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Tolle Lege Works Published In 2018, Mcquade Library

Bibliographies

Compiled Tolle Lege bibliography of works published by members of the Merrimack College Community in 2018. Works include journal articles, books, book chapters, conference presentations and posters, and more.

Speciation Theory Of Carcinogenesis Explains Karyotypic Individuality And Long Latencies Of Cancers, Ankit Hirpara, Mathew Bloomfield, Peter Duesberg

Natural Sciences and Mathematics | Student Professional Publications

It has been known for over 100 years that cancers have individual karyotypes and arise only years to decades after initiating carcinogens. However, there is still no coherent theory to explain these definitive characteristics of cancer. The prevailing mutation theory holds that cancers are late because the primary cell must accumulate 3–8 causative mutations to become carcinogenic and that mutations, which induce chromosomal instability (CIN), generate the individual karyotypes of cancers. However, since there is still no proven set of mutations that transforms a normal to a cancer cell, we have recently advanced the theory that carcinogenesis is a form …

Phosphorus Limitation Of Aboveground Production In Northern Hardwood Forests, Shinjini Goswami, Melany C. Fisk, Matthew A. Vadeboncoeur, Mariann Garrison-Johnston, Ruth D. Yanai, Timothy J. Fahey

All Materials

Forest productivity on glacially derived soils with weatherable phosphorus (P) is expected to be limited by nitrogen (N), according to theories of long-term ecosystem development. However, recent studies and model simulations based on resource optimization theory indicate that productivity can be co-limited by N and P. We conducted a full factorial N × P fertilization experiment in 13 northern hardwood forest stands of three age classes in central New Hampshire, USA, to test the hypothesis that forest productivity is co-limited by N and P. We also asked whether the response of productivity to N and P addition differs among species …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2017, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The 2017 Annual Technical Report for Kentucky consolidates reporting requirements for the Section 104(b) base grant award into a single document that includes: 1) a synopsis of each student research enhancement project that was conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the period, and 5) notable awards and achievements.

No funds were requested for general program administration activities. However, travel funds were provided to support the participation of the director and associate director in the annual meeting of the National Institutes …

Increased Fxyd1 And Pgc-1Α Mrna After Blood Flow-Restricted Running Is Related To Fibre Type-Specific Ampk Signalling And Oxidative Stress In Human Muscle, Danny Christiansen, Robyn M. Murphy, Christos G. Stathis, David Bishop

Research outputs 2014 to 2021

Aim: This study explored the effects of blood flow restriction (BFR) on mRNA responses of PGC-1α (total, 1α1, and 1α4) and Na+,K+-ATPase isoforms (NKA; α1-3, β1-3, and FXYD1) to an interval running session and determined whether these effects were related to increased oxidative stress, hypoxia, and fibre type-specific AMPK and CaMKII signalling, in human skeletal muscle. Methods: In a randomized, crossover fashion, 8 healthy men (26 ± 5 year and 57.4 ± 6.3 mL kg−1 min−1) completed 3 exercise sessions: without (CON) or with blood flow restriction (BFR), or in systemic hypoxia (HYP, ~3250 m). A muscle sample was collected …

Role Of Bovine Ileal Sub-Epithelial Myofibroblasts And Epithelial Cells In Innate Immunity, Tirth Uprety

Electronic Theses and Dissertations

Gastro-intestinal (GI) tract harbors largest number of microbiota as well as the largest number of immune cells for a given tissue. The host needs to mount an effective immune response against invading pathogens and tolerance against commensals. Thus, regulatory mechanism and barrier function of the GI tract are of utmost importance for appropriate host microbe interaction and gut homeostasis. Intestinal epithelial cells (IECs) act as the first line of defense against invading pathogens. IECs recognize pathogens and commensals and mount an effective innate immune response. Such recognition of pathogens is mediated through germ line encoded pattern recognition receptors (PRRs). Intestinal …

Relationship Between New Farming Practices And Chemical Use And The Consumption Of Giant Cricket (Brachytrupes Membranaceus Drury, 1770), F. O. Miantsia, F. Meutchieye, S. Niassy

All Peer-Reviewed Publications

The current work is aimed at generating information on giant crickets and the impact of commonly used pesticides on the natural population of these crickets. Data was collected based on interviews and complemented with field observations. Out of 319 respondents surveyed, 290 were aware of the use of the giant cricket as a food source, and 161 were active consumers. Regarding the availability of the giant cricket, respondents reported that the crickets' populations were diminishing because of farming practices. About 219 persons reported that commonly used herbicides harm giant crickets at different stages. This could be attributed to the scarcity …

