Digital Commons Network^™

Comprehensive Metabolic Profiling Across Five Lifespan Stages In Murine Hippocampus And Cortex Reveals Sex-Related Variation In Age-Related Cognitive Decline, Xi Long, Wuping Liu, Changhan Chen, Qi Guo, Yidan Wang, Fang Yu, Yujin Zhang, Rodney E Kellems, Yang Xia

Faculty, Staff and Student Publications

This study employs Barnes maze behavioral assessments, untargeted liquid chromatography-mass spectrometry metabolomics, and 13C6-glucose isotopic tracing to systematically investigate cognitive function and metabolic profiles in hippocampal and cortical tissues of male and female mice across five distinct age-ranges. Behavioral analyses reveal significant cognitive decline in both sexes by 16-months-of-age, with females exhibiting more severe impairment by 23-months, demonstrating a sex-related variation. 13C6-glucose tracing analyses reveals that glucose is rapidly and preferentially metabolized toward the Tricarboxylic acid cycle over glycolysis and the pentose phosphate pathway (PPP), with metabolism rates increasing from juvenility to meet developmental demands and maintaining homeostasis into pre-elderly. …

Pengaruh Pemberian Berbagai Dosis Curcuminoid Pada Babi Terhadap Pertumbuhan Dan Konversi Ransum (The Effect Of Ration Containing Various Dosage Curcuminoid In Pigs Rations On Growth And Ration Convertion), Sauland Sinaga, Sri Martini

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian mengenai “Pengaruh Pemberian Berbagai Dosis Curcuminoid Pada Babi Terhadap Pertumbuhan dan Konversi Ransum” dilaksanakan pada bulan Desember 2009 sampai bulan Maret 2010 di KPBI (Koperasi Peternak Babi Indonesia), Kecamatan Cisarua, Kabupaten Bandung. Tujuan penelitian ini untuk mengetahui pemberian dosis yang tepat serta pengaruh Curcuminoid sebagai bahan pakan feed additive terhadap kurva laju pertumbuhan dan angka konversi ransum. Penelitian ini menggunakan 20 ekor ternak babi periode starter berumur kurang lebih 2 bulan dengan bobot badan rata-rata 18 kg dan koefisien variasi 7,5 %. Rancangan Percobaan yang digunakan adalah Rancangan Acak Lengkap dengan empat macam perlakuan yaitu 0, 4, 8 dan …

Peningkatan Berat Akar, Berat Nodul Efektif Dan Hasil Hijauan Legum Dengan Pemberian Molibdenum Dan Inokulasi Rhizobium (Increasing Root Weight, Nodule Weight Effectively And Fresh Forage Of Legumes By Adding Molybdenum Fertilizer And Rizobium Inoculation, Iin Susilawati, Nyimas Popi Indriani, Herryawan Kemal Mustofa, Ana Rochana Tarmidi

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini dilakukan untuk mengkaji pengaruh pemberian molibdenum dan inokulasi rhizobium terhadap berat akar, berat nodul efektif dan hasil  hijauan legum. Rancangan percobaan menggunakan Rancangan Acak Lengkap (RAL) pola faktorial 3 faktor (4 x 2 x 2) dengan 2 kali ulangan. Faktor pertama yaitu jenis legum terdiri atas 4 jenis yaitu Siratro (Macroptilium atropurpureum), Kudzu (Pueraria phaseoloides), Sentro (Centrosema pubescens) dan Kalopo (Calopogonium mucunoides), faktor kedua molibdenum terdiri atas  2 taraf (m0 = tanpa molibdenum, m1 = dengan molibdenum, 6 g kg-1 benih) dan faktor ketiga inokulasi rhizobium terdiri atas dua taraf (r0 = tanpa inokulasi rhizobium; r1 = dengan …

Respon Broiler Terhadap Pemberian Ransum Mengandung Dedak Padi Fermentasi Oleh Kapang Aspergillus Ficuum (Response Of Broiler Fed On Diet Containing Fermented Rice Bran By Aspergillus Ficuum), Siti Wahyuni H.S., Dwi Cipto Budinuryanto, H. Supratman

