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A Mathematical Framework For Estimating Risk Of Airborne Transmission Of Covid-19 With Application To Face Mask Use And Social Distancing, Rajat Mittal, Charles Meneveau, Wen Wu

Faculty and Student Publications

© 2020 Author(s). A mathematical model for estimating the risk of airborne transmission of a respiratory infection such as COVID-19 is presented. The model employs basic concepts from fluid dynamics and incorporates the known scope of factors involved in the airborne transmission of such diseases. Simplicity in the mathematical form of the model is by design so that it can serve not only as a common basis for scientific inquiry across disciplinary boundaries but it can also be understandable by a broad audience outside science and academia. The caveats and limitations of the model are discussed in detail. The model …

Santa Clara Magazine, Volume 61 Number 3, Fall 2020 [Print Issue V.61:2], Santa Clara University

Santa Clara Magazine

16 - THE GIFT Is sacrifice, given willingly and with love, what makes us human? Leslie Griffy.

20 - NOT A MOMENT, BUT A MOVEMENT From protests in Benson in 1969 to a multi-decade movement called Unity, students of color have consistently pushed SCU to progress. Matt Morgan.

28 - ON BEING BETTER Discover the ways we can better support each other, particularly as white people seek to become allies to people of color. Lauren Loftus.

32 - THE SACRIFICIAL TWEET Social media missteps are costly, perhaps now more than ever. Just what are we willing to give up to …

Global Convergence Of Covid-19 Basic Reproduction Number And Estimation From Early-Time Sir Dynamics, Gabriel G. Katul, Asaad Mrad, Sara Bonetti, Gabriele Manolia, Anthony J. Parolari

Civil and Environmental Engineering Faculty Research and Publications

The SIR (‘susceptible-infectious-recovered’) formulation is used to uncover the generic spread mechanisms observed by COVID-19 dynamics globally, especially in the early phases of infectious spread. During this early period, potential controls were not effectively put in place or enforced in many countries. Hence, the early phases of COVID-19 spread in countries where controls were weak offer a unique perspective on the ensemble-behavior of COVID-19 basic reproduction number inferred from SIR formulation. The work here shows that there is global convergence (i.e., across many nations) to an uncontrolled R_o=4.5 that describes the early time spread of COVID-19. This value …

The Glycocalyx And Its Role In Vascular Physiology And Vascular Related Diseases, Sheldon Weinbaum, Limary M. Cancel, Bingmei M. Fu, John M. Tarbell

Publications and Research

Purpose—In 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121–167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper.

Methods—A literature search mainly focusing on the role of the glycocalyx in the two major areas described above …

Effects Of Surface Topography On Bacterial Biofilm Formation, Sang Won Lee

Dissertations - ALL

Biofilms are multicellular structures with bacterial cells attached to a surface and embedded in an extracellular matrix. With high-level resistance to antimicrobial agents, biofilms are the cause of chronic infections associated with implanted medical devices such as breast implants, orthopedic devices, pace markers, and many others. Besides the prevalence, biofilm infections are associated with high mortality, presenting an urgent need for more effective controls. Several strategies such as coating with antimicrobial agents and changing chemical, physical, and biological properties of biomaterials have been attempted, but bacteria have remarkable capabilities to overcome unfavorable conditions over time and long-term biofilm control remains …

Dectin-1 Mediated Mechanical Force Generation In Candida Albicans Fungal Pathogen Recognition, Rohan Choraghe

Biomedical Engineering ETDs

Candida spp. pathogens continue to be a major health care burden with high mortality and exceeding a billion dollars in terms of healthcare cost. Candidainfection ranges from superficial dermatological infection to more serious blood stream infection in debilitated patients. One of the major lines of innate immune defense against Candidais phagocytosis. Dectin-1 is the antifungal receptor in myeloid cells responsible for most immune responses against fungi including phagocytosis. We looked into the signaling pathway coordinating this mechanical process downstream of Dectin-1. We found that Dectin-1 activation gives rise to a significant mechanical force generation mediated through RHOA-ROCK-MyosinII pathway. …

