windowed self-attention, enabling a direct comparison with a CNN-only reduced Inception baseline. Across whole-genome and whole-exome short-read datasets, Inc3ViTs reduces training time by ~40–50% and reduces inference runtime relative to the original DeepVariant. The CNN-only baseline indicates that most speedups …


Construction Of China’S Marine Protected Area System In 15th Five-Year Plan, Ke Duan, Danhong Chen, Keqiang Li, Limin Han, Zhengyan Liu, Dongliang Lu, Xiulin Wang Apr 2026

Construction Of China’S Marine Protected Area System In 15th Five-Year Plan, Ke Duan, Danhong Chen, Keqiang Li, Limin Han, Zhengyan Liu, Dongliang Lu, Xiulin Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The establishment of the marine protected area (MPA) system constitutes a critical component of the national initiative to comprehensively advance the development of a nature reserve system centered on national parks. This study explores on domestic and international development trends from aspects such as conservation strategies, international policies, high seas protection, and development trends. It also sorts out and analyzes the construction status of marine protected area systems in China and the United States. Centering on issues in China related to spatial layout, management systems, policies and laws, scientific research support, high seas governance, and land-sea management, the study puts …


Psoas Muscle Volume Asymmetry, Not Attachment Site Asymmetry, Is Associated With Chronic Low Back Pain Status, Kassity D. Clay Apr 2026

Psoas Muscle Volume Asymmetry, Not Attachment Site Asymmetry, Is Associated With Chronic Low Back Pain Status, Kassity D. Clay

Theses and Dissertations

Chronic low back pain (CLBP) is a leading cause of disability worldwide, with increasing evidence implicating neuromuscular factors such as muscle asymmetry in its pathophysiology. The psoas major muscle (PMM), a key contributor to lumbar spine stability, has been comparatively under-investigated despite its biomechanical importance. PURPOSE: To determine whether right-to-left differences in PMM volume and attachment site asymmetry are associated with CLBP; to evaluate whether ODI, IPAQ, and age are associated with PMM volume imbalance; and to assess whether combined PMM volume and attachment asymmetry are associated with CLBP. METHODS: A retrospective secondary analysis was conducted using lumbar MRI data …


Tracing Microplastics From Polymer-Coated Urea: Urban To Agricultural Pathways And Environmental Fate, Caden Joseph Seely Apr 2026

Tracing Microplastics From Polymer-Coated Urea: Urban To Agricultural Pathways And Environmental Fate, Caden Joseph Seely

Theses and Dissertations

Polymer-coated urea (PCU) is widely used as a slow-release nitrogen (N) fertilizer because it improves N use efficiency and reduces losses through leaching, denitrification, and volatilization. However, the polymer coating raises concerns about potential microplastic (MP) transport to surface waters following fertilizer application. This thesis evaluates the off-site transport of MPs and associated nutrient and sediment losses from PCU in both urban landscape and agricultural systems. In the urban landscape study, treatments included sod, mulched beds, and water-efficient ground cover receiving uncoated urea, PCU, or liquid slow-release N at 225 kg N ha⁻¹ (with reduced rates for beds and ground …


An Integrative Description Of Euscorpius Diagorasi Sp. N. From Rhodes, Greece (Scorpiones: Euscorpiidae), Konstantinos Kalaentzis, Francesco Frigioni, Eliza Kaitetzidou, Alessio Iannucci, Alexandros Triantafyllidis Apr 2026

An Integrative Description Of Euscorpius Diagorasi Sp. N. From Rhodes, Greece (Scorpiones: Euscorpiidae), Konstantinos Kalaentzis, Francesco Frigioni, Eliza Kaitetzidou, Alessio Iannucci, Alexandros Triantafyllidis

Euscorpius

The genus Euscorpius Thorell, 1876 comprises a diverse and taxonomically challenging group of scorpions in the Mediterranean, with Greece representing one of its principal centers of diversity. In this study, we provide an integrative description of Euscorpius diagorasi sp. n., a new species from Rhodes Island, Greece. The new species is described on the basis of adult male and female morphology and mitochondrial COI sequence data. It is a small oligotrichous species characterized by a total length of approximately 21–25 mm, pale yellow to light brown coloration with darker reddish-brown pedipalps, pectinal tooth count of 8 in the male …


