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An Advanced Hexacopter For Autonomous Exploration Of Mars: Attitude Control And Navigation Strategies, Laura Sopegno

Electronic Theses and Dissertations

Mars exploration has recently witnessed major interest within the scientific community. Unmanned robotic platforms offer reliable solutions to acquire and collect data and information from the Red Planet. Particularly, rovers, landers, and orbiters have significantly shaped planetary exploration on the Moon and Mars, contributing significantly to past missions while also highlighting limitations in their capacity to cover diverse terrains over wide ranges. Given current advances in Unmanned Aircraft Systems (UASs), Unmanned Aerial Vehicles (UAVs) offer promising alternatives for future scientific missions.

It is argued that hexacopters, with their relatively compact design and redundancy, present a promising …

Reducing Attention Complexity In Graph Transformers Through Subgraph Partitioning, Ranjan Kumar Choubey

Master’s Dissertations

This dissertation addresses the challenge of scaling Graph Transformers by proposing a subgraph-based strategy to reduce attention complexity. The proposed framework preserves representational power while making attention computation tractable for largescale graphs. The method begins by partitioning the input graph into K subgraphs using the METIS algorithm. Each subgraph is encoded using a combination of local structural features from a Graph Convolutional Network (GCN) and global positional cues from Laplacian Positional Embeddings (LPEs). These embeddings are fused via a trainable projection function to form subgraph tokens. A supergraph is constructed to model interactions among subgraphs, allowing attention to be applied …

Piloted Autonomous Crisis Reconnaissance Robot 2.0 (Pacrr 2.0), Awawu Alimi, Urmika Ghosh, Marissa Kuo, Jonathan Santosa, Ethan Wyrick

Electrical and Computer Engineering Senior Theses

PACRR 2.0 (Piloted Autonomous Crisis Reconnaissance Robot, version 2) builds upon the original low-cost, autonomous-capable quadruped platform by enhancing both mobility and environmental perception for first-responder applications such as search and rescue, gas leak detection, and mapping of confined or hazardous areas. In PACRR 2.0, we integrate an RGB-D camera with analytic inverse kinematics and frame-based motion planning to achieve precise foot placement and stable quasi-static gaits even on sloped or uneven terrain. An NVIDIA Jetson processor runs high-level control and mapping alongside a Raspberry Pi 4 to manage motor control. Through simulation, we demonstrate robust 3D map generation and …

Tunable Methacrylated Decellularized Heart Matrix: A Versatile Scaffold For Cardiac Tissue Engineering, Valinteshley Pierre, Douglas H. Wu, Chao Liu, Elif Ertugral, Chandrasekhar R. Kothapalli, Samuel E. Senyo

Chemical & Biomedical Engineering Faculty Publications

Therapeutic tissue regeneration remains a significant unmet need in heart failure and cardiovascular disease treatment, which are among the leading causes of death globally. Decellularized heart matrix (DHM) offer promising advantages for tissue engineering, including low immunogenicity and seamless integration into biological processes, facilitating biocompatibility. However, DHM is challenged by weak mechanical properties that limit its utility to biomedical applications like tissue engineering. To address this limitation, we functionalized DHM with methacryloyl functional groups (DHMMA) that support UV-induced crosslinking to enhance mechanical properties. By modulating the degree of methacryloyl substitution, a broad range of stiffness was achieved while maintaining cell …

Evolutionary Influences On Oceanic Islands Parasites: Phylogeography, Genetic Structure, And The “Island Rule” Of Common Ground Doves (Columbina Passerina) And Their Lice, Paige Jordan Brewer

Student Theses and Dissertations

Organisms on oceanic island archipelagos often exhibit strong genetic signatures and adaptations. Here, we focus on Common Ground Doves (Columbina passerina) and their parasitic lice, Physconelloides body lice and Columbicola wing lice, across the Caribbean islands to examine phylogeography, population genetics, and the “Island rule”. We used genome-wide sequences and found C. passerina doves and their lice exhibited unique dispersal patterns and phylogenetic relationships; however, similar population structure. We also found distinct patterns of genetic diversity between Physconelloides and Columbicola, likely caused by variations in their dispersal abilities. Additionally, we measured C. passerina specimens and their lice to compare island …

