Digital Commons Network^™

Regulation Of Osseous Healing By Macrophage-Derived Wnt Ligands, Jefferson Overlin Abaricia

Theses and Dissertations

Osseous healing is regulated by various classes of cells and signaling mechanisms. Of these, Wnt signaling has long been known to be critically important in directing the differentiation of mesenchymal stem cells (MSCs) into osteoblasts during bone healing. However, the source of these Wnt ligands is not known. Recently, a body of literature has arisen finding both beneficial and detrimental effects of macrophage-derived Wnt ligands on the regeneration of other tissues (liver, kidney, heart, and intestine), often by regulating inflammatory activation and stem cell behavior. As macrophages have been well-characterized as orchestrators of healing, their use of Wnt signaling to …

An Analysis Of Covid-19 Vaccine Allergic Reactions, Robert Schumaker, Michael Veronin, Trevor Rohm, Rohit Dixit, Shadi Aljawarneh, Juan Lara

Journal of International Technology and Information Management

From our study, all three covid-19 vaccines have a similar proportion of adverse reaction reports in which the patient had a history of allergies. However, the proportion of life-threatening outcomes were lower for those with the Janssen vaccine (0.62% hospitalization rate for Janssen versus 2.59% for Pfizer and 0.60% death for Janssen versus 5.15% for Moderna). In terms of specific allergies, patients with *cillin or sulfa allergies had the most adverse reactions to covid-19 vaccines, however, Janssen again had the lowest percentage of reported deaths (1.39% for *cillin-related allergy deaths for Janssen versus 6.10% for Pfizer). In terms of patient …

Investigating The Antitumor Effects Of A Dsrna-Nanoparticle Complex In An In Vitro Ovarian Cancer Model, Aaron Lewis

Theses and Dissertations (Comprehensive)

An estimated 1 in 70 women will be diagnosed with ovarian cancer in their lifetime. Despite advanced detection and treatment methods, it remains a silent killer with an expected survival rate of 50%. A developing method in cancer treatment is the use of compounds that stimulate the immune system to aid in the body's fight against the disease. This project focused on the use of the potent immune stimulant double-stranded RNA (dsRNA), commercially available as polyinosinic:polycytidylic acid, poly(I:C), to induce cytotoxicity in two ovarian cancer cell lines; SKOV-3 and OVCAR-3. Some challenges exist with the delivery of dsRNA due to …

Biocybersecurity: A Converging Threat As An Auxiliary To War, Lucas Potter, Orlando Ayala, Xavier-Lewis Palmer

Engineering Technology Faculty Publications

Biodefense is the discipline of ensuring biosecurity with respect to select groups of organisms and limiting their spread. This field has increasingly been challenged by novel threats from nature that have been weaponized such as SARS, Anthrax, and similar pathogens, but has emerged victorious through collaboration of national and world health groups. However, it may come under additional stress in the 21st century as the field intersects with the cyberworld-- a world where governments have already been struggling to keep up with cyber attacks from small to state-level actors as cyberthreats have been relied on to level the playing field …

A Fuzzy Expert System For Predicting The Mortality Of Covid'19, Monika Mangla, Nonita Sharma, Poonam Mittal

Turkish Journal of Electrical Engineering and Computer Sciences

The COVID-19 pandemic has had a widespread impact on health and economy across the globe. It is leading to a huge number of deaths per day. Few researchers have been attracted to analyzing the mortality rate of COVID-19 from various perspectives. During the research, it has become evident that these fatalities are not only caused by COVID19, but they are also affected by some other factors. The authors of this paper aim to encompass three important types of factors viz. risk factors, clinical factors, and miscellaneous factors that influence the mortality of COVID-19. This manuscript presents a rule-based model under …

New Normal: Cooperative Paradigm For Covid-19 Timely Detection Andcontainment Using Internet Of Things And Deep Learning, Farooque Hassan Kumbhar, Ali Hassan Syed, Soo Young Shin