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian bertujuan untuk mengetahui respon broiler terhadap pemberian ransum mengandung dedak padi hasil fermentasi oleh Aspergillus ficuum yang diukur melalui konsumsi ransum, pertambahan bobot badan, konversi ransum, persentase karkas dan imbangan efisiensi protein.  Penelitian menggunakan 300 ekor ayam broiler final stock Arbor Acres yang dibagi ke dalam 30 plot.  Ransum disusun iso-protein dan iso-energi dengan kandungan protein kasar 22% dan energi metabolis 3100 kkal/kg.  Penelitian dilakukan secara eksperimen menggunakan Rancangan Acak Lengkap , terdiri atas 6 ransum sebagai perlakuan setiap perlakuan diulang 5 kali.  Ransum perlakuan terdiri atas R0 (0% dedak padi fermentasi), R1 (5% dedak padi fermentasi), R2 (10% …

Studi Pembuatan Kompleks Mineral-Minyak Dan Efek Penggunaannya Dalam Ransum Terhadap Fermentabilitas Dan Kecernaan (In Vitro) (Study Of Oil-Mineral Complex And It Effects On In Vitro Fermentability And Digestibility), U. Hidayat Tanuwiria, Dwi Cipto Budinuryanto, S. Darodjah, Wendry Setiyadi Putranto

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian bertujuan untuk mengetahui fermentabilitas dan kecernaan ransum yang mengandung berbagai kompleks minyak-mineral in vitro.  Penelitian dilakuan secara eksperimen dengan Rancangan Acak Lengkap (RAL) empat perlakuan dan lima ulangan. Percobaan pertama terdiri atas R1 = Ransum lengkap + 5% Minyak Jagung, R2 = Ransum lengkap + 5,95% Kompleks Ca-Minyak Jagung, R3 = Ransum lengkap + 5,95% Kompleks Ca-Minyak Kacang Tanah, R4 = Ransum lengkap + 5,95% Kompleks Ca-Minyak Ikan. Perlakuan kedua : R1 = Ransum lengkap + 5% Minyak Kacang Tanah. R2 = Ransum lengkap + 5% Kompleks I-Minyak Jagung, R3 = Ransum lengkap + 5% Kompleks I-Minyak Kacang Tanah, …

Isolasi Yeasts Dari Daging Dan Potensinya Sebagai Agen Biopreservasi Dan Pewarna Makanan (Isolation Of Yeasts From Meat And Its Potential As Bio Preservation Agent And Food Coloring), Wendry Setiyadi Putranto, Roostita L. Balia, Obin Rachmawan, Eka Wulandari

Jurnal Ilmu Ternak Universitas Padjadjaran

Yeasts merupakan mikroba potensial untuk dikembangkan sebagai penghasil komponen bioaktif seperti enzim, antimicrobial agent sebagai biopreservasi, serta pengahasil pewarna makanan (pigment).  Penelitian merupakan studi ekploratif potensi yeasts yang diisolasi dari daging ayam dan sapi. Ditemukan isolate yeasts yang memiliki karakteristik spesifik dengan warna merah.  Jumlah total yeasts pada daging ayam 2.105 cfu/gram sedangkan pada daging sapi 1.105 cfu/gram. Hasil pemurnian isolate  diperoleh dua isolate yang memiliki kemampuan daya hambat yang terhadap Pseudomonas aerugenes dan Staphylococus aureus serta tidak meiliki aktivitas penghambatan terhadap Escherichia coli dan Candida albicans. pH akhir media selama fermentasi 25 0C, 48 jam adalah 5,5 dan 5,6 …

Karakteristik Stirred Yoghurt Mangga (Mangifera Indica) Dan Apel (Malus Domestica) Selama Penyimpanan (Characteristics Of Mango (Mangifera Indica) And Apple (Malus Domestica) Sittted Yoghurt During Storage), Eka Wulandari, Wendry Setiyadi Putranto

