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Tolle Lege Works Published In 2020, Mcquade Library

Bibliographies

Compiled Tolle Lege bibliography of works published by members of the Merrimack College Community in 2020. Works include journal articles, books, book chapters, conference presentations and posters, and more.

Cardiorespiratory Fitness, Balance And Walking Improvements In An Adolescent With Cerebral Palsy (Gmfcs Ii) And Autism After Motor-Assisted Elliptical Training, Guilherme Manna Cesar, Thad W. Buster, Judith M. Burnfield

Department of Mechanical and Materials Engineering: Faculty Publications

Purpose: To quantify the impact of motor-assisted elliptical (ICARE) training on cardiorespiratory fitness, balance and walking function of an adolescent with walking limitations due to cerebral palsy.

Materials and methods: A thirteen-year-old boy with hemiplegic cerebral palsy (Gross Motor Function Classification System II) and autism participated. Peak oxygen consumption (peak VO₂, primary outcome measure), oxygen cost of walking, Pediatric Balance Scale (PBS), modified Timed Up and Go (mTUG), 2-Minute Walk Test (2MWT), and gait characteristics (speed, cadence, step length, single support time) were assessed prior to and after completion of 24 sessions of moderate- to vigorous- intensity ICARE …

Thei Student Applied Research Presentations Sarp 2020, Research Office, Technological And Higher Education Institute Of Hong Kong

THEi Student Applied Research Presentations (SARP)

No abstract provided.

Classical Engineering Systems Provide Behavioral Analog For Ephemeral Insect And Plant Biomechanics, Nicholas Smith

Electronic Theses and Dissertations, 2020-2023

In this dissertation we consider ephemeral behaviors of two small-scale living systems, mosquitoes and citrus fruit reservoirs. While these two systems share few obvious commonalities, they both express life events that are complex and conclude within approximately 50 milliseconds. We utilize high-speed videography, between 1,000-16,000 fps, to detail how complex behavior can be modeled as classical engineering systems. Beginning with the larger organism we assessed the landing and takeoff behavior of Aedes aegypti mosquitoes to ascertain the secrets of their covert interaction with humans. At takeoff, mosquitoes decrease pushing contact time with substrates of low friction through a modified takeoff …

Mobile Health Technology To Enhance Healthcare Service Delivery In Developing Nations (Saudi Arabia), Nawaf Khan

Electronic Theses and Dissertations, 2020-2023

Saudi Arabia is among the countries that have very high prevalence rates of diabetes and hypertension, with prevalence rates of almost 18% and 25%, respectively. The majority of patients with diabetes and hypertension fail to manage their diseases and to show up for their follow up appointments. Mhealth technology is among the interventions that have been recently adopted to overcome these issues and improve the quality of healthcare services. This study aims to evaluate the effectiveness of a mobile phone application named diabetes and hypertension application (DHA Tracking) to promote adherence for patients with diabetes and hypertension in Mecca, Saudi …

A Computational Biomechanical Model-Based Optimization Of Fulcrum Support In Orthosis Enabled Closed Reduction Of Developmental Dysplasia Of The Hip, Christopher Rose

Electronic Theses and Dissertations, 2020-2023

Hip abduction orthosis devices (HAOD) are used to reduce the hip joint of infants affected by developmental dysplasia of the hip (DDH). HAOD have been successful for mild cases of DDH and ineffective for severe cases. Efforts in understanding the biomechanics of lower limbs have been made to improve the success rate of current treatment methods, especially for Grade IV dislocations (G4). The aim of this dissertation is twofold: first, it proposes the use of a varying fulcrum point (FP) located below the leg to improve DDH treatment; and secondly, it defines the optimal FP (OP) location for a broad …

Assessment Of Dobhoff Tube Malposition On Radiographs Using Deep Learning, Kevin George, Paras Lakhani, Md

Phase 1

Introduction: Dobhoff tubes (DHT) are narrow-bore flexible devices that deliver enteral nutrition for critically ill patients. Tracheobronchial insertion of DHTs presents a significant risk for pulmonary complications. Thus, DHT insertion requires radiologist confirmation of correct placement with chest x-ray (CXR), increasing clinical delays. To address this, we demonstrate the novel application of Deep Convolutional Neural Networks (DCNNs) to automatically and accurately identify DHTs in CXRs in real time.

