Digital Commons Network^™

The Role Of Adhd As A Risk Factor In Alzheimer's Disease, Evelyn Fulmer

The Cardinal Edge

In recent years, the prevalence of attention-deficit/hyperactivity disorder (ADHD) and Alzheimer’s disease (AD) has increased significantly. While these disorders initially seem unrelated, ADHD and AD pose similarities that indicate a more involved relationship between them. To understand this relationship, this review delves into the current research proposing ADHD as a potential risk factor in the development of Alzheimer's disease, examining genetic predispositions, shared risk factors, and affected mechanistic pathways that influence the aging process.

The Effect Of A Virtual Covid-19 Interprofessional Educational Module On Knowledge, Confidence, Attitude, And Practice Among Health And Allied Health Professions Students, Tsu-Yin Wu, Jenni L. Hoffman, Grigoris Argeros, Sarah Lally, Andrea Gossett Zakrajsek, Jillian Graves, Alice Jo Rainville, Olivia Ford, Angela Lukomski, Renuka Roche, John Sonnega, Joan E. Cowdery Phd

Journal of Interprofessional Practice and Collaboration

Purpose: The purpose of this research study was to examine the effect of an innovative, online COVID-19 interprofessional educational module among health and allied health professions students.

Methods: This study utilized a pre- and posttest design with quantitative and qualitative data collected winter 2023 and spring/summer 2023 semesters, and consisted of health and allied health professions students (N=143) from three Midwestern, urban, public universities. Participants completed a pretest, then an IPE module on COVID-19, and a posttest immediately after the educational intervention, and another (the same) posttest one month later. Quantitative and qualitative data were subject to statistical …

Dysfunction Of Polyamine Metabolism In Down Syndrome Related To Cellular Senescence And Β-Amyloid Production, Andres D. Sola

Electronic Theses and Dissertations

Polyamines (PA) are ubiquitous in cells and highly involved in several important cellular functions and thus the dysregulation of their biosynthetic pathway is potentially associated with the progression of age-related diseases like Alzheimer’s’ disease (AD). Though there is research describing how PA content changes in organisms as they age or in those experiencing rapid aging from increased rates of senescence, as in Down syndrome (DS), it is not clear how this connection occurs and whether modulating this pathway may reveal downstream effects on related disease progression. This study examines how the modulation of the PA biosynthetic pathway by inhibition of …

Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss

Theses and Dissertations

In the future, sustainability in the dairy industry will require creative and scale-able solutions for better utilization of the primary solid component in milk: lactose. One promising avenue of “up-cycling” underutilized lactose is converting it to valuable rare sugars. Rare sugars like D-tagatose and D-allulose are increasing in popularity extremely quickly. D-tagatose and D-allulose are hexose sugars, D-allulose being an epimer of D-fructose and D-tagatose an isomer of D-galactose. They have excellent functional properties in food systems with clean sweetness profiles similar to sucrose. Critically, they also have excellent nutritional characteristics, such as low caloric values and low glycemic indices. …

Limosilactobacillus Reuteri Ameliorates Maternal Separation Stress In Newborn Mice And Alters Subsequent Adult Behaviour, Z. M. Saleh, B. Okeugo, V. R. Venna, F. W. Blixt, V. A. Quaicoe, E. S. Park, S. Giorgberidze, Meng Luo, Christopher M. Taylor, J. M. Rhoads, Y. Liu

School of Medicine Faculty Publications

Maternal separation (MS) in mice results in behavioral deficits and gut microbiota dysbiosis that all persist into adulthood. Limosilactobacillus reuteri DSM 17938 modulates gut microbiota, alters systemic metabolites, and facilitates immune regulation. To assess the effect of DSM 17938 on biochemical and behavioural stress-associated changes, newborn mice were exposed to unpredictable MS (MSU) daily from day 7 to day 20 of life, with intragastric administration of DSM 17938 or PBS as control. Body weight, brain levels of cholecystokinin (CCK), glial fibrillary acidic protein (GFAP), corticosterone, and stool microbiota were assessed at day 21. Behaviour tests including Y-maze (YMT), Tail Suspension …

