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Development Of A Scalable Edge-Cloud Computing Based Variable Rate Irrigation Scheduling Framework, Eric J. Wilkening, Derek M. Heeren, Yeyin Shi, Abia Katimbo, Precious N. Amori, Guillermo R. Balboa, Laila A. Puntel, Kuan Zhang, Daran R. Rudnick Jul 2023

Development Of A Scalable Edge-Cloud Computing Based Variable Rate Irrigation Scheduling Framework, Eric J. Wilkening, Derek M. Heeren, Yeyin Shi, Abia Katimbo, Precious N. Amori, Guillermo R. Balboa, Laila A. Puntel, Kuan Zhang, Daran R. Rudnick

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Currently, variable-rate precision irrigation (VRI) scheduling methods require large amounts of data and processing time to accurately determine crop water demands and spatially process those demands into an irrigation prescription. Unfortunately, irrigated crops continue to develop additional water stress when the previously collected data is being processed. Machine learning is a helpful tool, but handling and transmitting large datasets can be problematic; more rural areas may not have access to necessary wireless data transmission infrastructure to support cloud interaction. The introduction of “edge-cloud” processing to agricultural applications has shown to be effective at increasing data processing speed and reducing the …


Construction Of A Real-Time Forecast Model With Deep Learning Techniques For Coastal Engineering & Processes: Nested In Basin Scale Suite Of Models, Md Ahsan Habib Jul 2023

Construction Of A Real-Time Forecast Model With Deep Learning Techniques For Coastal Engineering & Processes: Nested In Basin Scale Suite Of Models, Md Ahsan Habib

Theses and Dissertations

The study aims to develop a robust and adaptable real-time forecasting system for coastal and estuarine regions, considering the challenges of limited or unavailable forecast data. To address the challenge of data unavailability, this study proposes the application of a deep learning model (DLM). This research involves the development of a high-resolution numerical model nested within global models. Calibration and validation are performed by comparing the model with observed data. The study explores the effects of various parameters, such as vertical resolution, wind variability, and bottom roughness, on model performance. It finds that the 10-layer model improves vertical stratification and …


Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi Jul 2023

Characterization And Estimation Of Musculoskeletal Pain Using Machine Learning, Boluwatife Faremi

Master's Theses

Traditional scales utilized for recording pain are known to be highly subjective and biased due to inaccuracies in recollecting actual pain intensities. As a result, machine learning (ML) models that are trained using these scores as ground truth are reported to have low performance for objective pain classification because of the huge disparity between what was felt in moments of pain and the scores recorded afterward.

In the present study, two devices were designed for gathering real-time, continuous in-session subjective pain scores and the recording of the autonomic nervous system (ANS) altered endodermal (EDA) activity. 24 participants were recruited to …


Predicting Material Structures And Properties Using Deep Learning And Machine Learning Algorithms, Yuqi Song Jul 2023

Predicting Material Structures And Properties Using Deep Learning And Machine Learning Algorithms, Yuqi Song

Theses and Dissertations

Discovering new materials and understanding their crystal structures and chemical properties are critical tasks in the material sciences. Although computational methodologies such as Density Functional Theory (DFT), provide a convenient means for calculating certain properties of materials or predicting crystal structures when combined with search algorithms, DFT is computationally too demanding for structure prediction and property calculation for most material families, especially for those materials with a large number of atoms. This dissertation aims to address this limitation by developing novel deep learning and machine learning algorithms for effective prediction of material crystal structures and properties. Our data-driven machine learning …


Extending The Convolution In Graph Neural Networks To Solve Materials Science And Node Classification Problems, Steph-Yves Mike Louis Jul 2023

Extending The Convolution In Graph Neural Networks To Solve Materials Science And Node Classification Problems, Steph-Yves Mike Louis

Theses and Dissertations

The usage of graph to represent one's data in machine learning has grown in popularity in both academia and the industry due to its inherent benefits. With its flexible nature and immediate translation to real life observed objects, graph representation had a considerable contribution in advancing the state-of-the-art performance of machine learning in materials.