Methods: 141 de-identified HIPAA compliant frontal view chest radiographs containing DHTs in various positions were obtained. The DHTs were first manually segmented and verified by a board certified radiologist. Images were split …

Understanding The Effect Of Single- And Twin-Screw Extrusion Processing Parameters On Physical And Physico-Chemical Properties Of Sprouted Quinoa And Sprouted Proso Millets, Gabriela John Swamy

Electronic Theses and Dissertations

According to Mordor Intelligence Research, the new compositional research and moisture content extrusion process are helping the growth of the plant protein market. The demand for plant proteins is growing at a fast rate, owing to change in lifestyle, lack of balanced dietary intake, and improved research and development in order to develop new kinds of plant-protein enriched products. It is necessary to identify the right plant protein sources and choose the right processing methodology to create highly digestible foods which can be consumed by infants and elderly as well. In addition, it is important to support local farmers and …

Food Printing: Evolving Technologies, Challenges, Opportunities, And Best Adoption Strategies, Sharmin Attarin, Mohsen Attaran

Journal of International Technology and Information Management

3D printing is a process of making three-dimensional objects using additive processes where layers are laid down in succession to create a complete object. Companies across the globe are actively piloting and leveraging the inherent benefits of 3D printing technology. Today, 3D printing can revolutionize food innovation and production through better creativity, customizability, and sustainability. This article highlights 3D printing evolving technologies and trends and identifies its applications and implementation challenges. In this paper, we conducted a literature review to explore 3D printing's current technologies and applications in the food industry, including its advantages, its potential implications, and its obstacles …

Early Acid/Base And Electrolyte Changes In Permanent Middle Cerebral Artery Occlusion: Aged Male And Female Rats, Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Sarah J. Goodwin, David Powell, Doug Lukins, Justin F. Fraser, Keith R. Pennypacker

Neurosurgery Faculty Publications

BACKGROUND: Early changes in acid/base and electrolyte concentrations could provide insights into the development of neuropathology at the onset of stroke. We evaluated associations between acid/base and electrolyte concentrations, and outcomes in permanent middle cerebral artery occlusion (pMCAO) model.

METHODS: 18-month-old male and female Sprague-Dawley rats underwent pMCAO. Pre-, post- (7 min after occlusion), and at 72 hr of pMCAO venous blood samples provided pH, carbon dioxide, oxygen, glucose, hematocrit, hemoglobin, and electrolyte values of ionized calcium, potassium, and sodium. Multiple linear regression determined predictors of infarct and edema volumes from these values, Kaplan-Meier curve analyzed morality between males and …

The Journal Of Undergraduate Research: 2019

The Journal of Undergraduate Research

This is the complete issue of the South Dakota State University Journal of Undergraduate Research, Volume 17.

Development Of Cellulose Acetate-Based Scaffold For Bone Tissue Engineering Applications, Ruhit Sinha

Electronic Theses and Dissertations

Cellulose Acetate (CA) based biomaterials are being used as substrates for bone ingrowth applications due to their nontoxic and nonirritant nature coupled with optimum morphology and stiffness. Electrospinning with additives and/or post-treatment has emerged as a viable protocol to further improve mechanical properties of CA and expand its utility. Herein, we highlight the role of potassium chloride (KCl) in association with airdrying to enhance the elastic modulus and tensile strengths of CA fibers. Salt aggregation in between fibers is observed through Scanning Electron Microscopy (SEM), however, Fourier-transform infrared (FTIR) analysis signifies the interactions between K+ ions and acetyl groups. The …

Development Of 3d Porous Chitosan-Based Platform For In Vitro Culture, Kailei Xu

Electronic Theses and Dissertations, 2020-2023

Three-dimensional (3D) cell cultures have been widely used in biological research since two-dimensional (2D) cultures have many limitations including alteration of cell morphology, metabolic pathways and gene expression. Therefore, the application of 2D cell cultures in pharmaceutical companies for drug screening causes reproducibility issues in animal studies, which strongly influences the efficiency of drug development. The aim of my studies is to develop 3D cell culture models to better mimic the extracellular matrix (ECM) in tumor microenvironment, not only for deeper understanding of interaction between cells and ECM, but also for the application in drug screening. Three different compositions of …

