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Folate Nanoparticle Conjugates, Safwat A. Masood

All Capstone Projects

The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate …

Pineapple Liquid Waste As Nata De Pina Raw Material, Agus Sutanto

Makara Journal of Technology

This research aims to study the quantity, quality, ecological and economic feasibility of nata de pina production (NP) from pineapple liquid waste (PLW). The design of the study employs complete random design (CRD) with three treatments: PLW without nutrients addition (A), PLW nutrients addition (B), and PLW stored for six months with nutrients addition (C). The nata de pina’s production factors measured were weight, thickness, fiber content, color, brightness, and residual waste. The highest weight was reached in treatment B (899 grams), followed by treatment A (616.4 grams), and C (477.8 grams). The thickness of NP of the height and …

The Influence Of Heterogeneous Meninges On The Brain Mechanics Under Primary Blast Loading, Linxia Gu, Mehdi S. Chafi, Shailesh Ganpule, Namas Chandra

Department of Mechanical and Materials Engineering: Faculty Publications

In the modeling of brain mechanics subjected to primary blast waves, there is currently no consensus on how many biological components to be used in the brain–meninges–skull complex, and what type of constitutive models to be adopted. The objective of this study is to determine the role of layered meninges in damping the dynamic response of the brain under primary blast loadings. A composite structures composed of eight solid relevant layers (including the pia, cerebrospinal fluid (CSF), dura maters) with different mechanical properties are constructed to mimic the heterogeneous human head. A hyper-viscoelastic material model is developed to better represent …

Nuts And Bolts: Newsletter 45 - Issue 1 - Spring 2012

Friends of the Larsen Tractor Museum

Friends of the Larsen Tractor Museum-An Update! by Don Edwards

Our Chinese tractor: How it got here by Lou Leviticus

Section Abstracts: Astronomy, Mathematics And Physics With Materials Science

Virginia Journal of Science

Abstracts of the Astronomy, Mathematics, and Physics with Material Science Section for the 90th Annual Meeting of the Virginia Academy of Science, May 23-25, 2012, Norfolk State University, Norfolk, Virginia

Estimating Connecticut Stream Temperatures Using Predictive Models, Erik Carlson

Honors Theses and Capstones

The Connecticut Department of Energy and Environmental Protection (CT DEEP) seeks to better classify their streams into thermal regimes (cold, cold transitional, warm transitional, and warm water). A prediction model was created based upon physical characteristics such that CT DEEP could classify streams into thermal regimes based upon the parameters described in Lyons et al. 2009 and compare them to their own classification system. Accurately classifying these thermal regimes determines the environmental protection provided to a stream as well as the potential for establishing fisheries.

Cs 271/Bio 371: Introduction To Bioinformatics, Michael L. Raymer, Dan E. Krane

Computer Science & Engineering Syllabi

No abstract provided.

Reducing The Radiation Dose To Women Receiving Cardiac Ct Scans, Michael Hoppe

Master's Theses (2009 -)

This thesis aims to quantify the reduction in radiation dose deposited in glandular breast tissue achieved by using tilted gantry acquisition during cardiac CT scans. Previous work by Halpern et al. suggested using tilted acquisition parallel to the long axis of the patient’s heart. However, for a larger portion of the population this is not feasible due to the design of current scanners (which are limited to maximum tilt angles of 30 degrees). This study investigated the potential dose reduction and image quality effects at commercially available tilt angles between 0-30 degrees through simulation and experimental studies.

Upon IRB approval, …

Quantifying The Impact Of Altered Hemodynamics And Vascular Biomechanics To Changes In Structure And Function In Native And Corrected Aortic Coarctation, Arjun Menon

Dissertations (1934 -)

Coarctation of the aorta (CoA) is associated with substantial cardiovascular morbidities despite successful treatment through surgical or catheter-based intervention. Although specific mechanisms leading to these morbidities remain elusive, abnormal hemodynamics and vascular biomechanics are implicated. We used a novel animal model that facilitates quantification of CoA-induced hemodynamic and vascular biomechanics alterations and their impact on vascular structure and function, independent of genetic or confounding factors. Rabbits underwent thoracic CoA at 10 weeks of age (~9 human years) to induce a 20 mmHg blood pressure (BP) gradient using permanent or dissolvable suture thereby replicating untreated and corrected CoA. Computational fluid dynamics …

Soil Greenhouse Gas Emissions In The Life Cycle Assessment Of Cellulosic Ethanol From Crop Residue, Xiao Xue Fang

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Concerns about climate change and the increasing cost of fossil fuels have led to interest in the development of renewable biofuel pathways for reducing greenhouse gas (GHG) emissions. The use of corn residue as a potential source of biomass feedstock for cellulosic ethanol production has been favored as cost effective. Previous research has shown that crop residue removal can cause a loss of soil organic carbon (SOC), which potentially is a source of GHG emissions in the form of CO₂. Using a life cycle assessment (LCA) approach, this study investigated the impact of corn residue removal on total …

