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2021 School Of Culinary Arts And Food Technology, Spring Newsletter, Tu Dublin., James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Spring Newsletter captured the many events, research, awards, significant contributions and special civic and community activities which the students and staff members of the school have successfully completed up to the Spring period of 2021. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters. In this issue we also fondly remember Cathal Brugha Street, Dublin 2 (as the school now prepares to move to our new campus facilities …

The Dna Cloud: Is It Alive?, Theodoros Bargiotas

LSU Doctoral Dissertations

In this analysis, I will firstly be presenting the current knowledge concerning the materiality of the internet based Cloud, which I will henceforth be referring to as simply the Cloud. For organisation purposes I have created two umbrella categories under which I place the ongoing research in the field. Scholars have been addressing the issue of Cloud materiality through broadly two prisms: sociological materiality and geopolitical materiality. The literature of course deals with the intricacies of the Cloud based on its present ferromagnetic storage functionality. However, developments in synthetic biology have caused private tech companies and University spin-offs to flirt …

Pirnas As Modulators Of Disease Pathogenesis, Kayla J. Rayford, Ayorinde Cooley, Jelonia T. Rumph, Ashutosh Arun, Girish Rachakonda, Fernando Villalta, Maria F. Lima, Siddharth Pratap, Smita Misra, Pius N. Nde

Publications and Research

Advances in understanding disease pathogenesis correlates to modifications in gene expression within different tissues and organ systems. In depth knowledge about the dysregulation of gene expression profiles is fundamental to fully uncover mechanisms in disease development and changes in host homeostasis. The body of knowledge surrounding mammalian regulatory elements, specifically regulators of chromatin structure, transcriptional and translational activation, has considerably surged within the past decade. A set of key regulators whose function still needs to be fully elucidated are small non-coding RNAs (sncRNAs). Due to their broad range of unfolding functions in the regulation of gene expression during transcription and …

Macrophage And Adipocyte Interaction As A Source Of Inflammation In Kidney Disease, Cristina Martos-Rus, Goni Katz-Greenberg, Zhao Lin, Eurico Serrano, Diana Whitaker Menezes, Marina Domingo-Vidal, Megan Roche, Kavitha Ramaswamy, D. Craig Hooper, Bonita Falkner, Maria P Martinez Cantarin

Kimmel Cancer Center Faculty Papers

In obesity, adipose tissue derived inflammation is associated with unfavorable metabolic consequences. Uremic inflammation is prevalent and contributes to detrimental outcomes. However, the contribution of adipose tissue inflammation in uremia has not been characterized. We studied the contribution of adipose tissue to uremic inflammation in-vitro, in-vivo and in human samples. Exposure to uremic serum resulted in activation of inflammatory pathways including NFκB and HIF1, upregulation of inflammatory cytokines/chemokines and catabolism with lipolysis, and lactate production. Also, co-culture of adipocytes with macrophages primed by uremic serum resulted in higher inflammatory cytokine expression than adipocytes exposed only to uremic serum. Adipose tissue …

[(Wr)8Wkβa]-Doxorubicin Conjugate: A Delivery System To Overcome Multi-Drug Resistance Against Doxorubicin, Khalid Zoghebi, Hamidreza Montazeri Aliabadi, Rakesh Kumar Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application. We have previously shown that cyclic peptide [WR]₉ containing alternate tryptophan (W) and arginine (R) residues acts as an efficient molecular transporter. An amphiphilic cyclic peptide containing a lysine (K) residue and alternative W and R was conjugated through a free side chain amino group with Dox via a glutarate linker to afford [(WR)₈WKβA]-Dox conjugate. Antiproliferative assays were performed in different cancer cell lines using the conjugate and the …

Gas Measurement Device, Megan C. Frost, Weilue He

Michigan Tech Patents

A device including a first chamber, a second chamber, and a membrane permeable to neutral gases but impermeable to water that is positioned between the first chamber and the second chamber. The membrane includes a first layer including PVDF and PDMS, and the PVDF has a plurality of pores at least partially filled with at least some of the PDMS.