Effects Of Electrical Stimulation And Methyl Jasmonate Elicitation On Camptothecin Production In Tissue Culture Of Ophiorrhiza Ridleyana, Supakit Pisitpaibool

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to enhance plant camptothecin (CPT) production in vitro, 5-month-old Ophiorrhiza ridleyana Craib. The plant cultures were treated with methyl jasmonate (MeJA) solution (0, 20, 50, and 100 µM) dissolved in ethanol, which was applied to the surface of the solid culture medium. The CPT content in the roots, stems, and leaves of the MeJA-elicited tissue-cultured plants at 12 and 24 h after the elicitation was determined by high-performance liquid chromatography (HPLC). It was demonstrated that the maximum CPT content in the tissue-cultured plants was achieved after 12 h elicitation with 50 µM MeJA. The average CPT contents …

Fabrication And Characterization Of Bacterial Cellulose-Chitosan/Alginate/Gelatin Hydrogel Scaffolds For Application In Cartilage Tissue Engineering, Phasuwit Phassorn Phatchayawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Biopolymers of bacterial cellulose (BC), chitosan (C), alginate (A) and gelatin (G) were combined to fabricate three-dimensional (3D) hydrogel composite scaffolds for tissue engineering applications. The bacterial cellulose-chitosan/alginate/gelatin (BCC-AG) hydrogel scaffolds were characterized for chemical property by Fourier transform infrared (FT-IR) spectroscopic analysis, morphology by scanning electron microscopy (SEM), mechanical properties, degradability, biocompatibility and potential application in cartilage tissue engineering. Results from Fourier transform infrared (FT-IR) spectroscopy showed some weak interactions among BC, chitosan, alginate and gelatin, but no chemical interaction between those biopolymers was observed. The morphology of BCC-AG hydrogel scaffolds under SEM observation revealed that alginate and gelatin …

Efficacy Of Hard Hats In Attenuating Head Accelerations: A Combined Experimental And Computational Investigation, Arthur Aloisio Alves Dos Santos

UNF Graduate Theses and Dissertations

Struck-by accidents are a leading cause of traumatic brain injuries in the construction industry. While hard hats are the conventional means of industrial head protection, the current test standard to evaluate hard hat performance does not assess their ability to mitigate head accelerations from such impacts. To address this gap in knowledge, three investigations were pursued as part of this thesis. First, a variety of commercially available hard-hat designs – differentiated by shell design, number of suspension points, and suspension tightening system – were tested for their ability to attenuate accelerations during vertical impacts to the head. All hard-hats appreciably …

อิเล็กโทรดีโพสิชันของโครงสร้างนาโนของทองแดงออกไซด์บนแผ่นรองรับทองแดงสำหรับการรีดักชันเชิงไฟฟ้าของไนตรัสออกไซด์, สิรภัทร นิลวิเชียร