Turkish Journal of Electrical Engineering and Computer Sciences

The spread of the novel coronavirus (COVID-19) has caused trillions of dollars of damages to the governments and health authorities by affecting the global economies. It is essential to identify, track and trace COVID-19 spread at its earliest detection. Timely action can not only reduce further spread but also help in providing an efficient medical response. Existing schemes rely on volunteer participation, and/or mobile traceability, which leads to delays in containing the spread. There is a need for an autonomous, connected, and centralized paradigm that can identify, trace and inform connected personals. We propose a novel connected Internet of Things …

Application Of Data And Geospatial Analysis In Energy And Health Systems, Ali Faghani

Graduate Research Theses & Dissertations

Having sustainable energy and health systems are the main factors in the vision plan of every country. Both of these systems are correlated with a variety of frameworks, including social, physical, technological, political, and economic factors. Therefore, different types of analytics methods can be implemented to develop the required assessments for those who make plans since understanding the effect of such factors individually, also their interactions, and the overall effect is crucial. With this regard, applications of data analysis and geospatial techniques in both energy, and health systems have recently gained attention. The proposed research here deployed advanced data analytics …

Development Of Novel Polymeric Materials For Their Application In Monitoring And Remediation Of Environmental Pollutants, Rishabh Shah

Theses and Dissertations--Chemical and Materials Engineering

Remediation of environmental pollutants from water is one of the major challenges in the 21st century. Utilizing novel polymeric materials to accomplish this challenge has garnered a lot of interest in recent times. Flexibility in synthesizing as well as functionalizing makes them attractive for their application in pollutant remediation. This work is based on development and characterization of novel crosslinked polymeric as well as linear polymeric materials from biphenyl-based monomers, biphenyl based crosslinker and a temperature responsive monomer (Nisopropylacrylamide (NIPAAm)) for their application in remediation of toxic pollutants such as polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs) and iron oxide nanoparticle …

A Model For Inhalation Of Infectious Aerosol Contaminants In An Aircraft Passenger Cabin, Bert A. Silich

International Journal of Aviation, Aeronautics, and Aerospace

Aerosol contamination of an aircraft cabin by infectious passengers is a concern of passengers, aircrew and the aviation industry. This may be especially important during a pandemic, such as COVID-19, where the full extent of aerosol transmission is not well understood. A statistical method to determine the number of infectious passengers on board along with a mathematical model estimating the contaminant concentration of aerosols in the cabin and the number of inhaled infectious particles by passengers is presented. An example is used to demonstrated how the results can be estimated during normal operations and emergency conditions with malfunctions of the …

Uvc Automatic Door Handle Sanitizer, Dean Dalton, Tate Patterson

Electrical and Computer Engineering

Infectious disease is easily spread through the use of door handles

• A virus placed on a single door handle can spread through the remainder of the building within 2 to 4 hours
• Ultraviolet Class C light (UVC) is effective at sanitizing surfaces easily and at a low cost
• UVC light can be harmful when there are high levels of direct exposure to the eyes

Automatic Door Handle Sanitizer

• The device applies UVC light to effectively sanitize while safely allowing the use of the door

A Development Of Disaster Risk Profile In Public Healthcare System During Flood Situation : A Case Study Of Nakhon Sawan City Municipality, Nakhon Sawan Province, Thailand, Kodchakorn Krutphong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research begins with the idea of the disaster risk assessment included in the disaster management’s well recognized international framework, the Sendai Framework for Disaster Risk Reduction. Then, the idea settles from the risk assessment concept combined with the emergency management knowledge that has the critical infrastructure topic, including the public healthcare system. The flood disaster is the kind of disaster that frequently occurs in Thailand and the study area, Nakhon Sawan City Municipality. Thus, this research aims to study disaster risk profiles in the public healthcare system in a specific local area. The outcome from this research is the …

Covid-19 Prediction Using Lstm Algorithm: Gcc Case Study, Kareem Kamal A. Ghany, Hossam Zawbaa, Heba M. Sabri

Articles

Coronavirus-19 (COVID-19) is the black swan of 2020. Still, the human response to restrain the virus is also creating massive ripples through different systems, such as health, economy, education, and tourism. This paper focuses on research and applying Artificial Intelligence (AI) algorithms to predict COVID-19 propagation using the available time-series data and study the effect of the quality of life, the number of tests performed, and the awareness of citizens on the virus in the Gulf Cooperation Council (GCC) countries at the Gulf area. So we focused on cases in the Kingdom of Saudi Arabia (KSA), United Arab of Emirates …