Prospect And Problem Analysis Of Industry Data Application In Livestock And Poultry Breeding, Yiran Chen, Zhuqing Xiong, Jiaogen Zhou, Quan Wang, Jiancheng Shu, Yinfa Yan, Lanlin Yang, Zemeng Feng, Benhai Xiong, Yulong Yin

Bulletin of Chinese Academy of Sciences (Chinese Version)

Livestock and poultry breeding is a pillar industry in China. The massive data in livestock and poultry breeding is a valuable resource. The market-oriented utilization of livestock and poultry breeding data plays an important role in improving industry standards, increasing industry profits, and driving the development of the entire industry chain. Currently, based on the demand for marketization of livestock and poultry breeding data, the application of new generation information technologies such as artificial intelligence and the Internet of Things in the process of livestock and poultry breeding to collect breeding process data, after de-sensitization and de-classification, through cloud computing, …

Phase I Dose Escalation Study Of Io-108, An Anti-Lilrb2 Antibody, In Patients With Advanced Solid Tumors, Matthew H Taylor, Aung Naing, John Powderly, Paul Woodard, Luke Chung, Wen Hong Lin, Hongyu Tian, Nathan Siemers, Hong Xiang, Rong Deng, Kyu Hong, Donna Valencia, Tao Huang, Ying Zhu, X Charlene Liao, Xiao Min Schebye, Manish R Patel

Faculty, Staff and Student Publications

Purpose: In this first-in-human dose escalation study, the safety and efficacy of IO-108, a fully human monoclonal antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2), was investigated in patients with advanced solid tumors as monotherapy and in combination with pembrolizumab, an anti-programmed cell death protein 1 (PD-1) antibody.

Methods: The study included patients with histologically or cytologically confirmed advanced and relapsed solid tumors, with measurable disease by Response Evaluation Criteria In Solid Tumors (RECIST) V.1.1. Patients were treated with escalating doses of IO-108 every 3 weeks (Q3W) as monotherapy and in combination with pembrolizumab. Safety and tolerability were the primary objectives. …

Body Condition Scoring For Sheep, Abigail Johnson, Reganne K. Briggs, Chad Page

All Current Publications

Body condition scoring is a helpful tool for sheep producers to use to evaluate the status of their flock. This fact sheet illustrates how to condition score sheep and the importance of condition scoring on production.

Dehydration And Traumatic Brain Injury: A Pilot Study Of A Translational Rodent Model Of Conditions In Professional Combat Sports, Alexander S. Martinie, Corey Peacock, Chris Algeri, Bill Kochen

Journal for Sports Neuroscience

Traumatic brain injuries are a widespread public health issue, with athletes being at an increased risk of traumatic brain injury, especially in contact sports. Dehydration and rehydration prior to use of a weight drop served as a model for conditions experienced by professional boxers in a rodent model of traumatic brain injury. Following dehydration, rehydration, and traumatic brain injury procedures, subjects’ symptoms were assessed using the novel object recognition task, sucrose preference test, open field maze, and elevated zero maze. There were significant effects of both dehydration and TBI on time to righting, and there was a significant interaction between …

Genome-Wide Association Analysis And Genomic Prediction Of Salt Tolerance Trait In Soybean Germplasm, Rongqing Xu, Qing Yang, Zhi Liu, Xiaolai Shi, Xintong Wu, Yuenhan Chen, Xingyu Du, Qiqi Gao, Di He, Ainong Shi, Peijun Tao, Long Yan

Horticulture Faculty Publications and Presentations

Introduction:

Soybean is an important protein and oil crop, and improving yield has traditionally been a major breeding goal. However, salt stress is an important abiotic factor that can severely impair soybean yield by disrupting metabolic processes, inhibiting photosynthesis, and hindering plant growth, ultimately leading to a decrease in productivity.

