Digital Commons Network^™

Terrestrial Gartersnake (Thamnophis Elegans) Consuming A Western Meadow Vole (Microtus Drummondii) In The Sangre De Cristo Mountains Of New Mexico, Joseph W. Paysen, Peggy M. Huss, Jacob C. Cooper, Lance J. Bernal, Carter Kruse, Keith Geluso

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The Terrestrial Gartersnake (Thamnophis elegans) is a dietary generalist occurring in the western half of the United States, southwestern Canada, and northern Mexico. Terrestrial Gartersnakes are known to consume a variety of small mammals, including voles (Microtus). Herein we report on an observation of the Terrestrial Gartersnake consuming a Western Meadow Vole (Microtus drummondii). On 27 June 2025, we captured a large adult Terrestrial Gartersnake underneath a log just upstream of a North American Beaver (Castor canadensis) dam on the Vermejo River, Colfax County, New Mexico that regurgitated a partially digested adult …

Biofunctional Characterization Of A Polyherbal Formulation, Muhammad Ameer Qarib Naqvi, Iqra Saleem, Fatma Hussain

Journal of Bioresource Management

Polyherbal formulations (PHFs) have greater medicinal importance due to their enhanced bioactivities. To check whether a combination of several plants enhances bioactivities, the current study was designed. Methanol, aqueous and n-hexane solvents were used to prepare PHF of Syzgium cumini, Origanum vulgare, Aloe vera barbadensis Miller and Gymnema sylvestre. DPPH (2, 2-diphenyl-1-picrylhydrazyl scavenging) assay was used to analyze antioxidant activity. The total phenolic content (TPC) and total flavonoid content (TFC) estimations were done by Folin-Ciocalteu reagent and AlCl₃ colourimetric techniques, respectively. Bactericidal activity was measured by agar well diffusion method, anti-diabetic profile was assessed by …

Impact Of Optimized Irrigation Scheduling On Wheat Growth, Yield And Water Use Efficiency Under Arid Conditions, Muhammad Arshad Khan, Ashiq Saleem, Muhammad Mansoor, Abdul Fatah Soomro, Haroon Shahzad

Journal of Bioresource Management

Improving water use efficiency is crucial since, in Pakistan, water is the main resource that limits crop productivity. A field study was conducted using a Randomized Complete Block Design (RCBD) with four replicates at the research farm of the Arid Zone Research Centre, Dera Ismail Khan, to determine the effects of altered irrigation schedules on wheat growth, yield and water use efficiency (WUE). LI₁ and LI₂ (90 and 60 mm irrigation) at crown root, tillering and milking stages, LI₃ (60 mm irrigation) at crown root and tillering stages and (90 mm irrigation) at milking stage, and LI …

Hubungan Kehamilan Usia Remaja Dengan Kelahiran Prematur Di Rsud Cengkareng Jakarta Barat Tahun 2022: Sebuah Studi Kohort Retrospektif, Anna Triana, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Premature birth is leading causes of neonatal mortality. According to the World Health Organization (WHO), global premature birth rates reached 9.9% in 2020, it’s rising compared to preterm birth rates in 2010. One of the risk factors for preterm birth is the mother's age, which pregnant adolescents are more at risk of giving birth to preterm babies due to physiological, psychological, and socioeconomic immaturity. This study is an analytical study with a retrospective cohort design to determine the relationship between adolescents pregnancy and preterm birth. This study was conducted in Cengkareng General Hospital West Jakarta using patient’s medical record data. …

Everyday Practices In Seed Sovereignty, Tapiwa Singini, Wu Xu

Journal of Nonprofit Innovation

Seed sovereignty is increasingly recognized as central to debates around food security, biodiversity, and rural livelihoods, particularly in the Global South. In Malawi, seed is not merely an agricultural input but a carrier of memory, resilience, and political agency. This paper explores how smallholder farmers in rural Malawi engage in everyday acts of resistance to maintain seed sovereignty amidst expanding corporate influence, restrictive state policies, and climate variability. Based on 12 months of ethnographic fieldwork in Mchinji District, I employ a political ecology framework and peasant resistance theory to analyze the lived strategies of farmers. These include seed saving, informal …

Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇

Turkish Journal of Agriculture and Forestry

The nutritional adjustment of food products has gained popularity in recent years as consumer interest in healthy eating has increased. Cake is a widely consumed cereal-based product containing such key nutrients as carbohydrate, fat, protein, fiber, vitamins, and minerals. In the present study, crust and crumb color, specific volume, microstructure, antimicrobial activity, total phenolic content, antioxidant activity, and sensory analyses were evaluated in four cake groups: a control cake (IT0) and cakes supplemented with 1% (IT1), 3% (IT2), and 5% (IT3) nettle seed powder. The addition of nettle seed powder to the cakes significantly reduced the crust (L*, a* and …

Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li

Turkish Journal of Agriculture and Forestry

Spectral analysis methods can nondestructively assess the quality of agricultural products but are limited by imaging speed and equipment costs. Therefore, they have not yet been fully integrated into engineering practices. This paper presents JujubeNet, a two-stage hyperspectral reconstruction model for detecting moisture content in jujubes. The first stage utilizes a generative pretrained Pix2Pix generative adversarial network (GAN) to generate RGB images of jujubes that mimic real camera styles and are pixel-to-pixel aligned with hyperspectral images. The second stage uses a transformer-based spectral reconstruction model to achieve hyperspectral reconstruction. Additionally, we developed a moisture content detection model based on hyperspectral …

Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen

Turkish Journal of Biology

Background/aim: Oxidative stress is a major contributor to melanocyte dysfunction and hair graying by impairing key signaling pathways. Eucommia ulmoides bark extract (EUE), rich in antioxidant phytochemicals, has shown potential in combating oxidative damage. This study investigated the protective and promelanogenic effects of EUE under hydrogen peroxide (H₂O₂)-induced oxidative stress, with a focus on the Wnt/β-catenin signaling pathway. Materials and methods: An oxidative stress model was established using B16 cells and a C57BL/6 mouse hair follicle model. Results: EUE significantly improved melanocyte survival and reduced intracellular reactive oxygen species (ROS). Mechanistically, EUE activated the Wnt/β-catenin pathway, leading to upregulation of …

Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman

Turkish Journal of Agriculture and Forestry

Perfluoroalkyl substances (PFASs) are synthetic organic compounds that have not been extensively studied in natural environments. The current study aimed to explore how PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorotetradecanoate (PFTeDA), and perfluorobutanoate (PFBA), affect rice plants and influence their metabolism. These substances had a notable impact on root and shoot growth, reducing fresh and dry weights across various treatments compared to the control. These attributes were the least affected by PFOS treatment. PFBA treatment had significant adverse effects on chlorophyll a, b, and total chlorophyll levels, followed by the effects of PFHxA and PFTeDA. …

Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak

Turkish Journal of Agriculture and Forestry

Sugar bean (Phaseolus vulgaris L.) is a legume of notable nutritional and functional value, and its genotypes have substantial variation in bioactive compounds, antioxidant activity, mineral composition, and enzyme inhibition properties. This study aimed to comprehensively evaluate the biochemical and functional diversity of 10 sugar bean genotypes using data mining algorithms to identify superior candidates for functional food and nutraceutical development. Associations between the phytochemical profiles of sugar bean genotypes and their bioactivity, antioxidant capacity, and enzyme inhibition were modeled with classification and regression trees (CART), random forests (RF), and multivariate adaptive regression splines (MARS), while one-way ANOVA quantified varietal …

Effects Of Auricular Point Acupressure On Inflammatory Signaling In Chronic Low Back Pain: A Secondary Analysis Of A Randomized Controlled Trial, Nada Lukkahatai, Hongyu Wang, Xinran Huang, Wanqi Chen, Hulin Wu, Jennifer Kawi, Zhiyin Yu, Constance M Johnson, Paul Christo

Faculty, Staff and Student Publications

Objective: Auricular point acupressure (APA) has shown promise for pain relief, but its biological mechanisms remain unclear. This study examined the effects of APA on inflammatory cytokines and explored the relationships between changes in inflammatory markers and clinical outcomes in older adults with chronic low back pain (cLBP).

Method: This secondary analysis utilized plasma samples from a three-arm randomized controlled trial (RCT) (NCT03589703) with 272 participants aged 65 years and older with cLBP. The participants were randomly assigned (1:1:1) to the targeted APA (T-APA), nontargeted APA (NT-APA), or education control (CG) groups for four weeks. Cytokine levels were …

Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük

Turkish Journal of Agriculture and Forestry

Citrus is one of the most important and widely cultivated fruit crops globally. However, its productivity is increasingly threatened by various diseases, with bacterial infections being particularly the most destructive. Among these, citrus canker, caused by Xanthomonas axonopodis pv. citri (Xac), poses a significant challenge, requiring effective management strategies. Traditional approaches have shown limited success, but nanotechnology has emerged as a promising alternative for disease control. In this study, Xanthomonas spp. was isolated from two locations: Koont Farm and the National Agricultural Research Centre (NARC) citrus orchards in Islamabad, Pakistan. The isolates were identified through morpho-biochemical methods. Moreover, three Bacillus …

Effects Of Different Mixing Ratios Of Common Vetch And Oats On Forage Yield And Quality, Meli̇h Okcu, Sedat Severoğlu, İbrahi̇m Kavuncu

