Digital Commons Network^™

From Data Digitization To Personalized Care: Deep Learning And Decision Analytics In Healthcare Systems, Ahla Ko

Graduate Theses and Dissertations

This dissertation traces a progression from foundational data infrastructure to individualized clinical decision-making, developing and evaluating three computational frameworks that advance healthcare efficiency and personalization through deep learning and decision analytics. The first study presents an end-to-end pipeline for automated recognition of handwritten medical forms, addressing persistent challenges in health data digitization. Integrating a YOLO-based field detection model, a Convolutional Recurrent Neural Network (CRNN) for text transcription, and a confidence-based human-in-the-loop quality assurance framework, the system achieved 99.75\% Exact Match Accuracy and a 0.13\% Character Error Rate on medical forms collected from a tuberculosis research project in Moldova. A GPU-accelerated …

Investigation Into The Effects Of Moderate-Dose Radiation On Ligament Biomechanics, Andrew Landefeld

All Theses

Recent advances in arthritis treatment pin ionizing X-ray radiation as a useful tool in reducing joint pain and immune response. However, due to a lack of fundamental research in the effects of low-dose ionizing radiation on tendon and ligament biomechanics, the safety of these studies is rather unknown. While most related studies investigated cellular response to low dose treatment, surrounding tissue physiology is left out of the picture. Additionally, moderate range doses of irradiation are rarely studied, as most uses of radiation on tendons and ligaments are for sterilization of cadaver tendons for allografts. This study provides a preliminary investigation …

Estimation Of The Mechanical Properties Of South Carolina Timber Piles Using Non-Destructive Evaluation Methods And Experimentally-Informed Models, Aashish Sapkota

All Theses

South Carolina has about 2,600 bridges that are supported by nearly 75,000 timber piles. They are increasingly vulnerable to biological decay, cracking and impact damages after decades of service. Current inspection methods used by the South Carolina Department of Transportation (SCDOT), such as hammer sounding and awl probing, are labor-intensive and expensive. This study investigated non-destructive evaluation (NDE) methods, including micro-resistance drilling and stress wave timing, as alternatives for assessing timber pile condition.

Ten timber piles were collected from two South Carolina bridges, and their above-grade portions were cut into 40 specimens approximately 13 to 15 inches long. Specimens were …

The Impact Of Dipeptides On Product Quality In Chinese Hamster Ovary Cells, Louise C. Herman

All Theses

Biopharmaceuticals are medicines produced in cells which are used to treat diseases such as cancer. Monoclonal antibodies (mAbs) represent the majority of approved biotherapeutics. MAbs are mostly produce using Chinese hamster ovary (CHO) cells. CHO cells are favored for resiliency, scalability, and established safety, and are considered the “workhorse” organism for biopharmaceuticals.  Amino acids are a key component of cell culture media, however several amino acids have solubility limits, such as cysteine, cystine, and tyrosine.  At neutral pH, these amino acids are poorly soluble.  However, dipeptides, such as N,N'-di-L-Alanyl-L-Cystine (ACCA) have been reported to increase cysteine and cystine availability. Further, …

Fluorescence-Based Quantification Of Hepatic Ldl Uptake And Donor Hepatocyte Engraftment Using Atto 700–Labeled Ldl, Victor Agustin Cortes Flores

All Theses

Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) that increases the risk of premature atherosclerotic cardiovascular disease. In severe FH, including low-density lipoprotein receptor (LDLR), hepatic LDL clearance is profoundly impaired and many lipid lowering treatment strategies have limited effectiveness. Current advances in ex vivo CRISPR–Cas9 hepatocyte gene editing in vivo and ex vivo approaches for treatment of FH are under development.