In this dissertation proposal, we discuss how machines can learn from graph encoded data and provide excellent results through graph neural networks (GNN). Notably, we focus our adaptation of graph neural networks on three tasks: predicting crystal materials properties, nullifying the negative impact of inferior graph …


Streamwise And Vertical Dispersal Of Tracer Stones From A Continuously Supplied Source, Amanda Grace Balkus Jul 2023

Streamwise And Vertical Dispersal Of Tracer Stones From A Continuously Supplied Source, Amanda Grace Balkus

Theses and Dissertations

Individual movement of sediment grains is oftentimes studied with the use of tracer stones. Studies performed both in the field, in the laboratory and with numerical models involve installing a patch of stones (tracers) on the bed surface and rarely deep in the deposit. Once installed, particle displacement is monitored over time scales varying from one flood to several years. These studies are useful, for example, to study bedload transport dynamics, understand contaminant fate and transport as well as to identify and define stream restoration practices (e.g. quality of fish habitat). Here we use a vertically continuous model to study …


Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle Jul 2023

Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle

Theses and Dissertations

In its 2022 commercial market outlook, Boeing forecasted an 80% increase in the global fleet through 2041 compared to 2019 pre-pandemic levels. This sharp rise in demand will drive pressure onto airframe manufacturers to ramp up production and find more efficient ways to design and manufacture airplanes. Complicating this challenge is the industry’s recent transformation from traditional metal-based airframes towards hybrid composite-metal aircraft. While composites have been used in aviation for decades, aircraft manufacturers are still struggling to design and manufacture quality parts at a high rate. Automated Fiber Placement (AFP) is one of the main manufacturing techniques used to …


Development Of Atomistic Machine Learning Approaches For Thermal Properties Of Multi-Component Solids And Liquids, Alejandro David Rodriguez Jul 2023

Development Of Atomistic Machine Learning Approaches For Thermal Properties Of Multi-Component Solids And Liquids, Alejandro David Rodriguez

Theses and Dissertations

Currently, heat transfer in many industries is the limiting factor for innovation, especially in the energy sector. For example, maximizing thermal conductivity of ceramic coatings in power plant devices improves the overall electrical to thermal energy ratio, whereas minimizing thermal conductivity is required for desirable heat-to-electricity conversion in thermoelectric devices. As such, rapid discovery of new materials with extreme thermal conductivity values is quintessential for the near-future deployment of current and developing energy applications.

The vibrational properties of crystalline materials are essential for their ability to conduct heat. Fundamentally, the restorative atomic forces of displaced atoms are sufficient to represent …


Data-Driven Porosity Prediction For Directed Energy Deposition, Georgia E. Kaufman Jul 2023

Data-Driven Porosity Prediction For Directed Energy Deposition, Georgia E. Kaufman

Electrical and Computer Engineering ETDs

Stochastic flaw formation leading to poor print quality is a major obstacle to the utility of directed energy deposition (DED), a laser and metal powder-based additive manufacturing technology for construction and repair of custom metal parts. While melt pool temperature variability is known to be a major factor in flaw formation, control schemes to decrease flaw formation are limited by a lack of physics-based models that fully and accurately describe DED. In this work, a stochastic reachability analysis with a data-driven model based on thermal images of the melt pool was conducted to determine the likelihood of violating melt pool …


Mitochondrial Transfer From Cancer-Associated Fibroblasts Increases Migration In Aggressive Breast Cancer, Kevin F. Gwolas, Sarah Libring, Emily Berestesky, Shayan Gholizadeh, Samantha C. Schwager, Andra R. Frost, Thomas R. Gaborski, Jian Zhang, Cynthia A. Reinhart-King Jul 2023

Mitochondrial Transfer From Cancer-Associated Fibroblasts Increases Migration In Aggressive Breast Cancer, Kevin F. Gwolas, Sarah Libring, Emily Berestesky, Shayan Gholizadeh, Samantha C. Schwager, Andra R. Frost, Thomas R. Gaborski, Jian Zhang, Cynthia A. Reinhart-King

Biomedical Engineering Faculty Publications and Presentations

Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration. CAFs are known to increase invasion of less-aggressive breast cancer cells through matrix remodeling and leader–follower dynamics. Here, we demonstrate that CAFs communicate with breast cancer cells through the formation of contact-dependent tunneling nanotubes (TNTs), which allow for the exchange of cargo between cell types. CAF mitochondria are an integral cargo component and are sufficient to increase the 3D migration of cancer cells. This cargo transfer results in an increase in mitochondrial ATP production in cancer cells, whereas it …


A Direct Fiber Approach To Model Sclera Collagen Architecture And Biomechanics, Fengting Ji, Manik Bansal, Bingrui Wang, Yi Hua, Mohammad R. Islam, Felix Matuschke, Markus Axer, Ian A. Sigal Jul 2023

A Direct Fiber Approach To Model Sclera Collagen Architecture And Biomechanics, Fengting Ji, Manik Bansal, Bingrui Wang, Yi Hua, Mohammad R. Islam, Felix Matuschke, Markus Axer, Ian A. Sigal