Aircraft Route Optimization For Heterogeneous Formation Flight, Jia Xu, Andrew Ning, Geoffrey Bower, Ilan Kroo

Faculty Publications

We examine the value of extended formation flight in the context of airline operations. The study is based on a bi-level route optimization framework. The aircraft performance model includes the effects of rolled-up wakes, formation heterogeneity, and formation-induced compressibility effects. We incorporate airline economics to understand the trade-off between speed and drag savings in the context of formation flight. The application of formation flight to a representative South African Airlines (SAA) long-haul route network can reduce fuel burn by over 4.6% or reduce direct operating cost by 2.1%. The savings increase to 6.8% in fuel or 2.4% in cost when …

Evaluation Of Hydraulic Conductivity Of Non Aqueous Phase Liquids In Partially Saturated Soils, Chijioke Ekeleme Akamiro

Civil & Environmental Engineering Theses & Dissertations

This study seeks to investigate a problem of predicting the hydraulic conductivity of NAPLs in partially saturated soils and to relate the hydraulic conductivity to basic soil parameters that are either easy to determine or are in wide use. To evaluate hydraulic conductivity in partially saturated soils, previous researchers have focused on flow geometry, soil and chemical properties, etc. used in CHEMFLO program by Nofziger et al., (1989) and saturation equations by such authors as Van Genutchen (1980) and Brooks and Corey (1964). Among those, the soil-water characteristic curve (SWCC) is the most widely used constitutive relations for unsaturated soils …

First Long-Term, Direct Measurements Of Evapotranspiration And Surface Water Balance In The Nebraska Sandhills, David P. Billesbach, Timothy J. Arkebauer

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The Nebraska SandHills is a vast grassland ecoregion that also serves as the main recharge zone for the High Plains (Ogallala) aquifer. Despite the national importance of this region in supplying irrigation water and supporting the US cattle industry, there have, until now, been no long-term, direct measurements of the components of the surface water balance. We have addressed this issue by installing energy balance/Bowen ratio (EBBR) flux towers in three key ecosystems. We report here the results of 7 years of measurements and interpret them in terms of annual weather variability. Additionally, these data have allowed us to make …

Evaluation Of The Bank Stability And Toe Erosion Model (Bstem) For Predicting Lateral Retreat On Composite Streambanks, Taber L. Midgley, Garey A. Fox, Derek M. Heeren

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Streambank erosion is known to be a major source of sediment in streams and rivers. The Bank Stability and Toe Erosion Model (BSTEM) was developed in order to predict streambank retreat due to both fluvial erosion and geotechnical failure. However, few, if any, model evaluations using long-term streambank retreat data have been performed. The objectives of this research were to (1) monitor long-term composite streambank retreat during a hydraulically active period on a rapidly migrating stream, (2) evaluate BSTEM’s ability to predict the measured streambank retreat, and (3) assess the importance of accurate geotechnical, fluvial erosion, and near-bank pore-water pressure …

Accounting For Indirect Land-Use Change In The Life Cycle Assessment Of Biofuel Supply Chains, Susan Tarka Sanchez, Jeremy Woods, Mark Akhurst, Matthew Brander, Michael O'Hare, Terence P. Dawson, Robert Edwards, Adam J. Liska, Rick Malpas

Adam Liska Papers

The expansion of land used for crop production causes variable direct and indirect greenhouse gas emissions; and other economic, social and environmental effects. We analyze the use of life cycle analysis (LCA) for estimating the carbon intensity of biofuel production from indirect land-use change (ILUC). Two approaches are critiqued; direct, attributional life cycle analysis (ALCA) and consequential life cycle analysis (CLCA). A proposed hybrid “combined model” of the two approaches for ILUC analysis relies on first defining the system boundary of the resulting full LCA. Choices are then made as to the modeling methodology (economic equilibrium or cause-effect), data inputs, …

The Development Of A Force Balance For Testing Micro Aerial Vehicles, Michael Christopher King

Doctoral Dissertations and Master's Theses

The purpose of this work was to create a six degree of freedom balance that could produce meaningful data for micro aerial vehicles. Research was conducted to investigate the common balance configurations, and the strengths and weaknesses of each configuration were used to select the most appropriate design. The limitations of available fabrication facilities, the desired level of performance and the end user of the balance were all considered to finalize the design. The balance and data acquisition system were fabricated over a period of several months, and unforeseen design issues were handled forthwith. Rigorous calibration and testing processes were …

Facility Implementation, Production, And Use Of Biodiesel On A University Campus, Michelle Erin Rodio