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้ศึกษาการสังเคราะห์โครงสร้างนาโนของทองแดงออกไซด์บนแผ่นรองรับทองแดงโดยใช้วิธีอิเล็กโทรดีโพสิชันเพื่อให้ทองแดงมีพื้นที่ผิวสูงขึ้นเพื่อใช้เป็นตัวเร่งปฏิกิริยาโลหะทองแดงจากออกไซด์ในการทำปฏิกิริยารีดักชันเชิงไฟฟ้าของแก๊สไนตรัสออกไซด์ จากผลการศึกษาพบว่าปริมาณผลึกทองแดงออกไซด์แปรผันตามความหนาแน่นกระแสไฟฟ้าซึ่งหากมีค่าสูงเกินไปจะส่งผลให้เกิดการเกาะติดของผลึกไม่เต็มพื้นผิว นอกจากนี้ อุณหภูมิของอิเล็กโทรไลต์ที่สูงขึ้นทำให้ปริมาณผลึกเพิ่มขึ้นรวมถึงเกิดผลึกขนาดใหญ่ขึ้นอีกด้วย โดยพบว่าการอิเล็กโทรดีโพสิชันด้วยความหนาแน่นกระแสฟ้า -3.33 มิลลิแอมป์ต่อตารางเซนติเมตรและอุณหภูมิของอิเล็กโทรไลต์ 40 องศาเซลเซียสเป็นสภาวะที่ให้พื้นที่ผิวที่สูงที่สุด การอิเล็กโทรดีโพสิชันที่อุณหภูมิ 50 องศาเซลเซียสก่อให้เกิดผลึกขนาดใหญ่อย่างเห็นได้ชัดส่งผลให้พื้นที่ผิวในการทำปฏิกิริยาต่ำลง สำหรับการทำปฏิกิริยารีดักชันเชิงไฟฟ้าของแก๊สไนตรัสออกไซด์ด้วยตัวเร่งปฏิกิริยาโลหะทองแดงจากออกไซด์นั้น พบว่าความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดแก๊สไนโตรเจนแปรผันตามปริมาณตัวเร่งปฏิกิริยาซึ่งเป็นผลมาจากการควบคุมระยะเวลาในการอิเล็กโทรดีโพสิชัน โดยเวลาอิเล็กโทรดีโพสิชันที่เหมาะสมคือ 30 นาที โดยเกิดปฏิกิริยารีดักชันของแก๊สไนตรัสออกไซด์ที่ศักย์ไฟฟ้าเริ่มต้นประมาณ 0.2 V vs RHE และเกิดปฏิกิริยาการผลิตไฮโดรเจนที่ประมาณ -0.3 V vs RHE และเมื่อศักย์ไฟฟ้าสูงขึ้นทำให้ความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดแก๊สไนโตรเจนสูงขึ้นจนถึงศักย์ไฟฟ้าเท่ากับ -0.12 V vs RHE และลดต่ำลงที่ศักย์ไฟฟ้าที่สูงขึ้น ซึ่งให้ความหนาแน่นกระแสไฟฟ้าสำหรับการเกิดไนโตรเจนสูงสุดเท่ากับ -8.61 มิลลิแอมป์ต่อตารางเซนติเมตร และประสิทธิภาพเชิงฟาราเดย์ของการเกิดไนโตรเจนเท่ากับร้อยละ 98.5±1.7 นอกจากนี้ยังพบว่าตัวเร่งปฏิกิริยาทองแดงจากออกไซด์มีความเสถียรต่อการรีดักชันแก๊สไนตรัสออกไซด์เป็นเวลาอย่างน้อย 7 ชั่วโมง

Ecosystem Of Bagged Grain Stored Under Naturally Ventilated Warehouse: Analysis And Modelling, Michael Ayodele Omodara

Theses and Dissertations--Biosystems and Agricultural Engineering

Grain in Africa and indeed most developing parts of the world are stored in polypropylene or jute bags arranged in stacks of varied dimensions in naturally ventilated warehouses. This practice is, however, associated with high postharvest losses due to poor temperature and moisture management during storage. This constitutes a major economic and food security challenge in these countries. Therefore, this study characterizes changes in moisture content and temperature occurring in a stack of bagged corn by determining the permeability of bag materials that influence moisture transfer and developing a mathematical model of heat and mass transfer which incorporates the unique …

Lipemia Levels Analysis From Human Blood Samples, Zainab Ibrahim Alshoug

Dissertations, Master's Theses and Master's Reports

Worldwide, an estimated 31% of people who die each year have a cardiovascular disease (CVD), an all-encompassing group of diseases and conditions of the heart or blood vasculature. Access to portable, user-friendly tools to test lipid levels accurately and efficiently, without requiring large volume blood draws, will help improve access to wellness management by reducing costs and facilitating early screening and monitoring of CVD thus improving outcomes. Point of care micro or millifluidic chips to test biofluids that are integrated into detection units are an attractive measurement tool because of their potential for ease of use by patients at home …

Fourier Transform Infrared Spectroscopy (As A Rapid Method) Coupled With Machine Learning Approaches For Detection And Quantification Of Gluten Contaminations In Grain-Based Foods, Abuchi Godswill Okeke

