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Rebound Bursting Selectively Enables Fast Dynamics In Dopamine Midbrain Neurons Projecting To The Dorsolateral Striatum, Strahinja Stojanovic, Christopher J. Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin, Stephan Lammel, Carmen C. Canavier, Jochen Roeper Oct 2025

Rebound Bursting Selectively Enables Fast Dynamics In Dopamine Midbrain Neurons Projecting To The Dorsolateral Striatum, Strahinja Stojanovic, Christopher J. Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin, Stephan Lammel, Carmen C. Canavier, Jochen Roeper

School of Graduate Studies Faculty Publications

Dopamine (DA) midbrain neurons are involved in a wide array of key brain functions including movement control and reward-based learning. They are also critical for major brain disorders such as Parkinson's disease or schizophrenia. DA neurons projecting to distinct striatal territories are diverse with regard to their molecular makeup and cellular physiology, which are likely to contribute to the observed differences in temporal DA dynamics. Among these regions, the dorsolateral striatum (DLS) displays the fastest DA dynamics, which might control the moment-to-moment vigor and variability of voluntary movements. However, the underlying mechanisms for these DLS-specific fast DA fluctuations are unresolved. …


How Social, Behavioral, And Policy Factors Impact Water Satisfaction And Management In Urban Areas, Rafi Haikal, Thoriqi Firdaus, Siti Hilya Nabila, Rizqi Shafira Chairunnisa Oct 2025

How Social, Behavioral, And Policy Factors Impact Water Satisfaction And Management In Urban Areas, Rafi Haikal, Thoriqi Firdaus, Siti Hilya Nabila, Rizqi Shafira Chairunnisa

Journal of Environmental Science and Sustainable Development

The issue of water management in Indonesia’s specific urban contexts, specifically in Surabaya as an industrial hub and Bali as a tourist destination, is of paramount importance due to its impact on public health and environmental sustainability. This study analyses water management and conservation factors by comparing two distinct urban areas. The research design employs Partial Least Squares Structural Equation Modelling (PLS-SEM), which involves a specialised approach for analysing the complex relationships between variables. The results of the analysis indicate that community attitudes in Surabaya, facilitated by infrastructure and technology, significantly predicts intention to perform (β=0.334, p<0.001) and water management satisfaction (β=0.409, p<0.001). In contrast, collaboration with the government enhances environmental constraints (β=0.285, p<0.003) and water management satisfaction (β=0.140, p<0.044). In Bali, where water management is based on traditional practices, community attitudes do not significantly affect water management satisfaction (β=0.095, p>0.431). Still, perceived …


Analysis Of Mct-1 Expression In Mouse Neural Retina In Response To Chronic Inflammation, Ian W. Ronson Oct 2025

Analysis Of Mct-1 Expression In Mouse Neural Retina In Response To Chronic Inflammation, Ian W. Ronson

PANDION: The Osprey Journal of Research and Ideas

Chronic inflammation is a current public health concern as it is linked to the etiology and symptoms of numerous diseases, for example diabetic retinopathy (DR). In the case of DR, inflammation leads to dysregulation of the blood retina barrier causing retinal hemorrhage and macular edema leading ultimately to irreversible vision loss. MCT-1 is critical for the survival of photoreceptor cells because MCT-1 forms protein complexes with Basigin, a cell-cell adhesion protein, that enables Müller glial cells to efficiently provide lactate as a high energy fuel source. Previous studies have shown chronic inflammation reduces Basigin expression in the retina and that …


Green Carbon Dots In The Era Of Ai: Sustainable Synthesis, Intelligent Drug Delivery, Advanced Diagnostics, And Bioimaging, Emi̇ne Sezer, Fulden Ulucan Karnak, Si̇nan Akgöl Oct 2025

Green Carbon Dots In The Era Of Ai: Sustainable Synthesis, Intelligent Drug Delivery, Advanced Diagnostics, And Bioimaging, Emi̇ne Sezer, Fulden Ulucan Karnak, Si̇nan Akgöl

Turkish Journal of Biology

Background/aim: Green carbon dots (GCDs) are a rapidly developing class of nanomaterials that are revolutionizing various scientific disciplines due to their unique optical properties, low toxicity, and sustainable synthesis. This review offers a comprehensive roadmap for the field, emphasizing the synergy between GCDs and artificial intelligence (AI).

