Digital Commons Network^™

Invited Review: Effects Of Management On Performance Of Stocker Cattle And Subsequent Feedlot Performance: A Review Within Applied Animal Science, M.A. Snider, M.S. Gadberry, J.D. Rivera

Animal Science Faculty Publications and Presentations

Purpose: The purpose of this review is to summarize relevant research from the journal Applied Animal Science (formerly known as The Professional Animal Scientist) between 1995 and 2024, that explores management practices and concepts as they relate to stocker calf performance and subsequent feedlot performance. A secondary objective of this review is to describe research trends and identify knowledge and research gaps within existing literature. Sources: Sources for this article included peer-reviewed scientific literature obtained from the journal Applied Animal Science, formerly known as The Professional Animal Scientist. Literature used in this review included original research, short communications, technical notes, …

Hyperspectral Indicators And Characterization Of Glyphosate-Induced Stress In Common Lambsquarters (Chenopodium Album L.), Mario Soto, Aurelie M. Poncet, Nilda Roma-Burgos, O. Wesley France, Juan C. Velasquez, Amanda J. Ashworth, Kristofor R. Brye, Cengiz Koparan

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Hyperspectral sensors are increasingly used to develop optimized vegetation indices (VIs) that capture plant spectral response to specific stressors. The project goal was to develop quantitative metrics for characterization of weed response to herbicide application. This work applied hyperspectral sensing to describe and predict the spectral response of common lambsquarters (Chenopodium album L., CHEAL) to glyphosate application. Thirteen treatments, including one glyphosate rate used alone or in combination with eleven adjuvants plus one non- treated control, were applied to CHEAL seedlings cultivated in a greenhouse. Visible injury ratings and non- imaging hyperspectral data were collected 14 days after treatment application. …

A Multi-Isotope Investigation Of Mammoth Diet, Habitat, And Movement Patterns In The Central Great Plains, U.S.A., Jacob Mccloskey

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

During the Last Glacial Maximum (LGM), the Great Plains in Nebraska consisted of wooded parklands and grasslands, whereas spruce (Picea) forests, parklands, and steppe grasslands dominated east of the Missouri River. I analyzed bulk carbon (δ¹³C), oxygen (δ¹⁸O), and strontium (⁸⁷Sr/⁸⁶Sr) isotopes from tooth enamel in isolated mammoth (Mammuthus) molars to compare diet and movement patterns in two late Pleistocene assemblages: one in Nebraska (n = 24), and one in western Iowa and Missouri (n = 17). Furthermore, I identified a morphometric subset of molars as …

Alternative Therapeutics For Human Breast Cancer: Nutraceutical Underpinnings, In Vitro Metabolomic Profiling, Treatment Efficacy, And Contextual Ethical Implications, Aubrey A. Mattingly

All Dissertations

Breast cancer remains one of the most prevalent diseases worldwide, yet therapeutic equity is still lacking. Standard treatments including surgery, radiotherapy, chemotherapy, and long-term hormone therapy. These approaches are often accompanied by significant side effects. While newer methods such as immunotherapy and targeted therapies have emerged, chemotherapy protocols and incorporation have remained largely unchanged in the past decades. In this context, nutraceuticals represent an alternative or adjuvant to therapy worthy of exploration. The reviewed literature highlights the anti-carcinogenic activity in selected nutraceuticals, marjoram, thyme and persimmon, considering their phytochemical constituents and secondary metabolites. Metabolomic profiling using the Biolog Phenotype Mammalian …

Advanced Specificity And Sensitivity Studies Relative To A Research Use Only Transcription-Mediated Amplification-Based Assay For Treponema Pallidum Rna Detection, Trinity Krueger, Grace Kadonsky, Elizabeth Thelen, Amanda Zapp, Josephine Moore, Ahmet Muslu, Allan Pillay, Irene A. Stafford, Erik Munson

Clinical Lab Sciences Faculty Research and Publications

Preliminary experimentation has suggested that a research-use-only real-time transcription-mediated amplification assay for Treponema pallidum (RUO T. pallidum TMA) yields instances of T. pallidum nucleic acid detection that coincide with non-treponemal serology in men who have sex with men (MSM) at increased risk for sexually transmitted infection. To further characterize the specificity of RUO T. pallidum TMA testing, 3,586 rectal swab specimens reported as “not detected” by the assay generated a mean endpoint FAM fluorescence of 637.5 units. Introduction of Treponema denticola, Treponema phagedenis, and Treponema refringens nucleic acid into matrices generated mean endpoint FAM fluorescence ranging from 620.7 …