Methods:

This study utilized phenotypic and genotypic data from 563 soybean germplasms sourced from over 20 countries. Employing four distinct models—we performed a genome-wide association study (GWAS) using four models, including MLM, MLMM, FarmCPU, and BLINK in GAPIT 3, we conducted a Genome-Wide Association Study (GWAS) to identify single nucleotide …

Impact Of Stolon Removal On Yield And Fruit Quality Of Day-Neutral Fragaria X Ananassa “Cabrillo” Grown In Outdoor Soilless Conditions, Kate Fessler, Emily E. Hoover, Neil O. Anderson

Journal of Extension

Strawberries are among the most consumed fruits in the U.S. and demand for locally grown fruit is high. Although most production in Minnesota is dominated by June-bearers, new techniques for growing day-neutral strawberries are becoming increasingly prevalent. These techniques include in-ground plasticulture and soilless tabletop production, and growers are generally advised to remove stolons (runners) from day-neutral plants. There is relatively little information available to confirm that this practice, and its attendant labor increase, is a necessity in soilless tabletop production. This study’s objective was to determine whether this practice is necessary to maximize yield and fruit quality, using the …

Virtual Culinary Nutrition Education: Youth And Parent/Guardian Acceptability Of The Switch Cooking School, Summer Mcvicker, Laura Paulsen, Anna Mlodzik, Allison Henry, Maren Wolff

Journal of Extension

Face-to-face cooking programs can positively impact food choices, fruit and vegetable intake, and cooking self-efficacy; however, little is known about virtual cooking programs. We studied the perceived acceptability of the virtual SWITCH Cooking School (SCS). Four monthly cooking classes were offered for each participating school. Classes included nutrition education, food safety, and cooking demonstrations. Feedback was collected through post-class surveys and focus groups with parent/guardian and youth participants. Families valued the convenience of the virtual delivery and were interested in participating again. Future considerations for the SCS include incorporating additional variety of culinary skills and modifying registration methods.

Beyond Direct Education And Facilitation: Revisiting The Role Of Extension In Community & Regional Food Systems Development, Catie M. Demets, Lindsey Day Farnsworth

Journal of Extension

The fundamental issues that community and regional food systems aim to address are inherently systems problems, yet many Extension programs continue to focus food system development efforts on activities and actors that directly support the food value chain. While important, the impact of these interventions is limited. Drawing from interviews with directors of four of the nation’s leading Community and Regional Food Systems Extension programs, this article makes a case for rethinking Extension’s role in community and regional food systems development in relationship to key leverage points through a typology of Extension roles and corresponding examples.

Who Cares For The Caregiver? Exploring Extension’S Role In Informal Caregiving Support, Mckenzie R. Tuttle, Erin L. Martinez, Aimee Fox

Journal of Extension

Family caregivers provide invaluable service by taking on the responsibility of caring for older adults in the United States. With a growing aging population, the need for family caregivers and demands on their time and resources will continue to increase. Although a variety of caregiving resources and support services exist, family caregivers often lack the awareness, time, transportation, or financial resources to connect to services. There is a critical need to address the barriers that prevent caregivers from accessing services. In this commentary, we highlight barriers and make recommendations for improving conversations, research, and practice to meet this growing problem.

Can Lower-Body Strength And Power Alleviate Load Carriage Performance Decrements (Tactical Deficit) In Simulated Law Enforcement Job Tasks?, Ashley M. Bloodgood, Joseph Dulla, Megan Thompson, Matthew R. Moreno, Robin (Rob) Marc Orr, J. Jay Dawes, Robert G. Lockie

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1577-1594, 2024. Law enforcement agencies typically have recruits complete fitness assessments without personal protective equipment (PPE). PPE negatively impacts performance. Greater strength and power could alleviate performance decrements due to the extra load, termed the tactical deficit (TD). The purpose of this study was to examine whether lower-body strength or power related to the TD in civilians performing police tasks. Twenty participants (12 men, 8 women) completed baseline tests, including: standing broad jump (SBJ); relative SBJ; absolute and relative isometric leg/back dynamometer (LBD) and one-repetition maximum hexagonal bar deadlift (HBD). In two other sessions, …