Materials and methods: We begin by detailing the sustainable synthesis of GCDs, highlighting green chemistry principles and the transformative role of AI in optimizing their production. Subsequently, we explore the critical characterization of GCDs, including their structural, optical, and biocompatibility assessment. The core of this study explores the diverse biomedical applications of GCDs, …


Artificial Intelligence In Medical And Biological Research: Promise And Perils Of Chatgpt And Deepseek In Advancing Healthcare, Mahmut Enes Kayaalp, Onur Gülteki̇n, Serhat Akçaalan, Hami̇t Çağlayan Kahraman, Hüseyi̇n Nevzat Topçu, Gülşah Kavrul Kayaalp Oct 2025

Artificial Intelligence In Medical And Biological Research: Promise And Perils Of Chatgpt And Deepseek In Advancing Healthcare, Mahmut Enes Kayaalp, Onur Gülteki̇n, Serhat Akçaalan, Hami̇t Çağlayan Kahraman, Hüseyi̇n Nevzat Topçu, Gülşah Kavrul Kayaalp

Turkish Journal of Biology

Background/aim: Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT and DeepSeek, is being increasingly applied in clinical care, research, and education. The aim of this review is to examine how these tools may transform the conduct of medical and biological research and to define their limitations.

Materials and methods: A narrative synthesis of the literature was performed, encompassing studies published between 2020 and 2025. Peer-reviewed journals, systematic reviews, and high-impact original research articles were included to ensure an evidence-based overview. The principle applications, validation metrics, and clinical implications across orthopedics, oncology, cardiology, internal medicine, and the biological …


A Systematic Review Of Machine Learning In Heart Disease Prediction, Tathagat Banerjee, İshak Paçal Oct 2025

A Systematic Review Of Machine Learning In Heart Disease Prediction, Tathagat Banerjee, İshak Paçal

Turkish Journal of Biology

Background/aim: Cardiovascular diseases (CVDs) are a leading cause of global mortality, prompting the need for advanced predictive tools. While machine learning (ML) offers a powerful solution, there are significant challenges to clinical translation. This systematic review synthesizes the current state of ML in heart disease prediction, evaluating algorithmic performance, data utilization, and key translational challenges.

Materials and methods: Following PRISMA guidelines, a systematic search of literature published up to 2025 was conducted. From an initial pool of over 2500 records, a rigorous screening process yielded 65 studies for in-depth qualitative synthesis.

Results: Analysis showed that ensemble learning models dominate prediction …


Royal Jelly With Ellagic Acid Inhibits The Glycolytic Pathway And Induces Apoptosis Through Multiple Pathways In Colorectal Cancer, Tuğba Kul Köprülü Oct 2025

Royal Jelly With Ellagic Acid Inhibits The Glycolytic Pathway And Induces Apoptosis Through Multiple Pathways In Colorectal Cancer, Tuğba Kul Köprülü

Turkish Journal of Biology

Background/aim: Developing novel chemotherapeutics with high anticancer efficacy and low toxicity remains a critical challenge in oncology. Natural products have shown promise due to their multitargeted activity and favorable safety profiles. The present study investigates the combined anticancer effects of royal jelly (RJ) and ellagic acid (EA), two potent antioxidants of animal and plant origin.

Materials and methods: Royal jelly (RJ) and ellagic acid (EA) were applied to HT29 (ATCC HTB-38, Human colorectal adenocarcinoma), HCT116 (ATCC CCL-247, Human colorectal carcinoma) and BEAS-2B (ATCC CRL-3588, human bronchial epithelium) cell lines, and their antiproliferative effects were evaluated using a xCELLigence Real-Time Cell …


Tumor-Specific Cytotoxicity Of Pyrazole-Based Chalcone Derivatives In Human Oral Squamous Cell Carcinoma Cell Lines, Mehtap Tuğrak Sakarya, Hali̇se İnci̇ Gül, Hiroshi Sakagami, Junko Nagai, Yoshihiro Uesawa, Kenjiro Bandow Oct 2025

Tumor-Specific Cytotoxicity Of Pyrazole-Based Chalcone Derivatives In Human Oral Squamous Cell Carcinoma Cell Lines, Mehtap Tuğrak Sakarya, Hali̇se İnci̇ Gül, Hiroshi Sakagami, Junko Nagai, Yoshihiro Uesawa, Kenjiro Bandow

Turkish Journal of Biology

Background/aim: Pyrazole-based chalcone hybrids are notable in medicinal chemistry for their potential biological activity, although their tumor-specific cytotoxicity and mechanisms remain unknown in OSCC cells. This first study of pyrazole-chalcone hybrids in OSCC cells explores the tumor-selective cytotoxic effects and underlying cell death mechanisms triggered by a series of 10 newly synthesized pyrazole-based compounds (MS1MS10) in OSCC cell lines. Material and methods: The cytotoxic effects of the compounds were assessed using the MTT assay on four human OSCC cell lines and three types of normal human oral cells. The tumor-selectivity index (TS) and potency-selectivity expression (PSE) were calculated, and active …


