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The Hepatic Glucagon Receptor As A Novel Regulator Of Lifespan, Alexander Tate Lasher Sep 2025

The Hepatic Glucagon Receptor As A Novel Regulator Of Lifespan, Alexander Tate Lasher

All ETDs from UAB

In developed nations the average lifespan has nearly doubled over the last 200 years, and the proportion of humans living into old age is ever increasing. While this is certainly a testament to the effectiveness of modern medicine and infrastructure, it presents a unique challenge to public health. Gains to health have not necessarily kept pace with the gains in lifespan, and the expanding aged population positions age-associated diseases to reach unprecedented prevalence. In light of this challenge, a mechanistic understanding of the aging process is necessary to identify factors that control longevity and to ultimately develop strategies for healthy …


Evaluating Gains In Student Self-Efficacy In Scientific Literacy Associated With A Brief Curricular Intervention, Radhika Reddy, Olivia M. Ainsworth, Mackenzie J. Gray, Andrea Hildebrand, Jazzmine Waugh, Jennifer Lindwall, Javier Huerta, Thomas E. Keller Sep 2025

Evaluating Gains In Student Self-Efficacy In Scientific Literacy Associated With A Brief Curricular Intervention, Radhika Reddy, Olivia M. Ainsworth, Mackenzie J. Gray, Andrea Hildebrand, Jazzmine Waugh, Jennifer Lindwall, Javier Huerta, Thomas E. Keller

Biology Faculty Publications and Presentations

Undergraduate research experiences (UREs) are high-impact practices that enhance retention, motivation, and self-efficacy in science, particularly for students with limited prior exposure to scientific environments. However, many students-especially those from underrepresented or marginalized backgrounds-enter these experiences with low research self-efficacy, stemming from limited familiarity with academic language, scientific literature, and research communication. The Research Induction Curriculum (RIC) was designed to address this challenge by providing early, structured training in scientific literacy through scaffolded journal club discussions. The RIC introduces students to progressively more complex scientific articles, supports peer discussion, and builds confidence in reading, interpreting, and presenting scientific information. This …


Barriers And Timely Postoperative Radiation Therapy In Head And Neck Cancer, Megan T Nguyen, Emily Kistner-Griffin, Reid Demass, Bhisham S Chera, Chanita Hughes Halbert, Katherine R Sterba, Elizabeth G Hill, Brian Nussenbaum, Anthony J Alberg, Vlad C Sandulache, David J Hernandez, Ryan S Jackson, Sidharth V Puram, Russel Kahmke, Nosayaba Osazuwa-Peters, Gail Jackson, Sue S Yom, Evan M Graboyes Sep 2025

Barriers And Timely Postoperative Radiation Therapy In Head And Neck Cancer, Megan T Nguyen, Emily Kistner-Griffin, Reid Demass, Bhisham S Chera, Chanita Hughes Halbert, Katherine R Sterba, Elizabeth G Hill, Brian Nussenbaum, Anthony J Alberg, Vlad C Sandulache, David J Hernandez, Ryan S Jackson, Sidharth V Puram, Russel Kahmke, Nosayaba Osazuwa-Peters, Gail Jackson, Sue S Yom, Evan M Graboyes

Faculty, Staff and Students Publications

Importance: Initiation of postoperative radiation therapy (PORT) within 6 weeks of surgery is associated with improved outcomes among patients with head and neck squamous cell carcinoma. However, the relationship of barriers to care with timely PORT is unknown.

Objective: To categorize barriers to timely PORT, evaluate the association of barriers to care with initiation of timely PORT, and describe the primary reason for delay among patients without timely PORT.