Do The Lifetime Prevalence And Prognosis Of Schizophrenia Differ Among World Regions?, Cheryl Lynn Smith

CMC Senior Theses

Much cross-cultural research has been done on the topic of schizophrenia, but few studies thus far have focused on lifetime prevalence and prognosis together, grouped by world region. Additionally, there has been severe bias in which countries and regions have been studied both historically and currently. Any study that had statistics on lifetime prevalence per 1000 people and/or DALYs, from a specified country or region, was included in this thesis. Results showed that lifetime prevalence of schizophrenia does not differ among WHO regions, but DALYs and thus prognosis do differ. Several major conclusions can be drawn from these results. One …

The Response Of Unpolarized Macrophages (Raw 264.7)/Keratinocytes (Pam-212) Monolayer And Co-Culture System To Herpes Simplex Virus Type 1 (Hsv-1) Replication During The Infection., Fahad Mohammed Alradi

Browse all Theses and Dissertations

Keratinocytes and neurons cells are the main target for Herpes Simplex Virus Type 1 (HSV-1) invasion. Moreover, keratinocytes are the most abundant cell types in the epidermis layer in the skin. Therefore, they are the first cells to encounter HSV-1 in the primary infection. Next, the virus reaches the nerve endings and is transferred to neuronal cells as a result from the primary infection. In between these two events, innate immune cells including monocytes and macrophages response is activated and recruited to the infection site. In this study, keratinocytes (PAM-212) and murine macrophage (RAW 264.7) cell lines were utilized to …

Callus Production And Analysis Of Some Secondary Metabolites In Globularia Trichosantha Subsp. Trichosantha, Hati̇ce Çölgeçen, Havva Atar, Gülnur Toker, Gençay Akgül

Turkish Journal of Botany

This study describes the production of calli from Globularia trichosantha subsp. trichosantha and the quantitative determination of catalpol, aucubin, and verbascoside in the calli and the plant by HPLC. The seeds of the plant were sterilized and germinated in Murashige and Skoog (MS) medium without in vitro plant growth regulator. Hypocotyl, cotyledon, first leaf, epicotyl, apical meristem, and root explants were taken from the 30-day-old aseptic seedlings germinated in vitro. Explants were then transferred to MS media for callus production together with varying concentrations of plant growth regulators. The best callus production occurred in the media containing 6 mg L?1 …

Hsa-Mir-301a- And Sox10-Dependent Mirna-Tf-Mrna Regulatory Circuits Inbreast Cancer, Yasemi̇n Öztemur Islakoğlu, Senem Noyan, Bala Gür Dedeoğlu

Turkish Journal of Biology

Breast cancer is the most common cancer among women and the molecular pathways that play main roles in breast cancer regulation are still not completely understood. MicroRNAs (miRNAs) and transcription factors (TFs) are important regulators of gene expression. It is important to unravel the relation of TFs, miRNAs, and their targets within regulatory networks to clarify the processes that cause breast cancer and the progression of it. In this study, mRNA and miRNA expression studies including breast tumors and normal samples were extracted from the GEO microarray database. Two independent mRNA studies and a miRNA study were selected and reanalyzed. …

Role Of Lipid Peroxide Derived Dicarboxylic Acids In Atherosclerotic Calcification, Aladdin Riad

Electronic Theses and Dissertations

Cardiovascular diseases, including atherosclerosis, are the leading cause of death in the United States. Atherosclerotic lesions are formed by deposition of lipids in the intima of arteries. Upon exposure to oxidative stresses, low-density lipoprotein (LDL) is converted to highly atherogenic oxidized LDL (ox-LDL) particles, contributing to disease development and progression. Advanced disease stages may result in calcification of lesions. This calcification process is important, as it has been shown to be associated with stable plaques that are less prone to rupture. Calcification is present in lipid rich domains of lesions, however neither the composition of the mineralized calcium deposits nor …

Knowledge And Attitudes Regarding The Recent Zika Outbreak Among A Sample Of South Florida Residents, Mohamed Elakkari