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan jus buah mangga dan apel terhadap  keasaman, total bakteri dan sineresis stirred yoghurt mangga dan apel yang dihasilkan dan selama proses penyimpanan. Penelitian ini dilakukan dengan tiga perlakuan yaitu stirred yoghurt mangga, stirred yoghurt apel dan kontrol. Stirred yoghurt yang dihasilkan disimpan selama 7 hari. Hasil penelitian menunjukkan stirred yoghurt mangga (210 menit, pH=4,3) dan apel (210 menit, pH=4,2) terkoagulasi lebih cepat dan pada pH yang lebih rendah dibandingkan dengan control (250 menit, pH=4,4). Selama penyimpanan kadar asam laktat dan jumlah bakteri asam laktat lebih tinggi pada stirred yoghurt mangga dan apel dibandingkan …

Deteksi Jumlah Bakteri Total Dan Koliform Pada Lumpur Hasil Ikutan Pembentukan Gasbio Dari Feses Sapi Perah (Detection Total Bacteria Amount And Coliform In Sludge Biogas From Dairy Cattle Feces), Yuli Astuti Hidayati, Ellin Harlia, Eulis Tanti Marlina

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini dilaksanakan di laboratorium Mikrobiologi dan Pengolahan Limbah Fakultas Peternakan universitas padjadjaran. Tujuan penelitian ini adalah untuk mengetahui jumlah total bakteri dan koliform pada lumpur hasil ikutan pembentukan gasbio dari feses sapi perah. Penelitian dilakukan dengan metode eksplorasi pada peternak sapi perah yang membuat instalasi gasbio di desa Haurngombong, Kecamatan Pamulihan-Sumedang. Hasil penelitian menunjukkan jumlah bakteri total adalah 41,82 x 1012 cfu/ml lumpur, sedangkan jumlah 8,23 MPN/ml lumpur. Kata kunci : bakteri total, koliform, lumpur, gasbio, feses sapi perah.

Peran Usaha Perbibitan Dalam Pengembangan Ternak Sapi Perah Di Indonesia (The Role Of Breeding Farm On Dairy Cattle Development In Indonesia), Achmad Firman, Sri Bandiati Komar Prajoga

Jurnal Ilmu Ternak Universitas Padjadjaran

Usaha perbibitan pada peternakan sapi perah memegang peranan penting dalam penyediaan stock bibit sapi perah. Dalam kerangka budidaya sapi perah, perbibitan atau breeding merupakan bagian yang tidak terpisahkan dari siklus feeding, breeding, dan management. Ke tiga faktor tersebut sangat penting dalam usahaternak sapi perah. Tujuan dari kajian ini adalah untuk mengetahui sejauhmana peran perbibitan dan program-program perbibitan dalam penyediaan ternak pengganti, dan untuk mengetahui berapa besar investasi yang diperlukan dalam usaha perbibitan sapi perah. Metode yang dilakukan pada kajian ini adalah kajian pustaka yang dititikberatkan pada usaha perbibitan sapi perah. Hasil penelitian menunjukkan bahwa berdasarkan hasil mapping terhadap peran pelaku …

Pengaruh Penggunaan Asam Sulfat (H2so4) Dan Asam Formiat (Hcooh) Pada Proses Pikel Terhadap Kualitas Kulit Jadi (Leather) Domba Garut (The Effect Of Sulfuric Acid (H2so4) And Formic Acid (Hcooh) In Pickle Process On Garut Sheep Leather Quality), Jajang Gumilar, Wendry Setiyadi Putranto, Eka Wulandari

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan berbagai tingkat asam sulfat (H2So4) dan asam formiat (HCOOH) pada proses pikel  terhadap kualitas kulit jadi (leather) Domba Garut. Kualitas Kulit jadi didasarkan pada kadar keasaman (pH), kadar krom (Cr2O3), dan kadar air (H2O). Penelitian ini dilakukan secara eksperimen menggunakan pola faktorial dengan rancangan dasar rancangan acak lengkap, menggunakan 48 lembar kulit Domba Garut jantan ukuran 90. Kulit-kulit tersebut dibagi kedalam 16 kelompok. Tiap-tiap kelompok diberikan perlakuan penggunaan asam sulfat dan asam formiat. Masing-masing kelompok diulang sebanyak 3 kali ulangan. Hasil penelitian ini menunjukkan bahwa penggunaan berbagai tingkat asam sulfat (H2So4) dan asam …

Pengaruh Suplemen Zn-Proteinat, Cu-Proteinat Dan Kompleks Ca-Minyak Ikan Dalam Ransum Berbasis Pucuk Tebu Amoniasi Terhadap Performans Domba Jantan Persilangan Priangan X Barbados, U. Hidayat Tanuwiria, Budi Ayuningsih

