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The Effect Of Using Palm Oil As An Electron Donor For The Reductive Dechlorination Of Trichloroethylene (Tce), Shivani Swamy Dec 2021

The Effect Of Using Palm Oil As An Electron Donor For The Reductive Dechlorination Of Trichloroethylene (Tce), Shivani Swamy

All Theses

TCE is currently remediated using physical methods like air stripping and granular activated carbon adsorption. While physical and chemical processes work on a site-specific basis, biological strategies have been favored as they are economical and reliable. The objective of this work was to determine the feasibility of using palm oil as an electron donor in the reductive dechlorination of TCE to ethene. Palm oil was considered for the study because it is locally grown in many parts of the world. The palm oil that does not meet the industry standards is discarded. Despite the environmental impacts caused by the palm …


Preferential Flow In Riparian Buffers: Current Research And Future Needs., Derek M. Heeren, Lucie Guertault, Kyle Mankin Dec 2021

Preferential Flow In Riparian Buffers: Current Research And Future Needs., Derek M. Heeren, Lucie Guertault, Kyle Mankin

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Preferential flow in riparian buffers can substantially compromise their effectiveness in reducing contaminants from overland runoff. The objective of this article is to introduce a collection of five articles on current research into subsurface preferential flow measurement, visualization, modeling, and impacts on contaminant fate and transport at scales ranging from the subsurface pore scale to the plot scale to the watershed scale. This collection presents selected works from a broader invited session on “Preferential flow and piping in riparian buffers” at the 2020 ASABE Annual International Meeting. Major findings include: new methodologies, such as light transmission and geophysics, to characterize …


Sprinkler Irrigation System Field Checklist, Charles C. Hillyer, R. Troy Peters, Xin Qiao, Derek M. Heeren, Jake Larue, Clarence Prestwich, Sandeep Bhatti Dec 2021

Sprinkler Irrigation System Field Checklist, Charles C. Hillyer, R. Troy Peters, Xin Qiao, Derek M. Heeren, Jake Larue, Clarence Prestwich, Sandeep Bhatti

Department of Agricultural and Biological Systems Engineering: Faculty Publications

This recommendation came out of a noted need by the ASABE NRES-241 sprinkler irrigation committee in 2019 committee meeting for a simple checklist to quickly educate new center pivot operators on what to look for to determine if a center pivot is operating at designed performance. This checklist is meant to be simple and user friendly. Simple and clear language was incorporated purposefully. It is intended as a quick guide to new irrigators, or as a reminder to more experienced irrigators as to what to check to ensure efficient and effective center pivot and linear move irrigation system operation for …


Corn Fiber As A Biomass Feedstock For Production Of Succinic Acid, Lisbeth Vallecilla-Yepez, Divya Ramchandran, Dianna Long, Rajib Saha, Mark R. Wilkins Dec 2021

Corn Fiber As A Biomass Feedstock For Production Of Succinic Acid, Lisbeth Vallecilla-Yepez, Divya Ramchandran, Dianna Long, Rajib Saha, Mark R. Wilkins

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The selection of an economical carbon source is a fundamental parameter to establish a successful industrial succinic acid (SA) bioprocess. In this work, corn fiber (CF), a renewable and an inexpensive source of carbohydrates, was successfully used for bioproduction of SA. Optimized liquid hot water (LHW) pretreatment followed by enzymatic hydrolysis were used to obtain corn fiber hydrolysate (CFH). Results in batch fermentation with Actinobacillus succinogenes showed that a control solution mimicking CFH produced 28.7 g/L of SA with a yield of 0.67 g SA/g sugars, while fermentation of CFH produced 27.8 g/L of SA with a yield of 0.61 …


Spatiotemporal Pattern Detection With Neuromorphic Circuits, Robert C. Ivans Dec 2021

Spatiotemporal Pattern Detection With Neuromorphic Circuits, Robert C. Ivans

Boise State University Theses and Dissertations

In this dissertation, neuromorphic circuits are used to implement spiking neural networks in order to detect spatiotemporal patterns. Unsupervised training and detection-by-design techniques were used to attain the appropriate connectomes and perform pattern detection.

Unsupervised training was performed by feeding random digital spikes with a repeating embedded spatiotemporal pattern to a spiking neural network composed of leaky integrate-and-fire neurons and memristor-R(t) element circuits which implement spike-timing-dependent plasticity learning rules.