Effects Of Preslaughter Fasting On Ph And Bacterial Contamination In Akkaraman And Anatolian Merino Sheep, Sai̇m Boztepe, Özcan Şahi̇n, Talha Demi̇rci̇, Gi̇zem Coşkun, İbrahi̇m Ayteki̇n, İsmai̇l Keski̇n Apr 2026

Effects Of Preslaughter Fasting On Ph And Bacterial Contamination In Akkaraman And Anatolian Merino Sheep, Sai̇m Boztepe, Özcan Şahi̇n, Talha Demi̇rci̇, Gi̇zem Coşkun, İbrahi̇m Ayteki̇n, İsmai̇l Keski̇n

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of the preslaughter fasting on pH and bacterial contamination in Akkaraman and Anatolian Merino sheep. Included in the study were 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that were fasted for 24 h prior to slaughter, and a further 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that continued to be fed until slaughter as a control group. The total mesophilic aerobic bacteria (TMAB) measured at 0 and 24 h in the fasting Akkaraman and Anatolian Merino sheep were 4.87/4.79 and 4.75/5.57 log CFU/g, respectively, and the corresponding Enterobacteriaceae …


The Role Of Pten Subcellular Localization In Neuronal Development And Autism Spectrum Disorder, Nicole Desmet Apr 2026

The Role Of Pten Subcellular Localization In Neuronal Development And Autism Spectrum Disorder, Nicole Desmet

Dartmouth College Ph.D Dissertations

Autism spectrum disorders (ASD) are genetically heterogeneous neurodevelopmental conditions that nevertheless converge on altered neuronal connectivity and circuit function. A central unresolved problem in the field is how diverse genetic perturbations, acting at different biological levels and developmental stages, give rise to shared neurodevelopmental outcomes. This dissertation addresses this problem by examining how gene function, subcellular signaling, and developmental context interact to shape neuronal morphology and circuit-relevant phenotypes.

Cell-autonomous mechanisms regulating neuronal morphology are examined through the ASD risk gene Phosphatase and Tensin Homolog (PTEN) in developing dentate gyrus granule neurons. Selective biasing of PTEN to defined intracellular compartments in …


G1p3 Dysregulates Interferon-Stimulated Gene Expression In Er (+) Breast Cancer Cells, Karina Santana Apr 2026

G1p3 Dysregulates Interferon-Stimulated Gene Expression In Er (+) Breast Cancer Cells, Karina Santana

Honors Theses

Even with advances in diagnosis and treatment, breast cancer remains the second leading cause of cancer-related death in women, with nearly 90% of fatalities linked to drug resistance driven by metastasis and recurrence. G1P3, an anti-apoptotic mitochondrial protein, is upregulated in breast cancer and has been associated with increased metastatic potential and poor prognosis. Recent findings show that G1P3 enhances interactions between Rab5-containing endosomes (RCEs) and mitochondria, and emerging evidence suggests that mitochondria play a critical role in initiating interferon (IFN) responses. Based on this, we hypothesized that G1P3-mediated interactions between RCEs and mitochondria promote interferon-stimulated gene (ISG) expression in …


Quantitative Proteomics For The Investigation Of Phosphoprotein Phosphatase 1 And 3 Substrate Specificities, Galini Poimenidou Apr 2026

Quantitative Proteomics For The Investigation Of Phosphoprotein Phosphatase 1 And 3 Substrate Specificities, Galini Poimenidou

Dartmouth College Ph.D Dissertations

Reversible phosphorylation is a crucial post-translational modification (PTM) that modulates a variety of signaling pathways intracellularly, with aberrant protein phosphorylation being a hallmark of many human diseases. Kinases, which catalyze phosphorylation of their substrates, have been extensively studied in the context of the signaling pathways they regulate and their effects on cellular processes. In contrast, phosphoprotein phosphatases (PPPs), which catalyze the removal of phosphate groups from substrate proteins, have only recently come to the research spotlight. For a long time, protein phosphatases were deemed unspecific housekeeping enzymes, but they are now known to display exquisite substrate specificity. Phosphoprotein phosphatase 1 …