Turkish Journal of Agriculture and Forestry

This study investigates the optimal mixing ratios of common vetch (Vicia sativa L., CV) and oats (Avena sativa L., O) for enhanced forage yield and quality in the ecological conditions of Erzurum Province. The research was conducted over two growing seasons with three replications in a randomized complete block design (RCBD). Specifically, three common vetch cultivars (Gülhan, Albayrak, Kubilay) and one oat cultivar (Kupa) were evaluated by sowing as sole crops and in different ratios (25% vetch + 75% oat, 50% vetch + 50% oat, 75% vetch + 25% oat). The analyzed parameters included hay forage yield (HFY), dry matter …

Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang

Turkish Journal of Agriculture and Forestry

This study investigates the impact of long-term fertilization modes on crop health and productivity using unmanned aerial vehicle (UAV)-assisted monitoring and a Q-learning-based approach for optimized fertilization strategies. An approximate state-matching Q-learning algorithm was developed to improve the efficiency of agricultural UAVs in fertilization tasks. The spatiotemporal patterns of cultivated land productivity under different fertilization regimes were analyzed in a long-term experiment. An evaluation system for cultivated land health productivity was established. The results indicated that the Q-learning algorithm enabled UAVs to achieve efficient task completion. QLASM outperformed traditional methods on all metrics. QLASM achieved a 92% task completion rate …

Short- Term Effects Of Cypermethrin Pesticide On Nutrient Levels And Microbial Communities In Tropical Soil Of Uganda, Mama N. Simon

Tanzania Journal of Science

Cypermethrin is an insecticide widely used by farmers in Uganda to control pests and diseases. The widespread use leads to biomagnification, affecting humans and the ecosystem. This study examined the short-term effects of cypermethrin on soil macronutrients (N, P, K), meso-nutrients (Ca, Mg), and microbial communities (bacteria, fungi, and actinomycetes) in tropical Ugandan soils. Soil samples treated with cypermethrin and control were collected and analysed using standard methods of flame photometry for potassium (K), atomic absorption spectroscopy for calcium and magnesium, Wet-acid oxidation for nitrogen and phosphorus, and standard plate count techniques for microbial populations. The study used a Randomized …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Gamma Secretase Inhibitors, Dapt And Mk0752, Exhibit Synergistic Anticancer Effects With Cisplatin And Docetaxel In 2d And 3d Models Of Breast Cancer, Kübra Telli̇, Johannes Gubat, Padraig D'Arcy, Özden Yalçin Özuysal

Turkish Journal of Biology

Background/aim: Breast cancer remains a major malignancy among women, and severe side effects and the development of acquired drug resistance frequently hinder current therapeutic strategies. The Notch signaling pathway, a key regulator of cell fate, is commonly dysregulated in breast cancer and associated with poor prognosis. Gamma-secretase inhibitors (GSIs) block Notch receptor activation and have shown potential anticancer efficacy. This study aimed to investigate the synergistic activity of two commonly used GSIs, DAPT and MK0752, combined with docetaxel or cisplatin in both 2D and 3D breast cancer models.Materials and methods: Triple-negative, highly metastatic MDA-MB-231 and ER+/PR+ MCF-7 breast cancer cell …

Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu

Turkish Journal of Biology

Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …

Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Taxane resistance remains a significant challenge in the effective treatment of castration-resistant prostate cancer (CRPC). Given the association of epigenetic regulation with chemotherapy resistance and cancer progression, this study aims to identify epigenetic vulnerabilities in two CRPC cell lines (DU145 and 22Rv1) established as resistant to two different taxanes, docetaxel (Dtx) and cabazitaxel (Cbz), using a small-molecule screening approach. Materials and methods: A small-molecule library targeting epigenetic regulators, including histone deacetylases (HDAC), histone methyltransferases, histone demethylases, bromodomain proteins, deoxyribonucleic acid methyltransferases, protein arginine deiminase, and histone acetyltransferase was utilized. Drug screening was performed on parental and taxane-resistant CRPC cell …

In Vitro Antibiofilm Activity Of Tyrosol Against Single And Dual-Species Biofilms Of Candida Tropicalis And Streptococcus Mutans, Zarifeh Adampour, Betül Yilmaz Öztürk, Bükay Yeni̇ce Gürsu, İlknur Dağ

Turkish Journal of Biology

Background/aim: The cross-kingdom biofilm structure formed by Candida tropicalis and Streptococcus mutans may increase caries formation. The aim of this study was to evaluate the in vitro effect of the exogenous tyrosol on single- and dual-species biofilms as well as planktonic cultures formed by C. tropicalis and S. mutans. Materials and methods: The antimicrobial efficacy of tyrosol was evaluated through broth microdilution, colony-forming unit (CFU) enumeration, and XTT reduction tests to assess cell viability and metabolic activity. Transmission electron microscopy (TEM) was used to examine ultrastructural changes in planktonic cells. Biofilm dynamics were visualized via scanning electron microscopy (SEM) and …

