Digital Commons Network^™

Investigating The Neuroprotective Effects Of Cannabinoids And Insulin-Like Growth Factors On Glia With Induced Inflammation, Caleb Bloodworth

Honors Theses

Chronic inflammation is a driver of numerous neurodegenerative diseases that reduce quality of life for affected individuals. Non-psychoactive cannabinoids have begun to gain more interest in the world of anti-inflammatory medicine for chronically ill patients. Along with these cannabinoids, insulin-like growth factor-1 has been examined for its association with downregulation of inflammation. Our research aimed to investigate how neuroglia are affected by treatment with cannabinoids or IGF-1 in the face of inflammation from HIV-1 protein, Tat, or lipopolysaccharide (LPS). Preliminary studies in our laboratory showed that neither cannabinoids or IGF-1 treatment altered astrocyte morphology or overall astrocyte viability under baseline …

A Preliminary Report: The Hippocampus And Surrounding Temporal Cortex Of Patients With Schizophrenia Have Impaired Blood-Brain Barrier, Eric L. Goldwaser, Randel L. Swanson, Edgardo J. Arroyo, Venkat Venkataraman, Mary C. Kosciuk, Robert G. Nagele, L. Elliot Hong, Nimish K. Acharya

Rowan-Virtua Research Day

Schizophrenia (SZ) is one of the most severe forms of mental illness, yet mechanisms remain unclear. A widely established brain finding in SZ is hippocampal atrophy, and a coherent explanation similarly is lacking. Epidemiological evidence suggests increased cerebrovascular and cardiovascular complications in SZ independent of lifestyle and medication, pointing to disease-specific pathology. Endothelial cell contributions to blood-brain barrier (BBB) compromise may influence neurovascular unit and peripheral vascular function, and we hypothesize that downstream functional and structural abnormalities may be explained by impaired BBB.

Effects Of Exercise On Parkinson's Symptom Relief, Brooke Burnett

The Eleanor Mann School of Nursing Undergraduate Honors Theses

In this review of twenty research articles, the effects of moderate exercise therapy on the symptoms of Parkinson’s Disease will be explored. Appropriate literature was located using the research question, “In older adults with a Parkinson’s Disease Diagnosis, how does moderate exercise influence the symptoms of this disease?” Twenty peer-reviewed research articles were examined for the impact of different forms of exercise on various symptoms associated with Parkinson’s. Nineteen of the articles reviewed provide substantial evidence in support of exercise therapy as a treatment option for people with Parkinson’s, and one of the articles found inconclusive evidence neither in support …

Growth Differentiation Factor 5 Is A Paracrine Regulator Of Sarcopenic Obesity, Landen W. Saling

Graduate Theses and Dissertations

Sarcopenic obesity attributes to skeletal muscle loss more than sarcopenia and obesity alone. Individuals with SO suffer from the comorbidity of excess body fat and concurrent muscle mass loss due to aging. Growth differentiation factors (Gdfs) have never been recognized as playing a role in skeletal muscle maintenance in those with SO. Specifically, Gdf5, has been recognized as playing a part in Bone Morphogenic Protein signaling to activate protein synthesis and deactivate protein degradation via SMAD 1/5/8 and SMAD 4 complex. Using RNA sequencing, Gdf5 was identified as being significantly upregulated in SO mice. Purpose: To determine the cellular role …

Skeletal Muscle Mass Recovery Early After Left Ventricular Assist Device Implantation In Patients With Advanced Systolic Heart Failure, Amanda R Vest, William W Wong, Joronia Chery, Alex Coston, Laura Telfer, Matthew Lawrence, Didjana Celkupa, Michael S Kiernan, Gregory Couper, Masashi Kawabori, Edward Saltzman

Children’s Nutrition Research Center Staff Publications

Background: Patients with advanced systolic heart failure are at risk of unintentional weight loss and muscle wasting. It has been observed that left ventricular assist device (LVAD) recipients gain weight after device implantation, although it is unknown whether this represents skeletal muscle mass gains. We aimed to determine whether skeletal muscle mass increases early during LVAD support.