Analysis Of Risks Transmission And Control In Subway Construction, Qingjun Guo, Hongyu Yan, Bosen Li

Journal of System Simulation

Abstract: The process of the transmission and control of hidden dangers in subway construction is very similar to that of infectious diseases. Based on an engineering example, the characteristics of the complex system in the subway construction site are analyzed, and a simulation method using the propagation dynamics model to describe the interaction and propagation of various elements is proposed. Hazard source and hidden danger data of a section of Qingdao metro line 4 from march to August 2017 are selected as the original state, using by MATLAB R2014a simulation calculation, the densities of different elements are gotten, the process …

Ronald E. Mcnair Scholars Program Profiles And Abstracts 2020, Mcnair Scholars Program

McNair Symposium

This is the complete event program and provides presentation abstracts and biographies of McNair scholars and their mentors.

Large Face Shield, Michael Stieven, Dylan Huddleston, Timothy Bragg

Washington University / UMSL Mechanical Engineering Design Project JME 4110

The large face shield is designed to help stop the spread of COVID-19 Coronavirus in occupational environments where close contact is necessary.

The Investigation Of Surface Structures On Various Pathogens And Their Interactions With The Human Immune System, Carmen M. Villalobos

Biomedical Engineering ETDs

The cell surface is the first interface the host immune system encounters and

its investigation has led to a better understanding of cellular biology and types of

pathways that pathogens target in a host cell. The cell surface has evolved to include

many functions such as manipulation of the cytoskeleton, cell signaling, membrane

trafficking, adhesion, and integration into host tissue. The pathogens of interest are

the pathogenic fungus, Candida albicans, and the parasite, Giardia lamblia and we

investigate the consequences of drug treatments on the cell surface, leading to

promising new targets.

Resilience In Nonmetropolitan Nebraska: Capacity To Overcome Disasters And Hardships, 2020 Nebraska Rural Poll Results, Rebecca Vogt, Cheryl Burkhart-Kriesel, Brad Lubben, L.J. Mcelravy, Timothy Meyer, Steve Schulz, Jason L. Weigle

Rural Futures Institute: Publications

The definition of resilience is the capacity to recover quickly from difficulties. Synonyms include toughness, perseverance and grit. Last spring’s severe weather events and this year’s ongoing COVID-19 pandemic are likely testing the resilience of rural Nebraskans. Given that, how do rural Nebraskans rate their communities on dimensions that measure their resiliency? How confident are they that the federal government or local emergency management authorities can contain infectious disease outbreaks? How do they rate their ability to help their community handle adversities? How prepared are rural Nebraskans to deal with financial emergencies? This paper provides a detailed analysis of these …

Traffic Impacts Of The Covid-19 Pandemic: Statewide Analysis Of Social Separation And Activity Restriction, Scott Parr, Brian Wolshon, John Renne, Pamela Murray-Tuite, Karl Kim

Faculty Publications

The COVID-19 pandemic resulted in significant social and economic impacts throughout the world. In addition to the health consequences, the impacts on travel behavior have also been sudden and wide ranging. This study describes the drastic changes in human behavior using the analysis of highway volume data as a representation of personal activity and interaction. Same-day traffic volumes for 2019 and 2020 across Florida were analyzed to identify spatial and temporal changes in behavior resulting from the disease or fear of it and statewide directives to limit person-to-person interaction. Compared to similar days in 2019, overall statewide traffic volume dropped …

Cytomegalovirus Inhibition By Pluronic-Encapsulated Quercetin And Synergy With Ganciclovir, Ian Wadsworth

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Congenital cytomegalovirus (CMV) is the leading viral cause of birth defects worldwide and leads to a variety of complications. Ganciclovir is the most common anti-CMV drug used but often causes severe side effects. Quercetin, a plant pigment, shows anti-CMV activity that may provide a less toxic alternative to ganciclovir, or when co-administered, reduce ganciclovir treatments. However, a drug carrier is needed to deliver quercetin for CMV treatment. In this study, three Pluronic polymers (P123, F127, and F68) were investigated as a quercetin drug delivery system (DDS) for CMV treatment.

