Digital Commons Network^™

Fermentabilitas Dan Kecernaan Ransum Domba Yang Mengandung Kulit Buah Pisang Muli (In Vitro), Iman Hernaman

Jurnal Ilmu Ternak Universitas Padjadjaran

Kulit buah pisang Muli memiliki potensi sebagai bahan pakan sumber serat pengganti rumput lapang, namun saat ini penggunaannya masih terbatas. Penelitian bertujuan untuk mempelajari penggunaan kulit buah pisang Muli dalam ransum terhadap fermentabilitas dan kecernaan (in vitro). Penelitian menggunakan rancangan acak lengkap dengan 4 perlakuan ransum yang mengandung 10, 20, 30, dan 40% kulit buah pisang Muli. Data yang terkumpul dianalisis dengan menggunakan Uji Duncan. Penelitian menghasilkan data yang memberi petunjuk adanya pengaruh nyata (P3yang terendah yaitu berturut-turut sebesar 161,5 mM, 66,72%, 66,15% dan 1,94 mM. Hasil penelitian menyimpulkan bahwa penggunaan kulit buah pisang Muli dapat sebanyak 40% dapat digunakan …

Pengaruh Konsentrasi Asam Sulfat (H2so4) Terhadap Rendemen, Mutu Fisik, Dan Mutu Kimia Gelatin Dari Limbah Shaving Kulit Kambing Pickel, Trianing Anggaeni

Jurnal Ilmu Ternak Universitas Padjadjaran

Salah satu alternatif penanganan limbah padat industri pengolahan kulit yang ekonomis dan bermanfaat adalah melalui pembuatan gelatin. Penelitian pembuatan gelatin dari limbah shaving kulit kambing pikel dengan konsentrasi asam sulfat sebagai bahan perencdam telah dilakukan dengan tujuan mengetahui pengaruh konsentrasi asam sulfat terhadap mutu kimia dan mendapatkan tingkat persentase konsentrasi asam sulfat terbaik. Penelitian dilakukan secara eksperimen menggunakan Rancangan Acak Lengkap dengan perlakuan 5 tingkat perendaman asam sulfat yaitu 1%, 2%, 3%, 4%, dan 5%. Setiap perlakuan diulang sebanyak 4 kali. Variabel yang diukur adalah rendemen, kekuatan gel, viskositas, kadar air, pH, dan kadar sulfit gelatin. Penggunaan asam sulfat konsentrasi …

Human-Mediated Dispersal And Breeding Reshape Global Genomic Patterns In Black Soldier Flies, Peter Muchina, Johnson Kinyua, Fathiya Khamis, Chrysantus M. Tanga, Rawlynce Bett, Geoffrey Ssepuuya, Dorothy Nakimbugwe, Mikkel-Holger S. Sinding, Grum Gebreyesus, Goutam Sahana, Zexi Cai

All Peer-Reviewed Publications

Human activities, either intentional or unintentional, have significantly influenced the global distribution and genetic composition of many species. The black soldier fly (Hermetia illucens; BSF) is a species native to North America that has rapidly gained commercial importance due to its bioconversion efficiency, upcycling organic waste into higher-value products. Through human-mediated dispersal associated with trade and insect farming, BSF has been introduced widely across the Old World, including Africa, where both wild and captive populations are now established. Despite its expanding global distribution, the demographic history and genomic consequences of these introductions remain poorly understood, particularly in Africa. This work …

Evaluasi Potensi Pakan Serat Dan Daya Dukung Untuk Pengembangan Ternak Ruminansia Di Wilayah Kabupaten Subang (Evaluation Of Forage And Agricultural Waste Potencies, Its Carring Capacity To Ruminant Developments In Subang), U Hidayat Tanuwiria, A. Budiman, B Ayuningsih

