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Resolving Structure And Mechanical Properties At The Nanoscale Of Viruses With Frequency Modulation Atomic Force Microscopy, David Martinez-Martin, Carolina Carrasco, Mercedes Hernando-Perez, Pedro J. De Pablo, Julio Gomez-Herrero, Rebeca Perez, Mauricio G. Mateu, Jose L. Carrascosa, Daniel Kiracofe, John Melcher, Arvind Raman

Birck and NCN Publications

Structural Biology (SB) techniques are particularly successful in solving virus structures. Taking advantage of the symmetries, a heavy averaging on the data of a large number of specimens, results in an accurate determination of the structure of the sample. However, these techniques do not provide true single molecule information of viruses in physiological conditions. To answer many fundamental questions about the quickly expanding physical virology it is important to develop techniques with the capability to reach nanometer scale resolution on both structure and physical properties of individual molecules in physiological conditions. Atomic force microscopy (AFM) fulfills these requirements providing images …

Ceas E-News 01.24.2012, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

Engineers Week, TAPPI Award Winner, Career Fair, Monroe-Brown Internships

Characterization And Biomechanical Analysis Of The Human Lumbar Spine With In Vitro Testing Conditions, Dean K. Stolworthy

Theses and Dissertations

Biomechanical testing of cadaveric spinal segments forms the basis for our current understanding of healthy, pathological, and surgically treated spinal function. Over the past 40 years there has been a substantial amount of data published based on a spinal biomechanical testing regimen known as the flexibility method. This data has provided valuable clinical insights that have shaped our understanding of low back pain and its treatments. Virtually all previous lumbar spinal flexibility testing has been performed at room temperature, under very low motion rates, without the presence of a compressive follower-load to simulate upper body weight and the action of …

Energy-Based Yield Criterion For Pmma From Large-Scale Molecular Dynamics Simulations, Eugenio Jaramillo, Nathaniel Wilson, Stephen Christensen, Jonathan Gosse, Alejandro Strachan

Birck and NCN Publications

We use molecular dynamics (MD) with the DREIDING force field to characterize the ultimate mechanical response of amorphous poly(methyl methacrylate). We characterize how volumetric and deviatoric strains contribute to yield for a wide range of loading conditions from pure deviatoric, volume-conserving cases to isotropic volume expansion. We propose and apply an energy-based yield criterion to define yield consistently for all cases. Our results show that permanent deformation occurs when either the deviatoric or volumetric strains reach critical values, except in a narrow region around the transformation between deviatoric- and volumetric-dominated yield where the two strain invariants interact. In contrast, the …

Optimally Enhanced Optical Emission In Laser-Induced Breakdown Spectroscopy By Combining Spatial Confinement And Dual-Pulse Irradiation, L. B. Guo, B. Y. Zhang, X. N. He, C. M. Li, Y. S. Zhou, T. Wu, J. B. Park, X. Y. Zeng, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

In laser-induced breakdown spectroscopy (LIBS), a pair of aluminum-plate walls were used to spatially confine the plasmas produced in air by a first laser pulse (KrF excimer laser) from chromium (Cr) targets with a second laser pulse (Nd:YAG laser at 532 nm, 360 mJ/pulse) introduced parallel to the sample surface to re-excite the plasmas. Optical emission enhancement was achieved by combing the spatial confinement and dual-pulse LIBS (DP-LIBS), and then optimized by adjusting the distance between the two walls and the interpulse delay time between both laser pulses. A significant enhancement factor of 168.6 for the emission intensity of the …

Sheathless Size-Based Acoustic Particle Separation, Rasim Guldiken, Myeong Chan Jo, Nathan D. Gallant, Utkan Demirci, Jiang Zhe

Mechanical Engineering Faculty Research

Particle separation is of great interest in many biological and biomedical applications. Flow-based methods have been used to sort particles and cells. However, the main challenge with flow based particle separation systems is the need for a sheath flow for successful operation. Existence of the sheath liquid dilutes the analyte, necessitates precise flow control between sample and sheath flow, requires a complicated design to create sheath flow and separation efficiency depends on the sheath liquid composition. In this paper, we present a microfluidic platform for sheathless particle separation using standing surface acoustic waves. In this platform, particles are first lined …

The Nucleus 2011-2012, Rosalie A. Richards

Science Education Center

No abstract provided.