Doctoral Dissertations and Master's Theses

During the last two years, Embry-Riddle Aeronautical University has been in the process of having a fully-functional biodiesel processing facility on campus. Within this time, it was shown that biodiesel was a great alternative to diesel fuel based on emissions, performance, and cost, allowing for a grant of $10,000 being awarded to fund the project. Upon properly producing biodiesel, the fuel was tested in a John Deere 2653A tractor to see what differences, if any, existed when using a biodiesel blend over diesel fuel. In doing this, carbon buildup and fuel economy were compared, and a cost analysis conducted. It …

Evaluation Of Decellularization Procedures For Porcine Arteries, Charles Clapp

Biomedical Engineering

Coronary artery disease has become the leading cause of death in the United States, with over 425,000 deaths in 2006. Stenting has evolved into the preferred preventative technique for myocardial infarction by opening up an occluded artery, due to its low invasiveness compared to the alternative of coronary artery bypass grafting. Bare metal stents have been improved by coating with anti-proliferative drugs to advance their effects, but even drug eluting stents still have a risk of restenosis, thrombus formation, and necessary revascularization. Continual advancement in stent design necessitates faster, effective pre-clinical evaluation techniques. Kristen Cardinal, Ph.D., developed the blood vessel …

Development Of Best Management Practice Design Guidance For Roadway Applications In Nebraska, Benedict Vacha

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Runoff from roadways carries pollutants which may be detrimental to aquatic ecosystems. The primary pollutants of concern for roadway runoff are solids and heavy metals, particularly cadmium, copper, and zinc. Roadway runoff falls under the legislation of the Clean Water Act (CWA) via the National Pollutant Discharge Elimination System (NPDES). CWA regulates discharge of nonpoint source pollutants, such as roadway runoff, by issuing permits to public entities which manage Municipal Separate Storm Sewer Systems (MS4s). Part of the Nebraska Department of Roads (NDOR) permitting requirement is to create a design guide for Best Management Practices (BMPs) tailored to remediate roadway …

Spiking Neuron Computation With The Time Machine, Vaibhav Garg, Ravi Shekhar, John G. Harris

Electrical and Computer Engineering Faculty Research & Creative Works

The Time Machine (TM) is a spike-based computation architecture that represents synaptic weights in time. This choice of weight representation allows the use of virtual synapses, providing an excellent tradeoff in terms of flexibility, arbitrary weight connections and hardware usage compared to dedicated synapse architectures. The TM supports an arbitrary number of synapses and is limited only by the number of simultaneously active synapses to each neuron. SpikeSim, a behavioral hardware simulator for the architecture, is described along with example algorithms for edge detection and objection recognition. The TM can implement traditional spike-based processing as well as recently developed time …

Supercritical Co2 Extraction Of Oil From Henna Flower: Experimental, Mathematical Modeling, And Antioxidant Activity, Bushra Saeed Mohammed Dohai

Theses

Henna is a plant that has been used traditionally for coloring nail, skin, and hair, and as medicinal plant. The supercritical fluid technology offers a considerable promise as extraction media due to its advantages over other conventional extraction techniques. The extraction of volatile components from flowers of henna was studied using supercritical carbon dioxide at temperatures and pressures ranging from 35 to 55°C and 80 to 120 bar, respectively. A maximum extraction yield of 31 % from 2g of henna flowers was obtained at 45 °C and 120 bar. The composition of the extracts was investigated by gas chromatography technique. …

Detection And Analysis Of Sludge Bulking Events Using Data Mining And Machine Learning Approach, Yuanhao Zhao

Master's Theses (2009 -)

Sludge bulking is the most notable cause of activated sludge plant failure (i.e. exceeding discharge permit quality limits) worldwide. Numerous mathematical methods have been applied to detect and provide warning for the prevention of sludge bulking. However, these models often fail to reliably forecast sludge bulking events because they focus on the point-by-point "curve-fitting" strategy, while the number of bulking event data points is relatively small in comparison with the large amount of data in the time series. Therefore, three machine learning approaches which focus on detecting the temporal pattern data before the sludge bulking events are considered in this …

An Efficient Boosted Classifier Tree-Based Feature Point Tracking System For Facial Expression Analysis, Adam Redd Livingston

Electrical & Computer Engineering Theses & Dissertations

The study of facial movement and expression has been a prominent area of research since the early work of Charles Darwin. The Facial Action Coding System (FACS), developed by Paul Ekman, introduced the first universal method of coding and measuring facial movement. Human-Computer Interaction seeks to make human interaction with computer systems more effective, easier, safer, and more seamless. Facial expression recognition can be broken down into three distinctive subsections: Facial Feature Localization, Facial Action Recognition, and Facial Expression Classification. The first and most important stage in any facial expression analysis system is the localization of key facial features. Localization …