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini dilaksanakan di Kabupaten Subang. Penelitian bertujuan untuk mengetahui

potensi rumput dan pakan serat limbah asal tanaman pangan serta daya dukungnya untuk pengembangan ternak ruminansia di wilayah Kabupaten Subang. Penelitian ini bersifat eksploratif melalui analisis data primer dan sekunder. Data sekunder berupa data tataguna lahan, populasi ternak, produksi dan luas lahan pertanian. Data tersebut diperoleh dari Badan Pusat Statistik Kabupaten Subang. Hasil penelitian adalah sebagai berikut : (1) Potensi pakan di

Kabupaten Subang adalah 390.282 ton BK/tahun yang terdiri atas ton 61.585 BK.tahun-1 asal rumput dan 328.697 ton BK.tahun-1 asal limbah tanaman pangan. (2) Daya dukung pakan terhadap populasi …

Pengaruh Lama Pemeraman Dengan Nira Lontar Terhadap Perubahan Fraksi Serat Kulit Kopi Kering (The Effect Of Various Long Ripening In The Palm Juice On Fibre Of Dried Coffee Pulp), Serilus Bhia Tai, Redempta Wea, Agustinus Paga, Bernadete B. Koten

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini telah dilaksanakan di Laboratorium Umum Politeknik Pertanian Negeri Kupang.

Penelitian mulai dari Bulan November 2014–Januari 2015. Penelitian ini bertujuan untuk mengkaji pengaruh berbagai lama pemeraman dengan nira lontar terhadap fraksi serat kulit kopi kering, dirancang dengan metode rancangan acak lengkap (RAL), dengan 4 perlakuan dan 5 ulangan. Perlakuan tersebut adalah kulit kopi + nira lontar yang tidak diperam (K0), kopi + nira lontar yang diperam selama 6 hari (K1), diperam selama 12 hari (K2), diperam selama 18 hari (K3). Variabel yang diamati ialah kadar fraksi serat berupa Neutral Detergent Fiber (NDF), Acid Detergent Fiber (ADF), lignin, selulosa, dan …

Performa Domba Lokal Betina Dewasa Pada Berbagai Variasi Lamanya Penggembalaan Di Daerah Irigasi Rentang Kabupaten Majalengka ( Local Ewes Performance At Various Variation Of Length Grazing In Rentang Irigation Area Of Kabupaten Majalengka), Rachmat Somanjaya, Denie Heriyadi, Iman Hernaman

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian mengenai “Performa Domba Lokal Betina Dewasa pada Berbagai Variasi Lamanya Penggembalaan di Daerah Irigasi Rentang Kabupaten Majalengka”, telah dilaksanakan sejak Tanggal 25 Maret sampai 30 Juli 2015. Penelitian ini bertujuan untuk mengukur lamanya waktu penggembalaan optimum terhadap performa domba lokal betina dewasa yang digembalakan di Daerah Irigasi Rentang Kecamatan Jatitujuh Kabupaten Majalengka. Sampel Domba Lokal betina dewasa dalam penelitian ini adalah sebanyak 62 ekor yang tersebar pada variasi penggembalaan 6 jam 22 ekor. Metode penelitian yang digunakan adalah survey dan observasi. Data yang diperoleh dianalisis secara deskriptif, untuk mengetahui perbedaan rata-rata performa domba diuji dengan Analisys of Varian ( …

Longfin Mako (Isurus Paucus) Jaw, Nicholas D. Burchett, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Male Great Hammerhead (Sphyrna Mokarran) Chondrocranium, Michelle W. Bassali, Nicholas D. Burchett, Samuel Escobar, Preston Rice, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Male ~10ft Great Hammerhead (Sphyrna mokarran) Chondrocranium

Clinical Workflow Of Spine Stereotactic Radiotherapy And Radiosurgery: Insights From A Single-Institution Physics Perspective, Dennis Mackin, Gizem Cifter, Yana Zlateva, Jihong Wang, Yao Ding, Muhammad Shafiq Ul Hassan, Zhiheng Wang, Parmeswaran Diagaradjane, Fada Guan, Travis C Salzillo, Shane Krafft, Jing Li, Martin C Tom, Amol J Ghia, Tina Marie Briere

