Digital Commons Network^™

Formulation And Stability Of A Chikungunya Virus-Like Particle (Chikv Vlp) Based Vaccine, Rhicard Schwartz

Vaccine Technology IV

No abstract provided.

Rift Valley Fever: Next Generation Vaccines For An Old Foe, Brian Bird

Vaccine Technology IV

No abstract provided.

Leishmaniasis Vaccine Development: Animals As Models And Patients, Steven Reid

Vaccine Technology IV

No abstract provided.

Conference Program, Engineering Conferences International

Vaccine Technology IV

No abstract provided.

Tolerogenic Vaccination Exploiting Apoptotic Mechanisms Via Erythrocyte-To- Hepatic/Splenic Targeting, Jeffrey Hubbell

Vaccine Technology IV

No abstract provided.

Bringing Vaccine Manufacturing Capabilities To The Developing World, George Robertson

Vaccine Technology IV

No abstract provided.

Cloning And Characterization Of Sas0754, A Hypothetical Protein From Community Associated Staphylococcus Aureus, Unknown Unknown

Symposium 2012

Community associated Staphylococcus aureus (strain MSSA476) is a gram positive cocci capable of infecting many different parts of the body and known to cause serious infections that can be fatal, such as bacterial arthritis and acute endocarditis. To find effective ways of fighting against CA-MRSA strains we must learn more about their ability to infect. The focus of this study was cloning and characterization of a protein referred to as SAS0754. The size of SAS0754 is 340 amino acids and the gene sequence is 1023 nucleotides. The hypothetical function of this protein is that it is an extracellular matrix binding …

Rabies Virus-Like Particles Expressed In Hek293 Cells, Diego Fontana, Ricardo Kratje, Marina Etcheverrigaray, Claudio Prieto

Vaccine Technology IV

No abstract provided.

Expectation Of China's Contribution To World Vaccine Development And Supplies: Status, Strategy And International Approach, Li Shi

Vaccine Technology IV

No abstract provided.

A Convenient Synthesis Of 2,6-Dichlorohomonicotinic Acid, Chase Buchanan, Richard W. Fitch

Symposium 2012

In our synthetic efforts toward the alkaloid phantasmidine, we required a convenient source of the title compound. Herein, we describe a short synthesis of 2,6-dichlorohomonicotinic acid by direct allylation of 2,6-dichloropyridine with LDA/allyl chloride, followed by permanganate oxidation of the side chain [figure1]. Yields for the allylation are high, while permanganate oxidation required more adjustment. Successful conditions require the modest acidification of the mixture with acetic acid and cleanup by acid base workup. No chromatography is needed.

Convenient Parallel Synthesis Of Alkyl- And Aryl-S-Tert-Butyl Thiothers, Rebecca Norcross, Jessica Stanfield, Richard W. Fitch

Symposium 2012

While preparing novel cysteine derivatives as oxidation catalysts, we needed S-tert-butylcysteine. We also examined acid-promoted tert-butylation of thiols using tert-butanol as reagent and solvent. While cysteine and aminoethanethiol work well using tBuOH in 4M HCl, other thiols fail in the aqueous environment and aerobic conditions. We examined a variety of aliphatic and aromatic thiols in tBuOH with H2SO4 catalysis and found that argon sparging and the use of 1 eq of acid led to good yields in a parallel format.

Process Understanding Approach For A Late-Stage Recombinant Protein Vaccine Produced In Saccharomyces Cerevisiae, Jose Manuel Otero, Brian Mickus, Amanda Schallop, Brian Doyle, Nedim Altaras

Vaccine Technology IV

No abstract provided.

Challenges In Development Of An Anti-Idiotypic Cancer Vaccine, Adolfo Castillo

Vaccine Technology IV

No abstract provided.

The Role Of Public-Private Partnerships In Advancing Vaccine Technologies And Improving Vaccine Effectiveness And Delivery For Developing Countries, Ray Cummings

Vaccine Technology IV

No abstract provided.

Challenges In Batch Production Of Malaria Vaccines, Nicolas Havelange

Vaccine Technology IV

No abstract provided.

Establishing Human Vaccine Manufacturing In Southern Africa, Morena Makhoana

Vaccine Technology IV

No abstract provided.

Rational Design Of A Fully Synthetic Nanoparticle-Based Vaccine For Smoking Cessatio, Takashi Kishimoto

Vaccine Technology IV

No abstract provided.

Recombinant Vlp Based Human Vaccines For Emerging Markets, Qinjian Zhao

Vaccine Technology IV

No abstract provided.

111 Years Producing Immunobiologicals: New Challenges, Jorge Kalil

Vaccine Technology IV

No abstract provided.

Development Of A Vaccine Against Clostridium Difficile Infection (Cdi): Design, Purification, And Biological Activities Of The Recombinant Toxin 1 Antigens, Jerzy Karczewski

Vaccine Technology IV

No abstract provided.

Recombinant Influenza Vaccine, Manon Cox

Vaccine Technology IV

No abstract provided.

Glasses For Radiotherapy, Delbert E. Day

Materials Science and Engineering Faculty Research & Creative Works

No abstract provided.

