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Experimental Data Extraction And In Silico Prediction Of The Estrogenic Activity Of Renewable Replacements For Bisphenol A., Huixiao Hong, Benjamin G Harvey, Giuseppe R Palmese, Joseph F. Stanzione Iii, Hui Wen Ng, Sugunadevi Sakkiah, Weida Tong, Joshua M Sadler

Henry M. Rowan College of Engineering Departmental Research

Bisphenol A (BPA) is a ubiquitous compound used in polymer manufacturing for a wide array of applications; however, increasing evidence has shown that BPA causes significant endocrine disruption and this has raised public concerns over safety and exposure limits. The use of renewable materials as polymer feedstocks provides an opportunity to develop replacement compounds for BPA that are sustainable and exhibit unique properties due to their diverse structures. As new bio-based materials are developed and tested, it is important to consider the impacts of both monomers and polymers on human health. Molecular docking simulations using the Estrogenic Activity Database in …

Avalanche Isfet Sensing Chip For Dna Sequencing, Mohammad Uzzal

Electrical and Computer Engineering ETDs

DNA sequencing is a fundamental tool for biological science, aimed primarily at uncovering the genetic contributions to diseases. The first Human DNA sequence, which employed conventional fluorescent-based Sanger Sequencing method, took many years to complete at a cost of over three billion dollars. In one survey, it shows that Human Genome Project (HGP) had generated more than $67 billion in U.S. economic output, $20 billion in personal income for Americans and 310 thousand jobs in USA, only during year 2010. The HGP has increased the need for high-throughput, low cost, fast, accurate and inexpensive DNA sequence technique. This demand has …

Plant-Based Technologies To Enable Rapid Response To Ebola Outbreak, Jerzy Karczewski, Vidadi Yusibov

Vaccine Technology VI

Ebola is a rare and deadly disease caused by infection with a strain of Ebola virus (Zaire, Sudan or Marburg). Ebola is spread through a direct contact with body fluids of infected patients. The recent Ebola outbreak affected multiple countries in West Africa and clearly demonstrated a need for development of technologies enabling production of adequate supply of vaccines and therapeutics to treat infected patients. We have undertaken efforts to develop methods and produce plant-based recombinant vaccine as well as a series of monoclonal antibodies to fight Ebola infection.

Several approaches were carried out to develop vaccines based on recombinant …

Air Mobility Future: Evolving Command And Control Relationships In The Information Age, Ian M. Slazinik

Theses and Dissertations

This research paper analyzes information flow through theater Air Mobility Command and Control (C2) organizations. The purpose is to uncover guidelines going forward to adapt organizational structure and processes to increase the speed and reach of information. These guidelines could assist with improving organizational agility and decision making while adapting to future trends in the broader C2 enterprise. To collect data, the researcher conducted interviews with seventeen C2 experts with experience at various levels of C2, from worldwide to theater Air Mobility C2 organizations, from Air Mobility C2 leadership, to experts in non-mobility C2 divisions. Interview subjects shared their perceptions …

Design, Construction, And Evaluation Of A Gas Forge, Spencer M. Davis

BioResource and Agricultural Engineering

This report covers the design, construction, and evaluation of a propane forge. The purpose for building this propane forge was to replace an old charcoal forge in order to improve upon certain points of performance such as adjustability of heat, portability, and fuel cost by being able to run the forge for any amount of time with an easy on/off control. The design of this forge consisted of a steel pipe body insulated with ceramic fiber blanket, and was heated by a single atmospheric burner.

Psychological Health Outcomes Within Usaf Remotely Piloted Aircraft Support Career Fields, Kris Anthony Ostrowski

Doctoral Dissertations and Master's Theses

Remotely piloted aircraft are now commonplace in modern warfare. Enlisted intelligence personnel in the U.S. Air Force (USAF) who support these activities have reported personal accounts of posttraumatic stress and fatigue, possibly due to viewing high-definition, full-motion-video, remote warfare. Rates of mental health diagnoses and counseling are unknown in this population. Incidence rates of 12 specific mental health outcomes were calculated for all enlisted active duty USAF Intelligence Specialists in the 1N1 and 1N0 career fields from 1 January 2006 through 31 December 2010, while considering various demographic and military variables. The incidence rates were compared to RPA sensor operators …

Analysis Of Electromagnetic Launcher Design And Modeling, Garrett Ross Germany

Master's Theses

This thesis derives working expressions from electromagnetic physical laws to gain a deeper understanding of the nature of railguns. The expressions are refined for ease of use and then compared to electromagnetic simulators that solve complex equations that arise from different rail geometry. Further simplifications lead to an expression for the final velocity of the projectile and showcase the importance of the system resistance to projectile flux gain ratio. A Simulink simulation then incorporates the resulting non-linear differential equations and approximates the projectile velocity over time based on physical dimensions and material properties. Some equations derived can be found in …