Altering Iron Oxide Nanoparticle Surface Properties Induce Cortical Neuron Cytotoxicity, Christopher J. Rivet, Yuan Yuan, Diana Andra Borca-Tasciuc, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Superparamagnetic iron oxide nanoparticles, with diameters in the range of a few tens of nanometers, display the ability to cross the blood-brain barrier and are envisioned as diagnostic and therapeutic tools in neuro-medicine. However, despite the numerous applications being explored, insufficient information is available on their potential toxic effect on neurons. While iron oxide has been shown to pose a decreased risk of toxicity, surface functionalization, often employed for targeted delivery, can significantly alter the biological response. This aspect is addressed in the present study, which investigates the response of primary cortical neurons to iron oxide nanoparticles with coatings frequently …

Simple Optimization Method To Determine Best Management Practices To Reduce Phosphorus Loading In Echo Reservoir, Utah, Omar Alminagorta, Bereket Tesfatsion, David E. Rosenberg, Bethany T. Neilson

Civil and Environmental Engineering Faculty Publications

This study develops and applies a simple linear optimization program to identify cost effective Best Management Practices (BMPs) to reduce phosphorus loading to Echo Reservoir, Utah. The optimization program tests the feasibility of proposed Total Maximum Daily Load (TMDL) allocations based on potential BMP options and provides information regarding the spatial redistribution of loads among sub-watersheds. The current version of the TMDL for Echo reservoir allocates phosphorus loads to existing non-point phosphorus sources in different sub-watersheds to meet a specified total load. Optimization results show that it is feasible to implement BMPs for non-point sources in each sub-watershed to meet …

Is Adding The E Enough?: Investigating The Impact Of K-12 Engineering Standards On The Implementation Of Stem Integration., Gillian H. Roehrig, Tamara J. Moore, Hui-Hui Wang, Mi Sun Park

School of Engineering Education Faculty Publications

The problems that we face in our ever-changing, increasingly global society are multidisciplinary, and many require the integration of multiple science, technology, engineering, and mathematics (STEM) concepts to solve them. National calls for improvement of STEM education in the United States are driving changes in policy, particularly in academic standards. Research on STEM integration in K-12 classrooms has not kept pace with the sweeping policy changes in STEM education. This study addresses the need for research to explore the translation of broad, national-level policy statements regarding STEM education and integration to state-level policies and implementation in K-12 classrooms. An interpretive …

Multi-Scale Gis Data-Driven Method For Early Assessment Of Wetlands Impacted By Transportation Corridors, Rodrigo Nobrega, Colin Brooks, Charles O'Hara, Bethany Stich

Michigan Tech Research Institute Publications

No abstract provided.

Mse Annual Report 2012, Department Of Materials Science And Engineering, Michigan Technological University

Department of Materials Science and Engineering Annual Reports

Table of Contents

• What's that Sound? Wind Harp Brings New Beauty to Campus
• Yongmei Jin and Yu Wang: The MSE Dynamic Duo
• MSE Researcher Creates Better Solar Cells
• Faculty and Staff News
• Updates and Awards
• Alumni at a Glance

Treatment Of Osteoporosis In A Mouse Model Of Duchenne Muscular Dystrophy Using Black Bear Parathyroid Hormone, Sarah K. Gray