Multicenter Span Trial Of Fasudil In Ischemic Stroke, Takahiko Imai, Andreia Lopes De Morais, Xuyan Jin, Tao Qin, Jessica Lamb, Karisma A Nagarkatti, Mu-Hsun Chen, Ligia S B Boisserand, Rakesh B Patel, Mariia Kumskova, Anjali Chauhan, Krishnan M Dhandapani, Mohammad B Khan, Pradip K Kamat, Yanrong Shi, Suyi Cao, Basavaraju G Sanganahalli, Joseph B Mandeville, Patrick D Lyden, David C Hess, Enrique C Leira, Anil K Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Raymond C Koehler, Lauren H Sansing, Márcio A Diniz, Cenk Ayata

Children’s Nutrition Research Center Staff Publications

Background: The SPAN (Stroke Preclinical Assessment Network) is a confirmatory multicenter trial network to test cerebroprotective interventions in experimental acute stroke. In a first-of-its-kind trial, SPAN tested 6 interventions in a rodent model of transient focal ischemic stroke. Here, we report the efficacy of fasudil, an isoform-nonselective rho-associated kinase inhibitor, on primary and secondary outcomes in the SPAN trial.

Methods: Fasudil was administered at 10 mg/kg intraperitoneally every 12 hours for 6 doses starting 5 minutes before reperfusion in a 60-minute endovascular filament middle cerebral artery occlusion model. The active treatment arm (n=345) was compared with the pooled intraperitoneal and …

Family-Level Factors That Influence Physical Activity Among Hispanic Adolescents At Risk For Type 2 Diabetes, Sandra Mihail, Ayleen A Hernandez, Erica G Soltero

Children’s Nutrition Research Center Staff Publications

Objective: Family-based health promotion and disease prevention strategies are recommended as best practice; however, there is limited knowledge regarding the family-level factors that influence modifiable behavior risk factors like physical activity (PA) among Latinx adolescents. This study addressed this knowledge gap by using qualitative methods to identify perceptions of family-level factors that influence PA among Hispanic youth.

Methods: We conducted semistructured, open-ended interviews with 20 Latinx adolescents (14-16 years) with obesity (body mass index ≥95th percentile) to identify their perceptions of how family influences PA. Content analysis was used to identify emergent themes, which were then compared across demographic factors, …

Economic Contribution Of The Agricultural Sector To The Arkansas Economy In 2023, Frank Seo

AAES Research Reports and Research Bulletins

This report is the eighteenth in a series that examines agriculture’s economic contribution to the Arkansas economy. The total economic contribution of agriculture (direct, indirect, and induced effects) on value added, employment, and labor income was estimated with the Impact Analysis for Planning System (IMPLAN) for the most recent year available, 2023.

What's The Value Of A State? Accounting For The Ecosystem Services And Natural Capital Of Oregon, Kathryn Liebrecht

University Honors Theses

Ecosystem services are vital to human welfare and society, but often are overlooked when it comes to planning and setting policy. By neglecting to incorporate the benefits received from natural resources, policy makers may unknowingly be making decisions that harm the long term sustainability and use of these services. To highlight the importance of Oregon's ecosystems, the present study aims to provide a full accounting of the ecosystem services and natural capital of the state. Using data from the Institute for Natural Resources' updated Oregon statewide habitat map, Oregon's ecosystems were matched to biome categories from the Ecosystem Services Valuation …

Small Molecule Inhibitor 3i-1000 Dosed During Bouts Of Anoxia Increases Survivability Of Austrofundulus Limnaeus Embryos, Connor Kime

University Honors Theses

The annual killifish Austrofundulus limnaeus possesses exceptional tolerance to prolonged anoxia, offering a unique vertebrate model for investigating cardiac resilience and survival under metabolic stress. This study tested whether inhibition of the GATA4–NKX2-5 transcriptional axis with the small molecule 3i-1000 enhances post-anoxic survival. WS40 embryos were exposed to 50 µM 3i-1000 during anoxia and early aerobic recovery. Outcomes were assessed across two independent experimental cohorts. Treated embryos exhibited higher survivability during reoxygenation: in the October cohort, survival increased from 76.0% in vehicle controls (n = 25) to 91.7% in treated embryos (n = 24); in the November cohort, survival improved …