Infrared Imaging - Case Studies And Applications, Shuang Du

Theses

Recent advancements in the manufacture of solid state detectors have led to significant improvements in the use and applications of infrared (IR) imaging. Compared with traditional imaging in visible light, infrared imaging has abilities to convey significant additional information. Applications in medicine require wavelengths in the range of 0.8 to 25 microns while metrology and astronomy, traditionally, require wavelengths in the range of 25 microns to 1 mm.

In this study, infrared imaging has been used as a tool to characterize a variety of objects and systems. Some of these case studies have been considered under conditions of thermodynamic non-equilibrium. …

Scalable Three-Dimensional Grasping Mechanism, Ikya Mamidala

Master of Technology Management Plan II Graduate Projects

In this work, we develop a scalable end-effector mechanism for grasping three- dimensional objects with sizes ranging from micrometer to millimeter scale. The design architecture of the gripper comprises an array of identical fingers patented in a circular fashion. Each finger is designed from a novel linkage mechanism whose end effector is manipulated by two independent actuators. In this research, we study three finger gripper device, where each is obtained from a 3 - linkage mechanism. The device is controlled by three independent piezo actuators, and one electro-magnetic solenoid common to each mechanism. The gripping capability depends on how fingers …

Using Value-Focused Thinking For Engineered Resilient Systems, Colin A. Small

Industrial Engineering Undergraduate Honors Theses

The DoD needs their systems to be resilient in the face of an ever changing world. To increase resilience in future systems the DoD has created a program called Engineered Resilient Systems. Resilience can be broken down into two parts, mission and platform resilience. Mission resilience is the ability of a system to repel, resist, absorb, and recover from environments and threats that occur on planned missions. Platform resilience is the ability of a system platform to adapt to new missions and new threats.

The University of Arkansas department of Industrial Engineering is working for the ERS program researching resilience. …

Finite Element Based Cross-Sectional Buckling Optimization For A Constant Area, Pinned-Pinned Composite Column, Anirudh Srinivas

Mechanical and Aerospace Engineering Theses - Archive

In archery, dynamic buckling compromises the target accuracy of arrows. For both dynamic and quasi-static buckling, the buckling load depends on the cross-sectional area moment of inertia, which can be increased by modifying the cross-sectional shape of the arrow shaft. Arrows commercially available today are made up of composite materials and have a tubular circular cross-section. In this study an effort has been made to optimize the cross-sectional shape of the composite arrow shaft, using finite element based, quasi-static buckling analysis keeping the length and area of the cross-section constant. The composite column is pinned at both ends and is …

Computational Analysis Of Blast Induced Damage On Neurons In Brain During Traumatic Brain Injury, Divya Swamy Bandaru

Mechanical and Aerospace Engineering Theses - Archive

Concussions are the most common kind of brain injuries, they are also called as mild Traumatic Brain Injuries (mTBI). In recent times, mTBIs are perceived as one of the major health problems faced by millions across the world. TBIs occur when there is a sudden acceleration or deceleration force is applied on the human brain that is encapsulated in the skull. When blasts caused by typical IEDs (induced by explosives) in wars propagate through the head, cavitation bubbles are formed in the brain tissue. When these bubbles collapse, they form cavitation-induced shock wave. It has been found that the strains …

Ism S-Band Cubesat Radio Designed For The Polysat System Board, Craig Lee Francis

Master's Theses

Cal Poly’s PolySat CubeSat satellites have begun to conduct more complex and scientifically significant experiments. The large data products generated by these missions demonstrate the necessity for higher data rate communication than currently provided by the PolySat UHF radio. This thesis leverages the proliferation of consumer wireless monolithic transceivers to develop a 250kbps to 2000kbps, 2W CubeSat radio operating within the 2.45GHz Industrial, Scientific, and Medical (ISM) radio band.