Dramatic Biases In Terrestrial Nitrogen Fixation In Earth System Models Revealed By Natural Isotope Signatures, Maoyuan Fang, Shushi Peng, Philippe Ciais, Daniel S. Goll, Benjamin Z. Houlton, Ying-Ping Wang, Yilong Wang, Pan Liu, Joshua B. Fisher, Pierre Regnier Oct 2025

Dramatic Biases In Terrestrial Nitrogen Fixation In Earth System Models Revealed By Natural Isotope Signatures, Maoyuan Fang, Shushi Peng, Philippe Ciais, Daniel S. Goll, Benjamin Z. Houlton, Ying-Ping Wang, Yilong Wang, Pan Liu, Joshua B. Fisher, Pierre Regnier

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Biological nitrogen fixation (BNF) is the primary input of new reactive nitrogen to natural terrestrial ecosystems. However, this flux is poorly constrained due to its unclear drivers and associated control mechanisms. Here, we extend the existing theory of nitrogen (N) isotope mass balance to estimate BNF rates and then use a Bayesian approach to constrain the BNF rates in natural terrestrial ecosystems by using measurements of natural N-isotope ratios (δ15N) in plants (δP) and soil (δS). Together with pairwise δP and δS measurements from 18 forest sites covering diverse climates and thousands …


Study On The Flow Field Characteristics Of The Air-Suction Jujube Harvester Pipeline Based On Magnetohydrodynamic Airflow Control, Jing Nie, Qi Zhang, Jiashun Jiang, Jingbin Li, Longpeng Ding, Shufeng Li, Liming Xu, Mehmet Çeçen, Savaş Tanrisever Oct 2025

Study On The Flow Field Characteristics Of The Air-Suction Jujube Harvester Pipeline Based On Magnetohydrodynamic Airflow Control, Jing Nie, Qi Zhang, Jiashun Jiang, Jingbin Li, Longpeng Ding, Shufeng Li, Liming Xu, Mehmet Çeçen, Savaş Tanrisever

Turkish Journal of Agriculture and Forestry

This study aimed to address the issue of suction force attenuation in the air-suction jujube (red date) harvester due to pipeline pressure loss. The active flow control method based on magnetohydrodynamics was used to optimize the pipeline flow field and reduce pressure loss. Through multiphysics field coupling theory modeling and numerical simulation, the regulatory effects of different electromagnetic field parameters on the pipeline flow field were characterized. An experimental platform was established to verify that the optimized electrode tip density, electrode voltage, and magnetic induction intensity could significantly increase the outflow gas velocity, pressure difference, and harvesting efficiency of the …


Female Cardioprotection In A Mouse Model Of Alcohol-Associated Cardiomyopathy, Joshua M. Edavettal, Meagan Donovan, Nicholas R. Harris, Xavier R. Chapa-Dubocq, Keishla M. Rodríguez-Graciani, Janos Paloczi, Liz Simon, Bysani Chandrasekar, Jason D. Gardner Oct 2025

Female Cardioprotection In A Mouse Model Of Alcohol-Associated Cardiomyopathy, Joshua M. Edavettal, Meagan Donovan, Nicholas R. Harris, Xavier R. Chapa-Dubocq, Keishla M. Rodríguez-Graciani, Janos Paloczi, Liz Simon, Bysani Chandrasekar, Jason D. Gardner

School of Graduate Studies Faculty Publications

Chronic alcohol misuse is the leading cause of non-ischemic dilated cardiomyopathy, and the molecular mechanisms underlying the development of alcohol-associated cardiomyopathy (ACM), particularly regarding sex-specific susceptibility and mitochondrial contributions, are not fully known. In this study, we utilized a preclinical model of chronic + binge ethanol consumption to investigate sex differences in disease severity and mitochondrial function. Male and female C57BL/6J mice were fed ethanol or control liquid diets for 30 days, with 2 binge episodes on days 10 and 30. Cardiac morphology was assessed via echocardiography and cardiac function via left ventricular pressure-volume catheterization. Mitochondrial function was evaluated ex …


The Consciousness Inherent In Chasing Your Tail, Sergio M. Pellis Dr. Oct 2025

The Consciousness Inherent In Chasing Your Tail, Sergio M. Pellis Dr.

Animal Sentience

Who is conscious and how do we know? Complexity in behavior and cognition is certainly a clue that cannot be ignored in identifying this trait, and as Mather’s target article shows, it is hard not to imagine consciousness arising in cephalopods. But how complex is complex? An alternative may be gleaned from the fact that all living things rely on negative feedback to navigate their worlds, and this requires all sentient beings knowing what is to be stabilized in reflection to themselves. If so, consciousness is a universal trait.


