Digital Commons Network^™

Evaluation Of Host Resistance To Rotylenchulus Reniformis In Sweetpotato Germplasm, Timothy S. Miller

LSU Master's Theses

The reniform nematode (Rotylenchulus reniformis) is an emerging plant-parasitic threat to sweetpotato production. Dissimilar from the galling caused by root-knot nematode infections, infections from the reniform nematode occur without visible damage to the root system. In the southern United States, heavily infested sweetpotato fields can lose up to 40% of their total yield. Growers rely heavily on fumigants and nematicides which provide inconsistent control and are not sustainable in the long-term. Past research has been more focused on the efficacy of chemicals than in the identification of host resistance or tolerance in sweetpotato germplasm. This study evaluated past …

Oxygen Supply Capacity Of The Atlantic Horseshoe Crab,, Marty Sims

USF Tampa Graduate Theses and Dissertations

The horseshoe crab, Limulus polyphemus, inhabits shallow bays and estuaries where it encounters variable oxygen levels. Moreover, each year, the biomedical industry harvests hemolymph from hundreds of thousands of horseshoe crabs to use in bacterial contamination testing, yet the effects of bloodletting on their physiology are relatively unknown. This study aims to determine the oxygen supply capacity of Limulus polyphemus in relation to environmental hypoxia and biomedical bloodletting. Study animals were collected from the intertidal waters of Tampa Bay, Florida. Experiments included a control group that did not undergo substantial blood-volume reduction and a treatment group from which 10% of …

The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill

Biology Faculty Publications

The genome of the hemlock woolly adelgid (Adelges tsugae) is presented in 10 chromosomal pseudomolecules along with 132 unplaced scaffolds for a combined length of 216.56 Mb. The genome is highly contiguous with an N50 of 20.54 Mb and its longest scaffold 37.41 Mb in length. The assembly recovered 97.7% of benchmarked universal single-copy Hemiptera orthologs (BUSCO) with an overall completion score of 98.6%. On the basis of chromosomal synteny with other aphid genomes, the hemlock woolly adelgid’s genome is composed of eight autosomes and two sex (X) chromosomes. Annotation of the assembly identified 11,800 coding genes, 1,930 …

Perceived Recovery And Muscle Fatigue In Professional Soccer Players During Preseason, Josip Maleš, Frane Žuvela, Nicola Bragazzi, Andrea De Giorgio, Goran Kuvačić

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1212-1227, 2025. https://doi.org/10.70252/ERIN2946 This study aimed to examine weekly variations and within-subject relationships between internal training intensity (ITI), perceived recovery (TQR), neuromuscular performance (CMJ), and perceived muscle soreness (PMS) during a four-week preseason period in professional soccer players. Twenty-three soccer players (age 24.8 ± 4.4 years; height 182 ± 7 cm; body mass 74.6 ± 6.7 kg) classified as Tier 3 athletes from the Croatian Second Soccer League were monitored using session rating of perceived exertion, TQR scales, countermovement jump tests, and PMS questionnaires. A significant reduction in ITI and concurrent improvement in TQR …

Effects Of A Quadricep-Dominant Vs. Functional Training Program On Activities Of Daily Living, Functional Performance, And Motor Unit Recruitment In Older Adults, Brittany Followay, Tamera Holland, Larissa Rowley

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1096-1113, 2025. https://doi.org/10.70252/YHYC9630 The study investigated the effects of a quadriceps-dominant (QD) versus functional (FX) training program on the Functional Movement Screen (FMS), activities of daily living (ADLs), and motor unit (MU) recruitment of the vastus lateralis (VL) and biceps femoris (BF). Twenty-six older adults (68.9 + 5.1yrs) were randomly assigned to a 6-week QD or FX training program. Participants completed ADLs, FMS, and three closed-kinetic chain exercises (CKCs): front lunge (FL), side lunge (SL), and bilateral squat (BLSQ), pre and post-intervention. Electromyography was recorded from the VL and BF during maximal voluntary isometric …

Where Is The Power In A Power Analysis?, Kevin D. Dames, Zoe Climenhaga, Jared Rosenberg