Estimating a link budget for a realistic CubeSat leads to the conclusion that this system will require a large deployable CubeSat antenna, large earth station satellite dish, and a fine-pointing attitude …

An Energy-Efficient Semi-Partitioned Approach For Hard Real-Time Systems With Voltage And Frequency Islands, Jesse W. Patterson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Embedded devices are computer systems with a dedicated function, such as kitchen appliances, electronic toys, phones, et cetera. Embedded devices are commonplace, and many are expected to respond to users in real-time. Such devices are often categorized as real-time embedded systems as they differ from other embedded systems in that work performed by a real-time embedded system must be scheduled such that timeliness can be provided to the user (e.g. when someone is talking on a phone, the phone needs to be able to schedule the sending and receiving of data in a timely manner such that the conversation is …

High Power Rocket Design Report, Laura E. Calcara, Monica Fernandez, Chris Green, Trent Hosokawa

Honors Thesis

Highpower rockets are extremely sensitive systems that require precise planning, testing, and analysis in order to yield accurate results. Under the guidance of project advisor, Dan Larson, a highpower rocket was designed and built to reach an apogee of 3000 feet. Additionally, means of dual deployment was used in order to aid in the safe descent and recovery of the rocket. In order to meet this expectation, two parachutes were used in conjunction with black powder ejection charges. Compliance with the safety standards of NAR and NFPA was met for the ejection system used in dual deployment. To ensure that …

Program And Proceedings: Nebraska Academy Of Sciences 1880–2016, 136th Anniversary Year, One Hundred-Twenty-Sixth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Chemistry and Physics

Collegiate Academy: Biology

Earth Science

Biological and Medical Sciences

Anthropology

Collegiate Academy: Chemistry and Physics

Environmental Sciences

Aeronautics and Space Science, Poster Session

Maiben Memorial Lecture: Juliane Soukup, “Riboswitches Turn Students onto Research” Teaching of Science and Mathematics

Applied Science and Technology

History and Philosophy of Science

Chlorination And Selective Vaporization Of Rare Earth Elements, Daniel Gaede

Graduate Theses & Non-Theses

No abstract provided.

Section Abstracts: Biomedical And General Engineering

Virginia Journal of Science

Abstracts of the Biomedical and General Engineering Section for the 94th Annual Virginia Academy of Science Meeting, May 18-20, 2016, at University of Mary Washington, Fredericksburg, VA.

Examining American Attitudes On The Use Of Military Drones, Todd Brandon

Political Science Theses and Capstones

Recent polls have revealed that Americans of both the political left and right support the use of military drones. This statement stands true among groups who traditionally do not support the use of military force. I hypothesize that people of a more liberal persuasion will be more concerned with whether or not the drone program endangers innocent civilians, while those of a more conservative view will be more concerned with the legality of conducting military drone strikes. I analyze data obtained from the Pew Research Center to examine people's attitudes on military drone strikes via framing theory. My hypothesis has …

Ramifications Of Projectile Velocity On The Ballistic Dart Penetration Of Sand, Peter Anthony Sable

Master's Theses (2009 -)

With the advent of novel in-situ experimental measurement techniques, highly resolved quantitative observations of dynamic events within granular media can now be made. In particular, high speed imagery and digital analysis now allow for the ballistic behaviors of sand to be examined not only across a range of event velocities but across multiple length scales. In an attempt to further understand the dynamic behavior of granular media, these new experimental developments were implemented utilizing high speed photography coupled with piezo-electric stress gauges to observe visually accessible ballistic events of a dart penetrating Ottawa sand. Projectile velocities ranged from 100 to …

Visual-Ins Using A Human Operator And Converted Measurements, Turner J. Montgomery

Theses and Dissertations

A method human operated INS aiding is explored in which the pilot identifies and tracks a ground feature of unknown position over a short measurement epoch using an E/O sensor. One then refers to Visual-INS. In contrast to current research trends, a human operator is entrusted with visually tracking the ground feature. In addition, a less conventional measurement linearization technique is applied to generate “converted” measurements. A linear regression algorithm is then applied to the converted measurements providing an estimate of the INS horizontal velocity error and accelerometer biases. At the completion of the measurement epoch, the INS is corrected …

Heterogeneous Air Defense Battery Location: A Game Theoretic Approach, Nicholas T. Boardman

Theses and Dissertations

The Unites States and its allies confront a persistent and evolving threat from missile attacks as nations around the world continue to invest and advance their current capabilities. Within the air defense context of a missile-and-interceptor engagement, a challenge for the defender is that surface to air interceptor missile batteries often must be located to protect high-value targets dispersed over a vast area, subject to an attacker observing the disposition of batteries prior to developing and implementing an attack plan. To model this scenario, we formulate a two-player, three-stage, perfect information, sequential move, zero-sum game that accounts for, respectively, a …

An Examination Of Economic Metrics As Indicators Of Air Force Retention, Helen L. Jantscher