The Role Of The Media In Health Education And Disease Prevention, Laura Binxhija, Diana Sejdiu, Bislim Krasniqi Oct 2025

The Role Of The Media In Health Education And Disease Prevention, Laura Binxhija, Diana Sejdiu, Bislim Krasniqi

UBT International Conference

This study examines the role of media in health education and disease prevention through a combined approach of literature review and empirical analysis. The survey was conducted through a structured questionnaire administered to a representative sample of 160 people. The data showed that 91.7% consider media an influential factor in shaping their health behaviors, while 85% reported making significant health-related decisions—such as visiting a doctor or changing dietary habits—based on information obtained from media sources. Social media (45%) and online portals (35%) emerged as the dominant channels for accessing health information. Despite a high perceived level of trustworthiness (48.5% considered …


Bioaqua Cost Action: Biomolecular Pathways To Sustainable Aquaculture – Transforming European Fish Farming Through Innovation And Collaboration, Besa Shahini Oct 2025

Bioaqua Cost Action: Biomolecular Pathways To Sustainable Aquaculture – Transforming European Fish Farming Through Innovation And Collaboration, Besa Shahini

UBT International Conference

European aquaculture is at a turning point. The sector is growing fast, but it also faces heavy disease pressure, rising costs, and stricter environmental demands. The BIOAQUA COST Action (CA22160) offers a new way forward. Instead of treating problems after they appear, it focuses on biomolecular tools that prevent them from the start. This paper looks at how continuous pathogen monitoring, water prophylaxis, eco-friendly treatments, and noninvasive welfare checks can cut losses, reduce antibiotic use, and strengthen biosecurity while keeping consumer trust. It also introduces BIOAQUA’s five working groups, which cover water prophylaxis, alternative treatments, fish welfare, sustainability pathways, and …


Technological Processing Of Wheat And Comparative Quality Analysis Of Flour Types Produced In 2024 And 2025, Nora Rrahimi, Aulona Sfishta, Resul Sahiti Oct 2025

Technological Processing Of Wheat And Comparative Quality Analysis Of Flour Types Produced In 2024 And 2025, Nora Rrahimi, Aulona Sfishta, Resul Sahiti

UBT International Conference

Wheat (Triticum spp.) is one of the most important agricultural crops worldwide and plays a key role in feeding the population. It is a fundamental raw material for staple foods such as bread, pasta, and other dough-based products. Flour, produced through wheat processing, is classified into types based on ash content, degree of refinement, and nutritional composition. Among the most widely used are types 400, 500, and 850, each with distinct technological properties and applications in the food industry. This paper studied the technological process of wheat milling and conducted a comparative analysis of flour types 400, 500, and 850 …


Understanding Rice Production Stagnation In The Philippines: Regional Evidence And Development Implications, Henry Bartelet, Alenn Jhulia D. Prodigalidad, Janelle S. Dy, Jan Gabriel N. Manzano Oct 2025

Understanding Rice Production Stagnation In The Philippines: Regional Evidence And Development Implications, Henry Bartelet, Alenn Jhulia D. Prodigalidad, Janelle S. Dy, Jan Gabriel N. Manzano

Quantitative Methods and Information Technology Faculty Publications

Despite decades of investment in agricultural research and rice development, the Philippines continues to face stagnation in domestic rice production. This persistent trend, occurring despite a sizable arable land base and large rural workforce, has contributed to the country’s growing reliance on rice imports to meet national food needs. In response, the government has implemented a tariff-based import system designed to fund domestic productivity improvements. While previous studies have explored the technical and environmental constraints affecting rice production, such as irrigation shortfalls, land degradation, and climate variability, few have examined recent national trends using regionally disaggregated data alongside qualitative insights. …