Theses and Dissertations--Biosystems and Agricultural Engineering

Cross-contamination between food grains during harvesting, transportation, and/or food processing is still a major issue in the food industry. Due to cross-contact with gluten-rich grains (wheat, barley, and rye grains), gluten can get into food that’s naturally free from gluten and thus may not be safe for consumption for people susceptible to gluten-related disorders such as celiac disease, wheat allergy, gluten intolerance or sensitivity. The conventional method of gluten detection is cumbersome, time-consuming, and requires well-trained personnel. Therefore, there is a need for a rapid and equally effective technique to authenticate gluten contamination in foods. This research work explored the …

Journal Of The Arkansas Academy Of Science - Volume 74, 2020, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Energy Engineering Approach For Rural Areas Cattle Farmers In Bangladesh To Reduce Covid-19 Impact On Food Safety, Mohammad Nur-E-Alam, Mohammad Nasirul Hoque, Soyed Mohiuddin Ahmed, Mohammad Khairul Basher, Narottam Das

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This paper reports on the optimization of thin-film coating-assisted, self-sustainable, off-grid hybrid power generation systems for cattle farming in rural areas of Bangladesh. Bangladesh is a lower middle-income country with declining rates of poverty among its 160 million people due to persistent economic growth in conjunction with balanced agricultural improvements. Most of the rural households adopt a mixed farming system by cultivating crops and simultaneously rearing livestock. Among the animals raised, cattle are considered as the most valuable asset for the small-/medium-scale farmers in terms of their meat and milk production. …

Internet Of Things In Agricultural Innovation And Security, Abdul Salam

Faculty Publications

The agricultural Internet of Things (Ag-IoT) paradigm has tremendous potential in transparent integration of underground soil sensing, farm machinery, and sensor-guided irrigation systems with the complex social network of growers, agronomists, crop consultants, and advisors. The aim of the IoT in agricultural innovation and security chapter is to present agricultural IoT research and paradigm to promote sustainable production of safe, healthy, and profitable crop and animal agricultural products. This chapter covers the IoT platform to test optimized management strategies, engage farmer and industry groups, and investigate new and traditional technology drivers that will enhance resilience of the farmers to the …

Internet Of Things For Sustainable Human Health, Abdul Salam

Faculty Publications

The sustainable health IoT has the strong potential to bring tremendous improvements in human health and well-being through sensing, and monitoring of health impacts across the whole spectrum of climate change. The sustainable health IoT enables development of a systems approach in the area of human health and ecosystem. It allows integration of broader health sub-areas in a bigger archetype for improving sustainability in health in the realm of social, economic, and environmental sectors. This integration provides a powerful health IoT framework for sustainable health and community goals in the wake of changing climate. In this chapter, a detailed description …

Internet Of Things In Sustainable Energy Systems, Abdul Salam

Faculty Publications

Our planet has abundant renewable and conventional energy resources but technological capability and capacity gaps coupled with water-energy needs limit the benefits of these resources to citizens. Through IoT technology solutions and state-of-the-art IoT sensing and communications approaches, the sustainable energy-related research and innovation can bring a revolution in this area. Moreover, by the leveraging current infrastructure, including renewable energy technologies, microgrids, and power-to-gas (P2G) hydrogen systems, the Internet of Things in sustainable energy systems can address challenges in energy security to the community, with a minimal trade-off to environment and culture. In this chapter, the IoT in sustainable energy …

Electrospun Nanofiber Scaffolds As A Platform For Breast Cancer Research, Carolynn Que

Dissertations, Master's Theses and Master's Reports

Tumorigenesis is a complex process involving numerous cellular signaling cascades and environmental factors. Here, we report the fabrication of 3D scaffolds with different morphologies obtained by to study cancer cell proliferation and migration. Using an FDA approved, biocompatible and biodegradable polymer Polycaprolactone (PCL), we electrospun nanofiber scaffolds having mesh, aligned, and honeycomb morphologies. The role of the morphology and cellular preferences to nutrition in cell adhesion and proliferation was assessed using scaffolds obtained by electrospinning PCL with fluorescent fructose-like molecular probes. Cell viability, cell morphology, localized cellular growth as related to scaffold morphology and availability of the fructose-like molecular probes …