Targeting Epigenetic Mechanisms In Endometriosis, Sarah Elizabeth Brunty

Theses, Dissertations and Capstones

Endometriosis is a complex and elusive gynecological disease in which the inner lining of the uterus grows in locations outside of the uterus and forms lesions. It is known to affect 1 in 9 women of reproductive age worldwide. Symptoms of endometriosis include severe pain, heavy periods, and infertility. While multiple theories of origin exist, none fully encompass all aspects of the disease, although all theories agree that this is an inflammation-driven disease. Due to this, many researchers are turning towards epigenetics to explain the initiation and progression of endometriosis. However, what is causing these epigenetic changes is still a …

Tolle Lege Works Published In 2021, Mcquade Library

Bibliographies

Compiled Tolle Lege bibliography of works published by members of the Merrimack College Community in 2021. Works include journal articles, books, book chapters, conference presentations and posters, and more.

The Gut Microbiome And Substance Use Disorder., Jordan T Russell, Yanjiao Zhou, George M. Weinstock, Jason A. Bubier

Faculty Research 2021

Substance use disorders (SUDs) remain a significant public health challenge, affecting tens of millions of individuals worldwide each year. Often comorbid with other psychiatric disorders, SUD can be poly-drug and involve several different substances including cocaine, opiates, nicotine, and alcohol. SUD has a strong genetic component. Much of SUD research has focused on the neurologic and genetic facets of consumption behavior. There is now interest in the role of the gut microbiome in the pathogenesis of SUD. In this review, we summarize current animal and clinical evidence that the gut microbiome is involved in SUD, then address the underlying mechanisms …

The Role Of Nutrient Availability In Therapeutic Response Of Leukemia, Rohiverth Guarecuco Jr.

Student Theses and Dissertations

Tumor environment influences the response to anti-cancer therapy, but which extracellular nutrients impact drug sensitivity is largely unknown. In this work, we used functional genomics to identify metabolic modifiers of the response to L-asparaginase (ASNase), a therapy that depletes plasma asparagine and targets leukemic cells with insufficient asparagine synthesis. Our approach revealed thiamine pyrophosphate kinase 1 (TPK1), which converts vitamin B1 (thiamine) into the cofactor thiamine pyrophosphate (TPP), as a metabolic dependency under ASNase treatment. In glutamine-anaplerotic leukemia cells, we found that TPP availability enables asparagine synthesis from extracellular glutamine. Mechanistically, TPP is critical for the activity of alpha-ketoglutarate dehydrogenase …

A Translational Approach To Modeling Unique Aspects Of Germ Cell Development During Self-Organization Of The Primate Embryo, Rohan R. Soman

Student Theses and Dissertations

The specification of germ cells during embryonic development is vital not only for the development of an organism, but quite literally for the survival and propagation of its entire species. Recent work has demonstrated that several aspects of human primordial germ cell (hPGC) development are specific to primates, necessitating model systems and in vivo validation that is also species specific. In this work, a synthesis of in vitro and in vivo techniques is used to investigate hPGC specification within a human embryonic stem cell model of a gastrulating embryo known as a gastruloid. An hPGC transcriptomic signature that indicates migratory …

Long Non-Coding Rna Meg3 Deficiency Impairs Glucose Homeostasis And Insulin Signaling By Inducing Cellular Senescence Of Hepatic Endothelium In Obesity, Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, Xinghui Sun

Department of Biochemistry: Faculty Publications

Obesity-induced insulin resistance is a risk factor for diabetes and cardiovascular disease. However, the mechanisms underlying endothelial senescence in obesity, and how it impacts obesity-induced insulin resistance remain incompletely understood. In this study, transcriptome analysis revealed that the long non-coding RNA (lncRNA) Maternally expressed gene 3 (Meg3) is one of the top differentially expressed lncRNAs in the vascular endothelium in diet-induced obese mice. Meg3 knockdown induces cellular senescence of endothelial cells characterized by increased senescence-associated β–galactosidase activity, increased levels of endogenous superoxide, impaired mitochondrial structure and function, and impaired autophagy. Moreover, Meg3 knockdown causes cellular senescence of hepatic endothelium in …

The First Report About Genetic Diversity Analysis Among Endemic Wild Rhubarb(Rheum Ribes L.) Populations Through Ipbs Markers, Çeknas Erdi̇nç, Ayteki̇n Eki̇nci̇alp, Si̇bel Turan, Meti̇n Koçak, Faheem Shahzad Baloch, Suat Şensoy