Methods: We prospectively recruited 30 adults with systolic heart failure ±21 days from LVAD implantation. Participants underwent whole-body dual X-ray absorptiometry to measure fat free mass, appendicular lean mass (ALM, lean mass in the arms and legs) and fat mass. Dual X-ray absorptiometry …

An Assessment Evaluating The Possible Participation Of A Virtual Nutrition Education Program For Older Adults, Ashlyn Cobble

Undergraduate Honors Theses

The importance of proper nutrition education among older adults is crucial in promoting overall physical health and management of chronic health conditions. However, access to such education has been limited, especially during the COVID-19 pandemic. With the current boom in social media popularity, as well as virtual communication portals such as Zoom, the question must be asked if nutrition education could be effectively implemented for the use of older adults through these electronic channels. The study design for this particular research was a cross sectional survey to inform development of an online nutrition education program for older adults in Northeast …

Relationship Of Eccentric Strength And Forward Perturbation Restabilization After Foot Contact, Leandra K. Ashworth

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Background: Forward falls are the most common fall direction and pose safety concerns for adults. To prevent forward falls, compensatory steps, and change-in-support reactions (e.g., foot contact) are critical for restabilizing center of mass after unpredictable, balance disturbances. Multi-joint, lower limb eccentric and isometric strength may provide additional insight on foot contact responses after a forward, temporally unpredictable perturbation. Multi-joint, eccentric muscular contractions have been found to result in significant neuromuscular adaptations (e.g., hypertrophy and muscular strength) and have higher retention capabilities than concentric contractions. Due to the importance of muscular strength in balance recovery, eccentric muscular strength could provide …

The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie

Graduate Theses and Dissertations

Obesity in the United States continues to increase, and effective, long-term weight loss strategies are limited. Time restricted feeding (TRF) is a dietary intervention that has potential to serve as an effective long-term weight loss strategy, however more data is needed to establish the effectiveness of a TRF eating pattern on obesity and its related health outcomes. To our knowledge, manipulation of macronutrient composition during TRF intervention and the effect of TRF on sleep and mood have not been studied. Therefore, the objective of this study was to determine the effect of protein supplementation during TRF on mood, sleep, and …

The Effects Of A Telehealth Exercise Intervention On Balance In Adults With Down Syndrome, Mark Barton, Kristina Guerrero, Andrew Martinez, Alexandria Umagat

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: People with Down syndrome (Ds) often present with balance deficits, which compromise their safety during daily activity. While evidence shows that exercise can improve balance in the Ds population, it is unclear if a telehealth method will elicit similar benefits. We aimed to examine the effects of a virtual exercise program on balance in adults with Ds.

Methods: Twenty participants completed a 12-week telehealth exercise program based on the Mann Method. Balance testing took place before and after the intervention, which included: Timed Up and Go (TUG), Modified Clinical Test of Sensory Interaction in Balance (MCTSIB), Frailty and Injuries: …

The Associations Of Cardiovascular Disease, Physical Activity Intensities, And Measures Of Obesity On Static Balance In Middle-Aged And Older Adults, Hannah Martha Twiddy

Human Movement Studies & Special Education Theses & Dissertations

The burden of falls is widely known in older adults, though less research has targeted middle-aged adults (40-64 years of age), particularly at the population level. The purpose of this dissertation was to explore the roles of cardiovascular disease, physical activity (PA) intensity, and body anthropometrics on balance among middle-aged adults. Study 1 sought to determine if balance was impaired in middle-aged adults with poor ankle-brachial pressure index (ABPI), a marker of cardiovascular disease. Study 2 determined the associations between PA intensity with odds of having good static balance. Study 3 explored how strongly a variety of anthropometric measures, including …

The Relationship Between Circadian Rhythms And Neurodegenerative Disease, Christopher Simpson

Honors Projects

Neurodegenerative disease is a pervasive and insidious disease affecting a large proportion of the elderly population. Leading to the degeneration of neural tissue throughout the nervous system, it is a slow and progressive disorder. Because of its nature, it is possible that it has a connection to circadian rhythms. Circadian rhythms are the endogenous approximately 24-hour rhythms of the body commonly associated with the sleep-wake cycle, but they account for much more. This review aims to ascertain the relationship between the two by covering several facets of research pursued in the past five years. Beginning with establishing a basic understanding …