Topological Indices For The Resize Graph Of (G2(3)), Manar Musab Ftekhan, Ali Abd Aubad

Iraqi Journal for Computer Science and Mathematics

Indexes of topological play a crucial role in mathematical chemistry and network theory, providing valuable insights into the structural properties of graphs. In this study, we investigate the Resize graph of G₂(3), a significant algebraic structure arising from the exceptional Lie group (G₂) over the finite field F₃. We compute several well-known topological indices, including the Zagreb indices, Wiener index, and Randić index, to analyze the graph's connectivity and complexity. Our results reveal intricate relationships between the algebraic structure of G₂(3) and its graphical properties, offering a deeper understanding of its combinatorial …

Highly Adaptable Dendrimer Gel Nanoparticles With Dual Targeting Of Upar And Ribonucleotide Reductase R2 For Better Retention And Improved Therapeutic Outcomes In Triple-Negative Breast Cancer, Hsin Yin Chuang, Da Huang, Lin Qi, Vidit Singh, Anna Chernatynskaya, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) accounts for approximately 15% of breast cancers and lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to hormonal or anti-HER2 therapies. Due to its poor prognosis and limited treatment options, there is an urgent need for targeted therapies. In this study, we developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2). These nanoparticles were designed to target both TNBC cells and cancer-associated stromal cells by leveraging uPA-uPAR interactions and delivering the antisense oligonucleotide …

Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li

Faculty Publications

Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …

Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown

Theses and Dissertations

This thesis presents a novel approach for modeling and simulating tensegrity structures with continuous cables. A Python-based simulation framework package was developed to address limitations in existing tensegrity modeling software, particularly the inability to model cables passing through multiple nodes. The framework utilizes virtual work methods to solve for equilibrium configurations of 2D, 2.5D and 3D tensegrity systems. Key features include: • A YAML-based input system for easy definition of tensegrity topologies. • Algorithms for handling continuous cables spanning multiple nodes. • Optimization techniques to find stable equilibrium states. • Capability to simulate 2.5D structures wrapped around cylindrical surfaces. • …

Emg Vocal Translations, Lucas Amlicke, Raphael Kusuma, Cole Heider, Kayleigh Vu, Monica Sommer

Electrical and Computer Engineering Senior Theses

In this paper, we propose a novel augmentative and alternative communication (AAC) framework for silent speech. Many individuals with speech impairments are unable to vocalize effectively due to various conditions that affect the vocal cords. To engage in social activities, many rely on AAC devices that often lack flexibility and expressiveness. Users may still find self-expression and spontaneity difficult with such devices. This project presents a novel approach to developing a silent speech interface (SSI), providing a more adaptable and user-centered solution to give the vocally impaired a voice. Using surface electromyography (sEMG) alongside machine learning techniques, we aim to …

Selective Anti-Tumor And Normal Tissue Sparing Effects Of Flash Radiotherapy In A Simple Algebraic Model Of Radiochemical Kinetics, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Background: This short paper presents the solution to an open problem in medical physics: how and when FLASH radiotherapy can have a selective anti-tumor effect. FLASH radiotherapy gives a single large dose of ionizing radiation to a cancer patient within a time span of a few milliseconds, unlike conventional radiotherapy which is divided into several dose fractions given weekly, each lasting about 10 minutes. In some animal models FLASH seems to improve tumor cell killing without damaging normal tissues. However, the mechanism of the selective anti-tumor effect remains elusive. Methods: To explore effects of tissue hypoxia in tumors, a model …

Simulation Of Multi-Receiver Solar Power Tower By Enhancement Of Solarpilot Software And A Review Of Absorber Coating Materials For The Receivers, Yasser Mirza Baig