Detection-by-design was achieved using neuromporphic circuits and digital logic gates. When detection-by-design was achieved using both neuromorphic circuits and digital logic gates, a network was created of spatiotemporal pattern detector circuits, …


Nuclear Envelope Mechanobiology: Linking The Nuclear Structure And Function, Matthew Goelzer, Julianna Goelzer, Matthew L. Ferguson, Corey P. Neu, Gunes Uzer Dec 2021

Nuclear Envelope Mechanobiology: Linking The Nuclear Structure And Function, Matthew Goelzer, Julianna Goelzer, Matthew L. Ferguson, Corey P. Neu, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate. In mesenchymal stem cells of musculoskeletal tissues, changes in nuclear structures are emerging as a key modulator of their differentiation and proliferation programs. In this review we will first introduce the structural elements of the nucleoskeleton and discuss the current literature on how nuclear structure and signaling are altered in relation to environmental and tissue level mechanical cues. We will focus on state-of-the-art techniques to …


2021 Summer-Fall Graduate Recognition Program, Propulsion Research Center, Robert Frederick Dec 2021

2021 Summer-Fall Graduate Recognition Program, Propulsion Research Center, Robert Frederick

PRC Graduate Recognition

This program includes the graduate recognition program for summer and fall 2021. Includes photographs, upcoming events, recent publications, and student profiles.


A Machine Learning-Based Approach To Predict And Optimize The Performance Of Zero Energy Building (Zeb): A Case Study For Florida, Benjamin Kubwimana Dec 2021

A Machine Learning-Based Approach To Predict And Optimize The Performance Of Zero Energy Building (Zeb): A Case Study For Florida, Benjamin Kubwimana

Theses and Dissertations

Machine learning is currently one of the most searched fields aiming to solve real-life problems. Building simulation software tools help engineers estimate building energy behaviors before the actual construction, allowing implementation of more energy efficient choices in building design and construction. Current building energy simulation software tools are mostly physics-based and still lack the benefit obtained with machine learningbased modeling, which offers fast and less computationally expensive techniques to build energy models and efficiently perform design optimization. This thesis presents a machine learning-based approach for building energy modeling and optimizing design parameters to minimize building’s energy consumption. The study is …


Towards Understanding Protein Immobilization Rules Through Site-Specific Covalent Immobilization Of T4 Lysozyme, Maxwell Hilbert Dec 2021

Towards Understanding Protein Immobilization Rules Through Site-Specific Covalent Immobilization Of T4 Lysozyme, Maxwell Hilbert

All Dissertations

Soluble enzymes have the unique ability to assist the conversion of complex substrates in fewer steps compared to conventional chemical synthesis; however, when immobilized to a surface, the insoluble enzyme's activity and stability can suffer in its new environment. To improve upon future immobilized enzyme efficacy, a fundamental understanding of the interactions across the enzyme, linker, and surface during covalent, site-specific immobilization that can be detrimental to its activity is required. More specifically, using a well-characterized and model enzyme, T4 lysozyme (T4L), 28 different cysteine attachment points' effects on site-specifically immobilized activity are examined. Different combinations of heterobifunctional amine-to-sulfhydryl crosslinkers …


Time-Lapse Observation Of Sarcomeric Addition In Hypertrophic Models Based On A Tissue Like Cardiomyocyte Culture, Ailin Wei Dec 2021

Time-Lapse Observation Of Sarcomeric Addition In Hypertrophic Models Based On A Tissue Like Cardiomyocyte Culture, Ailin Wei

All Dissertations

Cardiac hypertrophy is the response of the heart to increased mechanical stress exerted on the heart. In a hypertrophic heart, the muscles elongate or/and thicken with cardiomyocytes growing sizes. It is assumed that cardiomyocytes elongate by adding sarcomeres in series; the cardiomyocytes thicken with the addition of sarcomeres in the parallel position.