However, a central barrier to translation is the ability to quantitatively measure the percentage of healthy gen edited hepatocytes in the liver while simultaneously assessing functional hepatic LDL handling. This thesis establishes …

Exercise-Induced Muscle Damage As A Model For Exploring The Effects Of Pain On Gait, Sydney Savage

All Theses

Persistent gait asymmetry following anterior cruciate ligament reconstruction (ACLR) is a recognized contributor to post-traumatic knee osteoarthritis, yet the independent role of pain in driving altered movement patterns remains poorly understood due to confounding factors inherent to clinical populations. This study used exercise-induced muscle damage (EIMD) as a controlled experimental model to isolate the effects of musculoskeletal pain on gait, independent of kinesiophobia, structural damage, and proprioceptive disruption. Eighteen healthy adults underwent unilateral eccentric calf-raise protocols to induce delayed onset muscle soreness (DOMS), with gait assessed at baseline, 48 hours, and 168 hours post-exercise using bilateral inertial measurement units. Outcomes …

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

Undergraduate Design Spine For Biological Systems Engineering And Agricultural Engineering, David Mabie, Derek M. Heeren, Deepak R. Keshwani, Heidi A. Diefes-Dux, Nicole M. Iverson, Rachel Padrnos, Greg Bashford, Taryn King, Jenna Hefley, Curtis L. Tomasevicz

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Engineering education is undergoing a shift toward preparing graduates with demonstrated capabilities that integrate technical knowledge, durable skills, and the ability to adapt in a rapidly evolving professional landscape. This paper describes a comprehensive redesign of the undergraduate curriculum in Biological Systems Engineering (BSEN) and Agricultural Engineering (AGEN) at the University of Nebraska–Lincoln. The redesign is grounded in a “Design Spine” framework, which distributes and scaffolds design experiences across all four years of the program to support progressive development of problem solving, systems thinking, communication, and professional skills. The curriculum is organized around clearly defined capabilities and threads that connect …

Assessment Of Super Absorbent Polymer In Soybean Cultivation Under Variable Irrigation Conditions In Nebraska, Ankit Chandra, Abia Katimbo, Ronaldo Marchezan, Martha Nabaggala

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Water limitation is a primary constraint to soybean productivity in both irrigated and rainfed systems. Soil-applied superabsorbent polymers (SAPs) have been proposed as a strategy to buffer crops against episodic drought stress; however, their physiological and agronomic performance under varying irrigation regimes remains insufficiently quantified. Here, we evaluate three biodegradable polymer formulations: broader granules (BB), original granules (OG), and powder (PWR) applied at low (17.7 lb/ac) and high (120 lb/ac) rates under full (100% ET), reduced (50% ET), and no irrigation conditions in western Nebraska. Polymer application had negligible effects under full irrigation, with yields comparable to untreated controls. Under …

Analysis Of Potential Alkali Reactivity Of Aggregates In Arkansas, Brigita Dowling

Civil Engineering Undergraduate Honors Theses

Alkali Silica Reaction (ASR) is a deleterious chemical reaction in concrete that leads to the deterioration of concrete structures. This reaction occurs between minerals present in aggregates and alkalis in the cement, and produces a gel-like substance called alkali silicate gel. Gradually, these gels absorb water from the environment and expand, leading to internal stresses in the concrete. This damage results in expansion, cracking, and deformation, reducing the strength and durability of the concrete significantly. While this damage appears minor initially, eventually they can lead to the need for costly repairs or replacement of the concrete. ASR has been observed …

Dor-E: Final Design Report, Arav Singh, August Hogen-Esch, Bruce Le, Patrick Mcgee, Spencer Major

Mechanical Engineering

I. PROBLEM STATEMENT

The Chumash Heritage National Marine Sanctuary contains a diverse array of benthic habitats that remain largely undocumented due to the financial and logistical barriers of deep-sea exploration. Traditional high-end autonomous underwater vehicles and remotely operated vehicles capable of reaching 1000-meter depths require significant surface support infrastructure and hundreds of thousands of dollars in funding. Furthermore, navigating protected ecological zones demands strict adherence to "Leave No Trace" principles. Conventional benthic landers and submersibles routinely leave metallic debris behind; many submersibles use galvanic timed releases that corrode in seawater over a set period of time or heat-activated bolts to …

Ihelp Foundation 2025 Uganda Medical Mission, Kade Spencer Robison

Undergraduate Honors Capstone Projects

Uganda faces significant barriers to health care access, particularly in rural communities, due to physician shortages and limited resources. As a result, care is concentrated in urban areas, leaving rural populations disproportionately affected by both communicable and noncommunicable diseases.

