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Full-Text Articles in Entire DC Network
Fungal Pathogen Control And Microbial Ecology: Insights From Soybean Seed Production, Samantha Rigo Segalin
Fungal Pathogen Control And Microbial Ecology: Insights From Soybean Seed Production, Samantha Rigo Segalin
Graduate Theses and Dissertations
This study evaluated the effects of planting date (PD), seed vigor, and chemical seed treatments on the plant stand and yield of two soybean cultivars with different maturity groups (MGs) across four locations in Arkansas from 2018 to 2021. Early planting in early May (early PD) led to higher plant stands and yields compared to late planting in early June (late PD). The interaction between planting date and cultivar was significant, with both cultivars showing higher plant stands on early planting dates. Seed vigor and seed treatment also significantly impacted plant populations; high-vigor seeds planted early resulted in better stands …
Oats – Essentials For Growing A Successful Crop, Department Of Primary Industries And Regional Development, Western Australia
Oats – Essentials For Growing A Successful Crop, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Oats in Western Australia are grown for grain, hay, grazing, or silage. Each year, between 250,000 and 350,000 hectares are sown for grain production. This page provides essential management practices for growing a successful oat crop.
Lactoferrin And Lysozyme To Promote Nutritional, Clinical And Enteric Recovery: A Protocol For A Factorial, Blinded, Placebo-Controlled Randomised Trial Among Children With Diarrhoea And Malnutrition (The Boresha Afya Trial), Ruchi Tiwari, Kirkby Tickell, Emily Yoshioka, Joyce Otieno, Adeel Shah, Barbra Richardson, Lucia Keter, Maureen Okello, Churchil Nyabinda, Indi Trehan
Lactoferrin And Lysozyme To Promote Nutritional, Clinical And Enteric Recovery: A Protocol For A Factorial, Blinded, Placebo-Controlled Randomised Trial Among Children With Diarrhoea And Malnutrition (The Boresha Afya Trial), Ruchi Tiwari, Kirkby Tickell, Emily Yoshioka, Joyce Otieno, Adeel Shah, Barbra Richardson, Lucia Keter, Maureen Okello, Churchil Nyabinda, Indi Trehan
Paediatrics and Child Health, East Africa
Introduction: Children with moderate or severe wasting are at particularly high risk of recurrent or persistent diarrhoea, nutritional deterioration and death following a diarrhoeal episode. Lactoferrin and lysozyme are nutritional supplements that may reduce the risk of recurrent diarrhoeal episodes and accelerate nutritional recovery by treating or preventing underlying enteric infections and/or improving enteric function.
Methods and analysis: In this factorial, blinded, placebo-controlled randomised trial, we aim to determine the efficacy of lactoferrin and lysozyme supplementation in decreasing diarrhoea incidence and improving nutritional recovery in Kenyan children convalescing from comorbid diarrhoea and wasting. Six hundred children aged 6–24 months with …
Ecosystem Effects Of Targeted Grazing With Sheep To Manage Cheatgrass, Madelyn Sorrentino
Ecosystem Effects Of Targeted Grazing With Sheep To Manage Cheatgrass, Madelyn Sorrentino
Boise State University Theses and Dissertations
Cheatgrass (Bromus tectorum) invasion is widespread across the Great Basin region of the United States and is expected to continue. Cheatgrass degrades ecosystem functioning, increases the risk of wildfire, and negatively affects rangeland-based agriculture and other land uses. Targeted grazing—the use of livestock to accomplish a vegetation management objective—has been suggested as a management practice that could combat cheatgrass invasion at the landscape level. However, knowledge of targeted grazing at a management-relevant scale and its effects on other vital ecosystem components, such as non-target plant species and soil properties, remains limited. To test the efficacy of sheep targeted …
Evaluating Margin Protection (Mp) Crop Insurance As A Risk Management Tool For Rice Producers In Arkansas, Kaleem Azmat Chattha
Evaluating Margin Protection (Mp) Crop Insurance As A Risk Management Tool For Rice Producers In Arkansas, Kaleem Azmat Chattha
Graduate Theses and Dissertations
Agricultural producers bear many risks, including production risks stemming from uncertainty in weather and pest pressure and price risks arising from market volatility. Federal Crop Insurance has become one of the most popular tools to manage these risks. While yield and revenue crop insurance tend to be the most popular production and price risk management tools provided by the government, participation in Margin Protection insurance lags far behind despite providing production, crop price, and input price risk protection. This study aims to uncover whether Margin Protection crop insurance is an effective risk management tool by estimating the optimal coverage level …