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan mempelajari pengaruh suplemen Zn-Proteinat, Cu-Proteinat dan Ca-Minyak dalam ransum berbasis pucuk tebu diamoniasi terhadap pertumbuhan dan efisiensi ransum pada domba jantan persilangan Priangan x Barbados. Percobaan dilakukan terhadap 5 ekor domba jantan yang sedang tumbuh dengan menggunakan rancangan Bujur Sangkar Latin (BSL) 5x5,  lima macam ransum yaitu R1 = campuran 50% pucuk tebu amoniasi + 50% konsentrat, R2 = R1 + 2% Zn-proteinat, R3 = R1 + 2% Cu-proteinat, R4 = R2 + 2% Cu-proteinat, dan R5 = R4 + Ca-minyak ikan. Hasil yang diperoleh menunjukkan bahwa pemberian Zn-proteinat, Cu-proteinat dan komplek  Ca-minyak tidak mempengaruhi konsumsi ransum, …

Potensi Pakan Serat Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Kabupaten Garut, U. Hidayat Tanuwiria, A. Yulianti, A. Mushawwir

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Garut. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Garut adalah 414.211,1 ton bahan kering (BK) yang terdiri atas 151.395,6 ton BK asal rumput dan 262.815,5 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 124.706 satuan ternak (ST), yang terdiri atas 45.580,5 ST ternak ruminansia kecil dan 79.125,5 ST ternak ruminansia besar.

Kata Kunci …

Potensi Pakan Asal Limbah Tanaman Pangan Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Sumedang (Agriculture By Product As Potential Feed And Its Carrying Capacity In Sumedang), U. Hidayat Tanuwiria, N. Mayasari, A. Yulianti

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Sumedang. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Sumedang adalah 284.784,72 ton bahan kering (BK) yang terdiri atas 86.937,65 ton BK asal rumput dan 197.847,07 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 85.739,79 satuan ternak (ST), yang terdiri atas 26.174,21 ST ternak ruminansia kecil dan 59.565,58 ST ternak ruminansia besar. Potensi protein …

Pemanfaatan Gelatin Tepung Sagu (Metroxylon Sago) Sebagai Bahan Pakan Ternak Ruminansia (Utilization Of Sago (Metroxylon Sago) Gelatin As Feed Ruminant), Harry Triely Uhi

Jurnal Ilmu Ternak Universitas Padjadjaran

Telah dilakukan penelitian pemanfaatan gelatin sagu sebagai bahan pakan ternak ruminansia. Tujuan penelitian untuk mengetahui suhu, waktu dan ratio volume air yang tepat selama pemanasan sampai terbentuknya gelatinisasi. Justifikasi terjadinya proses gelatinisasi didasarkan atas rusaknya bentuk granula yang dilihat dengan  mikroskop elektron dan mikroskop polarisasi. Perlakuan yang digunakan R1 (Tepung sagu 100 gram + suhu   80 ⁰C); R2 (Tepung sagu 100 gram + suhu   85 ⁰C); R3 (Tepung sagu 100 gram + suhu   90 ⁰C); R4 (Tepung sagu 100 gram + suhu   95 ⁰C); dan R5 (Tepung sagu 100 gram + suhu 100 ⁰C). Parameter …

Pengaruh Tepung Cangkang Rajungan (Portunus Pelagicus) Sebagai Sumber Kitin Dalam Ransum Terhadap Kandungan Lemak Feses Dan Efisiensi Pakan Tikus Putih (Rattus Norvegiccus) Strain Wistar (The Effect Of Crabs Shells (Portunus Pelagicus) As A Source Of Chi, Muhamad Fatah Wiyatna, Irba U. Warsono, Aminuddin Parakkasi