Design, setting, and participants: This prospective cohort study at a US academic medical center included adults with head and neck squamous cell carcinoma undergoing curative-intent surgery with an indication for PORT. …


Editorial: A Step-By-Step Statistical Decision Framework For A Gender-Inclusive Approach In Sport And Exercise Science Research, James W. Navalta, Dustin W. Davis, Jafra D. Thomas, Whitley J. Stone Sep 2025

Editorial: A Step-By-Step Statistical Decision Framework For A Gender-Inclusive Approach In Sport And Exercise Science Research, James W. Navalta, Dustin W. Davis, Jafra D. Thomas, Whitley J. Stone

International Journal of Exercise Science

International Journal of Exercise Science 18(1): 1010-1029, 2025. The conflation of sex and gender in sport and exercise science research has led to gaps in representation and understanding of gender-inclusive outcomes. This invited editorial presents a framework to guide researchers in conducting statistical analyses that account for multiple gender identities beyond the traditional binary classification. The invited editorial guides deliberation on whether to test for sex or gender differences in sport or exercise science research. It prompts investigators to answer the question, “Is there a valid, literature-supported rationale for investigating sex or gender differences?” If “yes”, we propose approaches that …


Details Matter: Getting People Involved, Cheryl A. Burkhart-Kriesel Sep 2025

Details Matter: Getting People Involved, Cheryl A. Burkhart-Kriesel

Cornhusker Economics

Sometimes getting people into the habit of community participation can be a bit challenging, but two aspects can help make this a little easier. The first is to make sure that there are no organizational barriers in participating, and the second is to realize that community participation happens on several levels and that each level has certain expectations. When these expectations are clearly stated, people are more easily motivated to get involved and stay involved.

Setting up engagement from the beginning requires thought and attention to detail. It can be insignificant things, like choosing a date or picking a location, …


Stayin' Alive (Even Without Oxygen): Retinal Development In Austrofundulus Limnaeus, Carmen Zecilia Rodriguez Sep 2025

Stayin' Alive (Even Without Oxygen): Retinal Development In Austrofundulus Limnaeus, Carmen Zecilia Rodriguez

Dissertations and Theses

The vertebrate eye is one of the most metabolically active organs in the body and is particularly sensitive to environmental stressors such as oxygen deprivation. Understanding how eye development proceeds under such conditions can provide critical insights into mechanisms of cellular resilience, tissue organization, and developmental plasticity. The annual killifish Austrofundulus limnaeus represents a unique model for investigating these processes due to its remarkable tolerance to anoxia during embryogenesis. However, the wild-type form is heavily pigmented, limiting the effectiveness of traditional imaging techniques for studying eye development. This thesis characterizes eye development and anoxia resilience in both wild-type and melanin-deficient …


The Impact Of Public Relations Strategies On The Effectiveness Of Epidemic Management In Jordan: A Case Study Of Covid-19, Hazem Jamil Al-Rahahleh Sep 2025

The Impact Of Public Relations Strategies On The Effectiveness Of Epidemic Management In Jordan: A Case Study Of Covid-19, Hazem Jamil Al-Rahahleh

Middle East Journal of Communication Studies

This study aimed to explore the impact of public relations strategies on the effectiveness of epidemic management in Jordan, using the COVID-19 pandemic as a case study. The study employed the descriptive-analytical method, which is based on the systematic description and interpretation of social and media phenomena. The findings revealed that public relations play a pivotal strategic role in managing health crises by building public trust, preparing communication plans, and formulating awareness messages in coordination with relevant authorities. The study recommended the need to enhance the training of public relations personnel in managing communication during health crises, to continue diversifying …


Analysis Of A Human-Mediated Microbioinvasion: The Global Spread Of The Benthic Foraminifer Trochammina Hadai Uchio, 1962, Mary Mcgann, Maria Holzmann, Vincent M.P. Bouchet, Sibelle Trevisan Disaró, Patrícia P.B. Eichler, David W. Haig, Stephen J. Himson, Hiroshi Kitazato, Jean Charles Pavard, Irina Polovodova Asteman, André R. Rodrigues, Clément M. Tremblin, Masashi Tsuchiya, Mark Williams, Phoebe O'Brien, Josefin Asplund, Malou Axelsson, Thomas D. Lorenson Sep 2025

Analysis Of A Human-Mediated Microbioinvasion: The Global Spread Of The Benthic Foraminifer Trochammina Hadai Uchio, 1962, Mary Mcgann, Maria Holzmann, Vincent M.P. Bouchet, Sibelle Trevisan Disaró, Patrícia P.B. Eichler, David W. Haig, Stephen J. Himson, Hiroshi Kitazato, Jean Charles Pavard, Irina Polovodova Asteman, André R. Rodrigues, Clément M. Tremblin, Masashi Tsuchiya, Mark Williams, Phoebe O'Brien, Josefin Asplund, Malou Axelsson, Thomas D. Lorenson