All selected Pluronics successfully encapsulated quercetin at varying degrees of efficacy. …

Alternate Warfare: The Unseen Weapons Of Mass Destruction, Elyse Keener

Liberty University Journal of Statesmanship & Public Policy

Biological warfare is a national security concern that transcends centuries. In the current international climate, biowarfare is of particular interest due to the COVID-19 pandemic. This article seeks to follow historical cases of biological warfare and international response to these cases in order to understand the implications of COVID-19, if it were to be weaponized. Also covered is the current capabilities that Russia, China, and Iran are assessed to possess.

Reprapable Automated Open Source Bag Valve Mask-Based Ventilator, Aliaksei Petsiuk, Nagendra Gautam Tanikella, Samantha C. Dertinger, Adam Pringle, Shane Oberloier, Joshua M. Pearce

Michigan Tech Publications, Part 1

This study describes the development of an automated bag valve mask (BVM) compression system, which, during acute shortages and supply chain disruptions can serve as a temporary emergency ventilator. The resuscitation system is based on the Arduino controller with a real-time operating system installed on a largely RepRap 3-D printable parametric component-based structure. The cost of the system is under $170, which makes it affordable for replication by makers around the world. The device provides a controlled breathing mode with tidal volumes from 100 to 800 milliliters, breathing rates from 5 to 40 breaths/minute, and inspiratory-to-expiratory ratio from 1:1 to …

A Systems-Level Approach To The Design, Evaluation, And Optimization Of Electrified Transportation Networks Using Agent-Based Modeling, Landon Clark Willey

Theses and Dissertations

Rising concerns related to the effects of traffic congestion have led to the search for alternative transportation solutions. Advances in battery technology have resulted in an increase of electric vehicles (EVs), which serve to reduce the impact of many of the negative consequences of congestion, including pollution and the cost of wasted fuel. Furthermore, the energy-efficiency and quiet operation of electric motors have made feasible concepts such as Urban Air Mobility (UAM), in which electric aircraft transport passengers in dense urban areas prone to severe traffic slowdowns. Electrified transportation may be the solution needed to combat urban gridlock, but many …

Simulation Analysis Of Beijing H1n1 Influenza Based On Spatial Clustering, Yitong Zhao, Mei Shan, Ma Liang, Zhang Wei

Journal of System Simulation

Abstract: Spatial cluster detection is widely used for disease surveillance, prevention and containment. In the early stages of illness, epidemics have similar symptoms to common diseases, making infectious disease data processing and analysis difficult. The Agent based modeling and simulation was used to generate H1N1 influenza data in Beijing. By designing a set of experiments, the epidemic monitoring results of two spatial clustering algorithms were analyzed. The results show that, using spatial clustering algorithms to analyze the simulation data of the epidemics can help to reveal the spread of the epidemic and play a positive role in the …

Energy Efficiency Evaluation Of Discrete Manufacturing System Based On Improved Entropy Method, Zhuqing Peng, Wang Yan, Zhicheng Ji

Journal of System Simulation

Abstract: For the characteristic of dynamic change randomness, variety, complexity and diversity in discrete manufacturing system, nine evaluation indexes were concluded from four aspects including product, equipment, economy and task flow, and energy efficiency evaluation index construction of discrete manufacturing system was structured. An improved entropy method was proposed. As the discrete degree of an index was too large when the entropy method was used to assign weight, the weight of the index would be very large. The idea of Analytic Hierarchy Model was used to improve the entropy method. So the improved entropy method could evaluate the discrete manufacturing …

Fabrication Of Hard–Soft Microfluidic Devices Using Hybrid 3d Printing, Carlos Ruiz, Karteek Kadimisetty, Kun Yin, Michael G. Mauk, Hui Zhao, Changchun Liu

Mechanical Engineering Faculty Research

Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed …

An Autoencoder And Artificial Neural Network-Based Method To Estimate Parity Status Of Wild Mosquitoes From Near-Infrared Spectra, Masabho Peter Milali, Samson S. Kiware, Nicodem J. Govella, Fredros Okumu, Naveen K. Bansal, Serdar Bozdag, Jacques D. Charlwood, Marta F. Maia, Sheila B. Ogoma, Floyd E. Dowell, George Corliss, Maggy T. Sikulu-Lord, Richard J. Povinelli