Effects Of Elevation, Fire Age, Burn Severity, And Pre-Fire Vegetation On Post-Fire Sagebrush Songbird Communities, William D. Harrod

All Graduate Theses and Dissertations, Fall 2023 to Present

The Sagebrush Biome of western North America has been threatened by a combination of interconnected threats. In the Great and Columbian Basins, a large portion of sagebrush loss has been due to an increase in higher-severity wildfires, caused by invasive annual grasses. As sagebrush declines, numerous wildlife species that rely on the biome have experienced similar trends. Sagebrush-adapted songbirds such as sage thrasher, Brewer's sparrow, and sagebrush sparrow as well as steppe-songbirds, have all experienced population declines. Currently, limited information exists as to how fire severity or recovery affect these songbirds or what resource managers can do to improve their …

Temperature Effects On Fruit Doubling And Bloom Prediction In Tart Cherry, Josette M. Moon

All Graduate Theses and Dissertations, Fall 2023 to Present

Tart cherry (Prunus cerasus) is a key horticultural crop in Utah. Extreme summer heat and cold weather in late spring are challenges to tart cherry production causing economic losses. These problematic weather conditions are influenced by the local landscape and are exacerbated by changing climate. This research explores (1) the impact of summer heat stress on fruit deformities, and (2) the accuracy of temperature-based predictions of spring bud development. High temperatures and water stress after harvest are known to cause a deformity known as twin or double fruits, resulting in unmarketable fruit. This disorder has been studied in …

Role Of Cellular Proteins In The Regulation Of Herpes Simplex Virus Type 1 Gene Expression And Dna Replication, Joseph R. Heath

Electronic Theses and Dissertations

Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen that infects the majority of the human population. To facilitate infection, this virus relies on a combination of host and viral factors. Previous studies have revealed a number of host proteins that associate with the HSV-1 genome throughout infection but their putative role(s) in this process remain undefined. This study aims to examine two such proteins to determine their contributions to HSV-1 gene expression and DNA replication. The first of these factors is Ints3, a subunit of the Integrator complex. This protein complex functions in transcription regulation, and Ints3 …

Exploring Variability Of The Cg18562578 Methylquant Assay For The Forensic Discrimination Of Monozygotic Twins, Sydney E. Arnold

Student Theses

Monozygotic (MZ) twins possess identical DNA sequences, posing a problem for forensic scientists, as they are incapable of distinguishing MZ twins from each other using traditional DNA identification methods. However, the epigenomes of MZ twins will differ and might be used for their forensic discrimination. Here, we explored the variability of an assay previously developed by our laboratory that showed high discrimination potential for MZ twins using buccal swab DNA, cg18562578 MethylQuant. We measured precision at each step: bisulfite conversion, nested PCR, and qPCR, reproducibility, and repeatability. DNA methylation ratios were compared between two analysts carrying each step using the …

Investigating Rattlesnake Social Networks And Improving Their Public Image Through Unobtrusive Technologies And Community Science, Owen M. Bachhuber

Master's Theses

While technology is often blamed for humans’ increasing disconnect with nature, it can also serve as a tool to facilitate empathy and conservation action for wildlife. Snakes are among the most feared animals on the planet, though their understudied social interactions provide opportunities to make scientific discoveries and change public perceptions. Project RattleCam was founded as a camera trap project in 2021 and launched the first off-grid livestream on a den of wild Prairie Rattlesnakes (Crotalus viridis) in 2024. Both camera types captured hundreds of Prairie Rattlesnakes gathering in the summer as they prepared to give birth to pups before …

Six Lineages Of Cercospora Are Responsible For Cercospora Leaf Blight And Purple Seed Stain On Soybean In Brazil, Leandro Luiz Borges, Thiago Freitas Ferreira, Marina Garofalo Lana, Isabela Delpupo Caliman, Newton Deniz Piovesan, Burton H. Bluhm, Luiz Orlando De Oliveira

Plant Pathology Faculty Publications and Presentations

The genus Cercospora is widely distributed and causes foliar diseases, including those affecting soybean. Cercosporoid species exhibit high intraspecific variation, and the lack of distinct morphological features has led to host plant association becoming a key criterion for species delimitation. Recently, in addition to C. kikuchii, other species such as C. cf. flagellaris, C. cf. sigesbeckiae, and C. cf. nicotianae have been linked to Cercospora Leaf Blight (CLB) and Purple Seed Stain (PSS) in soybean. In this study, phylogenetic and phylogeographic analyses were used to identify six Cercospora lineages responsible for causing CLB and PSS across Brazil. A total of …

Activation And Suppression Mechanisms Of The Nrg1 Helper Nlrs, Yu-Ru Wang, Ruize Zhang, Daowen Wang, Yong Wang, Zheng Qing Fu

Faculty Publications

No abstract provided.