Mechanical Engineering Faculty Publications

Sclera collagen fiber microstructure and mechanical behavior are central to eye physiology and pathology. They are also complex, and are therefore often studied using modeling. Most models of sclera, however, have been built within a conventional continuum framework. In this framework, collagen fibers are incorporated as statistical distributions of fiber characteristics such as the orientation of a family of fibers. The conventional continuum approach, while proven successful for describing the macroscale behavior of the sclera, does not account for the sclera fibers are long, interwoven and interact with one another. Hence, by not considering these potentially crucial characteristics, …


Using Machine Learning And Distributed Hydrologic Modeling To Predict Soil Texture, Surface Soil Moisture And Evapotranspiration In Jornada Experimental Range, Southwestern U.S., Jorge Andres Mayo Jul 2023

Using Machine Learning And Distributed Hydrologic Modeling To Predict Soil Texture, Surface Soil Moisture And Evapotranspiration In Jornada Experimental Range, Southwestern U.S., Jorge Andres Mayo

Open Access Theses & Dissertations

In water-limited ecosystems, detailed knowledge of the soil, vegetation, and atmosphere interactions is critical to understand the processes that control the partitioning of energy, water fluxes, and biogeochemical cycles within the critical zone. This Master's thesis is divided into two main contributing sections. The first, is on the use of machine learning to reconstruct missing soil type information, and the second, on the calibration and validation of a physically-based distributed hydrological model to estimate soil moisture and evapotranspiration within the Jornada Experimental Range of the U.S. in southern New Mexico. For the first contribution, three explainable, shallow machine-learning techniques are …


Analysis Of Evolution And Morphology Of Urban And Road Networks: Case Study Lebanon-Nabatiyeh Area, Amal Al Ghorayeb, Adel Elkordi, Ghaleb Faour, Zeinab Jaber, Youssef Attallah Jun 2023

Analysis Of Evolution And Morphology Of Urban And Road Networks: Case Study Lebanon-Nabatiyeh Area, Amal Al Ghorayeb, Adel Elkordi, Ghaleb Faour, Zeinab Jaber, Youssef Attallah

BAU Journal - Science and Technology

This study examines the morphology and evolution of urban and road networks and their relationship with topography in the Lebanon-Nabatiyeh area, by using GIS and remote sensing data. and calculate the annual urban growth percentage rate. The results reveal a clear relationship between the morphology of urban and road networks and their evolution over four periods, as well as the influence of the surrounding topography on their configuration. The study recommends that urban areas should be developed in areas with a slope range of 15º or more to improve the urban structure and infrastructure surrounding them. Understanding the evolution and …


Neurocomputing And Interfacing Digital Tasting System: Research, Design, And Evaluation, Amira J. Zaylaa, Ahmad El Hajj Jun 2023

Neurocomputing And Interfacing Digital Tasting System: Research, Design, And Evaluation, Amira J. Zaylaa, Ahmad El Hajj

BAU Journal - Science and Technology

The continuous evolution in computing and interfacing has been extended to develop multi-sensory experiences in many domains such as neurological, auditory, vision, and haptic domains. So far, only a few remarkable system approaches have been approved to be serving the taste sensation digitally. Although taste sensation is linked to the brain, there is a lack of optimal neurocomputing digital taste sensation systems. Our study provides a new neurocomputing method to digitally stimulate the sense of taste by electrical stimulation on the human tongue. We aim to link chemical stimulation and electrical stimulation in order to design an electronic interface for …


Methods And Surface Materials Repair For Concrete Structures – A Review, Lelian W. Elkhatib, Adel Elkordi, Jamal Khatib Jun 2023

Methods And Surface Materials Repair For Concrete Structures – A Review, Lelian W. Elkhatib, Adel Elkordi, Jamal Khatib

BAU Journal - Science and Technology

Concrete is a very critical material that may require maintenance and possible repair periodically, especially in important structure such as bridges. In general, concrete in structures (e.g. reinforced concrete) may be subjected to cracks due to a variety of reasons. These include, design and external environments such as the ingress of harmful ions into the concrete, unexpected extra loads including earthquakes. These cracks can affect not only the appearance of the structure but more importantly the structural performance of concrete and the integrity of the concrete structure. Therefore, when cracks occur a proper repair method should be selected, based on …


Localized Surface Plasmon Resonance Of Palladium Parallelepiped Nanoparticles, Salem Marhaba, Nourhan El Kawni Jun 2023