Leveraging Generative Ai For Sustainable Farm Management Techniques Correspond To Optimization And Agricultural Efficiency Prediction, Samira Samrose
Leveraging Generative Ai For Sustainable Farm Management Techniques Correspond To Optimization And Agricultural Efficiency Prediction, Samira Samrose
All Graduate Reports and Creative Projects, Fall 2023 to Present
Sustainable farm management practice is a multifaceted challenge. Uncovering the optimal state for production while reduction of environmental negative impacts and guaranteed inter-generational assets supervision needs balanced management. Also, considering lots of different factors (cost, profit, employment etc), the agricultural based management technique requires rigorous concentration. In this project machine learning models are applied to develop, achieve and improve the farm management techniques. This experiment ensures the resultant impacts being environment friendly and necessary resource availability and efficiency. Predicting the type of crop and rotational recommendations will disclose potentiality of productive agricultural based farming. Additionally, this project is designed to …
Effects Of Winter Ticks (Dermacentor Albipictus) On The Reproduction Of Utah Moose (Alces Alces Shirasi), Samuel D. Robertson
Effects Of Winter Ticks (Dermacentor Albipictus) On The Reproduction Of Utah Moose (Alces Alces Shirasi), Samuel D. Robertson
All Graduate Theses and Dissertations, Fall 2023 to Present
Moose (Alces alces) are the largest and only solitary members of the deer family. The species can be found across many northern regions around the world. Moose are considered to have high intrinsic, recreational and ecological value. In recent years, there have been concerns about declining moose populations in portions of the species circumpolar range. Moose in Utah (Alces alces shirasi) belong to the Shiras subspecies, which is the smallest of the four subspecies found in North America. Utah moose are the southernmost naturally occurring moose population in the world. The Utah Division of Wildlife Resources …
Relationship Between The Physical Properties And Oil Binding Capacity Of Fats, Melissa Abigail Marsh
Relationship Between The Physical Properties And Oil Binding Capacity Of Fats, Melissa Abigail Marsh
All Graduate Theses and Dissertations, Fall 2023 to Present
Fats play a significant role in shaping the characteristics of foods, influencing texture, mouthfeel, appearance, and nutritional attributes. An important property of fats is their ability to entrap liquid oil known as oil binding capacity (OBC). Poor OBC of fats frequently leads to shortened-shelf life of foods caused by quality issues due to unwanted chemical and physical changes. In natural nut butters without additives, low OBC often results in a visual oil layer forming at the surface. In filled chocolates such as truffles, pralines, and peanut butter cups this low OBC can result in unwanted textural and visual changes.
The …
Molecular Mechanisms Of Exercise-Stimulated Resolution Of Inflammation And Its Dietary Dependence., Ernesto H. Pena Calderin
Molecular Mechanisms Of Exercise-Stimulated Resolution Of Inflammation And Its Dietary Dependence., Ernesto H. Pena Calderin
Electronic Theses and Dissertations
Diet-induced obesity and adipose tissue (AT) inflammation that ensues sets the stage for systemic metabolic inflammation, disrupted insulin signaling, and eventual type 2 diabetes (T2D) development. At the center of this pathology lies a disruption in endogenous inflammation resolution pathways characterized by an imbalance in lipid mediator production (greater abundance of pro-inflammatory to pro-resolving lipids). Additionally, obese states are characterized by adrenergic deficiency, especially in response to physical activity. Inflammatory processes have been experimentally mitigated by either the pharmacological inhibition of pro-inflammatory signals (i.e., Leukotriene B4 (LTB4) and its receptor BLT1, which establishes a potent chemotactic stimulus …
Forage News [2024-08], University Of Kentucky
Transglutaminase Crosslinked Milk Protein Concentrate And Micellar Casein Concentrate: Impact On The Functionality Of Imitation Mozzarella Cheese Manufactured On A Small Scale Using A Rapid Visco Analyzer, Prafulla Salunke, Lloyd Metzger
Transglutaminase Crosslinked Milk Protein Concentrate And Micellar Casein Concentrate: Impact On The Functionality Of Imitation Mozzarella Cheese Manufactured On A Small Scale Using A Rapid Visco Analyzer, Prafulla Salunke, Lloyd Metzger
Dairy Science and Food Science Faculty Publications: 2022 to Present
In dairy-based imitation mozzarella cheese (IMC) formulations, intact casein is critical and imparts IMC with a firm and elastic, stringy, melted texture. Rennet casein (RCN) is the desired ingredient to provide intact casein in IMC and is preferred over milk protein concentrate (MPC) and micellar casein concentrate (MCC). Transglutaminase (TGase), a crosslinking enzyme, alters the physical properties of MPC or MCC and may change IMC functionality. The objective of this study was to determine the effect of TGase-crosslinked MPC and MCC powders on the functionality of IMCs. The TGase treatment included TGase at 0.3 (L) and 3.0 (H) units/g of …