Brassinosteroids Inhibit Autotropic Root Straightening By Modifying Filamentous-Actin Organization And Dynamics, Louise De Bang, Ana Paez-Garcia, Ashley E. Cannon, Sabrina Chin, Jaydeep Kolape, Fuqi Liao, J. Alan Sparks, Qingzhen Jiang, Elison B. Blancaflor

Nebraska Center for Biotechnology: Faculty and Staff Publications

When positioned horizontally, roots grow down toward the direction of gravity. This phenomenon, called gravitropism, is influenced by most of the major plant hormones including brassinosteroids. Epi-brassinolide (eBL) was previously shown to enhance root gravitropism, a phenomenon similar to the response of roots exposed to the actin inhibitor, latrunculin B (LatB). This led us to hypothesize that eBL might enhance root gravitropism through its effects on filamentous-actin (F-actin). This hypothesis was tested by comparing gravitropic responses of maize (Zea mays) roots treated with eBL or LatB. LatB- and eBL-treated roots displayed similar enhanced downward growth compared with controls …

Functional Characterization Of Petiolule-Like Pulvinus (Plp) Gene In Abscission Zone Development In Medicago Truncatula And Its Application To Genetic Improvement Of Alfalfa, Juan Du, Shaoyun Lu, Maofeng Chai, Chuanen Zhou, Liang Sun, Yuhong Tang, Jin Nakashima, Jaydeep Kolape, Zhaozhu Wen, Marjan Behzadirad, Tianxiu Zhong, Juan Sun, Yunwei Zhang, Zeng-Yu Wang

Nebraska Center for Biotechnology: Faculty and Staff Publications

Alfalfa (Medicago sativa L.) is one of the most important forage crops throughout the world. Maximizing leaf retention during the haymaking process is critical for achieving superior hay quality and maintaining biomass yield. Leaf abscission process affects leaf retention. Previous studies have largely focused on the molecular mechanisms of floral organ, pedicel and seed abscission but scarcely touched on leaf and petiole abscission. This study focuses on leaf and petiole abscission in the model legume Medicago truncatula and its closely related commercial species alfalfa. By analysing the petiolule-like pulvinus (plp) mutant in M. truncatula at phenotypic level (breakstrength and …