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 1114-1120, 2025. https://doi.org/10.70252/AVGK2063 Strategic planning of research involves predicting the number of replications of the experiment needed to detect an expected effect. The power analysis to determine sample size for the proposed experiment requires known or estimated characteristics of existing distributions. When used well, power analysis reduces the risk of statistical errors, wasted efforts, and temptations to twist ensuing analyses to eke out a ‘significant’ result after data collections conclude. This editorial highlights some examples of how this process goes awry. Sections are dedicated to the role of researchers, the case for ‘pilot’ studies, …

Hemodynamic And Autonomic Modulation In Response To Additive Sympathetic Stressors In Young, Healthy Individuals, J. Derek Kingsley, Anthony G. Pinzone, Gretchen E. Elsey, Stacie M. Humm

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1047-1060, 2025. https://doi.org/10.70252/WWDK4926 Isometric handgrip (IHG) coupled with post-exercise muscular ischemia (PEMI) and the cold pressor test (CPT) have been demonstrated to increase measures of hemodynamics and to reduce vagal tone. However, little is known about how acute resistance exercise (RE) alters these responses. The purpose was to evaluate an acute bout of RE in conjunction with a single- or dual-stressor task on hemodynamics and autonomic modulation in resistance-trained individuals. Ten resistance-trained individuals (Mean ± SD; Age: 23 ± 3 years) completed a single- (SS: IHG + PEMI only) or dual-stressor (DS: IHG + …

The Effect Of Ankle Bracing On Athletic Performance Variables In Healthy Young Adult Athletes, Penny L. Head, Kurt Neelly, Karen Furgal, Sydney Graves, Meredith Jordan, Mackenzie Polston, Zach Powars, Hailey Shuttleworth, Daniel Smalling

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 1086-1095, 2025. https://doi.org/10.70252/XPTX6116 Acute ankle sprains are common in sports and carry a significantly increased risk of recurrence after an initial injury. Bracing has been shown to reduce injury recurrence; however, athletes may decline this prophylactic measure due to fear of negative effect on athletic performance. Previous research examining the impact of bracing on performance has demonstrated conflicting results. The purpose of this study was to examine the effect of bracing on choice reaction time and foot speed in healthy, young adults using computerized agility testing. Twenty-eight healthy athletes aged 18-25 years completed the …

Effect Of Velocity-Based Training On Vertical Jump Performance By Beach Volleyball Players, Filipe Aquino, Igor Nasser, Wladymir Külkamp, Bruno Ribeiro Ramalho Oliveira, Diego Viana Gomes, Everton Crivoi Do Carmo, Walace Monteiro, Eduardo Latari

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1061-1071, 2025. https://doi.org/10.70252/DFMZ2015 The aim of this study was to examine variations in countermovement jump (CMJ) performance after two velocity-based training (VBT) protocols in the half-squat exercise. Sixteen male beach volleyball athletes performed CMJ tests before and after three experimental sessions on the half-squat exercise. The two VBT protocols were performed in three sets, at a mean propulsive velocity (~ 0.49 m•s⁻¹) associated with relative intensity (~ 85% 1RM), with three minutes interset recovery. In the VL0-10 session, the participants stopped their sets upon reaching a velocity loss (VL) threshold of 10%. …

Renoprotective Potential Of Ciprofloxacin, Prednisolone, And Infliximab In Acetic Acid-Induced Ulcerative Colitis Rats, O. A. Oyesola, O. E. Olayemi, B. I. Kukoyi

AUIQ Complementary Biological System

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with systemic manifestations, including renal impairment mediated by oxidative stress, inflammation, and electrolyte imbalance. This study investigated the renoprotective potential of ciprofloxacin, prednisolone, and infliximab in rats with acetic acid–induced UC. Fifty male Sprague–Dawley rats (180–200 g) were divided into five groups (n = 10): control, UC control, UC + ciprofloxacin (50 mg/kg, p.o.), UC + prednisolone (4 mg/kg, p.o.), and UC + infliximab (5 mg/kg, i.p.). UC was induced by rectal instillation of 4% acetic acid, and treatments were administered for 42 days. Serum urea, creatinine, electrolytes, and malondialdehyde (MDA) …