Semiochemicals And Odorant Receptors Underlying Potato Cultivar Susceptibility And Resistance To Potato Tuber Moth, Ruipeng Chen, Wangtao Hu, Qin Hu, Junjie Yan, Jiao Yin, Fathiya M. Khamis, Yulin Gao, Walter S. Leal Apr 2026

Semiochemicals And Odorant Receptors Underlying Potato Cultivar Susceptibility And Resistance To Potato Tuber Moth, Ruipeng Chen, Wangtao Hu, Qin Hu, Junjie Yan, Jiao Yin, Fathiya M. Khamis, Yulin Gao, Walter S. Leal

All Peer-Reviewed Publications

Infestation of potato by the potato tuber moth (Phthorimaea operculella) varies markedly among cultivars, yet the chemical and molecular mechanisms underlying this variation remain poorly understood. Here, we combine field surveys, chemical ecology, functional genomics, and structural modeling to reveal how cultivar-specific volatile profiles shape moth oviposition behavior and pest outcomes. Field and laboratory assays identified marked differences in adult attraction, oviposition, and larval damage among potato cultivars, which correlated with distinct blends of emitted volatile organic compounds (VOCs). Behavioral analyses revealed that among other VOCs, trans-nerolidol and β-ionone act as attractants, whereas 3-carene and benzyl tiglate function as oviposition …


Evaluating Ai-Driven Sustainable Neuro-Urbanism Through A Human-Centered Framework: The Case Of Ras Elbar City, Egypt, Esraa Elazab, Ahmed Eltawil Apr 2026

Evaluating Ai-Driven Sustainable Neuro-Urbanism Through A Human-Centered Framework: The Case Of Ras Elbar City, Egypt, Esraa Elazab, Ahmed Eltawil

Mansoura Engineering Journal

This study applies and evaluates a previously developed human-centered framework for AI-driven sustainable neuro-urbanism through a case study of Ras Elbar City, Egypt. Building on earlier conceptual research that integrated artificial intelligence (AI), neuroscience-informed design, and sustainability principles, this paper seeks to test the framework’s practical relevance in the context of a developing coastal city. Using qualitative evaluation methods, including field observation and spatial assessment, the research examines twelve key urban design elements such as green spaces, mobility networks, lighting, and soundscapes. Each element is analyzed across three dimensions: neuro-urbanism goals, AI integration, and sustainability outcomes. The findings show that …


Mechanistic Insights Into E. Coli Recovery From Growth Arrest, Ahmed H. Hassan, Yuko Nakano, Howard Gamper, Isao Masuda, Ludmila Vesela, Matyas Pinkas, Sathya Narayanan Nagarajan, Jonathan Dworkin, Gregor Blaha, Ya-Ming Hou, Gabriel Demo Apr 2026

Mechanistic Insights Into E. Coli Recovery From Growth Arrest, Ahmed H. Hassan, Yuko Nakano, Howard Gamper, Isao Masuda, Ludmila Vesela, Matyas Pinkas, Sathya Narayanan Nagarajan, Jonathan Dworkin, Gregor Blaha, Ya-Ming Hou, Gabriel Demo

Department of Biochemistry and Molecular Biology Faculty Papers

Bacteria survive hostile conditions by shutting down protein synthesis, but how they restart growth remains poorly understood. Here, we use an E. coli ΔrimM strain, which exhibits a prolonged growth arrest, as a model to investigate how bacteria recover from this state and restore protein synthesis. RimM is a conserved ribosome maturation factor for the 3'-major (head) domain of the 16S rRNA within the bacterial 30S subunit. The loss of RimM causes a longer delay in recovery than other 30S maturation factors, including RbfA. Cryo-EM analysis of ΔrimM ribosomes suggests a delayed recruitment of ribosomal proteins to the 30S head …


Redox Reprogramming In Neurogenesis: Candidate Developmental Switches And Targets Of Oxidative Toxicity In The Redox Proteome, Ryan Jacob Summerhays Apr 2026

Redox Reprogramming In Neurogenesis: Candidate Developmental Switches And Targets Of Oxidative Toxicity In The Redox Proteome, Ryan Jacob Summerhays