Characterizing Oxylipins In Human Milk Extracellular Vesicles, Priscila Herrera
Characterizing Oxylipins In Human Milk Extracellular Vesicles, Priscila Herrera
Food Science (MS) Theses
Extracellular vesicles (EVs) are non-replicating lipid bilayer membrane-bound particle formed by a parent cell and secreted into the extracellular environment. EVs in human milk are bioavailable and influence physiologic pathways that may contribute to newborn growth and development. There is interest in the oxylipin content of EVs that may contribute to the bioavailability of EVs. This research aims to characterize the oxylipin content of human milk EVs. Centrifugation and precipitation were used to isolate EVs from human milk (n = 20). The Folch method was used to extract lipids, and liquid chromatography-mass spectrometry (LC– MS) was used to qualify and …
Physicians’ Attitude, Knowledge, And Perceived Control Towards The Use Of Exercise As A Form Of Preventive Medicine, Matthew Robert Warner
Physicians’ Attitude, Knowledge, And Perceived Control Towards The Use Of Exercise As A Form Of Preventive Medicine, Matthew Robert Warner
All-Inclusive List of Electronic Theses and Dissertations
Exercise is a component of physical activity that can aid in the reduction of deaths, lowering obesity rates, and chronic illness. However, many Americans are not meeting the recommended physical activity levels (Carlson, et al., 2018). Quality and accurate health information regarding physical activity is one way to help combat health disparities. Health professionals such as primary care physicians can aid in promoting this lifestyle modification. However, there are shortfalls in physicians’ knowledge of using exercise as a form of preventive medicine for chronic illness. Many medical programs have little to no training in exercise principles (Cardinal et al., 2015). …
Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan
Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan
Electronic Theses, Projects, and Dissertations
Childhood obesity remains a significant public health concern, with substantial implications for physical and mental well-being. This thesis aims to explore the intricate relationship between emotional eating and obesity among adolescents, with a focus on identifying emotional triggers and assessing their psychological impact. Utilizing a cross-sectional study design at a university in southern California, data were collected from two adolescents aged 13-18 years. Through surveys and body composition measurements, participants' emotional barriers to weight loss and readiness for change were assessed. The findings underscore the presence of varying degrees of emotional hurdles among adolescents with obesity, including depression, frustration, and …
Assessment Of American Tannin-Free Grain Sorghum As Feedstuff For Poultry: Nutrient Composition, Amino Acid Digestibility And Bird Performance, Santiago Sasia
Assessment Of American Tannin-Free Grain Sorghum As Feedstuff For Poultry: Nutrient Composition, Amino Acid Digestibility And Bird Performance, Santiago Sasia
All Dissertations
Given the rising cost of poultry diets, alternative ingredients like sorghum are crucial for maximizing returns without compromising product quality. Sorghum's drought tolerance and adaptability, along with its nutritional profile, make it a viable corn substitute. This dissertation examines the nutrient composition, amino acid digestibility, and performance of poultry fed with American tannin-free grain sorghum. Chapter II evaluates the impact of sorghum-based diets, with or without phytase superdosing, on broiler performance, including body weight, weight gain, feed intake, and feed conversion ratio. Results indicate that sorghum can replace corn without adverse effects on broiler performance. Chapter III explores the partial …
Identification Of Bacterial Transcriptomic Signatures In Breast Cancer Tissues Using Publicly Available Datasets, Rasaq Awosemo
Identification Of Bacterial Transcriptomic Signatures In Breast Cancer Tissues Using Publicly Available Datasets, Rasaq Awosemo
Master's Theses
Breast cancer remains a significant global health concern, with increasing evidence suggesting a link between bacterial infections and cancer progression. This study aims to identify bacterial transcriptomic signatures within breast cancer tissues using publicly available datasets. While previous work in our lab has extensively explored the role of Borrelia burgdorferi in cancer, this research broadens the focus to investigate the presence of various bacterial species across different breast cancer samples.