Dissertations, Master's Theses and Master's Reports - Open

Duchenne muscular dystrophy (DMD) is a progressive disease affecting skeletal and cardiac muscle, as well as bone. Long term disuse and glucocorticoid treatments cause progressive osteoporosis in DMD patients, leading to an increase in fracture incidence. Treatments for osteoporosis in these patients have not been widely explored. Parathyroid hormone (PTH), an anabolic treatment for post-menopausal osteoporosis, could benefit DMD patients by improving skeletal properties and reducing fracture risk. Other PTH analogues are not currently FDA approved to treat osteoporosis, but may have improved osteogenic effects compared to the human analogue. Black bear PTH is especially promising as an osteoporosis treatment …

Engineering Research 2012, College Of Engineering, Michigan Technological University

Michigan Tech Engineering Magazine

Table of Contents

• Energy
• Engineered Materials
• Health
• Education & Outreach
• Earth & Water
• People

Impact Of Lifetime On U.S. Residential Building Lca Results, Can B. Aktas, M. M. Bilec

Civil Engineering Faculty Publications

Purpose: Many life cycle assessment (LCA) studies do not adequately address the actual lifetime of buildings and building products, but rather assume a typical value. The goal of this study was to determine the impact of lifetime on residential building LCA results. Including accurate lifetime data into LCA allows a better understanding of a product’s environmental impact that would ultimately enhance the accuracy of LCA results.

Methods This study focuses on refining the U.S. residential building lifetime, as well as lifetime of interior renovation products that are commonly used as interior finishes in homes, to improve LCA results. Residential building …

An Open-Source Sandbox For Increasing The Accessibility Of Functional Programming To The Bioinformatics And Scientific Communities, Matthew Fenwick, Colbert Sesanker, Jay Vyas, Michael R. Gryk

UCHC Articles - Research

Scientists are continually faced with the need to express complex mathematical notions in code. The renaissance of functional languages such as LISP and Haskell is often credited to their ability to implement complex data operations and mathematical constructs in an expressive and natural idiom. The slow adoption of functional computing in the scientific community does not, however, reflect the congeniality of these fields. Unfortunately, the learning curve for adoption of functional programming techniques is steeper than that for more traditional languages in the scientific community, such as Python and Java, and this is partially due to the relative sparseness of …

Conference Program, David Elad

Computational Fluid Dynamics (CFD) in Medicine And Biology in Conjunction With the Seventh International Biofluid Mechanics Symposium

No abstract provided.

A Critical Review On Corrosion Of Compression Ignition (Ci) Engine Parts By Biodiesel And Biodiesel Blends And Its Inhibition, B. Singh, John Korstad, Y. C. Sharma

College of Science and Engineering Faculty Research and Scholarship

This paper reviews the effects of corrosion on the engine parts that come in contact with a newly developed biodiesel fuel and its petrodiesel blend. Copper, aluminum, copper alloys (bronze), and elastomers caused significant levels of corrosiveness in biodiesel and biodiesel blend as opposed to low corrosion with petrodiesel. Specimens of stainless steel showed significant resistance to corrosion in biodiesel samples as compared to copper, aluminum, and copper alloys, but the level of corrosion was still higher than that in petrodiesel. Common methods adopted for measurement of corrosion include weight loss through static emersion tests, and electrochemical techniques by electrochemical …

Analysis Of Embryoid Bodies Derived From Human Induced Pluripotent Stem Cells As A Means To Assess Pluripotency, Steven D. Sheridan, Vasudha Surampudi, Raj R. Rao

Chemical and Life Science Engineering Publications

Human induced pluripotent stem cells (hiPSCs) have core properties of unlimited self-renewal and differentiation potential and have emerged as exciting cell sources for applications in regenerative medicine, drug discovery, understanding of development, and disease etiology. Key among numerous criteria to assess pluripotency includes the in vivo teratoma assay that has been widely proposed as a standard functional assay to demonstrate the pluripotency of hiPSCs. Yet, the lack of reliability across methodologies, lack of definitive clinical significance, and associated expenses bring into question use of the teratoma assay as the “gold standard” for determining pluripotency. We propose use of the in …