Faculty, Staff and Student Publications

Spine stereotactic radiotherapy and radiosurgery (SSRS) techniques, encompassing both fractionated stereotactic treatments and single-fraction radiosurgery, are widely used for the management of spinal metastases due to their ability to deliver highly conformal radiation while limiting dose to adjacent critical structures. Clinical outcomes following SSRS, including durable local control and acceptable toxicity, have been reported previously in multiple institutional series. In this manuscript, we describe the clinical workflow used to deliver SSRS at a high-volume academic center, with emphasis on the medical physics processes that support routine clinical practice. Key elements of the workflow include patient selection, treatment region-specific immobilization, CT …

Nighttime Or Daytime? How Milk Melatonin Levels Relate To Differential And Somatic Cell Count In Dairy Cow Milk, Eleonora Dall'olio, Claudio Cipolat-Gotet, Melania Andrani, Valeria Cavalli, Giovanni Ferri, Mario Baratta, Roberta Saleri, Fabio De Rensis

The Thai Journal of Veterinary Medicine

This study investigates the impact of winter nighttime versus daytime milking on melatonin concentration in milk and explores its relationship with somatic cell count (SCC) and differential somatic cell count (DSCC). Milk samples were collected from 40 Holstein cows at 12-hour intervals (04:00 AM Night samples and 04:00 PM Day samples) during the winter season (11 h of light and 13 h of darkness). The relationship between melatonin content, SCC and DSCC was assessed. Night milk had significantly higher melatonin levels (15.63 ± 1.90 pg/mL) compared to day milk (6.80 ± 0.75 pg/mL). SCC was significantly lower in night milk …

Effect Of Dietary Chitosan Oligosaccharide Levels And Molecular Weight With Deacetylation Degree Characteristics On Peptide Transporter 1 Gene Expression In Weaning Pig’S Small Intestine, Boonrit Thongsong, Sarinee Kalandakanond-Thongsong, Rath Pichyangkura

The Thai Journal of Veterinary Medicine

The present study aimed to assess the expression response of peptide transporter1 (PepT1) mRNA (SLC15A1) in weaning pig’s small intestine to the effect of dietary chitosan oligosaccharide (COS) supplement level, molecular weight (MW) and deacetylation degree (DD) characteristics. On days 28 and 56 of the experiments, small intestine samples obtained from our previous two experiments on weaned pigs were used to study the PepT1 mRNA expression. In experiment 1, pigs received either a basal diet or a basal diet supplemented with 75, 150, or 225 mg/kg COS. In experiment 2, pigs received either a basal diet or a basal diet …

Cost Effects Of Adding Poultry To Organic Vegetable Production Systems In California, Iowa, And Kentucky, Kwanele Magwaba, Alejandro Plastina, Ajay Nair, Maurice Pitesky, David J. Gonthier, Anne Carey, Faye Duan, Viktor Halmos

Journal of Applied Farm Economics

This study evaluates the economic viability of integrating poultry into organic vegetable crop rotations over three years in Kentucky and Iowa and two years in California. Given the growing global demand for food and heightened environmental awareness, understanding the financial implications of such integrated systems is crucial. Our comprehensive experiment compared integrated poultry-vegetable rotations with vegetable-only systems, assessing costs, revenues, and key factors influencing profitability. While integrating poultry reduced vegetable production costs by up to 10% in some cases, overall system costs increased due to high poultry expenses. Break-even poultry prices averaged $8/lb for low-density systems and $7 for high-density …

Are Returns From Commercial Farming Heterogeneous? Case Of Wheat Growers In North India, Saroj Verma, Kirtti Ranjan Paltasingh, Phanindra Goyari

Journal of Applied Farm Economics

Contract farming (CF), generally a commercial farming system, is widely perceived as a welfare enhancement strategy in rural areas where agriculture is the major source of livelihood. However, those welfare implications have not been adequately explored in Indian agriculture. So, this study examines the returns to CF and the heterogeneity in their returns across various groups of wheat growers in Haryana, a leading agrarian state in India. Using an endogenous switching regression model on cross-sectional data of 754 farm households, the study found that CF adopters would lose 27% of their gross margins and 11% of their crop output if …