Theses and Dissertations

Neurogenic differentiation requires coordinated redox regulation, yet how reversible cysteine oxidation is remodeled at proteome scale during this process remains poorly defined. Here, we asked whether differentiation is associated with selective, site-specific changes in reversible cysteine oxidation and whether oxidative stress reveals developmentally conditioned vulnerabilities within this redox landscape. To address this, we applied a discovery-oriented, proteome-scale redox profiling strategy that quantifies condition-dependent changes in reversible cysteine oxidation using CysPAT labeling, phosphopeptide enrichment, and multiplexed TMT mass spectrometry. Neurogenic differentiation was characterized by reproducible, bidirectional, and highly site-specific remodeling of reversible cysteine oxidation at discrete regulatory nodes, as well as …


A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink Apr 2026

A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink

Faculty, Staff and Student Publications

While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …


Hydrologic History Regulates Microbial Biofilm Diversity And Ecosystem Function, Allison R. Rober, Leah C. Reese, Shawn P. Brown, Katherine D. Mcmahon, Stilianos Louca, Jillian Cieslik, Evan Kane, Merritt R. Turetsky, Kevin H. Wyatt Apr 2026

Hydrologic History Regulates Microbial Biofilm Diversity And Ecosystem Function, Allison R. Rober, Leah C. Reese, Shawn P. Brown, Katherine D. Mcmahon, Stilianos Louca, Jillian Cieslik, Evan Kane, Merritt R. Turetsky, Kevin H. Wyatt

Michigan Tech Publications

Aquatic biofilms are an understudied component of northern peatlands and are expected to play a more prominent role in ecosystem processes in areas where aquatic habitat is expanding. The goal of this study was to investigate how hydrologic history influences biofilm diversity and functional genes. This study was conducted in a long-term water table manipulation that simulates drought (lowered water table treatment) and flooding (raised water table treatment) conditions relative to a control treatment (no manipulation). We used a combination of metabarcoding and metagenomic approaches to (1) examine the diversity of eukaryotic algae, cyanobacteria, bacteria and fungi within the biofilm …


Systematic Design And Optimization Of Porous Bone Plates Using Taguchi Method And Finite Element Analysis, Aliaa A. Farraj, Tawakol A. Enab, Hanan M. Amer, Mostafa A. Elbahloul Apr 2026

Systematic Design And Optimization Of Porous Bone Plates Using Taguchi Method And Finite Element Analysis, Aliaa A. Farraj, Tawakol A. Enab, Hanan M. Amer, Mostafa A. Elbahloul

Mansoura Engineering Journal

Solid bone fixation plates, although clinically effective, often induce stress shielding and impair periosteal blood flow due to their mismatch in stiffness with cortical bone. To overcome these limitations, this study proposes lattice-engineered porous bone plates designed to balance mechanical integrity and biological compatibility. A systematic parametric investigation was conducted by varying three design variables: crystal structure type (diamond, fluorite, and gyroid), porosity levels (50%, 70%, and 90%), and structure layout. Three-dimensional models were developed using nTopology, and finite element analysis (FEA) was performed under a static compressive load to evaluate stress distribution. A Taguchi L9 orthogonal array was employed …


Changes In Depression, Eating, Sleep, And Emotion Regulation In Air Force Rotc Cadets After The 12-Wk Star Training Program, Antonella V. Schwarz, Hunter Haynes, Sheena Puleali’I, Jacob Mota, Molly F. Johnson, Maria G. Kaylor, Andrew Addison, Robyn Braun-Trocchio, Austin J. Graybeal Apr 2026

Changes In Depression, Eating, Sleep, And Emotion Regulation In Air Force Rotc Cadets After The 12-Wk Star Training Program, Antonella V. Schwarz, Hunter Haynes, Sheena Puleali’I, Jacob Mota, Molly F. Johnson, Maria G. Kaylor, Andrew Addison, Robyn Braun-Trocchio, Austin J. Graybeal

Faculty Publications

Introduction: – Reserve Officer Training Corps (ROTC) cadets must balance collegiate demands with military preparation, leaving them vulnerable to psychological stressors. While structured strength and conditioning (S&C) programs enhance physical readiness, their impact on psychological health in cadet populations remains unclear. This study evaluated changes in depression, eating behaviors, sleep quality, and emotion regulation during a 12-wk S&C program. Methods: – Forty-nine U.S. Air Force ROTC cadets (21 female, 28 male; age: 20 ± 2 yr; body mass index: 24.2 ± 4.4 kg·m−2; body fat %: 27.1 ± 9.0%) completed the Supporting Tactical Athlete Readiness (STAR) program, a …