Jurnal Ilmu Ternak Universitas Padjadjaran

Cangkang rajungan mengandung kitin yang persentasenya paling besar berupa polisakarida. Kitin dan derivat-derivatnya telah banyak digunakan dalam berbagai keperluan terutama untuk kesehatan. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pemberian tepung rajungan sebagai sumber kitin terhadap efisiensi pakan dan kandungan lemak feces tikus putih Rattus norvegicus) strain Wistar. Penelitian menggunakan rancangan acak lengkap pola faktorial 2x5 dengan tiga kali ulangan. Faktor pertama adalah jenis kelamin dan kedua level tepung rajungan yaitu 0%, 5%, 10%, 15%, and 20%. Hasilnya penelitian menunjukkan tidak ada interaksi antara jenis kelamin dengan kandungan teung rajungan dalam ransum. Kandungan lemak dalam feces tertinggi diperoleh …

Pengaruh Lama Penyimpanan Semen Cair Ayam Buras Pada Suhu 5 0c Terhadap Periode Fertil Dan Fertilitas Sperma (The Storage Time Effect Of The Local Chicken Chilled Semen At 5 0c On Fertility And Fertile Period Of Sperm), Nurcholidah Solihati, Ruhijat Idi, Rangga Setiawan, I.Y. Asmara

Jurnal Ilmu Ternak Universitas Padjadjaran

Tujuan penelitian ini untuk mengetahui sejauh mana pengaruh lama penyimpanan semen cair ayam buras pada suhu 5⁰C terhadap periode fertil dan fertilitas sperma.  Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan setiap perlakuan diulang 6 kali.  Lama penyimpanan yang digunakan dalam penelitian ini adalah penyimpanan 1 jam (0 hari), 24 jam (1 hari) dan 48 jam (2 hari).  Peubah yang diukur adalah periode fertil dan fertilitas sperma. Data yang diperoleh dianalisis dengan analisis sidik ragam, dan untuk mengetahui perbedaan antar perlakuan diuji dengan menggunakan uji jarak berganda Duncan. Hasil penelitian menunjukan bahwa lama penyimpanan semen …

Modulation Of Hypothalamic–Limbic Circuits Regulating Appetite In Response To Health Lifestyle In Obese Adults, Nour Shakir Rezaieg, Muthanna M. Awad

Karbala International Journal of Modern Science

Background: Overeating leads to obesity a low-grade inflammatory disease. In this context, aguati-related neuropeptide (AgRP) and ghrelin are pivotal players in appetite regulation, while chemerin is an adipose tissue-secreted adipokine that contributes to low-grade inflammation associated with obesity. Objective: This study used a healthy lifestyle program designed for each obese participant to identify diet-related neuro-hormonal changes in appetite regulation. Design, Setting, and Participants: This a longitudinal quasi-experimental controlled study was conducted from 1^st December 2024, to 30^th July 2025, at University of Anbar. The sample included 100 participants, 50 obese (weight between 100–140 kg) and 50 healthy participants …

Evaluation Of Mcf-7 Breast Cancer Cell Cytotoxic And Antioxidant Activities Of Peptide Fractions From Symbiotic Bacteria Of Jellyfish Catostylus Sp., Eka Sry Wahyuni, Ahyar Ahmad, Muhammad Nasrum Massi, Sofa Fajriah, Randi Rimpung, Muh. Akbar Ardiputra, Harningsih Karim, Irda Handayani

Karbala International Journal of Modern Science

Marine-derived symbiotic microorganisms are recognized as a promising source of bioactive compounds with potential therapeutic applications, yet research on jellyfish-associated bacteria remains limited. This study examines the bioactivity of peptide fractions derived from symbiotic bacteria isolated from the jellyfish Catostylus sp., collected from the coastal waters of South Sulawesi, Indonesia, with a focus on their anticancer and antioxidant properties. Following sample collection, the symbiont bacteria were isolated, enzymatically hydrolyzed, and purified before their biological activity was evaluated. Preliminary cytotoxicity screening using the brine shrimp lethality assay revealed that the extracellular peptide fraction (5–10 kDa) and intracellular peptide fraction (3–5 kDa) …

20% Caloric Restriction Did Not Impact Bone Health Nor Exercise-Induced Elevations In Bone Mass In Young Female Rats, Ken D. Sumida, Brady Slater, Haley Folta, Kassandra Lee, Sarina Karwande, Quinton Wong, S. Victoria Jaque, Frank Frisch