Employing advanced bioinformatics methodologies, including the STAR aligner and MetaPhlAn for metatranscriptomics analysis, we analyzed RNA-sequencing data from the Gene Expression Omnibus (GEO). Our findings reveal diverse bacterial communities within …
Environmental Physiology Of Medical Cannabis, F. Mitchell Westmoreland
Environmental Physiology Of Medical Cannabis, F. Mitchell Westmoreland
All Graduate Theses and Dissertations, Fall 2023 to Present
Cannabis (Cannabis sativa L.) is increasingly being cultivated for industrial and medical uses. Medical cannabis is grown for cannabinoids and terpenes, compounds that continue to show promising therapeutic potential. Cannabidiol (CBD) and delta-9- tetrahydrocannabinol (Δ9-THC) are the two most common cannabinoids, but more than 150 have been identified in cannabis. The 2018 Farm Bill federally legalized cannabis containing less than 0.3% THC and high-THC medical cannabis is legal in 38 states. There is a need to understand environmental effects on yield and quality to ensure safety and quality for medical use.
The cultivation of medical cannabis is centered around …
Identifying Genes Linked To Variation In Metabolic And Whole Plant Phenotypes Using Data From Genome Resequencing, Transcriptomics, And Metabolic Profiling Of A Field-Grown Maize Diversity Panel, Ramesh Kanna Mathivanan
Identifying Genes Linked To Variation In Metabolic And Whole Plant Phenotypes Using Data From Genome Resequencing, Transcriptomics, And Metabolic Profiling Of A Field-Grown Maize Diversity Panel, Ramesh Kanna Mathivanan
Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research
Maize metabolism is highly complex and influenced by genetic variation, yet the specific genes contributing to this variation and their links to non-metabolic traits remain less understood. To address this knowledge gap, we identified genes involved in maize metabolic variation and linked them to non-metabolic traits. We utilized a quadruplicate dataset of whole genome resequencing, transcriptomic, metabolic, and whole plant phenotype data from a single common field experiment of 660 diverse maize inbred lines. Leaf samples were collected shortly before flowering and analyzed using GC-MS for 26 metabolites. A Resampling Model Inclusion Probability Genome-Wide Association Study (RMIPGWAS) of approximately 2.6 …
Factors Influencing Adventitious Root Formation Of Floral Hemp In Propagation, Alexandra Carver
Factors Influencing Adventitious Root Formation Of Floral Hemp In Propagation, Alexandra Carver
All Theses
Commercial propagators have reported relatively poor propagation success, e.g., <75% rooting, for many hemp (Cannabis sativa) cultivars. These rooting percentages have a significant economic impact due to the wasted labor, space and supplies. Also, the market demands 100% of the propagation cells in a tray to be fully rooted, thus repairing and replacing poorly rooted or unrooted cuttings requires significant labor cost. The goal of this thesis was to evaluate several factors that influence adventitious root formation of hemp stem cuttings.
Chapter 2 describes an experiment conducted to identify rooting hormone treatments that could improve propagation success. Sixteen combinations of indole-3-butyric acid (IBA; 0, …
Influence Of Row Pattern And Prohexadione Calcium On Peanut (Arachis Hypogaea L.) Maturity And Profitability, Samantha N. Mehl
Influence Of Row Pattern And Prohexadione Calcium On Peanut (Arachis Hypogaea L.) Maturity And Profitability, Samantha N. Mehl
All Theses
Many newer peanut cultivars offer yield benefits but have larger canopies and are taking 10 or more days longer to reach desired maturity levels. Prohexadione calcium (PC) and twin row planting pattern have been reported to increase the amount of orange, brown or black pods compared to their respective alternatives. Four cultivars were selected and studied based on frequency of use in South Carolina then paired into an earlier maturing group that reached optimal maturity at 135 to 140 days after planting, and a later maturing group that reached optimal maturity at 150 or more days after planting.