This Honors Capstone project focused on preparing for and supporting the iHelp Foundation’s 2025 Uganda Medical Mission. The iHelp Foundation works to reduce barriers to care in Uganda by partnering with local hospitals to provide short-term rural clinics and specialized surgical care for advanced otolaryngological conditions.

In this project, I contributed to mission preparation by training volunteers and coordinating physician licensing. …

Generative Ai Of Breast Cancer Progression In Gene Expression Space, Xusheng Ai

All Dissertations

Breast cancer is one of the most common and deadly cancers in the world. Although doctors can use gene activity data to better understand different types of breast cancer, it is still difficult to identify the most important genes and to track how the disease changes over time. This is partly because gene data are very large and complex.

This dissertation develops a computer-based framework to study breast cancer using gene expression data. The work focuses on three goals: creating realistic synthetic gene data, identifying important genes linked to cancer, and modeling how breast cancer changes from normal tissue to …

Investigation Of Low-Pressure Mercury Lamp System Configurations And Xenon Excimer Lamp System Development As Vacuum Ultraviolet Sources For Optimal Photolytic Degradation Of Poly-/Perfluoroalkyl Substances, Eman Zuhair Alhamdan

All Dissertations

PFAS are persistent synthetic chemicals, with unique properties that enable them to easily enter and accumulate in water sources. Their public health impacts have raised concern and highlighted the need for effective treatment. Numerous techniques for PFAS removal from water have been studied, few have proven the ability of breaking down PFAS rather than separating and concentrating it. Many of these methods are chain-length dependent, showing slower degradation rate of short-chain PFAS and requiring substantial amounts of energy, and chemical agents that may produce byproducts.

Among available PFAS destruction methods, direct photolysis by high-energy UV with wavelength below 200 nm …

Learning Global Context For Sparse Activity Recognition In Lengthy Recordings With Limited Dataset Size, Zeyu Tang

All Dissertations

This dissertation describes methods to analyze lengthy recordings of data in order to detect sparsely occurring activities. The narrative below describes the progression of research that led to the development of these methods and their generalization into a unified framework. My research started with designing models for dietary monitoring, including detecting meals from day-long recordings and detecting intake gestures from meal-length recordings. Both tasks share some common characteristics: (a) the target event takes only a small portion of data recordings, and (b) there is global context within full-length data recordings that can help a model make better decisions. After finishing …

Baseline Cervical Intervertebral Disc Biomechanics And Implications For Allograft Preservation, Nathan F. Buchweitz

All Dissertations

Neck pain has become an increasingly common orthopaedic healthcare issue. Evidence shows that degeneration of cervical intervertebral discs (the cartilage between the spinal vertebrae in the neck) may be associated. While disc degeneration in the lumbar spine has been extensively studied in relation to low back pain, it has received less attention in the cervical spine. Biomechanically, the cervical (neck) and lumbar (lower back) regions of the spine differ in function. Lumbar discs resist a greater burden of body weight, whereas cervical discs are adapted for mobility to aid flexible head orientation. Despite these key differences, disc injury and degeneration …

Porous Hydrophobic Adsorbent Coatings For Carbon Dioxide Capture, Samuel Babatunde Olushola

Theses and Dissertations

This work presents the development of a porous, hydrophobic zeolite 13X coating for the separation of carbon dioxide (CO₂) from flue gas or natural gas. Zeolite 13X was combined with yeast, glucose, and sodium alginate as pore-forming agents, and with polytetrafluoroethylene (PTFE) and Polydimethylsiloxane (PDMS) as hydrophobicity-inducing agents to enhance water resistance while maintaining CO₂ access to the adsorbent. The study explored PTFE/13X mass ratios ranging from 0 to 2.33 to investigate the interplay between hydrophobicity and CO₂ uptake. The wettability of the coating was characterized by using a temporal water contact angle (WCA) measurement. Increasing …

Retrospective Analysis Of Implemented Project Management Within A Small-Scale Student Engineering Project: Beng Fountain Wars Team Case Study, Holli E. Jenkins