Transdiagnostic Alterations In White Matter Microstructure Associated With Suicidal Thoughts And Behaviours In The Enigma Suicidal Thoughts And Behaviours Consortium, Laura S Van Velzen, Lejla Colic, Zuriel Ceja, Maria R Dauvermann, Luca M Villa, Hannah S Savage, Yara J Toenders, Niousha Dehestani, Alyssa H Zhu, Adrian I Campos, Lauren E Salminen, Martin Alda, Ingrid Agartz, Nina Alexander, Rosa Ayesa-Arriola, Elizabeth D Ballard, Nerisa Banaj, Carlotta Barkhau, Zeynep Başgöze, Jochen Bauer, Francesco Benedetti, Klaus Berger, Bianca Besteher, Katharina Brosch, Manuel Canal-Rivero, Simon Cervenka, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Philippe Courtet, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Jeremy Deverdun, Ana M Diaz-Zuluaga, Lorielle M F Dietze, Jennifer W Evans, Negar Fani, Kira Flinkenflügel, Naomi P Friedman, Ian H Gotlib, Nynke A Groenewold, Dominik Grotegerd, Tomas Hajek, Alexander S Hatoum, Marco Hermesdorf, Ian B Hickie, Yoshiyuki Hirano, Tiffany C Ho, Yuki Ikemizu, Frank Iorfino, Jonathan C Ipser, Yuko Isobe, Andrea P Jackowski, Fabrice Jollant, Tilo Kircher, Melissa Klug, Sheri-Michelle Koopowitz, Anna Kraus, Axel Krug, Emmanuelle Le Bars, Elisabeth J Leehr, Meng Li, Elizabeth T C Lippard, Carlos Lopez-Jaramillo, Ivan I Maximov, Andrew M Mcintosh, Katie A Mclaughlin, Sean R Mcwhinney, Susanne Meinert, Elisa Melloni, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Stener Nerland, Emilie Olie, Victor Ortiz-García De La Foz, Pedro M Pan, Fabricio Pereira, Fabrizio Piras, Federica Piras, Sara Poletti, Andrew E Reineberg, Gloria Roberts, Rafael Romero-García, Matthew D Sacchet, Giovanni A Salum, Anca-Larisa Sandu, Carl M Sellgren, Eiji Shimizu, Harry R Smolker, Jair C Soares, J Douglas Steele, Frederike Stein, Dan J Stein, Benjamin Straube, Lea Teutenberg, Florian Thomas-Odenthal, Paula Usemann, Romain Valabregue, Johanna Valencia-Echeverry, Gerd Wagner, Gordon Waiter, Martin Walter, Heather C Whalley, Mon-Ju Wu, Tony T Yang, Carlos A Zarate, Andre Zugman, Giovana B Zunta-Soares, Kees Van Heeringen, Sanne J H Van Rooij, Nic Van Der Wee, Steven Van Der Werff, Paul M Thompson, Hilary P Blumberg, Anne-Laura Van Harmelen, Miguel E Rentería, Neda Jahanshad, Enigma Suicidal Thoughts And Behaviours Consortium, Lianne Schmaal Oct 2025

Transdiagnostic Alterations In White Matter Microstructure Associated With Suicidal Thoughts And Behaviours In The Enigma Suicidal Thoughts And Behaviours Consortium, Laura S Van Velzen, Lejla Colic, Zuriel Ceja, Maria R Dauvermann, Luca M Villa, Hannah S Savage, Yara J Toenders, Niousha Dehestani, Alyssa H Zhu, Adrian I Campos, Lauren E Salminen, Martin Alda, Ingrid Agartz, Nina Alexander, Rosa Ayesa-Arriola, Elizabeth D Ballard, Nerisa Banaj, Carlotta Barkhau, Zeynep Başgöze, Jochen Bauer, Francesco Benedetti, Klaus Berger, Bianca Besteher, Katharina Brosch, Manuel Canal-Rivero, Simon Cervenka, Romain Colle, Colm G Connolly, Emmanuelle Corruble, Philippe Courtet, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R Cullen, Udo Dannlowski, Jeremy Deverdun, Ana M Diaz-Zuluaga, Lorielle M F Dietze, Jennifer W Evans, Negar Fani, Kira Flinkenflügel, Naomi P Friedman, Ian H Gotlib, Nynke A Groenewold, Dominik Grotegerd, Tomas Hajek, Alexander S Hatoum, Marco Hermesdorf, Ian B Hickie, Yoshiyuki Hirano, Tiffany C Ho, Yuki Ikemizu, Frank Iorfino, Jonathan C Ipser, Yuko Isobe, Andrea P Jackowski, Fabrice Jollant, Tilo Kircher, Melissa Klug, Sheri-Michelle Koopowitz, Anna Kraus, Axel Krug, Emmanuelle Le Bars, Elisabeth J Leehr, Meng Li, Elizabeth T C Lippard, Carlos Lopez-Jaramillo, Ivan I Maximov, Andrew M Mcintosh, Katie A Mclaughlin, Sean R Mcwhinney, Susanne Meinert, Elisa Melloni, Philip B Mitchell, Benson Mwangi, Igor Nenadić, Stener Nerland, Emilie Olie, Victor Ortiz-García De La Foz, Pedro M Pan, Fabricio Pereira, Fabrizio Piras, Federica Piras, Sara Poletti, Andrew E Reineberg, Gloria Roberts, Rafael Romero-García, Matthew D Sacchet, Giovanni A Salum, Anca-Larisa Sandu, Carl M Sellgren, Eiji Shimizu, Harry R Smolker, Jair C Soares, J Douglas Steele, Frederike Stein, Dan J Stein, Benjamin Straube, Lea Teutenberg, Florian Thomas-Odenthal, Paula Usemann, Romain Valabregue, Johanna Valencia-Echeverry, Gerd Wagner, Gordon Waiter, Martin Walter, Heather C Whalley, Mon-Ju Wu, Tony T Yang, Carlos A Zarate, Andre Zugman, Giovana B Zunta-Soares, Kees Van Heeringen, Sanne J H Van Rooij, Nic Van Der Wee, Steven Van Der Werff, Paul M Thompson, Hilary P Blumberg, Anne-Laura Van Harmelen, Miguel E Rentería, Neda Jahanshad, Enigma Suicidal Thoughts And Behaviours Consortium, Lianne Schmaal