Goals Reconsidered: From Brute Prelusory States Of Affairs To The Lusory Complexity Of Sport, Francisco Javier López Frías

Kinesiology and Health Science Faculty Publications

In this paper, I examine Bernard Suits’ conceptualization of goals in his influential definition of gameplay, focusing on how his account falls short of capturing the complexity of sporting practices. Suits famously describes games as voluntary attempts to overcome unnecessary obstacles in achieving an identifiable state of affairs. By referring to this state of affairs as the prelusory goal of games, he frames gameplay as structured teleologically around this goal, converting it into the most fundamental element of his notion of gameplay. Although elegant and very intuitive, this conception of games raises tensions when applied to the complex, multilayered activities …

Correlates Of Professional Breastfeeding Perceived Role, Perceived Influence, And Confidence In Providing Lactation Support Among Registered Dietitians And Registered Nurses, Lauren M. Dinour, Melanie Shefchik, Andrea Uguna

Department of Nutrition and Food Studies Scholarship and Creative Works

Lactation support from health professionals is a crucial social determinant of health. Registered dietitians (RDs) and registered nurses (RNs) can play an important role in supporting breastfeeding, yet most have minimal formal lactation education and training. This study seeks to explore the correlates of professional breastfeeding perceived role, perceived influence, and confidence in providing lactation support among RDs and RNs. Using a cross-sectional design, a convenience sample of 111 credentialed providers completed an online survey assessing their breastfeeding-related training, experiences, knowledge, attitudes, and practices. We also examined perceptions of social support, intentions for future breastfeeding, professional roles, and confidence in …

Extraction And Optimization Of Flavonoids From Elaeagnus Pungens Thunb And Its Potential Impact On Blood Plasma Cholesterol In A Mouse Model, Qunqing Lu, Haozhe Liu, Xinxin Zhang, Nourhan Nassar, Ibrar Khan, Haji Gul, Zaigui Wang

The Thai Journal of Veterinary Medicine

Elaeagnus pungens Thunb is a significant source of flavonoids with biological function. This study aims to develop orthogonal tests and alkali alcohol extraction methods for extracting flavonoids from leaves of E. pungens. The levels of factors in the orthogonal test were determined by pre-experiment, and the physiological efficacy was verified by the in vivo test. The results indicated that the optimal extraction yield was 4.07% when the solid-to-liquid ratio was 1:40, the concentration of ethanol was 60%, the extraction temperature was 80℃, and the extraction time was five h. The alkalialcohol extraction results demonstrated that the extraction yield of …

Dietary Patterns For Weight And Glycemic Management In Persons With Type 1 Diabetes: A Meta-Analysis Of Clinical Trials, Daria Igudesman, Laura M Nally, Alyssa A Grimshaw, Craig G Gunderson, Elizabeth G Considine, Laura M Jacobsen, Mustafa Tosur, Peter A Gottlieb, Irl B Hirsch, Lori M Laffel, Jennifer L Sherr, Chantal Mathieu, Richard E Pratley

Children’s Nutrition Research Center Staff Publications

Background: Medical nutrition therapy is fundamental for managing glycemia and weight in type 1 diabetes, yet dietary guidance specific to this population and relevant subgroups is lacking.

Purpose: We synthesized the interventional literature investigating diet patterns for glycemic and weight management in youth and adults with type 1 diabetes, with attention to interindividual variation that suggests the need for precision approaches. The protocol was prospectively registered (CRD42024519941).

Data sources: AMED, CINAHL, Cochrane Library, Ovid MEDLINE, Ovid Embase, Google Scholar, and Web of Science Core Collection were searched from January 2011 to June 2024.