Theses and Dissertations

Fluctuations in the economy can cause military recruitment and retention plans to go awry. By focusing on various economic metrics, it is possible to anticipate changes in retention rates for specific Air Force Specialty Codes (AFSCs). To address the challenge of maintaining a robust and mission capable Air Force, a correlation analysis is employed to determine the relationship between certain economic indicators and AFSC retention rates. As one might suspect, retention rates follow the trend of decreasing when the economy is strong. Of interest, we found two AFSCs which go against this trend. Namely, the retention rates for officers in …

Modeling The Components Of An Economy As A Complex Adaptive System, Richard J. Mickelsen

Theses and Dissertations

Complex systems science is a relatively new discipline and has not been widely applied to the field of economics. Much of current economic theory relies on principles of constrained optimization and often fails to see economic variables as part of an interconnected network. While tools for forecasting economic indicators are based primarily on autoregressive techniques, these techniques are not always well-suited to predicting the future performance of highly volatile data sets such as the stock market. This research portrays the stock market as one component of a networked system of economic variables, with the federal funds rate acting as an …

Modeling And Economy’S Dynamics And External Influences Through A System Of Differential Equations, Thomas M. Dickey

Theses and Dissertations

This research proposes a methodology to develop models for the greater understanding of the application of the economic instrument of national power through a selection of factors that define the economic condition of a country. The major components of an economy are identified as GDP per capita, a treasury bond yield, and a major stock market index. The components have interconnected dynamics along with external influences from the United Stated Federal Funds Rate and foreign direct investment. These connections are considered through a metamodel in the form of a system of differential equations which is solved as an inverse problem. …

A Logistic Regression And Markov Chain Model For The Prediction Of Nation-State Violent Conflicts And Transitions, Nicholas Shallcross

Theses and Dissertations

Using open source data, this research formulates and constructs a suite of statistical models that predict future transitions into and out of violent conflict and forecasts the regional and global incidences of violent conflict over a ten-year time horizon. A total of thirty predictor variables are tested and evaluated for inclusion in twelve conditional logistic regression models, which calculate the probability that a nation will transition from its current conflict state, either In Conflict or Not in Conflict, to a new state in the following year. These probabilities are then used to construct a series of nation-specific Markov chain models …

Application Of Non-Rated Line Officer Attrition Levels And Career Field Stability, Christine L. Zens

Theses and Dissertations

The Air Force monitors the strength of its active duty officer force and attempts to achieve the difficult challenge of employing a diversity of talent among career specialties and experience levels. This study completes two objectives, predicting future manning levels for 23 career fields, and providing a statistical framework to assess the stability of these fields. The first part of the study applies regression and survival analysis to subpopulations within the active duty Air Force officer corps, and then aggregates them by year to forecast future personnel levels. Four career fields are considered, including Acquisitions (ACQ), Logistics (LOG), Support (SPT), …

Evaluation Of Verification Approaches Applied To A Nonlinear Control System, Kerianne H. Gross

Theses and Dissertations

As the demand for increasingly complex and autonomous systems grows, designers may consider computational and artificial intelligence methods for more advanced, re- active control. While the performance gained by such increasingly intelligent systems may be superior to traditional control techniques, the lack of transparency in the systems and opportunity for emergent behavior limits their application in the field. New verification and validation methods must be developed to ensure the output of such controllers do not put the system or any people interacting with it in danger. This challenge was highlighted by the former Air Force Chief Scientist in his 2010 …

Civil Engineer Company Grade Officer Training Needs Analysis For Contingency Operations, Brian S. Greszler

Theses and Dissertations

In terms of active duty personnel, the USAF is the smallest it has ever been since its creation in 1947. With fewer personnel to accomplish essential tasks, the training of Airmen is more important than ever. Outdated and irrelevant training can lead to gaps in the knowledge of trainees. The purpose of this research was to analyze the training needs of Civil Engineer (CE) Company Grade Officers (CGOs) in the contingency environment. This was done by first conducting a Job Analysis (JA). The JA resulted in a list of 36 critical tasks and 58 important Knowledge, Skills, and Abilities (KSAs). …

Mission Dependency Index Of Air Force Built Infrastructure: Knowledge Discovery With Machine Learning, Clark W. Smith

Theses and Dissertations

Mission Dependency Index (MDI) is a metric developed to capture the relative criticality of infrastructure assets with respect to organizational missions. The USAF adapted the MDI metric from the United States Navy’s MDI methodology. Unlike the Navy’s MDI data collection process, the USAF adaptation of the MDI metric employs generic facility category codes (CATCODEs) to assign MDI values. This practice introduces uncertainty into the MDI assignment process with respect to specific missions and specific infrastructure assets. The uncertainty associated with USAF MDI values necessitated the MDI adjudication process. The MDI adjudication process provides a mechanism for installation civil engineer personnel …