Faculty, Staff and Student Publications

Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity and radial diffusivity) for 24 WM tracts and one global measure were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of …


Leptin As A Key Driver For Organ Fibrogenesis, Xue-Nan Sun, Shiuhwei Chen, Shangang Zhao, Jan-Bernd Funcke, Megan Virostek, Line Pedersen, Chao Li, Chanmin Joung, Qian Lin, Yan Li, Ayanna Cobb, May-Yun Wang, Kyounghee Min, Lisandro Maya-Ramos, Giovanna Degasperi, Junquan Liu, Ningyan Zhang, Zhiqiang An, Diana R Tomchick, R Max Wynn, Da Young Oh, Philipp E Scherer Oct 2025

Leptin As A Key Driver For Organ Fibrogenesis, Xue-Nan Sun, Shiuhwei Chen, Shangang Zhao, Jan-Bernd Funcke, Megan Virostek, Line Pedersen, Chao Li, Chanmin Joung, Qian Lin, Yan Li, Ayanna Cobb, May-Yun Wang, Kyounghee Min, Lisandro Maya-Ramos, Giovanna Degasperi, Junquan Liu, Ningyan Zhang, Zhiqiang An, Diana R Tomchick, R Max Wynn, Da Young Oh, Philipp E Scherer

Faculty, Staff and Student Publications

Leptin, a hormone primarily secreted by adipocytes, regulates energy balance and systemic metabolism through its interaction with the leptin receptor (LEPR). Beyond these functions, leptin signaling has been implicated in the pathogenesis of tissue fibrosis. Here, we report the x-ray crystal structures of a leptin-neutralizing antibody (hLep3) in the unbound and leptin-bound states. The interaction of this antibody with leptin mimics the interaction of the LEPR with leptin, providing direct insights into the mechanism by which the antibody disrupts leptin signaling. We furthermore evaluate the therapeutic potential of neutralizing leptin with this antibody across distinct mouse models of fibrosis affecting …


Visible Image-Based Machine Learning For Identifying Abiotic Stress In Sugar Beet Crops, Seyed Reza Haddadi, Masoumeh Hashemi, Richard C. Peralta, Masoud Soltani Oct 2025

Visible Image-Based Machine Learning For Identifying Abiotic Stress In Sugar Beet Crops, Seyed Reza Haddadi, Masoumeh Hashemi, Richard C. Peralta, Masoud Soltani

Plants, Soils and Climate Student Research

Previous researches have proved that the synchronized use of inexpensive RGB images, image processing, and machine learning (ML) can accurately identify crop stress. Four Machine Learning Image Modules (MLIMs) were developed to enable the rapid and cost-effective identification of sugar beet stresses caused by water and/or nitrogen deficiencies. RGB images representing stressed and non-stressed crops were used in the analysis. To improve robustness, data augmentation was applied, generating six variations on each image and expanding the dataset from 150 to 900 images for training and testing. Each MLIM was trained and tested using 54 combinations derived from nine canopy and …


Development And Validation Of A Running Drill Test Battery To Predict 5 M And 20 M Sprint Performance, Paula Matijašević, Josip Maleš, Luka Cikojević, Frane Žuvela, Goran Kuvačić Oct 2025

Development And Validation Of A Running Drill Test Battery To Predict 5 M And 20 M Sprint Performance, Paula Matijašević, Josip Maleš, Luka Cikojević, Frane Žuvela, Goran Kuvačić

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1269-1285, 2025. https://doi.org/10.70252/LYKE8231 This study aimed to evaluate the reliability and predictive validity of specific athletic running drills: A-skip, B-skip, bounding step, and jumps, in relation to sprint performance over 5 m and 20 m distances. Sixty-three young males (mean age: 21.3 ± 2.1 years; body height: 183 ± 6.5 cm; body weight: 77 ± 9.3 kg) were enrolled in the study. Running drill performance was recorded on an athletics track using high-speed cameras and evaluated based on predefined criteria and a scoring system. Reliability was assessed using intraclass correlation coefficients (ICC) and coefficients …


Relationship Between Parent Demographics And Attitudes About Their Child’S Diabetes In Nigerian Parents Who Live In The United States, Vivian Obioma Nwankwo Oct 2025

Relationship Between Parent Demographics And Attitudes About Their Child’S Diabetes In Nigerian Parents Who Live In The United States, Vivian Obioma Nwankwo