Research outputs 2022 to 2026

A non-indigenous species (NIS) of benthic foraminifera was first identified in a core collected in 1993 in San Francisco Bay, California, USA, and subsequently identified as Trochammina hadai Uchio, 1962. Archived samples and literature reviews were used to determine that the species, which is native to Asia, arrived in San Francisco Bay between the early 1960s and 1983. Through molecular analyses of specimens, archived samples and literature reviews from 1930-1983, and site surveys of harbors and estuaries along the western North American seaboard in 1994-2024, in total more than 2500 samples, we documented the presence of T. hadai at 73 …


Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled Sep 2025

Defining Breast Epithelial Cell Types In The Single-Cell Era, G Kenneth Gray, Eric G Carlson, Tatyana Lev, Bailey Marshall, Austin D Reed, Alex P Sánchez-Covarrubias, Alecia-Jane Twigger, Aleix Puig-Barbe, Aatish Thennavan, Ayodele Omotoso, Lyndsay M Murrow, Deeptiman Chatterjee, Siyuan He, Sara Pensa, Brian Aevermann, Norbert K Tavares, Natalie Chen, Jason A Hilton, Kerrigan Blake, Yunlong Liu, Kiet Phong, Zev J Gartner, Devon A Lawson, Alexander Swarbrick, Camila O Dos Santos, Sophia H L George, Joan S Brugge, Mark A Labarge, Harikrishna Nakshatri, Nicholas Navin, Kai Kessenbrock, Walid T Khaled

Faculty, Staff and Student Publications

Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.


Author Correction: Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p131 Breast-Ovarian Cancer Susceptibility Locus, Kate Lawrenson, Siddhartha Kar, Karen Mccue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Matthias W Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Cannioto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B M Claes, Linda S Cook, Angela Cox, Daniel W Cramer, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A Doherty, Susan M Domchek, Cecilia M Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, Christoph Engel, Eunjung Lee, D Gareth Evans, Peter A Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D Foulkes, Brooke L Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G Giles, Rosalind Glasspool, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Ellen L Goode, Marc T Goodman, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Patricia A Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K Høgdall, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Peter J Hulick, Tomasz Huzarski, Evgeny N Imyanitov, Kconfab Investigators, Australian Ovarian Cancer Study Group, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y Karlan, Sofia Khan, Lambertus A Kiemeney, Susanne Kruger Kjaer, Julia A Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel De La Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F A G Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley Mcguffog, Catriona Mclean, Iain Mcneish, Alfons Meindl, Usha Menon, Arjen R Mensenkamp, Roger L Milne, Marco Montagna, Kirsten B Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, Roberta B Ness, Susan L Neuhausen, Heli Nevanlinna, Silje Nord, Robert L Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Curtis Olswold, David O'Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Elizabeth M Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B Salvesen, Suleeporn Sangrajrang, Elinor J Sawyer, Joellen M Schildkraut, Marjanka K Schmidt, Rita K Schmutzler, Thomas A Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F Singer, Olga M Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R Teixeira, Soo H Teo, Kathryn L Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Nadine Tung, Shelley S Tworoger, Celine Vachon, Ans M W Van Den Ouweland, Helena C Van Doorn, Elizabeth J Van Rensburg, Laura J Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Hans Wildiers, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N Monteiro, Juliet D French, Fergus J Couch, Matthew L Freedman, Douglas F Easton, Alison M Dunning, Paul D Pharoah, Stacey L Edwards, Georgia Chenevix-Trench, Antonis C Antoniou, Simon A Gayther Sep 2025