Study selection: Clinical trials ≥4 weeks with …

Design Of A Snp Panel For Highly Accurate Paternity Identification In Eşme Sheep, Onur Yilmaz, İbrahi̇m Cemal, Orhan Karaca, Cengi̇z Elmaci, Nezi̇h Ata

Turkish Journal of Veterinary & Animal Sciences

SNP paternity testing panels offer high-resolution capabilities for determining livestock paternity, thereby enhancing the reliability of genetic verification and ensuring pedigree record accuracy. In this study, we aimed to develop a SNP-based paternity test panel utilizing a 50K SNP chip for paternity testing and pedigree verification in the Eşme sheep breed. Additionally, the study sought to validate the paternity test panel. Based on data from 26 rams and 524 lambs of the Eşme sheep breed, the results indicated that the 50K SNP chip used demonstrated a very high genotyping rate, with the majority of its 53,738 SNPs exhibiting significant polymorphism. …

Development And Validation Of A High-Performance Liquid Chromatography Method For The Simultaneous Determination Of Selected Varroacidal Active Substances In Bee Health Products, Onur Demi̇r

Turkish Journal of Veterinary & Animal Sciences

The presence of substandard and counterfeit veterinary medicinal products represents a significant concern from a One Health perspective, given the potential consequences for human and animal health, as well as the environment. In this study, an isocratic flow liquid chromatography method was developed for the simultaneous determination of thymol, coumaphos, amitraz, tau-fluvalinate, and flumethrin in bee health products used for varroosis control. The chromatographic separation was conducted at a wavelength of 276 nm, utilizing an RP18e column and an acetonitrile:water mobile phase ratio of 75:25 (v/v), with a flow rate of 0.75 mL/min. The validation of the method was conducted …

Evaluating The Impact Of Starch Intake On Fecal Consistency Scores In Equines, Gülşah Kaya Karasu, Hidir Gümüş

Turkish Journal of Veterinary & Animal Sciences

Horses, as monogastric hindgut fermenters, primarily engage in microbial activity in the large intestine. Although starch is not inherently harmful, excessive intake can lead to digestive disturbances and health issues due to insufficient digestion in the small intestine, resulting in overflow into the large intestine. The purpose of the study was to evaluate the use of rapid fecal analysis, including fecal score, pH, and dry matter (DM) analysis, to understand the effects of high starch intake. The study was conducted in May 2023 at a private sport horse farm in İzmir, Türkiye and involved 24 sport horses aged 4 to …

Implementation Evaluation Of Blood Flow Restriction In The Rehabilitative Setting, Corbit Franks, Madison Wellborn, Matthew A. Chatlaong, Daphney M. Carter, William M. Miller, Matthew B. Jessee, Robert E. Davis

Internet Journal of Allied Health Sciences and Practice

Purpose: Blood flow restriction refers to a training/rehabilitation method consisting of an external pressure system applied to a limb to partially inhibit blood flow to the tissues. Though much research has been conducted concerning the use of blood flow restriction, there is limited research concerning why clinicians may or may not utilize it. Objective: The current qualitative study utilized the Consolidated Framework for Implementation Research to investigate why clinicians may or may not implement blood flow restriction in the clinical setting. Methods: A semi-structured interview addressing twelve implementation constructs within four domains (Intervention Characteristics, Outer Setting, Inner Setting, and Characteristics …

A Case Series: Effectiveness Of Nintendo Ring Fit In Improving Balance And Stability Deficits After Recovery From Acl Reconstruction, Emma C. Lord, Melissa A. Tolbert, Whitley J. Stone

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 10, 2025. This study aimed to assess the effectiveness of a gaming system in improving balance, strength, and power after recovery from an anterior cruciate ligament reconstruction (ACLR). Existing bilateral deficits were also assessed among patients.

Four participants between the ages of 18-24 years were recruited for this case-control study. Participants must have had an ACLR in the last 2 years, been discharged from formal physical therapy, and have a continued history of participating in physical activity at least three times a week. Participants were assigned to either the …

If We Tear It Down, We Might Build You A New One: The Troublesome Use Of Eminent Domain And Urban Neighborhood Swimming Pools, Steven N. Waller Ph.D., James H. Bemiller