The Effect Of Estrogen On Gdnf Production Of Skeletal Muscle In Vitro, Hope Welter

Honors Theses

As life expectancy continues to rise, the number of people over age 65 in the U.S. is increasing. An aging population brings with it impacts on the national health system and associated economic expenditures. As individuals age, the skeletomuscular system suffers reduced function due to disease or conditions such as sarcopenia. Sarcopenia is characterized by muscular atrophy resulting from reduced muscle innervation. Exercise has been linked to prevention of sarcopenia, a suspected result of increased production of glial cell line-derived neurotrophic factor (GDNF). GDNF promotes neuronal survival, regeneration, and the formation of neuromuscular junctions. Therefore, treatments like exercise that increase …

Literature Review On Outer Hair Cell Regeneration And Potential Hearing Restoration, Serena Karlov

Honors Theses

The cochlea is the portion of the inner ear responsible for hearing, containing both the organ of Corti and auditory hair cells. Sound wave vibrations mechanically bend the stereocilia on the three rows of outer hair cells and one row of inner hair cells. These hair cells transduce this mechanical energy into electrical impulses that are relayed from the auditory nerve to the brain, where sounds are processed. In this review I provide an overview of inner ear anatomy, ear physiology, and auditory transduction. I then move on to specifically focus on the importance of outer hair cells, their regeneration, …

Metabolism, Cognition, And Male Coloration In Eastern Mosquitofish, Katelyn Ashleigh Giltner

Honors Capstone Projects and Theses

No abstract provided.

Evaluation Of Nutrition Intervention In The Senior Population, Stephanie K. Fonseca

Department of Nutrition Student Projects

Average life expectancy has steadily increased with each passing year and is estimated to continue increasing in years to come. Reports show that the number of people aged 65 or older has increased from 6% of the population in the 1960’s, to 12% in the year 2000, to 16% of the total population in 2015.¹ This number is expected to increase to almost 20% of the population by the year 2050.¹ Striving towards healthy aging can help the growing senior population to live the best possible life in their later years. Nutrition education is one area of learning …

A Photography-Based, Social Media Walking Intervention Targeting Autonomous Motivations For Physical Activity: Semistructured Interviews With Older Women, Michael C Robertson, Maria Chang Swartz, Ursela Christopherson, Jason R Bentley, Karen M Basen-Engquist, Debbe Thompson, Elena Volpi, Elizabeth J Lyons

Faculty, Staff and Students Publications

BACKGROUND: Older adult women are at risk for negative health outcomes that engaging in sustained physical activity can help prevent. However, promoting long-term maintenance of physical activity in this population has proven to be a challenge. Increasing autonomous motivations (ie, intrinsic, integrated, and identified regulations) for physical activity may facilitate enduring behavior change. Digitally delivered games for health that take a celebratory technology approach, that is, using technology to create new ways to experience valued behaviors and express valued beliefs, may be a useful way to target autonomous motivations for physical activity. Formative research with the target population is needed …

Families In The Sky: Investigating The Population Structure Of Pinus Longaeva, Samuel Arnold Decker

Theses and Dissertations

In the Western United States, the Great Basin is a geographic feature that is home to a variety of unique species, including Great Basin bristlecone pine (Pinus longaeva, PILO). P. longaeva is well known for the age of some of the trees, some of which are over 4000 years old. In this study 17 microsatellite markers (simple sequence repeat, SSR) are identified and used to genotype a selection of 480 individuals spread across 24 PILO populations and 60 individuals divided equally between 2 outgroup species, Pinus aristata and Pinus flexilis. One population of PILO, HMW, shows more genetic similarity with …

Illusory Effects On Stepping Over Obstacles After Lower Extremity Muscle Fatigue, Abayomi Gideon Adeyemo

Honors Capstones

No abstract provided.

Pharmacological Extension Of Lifespan Via Mitochondrial Uncoupling In Drosophila Melanogaster, Analisa Taylor

Honors Capstones

No abstract provided.