Author Correction: Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p131 Breast-Ovarian Cancer Susceptibility Locus, Kate Lawrenson, Siddhartha Kar, Karen Mccue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Matthias W Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Cannioto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B M Claes, Linda S Cook, Angela Cox, Daniel W Cramer, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A Doherty, Susan M Domchek, Cecilia M Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, Christoph Engel, Eunjung Lee, D Gareth Evans, Peter A Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D Foulkes, Brooke L Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G Giles, Rosalind Glasspool, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Ellen L Goode, Marc T Goodman, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Patricia A Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K Høgdall, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Peter J Hulick, Tomasz Huzarski, Evgeny N Imyanitov, Kconfab Investigators, Australian Ovarian Cancer Study Group, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y Karlan, Sofia Khan, Lambertus A Kiemeney, Susanne Kruger Kjaer, Julia A Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel De La Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F A G Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley Mcguffog, Catriona Mclean, Iain Mcneish, Alfons Meindl, Usha Menon, Arjen R Mensenkamp, Roger L Milne, Marco Montagna, Kirsten B Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L Nathanson, Roberta B Ness, Susan L Neuhausen, Heli Nevanlinna, Silje Nord, Robert L Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Curtis Olswold, David O'Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Elizabeth M Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B Salvesen, Suleeporn Sangrajrang, Elinor J Sawyer, Joellen M Schildkraut, Marjanka K Schmidt, Rita K Schmutzler, Thomas A Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F Singer, Olga M Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R Teixeira, Soo H Teo, Kathryn L Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Nadine Tung, Shelley S Tworoger, Celine Vachon, Ans M W Van Den Ouweland, Helena C Van Doorn, Elizabeth J Van Rensburg, Laura J Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Hans Wildiers, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N Monteiro, Juliet D French, Fergus J Couch, Matthew L Freedman, Douglas F Easton, Alison M Dunning, Paul D Pharoah, Stacey L Edwards, Georgia Chenevix-Trench, Antonis C Antoniou, Simon A Gayther

Faculty, Staff and Student Publications

No abstract provided.


Increased Circulating Th17 Cells And Altered Cd4 T Cell Maturation And Differentiation In Active Tuberculosis With Type 2 Diabetes: A Pilot Study, Paul Ogongo, Yoscelina Estrella Martinez-Lopez, Anthony Tran, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ilse A. Dominguez-Trejo, Genesis P. Aguillón-Durán, Esperanza M. Garcia-Oropeza, Blanca I. Restrepo Sep 2025

Increased Circulating Th17 Cells And Altered Cd4 T Cell Maturation And Differentiation In Active Tuberculosis With Type 2 Diabetes: A Pilot Study, Paul Ogongo, Yoscelina Estrella Martinez-Lopez, Anthony Tran, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ilse A. Dominguez-Trejo, Genesis P. Aguillón-Durán, Esperanza M. Garcia-Oropeza, Blanca I. Restrepo

School of Medicine Publications

Introduction: Type 2 diabetes (T2D) is a major risk factor for developing tuberculosis (TB). However, understanding the role of defective T cell responses in T2D and TB has been difficult, largely due to inconsistencies across studies. These discrepancies often stem from T cell subset classification primarily relying on cytokine expression profiles, which may not fully capture the complexity of T cell maturation, differentiation, and function in TB patients with T2D.

Objective and methods: In this pilot study, we sought to identify alterations in phenotypic and ex vivo responses of CD4 T cells to Mycobacterium tuberculosis (Mtb) antigens in people with …


Dairy And Food Science Student Newsletter, September 4, 2025, Department Of Dairy And Food Science Sep 2025

Dairy And Food Science Student Newsletter, September 4, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.


Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models, Salma S. Abdelmaboud Sep 2025

Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models, Salma S. Abdelmaboud

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) is a leading cause of long-term neurological impairment, with aging significantly increasing vulnerability and worsening outcomes. Older individuals experience greater cognitive and motor deficits after TBI and often show diminished responses to therapeutic interventions. Both aging and TBI independently promote heightened neuroinflammation and cognitive dysfunction, increasing susceptibility to poor recovery. This study investigated the therapeutic potential of small extracellular vesicles (sEVs) derived from human adipose-derived stem cells (hASCs) to promote neurological recovery and modulate neuroinflammation in a mouse model of TBI. Male C57BL/6 mice aged 3, 15, and 20 months underwent controlled cortical impact (CCI) and …


P.L.A.Y. For All Pilot: Effects Of A Community-Based, Inclusive After-School Program On Physical Activity And Motor-Skill Outcomes, Allison R. Tsuchida, Karl-Richard Hennebach, Erin E. Centeio Sep 2025

P.L.A.Y. For All Pilot: Effects Of A Community-Based, Inclusive After-School Program On Physical Activity And Motor-Skill Outcomes, Allison R. Tsuchida, Karl-Richard Hennebach, Erin E. Centeio