การเตรียมเเละวิเคราะห์คุณลักษณะของอนุภาคลิโพโซมสำหรับกักเก็บสารอาร์บูตินด้วยเครื่องโฮโมจิไนเซอร์เเรงดันสูง, รัชพล ชูทับ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การกักเก็บสารสำคัญในรูปแบบของอนุภาคลิโพโซม เป็นวิธีการที่ได้รับความนิยมเป็นอย่างมาก เนื่องจากอนุภาคลิโพโซมมีส่วนประกอบที่สามารถเข้ากับร่างกายได้ ไม่มีความเป็นพิษ และสามารถย่อยสลายได้เอง รวมไปถึงช่วยเพิ่มเสถียรภาพของสารที่นำมากักเก็บให้ดีขึ้น วิธีการเตรียมอนุภาคลิโพโซมเพื่อกักเก็บสารเป็นหนึ่งปัจจัยที่จะต้องคำนึงถึง เพราะจะส่งผลต่อการกระจายตัวและขนาดของอนุภาค รวมไปถึงอัตราการปลดปล่อยของสารและเสถียรภาพความคงตัวของอนุภาคลิโพโซมด้วย งานวิจัยนี้มีความสนใจที่จะศึกษาการเตรียมอนุภาคลิโพโซมสำหรับกักเก็บสารอาร์บูตินด้วยเครื่องโฮโมจิไนเซอร์แรงดันสูง เนื่องจากอาร์บูตินเป็นสารที่มีเสถียรภาพต่ำการกักเก็บสารในรูปแบบของอนุภาคลิโพโซมมีความเป็นไปได้ที่จะช่วยเพิ่มเสถียรภาพให้กับสารอาร์บูติน การเตรียมอนุภาคด้วยเครื่องโฮโมจิไนเซอร์แรงดันสูงเป็นวิธีที่สะดวกและรวดเร็ว สามารถเตรียมอนุภาคลิโพโซมได้ในปริมาณที่มาก อีกทั้งยังมีความต่อเนื่องของกระบวนการโดยไม่ต้องผ่านหลายขั้น โดยวัตถุประสงค์ของงานวิจัยต้องการศึกษาปัจจัยต่างๆ ได้แก่ อัตราส่วนระหว่างฟอสโฟลิพิด คลอเรสเตอรอล และสารอาร์บูติน อัตราการปลดปล่อยของสารอาร์บูตินและเสถียรภาพความคงตัวของอนุภาคลิโพโซม รวมไปถึง สภาวะของเครื่องโฮโมจิไนเซอร์แรงดันสูง ได้แก่ ความดันและจำนวนรอบ ที่ใช้ในการเตรียมอนุภาคลิโพโซมเพื่อกักเก็บสารอาร์บูติน จากการศึกษาพบว่า การเตรียมอนุภาคลิโพโซมที่กักเก็บสารอาร์บูตินด้วยเครื่องโฮโมจิไนเซอร์แรงดันสูง ทำให้ได้ลิโพโซมขนาดเล็กที่มีผนังสองชั้นเพียงชั้นเดียว ซึ่งจะมีขนาดของอนุภาคลดลงอย่างมีนัยสำคัญเมื่อเพิ่มความดันและจำนวนรอบของเครื่องโฮโมจิไนเซอร์แรงดันสูง โดยมีขนาดเฉลี่ยอยู่ระหว่าง 150 ถึง 200 นาโนเมตร ผลการทดลองความเข้มข้นของลิพิดต่อความสามารถในการกักเก็บสารอาร์บูติน พบว่า เมื่อเพิ่มความเข้มข้นโดยรวมของลิพิด ประสิทธิภาพการกักเก็บสารมีค่าเพิ่มขึ้น ซึ่งมีค่าประสิทธิภาพการกักเก็บสารเฉลี่ยสูงสุดอยู่ที่ 74.29 เปอร์เซ็นต์ นอกจากนั้น ผลการทดลองยังแสดงให้เห็นว่าการกักเก็บสารสำคัญไว้ในรูปแบบของอนุภาคลิโพโซมและมีการเติมสารคลอเรสเตอรอลลงไปจะสามารถช่วยควบคุมอัตราการปลดปล่อยของสารสำคัญได้ รวมไปถึงช่วยเพิ่มเสถียรภาพความคงตัวให้กับอนุภาคลิโพโซมได้อีกด้วย ดังนั้น สภาวะของเครื่องโฮโมจิไนเซอร์แรงดันสูงและสัดส่วนระหว่างฟอสโฟลิพิดกับคลอเรสเตอรอลที่เหมาะสมในการเตรียมอนุภาคลิโพโซมสำหรับกักเก็บสารอาร์บูติน คือ ความดัน 1000 บาร์ จำนวน 3 รอบ ที่ความเข้มข้นโดยรวมของลิพิดร้อยละ 2 โดยน้ำหนัก อัตราส่วนระหว่างฟอสโฟลิพิดกับคลอเรสเตอรอล 10:2 โดยน้ำหนัก และสภาวะอุณหภูมิในการเก็บรักษาที่ 4 องศาเซลเซียส

Prediction Of The Optimal Catheter Placement Selection For Therapy Infusion To Treat Brain Tumors, Lisa Hope Antoine

All ETDs from UAB

ABSTRACT In 2020, the National Brain Tumor Society reported that physicians would diagnose more than 87,000 new cases of brain tumors. These cases will add to the approximately 700,000 individuals in the United States living with brain and central nervous system tumors. Almost 18,000 of these cases will prove fatal [1]. The blood-brain barrier (BBB) hinders the effective treatment of brain tumors. The task of this barrier is to protect the brain from composition instabilities in blood plasma and shield the brain from agents that may adversely impact brain functionality. However, by performing its tasks the barrier prevents potential effective …