USF Tampa Graduate Theses and Dissertations

Central receiver concentrating solar power (CSP) towers offer significant potential for cost-effective renewable electricity but face increasing optical losses with larger heliostat fields. This thesis introduces enhancements to NREL’s SolarPILOT software through a Python-based API named CoPylot, which enables comprehensive optimization of heliostat field layouts for multi-receiver systems. The enhanced methodology incorporates per-heliostat ray tracing, receiver orientation optimization (tilt angle β), and an incidence-angle-dependent absorptance (α(θ)) model to evaluate optical performance, thermal losses, and techno-economic metrics within an integrated simulation framework.

A case study for Daggett, California demonstrates that transitioning from a baseline single-receiver system (180 m tower, 5×5 m …

A Versatile Platform For Designing And Fabricating Multi-Material Perfusable 3d Microvasculatures, Nathaniel Harris, Charles Miller, Min Zou

Mechanical Engineering Faculty Publications and Presentations

Perfusable microvasculature is critical for advancing in vitro tissue models, particularly for neural applications where limited diffusion impairs organoid growth and fails to replicate neurovascular function. This study presents a versatile fabrication platform that integrates mesh-driven design, two-photon lithography (TPL), and modular interfacing to create multi-material, perfusable 3D microvasculatures. Various 2D and 3D capillary paths were test-printed using both polygonal and lattice support strategies. A double-layered capillary scaffold based on the Hilbert curve was used for comparative materials testing. Methods for printing rigid (OrmoComp), moderately stiff hydrogel (polyethylene glycol diacrylate, PEGDA 700), and soft elastomeric (photocurable polydimethylsiloxane, PDMS) materials were …

Orchestrating Complexity: The Art Of Virtual Leadership In System Modelling, Vijay Kumar Sonawane, Bipllab Roy, Purnendu Bikash Acharjee, Indu Pv

Northeast Journal of Complex Systems (NEJCS)

This paper explores the dynamics of virtual leadership within global remote work environments, focusing on the application of complex system modelling to understand and enhance leadership efficacy. The application of computational modelling has been a regular feature in economics, science and technology fields, however its application in virtual leadership with linkage to sport leadership appears to be a novel concept. Adopting a multidisciplinary approach, this paper incorporates Game Theory as a conceptual framework to make the leadership model more relevant and applicable that can offer simpler understanding of complex play of leadership drivers. The model incorporates five key leadership dimensional …

Continuous Monitoring Of Dynamic Levels Of Sepsis-Associated Biomarkers In Blood For Early Diagnosis, Aidan Burke, Jake Chansky, Anders Kouhia, Brian Mostofi

Bioengineering Senior Theses

Sepsis is a general diagnosis related to a dysregulated immune response to a source of infection that, if left untreated, will most likely result in organ failure and eventual death. Sepsis affects 49 million people annually, and is responsible for 11 million annual deaths, according to Jarczak 1. A recent study has shown that over 80% of sepsis deaths may be preventable with earlier diagnosis and treatment, and that the risk of mortality increases by 8% for every hour that sepsis goes untreated 5. Thus, our team identified that the timeliness of sepsis diagnosis is a paramount healthcare need.

We …

The Engineering Mindset: Blueprint For Change, Vol. 1: Institutional Guidelines For Implementing Change In Undergraduate Engineering And Engineering Technology Education, Rebecca Bates, Ron Ulseth

Integrated Engineering Department Publications

Volume 1 of the Blueprint Report presents a comprehensive framework for transforming undergraduate engineering and engineering technology education in the United States. It builds on the 2024 Engineering Mindset Report and provides institutional-level strategies to implement its recommendations. The goal is to create a student-centered curriculum, increase access and success for underserved students, and create a future-ready engineering education system that broadens access and aligns with societal and technological needs.