International Journal of Physical Activity and Health

After-school programs for physical activity (PA) can contribute to helping children and youth achieve the suggested 60 minutes a day of PA. Previous research also suggests that developing motor competency can positively impact long-term PA participation. Additionally, parent and peer support can help children and youth overcome barriers to PA participation. The primary purpose of this pilot research study was to determine the effects of an inclusive after-school program on PA levels and motor-skill outcomes for children with and without disabilities. A secondary purpose was to examine parental support for physical activity and children’s physical activity and motor skills. 38 …


A Comprehensive Framework For Assessing Terrestrial Analogue Field Sites For Ocean Worlds, Jennifer C. Stern, Heather V. Graham, Bradley Burcar, Emily S. Martin, Aaron Noell, Kevin Hand, Jeff S. Bowman, Peter Doran, Virginia Edgcomb, James F. Holden, Alta E.G. Howells, Michael J. Malaska, Brook L. Nunn, Jani Radebaugh, Laura E. Rodriguez, Schuyler Borges, Dina Bower, Samuel Courville, Melisa Diaz, Benjamin Hockman, Julie Huber, Justin Lawrence, Trista Vick-Majors, Conor A. Nixon, John R. Spear, Amanda V. Steckel, Anezina Solomonidou, Nicholas Schmerr, Britney Schmidt, Matthew O. Schrenk, Lauren Seyler Sep 2025

A Comprehensive Framework For Assessing Terrestrial Analogue Field Sites For Ocean Worlds, Jennifer C. Stern, Heather V. Graham, Bradley Burcar, Emily S. Martin, Aaron Noell, Kevin Hand, Jeff S. Bowman, Peter Doran, Virginia Edgcomb, James F. Holden, Alta E.G. Howells, Michael J. Malaska, Brook L. Nunn, Jani Radebaugh, Laura E. Rodriguez, Schuyler Borges, Dina Bower, Samuel Courville, Melisa Diaz, Benjamin Hockman, Julie Huber, Justin Lawrence, Trista Vick-Majors, Conor A. Nixon, John R. Spear, Amanda V. Steckel, Anezina Solomonidou, Nicholas Schmerr, Britney Schmidt, Matthew O. Schrenk, Lauren Seyler

Michigan Tech Publications

Field studies at terrestrial analogue sites represent an important contribution to the science of ocean worlds. The value of the science and technology investigations conducted at field analogue sites depends on the relevance of the analogue environment to the target ocean world. We accept that there are no perfect analogues for many of the unique environments represented by ocean worlds but suggest that a one-to-one matching of environmental characteristics and conditions is not crucial to the success or impact of the work. Instead, we must determine which processes and parameters are required to map directly to the target ocean world …


Enhancing The Care Of Patients With Bone And Joint Infections Through Educational Interventions, Neel B. Shah, Jessica Seidelman, Katherine Belden, Elizabeth Thottacherry, Allison Lastinger, Priya Nori, Ronald M. Beaulieu, Don Bambino Geno Tai Sep 2025

Enhancing The Care Of Patients With Bone And Joint Infections Through Educational Interventions, Neel B. Shah, Jessica Seidelman, Katherine Belden, Elizabeth Thottacherry, Allison Lastinger, Priya Nori, Ronald M. Beaulieu, Don Bambino Geno Tai

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Musculoskeletal infections represent a significant proportion of the clinical workload for infectious diseases (ID) providers, often presenting complex diagnostic and therapeutic challenges. Many providers may feel inadequately prepared to manage these conditions, which require a nuanced understanding of microbiology, musculoskeletal anatomy, surgical intervention, and orthopedic hardware. We implemented a pair of educational interventions including an online library of high-yield musculoskeletal ID literature and an educational podcast. © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.


