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Articles 751 - 780 of 116434
Full-Text Articles in Entire DC Network
Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel
Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel
Turkish Journal of Veterinary & Animal Sciences
The present study aimed to investigate the hematological and biochemical blood parameters, along with selected egg quality traits, of Turkish Sultan chickens. A total of 90 blood samples collected from 60-week-old hens and roosters and 129 eggs collected from 50 hens were analyzed. The findings showed that hematological parameters such as red blood cells (RBC), hemoglobin (HGB), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and heterophil-to-lymphocyte (H/L) ratio, as well as biochemical markers such as aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and uric acid levels, were significantly higher in roosters. The average egg weight, shape …
The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever
The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever
Turkish Journal of Veterinary & Animal Sciences
Ticks are obligate hematophagous ectoparasites that play a major role in the transmission of pathogens affecting both animals and humans. Investigations into tick biology, pathogen transmission, and the development of effective control strategies have traditionally depended on the extensive use of laboratory animals. Consequently, the development of reliable in vitro feeding systems is a valuable alternative approach with the potential to reduce animal use in tick research. In the present study, a previously described silicone membrane artificial feeding system was modified and applied for the in vitro feeding of Hyalomma marginatum (Koch, 1844). Feeding units were prepared using bovine blood …
Immunohistochemical Expression Of Lgr5 In The Bovine Ovary, Oviduct, And Uterus, Aytül Kürüm, Yasi̇n Özkabadayi, Hakan Kocamiş, Mustafa Türk, Si̇yami̇ Karahan
Immunohistochemical Expression Of Lgr5 In The Bovine Ovary, Oviduct, And Uterus, Aytül Kürüm, Yasi̇n Özkabadayi, Hakan Kocamiş, Mustafa Türk, Si̇yami̇ Karahan
Turkish Journal of Veterinary & Animal Sciences
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has recently been considered as a stem cell marker seen especially in mitotically active tissues. The aim of the present study was to investigate the immunohistochemical expression of LGR5 in the bovine reproductive tract, which is regularly renewed in response to hormonal changes throughout the estrous cycle. The oviduct (ampulla, isthmus, and fimbria), uterus, and ovary tissue samples were collected from 12 cows at a local slaughterhouse. The samples were further identified as follicular (n = 6) or luteal (n = 6), subjected to routine histological procedures, and processed for immunohistochemical expression of …
Origins Of Mitochondrial Diversity In Turkish Sheep Breeds: Anatolia As A Contact Zone Or Refugial Center?, Nezi̇h Ata, İbrahi̇m Cemal
Origins Of Mitochondrial Diversity In Turkish Sheep Breeds: Anatolia As A Contact Zone Or Refugial Center?, Nezi̇h Ata, İbrahi̇m Cemal
Turkish Journal of Veterinary & Animal Sciences
Advances in molecular genetics, especially the integration of mitochondrial DNA (mtDNA) analyses, have significantly transformed our understanding of the origins, geographical centers, and dispersal dynamics of domestication, a field traditionally based on archaeological and morphological evidence. In this study, the mtDNA control-region sequences of 296 individuals from 15 native Turkish sheep breeds were analyzed to clarify their maternal genetic diversity and evolutionary origins. Sequencing of a 531-bp D-loop fragment revealed 53 polymorphic sites and 78 distinct haplotypes, indicating substantial haplotypic diversity (Hd = 0.918) and nucleotide diversity (π = 0.01391) within these populations. All five major ovine mitochondrial haplogroups (A, …
Diet And Microbiome Shape Small-Molecule Cytokinin Pools In Mammals, Eman M. Othman, Elena Bencurova, Pamela Ferretti, Peer Bork, Alvaro Rodriguez Del Rio, Jaime Huerta-Cepas, Ignazio Caruana, Rania Abdel-Latif, Aman Akash, Alfonso Albacete, Feras Lafi, Thomas Dandekar, Muhammad Naseem
Diet And Microbiome Shape Small-Molecule Cytokinin Pools In Mammals, Eman M. Othman, Elena Bencurova, Pamela Ferretti, Peer Bork, Alvaro Rodriguez Del Rio, Jaime Huerta-Cepas, Ignazio Caruana, Rania Abdel-Latif, Aman Akash, Alfonso Albacete, Feras Lafi, Thomas Dandekar, Muhammad Naseem
All Works
Cytokinins (CKs) are adenine-derived metabolites traditionally characterized as plant hormones, yet their origin, distribution, and functions in mammalian systems remain largely undefined. Using integrated metabolomics, microbiome, and metagenomics approaches, we provide a systematic characterization of CK occurrence and potential sources in mammals. Serum profiling across five animal species revealed consistent detection of multiple CK derivatives, with concentrations markedly lower than in plant tissue. The CK storage form, zeatin-O-glucoside, predominated in mammalian sera, followed by trans-zeatin and kinetin, indicating a CK composition distinct from that in plants. Species-specific differences, such as reduced trans-zeatin in mice and lower kinetin in humans, further …