Cg18562578 Methylquant Assay For The Discrimination Of Monozygotic Twins, Amber P. Chauca

Student Theses

Monozygotic (MZ) twins have identical DNA, making traditional profiling methods insufficient in their discrimination. However, MZ twins can be differentiated by their levels of DNA methylation. Our research group previously developed a methodology to detect cg18562578 DNA methylation levels in MZ twins based on a two- step PCR approach and a cg18562578 MethylQuant Assay. That study generated data for only 64% of the samples it investigated, and showed a discrimination power of 77% to discriminate between MZ twins. Here, we used the same methodology but a different approach to determine DNA methylation in 73 previously unsuccessful twin pairs. We diluted …

From Cities To Ranches: Assessing Public Support For Jaguar (Panthera Onca) Conservation And Livestock Predation In Colombia, Luz Angelica Solano

All Dissertations

Jaguars are among the most emblematic large carnivores worldwide. Nonetheless, the species has declined by 25% in less than 25 years and their range has been reduced by 55%, approximately, primarily due to habitat loss from increasing agricultural development, retaliatory killings from human-jaguar conflict, and overhunting of their natural prey. Given the anthropogenic nature of these threats, developing effective coexistence strategies and public support for jaguar conservation are increasingly urgent for the continued persistence of this species. I conducted a scoping review to assess trends and gaps in the existing peer-reviewed literature, grey literature, and news articles related to human-jaguar …

Generation Of Ph-Responsive Starch And Alginate-Pectin Hydrogels Using Coaxial 3d Food Printing: The Release Of Methylene Blue, Que-Anh Truong-Le, Matthias D.R. Lenie, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

This article presents the development of a 3D food printing (3DFOODP) system incorporating a core-shell structure to encapsulate a model compound, methylene blue (MB). A coaxial nozzle configuration was employed to fabricate 3D-printed samples, featuring a starch core and a pH-responsive alginate-pectin (Al-P) shell. The optimal 3D printing conditions were determined as 11 wt% starch as the core along with 2 wt% Al-P with 0.02 M CaCl2 as the shell at printing temperatures of 95 degrees C and ambient temperature (23 degrees C), respectively. The overall 3D printability at this condition was 98 %, closely matching the digital 3D design. …

An Evaluation Of Key Components Of Natural Resource Camps, Undergraduate Persistence And Success In Natural Resources, Brandy Bishop

Electronic Theses and Dissertations

This study explores the key components that connect natural resource camps, undergraduate persistence, and overall success through gainful employment within the natural resource industry. The aim of this study was to assess early interest and attitudes towards natural resource career pathways and how education interventions shape students’ career outcomes thus leading to overall success. A longitudinal mixed method design was used combining Conservation Careers Camp survey data (n = 39) with institutional records for Forestry majors (n =655) in the Arthur Temple College of Forestry and Agriculture on the Stephen F. Austin State University campus. Quantitative data was analyzed through …

The Influence Of Psychological, Biological, And Social Determinants On Disordered Eating Behaviors Among U.S. Young Adults: Evidence From Nhanes 2015-2018., Samantha Kaye Gerbine

Electronic Theses and Dissertations

Disordered eating behaviors (DEBs) are influenced by biological, social, and psychological factors, yet research often narrowly focuses on White, college-aged women. This study assessed the predictors and prevalence of DEBs in a nationally representative sample of U.S. young adults using data from the 2015–2018 National Health and Nutrition Examination Survey (NHANES). Survey weights were applied to generate national estimates. Descriptive statistics characterized the sample, and logistic regressions tested biological, social, and psychological predictors of DEBs. A composite risk score was developed using variables retained in the final model. The unweighted sample (n = 1,062) represented 64 million U.S. young adults. …