Development And Application Of A Hydroclimatological Stream Temperature Model Within The Soil And Water Assessment Tool, Darren L. Ficklin, Yuzhou Luo, Iris T. Stewart-Frey, Edwin P. Maurer

Civil, Environmental and Sustainable Engineering

We develop a stream temperature model within the Soil and Water Assessment Tool (SWAT) that reflects the combined influence of meteorological (air temperature) and hydrological conditions (streamflow, snowmelt, groundwater, surface runoff, and lateral soil flow) on water temperature within a watershed. SWAT currently uses a linear air-stream temperature relationship to determine stream temperature, without consideration of watershed hydrology. As SWAT uses stream temperature to model various in-stream biological and water quality processes, an improvement of the stream temperature model will result in improved accuracy in modeling these processes. The new stream temperature model is tested on seven coastal and mountainous …

Low-Tech Coconut Shell Activated Charcoal Production, Ami Cobb, Mikel Warms, Edwin P. Maurer, Steven Chiesa

Civil, Environmental and Sustainable Engineering

Water treatment technologies in the developing world typically focus on removing two types of impurities from water sources: suspended solids and microbial pathogens. However, as industrialization and high-input agriculture has expanded into the developing world, chemical impurities such as pesticides, herbicides, and fertilizers have found their way into drinking water supplies and have been linked to severe health-related issues. Activated carbon has the capacity to remove these problematic chemicals from water sources. A simple, inexpensive, and effective activated carbon production process using local agricultural waste byproducts was assessed for the community of Bluefields, Nicaragua. Coconut shell charcoal was produced on …

Groundwater Quality And Its Health Impact: An Assessment Of Dental Fluorosis In Rural Inhabitants Of The Main Ethiopian Rift, Tewodros Rango, Julia Kravchenko, Behailu Atlaw, Peter G. Mccornick, Marc Jeuland, Brittany Merola, Avner Vengosh

Daugherty Water for Food Global Institute: Faculty Publications

This study aims to assess the link between fluoride content in groundwater and its impact on dental health in rural communities of the Ethiopian Rift. A total of 148 water samples were collected from two drainage basins within the Main Ethiopian Rift (MER). In the Ziway-Shala basin in particular, wells had high fluoride levels (mean: 9.4 ± 10.5 mg/L; range: 1.1 to 68 mg/L), with 48 of 50 exceeding the WHO drinking water guideline limit of 1.5 mg/L. Total average daily intake of fluoride from drinking groundwater (calculated per weight unit) was also found to be six times higher than …

Controlled Delivery Of Tgf-Ss1 From Plga Nanoparticles, Pratik K. Vaidya

ETD Archive

Abdominal aortic aneurysms (AAAs) typically manifest as localized wall weakening and dilation of the infrarenal aorta, which grows gradually, and ultimately leads to fatal rupture. It is caused due to overexpression of proteolytic enzymes (matrix metalloproteases or MMPs) resulting into disruption of tissue structure, especially elastic matrix, which cannot be regenerated by adult vascular cells. On account of post-operative complications associated with their surgical repair, there is a critical need for developing non-surgical strategies for slowing and even regressing AAA growth. Recent studies in our laboratory have demonstrated that 1 ng/mL of transforming growth factor-β1 (TGF-β1) enhances regenerative repair by …

Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich

ETD Archive

No abstract provided.

Fracture Detection In Traumatic Pelvic Ct Images, Jie Wu, Pavani Davuluri, Kevin R. Ward, Charles Cockrell, Rosalyn H. Hargraves, Kayvan Najarian

Computer Science Publications

Fracture detection in pelvic bones is vital for patient diagnostic decisions and treatment planning in traumatic pelvic injuries. Manual detection of bone fracture from computed tomography (CT) images is very challenging due to low resolution of the images and the complex pelvic structures. Automated fracture detection from segmented bones can significantly help physicians analyze pelvic CT images and detect the severity of injuries in a very short period. This paper presents an automated hierarchical algorithm for bone fracture detection in pelvic CT scans using adaptive windowing, boundary tracing, and wavelet transform while incorporating anatomical information. Fracture detection is performed on …