Walden Dissertations and Doctoral Studies

Relationship Between Parent Demographics and Attitudes About Their Child’s Diabetes in Nigerian Parents who Live in the United States by Vivian Obioma Eluwa Nwankwo MA, Walden University, 2018 BA, University of Nigeria, 1992 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Human and Social Services Walden University August 2025


Evaluation Of Host Resistance To Rotylenchulus Reniformis In Sweetpotato Germplasm, Timothy S. Miller Oct 2025

Evaluation Of Host Resistance To Rotylenchulus Reniformis In Sweetpotato Germplasm, Timothy S. Miller

LSU Master's Theses

The reniform nematode (Rotylenchulus reniformis) is an emerging plant-parasitic threat to sweetpotato production. Dissimilar from the galling caused by root-knot nematode infections, infections from the reniform nematode occur without visible damage to the root system. In the southern United States, heavily infested sweetpotato fields can lose up to 40% of their total yield. Growers rely heavily on fumigants and nematicides which provide inconsistent control and are not sustainable in the long-term. Past research has been more focused on the efficacy of chemicals than in the identification of host resistance or tolerance in sweetpotato germplasm. This study evaluated past …


Oxygen Supply Capacity Of The Atlantic Horseshoe Crab,, Marty Sims Oct 2025

Oxygen Supply Capacity Of The Atlantic Horseshoe Crab,, Marty Sims

USF Tampa Graduate Theses and Dissertations

The horseshoe crab, Limulus polyphemus, inhabits shallow bays and estuaries where it encounters variable oxygen levels. Moreover, each year, the biomedical industry harvests hemolymph from hundreds of thousands of horseshoe crabs to use in bacterial contamination testing, yet the effects of bloodletting on their physiology are relatively unknown. This study aims to determine the oxygen supply capacity of Limulus polyphemus in relation to environmental hypoxia and biomedical bloodletting. Study animals were collected from the intertidal waters of Tampa Bay, Florida. Experiments included a control group that did not undergo substantial blood-volume reduction and a treatment group from which 10% of …


The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill Oct 2025

The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill

Biology Faculty Publications

The genome of the hemlock woolly adelgid (Adelges tsugae) is presented in 10 chromosomal pseudomolecules along with 132 unplaced scaffolds for a combined length of 216.56 Mb. The genome is highly contiguous with an N50 of 20.54 Mb and its longest scaffold 37.41 Mb in length. The assembly recovered 97.7% of benchmarked universal single-copy Hemiptera orthologs (BUSCO) with an overall completion score of 98.6%. On the basis of chromosomal synteny with other aphid genomes, the hemlock woolly adelgid’s genome is composed of eight autosomes and two sex (X) chromosomes. Annotation of the assembly identified 11,800 coding genes, 1,930 …


Perceived Recovery And Muscle Fatigue In Professional Soccer Players During Preseason, Josip Maleš, Frane Žuvela, Nicola Bragazzi, Andrea De Giorgio, Goran Kuvačić Oct 2025

Perceived Recovery And Muscle Fatigue In Professional Soccer Players During Preseason, Josip Maleš, Frane Žuvela, Nicola Bragazzi, Andrea De Giorgio, Goran Kuvačić

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1212-1227, 2025. https://doi.org/10.70252/ERIN2946 This study aimed to examine weekly variations and within-subject relationships between internal training intensity (ITI), perceived recovery (TQR), neuromuscular performance (CMJ), and perceived muscle soreness (PMS) during a four-week preseason period in professional soccer players. Twenty-three soccer players (age 24.8 ± 4.4 years; height 182 ± 7 cm; body mass 74.6 ± 6.7 kg) classified as Tier 3 athletes from the Croatian Second Soccer League were monitored using session rating of perceived exertion, TQR scales, countermovement jump tests, and PMS questionnaires. A significant reduction in ITI and concurrent improvement in TQR …


Effects Of A Quadricep-Dominant Vs. Functional Training Program On Activities Of Daily Living, Functional Performance, And Motor Unit Recruitment In Older Adults, Brittany Followay, Tamera Holland, Larissa Rowley Oct 2025

Effects Of A Quadricep-Dominant Vs. Functional Training Program On Activities Of Daily Living, Functional Performance, And Motor Unit Recruitment In Older Adults, Brittany Followay, Tamera Holland, Larissa Rowley