In this study, a tissue-like culture model was achieved with step-like ICDs. Uniaxial static stretch has been applied to our unique culture model for studying mechanical-load-induced cardiac hypertrophy. Hypertrophic responses of these cardiomyocytes have been confirmed on transcriptional and translational levels in our tissue-like model. The two-photon excitation …


Resiliency Of Utah's Road Network: A Logit-Based Approach, Max Evan Barnes Dec 2021

Resiliency Of Utah's Road Network: A Logit-Based Approach, Max Evan Barnes

Theses and Dissertations

The Utah Department of Transportation (UDOT) manages and maintains a complex state-wide network of highways. Recent incidents such as the collapse of the I-35W bridge in Min- neapolis, Minnesota, and the I-85/Piedmont Road fire and subsequent bridge collapse in Atlanta, Georgia, have brought identification of transportation network vulnerabilities to the forefront of UDOT’s planning efforts. Traditional estimates of transportation network impacts have focused on increases to user travel time or the volume of affected traffic, but studies of these disasters have revealed that when facing a degraded transportation network, people adjust their trip making in terms of destination, mode, and …


Classifying Electrocardiogram With Machine Learning Techniques, Hillal Jarrar Dec 2021

Classifying Electrocardiogram With Machine Learning Techniques, Hillal Jarrar

Master's Theses

Classifying the electrocardiogram is of clinical importance because classification can be used to diagnose patients with cardiac arrhythmias. Many industries utilize machine learning techniques that consist of feature extraction methods followed by Naive- Bayesian classification in order to detect faults within machinery. Machine learning techniques that analyze vibrational machine data in a mechanical application may be used to analyze electrical data in a physiological application. Three of the most common feature extraction methods used to prepare machine vibration data for Naive-Bayesian classification are the Fourier transform, the Hilbert transform, and the Wavelet Packet transform. Each machine learning technique consists of …


Integration Of Internet Of Things And Health Recommender Systems, Moonkyung Yang Dec 2021

Integration Of Internet Of Things And Health Recommender Systems, Moonkyung Yang

Electronic Theses, Projects, and Dissertations

The Internet of Things (IoT) has become a part of our lives and has provided many enhancements to day-to-day living. In this project, IoT in healthcare is reviewed. IoT-based healthcare is utilized in remote health monitoring, observing chronic diseases, individual fitness programs, helping the elderly, and many other healthcare fields. There are three main architectures of smart IoT healthcare: Three-Layer Architecture, Service-Oriented Based Architecture (SoA), and The Middleware-Based IoT Architecture. Depending on the required services, different IoT architecture are being used. In addition, IoT healthcare services, IoT healthcare service enablers, IoT healthcare applications, and IoT healthcare services focusing on Smartwatch …


English-To-Ipa Transcription, Riley Roberts Dec 2021

English-To-Ipa Transcription, Riley Roberts

Undergraduate Honors Capstone Projects

The purpose of this project was to create a tool that could automate English-to-IPA (International Phonetic Alphabet) transcription. Research was done to determine what would be required to perform such a transcription. After researching and experimenting with existing tools, it was determined that developing the signal processing and Artificial Intelligence model portion of the application would be too intensive to successfully complete within the timeframe of this project.

The choice was made to develop an iOS application, with the Python library Allosaurus used to do the speech processing and as the Artificial Intelligence model. This model was then deployed in …


Evaluation Of Varying Graphene Oxides Through Their Physicochemical Characterizations On Erythrocytes, Hs27 Cells, Escherichia Coli And Staphylococcus Aureus Bacteria Cell Lines, To Assess Graphene Oxides Cytotoxicity., Miriam Montana Dec 2021

Evaluation Of Varying Graphene Oxides Through Their Physicochemical Characterizations On Erythrocytes, Hs27 Cells, Escherichia Coli And Staphylococcus Aureus Bacteria Cell Lines, To Assess Graphene Oxides Cytotoxicity., Miriam Montana

Open Access Theses & Dissertations

Research on the toxicity of Graphene Oxides (GO) has captivated interest in the field of material science, environmental sciences, and medicine for their avail significance in biomedical engineer applications either as integrates, enhancements, or in the making of medical devices. Moreover, there is still a lack of understanding as to what characteristics on GOs causes them to be cytotoxic at a cellular level. In our study we synthesized four different GOs by varying in both the method used for oxidation (Modified Hummer’s method & Improved Marcano-Tour’s method), and the precursor parent graphite, for a standardization approach to aid in the …


Building Energy Model Simulation Of A Single Building In Comparison To A Broader Building Stock, Paola Michelle Santillano Dec 2021