Localized Surface Plasmon Resonance Of Palladium Parallelepiped Nanoparticles, Salem Marhaba, Nourhan El Kawni

BAU Journal - Science and Technology

Localized surface plasmon resonance (LSPR) of palladium parallelepiped nanoparticle have been investigated using Finite Element Method (FEM) in the frame of COMSOL Multiphysics Software. Spectral characteristics (magnitude, peak position and width) of LSPR of a single Pd nanoparticle having the shape of a parallelepiped are investigated in two different cases. The first case studied the size effect on LSPR by fixing the height with varying both length and width. However, the second case studied the shape effect on the LSPR by rounding the corners of the parallelepiped for different radii while fixing its dimensions. The extinction cross-section spectra of these …


Three-Dimensional Higher-Order Compressive Sensing For Raypath Separation In An Acoustic Waveguide, Fengyan Zhong Jun 2023

Three-Dimensional Higher-Order Compressive Sensing For Raypath Separation In An Acoustic Waveguide, Fengyan Zhong

Journal of Marine Science and Technology–Taiwan

In an acoustic waveguide, the separation of multiple raypaths, especially close raypaths, is a challenging task in the presence of colored noise due to interference in the acoustic eld. In this paper, a three-dimensional higher-order compressive sensing method for raypath separation is proposed. The method is applied on an array-to-array experimental conguration where both emitter and reception arrays are used. With the array-to-array conguration, the raypaths are characterized by three parameters including arrival direction, departure direction, and arrival time. Furthermore, the performance of the proposed algorithm is illustrated by simulations and experiments. The numerical results based on simulation illustrate that …


Projection Of Sea Surface Temperature Based On Empirical Mode Decomposition And Its Application In Typhoon Number Forecast, Wen-Cheng Huang, Jung-Chen Lee Jun 2023

Projection Of Sea Surface Temperature Based On Empirical Mode Decomposition And Its Application In Typhoon Number Forecast, Wen-Cheng Huang, Jung-Chen Lee

Journal of Marine Science and Technology–Taiwan

The primary objective of this paper is to demonstrate the applicability of empirical mode decomposition (EMD) in projecting non-stationary daily sea surface temperature (SST) series, and the other is to apply the projected series of SST to estimate the number of typhoons. The study focuses on an area ranging from 5°N~25°N and 110°E~170°E, collecting daily sea temperature data and typhoons records within this region. The findings conclusively indicate that the EMD-based data generation method proposed in this paper can effectively addresses the limitations of previous hydrological models in generating non-stationary series, signifying a significant advancement in hydrological time series modeling …


Construction And Preliminary Application Of The Carbon-Based Spatial Governance Performance Evaluation System ——Taking Zhejiang Province As An Example, Lin Qu, Ganlin Xia, Cunkuan Bao Prof. Jun 2023

Construction And Preliminary Application Of The Carbon-Based Spatial Governance Performance Evaluation System ——Taking Zhejiang Province As An Example, Lin Qu, Ganlin Xia, Cunkuan Bao Prof.

CSID Journal of Infrastructure Development

Carbon is generated through human socio-economic activities, with territorial space serving as the medium for these activities. Variations in spatial governance result in differences in the scale, intensity and efficiency of social and economic activities, as well as energy and resource consumption and carbon emissions across diverse functional spaces. Consequently, spatial governance performance should be evaluated using carbon-related indicators. This study initially established a theoretical model for assessing spatial governance performance based on carbon and an evaluation method encompassing three dimensions or indices "level-progress-gap". Zhejiang Province and its 11 prefecture-level cities were selected as the research area for preliminary application …


Adaptive Plasmonic Metasurfaces For Radiative Cooling And Passive Thermoregulation, Azadeh Didari-Bader, Nooshin M. Estakhri, Nasim Mohammadi Estrakhri Jun 2023

Adaptive Plasmonic Metasurfaces For Radiative Cooling And Passive Thermoregulation, Azadeh Didari-Bader, Nooshin M. Estakhri, Nasim Mohammadi Estrakhri

Engineering Faculty Articles and Research

In this work, we investigate a class of planar photonic structures operating as passive thermoregulators. The radiative cooling process is adjusted through the incorporation of a phase change material (Vanadium Dioxide, VO2) in conjunction with a layer of transparent conductive oxide (Aluminum-doped Zinc Oxide, AZO). VO2 is known to undergo a phase transition from the “dielectric” phase to the “plasmonic” or “metallic” phase at a critical temperature close to 68°C. In addition, AZO shows plasmonic properties at the long-wave infrared spectrum, which, combined with VO2, provides a rich platform to achieve low reflections across the …