Electronic Theses and Dissertations

South Florida has had the largest number of U.S. Zika infection cases during the recent outbreak. This study aimed at assessing South Floridians' basic knowledge, perceptions of the seriousness and susceptibility to Zika infection, their information sources and needs, as well as their attitudes towards the protective measures proposed by the CDC. We also wanted to assess whether any of those factors have affected the frequency of participants' undertaking of the protective behaviors. To this end, we designed an online questionnaire and surveyed the responses of five hundred South Floridians (Age=18-78 years). We found significant gaps in participants' knowledge about …

Effects Of Aldosterone On Striatin And Caveolin-1 Protein Levels In Rat Kidney: Role Of Mineralocorticoid Receptor, Kevalin Inthachart

Chulalongkorn University Theses and Dissertations (Chula ETD)

The mineralocorticoid hormone aldosterone is a steroid hormone which plays an important role in maintenance of sodium, potassium, and acid-base balance. Aldosterone actions are mediated by mineralocorticoid receptor (MR) that could operate via genomic or nongenomic pathways. It has been shown that MR forms a complex with several molecules including scaffolding proteins, such as striatin and caveolin-1 (cav-1). Previous in vitro studies demonstrated that aldosterone increased striatin and cav-1 protein abundance. In addition, both striatin and cav-1 could interact with MR. However, there is no in vivo study of aldosterone effects on striatin and cav-1 protein levels in rat kidney. …

Physico-Chemical Properties Of Extruded Aquafeed Pellets Containing Black Soldier Fly (Hermetia Illucens) Larvae And Adult Cricket (Acheta Domesticus) Meals, F. G. Irungu, C. M. Mutungi, A. K. Faraj, H. Affognon, N. Kibet, C. Tanga, S. Ekesi, D. Nakimbugwe, K. K.M. Fiaboe

All Peer-Reviewed Publications

Fish farming is faced with the challenge of high cost of feeds because of the cost of high quality protein needed for formulation of the feeds. Thus, there is urgent need for alternative protein sources. The effects of substituting freshwater shrimp meal (FWSM) with black soldier fly larvae meal (BSFM) or adult cricket meal (ACM) on physico-chemical properties of hot-extruded fish feed pellets were investigated. The FWSM protein in a 26 g/100 g protein fish feed formulation was substituted at 0, 25, 50 and 75%, and moisture content of the formulated blends adjusted to 10, 20 or 30 g/100 g …

Diapause Disruption In Cirina Butyrospermi Vuillet (Lepidoptera, Attacidae), The Shea Caterpillar, In Burkina Faso, H. B. Bama, R. A. Dabire, D. Ouattara, S. Niassy, M. N. Ba, D. Dakouo

All Peer-Reviewed Publications

The shea caterpillar Cirina butyrospermi is an important insect, highly valued as a human food item in Burkina Faso. However, its appearance is seasonal due to its univoltine cycle. This study therefore investigated the possibilities of breaking the nymphal diapause by changing the environmental factors and through the hormonal treatment of prepupae and pupae using bovine insulin and 20-hydroxyecdysone. Changes in humidity and temperature did not result in emergence, suggesting a mandatory nature of the diapause in C. butyrospermi. Injection of 20-hydroxyecdysone between 20 and 40 ng on 20 C. butyrospermi pupae resulted in 15.24 and 47.5% emergence, respectively. The …

Tumor Multicomponent Targeting Polymer-Lipid Hybrid Nanoparticles To Overcome Drug Resistance In Renal Cell Carcinoma, Hashem Obaid Alsaab

Wayne State University Dissertations

Renal Cell Carcinoma (RCC) contributes to more than 90% of the most common form of kidney tumor and remains one of the ten leading causes of cancer death in the United States. Although surgery remains an option for operable tumors, high metastatic index and resistance to radiation and chemotherapies prompted recent development of therapeutics that target the RCC angiogenesis and cell proliferation pathways. Tyrosine kinase inhibitors or TKIs (Cabozantinib, Axitinib, Sorafenib, and Sunitinib) and mammalian target of rapamycin (mTOR) inhibitors (Temsirolimus and Everolimus) have increased the therapeutic options for treating RCC. Although the impact towards decreasing disease progression is encouraging, …

Comparison Of Neuroprotective Efficacy Of Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Following Permanent Middle Cerebral Artery Occlusion In The Wistar Rat And In Vitro Toxicity Studies, Diego Melani, Megan C. Bakeberg, Jane L. Cross, Vince W. Clark, Ryan S. Anderton, David J. Blacker, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