Mir-22 Inhibits The Proliferation, Migration, And Invasion Of Human Cd133-Positive Glioblastoma Stem Cells, Sevi̇l Köse, Özlenen Özkan, Ömer Özkan

Turkish Journal of Biology

Background/aim: Glioblastoma multiforme (GBM) is one of the most aggressive and fatal malignancies of the central nervous system. Despite advancements in treatment strategies, effective therapies for GBM remain insufficient, necessitating further improvements. Notably, miR-22 has been found to be significantly downregulated in both glioblastoma tissues and cell lines. In this study, we aim to evaluate miR-22 expression levels in GBM (U87) and CD133-positive (CD133+) GBM stem cells (GSCs) and to investigate its effects on proliferation, colony formation, migration, invasion, and wound-healing in U87 and CD133+ U87 cells in vitro.Materials and methods: We isolated CD133+ U87 cells using magnetic-activated cell sorting …

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …

Corrigendum To “Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Diff Egulating The Differentiation Of Cd4+Il-10+T Cells Entiation Of Cd4+Il-10+T Cells Via Tar Via Targeting The Cr Geting The Crosstalk Between Nr Osstalk Between Nrf2 And Nf- F2 And Nf-Κb Signaling Pathways” [Turkish Journal Of Biology 49 (4) 2025 380-391], Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang

Turkish Journal of Biology

This corrigendum is to address an issue regarding the manuscript’s previous publication. The authors noticed that the representative flow cytometry image for the AAA group in Figure 3B, as well as the representative Histone H3 and β-actin Western blot bands in Figure 4A, were incorrectly used in the original published version of this paper and indicated that the relevant corrections do not affect the results or the conclusions of the study.To rectify this oversight and ensure the accuracy of the published work, the correct figures are included for your reference.

Link to the original article: https://doi.org/10.55730/1300-0152.2754

6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar

Indian Journal of Research in Homoeopathy

Background: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: …

Potency Dependent Angiogenic Effect Of Bellis Perennis On In Ovo Chick Chorioallantoic Membrane Assay, Jayanthdevan V, Winston Vargheese V, Anish Fathima K, Lohita S

Indian Journal of Research in Homoeopathy

Background: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis …

A New Dioecious Bush Tomato, Solanum Nectarifolium (Solanaceae), From The Northern Tanami Desert, Northern Territory, Australia, With Reassessment Of S. Ossicruentum And A Change In The Circumscription Of S. Dioicum, Christopher T. Martine, Kym Brennan, Jason T. Cantley, Aiden Webb, Geoffrey Newton

Faculty Journal Articles

A new species of functionally dioecious bush tomato from the “Solanum dioicum + S. echinatum group” of Solanum subgenus Leptostemonum is described. Solanum nectarifolium Martine & Brennan, sp. nov., is a member of the taxonomically challenging Solanum dioicum W.Fitzg. species complex in Australia and differs from other species in the group by the presence of prominent and conspicuous extrafloral nectaries on the abaxial leaf surfaces, a tinge of purple on the new growth and young fruiting calyces, and curved prickles on young stems. Although fairly well represented in herbarium collections, this new taxon has historically been treated as a …

Food Safety Concerns: A Review On Pathogenic Microbes Associated With Common Edible Insects, Anitha Philbert

Tanzania Journal of Science

This review explored the pathogenic microbes associated with common edible insects. With rising human populations and fluctuating food supplies, edible insects offer a rich source of protein, vitamins, and minerals and are culturally accepted in many regions. Despite their nutritional benefits, knowledge on microbial hazards associated with edible insects is fragmented. The review focuses on commonly consumed species, including Tenebrio molitor, Zophobas morio, Acheta domesticus, Gryllus bimaculatus, Locusta migratoria, Ruspolia differens, Bombix mori, Bunaea alcinoe, and Oryctes monoceros. A total of 43 pathogenic bacteria and 20 pathogenic fungi linked to these edible insect species were identified. The most frequently reported …

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …

Many Hands Make Stronger Work: Building Cross-Institutional Undergraduate Research Experiences Using Universal Design For Learning, Stephen Podowitz, Abigail Graham, Madison E. Greene, Sarah R. Johnson, Katherine Leonard, Margaret Vander Sys, Mariel A. Pfeifer

College of Life Sciences Faculty Papers

Designing an undergraduate research experience in which all team members can meaningfully contribute and experience growth can be challenging, especially for virtual teams working across institutions. For two years, the authors worked remotely as a team that included several undergraduate researchers in a highly involved research project. Through the partnership, the two principal investigators on the project were able to involve more undergraduates in research than they could individually, using a mentoring model that drew on Universal Design for Learning (UDL) principles to ensure students had opportunities for intellectual involvement in the research process. By working as an integrated team, …