Turkish Journal of Agriculture and Forestry

Approximately 30% of plant species of Turkey, which is among the richest countries in terms of biodiversity, has been endemic. Wild rhubarb (Rheum ribes L.) is a wild vegetable grows especially in the eastern region of Turkey and is an endemic species. In this study, genetic relationships among 80 wild rhubarb genotypes collected from some regions of Lake Van Basin, which are in the distribution area, were tried to be determined by iPBS marker system. At the same time, a commercial variety of R. rhabarbarum, which is a cultivated species, was used as control. PCR studies were conducted with 23 …

Arabinoxylan Structural Profiling Of Cool-Season Pasture Grasses Via High-Performance Anion-Exchange Chromatography With Pulsed Amperometric Detection (Hpaec-Pad) Analysis Of Endoxylanase Digests, Glenna Erin Joyce

Theses and Dissertations--Animal and Food Sciences

Arabinoxylan (AX) is a major structural polysaccharide found in the cell walls of monocots such as cereal grains and pasture grasses. The variety of AX structural components and substitution patterns contribute to AX structural diversity between different monocot species as well as plant tissues.

The rumen is the first digestion site of masticated food material in cattle and provides 70% of energy to host through fermentation of forage. There are many species of pasture grasses that act as a forage source. Differences in AX structure found in these pasture grasses may impact rumen microbial fermentation. Understanding the AX structure of …

Culture Media And Growth Regulators Influence Callus Induction And Plant Regeneration Of Mature Embryos Of Orchardgrass (Dactylis Glomerata L.), Selçuk Kodaz, Kami̇l Hali̇loğlu, Arash Hossein Pour, Murat Aydin

Turkish Journal of Agriculture and Forestry

To establish an efficient in vitro regeneration protocol for orchardgrass (Dactylis glomerata L.), type of medium, several plant growth regulators and their various concentrations were evaluated in a factorial experiment for callus induction and plant regeneration. Endosperm supported mature embryo were used as explants and optimum response in callus induction was observed on Chu medium with 12 mg/L dicamba (3.6-dichloro-2-methoxybenzoic acid). The highest responding embryogenic callus (15%) was found with Murashige and Skoog medium and 8 mg/L 2.4-D (2,4-dichlorophenoxy acetic acid). The highest regeneration efficiency was achieved on MS medium (17 plantlets) with 8 mg/L 2,4-D. Endosperm-supported mature embryos of …

Trapping, Identification And Rearing Of Edible Palm Weevils In Kenya And Uganda, J. P. Egonyu, K. J. Gitonga, F. M. Khamis, R. S. Copeland, P. Finyange, R. Odhiambo, G. Ddamulira, C. M. Tanga, S. Subramanian

All Peer-Reviewed Publications

Palm weevils, Rhynchophorus spp. (Coleoptera: Curculionidae) double as devastating invasive pests of palms, and delicacies in many communities. This study evaluated ethyl acetate and 3-methyl-octan-4-ol for trapping palm weevils from coconut, oil and raffia palms in Kenya and Uganda; taking into account the distance of traps on oil palm from a forest or raffia palm. Eggs from the weevils from different locations were incubated and their larvae reared on sugarcane under laboratory conditions. All the 285 weevils collected were identified by morphological and molecular techniques as Rhynchophorus phoenicis, and the catch was female-biased. 3-methyl-octan-4-ol attracted more weevils than ethyl acetate. …

Lingnan Gardeners Newsletter (No. 53) = 彩園通訊 (第53期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

No abstract provided.

Metabolite Profiling, Distribution Of Secretory Structures, And Histochemistry Incurculigo Orchioides Gaertn. And Curculigo Latifolia Dryand. Ex W.T.Aiton, Abdul Halim Umar, Diah Ratnadewi, Mohamad Rafi, Yohana C. Sulistyaningsih, Hamim Hamim

Turkish Journal of Botany

Curculigo orchioides and Curculigo latifolia (Hypoxidaceae) have been widely used as traditional medicines in Indonesia and other Asian countries for antihyperglycemic, aphrodisiac, antioxidant, and antimicrobial treatments. This work aimed to determine the distribution of secretory structures and metabolites. Metabolite profiling approach of the plant organs was determined by UHPLC-QOrbitrap-HRMS. Histochemical-based techniques on rhizome, root, petiole, and leaf, with transversal sections on fresh samples, were prepared using a razor blade to determine the secretory structures of the plants, followed by plant anatomy procedures. Histochemical analysis was carried out using several reagents to detect the metabolites. Metabolite profiling revealed several classes of …

Alfred Russel Wallace Notes 15. Wallace's Many "Hats": What Should We Call Him?, Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) has been referred to by name through the aid of a variety of labels – some thirty or more, in fact – that link him to his emphases of attention. How many of these labels are/were justifiable? The assessment here is that he is probably best remembered as a ‘naturalist,’ ‘geographer,’ ‘evolutionist,’ and ‘social critic.’