Curcumin Reduces Malondialdehyde And Improves Antioxidants In Humans With Diseased Conditions: A Comprehensive Meta-Analysis Of Randomized Controlled Trials, Mohammad Alizadeh, Sorayya Kheirouri

BioMedicine

Objective: This systematic review and meta-analysis was conducted to collate the effects of curcumin on MDA and antioxidant markers in individuals with diseased conditions. In this study the research question was “does curcumin supplementation improves oxidative stress and antioxidant defense enzymes in human subjects compared to a group without curcumin supplementation?

Methods: This research included randomized controlled trials published in English in any year, in which intervention with curcumin was compared to either placebo, or standard of care or no intervention. Pubmed, Embase, Cochrane Central, Scopus and Google Scholar were searched. Meta-analysis was performed using RevMan (version 5.3), with standardized …

Cohort Study Of Microelement Status In “Healthy” Population Of Russian Megapolis, Andrew K. Martusevich, Konstantin A. Karuzin

BioMedicine

The aim of the study was at the cohort assessment of microelement status in large city residents classified as “apparently healthy people”. The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender. A blood sample was taken once from each person to determine concentrations of microelements. The level of peripheral blood microelements were determined by atomic absorption spectrometry using «Shimadzu AA7000» device (Japan). The study of a large population of city residents demonstrated inhomogeneity in their microelement status. Deficit conditions were found …

Awareness On Breast Cancer Screening In Malaysia: A Cross Sectional Study, Mun-Seng Lee, Choiriyatul ‘Azmiyaty Amar Ma’ Ruf, Dayang Puteri Nadhirah Izhar, Sayyida Nafisah Ishak, Wan Syazana Wan Jamaluddin, Syafiqah Nadiah Mohd Ya’Acob, Muhammad Nazrullah Kamaluddin

BioMedicine

Introduction: The increasing rate of breast cancer (BC) incidence in Malaysia hints a lack of awareness among Malaysians. One (1) woman out of nineteen (19) is at risk with BC and almost up to fifty percent (50%) of women diagnosed with BC were reported to be under the age of fifty (50). Our main concern is to study the level of awareness among the women on risk factors, clinical manifestations, diagnosis, preventions and treatments.

Method: A cross-sectional study was conducted exclusively among women in the public with total sample of three hundred and forty six (346), questionnaires were distributed using …

The Effect Of NigellaSativaOil On The Prevention Of Phlebitis Induced By Chemotherapy: A Clinical Trial, Niaz Behnamfar, Zohreh Parsa Yekta, Faraz Mojab, Seyyed Mohammad Kazem Naeini

BioMedicine

Introduction: Phlebitis, that disrupts chemotherapy, is the inflammation of the vein and the most common complication of intravenous injection of chemotherapy drugs.

Aim: the aim was determine the effect of topical application of N.sativaoil on the prevention of phlebitis caused by chemotherapy.

Methods: This single-blind clinical trial was conducted on 60 cancer patients. In the intervention group, five drops of N.sativaoil was applied on the distal area of the catheter, two times per day and every 12 hours from the first day of chemotherapy to the third day; no intervention was conducted for the subjects in the control group.

Results: …

In Vivo Microdialysis And In Vitro Hplc Analysis Of The Impact Of Paeoniflorin On The Monoamine Levels And Their Metabolites In The Rodent Brain, Yuh-Tzy Lin, Wei-Shih Huang, Huei-Yann Tsai, Min-Min Lee, Yuh-Fung Chen

BioMedicine

Background: Paeoniflorin (PF) possesses several effects such as analgesic, the anti-spasmodic effect on smooth muscle. It protects the cardiovascular system and reveals the neuroprotective effect on cerebral ischemia. Monoamine system has been identified to have complex regulatory effects in pain signaling. There are no reports regarding the impact of PF on monoamine levels in the rodent brain by microdialysis. In this study, the effects of PF on monoamines and their metabolites in the rodent brain usingin vivomicrodialysis andin vitrohigh performance liquid chromatography (HPLC) analysis.