Electrical and Computer Engineering Faculty Research and Publications

After mating, female mosquitoes need animal blood to develop their eggs. In the process of acquiring blood, they may acquire pathogens, which may cause different diseases in humans such as malaria, zika, dengue, and chikungunya. Therefore, knowing the parity status of mosquitoes is useful in control and evaluation of infectious diseases transmitted by mosquitoes, where parous mosquitoes are assumed to be potentially infectious. Ovary dissections, which are currently used to determine the parity status of mosquitoes, are very tedious and limited to few experts. An alternative to ovary dissections is near-infrared spectroscopy (NIRS), which can estimate the age in days …

Mechanical Characterization Of Animal Derived Starting Materials For Tissue Engineering, Bin Zhang

Dissertations

Animal derived starting materials are well established in the production of Tissue Engineered Medical Devices. Porcine specifically can be found in products ranging in application from hernia repair to breast reconstruction. Although this material has been largely accepted in the Tissue Engineering industry, little is known of its material properties and mechanical characteristics. A review of the scientific literature describes limited mechanical measures only on uncontrolled research grade material. The objective of this work is to mechanically characterize porcine starting material used in the medical device industry. Porcine skin is provided by Midwest Research Swine, LLC (MRS) an established supplier …

Toxicant Disruption Of Immune Defenses Potential Implications For Fetal Membranes And Pregnancy, Sean M. Harris, Erica Boldenow, Steven E. Domino, Rita Loch-Caruso

University Faculty Publications and Creative Works

In addition to providing a physical compartment for gestation, the fetal membranes (FM) are an active immunological barrier that provides defense against pathogenic microorganisms that ascend the gravid reproductive tract. Pathogenic infection of the gestational tissues (FM and placenta) is a leading known cause of preterm birth (PTB). Some environmental toxicants decrease the capacity for organisms to mount an immune defense against pathogens. For example, the immunosuppressive effects of the widespread environmental contaminant trichloroethylene (TCE) are documented for lung infection with Streptococcus zooepidemicus. Group B Streptococcus (GBS; Streptococcus agalactiae) is a bacterial pathogen that is frequently found in the female …

Waiting-Time Paradox In 1922, Naoki Masuda, Takayuki Hiraoka

Northeast Journal of Complex Systems (NEJCS)

We present an English translation and discussion of an essay that a Japanese physicist, Torahiko Terada, wrote in 1922. In the essay, he described the waiting-time paradox, also called the bus paradox, which is a known mathematical phenomenon in queuing theory, stochastic processes, and modern temporal network analysis. He also observed and analyzed data on Tokyo City trams to verify the relevance of the waiting-time paradox to busy passengers in Tokyo at the time. This essay seems to be one of the earliest documentations of the waiting-time paradox in a sufficiently scientific manner.

Modeling Analysis And Prediction On Ncp Epidemic Transmission, Huaxiong Sheng, Wu Lin, Changliang Xiao

Journal of System Simulation

Abstract: The modeling analysis on the NCP (Novel Coronavirus Pneumonia) epidemic transmission before and after the closure of Wuhan is presented. On the basis of preprocessing the epidemic data, the classical SIR model and differential recurrence method are used to analyze and forecast the epidemic situation in the stage of control. The theoretical value and measured value fits well. In the stage of free transmission, the logistic model is used to compare and analyze the epidemic data five days in advance or later with the actual data to show the importance of taking the epidemic prevention measures in time. The …

Optimization Algorithm Based On Human Infection With Avian Influenza, Guangqiu Huang, Qiuqin Lu

Journal of System Simulation

Abstract: To get the global optimal solution of some complex nonlinear optimization problems, an optimization algorithm based on the human avian influenza infectious diseases is proposed by using its dynamic model of cross species transmission. Applies the H7N9 infectious disease model to create the operators S^u-S^u, I^u-I^u, S^u-I^u, I^u-S^u, S^u-D^u, I^u-D^u, and to enable the individuals to exchange information among the same species and cross-species. The S^u-S^u and I^u-I^u operators …