We have previously demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties, with poly-arginine peptide R18 identified as being highly effective at reducing infarct volume following middle cerebral artery occlusion (MCAO) in the Sprague Dawley rat. Since peptides synthesised using D-isoform amino acids have greater stability than L-isoform peptides due to increased resistance to proteolytic degradation, they represent potentially more effective peptide therapeutics. Therefore we compared the neuroprotective efficacy of R18 and its D-enantiomer R18D following permanent MCAO in the Wistar rat. Furthermore, as increased peptide stability may also increase peptide toxicity, we examined the effects of R18 and …

Proximate Composition And In Vitro Protein Digestibility Of Extruded Aquafeeds Containing Acheta Domesticus And Hermetia Illucens Fractions, F. G. Irungu, C. M. Mutungi, A. K. Faraj, H. Affognon, S. Ekesi, D. Nakimbugwe, K. K.M. Fiaboe

All Peer-Reviewed Publications

Major protein sources for feed manufacture have become costly, and this has led to increased cost of products such as aquafeeds. This has dampening effect on fish production especially in developing countries, and has necessitated a search for alternative protein sources in processed feeds. The effects of extrusion on aquafeed blends containing fractions of adult cricket (Acheta domesticus) meal (ACM) or black soldier fly (Hermetia illucens) pre-pupae meal (BSFM) on proximate composition and in vitro protein digestibility were investigated. Extrusion resulted in higher contents of protein and nitrogen free extract, and lower contents of ether extract and crude fibre as …

Suitability Of Egg Hatching Conditions And Commonly Available Food Plants For Rearing The Long-Horned Grasshopper Ruspolia Differens Serville (Orthoptera: Tettigoniidae), G. Ssepuuya, C. M. Tanga, I. Yekko, F. Sengendo, C. T. Ndagire, K. K.M. Fiaboe, J. Karungi, D. Nakimbugwe

All Peer-Reviewed Publications

Efforts to promote sustainable production and processing of Ruspolia differens Serville (Orthoptera: Tettigoniidae) as a viable agribusiness model for enhancing food and nutrition security have gained momentum. However, the inexistence of rearing techniques adapted to this insect creates uncertainty regarding the effectiveness of up-scaling production. This study evaluated the effect of five temperatures (26, 28, 30, 32 and 34 °C) on egg development time, percentage hatchability and nymphal weight at hatching. It also evaluated the average weekly wet weight attained by R. differens and percentage survival during growth when reared at 30 °C on four different food plant diets. The …

Molecular And Evolutionary Analysis Of Cyanobacterial Taxonomic Methods, Chelsea Denise Villanueva

UNF Graduate Theses and Dissertations

Cyanobacteria are a group of photo-oxygenic bacteria found in nearly every ecosystem, but much cyanobacterial diversity, in various habitats, has yet to be explored. Cyanobacteria are often conspicuous components of photosynthetic flora, providing significant carbon and nitrogen inputs to surrounding systems. As possible primary colonizers of stone substrates not native to this region, cyanobacteria isolated from headstones may provide biogeographically informative data. An exploratory study of lichen-dominated microbial consortia, growing on headstones, was conducted to isolate and identify novel microaerophytic cyanobacteria, and resulted in the establishment of four novel cyanobacterial taxa. Phylogenetic analyses of photobionts in one tripartite lichen revealed …

Why Do We Want To Think Humans Are Different?, Colin A. Chapman, Michael A. Huffman

Animal Sentience

One harmful consequence of creating categories where one group is unique and superior to others is that it justifies committing negative, often atrocious, acts on the members of the inferior group. Correcting divisive human categorizations (racial superiority, gender superiority) has bettered society. Scholars have often claimed that humans are unique and superior to nonhuman animals. These claims need to be reevaluated. Many have already been refuted. Animals have been shown to outperform humans in many tasks, including cognitive ones. Here we raise the question: Has the false sense of superiority been used to justify human cruelty to animals?