Methods: Male S.D. rats were anesthetized, fixed onto the stereotaxic instrument to identify the positions of …

Gynura BicolorAqueous Extract Attenuated H2O2Induced Injury In Pc12 Cells, Ya-Chen Yang, Wen-Tzu Wu, Mei-Chin Mong, Zhi-Hong Wang

BioMedicine

Background: Protective effects ofGynura bicoloraqueous extract (GAE) at three concentrations upon nerve growth factor (NGF) differentiated-PC12 cells against H₂O₂induced injury were examined.

Methods: NGF differentiated-PC12 cells were treated with GAE at 0.25%, 0.5% or 1%. 100 μM H₂O₂was used to treat cells with GAE pre-treatments. After incubating at 37 °C for 12 hr, experimental analyses were processed.

Results: H₂O₂exposure decreased cell viability, increased plasma membrane damage, suppressed Bcl-2 mRNA expression and enhanced Bax mRNA expression. GAE pre-treatments reversed these changes. H₂O₂exposure reduced mitochondrial membrane …

Applying Wcacg Modified Process Is Beneficial On Reduced Door-To-Balloon Time Of Acute Stemi Patients, Qiao-Wen Li, Xiao-Jian Liu, Jin-Hua Li, Guo-Qi Zhang, Su-Min Chen, Chao-Long Huang, Min Qiu, Yue-Liang Li, Peng Duan, Yi-Jiun Weng, Xiao-Yong Zhang, Chih-Yang Huang

BioMedicine

Background: Various systems have employed with the objective to reduce the time from emergency medical services contact to balloon inflammation for ST-elevation myocardial infraction (STEMI) patients. The WCACG message system was used to an alternative communication platform to improve confirmation of the diagnosis and movement to treatment, resulted in shorten the door-to-balloon (D-to-B) time for STEMI patients.

Methods: We collected 366 STEMI patients admitted at the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Department of Cardiology, during the period from June 2013 to October 2015. The patients were divided into two groups one underwent the current GC …

Systematic Review Of Immune Checkpoint Inhibitor-Related Gastrointestinal, Hepatobiliary, And Pancreatic Adverse Events, Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bret Lashner, Bryan Schneider, John A Thompson, Michel Obeid, David P Farris, Yinghong Wang

Faculty, Staff and Student Publications

Gastrointestinal immune-related adverse events (GI irAEs) are common manifestations of immune checkpoint inhibitor (ICI) toxicity. We present a comprehensive systematic review of the incidence, management, and clinical course of irAEs across the entire GI system, including the luminal GI tract, liver, and pancreas. MEDLINE, Embase, Web of Science Core Collection, and Cochrane Library were used to conduct this review. All studies pertaining to GI irAEs were included. Both abstracts and full manuscripts were eligible if they included human subjects and were written in the English language. Articles not available in English, animal studies, or research not specific to GI toxicity …

Oncolytic Virotherapies And Adjuvant Gut Microbiome Therapeutics To Enhance Efficacy Against Malignant Gliomas, Natalie M Meléndez-Vázquez, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most prevalent malignant brain tumor. Current standard-of-care treatments offer limited benefits for patient survival. Virotherapy is emerging as a novel strategy to use oncolytic viruses (OVs) for the treatment of GBM. These engineered and non-engineered viruses infect and lyse cancer cells, causing tumor destruction without harming healthy cells. Recent advances in genetic modifications to OVs have helped improve their targeting capabilities and introduce therapeutic genes, broadening the therapeutic window and minimizing potential side effects. The efficacy of oncolytic virotherapy can be enhanced by combining it with other treatments such as immunotherapy, chemotherapy, or radiation. Recent studies …

Harvesting And Processing Techniques Of Tropical Grass And Legume Seeds For Smallfarmers, Lumyai Kowithayakorn, Chaisang Phaikaew