International Journal of Aquatic Research and Education

Public swimming pools are a vital part of America’s recreation and sport culture since the early 1900’s. Municipal swimming pools were initially built to provide recreation and hygiene to urban communities, regardless of race or class. However, a complex history of segregation, civil unrest, suburbanization, and funding challenges has resulted in a significant decline in public pools, depriving many communities of vital recreational spaces. In many communities, options for sustaining the operation of swimming pools have resulted in pool closures. Unfortunately, once swimming pools close, especially those in aging neighborhoods in central city areas, they are seldom resurrected. They quickly …

Adopting Stuart Hall’S “Race, The Floating Signifier” As A Conceptual Framework Within Aquatic Research And Education, Kurt J. Cordice

International Journal of Aquatic Research and Education

During his 1997 lecture at Goldsmiths College in London, Stuart Hall, renowned for his contributions to sociology and cultural studies, offered his argument that the concept of race functions as a Floating Signifier. In this essay, Stuart Hall’s Race, the Floating Signifier is presented as a strong conceptual framework to support more accurate and effective positioning of race as an important consideration within aquatic research and education. Evidence from a range of disciplines, including historical research, is presented to establish both the importance and challenge of race within aquatic research and education. This evidence is also used to demonstrate …

Introducing Mcodegpt As A Zero-Shot Information Extraction From Clinical Free Text Data Tool For Cancer Research, Kai Zhang, Tongtong Huang, Bradley A Malin, Travis Osterman, Qi Long, Xiaoqian Jiang

Faculty, Staff and Student Publications

Background: The vast amount of natural language clinical notes about patients with cancer presents a challenge for efficient information extraction, standardization, and structuring. Traditional NLP methods require extensive annotation by domain experts for each type of named entity and necessitate model training, highlighting the need for an efficient and accurate extraction method.

Methods: This study introduces a tool based on the Large Language Model (LLM) for zero-shot information extraction from cancer-related clinical notes into structured data aligned with the minimal Common Oncology Data Elements (mCODE™) structure. We utilize the zero-shot learning capabilities of LLMs for information extraction, eliminating the need …

Understanding Callus Types In Maize By Genetic Mapping And Transcriptional Profiling, Guifang Lin, Yan Liu, Tej Man Tamang, Yang Qin, Mingxia Zhao, Hairong Wei, Et. Al.

Michigan Tech Publications

Plant transformation efficiency is highly dependent on species, individual genotypes, and tissue types. In maize, immature embryos are regularly used for transformation. The process relies heavily on callus development, as it is intricately associated with somatic embryogenesis and subsequent plant regeneration, both of which directly affect transformation efficiency. Immature embryos of the segregation progeny derived from the two inbred parents, a transformation-amenable line A188 and a recalcitrant line B73, can be cultured to form two primary callus types: Type I and Type II. The Type II callus grows faster and is a favorable type for regeneration. Here, Type I and …

Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection, Matthew T Muir, Kyle Noll, Sarah Prinsloo, Hayley Michener, Jeffrey I Traylor, Vinodh A Kumar, Chibawanye I Ene, Sherise Ferguson, Ho-Ling Liu, Jeffrey S Weinberg, Frederick Lang, Brian A Taylor, Stephanie J Forkel, Sujit S Prabhu

Faculty, Staff and Student Publications

When operating on gliomas near critical language regions, surgeons risk either leaving residual tumor or inducing permanent postoperative language deficits (PLDs). Despite the advent of intraoperative mapping techniques, subjective judgments frequently determine important surgical decisions. We aim to inform data-driven surgery by constructing a non-invasive mapping approach that quantitatively predicts the impact of individual surgical decisions on long-term language function. This study included 79 consecutive patients undergoing resection of language-eloquent gliomas. Patients underwent preoperative navigated transcranial magnetic stimulation (TMS) language mapping to identify language-positive sites ("TMS points") and their associated white matter tracts ("TMS tracts") as well as formal language …

Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander

School of Design and Engineering Papers

To combat the growing issue of petroleum plastic waste, alternative bio-based polymers are being developed. Many of these biopolymers are made from bio-derived materials, or are biodegradable, but the most promising polymers fall in both categories. Polyhydroxyalkanoates (PHAs) are one such class of polymers, and poly-3-hydroxybutyrate (P3HB), the most popular PHA, has shown great potential. This study utilized two types of cotton-derived glucose, alongside commercial glucose, as a feedstock for the biosynthesis of P3HB by Cupriavidus necator (also known as Ralstonia eutropha). The fermentation took place in a 2-L bioreactor, showing potential for scale-up. A single-solvent extraction method was …

An Examination Of The Experiences Of An African American Male Diver On A Power Four Swim Team: An Elite Interview, Steven N. Waller Ph.D., Tiffany M. Quash Ph.D.