Biological and Agricultural Engineering Undergraduate Honors Theses

This honors thesis provides a retrospective analysis of how the 2025 inaugural University of Arkansas’s ASABE Fountain Wars Student Team could be improved through project management. Project commitment, early stakeholder influence, rich communication, and a detailed project plan are all attributes of successful projects, and the team’s strengths and weaknesses within these categories were determined through a team poll. After the poll was conducted, three methodologies, Agile, Hybrid, and Waterfall, were assessed to determine how they would effectively address the team’s weaknesses. A weighted objectives table was created to compare each methodology’s effectiveness across the management categories. The analysis revealed …

Enhancing Food Security In Stann Creek, Belize Using Meat Rabbits: Engineering Perspective, Lindsey Garretson

Biological and Agricultural Engineering Undergraduate Honors Theses

The purpose of this paper is to discuss the engineering perspective within the overall project of using meat rabbits to enhance food security and nutrition within Stann Creek, Belize. From the engineering perspective, the overarching goals were like the overarching project goals including the construction and materials required guide within the manual, designing potential upgrades to the design including a solar and battery system and an automatic watering system, and to design the system to be “practically sustainable” where possible. The constraints for this project included cost, the size of land dedicated for the rabbitry, and the operational and environmental …

Electrical Resilience In Water Treatment Plants: An Extreme Weather And Lightning Protection Study, Genesis Martinez

Theses and Dissertations

Water treatment plants (WTPs) are vital infrastructure systems that depend on sensitive electrical, electronic, and control equipment to ensure the continuous supply of safe drinking water and effective wastewater treatment. As global temperatures rise and climate change accelerates, the frequency and intensity of extreme weather events—such as hurricanes, flooding, and increased lightning activity—are becoming more pronounced. These events pose significant risks to the electrical resilience of water treatment facilities, often leading to power outages, equipment failures, grid instability, and prolonged service disruptions. This report explores the impacts of extreme weather, with a particular focus on lightning and electrical surges, on …

An Investigation Of Data Granularity In Rag Pipelines For Personalized Medicine, Paritosh Pandey

Master's Theses

Generative AI, exemplified by large language models like the OpenAI GPT and Meta LLaMA families, can produce diverse content in response to prompts. This capability offers a promising solution to challenges in precision medicine, which seeks to tailor treatments to individual clinical profiles but often struggles with data collection, cost, and privacy concerns. By generating realistic, privacy-preserving patient data, generative AI has the potential to transform patient-centric healthcare. With such motivation, this research develops a comprehensive Generative AI pipeline emphasizing data granularity for accurate prediction of personalized treatments. The pipeline features a central Large Language Model interacting with a Machine …

Simulation Of A Buried Hydrogen Pipeline In Kansas State Soil, Sidney Hines

Master's Theses

Underground pipelines can be used to transport large amounts of pressurized hydrogen gas over several hundred kilometers. The design will be sensitive to the pipe material, diameter, and trench construction, and traffic loads above the pipe. The purpose of this paper is to conduct various geotechnical engineering analyses (seepage, stress, and slope stability) using the software program GeoStudio (version 2025.2.0) on a buried steel or FRP pipe section in a specific soil type, Harney Soil. Harney soil is of particular interest, because it is the Kansas State Soil and the analysis is for a buried gas pipe to run through …

Manned Exploration Of Satellites Of The Outer Planets: An Analysis Of Current Technologies And A Discussion Of Advancements Required, Joshua Carson Meador

Theses and Dissertations

The Solar System’s outer planets have many satellites, some of which are known to be the most likely places to find extraterrestrial life in our celestial backyard. Multiple scientific missions have been sent to glean information from these satellites, yet the possibility of a manned expedition has long been exclusive to science fiction stories. This paper intends to collect and analyze the current state of space travel technology to explore the feasibility of such a mission with modern technology and to discuss which future advancements should be the focal point for making such missions a reality. To begin, data on …

Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante

Theses and Dissertations

This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …

Developing Transparent Sustainability Data Systems In A Poultry And Pet Food Company: An Internship Case Study, Catherine L. Warren

Biological and Agricultural Engineering Undergraduate Honors Theses

My honors thesis examined my internship experiences and its implications on sustainability data gathering and reporting in poultry and pet food companies. It highlighted my internship projects, the skills I developed, and the connections to sustainability data transparency and reliability in a corporate environment.