Bibliometric Review On Liver And Tumour Segmentation Using Deep Learning, Jayant Jagtap, Aamir Habeeb, Avinash Jha, Shrey Aggarwal, Khushi Gupta

Library Philosophy and Practice (e-journal)

One of the major organs in the body is liver where tumors occur often. Malignant liver tumors pose a serious hazard to human life and health. Manual segmentation of the liver organ and tumor from computed tomography (CT) scans is difficult, time-consuming, and skewed to the clinician's experience, yet it is essential for hepatic surgical planning. However, due to the following considerations, segmenting liver tumors from computed tomography (CT) images is difficult: In CT pictures, the contrast between the liver tumor and healthy tissues is low, and the boundary is indistinct; the picture of the liver tumor is confusing, with …

High-Speed Rail Safety Analysis Based On Dual-Weighted Complex Network, Liu Lv

Dissertations

This study uses a complex network model to analyze the causes of accidents in high-speed railway operations. By identifying the key factors that led to high-speed railway accidents, hidden safety hazards were discovered. This will help improve the operational safety of the U.S. high-speed rail line under construction.

The analysis uses the regional high-speed railway network in Guangzhou, China as a case study, including the railway (including high-speed railway) accidents that occurred in the company's jurisdiction from 2013 to 2017. With comparative analysis between general railways and high-speed railways, the changes of high-speed railway safety factors are explored. Data analysis …

Countering Internet Packet Classifiers To Improve User Online Privacy, Sina Fathi-Kazerooni

Dissertations

Internet traffic classification or packet classification is the act of classifying packets using the extracted statistical data from the transmitted packets on a computer network. Internet traffic classification is an essential tool for Internet service providers to manage network traffic, provide users with the intended quality of service (QoS), and perform surveillance. QoS measures prioritize a network's traffic type over other traffic based on preset criteria; for instance, it gives higher priority or bandwidth to video traffic over website browsing traffic. Internet packet classification methods are also used for automated intrusion detection. They analyze incoming traffic patterns and identify malicious …

Waterpipe: A Global Alarming Problem, Tarek Houri, Bilal Osta, Sara Mobayed, Rayan Farha, Mazher Issa

BAU Journal - Science and Technology

Waterpipe popularity has increased significantly in the recent decades to become the major cause of death worldwide. This practice, which is also known as hookah, shisha and Narghile that is based on tobacco burning, increases the percentage of tobacco smokers especially among young people, due to several factors such as the attracting effect of sweetened tobacco, the marketing role and the social acceptance of waterpipe. A literature review was constructed using "Pub med" as a searching tool to confirm by studies the differences in adverse effects between waterpipe and cigarette by analyzing the toxicant’s levels generated from them, evaluating the …

Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar

KGI Theses and Dissertations

The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …

Prediction Of Epidemic Transmission And Evaluation Of Prevention And Control Measures Based On Artificial Society, Bin Chen, Yang Mei, Chuan Ai, Ma Liang, Zhengqiu Zhu, Hailiang Chen, Mengna Zhu, Xu Wei

Journal of System Simulation

Abstract: The COVID-19 has been controlled under the strict measures,but how to normalize it deserves in-depth study.The COVID-19 transmission model and the human contact network are established separately based on SEIR model and the artificial social scenario.With the support of the multi-agent computational experiment method,a large sample calculation experiment was performed on the Tianhe supercomputer to simulate the epidemic transmission in typical areas such as communities,schools,and workplaces in artificial cities,and to predict and evaluate the risk of epidemic spread after resumption of work and school.The results show that epidemic prevention and control must be prepared for a …

Feasibility Of Continuous Fever Monitoring Using Wearable Devices, Benjamin L. Smarr, Kirstin Aschbacher, Sarah M. Fisher, Anoushka Chowdhary, Stephan Dilchert, Karena Puldon, Adam Rao, Frederick M. Hecht, Ashley E. Mason