Twin row …
Interactions Between High-Pressure Processing And Natural Antimicrobials In Ground White-Meat Chicken: An Analysis Of Microbial, Textural Charactheristics And Physicochemical Changes, Amalia M. Diaz Alejandro
Interactions Between High-Pressure Processing And Natural Antimicrobials In Ground White-Meat Chicken: An Analysis Of Microbial, Textural Charactheristics And Physicochemical Changes, Amalia M. Diaz Alejandro
All Theses
High Pressure processing is an innovative technique for preserving a wide variety of foods, including meat, and this method is increasingly used to satisfy consumer demand for quality food products. High-pressure treatment can impact, negatively or positively, various aspects of meat quality, including color, texture, protein denaturation, and microbial stability, particularly when food products are processed at ambient or low temperatures. By minimizing thermal exposure, appropriate high-pressure ranges help to prevent quality and nutrition degradation, reduce microbial contamination, and enhance tenderness.
The first objective of this research was to examine the influence of high-pressure processing and addition of natural antimicrobials …
Sustainability Across The Food System In The Southeastern United States: Mitigating Restaurant Plate Waste And Exploring Peach Orchard Viability Amidst Armillaria Root Rot, Samuel Francis
All Theses
In 2023, 5.6% ($1.5 trillion dollars) of the United States’ Gross Domestic Product was derived from agriculture, food, and related industries. Despite the sector being efficient, challenges still exists. For example, food waste is a problem in the hospitality industry and farmers face challenges related to disease. To ensure the security and efficiency of the food supply, it is in our best interest to make adjustments in these sectors by taking actions such as reducing waste and mitigating food loss associated with disease. I explore two areas of the food supply that can benefit from changes, seeking to mitigate food …
Exploring The Motivations And Determinants Of Farmer’S Market Consumers And Organic Specialty Crop Producers, Jane Arnold
Exploring The Motivations And Determinants Of Farmer’S Market Consumers And Organic Specialty Crop Producers, Jane Arnold
All Theses
This two-chapter thesis evaluates the motivations and determinants of the central figures in farmers’ markets and organic markets. The first chapter explores the rise of farmers’ markets popularity through an in-person survey that was designed and distributed to 274 farmers' market consumers. Logit and ordered logit regressions were used to identify the motivations and characteristics that affect the likelihood of being a frequent farmers’ market customer (visiting 5 times or more per season) and spending over $50. The second chapter investigates the organic markets for cucumber and kale, which are dominant specialty crops on today’s grocery shelves. To identify the …
Role Of The Malate Dehydrogenase-Citrate Synthase Metabolon In Metabolic Flux Regulation, Joy John Omini
Role Of The Malate Dehydrogenase-Citrate Synthase Metabolon In Metabolic Flux Regulation, Joy John Omini
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
The TCA cycle enzymes- malate dehydrogenase (MDH) and citrate synthase (CS)- interact to transfer oxaloacetate from the active site of MDH to the active site of CS, through an electropositive channel. The MDH-CS metabolon is highly conserved across different domains of life, and it has been associated with many advantages. Some of these advantages include protecting oxaloacetate from competing enzymes like aspartate aminotransferase, allowing the thermodynamically unfavorable MDH forward reaction to occur and increasing the local concentration of oxaloacetate within the active site of CS. These advantages and conservativeness of the MDH-CS metabolon indicate that it is highly important to …
Dynamics Of Soybean Seed Protein And Oil Content With Depth In The Canopy, Hafith Furqoni
Dynamics Of Soybean Seed Protein And Oil Content With Depth In The Canopy, Hafith Furqoni
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Understanding the physiological basis of variation in seed composition is critical for optimizing soybean seed composition. Also, studying dry matter accumulation and nitrogen uptake, partitioning, and redistribution in soybeans is crucial due to its direct impact on seed yield levels and overall plant productivity. This study aimed to test the primary proxy influencing seed protein and oil content, which is their accumulation rate determined by the assimilate supply per seed. The second objective was to comprehensively understand soybean dry matter (DM) accumulation and nitrogen (N) uptake, partitioning, and removal patterns within the canopy. Field experiments were conducted using two soybean …
The Effects Of Anchor Scheme On The Central And Peripheral Contributions To Performance Fatigability, Perceived Responses And Sensations, And Psychological Factors Following Sustained, Isometric Forearm Flexion Tasks To Failure, Robert Walker Smith