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

Mulching And Time Of Planting Impact On Southern Blight Disease And Industrial Hemp Production, Sai Suvidh Maddela, Emmanuel C. Omondi, Margaret T. Mmbaga, Anand Kumar, Mitchell Dale Richmond, Philip O. Hinson, Bharat Pokharel

Agricultural and Environmental Sciences Faculty Research

Southern blight, a disease caused by the soil-borne fungus Sclerotium rolfsii (S. rolfsii), is favored by the hot and humid conditions of the southeastern United States, posing a significant challenge to hemp production in Tennessee. Black plastic mulch (BPM), commonly used for weed control, can exacerbate the disease. There is limited information on the effects of straw mulch (SM), known to moderate soil temperatures and moisture, or planting time in disease management. Field studies were conducted in 2022 and 2023 at Tennessee State University to evaluate the effects of planting time, mulch type, and biofungicide application on disease severity, weed …

Temporal Variation Of Benthic Aquatic Macroinvertebrate Communities In Two Upland Intermittent Streams In The Boston Mountains, R. J. Mccollough, K. B. Hecke

Journal of the Arkansas Academy of Science

Benthic aquatic macroinvertebrates are some of the most highly used organisms for biomonitoring and assessing stream health. However, biomonitoring is often done in one season, potentially missing important taxa and inaccurately reflecting the community as well as stream health. In addition, while road crossing effects have also been extensively researched the last few decades, these studies are also often conducted in one season, likely misrepresenting the community structure and the overall effects of the road crossing. The highly known River Continuum Concept (RCC) is often applied to these benthic aquatic macroinvertebrate communities. This study aimed to examine aquatic macroinvertebrate communities …

Low Intensity Vibration With Zoledronate Reduces Musculoskeletal Weakness And Adiposity In Estrogen Deprived Female Mice, Gabriel M Pagnotti, Trupti Trivedi, Laura E Wright, Sutha K John, Sreemala Murthy, Ryan R Pattyn, Monte S Willis, Yun She, Sukanya Suresh, Aji F Touray, William R Thompson, Clinton T Rubin, Khalid S Mohammad, Theresa A Guise

Faculty, Staff and Student Publications

Aromatase inhibitors are widely used in the treatment of hormone-sensitive breast cancer, but their suppression of estrogen production accelerates bone loss, increases fracture risk, and negatively impacts muscle and fat metabolism. Here, we demonstrate that daily low intensity vibration, serving as a non-drug mimetic for exercise, protects musculoskeletal health in skeletally immature, female mice under complete estrogen deprivation. Subsequent improvements in vertebral bone density are paralleled by greater and leaner skeletal muscle mass and function alongside reduced fat accretion and circulating metabolites. In mature, estrogen deprived mice, vibration enhances weekly bisphosphonate treatment, improving bone density, cortical thickness, and mechanical resistance …

Effect Of The Ahr Inhibitor Ch223191 As An Adjunct Treatment For Mammarenavirus Infections, Miguel Angel Pelaez, Jonna B. Westover, Dionna Scharton, Cybele Carina García, Brian B. Gowen

Animal, Dairy, and Veterinary Science Faculty Publications

The family Arenaviridae encompasses zoonotic, rodent-borne pathogens (e.g., Lassa, Machupo, and Junín viruses) that cause severe viral hemorrhagic fevers with high case fatality rates. The current therapeutic landscape is severely limited, underscoring the urgent need for novel antiviral strategies. A promising approach involves combining directly acting antivirals with host-targeted antivirals. A compelling host-targeted antiviral target is the aryl hydrocarbon receptor (AHR). This ubiquitous ligand-activated transcription factor is a recognized pro-viral host factor across multiple viral families. Building on prior work with Junín and Tacaribe viruses, we investigated whether the AHR inhibitor CH223191 could enhance the virus-directed antiviral activity of favipiravir …

Biology Department Publications: 2025, Sam Lindgren

Biology Department Bibliographies

This document is a non-comprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2024. It indexes those publications available through PubMed, and serves as an archival record of the Department's robust scholarly contributions.