Publications and Research

Elevated core temperature constitutes an important biomarker for COVID-19 infection; however, no standards currently exist to monitor fever using wearable peripheral temperature sensors. Evidence that sensors could be used to develop fever monitoring capabilities would enable large-scale health-monitoring research and provide high-temporal resolution data on fever responses across heterogeneous populations. We launched the TemPredict study in March of 2020 to capture continuous physiological data, including peripheral temperature, from a commercially available wearable device during the novel coronavirus pandemic. We coupled these data with symptom reports and COVID-19 diagnosis data. Here we report findings from the first 50 subjects who reported …

Bibliometric Survey On Effect Of Climate Factors On Spread Of Coronavirus (Covid-19), Seema Patil, Jay Makwana, Manish Attri

Library Philosophy and Practice (e-journal)

The new SARS-CoV-2 COVID-19 has spread quickly around the globe since it was first reported in Wuhan city of China, in December 2019 subsequent to being contracted from a zoonotic source. The main focus of this bibliometric survey is to recognize the few studies which have upheld the epidemiological hypothesis that the effect of climatic factors is playing a crucial role in the spreading of COVID-19. The analysis is done on the basis of 412 documents such as journals, articles, editorials, short surveys and some review papers. The United States contributes to the maximum number of publications followed by the …

Bibliometric Survey On Effects Of Climate Change On Incidences Of Infectious Diseases, Seema Harshad Patil, Yatharth Jain, Vedant Marathe

Library Philosophy and Practice (e-journal)

^{For understanding the influx of Infectious Diseases, research of climate change and its effects pertaining to the diseases is important. The motive of this bibliometric survey is to understand the research which has been carried out regarding the aforementioned topics. This paper summarizes the research in the 21st Century from 2001 to present. We conducted this analysis using tools such as Gephi, Researchgate, Scopus, ScienceScape, Google Scholar and Mapchart. This Bibliometric Survey on “Effects of Climate Change on Infectious Diseases” showed that maximum publications are articles. These publications are from conferences and journals related to Environmental Science. The United States …}

Understanding Of Aerosol Transmission Of Covid 19 In Indoor Environments, Adama Barro, Cathal O'Toole, Jacob S. Lopez, Matthew Quinones, Sherene Moore

Publications and Research

Our reason for discussing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) or 2019 novel corona virus (Covid-19), is to understand its aerosol transmission characteristics in indoor spaces and to mitigate further spread of this disease by designing a new HVAC system. The problem that we are tackling is the spread of covid-19 droplets through aerosol transmission by looking at potential engineering solutions to the existing HVAC systems. The purpose is to eradicate the spread of the COVID-19 by testing indoor spaces in an effort to understand the effectiveness of ventilation controls. We believe that scientists and engineers have not …

The Use Of Nanoparticles And Electrospun Fibers For Intravaginal Delivery To Treat Viral And Bacterial Infections And Electrophysiological Measurements Of Synthetic Chloride Channels., Farnaz Minooei

Electronic Theses and Dissertations

Female reproductive viral and bacterial infections affect millions of women worldwide. Given the diversity and magnitude of these unmet reproductive health challenges, topical administration of antiretrovirals (ARVs) and antibiotics have emerged as promising approaches to maintain and restore reproductive health. However, currently available intravaginal dosage forms often suffer from low user adherence and the need for frequent, daily administration to achieve therapeutic effect. To address these challenges, the broad goal of this research was to focus on the development of new localized nanoparticle (NP) and electrospun fiber dosage forms to prolong the delivery and enhance the efficacy of active agents …

Ac Electrokinetic Effect Of V-Electrode Pattern On Microfluids, Mohammad Salman Parvez

Theses and Dissertations

Electrokinetics has been used for guiding, pumping, and manipulating microfluidic particles for many years in the field of Biomedical, Microbiology, Chemistry, Medicine, and other fields of research, which makes it a ubiquitous tool for the multidisciplinary research on microfluidics. Between these two Alternating Current (AC) Electrokinetics have been proven to be more feasible for the researcher than the other one. In this research, we have investigated AC Electrokinetics and s effect on a new electrode configuration called V-electrode pattern. The V-electrode has been inspired and modified from the previous research work on the Orthogonal Electrode Pattern. In this research, this …