Stochastic Simulation Of Cellular Metabolism, Emalie J. Clement, Thomas T. Schulze, Ghada A. Soliman, Beata Joanna Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Increased technological methods have enabled the investigation of biology at nanoscale levels. Such systems require the use of computational methods to comprehend the complex interactions that occur. The dynamics of metabolic systems have been traditionally described utilizing differential equations without fully capturing the heterogeneity of biological systems. Stochastic modeling approaches have recently emerged with the capacity to incorporate the statistical properties of such systems. However, the processing of stochastic algorithms is a computationally intensive task with intrinsic limitations. Alternatively, the queueing theory approach, historically used in the evaluation of telecommunication networks, can significantly reduce the computational power required to generate …

Rapid Antibiotic Susceptibility Testing Platform For Direct Clinical Samples, Terrance Zhang

Honors Scholar Theses

Infectious diseases and septicemia are two of the major causes of death in the U.S., necessitating rapid treatment of septic patients with proper, efficacious antibiotics. Unfortunately, the emergence and spread of multidrug-resistant bacteria are continuously being aggravated by an abuse in antibiotic prescription at a clinical and agricultural level. It is known that antibiotic resistance evolves through the sequential accumulation of multiple mutations in bacteria, which is accentuated by prolonged exposure of bacteria to ineffective antibiotics when implementing traditional septicemia treatment. The goal of this project is to develop a novel, easy-to-use AST platform for rapid antimicrobial susceptibility profiling to …

Isolation And Selective Glycosylation Of Antisalmonellal Anthraquinones From The Stem Bark Of Morinda Lucida Benth. (Rubiaceae), Napoleon A. Mfonku, James A. Mbah, Norbert Kodjio, Donatien Gatsing, Jixun Zhan

Biological Engineering Faculty Publications

In this work we report the isolation, identification and antibacterial activity of two anthraquinones, 2-hydroxy-1-methoxyanthraquinone (1) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone (2), from the stem bark of Morinda lucida. These two natural products were selectively converted into two new glycosylated derivatives, 2-hydroxy-1-methoxyanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (3) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (4) by the filamentous fungus Beauveria bassiana ATCC 7159. Structure elucidation was accomplished based on the 1D and 2D NMR, IR and mass spectra. The glycosylated compounds 3 and 4 showed higher in vitro antibacterial activity against Salmonella enterica subsp. enterica sérovars Typhimurim (MIC of 8 μg/mL each) than the corresponding aglycons 1 and 2 (MIC of …

Socially Aware Network User Mobility Analysis And Novel Approaches On Aerial Mobile Wireless Network Deployment, Ismail Uluturk

USF Tampa Graduate Theses and Dissertations

Service demand patterns for wireless networks are evolving with the technological developments in areas such as personal computing, unmanned vehicles, and internet-of-things, where increasing mobile service demand is one of the significant challenges introduced. In addition to these new intrinsic dynamics, natural disasters and societal upheaval are also disrupting the conventional patterns of network demand. Situations like damaged infrastructure due to a natural disaster or large numbers of displaced people caused by political strife and social upheaval demand flexible, rapidly deployable network architectures. The increasing demands of next-generation communication services are straining the capabilities of the traditional approach of the …

Three-Dimensional Hydrodynamic Focusing For Integrated Optofluidic Detection Enhancement, Erik Scott Hamilton

Theses and Dissertations

The rise of superbugs, including antibiotic-resistant bacteria, and virus outbreaks, such as the recent coronavirus scare, illustrate the need for rapid detection of disease pathogens. Widespread availability of rapid disease identification would facilitate outbreak prevention and specific treatment. The ARROW biosensor microchip can directly detect single molecules through fluorescence-based optofluidic interrogation. The nature of the microfluidic channels found on optofluidic sensor platforms sets some of the ultimate sensitivity and accuracy limits and can result in false negative test results. Yet higher sensitivity and specificity is desired through hydrodynamic focusing. Novel 3D hydrodynamic focusing designs were developed and implemented on the …