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1096-1113, 2025. https://doi.org/10.70252/YHYC9630 The study investigated the effects of a quadriceps-dominant (QD) versus functional (FX) training program on the Functional Movement Screen (FMS), activities of daily living (ADLs), and motor unit (MU) recruitment of the vastus lateralis (VL) and biceps femoris (BF). Twenty-six older adults (68.9 + 5.1yrs) were randomly assigned to a 6-week QD or FX training program. Participants completed ADLs, FMS, and three closed-kinetic chain exercises (CKCs): front lunge (FL), side lunge (SL), and bilateral squat (BLSQ), pre and post-intervention. Electromyography was recorded from the VL and BF during maximal voluntary isometric …


Where Is The Power In A Power Analysis?, Kevin D. Dames, Zoe Climenhaga, Jared Rosenberg Oct 2025

Where Is The Power In A Power Analysis?, Kevin D. Dames, Zoe Climenhaga, Jared Rosenberg

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 1114-1120, 2025. https://doi.org/10.70252/AVGK2063 Strategic planning of research involves predicting the number of replications of the experiment needed to detect an expected effect. The power analysis to determine sample size for the proposed experiment requires known or estimated characteristics of existing distributions. When used well, power analysis reduces the risk of statistical errors, wasted efforts, and temptations to twist ensuing analyses to eke out a ‘significant’ result after data collections conclude. This editorial highlights some examples of how this process goes awry. Sections are dedicated to the role of researchers, the case for ‘pilot’ studies, …


Hemodynamic And Autonomic Modulation In Response To Additive Sympathetic Stressors In Young, Healthy Individuals, J. Derek Kingsley, Anthony G. Pinzone, Gretchen E. Elsey, Stacie M. Humm Oct 2025

Hemodynamic And Autonomic Modulation In Response To Additive Sympathetic Stressors In Young, Healthy Individuals, J. Derek Kingsley, Anthony G. Pinzone, Gretchen E. Elsey, Stacie M. Humm

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 1047-1060, 2025. https://doi.org/10.70252/WWDK4926 Isometric handgrip (IHG) coupled with post-exercise muscular ischemia (PEMI) and the cold pressor test (CPT) have been demonstrated to increase measures of hemodynamics and to reduce vagal tone. However, little is known about how acute resistance exercise (RE) alters these responses. The purpose was to evaluate an acute bout of RE in conjunction with a single- or dual-stressor task on hemodynamics and autonomic modulation in resistance-trained individuals. Ten resistance-trained individuals (Mean ± SD; Age: 23 ± 3 years) completed a single- (SS: IHG + PEMI only) or dual-stressor (DS: IHG + …


The Effect Of Ankle Bracing On Athletic Performance Variables In Healthy Young Adult Athletes, Penny L. Head, Kurt Neelly, Karen Furgal, Sydney Graves, Meredith Jordan, Mackenzie Polston, Zach Powars, Hailey Shuttleworth, Daniel Smalling Oct 2025

The Effect Of Ankle Bracing On Athletic Performance Variables In Healthy Young Adult Athletes, Penny L. Head, Kurt Neelly, Karen Furgal, Sydney Graves, Meredith Jordan, Mackenzie Polston, Zach Powars, Hailey Shuttleworth, Daniel Smalling

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 1086-1095, 2025. https://doi.org/10.70252/XPTX6116 Acute ankle sprains are common in sports and carry a significantly increased risk of recurrence after an initial injury. Bracing has been shown to reduce injury recurrence; however, athletes may decline this prophylactic measure due to fear of negative effect on athletic performance. Previous research examining the impact of bracing on performance has demonstrated conflicting results. The purpose of this study was to examine the effect of bracing on choice reaction time and foot speed in healthy, young adults using computerized agility testing. Twenty-eight healthy athletes aged 18-25 years completed the …


Effect Of Velocity-Based Training On Vertical Jump Performance By Beach Volleyball Players, Filipe Aquino, Igor Nasser, Wladymir Külkamp, Bruno Ribeiro Ramalho Oliveira, Diego Viana Gomes, Everton Crivoi Do Carmo, Walace Monteiro, Eduardo Latari Oct 2025

Effect Of Velocity-Based Training On Vertical Jump Performance By Beach Volleyball Players, Filipe Aquino, Igor Nasser, Wladymir Külkamp, Bruno Ribeiro Ramalho Oliveira, Diego Viana Gomes, Everton Crivoi Do Carmo, Walace Monteiro, Eduardo Latari

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1061-1071, 2025. https://doi.org/10.70252/DFMZ2015 The aim of this study was to examine variations in countermovement jump (CMJ) performance after two velocity-based training (VBT) protocols in the half-squat exercise. Sixteen male beach volleyball athletes performed CMJ tests before and after three experimental sessions on the half-squat exercise. The two VBT protocols were performed in three sets, at a mean propulsive velocity (~ 0.49 m•s−1) associated with relative intensity (~ 85% 1RM), with three minutes interset recovery. In the VL0-10 session, the participants stopped their sets upon reaching a velocity loss (VL) threshold of 10%. …