1 Billion Birds Lost: Mechanisms Of Window Collisions And Possible Mitigation Strategies At Lawrence University, Shoshana Schmit
1 Billion Birds Lost: Mechanisms Of Window Collisions And Possible Mitigation Strategies At Lawrence University, Shoshana Schmit
Lawrence University Honors Projects
Windows are currently the largest killer of birds on the planet, with an estimated 1 billion birds dying from collisions annually. If birds that hit windows do not die on impact, they may either die elsewhere shortly afterwards, resulting in the number of carcasses at collision sites being a conservative estimate of the actual number of fatalities. During the day, proximity to foraging sites and reflectivity play crucial roles in the danger of windows, and during the night, artificial illumination emitting from windows disorients and inhibits navigational cues. To explore this topic on campus, I documented bird collisions at Lawrence …
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Bap1 Loss Links Myc Activation, Stress Response Vulnerability, And Disease Progression In Kidney Cancer, Ilya Strunilin
Arts & Sciences Graduate Student Theses and Dissertations
BAP1, a chromatin modifier, is a frequently mutated tumor suppressor in clear cell renal cell carcinoma (ccRCC). Mutations in BAP1 are associated with a more aggressive and lethal disease. However, the downstream mediators of BAP1 loss in ccRCC oncogenesis are not well understood. To better understand mechanisms of BAP1-mediated tumor suppression, I have extensively characterized the very early transcriptional mediators of BAP1 loss in a postnatal kidney-specific genetic knockout model. Because VHL loss is the initiating event in ccRCC, we modeled Bap1 loss in a Vhl-deficient background. I have found that Vhl/Bap1 double-knockout cells of PT segment S2 strongly activate …
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan
Arts & Sciences Graduate Student Theses and Dissertations
High grade serous ovarian carcinoma (HGSOC) is an aggressive, highly lethal subtype of ovarian cancer. These cancers are typically diagnosed in later stages and are associated with poor patient prognosis. Additionally, HGSOC is characterized by numerous markers of genomic instability and defects in DNA repair pathways, vulnerabilities which have been exploited by the advancement of chemotherapy. Despite these clinical advancements, HGSOC remains a significant therapeutic challenge due to emergence of chemoresistance and limited targeted treatment options. Taken together, these factors highlight an ongoing need to study the development of HGSOC and its progression to identify more effective treatment opportunities. We …
Structure-Based Discovery Of Malate Dehydrogenase Inhibitors With Efficacy Against C. Parvum Oocysts, Ankita Bharatbhai Kheni
Structure-Based Discovery Of Malate Dehydrogenase Inhibitors With Efficacy Against C. Parvum Oocysts, Ankita Bharatbhai Kheni
Biochemistry and Molecular Biology
Cryptosporidium parvum, the etiological agent of Cryptosporidiosis (diarrheal illness) represents a significant global health burden, particularly affecting immunodeficient and pediatric populations. Since the parasite has a highly reduced mitochondrion and relies on glycolysis, enzymes such as C. parvum malate dehydrogenase (CpMDH), which are believed to be indispensable for parasite viability due to their pivotal roles in NAD⁺ regeneration and redox balance, remain largely unexplored as therapeutic targets. The present study employed a multifaceted experimental and computational strategy to evaluate the inhibitory activity of two lead-like and drug-like small molecules, referred to as compound 1.8 and compound 1.5, against the cofactor …
Metal Oxide Nanoparticle‑Integrated Phema Hydrogels: Morphology, Chemical Properties, And Biological Interaction, Venkateswar Rao, Collin Cox, Brandon Clark, Arushi Rai, Erick S. Vasquez-Guardado, Madhuri Kango-Singh, Soubantika Palchoudhury
Metal Oxide Nanoparticle‑Integrated Phema Hydrogels: Morphology, Chemical Properties, And Biological Interaction, Venkateswar Rao, Collin Cox, Brandon Clark, Arushi Rai, Erick S. Vasquez-Guardado, Madhuri Kango-Singh, Soubantika Palchoudhury
Chemical and Materials Engineering Faculty Publications
Hydrogels offer attractive matrices for incorporating inorganic metal oxide nanoparticles (NPs) to generate multifunctional hybrid materials, but challenges remain in scalable synthesis and correlating their properties to bio-interaction. Therefore, we report the synthesis and characterization of poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels, and pHEMA hydrogels encapsulating iron oxide or zinc oxide NPs, using a modified free-radical polymerization. Dose-dependent survivorship studies on Drosophila melanogaster revealed that both NP-embedded hydrogels are tolerated over a wide dose range (e.g., 50–200 mg), although ZnO NP-gels exhibit lower survivorship at some concentrations due to their inherent composition and a wider size distribution of iron oxide NPs.