Dapagliflozin Attenuates Cisplatin-Induced Nephrotoxicity In Rats Through Modulation Of Ros/Nf-Κb, Bcl2/Bax And Pink1/Parkin Signaling Pathways, Esraa K. Khallaf, Eman A. Ramadan, Mohey M. Elmazar, Marwa M. Safar

Pharmacy

Dapagliflozin (DPG), an anti-diabetic drug, has gained attention for its renal protective effects through multiple molecular pathways, yet its impact on mitophagy in cisplatin (CIS) nephrotoxicity remains unclear. This study aimed to examine the impact of DPG against CIS-induced nephrotoxicity in rats, targeting mainly PINK1/Parkin-mediated mitophagy and inflammatory/apoptotic pathways. Male Sprague Dawley rats received DPG (10 mg/kg; p.o) daily for 14 consecutive days and AKI was induced by a single injection of CIS (7 mg/kg; i.p) on day 10. Blood glucose, serum levels of creatinine and urea nitrogen, oxidative stress, inflammatory, apoptotic, mitophagy markers, and histological changes were assessed. DPG …

Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval

Faculty, Staff and Student Publications

The visual system performs a remarkable feat: it takes complex retinal activation patterns and decodes them for object recognition. This operation, termed "representational untangling," organizes neural representations by clustering similar objects together while separating different categories of objects. While representational untangling is usually associated with higher-order visual areas like the inferior temporal cortex, it remains unclear how the early visual system contributes to this process-whether through highly selective neurons or high-dimensional population codes. This article investigates how a computational model of early vision contributes to representational untangling. Using a computational visual hierarchy and two different data sets consisting of numerals …

Optimal Drought Management Actions For Cattle Operations On The Uintah And Ouray Indian Reservation, Kynda R. Curtis, Tatiana Drugova, Man-Keun Kim

All Current Publications

In this fact sheet, we examine the drought management options available to cattle operations on the Uintah and Ouray Reservation, the largest Native American reservation in Utah. Specifically, we discuss the results of a study that evaluated the economic outcomes of two common drought response strategies: herd reduction and supplemental hay purchases. We also provide recommendations for ranchers on optimal strategies, i.e., those that maximize profits for two rancher types, differentiated by their willingness to accept risk (risk-neutral) or avoid it (risk-averse).

Optimal Drought Management Actions For Cattle Operations On The Laguna Pueblo And Zuni Pueblo Indian Reservations, Tatiana Drugova, Kynda R. Curtis, Man-Keun Kim

All Current Publications

In this fact sheet, we examine the drought management options available to cattle operations on the Laguna Pueblo and Zuni Pueblo reservations in New Mexico. Specifically, we discuss the results of a study that evaluated the economic outcomes of two common drought response strategies: herd reduction and supplemental hay purchases. We also provide recommendations for ranchers regarding optimal strategies, i.e., those which would maximize profits, for two rancher types, differentiated by their willingness to accept risk (risk-neutral) or avoid it (risk-averse).

Optimal Drought Management Actions For Cattle Operations On The Duck Valley And Pyramid Lake Indian Reservations, Kynda R. Curtis, Tatiana Drugova, Man-Keun Kim

All Current Publications

In this fact sheet, we examine the drought management options available to cattle operations on two Native American reservations in Nevada, the Duck Valley and Pyramid Lake Indian reservations. Specifically, we discuss the results of a study that evaluated the economic outcomes of two common drought response strategies: herd reduction and supplemental hay purchases. We also provide recommendations for ranchers regarding optimal strategies, i.e., those which would maximize profits for two rancher types, differentiated by their willingness to accept risk (risk-neutral) or avoid it (risk-averse).