Building Energy Model Simulation Of A Single Building In Comparison To A Broader Building Stock, Paola Michelle Santillano

Open Access Theses & Dissertations

Residential facilities and buildings are the largest consumers of energy in the United States. More than 76% of electricity and more than 40% of all energy consumption comes from providing a comfortable and healthy environment in buildings. Prioritizing building energy technology goals for performance and cost can significantly reduce energy use within the next ten years despite a substantial forecasted population increase. Retrofitting existing buildings and improving future construction has the potential to realize cost savings and environmental benefits over time. A key component to realizing these benefits is regional building energy modeling. One of the challenges to widespread building …


A Integrated Approach Of Deep Learning And Augmented Reality For Pneumonia Detection In Chest X-Ray Images, Jeevarathinam Senthilkumar Dec 2021

A Integrated Approach Of Deep Learning And Augmented Reality For Pneumonia Detection In Chest X-Ray Images, Jeevarathinam Senthilkumar

Open Access Theses & Dissertations

Pneumonia is a viral or fungal illness that spreads to the lungs of the human body, causing fluid to accumulate in the lungs' air sacs. Millions of people are affected by this disease each year. One of the most common radiological diagnostics for diagnosing and screening this kind of sickness is a chest X-ray. The most commonly available radiological test for diagnosing and screening this kind of illness is a chest X-ray. An inaccurate diagnosis, especially over-diagnosis and under-diagnosis, is a common issue in the medical sector. As another issue, human-assisted diagnosis has limitations like the availability of an expert, …


Development Of Metaheuristic Algorithms For The Efficient Allocation Of Power Flow Control Devices, Eduardo Jose Castillo Fatule Dec 2021

Development Of Metaheuristic Algorithms For The Efficient Allocation Of Power Flow Control Devices, Eduardo Jose Castillo Fatule

Open Access Theses & Dissertations

Modern energy grids have become extremely complex systems, requiring more variable and active flow control. As a remedy to this, Distributed Flexible AC Transmission Systems (D-FACTS) are cost-efficient devices used to mitigate power flow congestion and integrate renewable energies. The objective of this research is then to propose an efficient multiple objective evolutionary algorithm to solve a stochastic model for D-FACTS allocation, which aims to optimize various objectives related to cost, grid health, and environmental impacts. The model was implemented on a modified RTS-96 test system, and the results show that optimally allocating D-FACTS modules using the proposed model can …


Cell Bioprinting: A Novel Approach For Alpha Cell To Beta Cell Transdifferentiation, Atzimba Casas Dec 2021

Cell Bioprinting: A Novel Approach For Alpha Cell To Beta Cell Transdifferentiation, Atzimba Casas

Open Access Theses & Dissertations

Diabetes is a chronic disease that occurs in the body when the pancreas fails to either produce insulin (TID) or does not effectively use the insulin produced (TIID) and poses further health complications as well as an insurmountable economic impact.[1] Type I diabetes is an autoimmune disease characterized by a deficient amount of insulin production on account of the body’s immune system destroying its own β-cells.[2] Current diabetes treatment methods include the administration of insulin via injections or islet transplantation therapy. However, although both are viable options, they come with limitations that make the managing of this disease difficult. It …


Goes-16 Level 2 Land Surface Temperature Product-Filling For Cloud Masked Data, Guadalupe Ortega Dec 2021

Goes-16 Level 2 Land Surface Temperature Product-Filling For Cloud Masked Data, Guadalupe Ortega

Open Access Theses & Dissertations

The GOES-16 satellite ground segment team develops different levels of environmental products and makes them readily available to the public. The level 2 Land Surface Temperature (LST) product aims to provide a remote measurement of the Earth’s surface temperature every hour. LST is of fundamental importance to many aspects of the geosciences, for example, to study the Urban Heat Islands (UHI) effect. The product however, does not provide values for pixels where the satellite imager’s view is obstructed by clouds, as determined by a cloud mask intermediate product. The objective of this thesis is to estimate LST in the cloud …


Estimation Of High-Resolution Evapotranspiration In Heterogeneous Environments Using Drone-Based Remote Sensing, Ayman M. M. Nassar Dec 2021

Estimation Of High-Resolution Evapotranspiration In Heterogeneous Environments Using Drone-Based Remote Sensing, Ayman M. M. Nassar