Tellings Of The Pacific Ocean: A Landscape-Based Approach For Multispecies Design And Hci, Maliheh Ghajargar

Engineering Faculty Articles and Research

Environmental disturbances induced by climate change have caused significant changes in our ecosystems and are threatening the health of our environments. As a response to this issue, a growing body of work has emerged in HCI and design, which seeks to foreground more-than-human stories in support of making more sustainable and just futures. This research contributes to this broad agenda by probing graphic novels as a multispecies storytelling method for design and HCI. Combining ideas from Anna Tsing’s adventures of landscape and from HCI and design’s use of sequential art (e.g., storyboards), we use landscape as the main protagonist of …

A Hybrid Ai-Based Framework For Real-Time Epileptic Seizure Detection In Intracranial Eeg Signals Using Brain-Computer Interfaces, Ahmed, M. Salaheldin Dr., Manal Abdel Wahed Prof., Neven Saleh

Future Engineering Journal

Epilepsy is a serious neurological disorder that can significantly impact an individual's quality of life. This study proposes a novel method for the detection and mitigation of epileptic seizures through the integration of artificial intelligence (AI) and a brain-computer interface (BCI) system. Statistical features were extracted from intracranial electroencephalography (IEEG) signals using a multi-resolution decomposition technique and used to train five classification algorithms: support vector machines (SVM), k-nearest neighbors (KNN), Naïve Bayes (NB), artificial neural networks (ANN), and long short-term memory (LSTM). The model demonstrated strong performance, achieving classification accuracies of 98.28% (SVM), 93.88% (KNN), 95.73% (NB), 95.73% (ANN), and …

Centralized, Decentralized And Hybrid Wastewater Management Approaches – Gap Study, Zeyad Kadry, Ahmed M. Ebid Dr., Ibrahim Mahdi

Future Engineering Journal

This literature review highlights advancements in wastewater management, emphasizing hybrid systems that integrate centralized and decentralized approaches. It underscores the cost-effectiveness and scalability of decentralized wastewater management (DWWM) for small urban and rural areas, despite higher land and capital needs. Optimization frameworks utilizing advanced computational tools, such as genetic algorithms and GIS, have proven effective in reducing costs and enhancing resource recovery, with decision-support frameworks tailored for rural planning. The integration of synergistic technologies like vertical farming and photovoltaic energy enhances the sustainability and resilience of decentralized systems in urban contexts. Additionally, innovative treatment methods, including nano-disinfection and advanced coagulation, …

Eliminating Assay Background Of A Low-Cost, Colorimetric Glutamine Biosensor By Engineering An Alternative Formulation Of Cell-Free Protein Synthesis, Joseph P. Talley, Tyler J. Free, Tyler P. Green, Dallin M. Chipman, Bradley Charles Bundy

Faculty Publications

Glutamine is an essential biomolecule that plays a pivotal role in many diseases, such as cancer, where it can serve as fuel for rapid proliferation. Treatments for these diseases can be monitored and optimized through the detection of glutamine, though standard glutamine detection procedures are costly and require complex instrumentation. Cell-free protein synthesis (CFPS) has recently enabled a paper-based, colorimetric glutamine sensor that carries the potential to increase test accessibility while dramatically reducing consumer cost to enable at-home, rapid treatment monitoring. Test sensitivity remained limited by residual assay background, thus motivating this work where CFPS reactions traditionally formulated with glutamate …

Atp8b1 Regulates Pip2 Localization And Cleavage Of Pyroptotic Executioner Gasdermin D, Nilam Bhandari, Ashutosh Prince, Mariam R. Khan, Alicia Traughbera, Kalash Neupane, Shuhui W. Lorkowski, Gregory Brubaker, Elif G. Ertugral, Chandrasekhar R. Kothapalli