Determinants Of Corporal Punishment And Severe Physical Punishment In Egypt: A Mixed-Methods Analysis For Child Protection Policy, Marwa Moustafa Nassef
Determinants Of Corporal Punishment And Severe Physical Punishment In Egypt: A Mixed-Methods Analysis For Child Protection Policy, Marwa Moustafa Nassef
Theses and Dissertations
Corporal punishment (CP) and severe physical punishment (SPP) remain a major public health, child rights, and child protection policy concern. In Egypt, despite legislative reforms, survey-weighted analysis of the 2021 Egypt Family Health Survey (EFHS) 2021 (CAPMAS, 2022) reveals prevalence rates of 60.5% for CP and 27.4% for SPP among children aged 1–14 (author’s calculations using EFHS-2021, n=7623), yet evidence distinguishing the determinants of routine corporal punishment from escalation to severe physical punishment remains limited in low- and middle-income contexts. Guided by Bronfenbrenner’s ecological framework, this mixed-methods study identifies key drivers of CP and its escalation to SPP among Egyptian …
Mapping The Neuroexposome: Integrative Analysis Of Dementia Risk Factors Through Multi-Omics And Environmental Profiling In The Egyptian Population., Mai Ahmed Saadzaghloul Othman
Mapping The Neuroexposome: Integrative Analysis Of Dementia Risk Factors Through Multi-Omics And Environmental Profiling In The Egyptian Population., Mai Ahmed Saadzaghloul Othman
Theses and Dissertations
Background: Dementia represents one of the most pressing public health challenges of the twenty-first century, with the global burden projected to reach 153 million cases by 2050. Egypt, as the most populous Arab nation, faces a corresponding rise in age-related diseases, yet comprehensive data from low- and middle-income countries remain severely limited. The neuroexposome framework, integrating genetic susceptibility, environmental exposures, and metabolic alterations, offers a powerful strategy to characterize the complex interplay between internal and external risk factors for Alzheimer's disease (AD) and Alzheimer's disease Related Dementias (ADRD).
Objectives: This thesis aimed to: (1) examine the distribution of APOE alleles …
The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay
The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay
University Honors Theses
This literature review examines how diet, stress, environmental exposure, and food accessibility may influence college students' mental health and academic performance through the gut microbiome and the Gut-Brain Axis (GBA). Current microbiome research often focuses on early childhood development, clinical disease populations, or older adults, while overlooking college-age students who experience significant social, environmental, and biological transitions. College students frequently face food insecurity, irregular eating patterns, chronic stress, inconsistent sleep schedules, and reduced access to nutrient-dense foods, all of which may influence microbial diversity and overall gut health.
This thesis explores how modern campus environments and lifestyle factors may contribute …
Colostrum And Rethinking Passive Transfer In Dairy Calves, Drew Swartz, Kalen Taylor, Maggi Mathews
Colostrum And Rethinking Passive Transfer In Dairy Calves, Drew Swartz, Kalen Taylor, Maggi Mathews
All Current Publications
This fact sheet provides an overview of colostrum and passive transfer in dairy calves, with information applicable to producers, consultants, educators, and students.
Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
All Current Publications
This fact sheet provides a technical overview of colostrum management in dairy calves, including evaluation methods and evidence-based recommendations for consultants, educators, and students.
Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone
Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone
Euscorpius
Scorpions employ their stinging mechanism both for defense and predation, and being ectothermic, temperature influences their physiology and behavior. As such, we hypothesized that temperature both affects defensive stinging and prey-capture behavior in scorpions. We tested the effects of body temperature on these behaviors in the desert hairy scorpion, Hadrurus obscurus Williams, 1970. In the first experiment, scorpions were placed in temperature-controlled chambers with either high (26-28°C) or low (21- 22°C) temperatures and probed to elicit a defensive sting. We recorded the reaction time and the number of probes needed to elicit a sting. In the second experiment, we observed …
Effect Of Level Of Nitrogen Fertilization Of Kentucky 31 Tall Fescue (Festuca Arundinacea Schreb.) On Brood-Cow Health, J A. Stuedemann, S R. Wilinson, H Ciordia, A B. Caudle
Effect Of Level Of Nitrogen Fertilization Of Kentucky 31 Tall Fescue (Festuca Arundinacea Schreb.) On Brood-Cow Health, J A. Stuedemann, S R. Wilinson, H Ciordia, A B. Caudle
IGC Proceedings (1977-2023)
Studies were conducted to assess the long-term effects of nitrogen (N) fertilization of tall fescue on cow-calf performance and health problems, including grass tetany, fat necrosis, gastrointestinal parasitism, and nitrate poisoning. Kentucky 31 tall fescue pastures fertilized at three levels of N were grazed with Angus cows at 0.4 ha/cow on a year-round basis. Fertilization levels included high N (667 and 0 kg N/ha/yr from broiler litter in 1968-1974 and 1975-1977, respectively); moderate N (134 and 224 kg N/ha/yr from ammonium nitrate [NH4N03] in 1969 and 1970-1977, respectively); and low N (84 and 74 kg N/ha/yr from NH4N03 in 1972 …
Long-Term Feeding Of Corn Silage As The Sole Forage In Diets Of Lactating Dairy Cows, C H. Noller, N J. Moeller, C L. Rhykerd
Long-Term Feeding Of Corn Silage As The Sole Forage In Diets Of Lactating Dairy Cows, C H. Noller, N J. Moeller, C L. Rhykerd
IGC Proceedings (1977-2023)
The long-term feeding of corn silage as the sole forage to lactating dairy cows has had only limited success due to problems with production, reproduction, and health after one lactation. Consequently, a long-term study was begun in August 1975 with two groups of 19 cows, 15 2-year-old heifers, and 4 3-year-old cows assigned at random to each group as they calved. One group was fed a diet with corn silage as the sole forage and the other group a diet with a 50: 50 ratio of forage as corn silage (CS) and low-moisture alfalfa-orchardgrass ( AO) silage. Both rations contained …
High Mobility Group Motif Proteins’ Role In Fibrosis, Inflammation, And Vascular Injury In Systemic Sclerosis, Fabian A. Mendoza, Sonsoles Piera-Velazquez, Sergio A. Jimenez
High Mobility Group Motif Proteins’ Role In Fibrosis, Inflammation, And Vascular Injury In Systemic Sclerosis, Fabian A. Mendoza, Sonsoles Piera-Velazquez, Sergio A. Jimenez
Jefferson Institute of Molecular Medicine Papers and Presentations
Systemic Sclerosis (SSc) is an idiopathic systemic autoimmune disease characterized by progressive cutaneous and systemic fibrosis, severe vasculopathy, and multiple humoral and cellular immunological alterations. The pathogenesis of SSc is highly complex and remains incompletely elucidated. The fibrotic process is a crucial component of SSc and is responsible for organ failure and high mortality. Although an increasing understanding of the fibrotic process has enabled the clinical development of antifibrotic therapeutic agents, these agents have limited clinical efficacy. Recently, the potential role of a group of transcription factors containing a High Mobility Group (HMG) motif, in the development and pathological manifestations …
Lesson 1. Makhózula Etáŋhaŋ Wiyútapi Ke: Tomato Journey From Tiny Seed To My Plate, Rachel Pastrana, Madhav P. Nepal
Lesson 1. Makhózula Etáŋhaŋ Wiyútapi Ke: Tomato Journey From Tiny Seed To My Plate, Rachel Pastrana, Madhav P. Nepal
iLEARN Teaching Resources
In this engaging kindergarten food systems lesson, students become “Plant Parents” as they follow the remarkable journey of a tomato from a tiny seed to food on their plate. Through storytelling, observation, movement, and hands-on plant care, students explore how sunlight, water, and soil work together to support plant growth. Using the Lakota concepts of Makhózula (Abundant Land), Wopila (Gratitude), and Mitákuye Oyás’iŋ (We Are All Related), students learn that food is a gift made possible by the cooperation of people, plants, animals, and natural resources. Students observe and care for tomato seedlings, participate in outdoor exploration activities, and create …
Lesson 2. The Soil Doctors: Healthy Vs. Thirsty Soil Detectives, Rachel Pastrana, Madhav P. Nepal
Lesson 2. The Soil Doctors: Healthy Vs. Thirsty Soil Detectives, Rachel Pastrana, Madhav P. Nepal
iLEARN Teaching Resources
In this lesson, Kindergarten students in Norris, South Dakota, become "Soil Detectives" to investigate the health of Maka (the Earth). By using their hands to touch, squeeze, and compare local schoolyard soil, students learn to identify Maka Wasté (Healthy Soil) and Maka Puza (Thirsty Soil). This lesson utilizes communal storytelling and Lakota terminology to ground scientific inquiry in local Indigenous knowledge and South Dakota land history. Students apply Regenerative Agriculture principles by providing a "cure" protecting the soil with a natural blanket—and conclude with a Wóglaka (Reflection Circle) to share their experiences as young stewards of the land.
Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave
Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave
Research outputs 2022 to 2026
Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations. Ultrasound-assisted aqueous extraction was applied to Lion’s mane (Hericium erinaceus), and the proteins were fractionated by molecular weight (≥30 kDa, 10–30 kDa, 3–10 kDa). Proteomic profiling using data-dependent (DDA) and data-independent (DIA) mass spectrometry identified 1500 and 1702 proteins, respectively (1% global FDR). Ultrasonication induced surface irregularity and a less compact, heterogeneous microstructure. Topology predictions showed higher proportions of transmembrane and secretory proteins in ultrasonicated fractions. Extraction preserved protein integrity (82% molecular-weight retention, 97% tryptic …
Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed
Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed
All Peer-Reviewed Publications
Abstract – Bactrocera dorsalis is a major horticultural pest. Biocontrol using parasitoids, such as Fopius arisanus, is a sustainable tool for managing this pest. However, the mechanisms enabling the successful parasitism of B. dorsalis are poorly understood. Using transcriptomic profiling, cellular bioassays, and targeted metabolite analyses, we investigated how F. arisanus modulates the immunity and metabolic activity of B. dorsalis to achieve a high parasitism rate. Our results revealed a weak and late encapsulation response of B. dorsalis towards F. arisanus. Additionally, parasitism reduced the number of circulating haemocytes by 35%, lowered constitutive granulocyte counts and inhibited phenoloxidase activity in …
Neuroanatomical And Histological Insights Into Central Nervous System Abnormalities Of A 3-Year-Old With Progressive Encephalopathy, Lennox-Gastaut Syndrome, Micrencephaly, And Infantile Spasms, Haley Nation, Omid B. Rahimi, Rachel Morgan-Armbruster, Andrea R. Gilbert
Neuroanatomical And Histological Insights Into Central Nervous System Abnormalities Of A 3-Year-Old With Progressive Encephalopathy, Lennox-Gastaut Syndrome, Micrencephaly, And Infantile Spasms, Haley Nation, Omid B. Rahimi, Rachel Morgan-Armbruster, Andrea R. Gilbert
The Journal of Integrative Physiology
Introduction: This case study presents a comprehensive neuroanatomical and histological analysis of the central nervous system from a 3-year-old donor with a rare complex neurological condition characterized by progressive encephalopathy, Lennox-Gastaut syndrome, micrencephaly, and infantile spasms. Method: This analysis was conducted using a combination of detailed gross dissection and histological examination to assess structural and neuronal abnormalities across multiple brain and spinal cord regions. External and internal analysis of the central nervous system revealed profound developmental and atrophic changes across various brain structures, including absent central sulci, abnormal gyration patterns, and severe cerebellar and cerebral atrophy. Key Findings: Key findings …
Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han
Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent aggrecan under both physiological and inflammatory conditions, without affecting its preferential localization to the pericellular matrix. Conversely, supplementation with exogenous decorin mitigates inflammation-induced loss of nascent aggrecan, supporting its potential as a therapeutic target. At the molecular level, decorin exhibits strong binding affinity for aggrecan, and …
Impact Of Dolutegravir-Based Regimens On Patient Satisfaction And Quality Of Life Among People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Christabel Ogechukwu Okoye, Ruth Jeminiwa, Ifeanyi Kanayo Ifeorah, Lotanna Ezeja, Yusuf Dauran, Sahabi Musa, Silas Usen Joel, Abdurrahman Murtala Bello, Amauche Pearl Ngige, Gabriel Ezenri, Abdulmuminu Isah, Ifunanya Ikhile, Blessing Onyinye Ukoha-Kalu
Impact Of Dolutegravir-Based Regimens On Patient Satisfaction And Quality Of Life Among People Living With Hiv: A Systematic Review And Meta-Analysis, Mustapha Muhammed Abubakar, Christabel Ogechukwu Okoye, Ruth Jeminiwa, Ifeanyi Kanayo Ifeorah, Lotanna Ezeja, Yusuf Dauran, Sahabi Musa, Silas Usen Joel, Abdurrahman Murtala Bello, Amauche Pearl Ngige, Gabriel Ezenri, Abdulmuminu Isah, Ifunanya Ikhile, Blessing Onyinye Ukoha-Kalu
College of Pharmacy Faculty Papers
Background: Despite the global scale up of dolutegravir (DTG)-based regimens as the preferred first-line therapy for persons living with HIV (PLHIV), no comprehensive evidence exists on its effect on patient-reported outcomes such as Quality of Life (QoL) and patient satisfaction (PS). We conducted a systematic review and meta-analysis to provide the first comprehensive quantitative synthesis of the effect of DTG-based regimens on QoL and PS among PLHIV.