IGC Proceedings (1977-2023)

For smallfarmers of forage legumes and grasses in Thailand, manual harvesting and cleaning of leguminous seeds have been widely practised because of cheap and available labour. Tropical grasses produce more seeds than can be harvested; hence it is necessary to find means to improve harvesting and processing techniques in order to obtain high standards of both quality and quantity of seed. The main obstacles could be due to prolonged flowering nnd grain filling periods of individual seedheads resulting in the uneven ripening of seeds at harvest. Premature seeds cause low yields and low quality nt harvests in many species. Flowering …

Yield, Composition And In Vitro Digestibility Of Russell Lupin, S M. Kitessa, G D. Hill, A M. Nicol

IGC Proceedings (1977-2023)

Six harvests were made (at 3-weekly intervals) from spring regrowth of Russell lupin (Lupinus polyphyllus x Lupinus arboreus ) to evaluate changes in yield and nutritive value with plant maturity. Dry matter (DM) yield and neutral detergent fibre (NDF) concentration increased from 40 to 160 g/plant and 24 to 46%, respectively, while nitrogen concentration, in vitro cellulase DM and organic matter digestibility decreased from 4.5-2.4%, 77-56% and 81-55%, respectively, as the lupins matured from late vegetative to hard pod stage. Peak digestible DM (DDM) yields of Russell lupins, at about 90 g/plant, occurred at full bloom and dry pod, …

Ruzi Grass (Brachiaria Ruziziensis) Seed Production In North-East Thailand, Chaisang Phaikaew, Chanchai Manidool, Pimpaporn Devahuti

IGC Proceedings (1977-2023)

The recent expansion of beef and dairy production in Thailand has increased demand for pasture seed. Ruzi grass (Brachiaria ruziziensis) seed production has increased from 18 tin 1983 to 466 tin 1991. The; production sites are in the north east, where soils and climate are most suitable for seed production. 60% of all ruzi seed is being produced by smallfarmers; the rest is produced by government stations. Average farmer yield of rilzi is 400 kg • seed/h'a, with each farmer contracted 'to grow 0.32 h�� of ruzi grass, at a guaranteed price of US$2/kg; Abo·ut 2700 farmers are …

Winter Cold Temperate Rangelands: Improvement Strategies For Intensive Rangeland Ecosystems, B E. Allan, D Scott

IGC Proceedings (1977-2023)

Transfer of developed grassland technologies to rangelands is discussed in terms of environmental gradients and the options and constraints they impose. Winier feed limitation can be overcome through conserved feeds and various in situ systems involving special purpose pastures and feed banks. General animal nutrition can be improved through intensive development, low input systems, better control of range utilisation and, where appropriate, correction of mineral deficiencies. The emphasis in seeking quick and easy solutions to rangeland management problems is questioned, A more informed, environmentally sound and sustainable approach to rangeland fanning atlitudes and management is proposed. A stepwise process to …

Hans Holbein's Portrait Of Henry Viii: England's Own Personal Jesus, Amy Pitsor

Best Integrated Writing

Pitsor explores the possibility that Holbein’s late-stage change in the composition of the portrait from a three-quarter view of Henry to a frontal view held a motive to present Henry as the head of the newly established Church of England and as equal to the pope, and possibly to Christ himself.

La Falta De Los Supermercados En El Oeste De Dayton: Cómo Obtienen Los Estudiantes Comida Fresca En Los Desiertos Alimentarios (Un Ensayo Expositivo-Argumentativo, Catherine Iacobacci

Best Integrated Writing

After having learned about how poverty can affect children’s educational outcomes in one of her classes, Iacobacci wanted to learn more about how the issue affected the area where she lived and went to school. What she found out was incredibly shocking, and only furthered the idea that students are struggling with opportunity gaps, not achievement ones. Unfortunately, due to discriminatory loan practices from long ago, children from the 21st century are suffering physically, emotionally, and academically.