Active Response Of Polymer Materials From External Stimuli – Solvents And Light; Grafting Reactions On Perovskite Layers, Jianxia Zhang

LSU New Orleans Theses and Dissertations

The active response of a series of polymeric materials was investigated. Both solvent activated and light activated thin films and wire systems show dynamic behaviors when exposed to different stimuli.

Solvent mediated fluxional behavior of polymer thin films involved extensive, rapid curling both on infusion and evaporation of good solvents. These films can be either lab-fabricated ones or commercial ones, and the curling behavior can be as fast as seconds. Conditions including polymer materials, chosen solvents, and film geometry can affect the behavior.

Methods that allowed for the creation and retention of distorted wire structures were also developed; the asymmetric …

Pattern Recognition Of Power System Voltage Stability Using Statistical And Algorithmic Methods, Varun Togiti

LSU New Orleans Theses and Dissertations

In recent years, power demands around the world and particularly in North America increased rapidly due to increase in customer’s demand, while the development in transmission system is rather slow. This stresses the present transmission system and voltage stability becomes an important issue in this regard. Pattern recognition in conjunction with voltage stability analysis could be an effective tool to solve this problem

In this thesis, a methodology to detect the voltage stability ahead of time is presented. Dynamic simulation software PSS/E is used to simulate voltage stable and unstable cases, these cases are used to train and test the …

A Pressure Gauge Based On Gas Density Measurement From Analysis Of The Thermal Noise Of An Atomic Force Microscope Cantilever, Dongjin Seo, Mark R. Paul, Willian A. Ducker

Faculty Publications

We describe a gas-density gauge based on the analysis of the thermally-driven fluctuations of an atomic force microscope (AFM) cantilever. The fluctuations are modeled as a ring-down of a simple harmonic oscillator, which allows fitting of the resonance frequency and damping of the cantilever, which in turn yields the gas density. The pressure is obtained from the density using the known equation of state. In the range 10–220 kPa, the pressure readings from the cantilever gauge deviate by an average of only about 5% from pressure readings on a commercial gauge. The theoretical description we use to determine the pressure …

Application Of Intelligent-Objects Simulation To Manufacturing Process Efficiency Analysis: A Case Study, Justin Hamilton

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science by Justin Hamilton on May 12, 2012.

Computational Design And Characterization Of A Temperature-Sensitive Plasmid Replicon For Gram Positive Thermophiles, Daniel G. Olson, Lee R. Lynd

Dartmouth Scholarship

Temperature-sensitive (Ts) plasmids are useful tools for genetic engineering, but there are currently none compatible with the gram positive, thermophilic, obligate anaerobe, Clostridium thermocellum. Traditional mutagenesis techniques yield Ts mutants at a low frequency, and therefore requires the development of high-throughput screening protocols, which are also not available for this organism. Recently there has been progress in the development of computer algorithms which can predict Ts mutations. Most plasmids currently used for genetic modification of C. thermocellum are based on the replicon of plasmid pNW33N, which replicates using the RepB replication protein. To address this problem, we set out …

Optimization Of Feature Selection In A Brain-Computer Interface Switch Based On Event-Related Desynchronization And Synchronization Detected By Eeg, Mason Montgomery

Theses and Dissertations

There are hundreds of thousands of people who could benefit from a Brain-Computer Interface. However, not all are willing to undergo surgery, so an EEG is the prime candidate for use as a BCI. The features of Event-Related Desynchronization and Synchronization could be used for a switch and have been in the past. A new method of feature selection was proposed to optimize classification of active motor movement vs a non-active idle state. The previous method had pre-selected which frequency and electrode to use as electrode C3 at the 20Hz bin. The new method used SPSS statistical software to determine …

Biomedical Matching Gui Development, Nazia Sarang

Electrical and Computer Engineering Graduate Theses and Dissertations

Biomedical researchers constantly search for new methods to diagnose the extent of joint injuries in live human subjects. In order to achieve this, the researchers need to know the accurate three dimensional kinematic data of bones and joints and to accurately quantify how bones in a joint move relative to one another during dynamic activities. Algorithms have been developed previously to estimate the exact spatial position and movement of the bones. These methods involved generation of digitally reconstructed radiographs (DRR) from a three dimensional CT scan image of human joint with known position and orientation and comparing it with the …

Characterization Of Superhydrophobic Surfaces Fabricated Using Ac-Electrospinning And Random Particle Deposition, Mohamed Samaha Jr.

Theses and Dissertations

Surfaces with static contact angle greater than 150 degrees are typically classified as superhydrophobic. Such coatings have been inspired by the lotus leaf. As water flows over a superhydrophobic surface, "slip effect" is produced resulting in a reduction in the skin-friction drag exerted on the surface. Slip flow is caused by the entrapment of a layer of air between water and the surface. Superhydrophobicity could be utilized to design surfaces for applications such as energy conservation, noise reduction, laminar-to-turbulent-transition delay, and mixing enhancement. A popular method of manufacturing a superhydrophobic surface is microfabrication in which well-designed microgrooves and/or poles are …