Amyotrophic Lateral Sclerosis Risk Perceptions And Patient Burden, John William Glisson Apr 2026

Amyotrophic Lateral Sclerosis Risk Perceptions And Patient Burden, John William Glisson

Doctoral Dissertations and Projects

This quantitative, non-experimental, cross-sectional correlational study examined relationships among perceived environmental risk factors, depressive symptoms, and functional symptom burden in adults diagnosed with Amyotrophic Lateral Sclerosis (ALS). ALS is a progressive neurodegenerative condition with an unclear etiology, and some individuals attribute the diagnosis to environmental exposures such as pesticides or military service. The purpose of this study was to assess whether environmental risk perceptions were associated with depressive symptoms or functional impairment, and whether depressive symptoms were associated with functional status. Participants were recruited through online ALS support networks and advocacy organizations, resulting in a final sample of 145 adults …


Development, Validation, And Comparative Evaluation Of A Rheotaxis-Based Microfluidic Device To Isolate A Subpopulation Of High-Performance Human Spermatozoa, Charlene S. Fournier Apr 2026

Development, Validation, And Comparative Evaluation Of A Rheotaxis-Based Microfluidic Device To Isolate A Subpopulation Of High-Performance Human Spermatozoa, Charlene S. Fournier

Electronic Theses and Dissertations 2020 - Present

Fertility has declined over the past decades, and male infertility is now recognized as contributing equally to the need for Assisted Reproductive Technologies (ART). Current clinical sperm processing methods rely on multiple centrifugation steps, which are time- and labor-intensive and may be detrimental to spermatozoa. Therefore, improved methodologies are needed to select functional, healthy spermatozoa while mimicking natural sperm selection. Microfluidics has expanded in reproductive biology and offers an efficient approach to selecting spermatozoa based on progressive motility and rheotaxis—their natural ability to swim against a constant flow. In this study, I developed a rheotaxis-based microfluidic device to isolate highly …


Evaluating Impact Of Sustainability Practices And Operational Efficiency On Firm Value In Indonesia’S Mining Sector, Erika Windyasari, Yosman Bustaman Apr 2026

Evaluating Impact Of Sustainability Practices And Operational Efficiency On Firm Value In Indonesia’S Mining Sector, Erika Windyasari, Yosman Bustaman

Journal of Environmental Science and Sustainable Development

Sustainability practices are increasingly prominent in investor assessments of firm value Nevertheless, empirical evidence regarding which specific environmental practices are incorporated into capital market valuations remains inconclusive, particularly within mining sectors in emerging markets. This study investigates the correlation between sustainability practices energy efficiency, water management, waste management, renewable energy adoption and environmental quality (PROPER rating) together with operational efficiency and firm value in Indonesian listed mining firms. The analysis uses panel data for 23 firms over 2017–2023. Firm value is measured by Tobin’s Q, while operational efficiency is measured using Data Envelopment Analysis (DEA). The correlation is estimated using …


New Species Of Kronosvirus Bacteriophages That Infect Caulobacter Strain Cbr1, Tannaz Mohammadi, Austin Millwood, Maherah Shaik, Bert Ely Apr 2026

New Species Of Kronosvirus Bacteriophages That Infect Caulobacter Strain Cbr1, Tannaz Mohammadi, Austin Millwood, Maherah Shaik, Bert Ely

Faculty Publications

Caulobacter segnis strain CBR1 enhances the germination rate and total biomass of Arabidopsis plants. Since bacteriophages are usually present in the rhizosphere, we isolated three additional bacteriophages, designated TMCBR2, TMCBR3, and W2, that can replicate using CBR1 as the host strain. The genome sizes and morphologies of the new phages were similar to those of the previously isolated Kronos phage, and when we compared the nucleotide sequence of these new phage genomes, we found only minor differences among the four phage genomes. Pairwise sequence comparisons indicated that the phage genomes should be grouped into three separate species within Kronosvirus genus. …