Microgreens Grow Kit: A Novel Pilot Study To Improve Nutrition Awareness, Ben Haslund-Gourley, Chris Para, Swaksha Rachuri, Sascha Enders, Rayna Marshall, Vibhuti Mishra, Simone Udeh, Jessica Nwabeke, Annette Gadegbeku

Transformative Medicine

Obesity and associated non-communicable illnesses including coronary heart disease, type 2 diabetes, and stroke have steadily increased in prevalence over the last decade. Previous studies identified the involvement of individual, family, and community support intervention strategies used to prevent and manage obesity. Additionally, education on nutrition from the early stages of development is crucial for obesity prevention and control. Therefore, new preventative methods are needed to further engage and educate individuals and communities about health-conscious diets. Microgreen cultivation utilizes a reduced cost, low-footprint, recyclable, weather-independent, and transportable method to provide less nutrition-privileged communities with exposure to healthy foods within one …

Alzheimer's And Patient Caregiver Burnout: A Review Of The Literature, Madeline Hekeler

James Madison Undergraduate Research Journal (JMURJ)

The term “silent epidemic” is fitting for Alzheimer’s disease (AD), as its negative impact is widely felt but rarely discussed. Burnout among AD caregivers has become an epidemic of its own as caregivers experience an increase in health risks, stress, and financial burden. This literature review focuses on caregiver burnout and how imperative it is that caregivers are better supported in their role. Researchers have developed instruments to assess and intervene in caregiver burnout that have shown effectiveness among caregivers and their families.Nevertheless, further longitudinal research is warranted regarding more effective interventions, including stress management and social support mechanisms.

Selection On Dispersal Drives Evolution Of Metabolic Capacities For Energy Production In Female Wing-Polymorphic Sand Field Crickets, Gryllus Firmus, Lisa A. Treidel, Gessen S. Quintanilla Ramirez, Dillon J. Chung, Michael Menze, Jose P. Vazquez-Medina, Caroline M. Williams

Faculty and Staff Scholarship

Life history and metabolism covary, but the mechanisms and individual traits responsible for these linkages remain unresolved. Dispersal capability is a critical component of life histories that is constrained by metabolic capacities for energy production. Conflicting relationships between metabolism and life histories may be explained by accounting for variation in dispersal and maximal metabolic rates. We used female wing-polymorphic sand field crickets, Gryllus firmus, selected either for long wings (LW) and flight-capability or short wings (SW) and high early lifetime fecundity to test the hypothesis that selection on dispersal capability drives the evolution of metabolic capacities. While resting metabolic …

Prostate-Specific Antigen Screening According To Health Professional Counseling And Age In The United States, Seth A. Otto, Ray M. Merrill

Library/Life Sciences Undergraduate Poster Competition 2022

To determine the prevalence of PSA testing in men according to age, reasons for undergoing testing, and whether a discussion about harms and benefits took place with a doctor prior to testing.

Collective Cognitive Capital, Emily R. D. Murphy

William & Mary Law Review

This Article calls for a new project for law and neuroscience. It outlines a structural, not individual, application of brain and behavioral science that is aligned with the general goal of basic science research: improving the lives of citizens with a better understanding of the human experience. It asks brain and behavioral science to move explicitly into public policy territory, and specifically onto ground more traditionally occupied by economists—but in ways the project of “behavioral economics” has not yet ventured. Put simply, policy analysts should focus on brains—“collective cognitive capital”—with the same intensity with which they focus on money, rights, …

Prenatal Exposure To Maternal Psychological Distress And Telomere Length In Childhood, Stephanie A. Stout-Oswald, Laura M. Glynn, Marco Bisoffi, Catherine H. Demers, Elysia Poggi Davis

Psychology Faculty Articles and Research

Telomere length (TL) is a biological marker of cellular aging, and shorter TL in adulthood is associated with increased morbidity and mortality risk. It is likely that these differences in TL are established long before adulthood, and there is growing evidence that TL can reflect prenatal experiences. Although maternal prenatal distress predicts newborn TL, it is unknown whether the relation between prenatal exposure to maternal distress and child TL persists through childhood. The purpose of the current longitudinal, prospective study is to examine the relation between prenatal exposure to maternal distress (perceived stress, depressive symptoms, pregnancy-related anxiety) and TL in …