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Evapotranspiration (ET) is a key element of hydrological cycle analysis, irrigation demand, and for better allocation of water resources in the ecosystem. For successful water resources management activities, precise estimate of ET is necessary. Although several attempts have been made to achieve that, variation in temporal and spatial scales constitutes a major challenge, particularly in heterogeneous canopy environments such as vineyards, orchards, and natural areas. The advent of remote sensing information from different platforms, particularly the small unmanned aerial systems (sUAS) technology with lightweight sensors allows users to capture high-resolution data faster than traditional methods, described …


Ammonia Emission Assessment From Gasoline And Diesel Engines Under Utah Specific Conditions, Motasem Suleiman Abualqumboz Dec 2021

Ammonia Emission Assessment From Gasoline And Diesel Engines Under Utah Specific Conditions, Motasem Suleiman Abualqumboz

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study aims to quantify ammonia (NH3) emission rates from the on-road gasoline and diesel motor vehicles fleet of the Wasatch Front, Utah. For this purpose, a portable Pollution Emissions Monitoring System (PEMS) was used to estimate NH3 emission rates from a representative fleet of 53 in-use light-duty (LD) gasoline and diesel vehicles over a total of 166 on-road Real Driving Emissions (RDE) tests. The post-catalyst concentrations of NH3 precursors, nitrogen oxides (NOx) and carbon monoxide (CO) were also measured. The outcomes of this study showed that a motor vehicle in the Wasatch Front …


Hobby Grade Lithium-Ion Batteries For Spacecraft Applications: Establishing An Automated Electrical Characteristics Testing Procedure For Flight Acceptance Of Non-Space-Grade Small Secondary Batteries, Braidon Hughes Dec 2021

Hobby Grade Lithium-Ion Batteries For Spacecraft Applications: Establishing An Automated Electrical Characteristics Testing Procedure For Flight Acceptance Of Non-Space-Grade Small Secondary Batteries, Braidon Hughes

Graduate Theses and Dissertations

Li-ion batteries are widely used due to the large amount of rechargeable energy they pack into a small, light package. This higher energy density makes Li-ion batteries ideal for small satellite applications, specifically CubeSats. CubeSats have grown in popularity in higher level education due to the National Aeronautics and Space Administration’s implementation of the Cube Satellite Launch Initiative, making it easier and cheaper to conduct small, low orbit missions. Because these CubeSats are occupying the same space as a crewed spacecraft, it is imperative that they are safe. There are numerous reports of Li-ion batteries creating fires that result in …


Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso Dec 2021

Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso

Graduate Theses and Dissertations

Immune checkpoint drugs have completely changed the way people treat metastatic melanoma and non-small-cell lung cancer. While the impacts of these immunological checkpoints and their suppression on T cell function are well characterized, their consequences on the tumor microenvironment are not. In a CT26 mouse colorectal cancer model, we employed diffuse reflectance spectroscopy to track in vivo tumor microenvironmental alterations in response to immune checkpoint inhibitors. On three separate days, animals bearing CT26 tumor xenografts were given anti-PD-L1, anti-CTLA-4, a combination of both inhibitors, and isotype control. Within the first 6 days, monotherapy with either anti-PD-L1 or anti-CTLA-4 resulted in …


Incorporation Of Zinc In Pre-Alloyed Cuin[Zn]S2/Zns Quantum Dots, Jean Carlos Morales Orocu Dec 2021

Incorporation Of Zinc In Pre-Alloyed Cuin[Zn]S2/Zns Quantum Dots, Jean Carlos Morales Orocu

Graduate Theses and Dissertations

Since the early 2000s heavy-metal-free quantum dots (QDs) such as CuInS2/ZnS have attempted to replace CdSe, their heavy-metal-containing counterparts. CuInS2/ZnS is synthesized in a two-step process that involves the fabrication of CuInS2 (CIS) nanocrystals (NCs) followed by the addition of zinc precursors. Instead of the usual core/shell architecture often exhibited by binary QDs, coating CIS QDs results in alloyed and/or partially alloyed cation-exchange (CATEX) QDs. The effect that zinc has on the properties of CIS NCs was studied by incorporating zinc during the first step of the synthesis. Different In:Cu:Zn ratios were employed in this study, maintaining a constant 4:1 …