Method: We conducted literature search on PubMed, Scopus, Embase and Cochrane Library databases for peer-reviewed, primary studies published from January 2015 to January 2025. Studies using validated tools to evaluate QoL and PS …
Gene × Sex Interactions On Cognition In The Philadelphia Neurodevelopmental Cohort, Josephine Mollon, Emma M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, Elise B. Robinson, Armin Raznahan, Raquel E. Gur, John Blangero, Laura Almasy, David C. Glahn
Gene × Sex Interactions On Cognition In The Philadelphia Neurodevelopmental Cohort, Josephine Mollon, Emma M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, Elise B. Robinson, Armin Raznahan, Raquel E. Gur, John Blangero, Laura Almasy, David C. Glahn
School of Medicine Publications
Background: Small differences between females and males in cognitive abilities have been consistently reported, but the factors underlying these sex differences remain unclear. Social and cultural factors are thought to play a key role, but studies on this topic have been inconclusive. Examination of genetic factors may shed some light on the mechanisms underlying cognitive sex differences.
Methods: Using data from the Philadelphia Neurodevelopmental Cohort, a large, general population sample of individuals aged 8 to 21 years old (N = 4,694), we tested for sex differences in the genetic factors (i.e., Gene × Sex interactions) underlying cognitive ability. Participants completed …
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Journal for Sports Neuroscience
Abstract
Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.
Methods: A real-world clinical pilot …
Scientific Note: Here The Whole Time: A Revised Understanding Of White Alumroot (Heuchera Alba, Saxifragaceae) In The Susquehanna River Valley., Anais Barnes, Madeline Wickers, Scott Schuette, Tanisha M. Williams, Ryan Folk, Christopher T. Martine
Scientific Note: Here The Whole Time: A Revised Understanding Of White Alumroot (Heuchera Alba, Saxifragaceae) In The Susquehanna River Valley., Anais Barnes, Madeline Wickers, Scott Schuette, Tanisha M. Williams, Ryan Folk, Christopher T. Martine
Faculty Journal Articles
Heuchera alba and H. pubescens (Saxifragaceae) are closely related species of alumroot endemic to the Appalachian region of eastern North America that can be difficult to distinguish morphologically. Heuchera pubescens has been understood to occupy a range from Kentucky to Pennsylvania, with the distribution of H. alba restricted to Virginia and West Virginia—plus a recently-recorded extension into Pennsylvania discovered with the help of social media. The uncovering of H. alba in Pennsylvania has challenged historical perceptions of Heuchera distributions in the state, particularly as this relates to the current concept of H. pubescens which may be in need of revision. …
The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang
The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang
iLEARN Teaching Resources
In this lesson, students will begin a week-long unit on soil health that is connected to the chapter The Three Sisters from the book Braiding Sweetgrass by Robin Wall Kimmerer. Students will begin the week by reading the chapter and answering discussion questions, and each subsequent day will build on this introduction with project-based learning activities. This module is designed to bridge traditional Indigenous knowledge with primary scientific inquiry, allowing students to explore soil nutrients, polycultures, and agricultural health in a way they can apply to their own lives and local food sovereignty efforts on the Rosebud Reservation.