A Rich Fading Biocultural Diversity?A Review Of Traditional Herbal Teas Used By Minorities In The Balkans, Muhammad Abdul Aziz, Andrea Pieroni, Syed Abidullah, Anely Nedelcheva

Turkish Journal of Botany

Ethnobotanical studies focusing on medicinal plant ingredients have always been conducted with the aim of protecting the local ecological knowledge (LEK) of these natural resources. In the globalized world, the rapid loss of biodiversity and cultural and linguistic homogenization have threatened the survival of the planet, together with leading us towards an extinction crisis. In this extreme situation, LEK is also facing serious challenges, especially that of minorities where the pressure is manifold. A number of studies have been carried out among minority groups in recent times, and scientists are attempting to devise solid policy recommendations to celebrate their LEK …

An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk

Turkish Journal of Biology

Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B 1.351, P.1, and B.1.617 lineages or variants of …

The Role Of Glt-1 Signaling In Oligodendrocytes During Development And Myelin Repair, Elizabeth Thomason

Theses and Dissertations

The differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating oligodendrocytes (OLGs) requires an increase in the complexity of process morphology, alterations in membrane trafficking, and the production of myelin proteins. Branching and process extension have already been shown to follow glutamate signaling through OLG-expressed excitatory amino acid transporters (EAATs), mostly via GLT-1. It is of note that glutamate homeostasis often goes awry in multiple sclerosis (MS), the main demyelinating disease in humans. Thus, we have sought to gain an understanding of the role that GLT-1 plays under the myelination and remyelination conditions that arise during natural development of OLGs and …

Screening Of The Small Molecule Library Of Meinox Enables The Identification Of Anticancer Compounds In Pathologically Distinct Cancers, Aynura Mammadova, Ari̇f Mermer, Fati̇h Kocabaş

Turkish Journal of Biology

Small molecules are widely used for the modulation of the molecular basis of diseases. This makes them the perfect tool for discovering and developing new therapeutics. In this work, we have established a library of small molecules in house and characterized its molecular and druglike properties. We have shown that most small molecules have molecular weights less than 450. They have pharmaceutically relevant cLogP, cLogS, and druglikeness value distributions. In addition, Meinox's small molecule library contained small molecules with polar surface areas that are less than 60 square angstroms, suggesting their potent ability to cross the blood-brain barrier. Meinox's small …

Identifying Specific Matrix Metalloproteinase-2-Inhibiting Peptides Through Phage Display-Based Subtractive Screening, Ayli̇n Özdemi̇r Bahadir, Bertan Koray Balcioğlu, Müge Serhatli, Şeyma Işik, Berri̇n Erdağ

Turkish Journal of Biology

Gelatinases A and B, which are members of the matrix metalloproteinase (MMP) family, play essential roles in cancer development and metastasis, as they can break down basal membranes. Therefore, the determination and inhibition of gelatinases is essential for cancer treatment. Peptides that can specifically block each gelatinase may, therefore, be useful for cancer treatment. In this study, subtractive panning was carried out using a 12-mer peptide library to identify peptides that block gelatinase A activity (MMP-2), which is a key pharmacological target. Using this method, 17 unique peptide sequences were determined. MMP-2 inhibition by these peptides was evaluated through zymogram …

Social Comparison Tendencies And The Reward Value Of Same-Sex Beauty Among Heterosexual Women, Melissa M. Martin Ms.