Health Sciences and Kinesiology Faculty Articles

The purpose of this study was to determine if a 6-week 20% caloric restrictive (CR) diet, with or without resistance training, would impact bone health in growing young female rats. Forty female rats (~ 5 wks old) were randomly divided into the following groups: baseline (n = 8), sedentary fed a normal diet (N, n = 8), sedentary fed a 20% CR diet (D, n = 8), resistance trained fed a normal diet (NT, n = 8), and resistance trained fed a 20% CR diet (DT, n = 8). The exercise groups were conditioned to climb a vertical ladder …

Glutamatergic Projection Neurons In The Basal Forebrain Underlie Learned Olfactory Associational Valence Assignments, Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Qingchun Tong, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Sensory perception is shaped by experience, giving stimuli behavioral significance. Basal forebrain (BF) cholinergic neurons in mice, which are crucial for arousal and motivation, also regulate sensory processing. Within BF nuclei, glutamatergic (vGlut2BF) neurons receive cholinergic input and modulate behaviors, but their roles in encoding sensory significance remain unclear. Using in vivo calcium imaging, we found that vGlut2BF neurons initially poorly encoded odor identity. However, their response to conditioned odors increased following associative learning, and their population activity more distinctly encoded paired stimuli, reflecting emergent value representation. Furthermore, pairing stimulation or inhibition of vGlut2BF neurons with specific odors altered odor …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Ali Dadbin, Andrea Ruiz-Jurado, Parag A Parekh, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Brain Gains: A Review Of Remediation Treatment Strategies Using Exercise Following Traumatic Brain Injury, Jessica Smith, Kristin Biggins, Loriann Helgeson

The Open Journal of Occupational Therapy

In this Opinions in the Profession article, we explore remediation treatment strategies using exercise for recovery from post-traumatic brain injury and aim to justify the use of such treatment in the occupational therapy profession to increase skills for functional gain. Common treatment strategies used by occupational therapists after brain injury are compensatory strategies, indicating the client learns a new way to perform the task. Though effective, it is also necessary to consider how remediation and neuroplasticity are essential. Teaching new approaches to complete tasks results in functional gains; however, focusing on foundational skills using exercises to relearn motor patterns to …

Research Progress In Antagonistic Bacteria Against Staphylococcus Aureus, Caiqi Wang, Yuansong Ma, Xinrui Zhao, Pei Zhou, Sifan Lu, Yuxin Li, Yinbiao Xu

Journal of Food Science and Biotechnology

Staphylococcus aureus,a common Gram-positive foodborne pathogen,is ubiquitous in the human skin and respiratory tract.It can cause pneumonia,pleurisy,endocarditis,food poisoning,sepsis and other infectious diseases.The widespread and long-term use of antibiotics has aggravated the antibiotic resistance of Staphylococcus aureus.In particular,the emergence of multi-drug resistant strains has greatly reduced the therapeutic effect.Therefore,developing new antibacterial means to replace or assist existing antibiotics has become an urgent need.Microbial natural products are important resources for the development of new antibiotics,and antagonistic microorganisms play an important role.This paper reviewed the species of antagonistic bacteria against Staphylococcus aureus,the types of antibacterial active substances,and the commonly used screening methods of …

Cyanidin- 3-Glucoside Ameliorates Ocular Surface Dysfunction In Rats With Dry Eye Disease, Ke Zhang, Ziyu Liu, Zhangben Yao, Peng Zhang, Lei Tian, Ying Jie, Yong Wang

Journal of Food Science and Biotechnology

[Objective ] Studies have shown that cyanidin- 3-glucoside (C3G),the main component of black rice anthocyanins,exhibits protective effects on retina and retinal pigment epithelium (RPE ) cells.However,there is a lack of in vivo evidence regarding the efficacy of C 3G in alleviating dry eye disease (DED ),which limits its application in ocular surface disorders.This study aims to investigate the protective effects of C 3G on DED in rats.[Method ] 24 Wistar rats were randomly assigned into control,model,and C 3G groups.In model and C 3G groups,a DED model was established by subcutaneous injection of scopolamine hydrobromide (4 times daily for 28 d).The …

Ultrasound-Assisted Enzymatic Transformation And Immune Efficacy Of Black Ginseng Saponins, Kuo Wang, Bao Zhong, Mingran Luan, Fenglin Li, Zhongkui Lu, Guanran Wang, Kun Yao