International Journal of Aquatic Research and Education

Despite the incremental increase in the number of Black people who are learning to swim, the number of Black divers has not kept pace. In the NCAA Database, swimmers and divers were not segmented; thus, they all appear in the category of “swimming” by race and sex. When viewing the 2024 Division I NCAA Demographics Database, 89 (.02%) of 4307 student-athletes participating in swimming were Black women. For men, the data is equally dismal, revealing that 81 (.03%) of 2,608 student-athletes who were identified as swimmers were Black. The purpose of this research note is to examine the developmental experiences …

Efficacy Of Teaching At The Right Level Approach Combined With The Problem-Based Learning Model On Science Learning Outcomes At Middle School, Heri Syahputra Azhar Panjaitan, Ryan Dwi Puspita

Jurnal Pendidikan Sains

This research seeks to evaluate the efficacy of the Teaching at the Right Level (TaRL) strategy in conjunction with the Problem-Based Learning (PBL) model on the scientific learning outcomes of eighth-grade students at middle school Islam Terpadu Khairul Imam. This research addresses the inadequate scientific problem-solving abilities and science learning outcomes of Indonesian students, necessitating a more interactive and individualized instructional technique. The methodology used is a quasi-experimental design with a nonequivalent control group. The sample included two purposively chosen eighth-grade classes: one experimental class (n=25) underwent the TaRL–PBL intervention, whereas the control class (n=25) simply used the lecture approach. …

Managing Chickens From Chicks To Peak Egg Production, Joseph Okoh, Essence Perry

All Current Publications

Chickens were first domesticated for cultural purposes, but selective breeding has focused on egg production. Choosing the right breeds and good management practices are essential for farmers to maximize egg yield, quality, and safety. This fact sheet covers poultry history, top egg-laying breeds, egg anatomy, nutrition, and practical tips to help farmers improve productivity and run successful egg production ventures.

Bridging Bench To Bedside: Developing Sup2-Il-33 Armored Car T Cells For Translational Immunotherapy, Shannon Lynn Ferry

Dartmouth College Ph.D Dissertations

Despite some promising results, CAR T cell therapy elicits limited responses in most patients with solid tumors. Armoring CAR T cells with immunomodulatory cytokines improves efficacy in solid tumors. We previously reported that administering IL-2 superkine (Sup2) and IL-33 cytokine armored CAR T cells without host pre-conditioning is sufficient to broadly activate host immunity to delay growth of B16F10 melanoma in immunocompetent B6 mice. However, lymphodepleting pre-conditioning prior to CAR T cell infusion is routinely utilized to enable engraftment of adoptively transferred cells. Here we assess the efficacy TRP1-specific CAR T cells with or without Sup2 and IL-33 armoring following …

Organism-Specific Sequence Motifs Link Ribosomal Rnas To Brain Disorders, Isidore Rigoutsos, Stepan Nersisyan, Eric Londin, Iliza Nazeraj, Bonnie Dong, Anastasios Vourekas, Phillipe Loher

Computational Medicine Center Faculty Papers

We report that in humans, mice, fruit flies, and worms, the ribosomal RNAs and the transcribed spacers of 45S are densely packed with organism-specific sequence motifs that are primarily shared with nervous system genes. The human ribosomal RNAs and 45S spacers contain 1,723 such motifs. Specific combinations of these motifs are predominantly found in 3,430 human nervous system genes, of which 1,046 are genes associated with brain disorders, including autism spectrum disorder and schizophrenia. The sequences of the 1,723 motifs and their locations in the introns and exons of nervous system genes are unique to primates. Experimental evidence indicates that …