An Automated Optimal Engagement And Attention Detection System Using Electrocardiogram, Ashwin Belle, Rosalyn H. Hargraves, Kayvan Najarian

Computer Science Publications

This research proposes to develop a monitoring system which uses Electrocardiograph (ECG) as a fundamental physiological signal, to analyze and predict the presence or lack of cognitive attention in individuals during a task execution. The primary focus of this study is to identify the correlation between fluctuating level of attention and its implications on the cardiac rhythm recorded in the ECG. Furthermore, Electroencephalograph (EEG) signals are also analyzed and classified for use as a benchmark for comparison with ECG analysis. Several advanced signal processing techniques have been implemented and investigated to derive multiple clandestine and informative features from both these …

Mineralization Potential Of Electrospun Pdo-Hydroxyapatite-Fibrinogen Blended Scaffolds, Isaac Rodriguez, Parthasarathy A. Madurantakam, Jennifer M. Mccool, Scott A. Sell, Hu Yang, Peter C. Moon, Gary L. Bowlin

Biomedical Engineering Publications

The current bone autograft procedure for cleft palate repair presents several disadvantages such as limited availability, additional invasive surgery, and donor site morbidity. The present preliminary study evaluates the mineralization potential of electrospun polydioxanone:nano-hydroxyapatite : fibrinogen (PDO : nHA : Fg) blended scaffolds in different simulated body fluids (SBF). Scaffolds were fabricated by blending PDO : nHA : Fg in the following percent by weight ratios: 100 : 0 : 0, 50 : 25 : 25, 50 : 50 : 0, 50 : 0 : 50, 0 : 0 : 100, and 0 : 50 : 50. Samples were immersed …

A Preliminary Study On The Potential Of Manuka Honey And Platelet-Rich Plasma In Wound Healing, Scott A. Sell, Patricia Wolfe, Andrew J. Spence, Isaac Rodriguez, Jennifer M. Mccool, Rebecca L. Petrella, Koyal Garg, Jeffery J. Ericksen, Gary L. Bowlin

Biomedical Engineering Publications

Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, …

Optical And Structural Studies Of Homoepitaxially Grown M-Plane Gan, S. Khromov, B. Monemar, Vitaliy Avrutin, Xing Li, Hadis Morkoç, L. Hultman, G. Pozina

Electrical and Computer Engineering Publications

Cathodoluminescence(CL) and transmission electron microscopy studies of homoepitaxiallygrownm-plane Mg-doped GaN layers are reported. Layers contain basal plane and prismatic stacking faults (SFs) with ∼10⁶cm⁻¹ density. Broad emission peaks commonly ascribed to SFs were found to be insignificant in these samples. A set of quite strong, sharp lines were detected in the same spectral region of 3.36–3.42 eV. The observed peaks are tentatively explained as excitons bound to some impurity defects, which can also be related to SFs. Donor-acceptor pair (DAP) recombination involving Si or O and Mg was ruled out by fitting DAP energies and …

Comprehensive Solution To Scattering By Bianisotropic Objects Of Arbitrary Shape, Chong Mei, Moamer Hasanovic, Jay K. Lee, E. Arvas

Electrical Engineering and Computer Science - All Scholarship

This paper presents a method of moments (MoM) solution for the problems of electromagnetic scattering by inhomogeneous three- dimensional bianisotropic scatterers of any shape. The electromagnetic response of bianisotropy has been described by the constitutive relations of the most general form composed of four 3 £ 3 matrices or tensors. The volume equivalence principle is used to obtain a set of mixed potential formulations for a proper description of the original scattering problem. Here, the total ¯elds are separated into the incident ¯elds and the scattered ¯elds. The scattered ¯elds are related to the electric and magnetic potentials which are …