Nitric Oxide: Physiological Functions, Delivery, And Biomedical Applications, Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie Jun 2023

Nitric Oxide: Physiological Functions, Delivery, And Biomedical Applications, Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its gaseous form, NO has a short half-life, and its physiology role is concentration dependent, often restricting its function to a target site. Providing NO from an external source is beneficial in promoting cellular functions and treatment of different pathological conditions. Hence, the multifaceted role of NO in physiology and pathology has garnered massive interest in developing strategies to deliver exogenous NO for the treatment of various regenerative and biomedical …


On The Use Of Wireless Technologies For Wildlife Monitoring: Wireless Sensor Network Routing Protocols, Lilian Mutalemwa Jun 2023

On The Use Of Wireless Technologies For Wildlife Monitoring: Wireless Sensor Network Routing Protocols, Lilian Mutalemwa

Tanzania Journal of Engineering and Technology (TJET)

Traditional methods for wildlife monitoring are labor-intensive and time-consuming. Therefore, advanced technologies and remote monitoring methods are becoming increasingly popular. This paper presents a study on wireless technologies for wildlife monitoring. In the study, a review of the literature was done to identify the most commonly used wireless technologies. Various technologies were explored including unmanned aerial vehicles (UAVs), Internet of Things (IoT), wireless sensor networks (WSNs), artificial intelligence (AI), global positioning system (GPS), and very high frequency (VHF) radio. Then, a more detailed study was done on WSN technology. Investigations were done to observe the performance of routing protocols in …


Isolation And Performance Test Of Green Low Dosage Hydrate Inhibitors From Local Materials For Improving Flow Assurance In Oil And Gas Industry, Makungu Madirisha Jun 2023

Isolation And Performance Test Of Green Low Dosage Hydrate Inhibitors From Local Materials For Improving Flow Assurance In Oil And Gas Industry, Makungu Madirisha

Tanzania Journal of Engineering and Technology (TJET)

The formation of gas hydrates in oil and gas industry can be minimized or prevented by the use of inhibitors. This paper reports on hemicellulose and modified lignin as low dosage gas hydrate inhibitors (LDGHIs). LDGHIs were isolated from sugarcane bagasse (SCB), plant gum exudates (PGE) of Acacia trees, and coconut coir, and further characterized by Attenuated Total Reflectance - Fourier Transform Infrared (ATR-FTIR) spectrometer, porosimeter and thermogravimetric analyzer (TGA). The PGE and SCB yielded 77.75% and 12.38% of hemicellulose, respectively, while coconut coir yielded 35.59% of lignin which was modified to sodium lignosulfonate (SLS) to improve its solubility in …


Review On Modifications Of Sisal Fibers For Textile Applications, Liberato V Haule Jun 2023

Review On Modifications Of Sisal Fibers For Textile Applications, Liberato V Haule

Tanzania Journal of Engineering and Technology (TJET)

Properties of sisal fibers such as high coarseness and poor drapability made the fibers less suitable in production of conventional textiles compared to synthetic fibers. The environmental consciousness and depletion of petrochemical resources have attracted researchers on investigating the use of natural fibers in the industrial production of conventional textiles. Sisal is among highly researched natural fibers due to its features such as strength, recyclability, availability, low processing cost, light weight and ease process ability. This paper reviews possible modifications of sisal fibers to enhance performance in conventional textiles applications


Research And Development Of Intelligent Greenhouse Monitoring And Control System:A Review, Jiang Ru, Zhang Dong Jun 2023

Research And Development Of Intelligent Greenhouse Monitoring And Control System:A Review, Jiang Ru, Zhang Dong

Chemical Technology, Control and Management

Today, smart technologies are rapidly entering various areas of our lives. The role of intelligent technologies in the effective organization of control and management processes in the field of agriculture is incomparable. At the same time, intelligently controlled greenhouses are one of the main elements of agriculture. The article analyzes the importance of smart farming technologies associated with intelligent observing and control systems for greenhouses. These technologies include aspects such as the Internet of Things, artificial intelligence, and intelligent control. Based on the results of the analysis, prospects for the development of a monitoring and control system for a smart …


Characterization And Implementation Of An All-In-One Heating, Impedance, And Pulsing Device For Molecular Delivery Applications, Alex Otten Jun 2023