Chemical & Biomedical Engineering Faculty Publications

Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection between ATP8B1 and phosphoinositide (PIPs), but the mechanism linking ATP8B1, lipid metabolism, and inflammation remains unclear. Atp8b1G308V/G308V mouse model, unbiased RNAseq, high-resolution-stimulation emission depltion (STED)-microscopy, and Crispr-Cas9 generated ATP8B1-/- knockouts in hepatocytes/monocytes/macrophages were used to determine role of ATP8B1 in phosphatidylinositol,4-5-bisphosphate (PIP2) trafficking and inflammation. Human ATP8B1, purified from Sf9 insect cells and reconstituted in proteoliposomes, was used to test cell-free PIP2 flip. Various in-vitro techniques were used for testing direct interaction between PIP2 and …

Novel Electrospinning Techniques For Fabricating Scaffolds To Model Intracranial Atherosclerotic Disease In Tissue Engineered Blood Vessel Mimics, Isaac "Squeaky" Buentipo

Master's Theses

Novel Electrospinning Techniques for Fabricating Scaffolds to Model Intracranial

Atherosclerotic Disease in Tissue Engineered Blood Vessel Mimics

Isaac “Squeaky” Buentipo

Dr. Kristen Cardinal’s Tissue Engineering Lab at California Polytechnic State University specializes in fabricating customized vascular models, known as Blood Vessel Mimics (BVMs), for medical device testing. BVMs are simplified in vitro vascular models designed to bridge the gap between bench testing and in vivo evaluation of intravascular medical devices. BVMs are produced by combining a polymer scaffold with human vascular cells. Through novel scaffold fabrication techniques, such as silicone injection molding, silicone dip casting and electrospinning, the capabilities of …

Evaluation Of Antibiotic Testing Protocols For Biofilm-Forming Escherichia Coli In A Microfluidic Platform, Caleb R. Telander

Master's Theses

Catheter-associated urinary tract infections remain an ongoing clinical problem due to biofilm persistence and antibiotic resistance. Standard antibiotic susceptibility testing cannot accurately reproduce flow conditions and the spatial complexity of the in vivoenvironment and is thus questionable in relevance to device-related infections. This study examines a microfluidic device designed to simulate physiologically relevant wall shear stress and antibiotic gradients in Escherichia coli biofilms. The polydimethylsiloxane-based system integrates a 16-well culture chamber with a gradient generator. Biofilm growth was observed using fluorescence microscopy of green fluorescent protein-labeled bacteria. Simulations performed using COMSOL Multiphysics software estimated the appropriate range of wall …

Opensim Analysis Of The Aymara Indigenous People Performing Ancestral Tasks: Exploring Trends Of Muscle Activity With Tiwanaku Skeletal Indicators, Noah M. Taylor

Master's Theses

The Tiwanaku civilization (AD 500-1100) of the Andean highlands exhibited occupational specialization in communities, with archeological evidence suggesting the existence of labor- and residential-communities, or “taskscapes”, based on an individual’s livelihood. Prior bioarcheological studies have examined Tiwanaku skeletal remains for musculoskeletal stress markers, osteoarthritis, and cross-sectional geometry to infer activity patterns. Their descendants, the Aymara Indigenous people, currently live in the same highlands and until recently lived a lifestyle like their ancestors. Over the past 20 years, the global quinoa demand has risen, thrusting the Aymara into globalization and moving them away from the traditional tasks previously performed. This study …

Acoustic And Hemodynamic Analysis Of Phantoms: Roughness And Flow Dynamics, Ethan Erik Olof Sundberg

Master's Theses

The purpose of this study was to determine whether different vascular phantoms, with and without a surrogate arm, could serve as effective analogs to the human brachial artery for assessing endothelial dysfunction, an early indicator of cardiovascular disease, particularly atherosclerosis. Atherosclerosis is characterized by plaque buildup and endothelial damage, which precede more severe clinical events and are often detectable through changes in vascular function. A 40” water tower was used to simulate diastolic pressure, enabling water flow through each phantom. Strain gauge pressure transducers were placed at both ends of the phantoms to measure pressure drop, while a microphone captured …