Investigation Of Iron-Nickel Films Based Catalysts: Controlling Hydrogen Evolution Reaction (Her) Through An Electrode-Electrolyte Engineering Approach, Sergio Ivan Perez Bakovic Dec 2021

Investigation Of Iron-Nickel Films Based Catalysts: Controlling Hydrogen Evolution Reaction (Her) Through An Electrode-Electrolyte Engineering Approach, Sergio Ivan Perez Bakovic

Graduate Theses and Dissertations

Electrochemical energy conversion technologies need to be economically viable in order to be adopted. Earth-abundant transition metals (i.e., Fe, Co, and Ni) have attracted attention due to their high availability, low cost, and catalytic characteristics that are in many cases found in and exploited by nature. Herein, we synthesize FexNi100-xOy electrocatalyst films and study how the electrocatalyst-electrolyte interactions alter the hydrogen evolution reaction (HER).In this work, FexNi100-xOy films were synthesized to study the composition, chemical state, and morphology. Characterization results provided a well-established electrocatalyst film platform to then proceed with electrochemical evaluations. The effects of the electrode composition and electrochemically …


Machine Learning For Unmanned Aerial System (Uas) Networking, Jian Wang Dec 2021

Machine Learning For Unmanned Aerial System (Uas) Networking, Jian Wang

Doctoral Dissertations and Master's Theses

Fueled by the advancement of 5G new radio (5G NR), rapid development has occurred in many fields. Compared with the conventional approaches, beamforming and network slicing enable 5G NR to have ten times decrease in latency, connection density, and experienced throughput than 4G long term evolution (4G LTE). These advantages pave the way for the evolution of Cyber-physical Systems (CPS) on a large scale. The reduction of consumption, the advancement of control engineering, and the simplification of Unmanned Aircraft System (UAS) enable the UAS networking deployment on a large scale to become feasible. The UAS networking can finish multiple complex …


Modeling Watershed Sensitivity To Climate Change In Systems Affected By Discharge Of Mine Tailings, Johnette C. Shockley Dec 2021

Modeling Watershed Sensitivity To Climate Change In Systems Affected By Discharge Of Mine Tailings, Johnette C. Shockley

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

For more than a century, a large volume of gold-mining tailings was deposited in Whitewood Creek and the Belle Fourche River, tributaries to the Cheyenne River in western South Dakota. Much of it still remains, and field and historical evidence indicates continued remobilization of tailings-containing alluvium in these bedrock-dominated channels. Both long-term, natural fluctuations in climate and anthropogenically driven changes can impact regional precipitation, temperature, hydrologic patterns, and ecosystem functions. Such changes have the potential to affect both the transport and distribution of arsenic-laden sediments and mechanical erosion that can undermine the stability of channel-bed and overbank material.

This study …


Influencing The Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, And Fluid Management In A Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino Dec 2021

Influencing The Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, And Fluid Management In A Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino

All Dissertations

The total population of diagnosed and undiagnosed diabetes mellitus in the United states is expected to rise by 54% between the years of 2015 and 2030 contributing to $200 billion in health care expense. The exponential rise in common diabetic wounds, such as diabetic foot ulcers, puts a large population at risk for complications such as infection, amputation, and even death. Peripheral neuropathy leading to late diagnoses, patient non-compliance, and lack of holistic treatment options all contribute to complications with the incidence of new ulcer formation after treatment reaching 50%. This work explores the design, development, and in vitro evaluation …


Development Of Solution Blow Spun Nanofibers As Electrical And Whole Cell Biosensing Interfaces, Craig Levar Miller Dec 2021

Development Of Solution Blow Spun Nanofibers As Electrical And Whole Cell Biosensing Interfaces, Craig Levar Miller

All Dissertations

Infectious pathogens place a huge burden on the US economy with more than $120 billion spent annually for direct and indirect costs for the treatment of infectious diseases. Rapid detection schemes continue to evolve in order to meet the demand of early diagnosis. In chronic wound infections, bacterial load is capable of impeding the healing process. Additionally, bacterial virulence production works coherently with bacterial load to produce toxins and molecules that prolongs the healing cycle. This work examines the use of nonwoven polymeric conductive and non-conductive nanofiber mats as synthetic biosensor scaffolds, drug delivery and biosensor interface constructs. A custom-made …