Blackberry Long-Cane Cold Storage And Forcing Strategy Effects On Flower And Fruit Development, Leala Machesney, Ryan Dickson, Amanda Mcwhirt, Margaret L. Worthington, Stephanie E. Burnett

Horticulture Faculty Publications and Presentations

Blackberry (Rubus subg. Rubus) production using soilless culture and "long-cane" techniques offers growers the potential to achieve off-season harvests and increase yields. This study investigated the feasibility of achieving early spring harvests and high yields with four blackberry cultivars (Natchez, Ouachita, Prime-ArkVR Freedom, and Prime-ArkVR Traveler) grown using long-cane techniques and six different cold storage and forcing environment strategies. Long-cane blackberry plants were container-grown outdoors during 2020 and were overwintered either at an outdoor nursery or in a cold storage facility (4 degrees C). Dormant plants were then forced the following spring at the outdoor nursery location or in a …

Crystal Structures Of Escherichia Coli Glucokinase And Insights Into Phosphate Binding, Joseph Andrews, Joshua Sakon, Chenguang Fan

Chemistry & Biochemistry Faculty Publications and Presentations

Here, we report the crystal structure of Escherichia coli glucokinase (GLK), which has phosphate bound in the cleft between the alpha and beta domains adjacent to the active site. A ternary complex consisting of GLK, glucose and phosphate is also reported in this work. Diffraction data were collected at 2.63 angstrom resolution for the phospate-bound form (R-work/R-free = 0.191/0.230) and at 2.54 angstrom resolution for the ternary complex (R-work/R-free = 0.202/0.258), both at 297 K. A B-factor analysis of the phosphate-bound GLK structure revealed consistently lower values for phosphate-interacting basic residues in the alpha 4, alpha 5 and alpha 9 …

Hierarchy In Sensation: Exploring The 40 Hz Auditory Steady State Synchrony In The Primary Auditory And Prefrontal Association Cortices, Deepshila Gautam

Electronic Theses and Dissertations

Auditory processing begins in the cochlea and ascends through brainstem relays to the cortex, where sound features with increasing complexity are encoded. The 40 Hz auditory steady-state response (ASSR) reflects induced gamma synchrony shaped by local cortical circuit dynamics. Disrupted 40 Hz ASSR is a consistent finding in schizophrenia, linked to N-methyl-D-aspartate receptor (NMDAR) hypofunction in inhibitory interneurons, making it a promising translational biomarker. While multiple ASSR generators have been identified, it is not known if these are redundant or represent unique activity. This dissertation investigates regional differences in 40 Hz ASSR across two principal generators: the primary auditory cortex …

Sex Differences In The Risk Of Developing Alzheimer Disease, Cognitive Trajectories, And Relationships Between Cognition And Pathological Burden, Carling G. Robinson

Arts & Sciences Graduate Student Theses and Dissertations

Prior work suggests females may develop Alzheimer disease (AD) dementia at a higher rate than males, and that this effect may interact with apolipoprotein (APOE) ε4 genotype. However, this work has often been limited by imprecise clinical diagnoses and a lack of AD biomarkers. In addition to the frequency of dementia, there are mixed reports on whether sex impacts rates of cognitive decline. Further, females consistently exhibit greater accumulation of AD pathological biomarkers, particularly tau, than males. It has been theorized that females initially demonstrate resilience to AD pathology, maintaining cognitive functioning longer than males, but experiencing a steeper cognitive …

Consensus Statement On The Prevention And Management Of Complications Of Fully Ablative Laser Resurfacing Of The Face, Bianca Y Kang, Joel L Cohen, Roy Geronemus, Suzanne L Kilmer, Edward Victor Ross, Elizabeth L Tanzi, Jill S Waibel, Brian J F Wong, Murad Alam, Macrene Alexiades, Kenneth A Arndt, Mathew Avram, Ashish C Bhatia, Brian Stuart Biesman, Jason D Bloom, A Jay Burns, Henry H L Chan, Catherine M Digiorgio, Jeffrey S Dover, Sam Fathizadeh, Sara C Esteves, Michael H Gold, Gerald N Goldberg, Merete Haedersdal, Elika Hoss, Omar A Ibrahimi, H Ray Jalian, Kristen M Kelly, Woraphong Manuskiatti, Lisa A Marks, Girish S Munavalli, Jason N Pozner, Chris W Robb, Anthony M Rossi, Nazanin Saedi, Peter R Shumaker, Kelly Stankiewicz, Molly Wanner, Douglas C Wu, Adam J Wulkan, Arisa Ortiz

Faculty, Staff and Student Publications

Objectives: To achieve consensus among expert laser surgeons on standards for the prevention and management of adverse events from fully ablative laser resurfacing of the face.