Journal of Food Science and Biotechnology

[Objective ] This study aims to elucidate the transformation process of black ginseng saponins and their immunomodulatory mechanisms.[Method ] An ultrasound-assisted enzymatic method was employed for the transformation of black ginseng saponins,and the mass concentration of black ginseng saponins was determined.Furthermore,the immunomodulatory effects of black ginseng saponins were investigated through animal experiments.[Result ] Under the conditions of an enzymatic hydrolysis temperature of 40 ℃,an enzyme mass fraction of 8%,enzymatic hydrolysis time of 60 min,and ultrasonic treatment time of 25 min,the mass concentration of black ginseng saponins increased from 1 615.40 μg/mL to 3 351.38 μg/mL,which represented an increase of 107.47%.The …

Degradation Of Nutrients In Corn Steep Liquor By Aspergillus Oryzae And Absorption Characteristics Of The Product, Xiaojie Wang, Chunrong Xia, Xiaolan Liu

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the degradation patterns of nutrients in corn steep liquor by Aspergillus oryzae and the absorption characteristics of the product.[Method ] Aspergillus oryzae was used for the fermentation of corn steep liquor,and degradation patterns of nutrients were studied after fermentation for 1,3,5,7,9,and 11 d.Changes in amino acid mass fraction and peptide molecular mass distribution in corn steep liquor after fermentation for 7 d were measured.Furthermore,the resting cells of Auricularia heimuer mycelia were used to explore the absorption characteristics of the fermentation product of corn steep liquor.[Result ] As the fermentation time prolonged within 1~7 …

Nitrogen Dynamics And Use Efficiency In Pasture-Based Grazing Systems: A Synthesis Of Ecological And Ruminant Nutrition Perspectives, Bashiri Iddy Muzzo

Wildland Resources Student Research

Pasture-based ruminant systems link nitrogen (N) nutrition with ecosystem N cycling. Grazing ruminants convert fibrous forages into milk and meat but excrete 65 to 80% of ingested N, creating excreta hotspots that drive ammonia volatilization, nitrate leaching, and nitrous oxide (N₂O) emissions. This review synthesizes ecological and ruminant nutrition evidence on N flows, emphasizing microbial processes, biological N₂ fixation, plant diversity, and urine patch biogeochemistry, and evaluates strategies to improve N use efficiency (NUE). We examine rumen N metabolism in relation to microbial protein synthesis, urea recycling, and dietary factors including crude protein concentration, energy supply, forage …

C Elegans As A Tractable Infection Model For The Emerging Fungal Pathogen Candida Auris, Melissa Martinez, Melissa R Cruz, Danielle A Garsin, Michael C Lorenz

Faculty, Staff and Student Publications

Candida auris is an emerging multidrug-resistant fungal pathogen. The genetic factors contributing to the virulence, drug resistance, and stress-tolerant nature of C. auris are mostly unknown. Additional animal models of virulence are needed, especially those amenable to high-throughput analysis. The nematode Caenorhabditis elegans has been validated as an effective tool for studying multiple fungal and bacterial pathogens. We describe here a C. elegans infection model in which exposure to C. auris is lethal to worms with kinetics similar to killing by Candida albicans; in contrast to C. albicans, C. auris does not form hyphae, indicating distinct virulence mechanisms. …

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …

A055: Aerobic Exercise Improves Sarcopenia And Gut-Muscle Axis In Abx-Treated Samp8 Mice, Sisi Yao, Wenfeng Liu

International Journal of Physical Activity and Health

Sarcopenia, characterized by reduced skeletal muscle mass and function, is a common geriatric condition that impairs mobility and quality of life. Its causes include neuroendocrine dysregulation, chronic inflammation, malnutrition, and gut microbiota imbalance. The gut microbiota influences muscle metabolism and function via the gut-muscle axis, and aerobic exercise has been shown to improve both gut microbiota composition and muscle function. This study explores whether aerobic exercise can alleviate sarcopenia induced by gut microbiota dysbiosis through the gut-muscle axis, offering a basis for exercise interventions. The study employed the senescence-accelerated mouse strain P8 (SAMP8) model. Gut microbiota dysbiosis was induced via …