Targeting Aldh16a1 Mediated Thioredoxin Lysosomal Degradation To Enhance Ferroptosis Susceptibility In Smarca4-Deficient Nsclc, Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan Sep 2025

Targeting Aldh16a1 Mediated Thioredoxin Lysosomal Degradation To Enhance Ferroptosis Susceptibility In Smarca4-Deficient Nsclc, Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan

Faculty, Staff and Student Publications

Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN's oxidoreductase function by occluding its active site. We also show that …


Using Automated Activity Monitoring To Detect Resumption Of Cyclicity In Early Lactation—Meta-Analysis, S. Borchardt, T.A. Burnett, T.C. Bruinjé, A.M.L. Madureira Sep 2025

Using Automated Activity Monitoring To Detect Resumption Of Cyclicity In Early Lactation—Meta-Analysis, S. Borchardt, T.A. Burnett, T.C. Bruinjé, A.M.L. Madureira

Dairy Science and Food Science Faculty Publications: 2022 to Present

This meta-analysis aimed to evaluate the efficacy of automated activity monitoring (AAM) in detecting estrous expression and ovulatory status in cows during the voluntary waiting period (VWP). A comprehensive literature search was conducted in PubMed, ScienceDirect, and Google Scholar using specific search terms. Inclusion criteria focused on studies that assessed estrous expression within the VWP using modern AAM systems alongside blood progesterone (P4) measurements. Four manuscripts involving 2,198 cows were included. Data extraction was performed by a single investigator and validated by a coauthor. The analysis considered estrous expression and ovulatory status determined through serial blood P4 measurements. Cows were …


First Confirmed Nebraska Breeding Record Of The Common Raven (Corvus Corax) Since The 19th Century, Eugene A. Huryn, Jacob C. Cooper Sep 2025

First Confirmed Nebraska Breeding Record Of The Common Raven (Corvus Corax) Since The 19th Century, Eugene A. Huryn, Jacob C. Cooper

Nebraska Bird Review

In Nebraska, the Common Raven was likely widespread prior to 1900, being codistributed with the American Bison (Bison bison). Records in this time are spotty, but consistent. Thomas Say reported a nearly fledged brood—the only confirmed breeding record in this period—at Fort Calhoun in Washington County on May 12, 1820. A Common Raven was collected at Fort Randall, on the Missouri River just north of the modern Nebraska–South Dakota border, in the fall of 1857 during the Lieutenant Warren Expeditions. Another specimen, now lost, was collected by J. B. Hasty in 1899 in Arapahoe, Furnas County. Bruner et …


The Effects Of Early Life Rearing Experiences And Age On Sociality In Captive Olive Baboons (Papio Anubis), Angela M. Achorn, Michele M. Mulholland, Chet C. Sherwood, Soojin V. Yi, William D. Hopkins Sep 2025

The Effects Of Early Life Rearing Experiences And Age On Sociality In Captive Olive Baboons (Papio Anubis), Angela M. Achorn, Michele M. Mulholland, Chet C. Sherwood, Soojin V. Yi, William D. Hopkins

Anthropology Faculty Publications

Social connections within primate groups are continuously changing, and an individual's connectedness within their social network can have important consequences on morbidity and mortality. Here, we examined the effects of early life social experiences and age on social connectedness of captive female olive baboons (Papio anubis). Subjects included 54 mother-reared (MR) and 35 nursery-reared (NR) baboons (4.03 to 19.8 years of age). We conducted four 15-min focal observations and recorded all social interactions. For every possible dyad, we calculated total amount of time in proximity to one another and total amount of time spent grooming (in each direction), then used …


Alpine Plants And Climate Change: Tracking Community Shifts In Yosemite National, Brooke L. Wallasch Sep 2025

Alpine Plants And Climate Change: Tracking Community Shifts In Yosemite National, Brooke L. Wallasch

Master's Theses

As climate change progresses, alpine plant communities are predicted to shift upslope as they track temperature over time. Relative to lowland environments, alpine areas are experiencing a faster rate of temperature change due to a phenomenon referred to as elevation-dependent warming. A common approach for tracking plant communities shifts over time, is to conduct resurveys of the same area at several time points, as the Global Observational Research Initiative in Alpine Environments (GLORIA) has done on mountain summits around the world since 2001. In 2011-2013, GLORIA developed a supplemental survey method whereby belt transects were established downslope of summits in …


Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam Sep 2025

Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam

Tennessee State University Alumni Theses and Dissertations

Nitrogen (N) is an essential but limiting macronutrient for crop growth in agroecosystems. Biological Nitrogen Fixation (BNF) is a critical biological process where atmospheric Nitrogen is converted into ammonia by Nitrogen fixing the bacteria called rhizobia, forming mutualistic relationships with legume plants. These interactions are mediated by several signaling pathways and may involve epigenetic modifications like DNA methylations, histone modifications, where gene expression is altered without any change in DNA sequence. Histones are proteins provide structural support to DNA. However, genes encoding enzymes for these post translational modifications are poorly investigated in the Leguminosae family. This project aims to answer …