A Manufacturing Process For Interdigitated Microelectrodes On Glass Wafers, Wyatt W. Warfield

Master's Theses

This study presents work done to optimize the process parameters to produce interdigitated electrodes on a borosilicate wafer. Using designed experiments and statistical analysis, the error in pattern transfer was minimized using for key process steps including exposure time, develop time and post exposure bake duration. Similarly, statistical analysis was used with profilometry data to fine tune the develop times. Qualitative analysis was used to assess thin film deposition. The resulting process produced wafers with improved pattern transfer and adequate film adhesion

Optimizing Microfluidic Murine Fibroblast And Human Epidermal Keratinocyte Cell Culture In 70Μm Microwells, Christian Navarro

Master's Theses

Cell culture is an essential technique utilized in biotechnology and medicine to remove systemic influences to study cellular behavior and morphological development of individual cell lines. However, conventional cell culture is two-dimensional and static meaning it can’t easily mimic in vivo conditions such as multicellular cell to cell interactions, fluid perfusion, or 3D structures which might alter cellular behavior and morphology. Microfluidic cell culture allows for the incorporation of in vivo conditions such as perfusion and chemical gradients allowing for more physiologically accurate models. The goal of this study is to develop a protocol for testing a microfluidic chip designed …

Ambulatory Monitoring Of Biomarkers For Enhanced Recovery, Guneet Grewal, Grace Kurilo, Maggie Nostrand, Vismaya Panicker

Bioengineering Senior Theses

The objective of our project is to create, design and test a fully functional continuously monitoring hydrogen peroxide sensor. This sensor aims to identify early detection of diseases associated with oxidative stress which can include certain types of cancer, neurodivergent diseases and cardiovascular diseases. Early detection of hydrogen peroxide levels can provide patients with early treatment and can help reduce disease progression. Overall, the biosensor prioritizes early detection of ROS levels allowing various consumers such as healthcare sectors, patients, and research institutions to benefit from continuous monitoring for health management and disease prevention.

Experimental Evaluation Of Novel Nano Polymer Hybrid Enhanced Oil Recovery In Carbonate Reservoir, Altamish Ahmed Pakeer

Theses

Innovative enhanced oil recovery (EOR) strategies are needed to unlock additional reserves in heterogeneous, oil-wet carbonate reservoirs. This study evaluates hybrid nano-polymer flooding by integrating silica nanoparticles (SiO₂) and single-walled carbon nanotubes (CNT) with novel HPAM polymers (Sav10 and Sav10 VHM) to optimize wettability alteration, rheological parameters, and recovery mechanisms.

A comprehensive experimental approach was employed, where rheological tests assessed viscosity enhancement under varying shear conditions, and wettability alteration was quantified via contact angle measurements using HPAM-SiO₂, HPAM-CNT, Sav10 VHM-SiO₂, and Sav10 VHM-CNT systems. Core floods were performed in three consecutive phases; waterflooding (baseline), standalone nanoparticle flooding, and hybrid nano-polymer …

Electroporation Protocol Development For Cal Poly Cell Therapy Laboratory Courses, Gabrielle Melamed

Biomedical Engineering

Cancer is a heterogeneous disease caused by unchecked cell proliferation. The disease contributed to 9.7 million deaths worldwide in 2022, with hematological malignancies (leukemias, lymphomas, and myelomas) accounting for over 1.4 million deaths in the United States from 1999 to 2020. This thesis focuses on the treatment of these cancers, with an emphasis on non-Hodgkin lymphomas (NHLs). R-CHOP (Rituximab-Cyclophosphamide, Doxorubicin hydrochloride, Oncovin/Vincristine, and Prednisone) is the standard of care first-line treatment for diffuse large B-cell lymphoma (DLBCL), the most common subtype of NHL, and encompasses a mixture of chemotherapy, immunotherapy, and corticosteroids. The R-CHOP regimen cures 50% to 70% patients, …