Cal Poly Humboldt theses and projects

Previous studies have suggested that heterosexual women, but not heterosexual men, find same sex beauty rewarding. This finding has been attributed to a “greater bisexual interest among heterosexual women”, but no other explanations have been offered or tested. The current study aimed to explore social comparison tendencies as a potential alternate explanation to this previously observed finding. Twenty-three heterosexual women completed a series of questionnaires designed to assess their social comparison tendencies (the social comparison orientation scale, the physical appearance comparison scale, and the intrasexual competition scale). They also completed a “pay-per-view” keypress task to measure the reward value of …

An Overview Of Antimicrobial Compounds From African Edible Insects And Their Associated Microbiota, Cynthia M. Mudalungu, Chrysantus M. Tanga, Segenet Kelemu, Baldwyn Torto

All Peer-Reviewed Publications

The need for easily biodegradable and less toxic chemicals in drug development and pest control continues to fuel the exploration and discovery of new natural molecules. Like certain plants, some insects can also respond rapidly to microbial infections by producing a plethora of immune-induced molecules that include antibacterial and antifungal peptides/polypeptides (AMPs), among other structurally diverse small molecules. The recent recognition that new natural product-derived scaffolds are urgently needed to tackle life-threatening pathogenic infections has been prompted by the health threats posed by multidrug resistance. Although many researchers have concentrated on the discovery of AMPs, surprisingly, edible insect-produced AMPs/small molecules …

Cannibalism, Oviposition And Egg Development In The Edible Long-Horned Grasshopper, Ruspolia Differens (Orthoptera: Tettigoniidae) Under Laboratory Conditions, J. P. Egonyu, M. M. Miti, C. M. Tanga, A. Leonard, S. Subramanian

All Peer-Reviewed Publications

Reliance on seasonal wild harvests of the edible long-horned grasshopper Ruspolia differens (Serville) (Orthoptera: Tettigoniidae) needs to be broken through developing efficient mass rearing protocols. This study aimed at boosting productivity of laboratory colonies of R. differens through understanding ways of minimising cannibalism, selecting suitable oviposition substrates and enhancing egg development and hatchability. Firstly, we investigated the extent of cannibalism in a colony of R. differens relative to total mortality, sex, diurnality, growth stage, body parts eaten and visual barriers (presence/absence of cardboard egg trays). R. differens cadavers recovered from cages with/without the egg trays were scored for cause of …

Impact Of Endangered Animal Protection Rights, Policies, And Practices On Zoonotic Disease Spread, Daniella Fedak-Lengel

Honors Projects

Building on field research in Costa Rica and Belize, this honors project analyzes environmental and endangered animal protection policies, rights, and practices in Central America and the Caribbean, and assesses the impact of veterinary science and biological research and practice, particularly conservation biology, on animal welfare concerns. Informed by the recent surge in awareness regarding zoonoses and zoonotic disease transmission, prevention and control, resulting from the current global pandemic of SARS-CoV-2, the project assesses the need for new and innovative types of collaboration, particularly involving conservation biologists, environmental scientists, public health experts, law and policy makers, and global trade and …

The 2019 P-Mig Student Survey Report And Capturing The Undergraduate Perspective Of Physiology Programming, Jennifer Rogers, Jenny L. Mcfarland, Claudia I. Stanescu, Patrick L. Crosswhite, Anne R. Crecelius

Health and Sport Science Faculty Publications

The aim of the 2019 Student Survey was to inform the Physiology Majors Interest Group (PMIG) of characteristics of undergraduates enrolled in physiology courses or degree programs from across the United States, to be used as one input source for development of program-level guidelines. 1389 participants from seven universities completed the 2019 P-MIG Student Survey. 37% reported enrollment in a physiology/human physiology major; allied health related programs were the second most common (24%). 61% of respondents reported attending a community college, the majority of whom enrolled in one or more courses at a community college while in high school (44%). …

Anti-Inflammatory Properties Of Blackberry Phenolic And Volatile Compounds, Pauline Morin

Graduate Theses and Dissertations

Berries are known for many health benefits including anti-inflammatory properties that lower risks of chronic diseases. These properties have been linked to high concentrations of phenolic compounds, especially anthocyanins. However, the present study hypothesized that volatiles could contribute to the berries’ bioactive properties. Thus, the objectives of this research are to profile the phenolic and volatile composition of 16 blackberry genotypes harvested at the Fruit Research Center of the University of Arkansas and to evaluate the antiinflammatory capacities of three selected genotypes on inflamed cells. Phenolic and volatile profiles were evaluated using chromatographic techniques. The three genotypes A2528T, A2587T and …