The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila

Graduate Theses and Dissertations

Virus filtration is an integral part of the downstream purification of mammalian cell culture-derived biotherapeutics to assure the viral safety of the products. Virus filtration membranes remove viruses based on a size-exclusion mechanism. Commercial parvovirus filers possess unique membrane structure and are designed to remove smaller non-enveloped parvoviruses with size 18-26 nm. However, some filters face issues, such as pre-mature fouling, the decline of filtrate flux, and reduction in virus retention. This doctoral dissertation focused on identifying the factors that influence the filtrate flux and the virus retention capability of commercial virus filters. The effects of solution pH and ionic …

Stem Education In College: An Analysis Of Stakeholders’ Recent Challenges And Potential Solutions, Santanu De, Georgina Arguello

FDLA Journal

A vast majority of academic disciplines and curricula in the college center around Science, Technology, Engineering, and Mathematics (STEM), which are critical to developing the skills necessary for a global workforce. Rapid changes in pedagogical setups, educational modes, and advances in instructional technology entail diverse challenges for key stakeholders (i.e. students, faculty, and the organizations). This paper highlights the most relevant challenges and potential solutions in STEM higher education at the college level, reported in the last decade. The holistic analysis combining the three stakeholders’ perspectives would help elucidate significant contemporary aspects impacting the fields. The goal is to further …

Be Students Engage With Industry Leaders At Virtual Conference, Usu College Of Engineering

College of Engineering News

Nov. 9, 2020 — The Biological Engineering Department hosted its third annual Intermountain Biological Conference on Oct. 30 and 31. This year’s theme was Biological Engineering’s Impact on Public Health. Featured speakers came from industry partners and government agencies. The event was held virtually due to COVID-19 restrictions. For the poster session, students were required to submit a video explaining their research along with a digital poster.

Effectiveness Of Building Systems Strategies For Mitigation Of Airborne Transmission Of Sars-Cov-2, Meng Kong, Jialei Shen, Bing Dong, Jianshun Jensen Zhang

Mechanical and Aerospace Engineering - All Scholarship

Airborne transmission has been recognized as a major transmission pathway for the infectious disease COVID-19. This study investigated the effectiveness of several indoor air quality (IAQ) control strategies on the mitigation of airborne transmission of SARS-CoV-2, the virus that causes COVID-19. The well-known airborne disease infection risk model (Wells-Riley equation) was used to estimate the infection risk of the SARS-CoV-2 in seven (7) different types of spaces including conference center/ballrooms, hotel bistro//cafeteria, hotel lobby, classrooms (lecture), conference room/small classroom, hotel or cruise ship guest rooms and open plan offices. The IAQ control strategies included increased ventilation rate, improved air distribution …

Covid 19 Impact On Aircraft Ground Time At Congonhas Airport (Cgh), Fabio Pereira Teixeira, Felipe Massao Higa, Ricardo Matsumoto Jakabi, Rodrigo Moreira Riberiro

Graduate Student Works

This project aims to research and analyze the impact of the increase of ground time at Congonhas Airport caused by the new safety procedures in aviation to avoid the spread of the COVID-19 virus.

Aviation is a highly regulated industry, with the high cost and tiny margins. It focuses on optimizing one of the most expensive assets, the aircraft. To keep aircraft flying is one of the airline's primary goals as aircraft on the ground means no revenue generation and cost increase.

Congonhas Airport is one of the busiest airports in Brazil and already operated on its limited capacity before …

Thermostabilization Of Viruses Via Complex Coacervation, Xue Mi, Whitney C. Blocher Mctigue, Pratik Umesh Joshi, Mallory K. Bunker, Caryn L. Heldt, Sarah L. Perry

Michigan Tech Publications, Part 1

Widespread vaccine coverage for viral diseases could save the lives of millions of people each year. For viral vaccines to be effective, they must be transported and stored in a narrow temperature range of 2–8 °C. If temperatures are not maintained, the vaccine may lose its potency and would no longer be effective in fighting disease; this is called the cold storage problem. Finding a way to thermally stabilize a virus and end the need to transport and store vaccines at refrigeration temperatures will increase access to life-saving vaccines. We explore the use of polymer-rich complex coacervates to stabilize viruses. …