In my thesis, I shared details about my internship. I described what projects I worked on, the places I visited, the hands-on experience I gained, and the different teams I worked with throughout the internship duration. I discussed the analytic and professional skills I developed through conducting a waste audit, developing Tableau dashboards, and helping to …

Design And Performance Overview Of The Inaugural University Of Arkansas Beng Fountain Wars Team, Autumn Jones

Biological and Agricultural Engineering Undergraduate Honors Theses

This honors thesis describes the engineering design process for the first ASABE Fountain Wars submission by a student team at the University of Arkansas in over a decade. Fountain Wars has a technical and aesthetic task, and the focus of this thesis is the design of the technical task. In 2025, this task was the “shoot out.” The objective was to get objects from a small pool into two 5-gallon buckets 10-15 feet away. The power for initiating the launch had to be provided by the pump. The objects were required to start at the surface of the water.

The …

Dried Water Treatment Residuals Might Be An Option To Reduce Soluble Reactive Phosphorus Release From Soils, Katie B. Mckay

Biological and Agricultural Engineering Undergraduate Honors Theses

Nonpoint source pollution from agricultural landscapes contributes to freshwater eutrophication, with legacy phosphorus (P) in soils potentially driving soluble reactive phosphorus (SRP) losses to surface waters. The objectives of this study were to evaluate SRP adsorption by dried water treatment residuals (WTRs) produced by Beaver Water District, quantify reductions in soil SRP release across increasing WTR application rates, and compare dried WTR performance to prior WTR studies.

Dried WTRs (~98% solids) were assessed using batch sorption experiments and soil core incubations. Phosphorus sorption was measured by mixing WTRs with CaCl₂ solutions containing increasing SRP concentrations and fitting results to …

Monitoring Streambank Morphology Using Iphone Lidar Technology, Lily C. Stitt

Biological and Agricultural Engineering Undergraduate Honors Theses

Monitoring stream morphology is crucial for maintaining the health and safety of fluvial environments, particularly as these naturally dynamic systems are shifted out of equilibrium due to climate and land-use change. Quantifying changes in stream geometry are useful for infrastructure design, water quality assessment, water resource management, and stream restoration, among other applications. Traditional stream surveying methods contain numerous cost limitations that inhibit affordable and accessible stream surveying needed for evaluating stream geometry with high accuracy and larger spatial scales (>100s of ). In recent years, several advancements have been made in the use of Light Detection and Ranging …

Cross-Facility Reliable Deep Learning Based Beef Marbling Assessment Via Unsupervised Domain Adaptation Regression, Samuel Vinson

Biological and Agricultural Engineering Undergraduate Honors Theses

Inconsistent quality grading in beef production leads to inefficiencies, economic disparity, and consumer mistrust. While USDA meat grading traditionally relies on skilled visual inspectors, these human evaluations suffer from cross-facility variability and subjectivity. This paper introduces the first known application of unsupervised domain adaptation regression for cross-facility beef marbling score prediction—an innovation that improves generalization across diverse environments in the beef supply chain. Utilizing numerical scores ranging from 100-900, the research employed convolutional neural networks (CNNs), including ResNet, VGG, and AlexNet architectures. The study specifically introduced and validated a unified unsupervised domain adaptation regression method using the ResNet-50 architecture to …

Uav-Based Sensor Integration For In-Situ Lake Water Quality Monitoring, Alec R. Campbell

Biological and Agricultural Engineering Undergraduate Honors Theses

Surface water monitoring is often constrained by limited spatial and temporal coverage due to the labor-intensive nature of traditional sampling methods, particularly in environments that are difficult to access or pose safety risks. Unmanned aerial vehicles (UAVs) offer a promising solution by enabling more frequent, spatially distributed, and cost-effective data collection. This study presented the design, development, and field evaluation of a UAV-based system for real-time, in-situ water quality monitoring. The system integrated multiple sensors, including oxidation-reduction potential (ORP), RGB spectrometry, pH, electrical conductivity (EC), dissolved oxygen (DO), and a multispectral spectrometer within a UAV platform.

Field testing was conducted …