Materials and methods: Delphi study with two rounds of ratings and revisions until consensus was achieved. The draft set of statements was developed by a steering committee based on expert clinical experience. This was followed by two rounds of rating and revisions completed by an expert panel, then a virtual consensus meeting. In both rounds, respondents rated the draft statements on a 9-point Likert scale (1 = strongly disagree; 9 = strongly agree) and …

Bayesian Counterfactual Machine Learning Individualizes Radiation Modality Selection To Mitigate Immunosuppression, Duo Yu, Michael J Kane, Yiqing Chen, Steven H Lin, Radhe Mohan, Brian P Hobbs

Faculty, Staff and Student Publications

Purpose: Lymphocytes play critical roles in cancer immunity and tumor surveillance. Radiation-induced lymphopenia (RIL) is a common side effect observed in patients with cancer undergoing chemoradiation therapy (CRT), leading to impaired immunity and worse clinical outcomes. Although proton beam therapy (PBT) has been suggested to reduce RIL risk compared with intensity-modulated radiation therapy (IMRT), this study used Bayesian counterfactual machine learning to identify distinct patient profiles and inform personalized radiation modality choice.

Methods: A novel Bayesian causal inferential technique is introduced and applied to a matched retrospective cohort of 510 patients with esophageal cancer undergoing CRT to identify patient profiles …

Development Of A Multi-Institutional Dataset To Validate A Novel Inflammatory Breast Cancer Diagnostic Score, Filipa Lynce, Samuel M Niman, Megumi Kai, Sean Ryan, Elizabeth Troll, Li Li, Kathy D Miller, Reshma Jagsi, Ginny Mason, Beth A Overmoyer, H T Carisa Le-Petross, Faina Nakhlis, Savitri Krishnamurthy, Beth T Harrison, Susie X Sun, Eren D Yeh, Jennifer R Bellon, Laura E Warren, Michael C Stauder, Meredith M Regan, Wendy A Woodward

Faculty, Staff and Student Publications

Background: Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinicians, and researchers to propose novel quantitative scoring rubrics for IBC diagnosis. In this study, we developed a multi-institutional clinical dataset to test and validate the proposed scoring system.

Methods: IBC (N = 988) and non-IBC (N = 332) cases were identified at 2 institutions with dedicated multidisciplinary IBC programs. The non-IBC cohort included consecutive cT4b and cT4c patients. Standard operating procedures (SOPs) were developed for all ambiguous findings and languages. Three different methods were used for the imputation of missing data, …

Vascular Risk Factors And 1-Year Cognitive Change Among Individuals With Traumatic Brain Injury, Andrea L. C. Schneider, Katherine Hunzinger, Benjamin L. Brett, Danielle K Sandsmark, Sonia Jain, Xiaoying Sun, Raquel C. Gardner, Geoffrey T. Manley, Ramon Diaz-Arrastia, Lindsay D. Nelson, Patrick Belton, Shawn Eagle, Shankar Gopinath, Ramesh Grandhi, C. Dirk Keene, Vijay Krishnamoorthy, Christine Mac Donald, Michael Mccrea, Randall Merchant, Pratik Mukherjee, Laura B. Ngwenya, David Okonkwo, Claudia Robertson, David Schnyer, Sabrina R. Taylor, John K. Yue, Ross Zafonte

Department of Exercise Science Faculty Papers

IMPORTANCE: Traumatic brain injury (TBI) and vascular risk factors are associated with cognitive impairment, but it is unknown if individuals with vascular risk factors experience worse cognitive outcomes after TBI.

OBJECTIVE: To evaluate cognitive function among patients with TBI with vs without comorbid preinjury vascular risk factors.

DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study examined individuals with TBI enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) Study between February 26, 2014, and August 8, 2018, with a 1-year follow-up. Analyses were conducted February 26, 2024, to May 29, 2025.

EXPOSURES: Vascular risk factors (ie, hypertension, diabetes, …