Root Exudates: The Rhizospheric Frontier For Advancing Sustainable Plant Protection, Muhammad Rahil Afzal, Misbah Naz, Youbo Yu, Lisha Yan, Peiyi Wang, Janaki Mohotti, Gefei Hao, Jing-Jiang Zhou, Zhou Chen, Libo Zhang, Qian Wang Sep 2025

Root Exudates: The Rhizospheric Frontier For Advancing Sustainable Plant Protection, Muhammad Rahil Afzal, Misbah Naz, Youbo Yu, Lisha Yan, Peiyi Wang, Janaki Mohotti, Gefei Hao, Jing-Jiang Zhou, Zhou Chen, Libo Zhang, Qian Wang

Faculty Publications

Root exudates (REs), a diverse array of bioactive metabolites secreted by plant roots in response to environmental stimuli, serve as key mediators of rhizosphere ecology and plant defense responses, offering a promising avenue for sustainable pest management and eco-friendly plant protection. While earlier reviews primarily focus on root exudates in the context of general rhizosphere dynamics and plant-microbial interactions, critical knowledge gaps persist in REs-plant-pest tripartite interactions, the mechanistic basis of REs-mediated plant defense, and their practical integration with integrated pest management (IPM) frameworks. This review provides a synthesis of the latest literature on the biochemical diversity and functions of …


Impact Of Varied Dietary Macronutrient Ratios On The Nutrition Status Of Swiss Albino Mice, Hellen Kinyi, Charles Kato, Gertrude Kiwanuka Sep 2025

Impact Of Varied Dietary Macronutrient Ratios On The Nutrition Status Of Swiss Albino Mice, Hellen Kinyi, Charles Kato, Gertrude Kiwanuka

Biomedical Sciences, East Africa

The nutrition status of an organism depends on the balance between nutrient intake and utilization. Malnutrition results not only from inadequate caloric intake but also from imbalanced macronutrient ratios, which can affect aging, metabolism, and health. While many studies focus on individual nutrients, this study used purified, isocaloric diets with varying macronutrient ratios to assess dietary effects on nutrition markers in Swiss albino mice.

Mice were randomized into 6 dietary groups, each containing 6 males and 6 females housed separately. Each group received an isocaloric diet with different carbohydrate, protein, and lipid ratios for 15 weeks. Animal weight, body mass …


A Co-Design Approach To Integrating Gender Into The Cacao Value Chain In Davao City, Philippines, Mia Barbara Aranas, Aileen Lapitan, Mitchiko Lopez, Nico Jayson Anastacio, Canesio Predo, Mara Faylon, Emmanuel Flores, Claire Estelle Cruz, Anjelyn Joy Enong Sep 2025

A Co-Design Approach To Integrating Gender Into The Cacao Value Chain In Davao City, Philippines, Mia Barbara Aranas, Aileen Lapitan, Mitchiko Lopez, Nico Jayson Anastacio, Canesio Predo, Mara Faylon, Emmanuel Flores, Claire Estelle Cruz, Anjelyn Joy Enong

The Philippine Agricultural Scientist

The specific needs and challenges of women and their contributions are often not integrated when developing interventions and policies targeted to improve agricultural value chains. Therefore, this study developed a codesign approach to creating solutions to improve gender relations in agri-food value chains. Specifically, it focused on the cacao value chain in Davao City, which is located in the southern Philippines. Co-design is a highly participatory approach in which solutions are designed with, and not just for, the people who have lived experiences of the problems being addressed. The approach emphasizes understanding gender-related barriers and opportunities to inform government interventions …


Procedures For Rangeland Condition Assessment In The Pilbara And Southern Rangelands 2025, Department Of Primary Industries And Regional Development, Western Australia Sep 2025

Procedures For Rangeland Condition Assessment In The Pilbara And Southern Rangelands 2025, Department Of Primary Industries And Regional Development, Western Australia

Natural resources published reports

This report defines the procedures used in 2025 by DPIRD to complete rangeland condition assessment (RCA) in the Pilbara and southern rangelands region which has predominantly shrub-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Kimberley which has grass pastures.