Longitudinal Cerebrospinal Fluid Biomarkers Of Alzheimer Disease: Movement Toward The Diagnosis, Prognosis And Staging Of Disease, Courtney Sutphen

Arts & Sciences Graduate Student Theses and Dissertations

Alzheimer’s disease (AD) is a devastating neurodegenerative disease that slowly claims the memories and experiences that comprise the life experiences of individuals that suffer from the disease. Despite a continually accelerating pace of research and discovery, a viable therapeutic intervention for AD has yet to be realized. There are a multitude of factors that may contribute to this difficulty including the challenge of separating the overall disease of Alzheimer’s from the clinically recognizable memory loss that occurs in what is now known to be the end-stage of the disease. Efforts to treat AD have increasingly turned toward very early disease …

Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton

Articles

This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca₁₀(PO₄)₆F₂) and bioinert mullite (Si₂Al₆O₁₃) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched …

Endonucleolytic Cleavage In The Expansion Segment 7 Of 25s Rrna Is An Early Marker Of Low-Level Oxidative Stress In Yeast, Daniel Shedlovskiy, Jessica A Zinskie, Ethan Gardner, Dimitri G Pestov, Natalia Shcherbik

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The ability to detect and respond to oxidative stress is crucial to the survival of living organisms. In cells, sensing of increased levels of reactive oxygen species (ROS) activates many defensive mechanisms that limit or repair damage to cell components. The ROS-signaling responses necessary for cell survival under oxidative stress conditions remain incompletely understood, especially for the translational machinery. Here, we found that drug treatments or a genetic deficiency in the thioredoxin system that increase levels of endogenous hydrogen peroxide in the yeast Saccharomyces cerevisiae promote site-specific endonucleolytic cleavage in 25S ribosomal RNA (rRNA) adjacent to the c loop of …

Lingnan Gardeners Newsletter (No. 34) = 嶺南彩園通訊 (第34期), Lingnan Gardeners, Kwan Fong Cultural Research And Development Programme, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

Wisteria 紫藤花

What Controls Variation In Carbon Use Efficiency Among Amazonian Tropical Forests?, Christopher E. Doughty, Gregory R. Goldsmith, Nicolas Raab, Cecile A. J. Girardin, Filio Farfan-Amezquita, Walter Huaraca-Huasco, Javier E. Silva-Espejo, Alejandro Araujo-Murakami, Antonio C. L. Da Costa, Wanderley Rocha, David Galbraith, Patrick Meir, Dan B. Metcalfe, Yadvinder Malhi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Why do some forests produce biomass more efficiently than others? Variations in Carbon Use Efficiency (CUE: total Net Primary Production (NPP)/ Gross Primary Production (GPP)) may be due to changes in wood residence time (Biomass/NPP_wood), temperature, or soil nutrient status. We tested these hypotheses in 14, one ha plots across Amazonian and Andean forests where we measured most key components of net primary production (NPP: wood, fine roots, and leaves) and autotrophic respiration (R_a; wood, rhizosphere, and leaf respiration). We found that lower fertility sites were less efficient at producing biomass and had higher rhizosphere respiration, …

Organ-Specific Regulation Of Atp7a Abundance Is Coordinated With Systemic Copper Homeostasis, Haarin Chun, Tracy Catterson, Heejeong Kim, Jaekwon Lee, Byung-Eun Kim

Department of Biochemistry: Faculty Publications

Copper (Cu) is an essential cofactor for various enzymatic activities including mitochondrial electron transport, iron mobilization, and peptide hormone maturation. Consequently, Cu dysregulation is associated with fatal neonatal disease, liver and cardiac dysfunction, and anemia. While the Cu transporter ATP7A plays a major role in both intestinal Cu mobilization to the periphery and prevention of Cu over-accumulation, it is unclear how regulation of ATP7A contributes to Cu homeostasis in response to systemic Cu fluctuation. Here we show, using Cu-deficient mouse models, that steadystate levels of ATP7A are lower in peripheral tissues (including the heart, spleen, and liver) under Cu deficiency …

Lingnan Gardeners Newsletter (No. 33) = 嶺南彩園通訊 (第33期), Lingnan Gardeners, Kwan Fong Cultural Research And Development Programme, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

Flowers of Dragon Fruit 火龍果花

Desert Pool {If Every Desert Was Once A Sea}, Karen Miranda Abel

The Goose

Desert Pool {If every desert was once a sea} is a site-specific art project by Canadian artist Karen Miranda Abel completed in 2016 while artist-in-residence at Joya: arte + ecología, an arts-led research centre situated in an alpine desert within a national park in southern Spain. The elemental installation represents an envisioning of the ancient sea that occupied the Sierra de María-Los Vélez Natural Park millions of years before the current desert ecology, a time when its highest mountain peaks may have been islands.