Prevalence Of Sensory Impairments In Home Care And Long-Term Care Using Interrai Data From Across Canada, Dawn M. Guthrie, Nicole Williams, Atul Jaiswal, Paul Mick, Hannah M. O'Rourke, M. Kathleen Pichora-Fuller, Walter Wittich, Rinku Sutradhar

Health Sciences Faculty Publications

Background

In the general population, sensory impairments increase markedly with age in adults over 60 years of age. We estimated the prevalence of hearing loss only (HL), vision loss only (VL), and a combined impairment (i.e., dual sensory loss or DSL) in Canadians receiving home care (HC) or long-term care (LTC).

Methods

Annual cross-sectional analyses were conducted using data collected with one of two interRAI assessments, one used for the HC setting (n = 2,667,199), and one for LTC (n = 1,538,691). Items in the assessments were used to measure three mutually exclusive outcomes: prevalence of VL only, …

Affinity Of Cadmium Versus Zinc For The Carbonic Anhydrase Active Site, Rachel Phan

Honors Scholars Collaborative Projects

Cadmium is a heavy metal found in tobacco plants, nickel-cadmium batteries, and as a byproduct of metal mining. The similarities between the properties of zinc ions and cadmium ions in proteins due to their 2+ charges may cause displacement of zinc by cadmium if encountered and has been shown to do so in several transcription factors. Cadmium’s ability to replace zinc- a metal found in around 3,000 human proteins- is a cause for concern, especially due to its toxicity, long half-life in the body, and larger size.

Carbonic anhydrase is an important metalloprotein protein that relies on a central zinc(II) …

Exploratory Studies Of Oral And Fecal Microbiome In Healthy Human Aging., Xin Zhou, Baohong Wang, Patrick C Demkowicz, Jethro Johnson, Yanfei Chen, Daniel Spakowicz, Yanjiao Zhou, Yair Dorsett, Lei Chen, Erica Sodergren, George A Kuchel, George M. Weinstock

Faculty Research 2022

Growing evidence has linked an altered host fecal microbiome composition with health status, common chronic diseases, and institutionalization in vulnerable older adults. However, fewer studies have described microbiome changes in healthy older adults without major confounding diseases or conditions, and the impact of aging on the microbiome across different body sites remains unknown. Using 16S ribosomal RNA gene sequencing, we reconstructed the composition of oral and fecal microbiomes in young (23-32; mean = 25 years old) and older (69-94; mean = 77 years old) healthy community-dwelling research subjects. In both body sites, we identified changes in minor bacterial operational taxonomic …

Emerging Biomedical Applications Of The Vesicular Stomatitis Virus Glycoprotein, Sheeba Rehman, Suman Bishnoi, Rajarshi Roy, Anshu Kumari, Harikrishnan Jayakumar, Sharad Gupta, Parimal Kar, Asit K. Pattnaik, Bebasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Nanoparticles (NPs) made of metals, polymers, micelles, and liposomes are increasingly being used in various biomedical applications. However, most of these NPs are hazardous for long- and short-term use and hence have restricted biomedical applications. Therefore, naturally derived, biocompatible, and biodegradable nanoconstructs are being explored for such applications. Inspired by the biology of viruses, researchers are exploring the viral proteins that hold considerable promise in biomedical applications. The viral proteins are highly stable and further amenable to suit specific biological applications. Among various viral proteins, vesicular stomatitis virus glycoprotein (VSV-G) has emerged as one of the most versatile platforms for …

An Investigation Of The Sled-Push Exercise In Older Adults: Physiological Quantification, Perceived Enjoyment And Body Discomfort, Micheal A. Baumann

Graduate Research Theses & Dissertations

Healthy aging is defined as the process of maintaining and developing functional ability that allows a state of mental and physical wellbeing. Physical activity, particularly exercise training, has been highly recommended for individuals of all ages, especially older adults, as way to maintain, improve or restore functional ability and health. Different modalities and types of exercise have been successfully tested in older adults but not much is known about the potential of the sled-push exercise in this population, a modality that has been highly used among athletes to improve cardiorespiratory fitness, muscle strength and endurance, and core stability. PURPOSE: The …