Optimization Framework For A Radio Frequency Gun Based Injector, Alicia S. Hofler

Electrical & Computer Engineering Theses & Dissertations

Linear accelerator based light sources are used to produce coherent x-ray beams with unprecedented peak intensity. In these devices, the key parameters of the photon beam such as brilliance and coherence are directly dependent on the electron beam parameters. This leads to stringent beam quality requirements for the electron beam source. Radio frequency (RF) guns are used in such light sources since they accelerate electrons to relativistic energies over a very short distance, thus minimizing the beam quality degradation due to space charge effects within the particle bunch. Designing such sources including optimization of its beam parameters is a complex …

Creation Of Large Scale Face Dataset Using Single Training Image, Qun Wang

Electrical & Computer Engineering Theses & Dissertations

Face recognition (FR) has become one of the most successful applications of image analysis and understanding in computer vision. The learning-based model in FR is considered as one of the most favorable problem-solving methods to this issue, which leads to the requirement of large training data sets in order to achieve higher recognition accuracy. However, the availability of only a limited number of face images for training a FR system is always a common problem in practical applications. A new framework to create a face database from a single input image for training purposes is proposed in this dissertation research. …

Synergistic Effect Of Subnanosecond Pulsed Electric Fields And Temperature On The Viability Of Biological Cells, James Thomas Camp

Electrical & Computer Engineering Theses & Dissertations

Pulsed electric fields have been used to induce a biological response in cells, and at sufficient energy, can cause cell death. By reducing the pulse duration from presently used nanosecond to subnanosecond ranges, the electric field can be delivered to biological tissue non-invasively by the use of an antenna instead of electrodes, such as needles. Studies have previously been completed in which the aim was to determine the energy density (electric field strength, number of pulses) required to induce cell death with 800 ps pulses. Based on this data, it was concluded that for pulse durations of 200 ps, with …

Health Nexus: A Serious Game Prototype For Prevention And Treatment Of Obesity And Diabetes, Joseph C. Miller

Computational Modeling & Simulation Engineering Theses & Dissertations

Electronic games are a prevalent phenomenon of American culture and entertainment. Serious games are video games that take advantage of games' intrinsic entertaining and challenging characteristics for serious purposes, such as education, training, advertisement, and political campaigns. A significant number of serious games have been developed for a variety of diverse purposes. The last few years have witnessed the inception and growth of motion sensing technologies for games, including Nintendo Wii, Sony PlayStation Move, and Microsoft Kinect. These motion sensing technologies usually require game players' physical body movement in order to perform and achieve in the games, such as playing …

Electrokinetic Transport Phenomena In Nanofluidic Devices, Mingkan Zhang

Mechanical & Aerospace Engineering Theses & Dissertations

Nanofluidic devices have wide potential applications in biology, chemistry and medicine, and have been proven to be very valuable in sensing biological particles (e.g., DNA and proteins) due to their efficiency, sensitivity and portability. Electrokinetic control of ion, fluid, and particle transport by using only electric field is the most popular method employed in nanofluidic devices. A comprehensive understanding of the electrokinetic ion, fluid, and particle transport in nanofluidics is essential for developing nanofluidic devices for the detection of single molecules, such as the next generation nanopore-based DNA sequencing technology. This research explored numerical simulation of electrokinetic ion and fluid …

Image-Guided Robotic Dental Implantation With Natural-Root-Formed Implants, Xiaoyan Sun

Electrical & Computer Engineering Theses & Dissertations

Dental implantation is now recognized as the standard of the care for tooth replacement. Although many studies show high short term survival rates greater than 95%, long term studies (> 5 years) have shown success rates as low as 41.9%. Reasons affecting the long term success rates might include surgical factors such as limited accuracy of implant placement, lack of spacing controls, and overheating during the placement.

In this dissertation, a comprehensive solution for improving the outcome of current dental implantation is presented, which includes computer-aided preoperative planning for better visualization of patient-specific information and automated robotic site-preparation for superior …

Nonosecond Pulsed Electric Field Induced Changes In Dielectric Properties Of Biological Cells, Jie Zhuang

Electrical & Computer Engineering Theses & Dissertations

Nanosecond pulsed electric field induced biological effects have been a focus of research interests since the new millennium. Promising biomedical applications, e.g. tumor treatment and wound healing, are emerging based on this principle. Although the exact mechanisms behind the nanosecond pulse-cell interactions are not completely understood yet, it is generally believed that charging along the cell membranes (including intracellular membranes) and formation of membrane pores trigger subsequent biological responses, and the number and quality of pores are responsible for the cell fate. The immediate charging response of a biological cell to a nanosecond pulsed electric field exposure relies on the …