Credit Card Fraud Detection Using Metaheuristic Techniques, Narges Sabry Anwer Mohammed, Mohammed Sabry Saraya, Amr M. Thabet, Labib M. Labib

Mansoura Engineering Journal

Credit Card Fraud Detection (CCFD) has become a critical challenge to financial security due to increasingly sophisticated fraudulent activities. This study investigates the effectiveness of Meta-Heuristic (MHT) optimization techniques in improving fraud detection (FD) through feature selection (FS) and model optimization. To address class imbalance, Random Under-Sampling (RUS) was applied. The selected feature subsets were evaluated using three machine learning (ML) classifiers—Decision Tree (DT), KNearest Neighbours (KNN), and XGBoost (Xgb-Tree)—across four benchmark datasets: European, Statlog (Australian Credit Approval), PaySim, and Credit Card Transactions Fraud Detection (CCTFD). Eleven binary MHT algorithms were implemented and compared. The comparative analysis shows that the …

First Report Of The Chytrid Fungus, Batrachochytrium Dendrobatidis (Chytridiomycota: Rhizophydiales) From Spring Peeper, Pseudacris Crucifer (Anura: Hylidae), In Western Arkansas, C. T. Mcallister, I. F. Standish, E. M. Leis, M. R. Rodriguez, G. Burrows, H. W. Robison

Journal of the Arkansas Academy of Science

Seven adult spring peepers, Pseudacris crucifer, were collected by hand during April 2024 from Polk County, Arkansas, and examined for the pathogens, Batrachochytrium dendrobatidis (Bd), Batrachochytrium salamandrivorans (Bsal), and frog virus 3-like Ranavirus (FV3). Swabs from three of seven (43%) individuals tested positive for Bd: all P. crucifer were negative for the other two pathogens. In addition, no hosts showed any obvious pathological signs of infection and, as such, may represent Bd vectors.  This is the first time P. crucifer from Arkansas has been reported with Bd and increases the number of amphibian species …

Spatiotemporal Analysis Of Genetic Perturbations Reveals A Genetic Cascade Driving Tribolium Gap Gene Initialization, Mahla Ahmadi, Heike Rudolf, Christine Mau, Jimena Garcia-Guillen, Ezzat El-Sherif

School of Integrative Biological & Chemical Sciences Faculty Publications

The ‘French flag’ model has long served as the prevailing framework for explaining how morphogen gradients generate spatial domains during embryonic development. However, recent evidence indicates that many tissues establish patterns by translating the sequential activation of genes into spatial domains. While the sequential nature of this process is becoming clear, the mechanisms that mediate these temporal dynamics and translate them into stable spatial boundaries remain debated. Using the gap gene network in the flour beetle Tribolium castaneum [which mediates the regionalization of the anterior-posterior (AP) axis into different axial fates through the regulation of downstream Hox genes] as a …

Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy

Psychology Faculty Articles and Research

Background and aim

Methods

Radionuclide-Stimulated Dynamic Therapy Induces Complementary Immunogenic Necroptosis And Apoptosis Cancer Cell Death Pathways, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, Lemoyne Habimana-Griffin, Gail Sudlow, Julie Prior, Ezugo Onejeme, Alex Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Luke Stallings, Chidube Alagbaoso, Nathan Reed, Matthew M Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine Weilbaecher, Samuel Achilefu

Faculty, Staff and Student Publications

Radionuclide-stimulated dynamic therapy (RaST) utilizes Cerenkov-radiating radiopharmaceuticals to activate light-sensitive drugs and materials, generating reactive oxygen species (ROS) that inhibit cancer progression. However, the underlying cell death mechanisms are not fully understood. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex and radiolabeled 2-fluorodeoxyglucose, we found that RaST induced apoptosis and necroptosis, characterized by the activation of RIPK-1, RIPK-3, nuclear factor kappa B, and mixed lineage kinase domain-like pseudokinase, leading to membrane permeabilization, cytokine release, and the expression of immunogenic damage-associated molecular patterns. In immune-deficient breast tumor-bearing mice with adequate stroma and growth factors, RaST did not prevent tumor growth …