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
The Effects of Anchor Scheme on the Central and Peripheral Contributions to Performance Fatigability, Perceived Responses and Sensations, and Psychological Factors Following Sustained, Isometric Forearm Flexion Tasks to Failure Robert W. Smith, Ph.D. University of Nebraska, 2024 Advisor: Terry J. Housh This study assessed time to task failure (TTF), performance fatigability (PF), neuromuscular responses, central and peripheral measures of fatigue, and perceived responses including sensations and psychological factors that contributed to task termination during sustained, isometric forearm flexion tasks anchored to ratings of perceived exertion (RPE) and the torque corresponding to RPE. Fifteen men (age = 21.5 ± 2.3 yrs; …
Assessing, Restoring, And Centering Social–Ecological Relationships For Advancing Social–Ecological Resilience In The Northern Great Plains Grasslands, Katia Pilar Carranza Bernal
Assessing, Restoring, And Centering Social–Ecological Relationships For Advancing Social–Ecological Resilience In The Northern Great Plains Grasslands, Katia Pilar Carranza Bernal
School of Natural Resources: Dissertations, Theses, and Student Research
The Northern Great Plains grasslands are social-ecological systems that were shaped by evolutionary and Indigenous social-ecological relationships. European colonization disrupted many of these interactions, including the coupling of fire and grazing, and degraded social-ecological resilience, shifting these grasslands to a new state. For those reasons, my research focused on assessing, restoring, and centering evolutionary and Indigenous social-ecological relationships for advancing social-ecological resilience in the Northern Great Plains grasslands. I first performed a study in the Nebraska Sandhillls assessing the potential of patch-burn grazing to support grassland resilience by comparing its effects to those of rotational grazing. Through vegetation and bird …
Assessment Of The Drivers Of Adoption Of Climate Smart Agriculture Practices Among Field Crop Farmers In Zambia, Faindani Nyirenda
Assessment Of The Drivers Of Adoption Of Climate Smart Agriculture Practices Among Field Crop Farmers In Zambia, Faindani Nyirenda
Graduate Theses and Dissertations
Climate smart agriculture (CSA) practiced has been promoted in Zambia since the 1980s to address the declining crop productivity due to increased occurrence of drought or dry spells caused by climate change. Despite considerable research indicating that CSA practices have many potential benefits such as increased yield and income, the adoption rate in southern Africa is still low especially where farmers have stable off farm income. This might be because most of the research and promotion has been directed to the main staple crop maize and other context specific impacts related to agroecological and socioeconomic heterogeneity. In this study we …
B.R. Wells Arkansas Rice Research Studies 2023, J. Hardke, X. Sha, N. Bateman
B.R. Wells Arkansas Rice Research Studies 2023, J. Hardke, X. Sha, N. Bateman
Arkansas Agricultural Experiment Station Research Series
Arkansas is the leading rice producer in the United States. The state represents 49.0% of total U.S. rice production and 49.6% of the total acres planted to rice in 2023. Rice cultural practices vary across the state and across the U.S. However, these practices are also dynamic and continue to evolve in response to changing political, environmental, and economic times. This survey was initiated in 2002 to monitor and record changes in the way Arkansas rice producers approach their livelihood. The survey was conducted by polling county extension agents in each of the counties in Arkansas that produce rice. Questions …
Cystic Fibrosis Pathogens Persist In The Upper Respiratory Tract Following Initiation Of Elexacaftor/Tezacaftor/Ivacaftor Therapy, Yasmin K. Hilliam, Catherine R. Armbruster, Glenn J. Rapsinski, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Vaughn S. Cooper, Stella E. Lee, Jennifer M. Bomberger
Cystic Fibrosis Pathogens Persist In The Upper Respiratory Tract Following Initiation Of Elexacaftor/Tezacaftor/Ivacaftor Therapy, Yasmin K. Hilliam, Catherine R. Armbruster, Glenn J. Rapsinski, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Vaughn S. Cooper, Stella E. Lee, Jennifer M. Bomberger
Biological Sciences Faculty Research and Publications
Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in CF are associated with disease state and alterations to the bacterial community after ETI initiation may require changes to clinical management regimens. We collected sinus swab samples from the middle meatus in an observational study of 38 adults with CF and chronic rhinosinusitis (CRS) from 2017 to 2021 and captured the initiation of ETI therapy. We performed 16S and custom amplicon sequencing to characterize the sinus microbiota pre- …