RCA is the process DPIRD uses to make systematic, station-level assessment of rangeland. Rangeland condition considers both the condition of pastures (defined in the ‘Pasture condition guides for the Pilbara’ and ‘Pasture condition guides for the southern rangelands including the Gascoyne, Murchison and Goldfields-Nullarbor’) and soils as determined by erosion, using the …


Procedures For Rangeland Condition Assessment In The Kimberley 2025, Department Of Primary Industries And Regional Development, Western Australia Sep 2025

Procedures For Rangeland Condition Assessment In The Kimberley 2025, Department Of Primary Industries And Regional Development, Western Australia

Natural resources published reports

This report defines the procedures used in 2025 by DPIRD to complete rangeland condition assessment (RCA) in the Kimberley region which has grass-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Pilbara and southern rangelands which have predominantly shrub pastures.

RCA is the process DPIRD uses to make systematic, station-level assessment of rangeland. Rangeland condition considers both the condition of pastures (as defined in the 'Pasture condition guide for the Kimberley') and soils as determined by erosion, using the erosion assessment method on pastoral lands in Western Australia. The methods have evolved …


Randomized Trial: Peppermint Oil (Menthol) Pharmacokinetics In Children And Effects On Gut Motility In Children With Functional Abdominal Pain: 540 Mg Vs. 900 Mg Dose Comparison, Robert J Shulman, Bruno P Chumpitazi, Daniel Gonzalez, Uttam Garg, Salma Musaad, Jiali Wen, Gregory L Kearns Sep 2025

Randomized Trial: Peppermint Oil (Menthol) Pharmacokinetics In Children And Effects On Gut Motility In Children With Functional Abdominal Pain: 540 Mg Vs. 900 Mg Dose Comparison, Robert J Shulman, Bruno P Chumpitazi, Daniel Gonzalez, Uttam Garg, Salma Musaad, Jiali Wen, Gregory L Kearns

Children’s Nutrition Research Center Staff Publications

Aims: There is a paucity of information on the pharmacokinetics (PK) and pharmacodynamics (PD) of menthol, the active ingredient in peppermint oil (PMO). We studied the PK of menthol (540 and 900 mg) in children and measured their effects on gut transit/contractility.

Methods: Children 7-12 years of age with functional abdominal pain underwent wireless motility capsule (WMC) testing. One week later, they were randomized to 540 mg or 900 mg of oral enteric-coated PMO. Blood was sampled over 24 h to determine menthol PK. The WMC test was repeated while they took their respective dose (180 mg thrice or 180 …


Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein Sep 2025

Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein

Graduate Theses and Dissertations

The rise in global temperatures has become a concern due to its significant impact on the agricultural sector, including poultry production. Heat stress caused by high temperatures directly affects animal welfare, health and productivity, leading to major losses in the poultry sector. In broilers, heat stress affects feed consumption, weight gain, mortality and may also lead to changes in the microbiome, which can increase the predisposition to disease and impact the overall performance of these animals. The aim of this thesis was to reproduce field conditions, simulating an increase in temperature, and to evaluate possible changes in the respiratory and …


Impact Of Retail Display Case On Shelf-Life, Palatability, And Color-Stability Of Fresh Beef Steaks, Stephanie Elizabeth Shimer Sep 2025

Impact Of Retail Display Case On Shelf-Life, Palatability, And Color-Stability Of Fresh Beef Steaks, Stephanie Elizabeth Shimer

Graduate Theses and Dissertations

The objective of the study was to determine: the impact of two retail display cases, three beef muscles, and three packaging schemes on palatability traits, flavor development, lipid oxidation, objective and subjective evaluation of color stability, and microbial shelf-life. No muscle × package × case × day interactions were observed for any instrumental or panelist color evaluation (P > 0.851). No retail case effect was observed for TBARS, consumer sensory evaluation, or cook loss (P >0.05). A muscle × case × package interaction was observed for L* and b* (P< 0.05). No muscle × case × package observations were observed for shelf-life or palatability analyses (P > 0.05). No significant two-way or three-way interactions were observed for evaluation …