Characterization And Implementation Of An All-In-One Heating, Impedance, And Pulsing Device For Molecular Delivery Applications, Alex Otten

USF Tampa Graduate Theses and Dissertations

Cancer impacts millions of Americans every year, with an estimated 1.9 million new cases and 600,000 deaths predicted to occur in 2023 [1]. Medical professionals and scientists have developed several techniques and procedures to combat this disease including gene therapies, surgeries, and chemotherapies. Several of these techniques incorporate the use of pulsed electric fields to deliver molecular material to treat, or directly destroy, the cells of the tumor. These pulsed electric field techniques are known as gene electrotransfer, electrochemotherapy, and irreversible electroporation. All three techniques utilize different electrical parameters to achieve their target tumor reduction or expression goals. Efforts to …


Mass Spectrometry Of The White Adipose Metabolome In A Hibernating Mammal Reveals Seasonal Changes In Alternate Fuels And Carnitine Derivatives, Frazer I. Heinis, Sophie Alvarez, Matthew T. Andrews Jun 2023

Mass Spectrometry Of The White Adipose Metabolome In A Hibernating Mammal Reveals Seasonal Changes In Alternate Fuels And Carnitine Derivatives, Frazer I. Heinis, Sophie Alvarez, Matthew T. Andrews

Nebraska Center for Biotechnology: Faculty and Staff Publications

Mammalian hibernators undergo substantial changes in metabolic function throughout the seasonal hibernation cycle. We report here the polar metabolomic profile of white adipose tissue isolated from active and hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus). Polar compounds in white adipose tissue were extracted from five groups representing different timepoints throughout the seasonal activity-torpor cycle and analyzed using hydrophilic interaction liquid chromatography-mass spectrometry in both the positive and negative ion modes. A total of 224 compounds out of 660 features detected after curation were annotated. Unsupervised clustering using principal component analysis revealed discrete clusters representing the different seasonal timepoints throughout hibernation. One-way …


System-Characterized Artificial Intelligence Approaches For Cardiac Cellular Systems And Molecular Signature Analysis, Ziqian Wu Jun 2023

System-Characterized Artificial Intelligence Approaches For Cardiac Cellular Systems And Molecular Signature Analysis, Ziqian Wu

Dartmouth College Ph.D Dissertations

The dissertation presents a significant advancement in the field of cardiac cellular systems and molecular signature systems by employing machine learning and generative artificial intelligence techniques. These methodologies are systematically characterized and applied to address critical challenges in these domains. A novel computational model is developed, which combines machine learning tools and multi-physics models. The main objective of this model is to accurately predict complex cellular dynamics, taking into account the intricate interactions within the cardiac cellular system. Furthermore, a comprehensive framework based on generative adversarial networks (GANs) is proposed. This framework is designed to generate synthetic data that faithfully …


An Aptamer-Based Microelectrode With Tunable Linear Range For Monitoring Of K+ In The Living Mouse Brain, Yuan-Dong Liu, Jia-Run Li, Li-Min Zhang, Yang Tian Jun 2023

An Aptamer-Based Microelectrode With Tunable Linear Range For Monitoring Of K+ In The Living Mouse Brain, Yuan-Dong Liu, Jia-Run Li, Li-Min Zhang, Yang Tian

Journal of Electrochemistry

Potassium ion (K+) is widely involved in several physiopathological processes, and its abnormal changes are closely related to the occurrence of brain diseases of cerebral ischemia. In vivo acquirement of K+ variation is significant to understand the roles of K+ playing in brain functions. A microelectrode based on single-stranded DNA aptamers was developed for highly selective detection of K+ in brain, in which the aptamer probes were designed to contain an aptamer part for specific recognition of K+, an alkynyl group used for stable confinement of aptamer probe on the gold surface, and …


Colorful "Stars" In The Dark, Chao Jing, Yi-Tao Long Jun 2023

Colorful "Stars" In The Dark, Chao Jing, Yi-Tao Long

Journal of Electrochemistry

Plasmonic nanoparticles such as Au and Ag with localized surface plasmon resonance (LSPR) property exhibit unique scattering and absorption features. The plasmonic scattering and absorption bands are mainly located at visible light region which can be easily applied in visual detections. By modulating the size, shape, and composition of gold and silver colloid solutions, plenty of colorimetric methods have been constructed for the detection of metal ions, biomolecules, and environmental contaminants, etc. For many years, the LSPR-based measurements are implemented in reagent tubes. Since 2000, the plasmon resonance scattering (PRS) light of metal nanoparticles captured by dark-field microscopy enables the …